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my enalapril arrived - a day earlier than i expected too, so i took it. *fingers crossed*
i also applied some more as a cream, lets see if it speeds up the process a bit
Can I ask what you done to apply it as a cream?
the tablets im using are enalapril 20mgs, so i broke it in half and took 10mgs orally. with the other half, i just put it into a small bowl with some water and mixed it in until it completely disappeared. then i just mixed it into the cream im using normally and applied it.
If you do a google search you will see that enalapril is not good as a soluable but captopril is. This is the reason they chose captopril in the cold cream case with regards to the keloid on that ladies hand, mainly because it is a good soluable.
im using something called enalapril maleate....is that just as good as normal enalapril?
Yea, it's the correct formula in caps.
There is my prospect of Lotrial(enalapril) lab Roemmers:
FArmulas
Lotrial 10 Comprimidos: Cada comprimido contiene Enalapril maleate 10 mg. Excipientes:
A c i d o silAcico coloidal; AlmidAn de maAz; Talco; Talco siliconado; Lactosa anhidra D . T. ;
C e l u l o s a m i c r o c r i s t a l i n a ; C o l o r a n t e a m a r i l l o o c a s o, l a c a a l u m A nica.
my enalapril arrived - a day earlier than i expected too, so i took it. *fingers crossed*
i also applied some more as a cream, lets see if it speeds up the process a bit
Can I ask what you done to apply it as a cream?
the tablets im using are enalapril 20mgs, so i broke it in half and took 10mgs orally. with the other half, i just put it into a small bowl with some water and mixed it in until it completely disappeared. then i just mixed it into the cream im using normally and applied it.
If you do a google search you will see that enalapril is not good as a soluable but captopril is. This is the reason they chose captopril in the cold cream case with regards to the keloid on that ladies hand, mainly bacuase it is good soluable.
all good, yeah i didnt think it made a good soluable. it mixed in, but still looked pretty granular - a bit like when you mix any tablet into a paste. all the scars im looking to treat it on are 4 month old hypertrophic scars, so it will be interesting to see what the results will be. i also have some indented scars, formed with the same thick grey scar tissue, so it will be interesting to see if they fill in, or go deeper.
im using something called enalapril maleate....is that just as good as normal enalapril?
I honestly think it you'd get a better result putting sand on your skin if it is not soluable enough. You need it to affect the angiotensin II mechanism, by it getting into the skin.
Also you need the enalapril to break up into Enalaprilat, and when enalapril is solid, it is definately not Enalaprilat which is liquid.
Captopril, which is soluable, got results by inhibiting the angiotensin II in the skin, I'd imagine if she had've continued beyond the six weeks, she'd have got a resolution with it, similar to the way an oral dose of enalapril completely eliminated a casarian scar.
BTW I'm getting sick of the name of this thread. The thread should be called scar free healing, not scarless healing.
http://flyproxy5.appspot.com/https/mrmc-ww....afirm.overview
The army says that regenerative medicine such as burns repair, scarless wound repair would hopefully be translated to clinical use by 4 years.
http://flyproxy5.appspot.com/https/mrmc-ww....afirm.overview
The army says that regenerative medicine such as burns repair, scarless wound repair would hopefully be translated to clinical use by 4 years.
From this video from that site it looks like this guys shoulder healed great using the stem cell spray gun. http://flyproxy5.appspot.com/http/channel....Videos/09347_00
http://flyproxy5.appspot.com/https/mrmc-ww....afirm.overview
The army says that regenerative medicine such as burns repair, scarless wound repair would hopefully be translated to clinical use by 4 years.
Warning for those who choose to click on the above link: there are some disturbing images on that page.
I'm into my 5th day of taking the enalapril. I've been taking the recommended 10mgs a day, but for a few days i doubled it, just to see what the effect would be.
so far theres been nothing major. my mum commented my hypertrophic scars on my face look a bit less red. ive noticed some appear to be reducing in height - but ever so slightly. on my arms, where i have 3 big hypertrophic scars, ive noticed when i stretch my arm out, a big crease forms in the middle of two of them - which didnt happen to that extent previously.
ive had no change in my actual acne scars. one thing ive noticed is the scars on the face seem to respond more readilly than those on the body - redness wise at least.
im terms of side effects, there hasnt been any at all too. i feel slightly light headed when standing up and sitting, but overall its a lot less than when i used to use niacin.
overall, im looking for a complete improvement and no less, otherwise i have no hesitation in jumping off a bridge, but we wont discuss that. ive been emailing some of the docs who preformed the original studies (both topical and oral) to gain some additional information and have also emailled dr Lam,
so far, the only response ive recieved is from one of people in charge of the oral enalapril study and he maintains the scar "almost" completely disappeared. as for his response to whether it turned into a mature hypertrophic scar (flat, shiny and grey) or like normal skin, he didnt answer that part of the question. overall tho, im not sure how much to believe. especially since the doc i used to email about iodine was absolutely certain it would completely regenerate scars too, and we now know it didnt.
anyhoo, will keep you all updated
im keen to hear how everyone else on the enalapril is going
In this study they were looking at keloids, the keloids nearly disappeared over many months.
However in the context of looking at the keloids, they noticed a hypertrophic scar did completely disappear.
IMO it sounds like the Dr is talking about the keloid.
the lady in charge of the topical captopril responded. she said she moved cities, which is why the second stage trial never began. she did describe the results as only "quite reasonable" with "no significant complications", except for some irritation where the cream was applied. she says since it isnt approved, no one should give it a go tho.
i wish theyd just answer my specific questions tho, rather than giving such generalised statements.
The treatment was only done for 6weeks
http://flyproxy5.appspot.com/https/mrmc-ww....afirm.overview
The army says that regenerative medicine such as burns repair, scarless wound repair would hopefully be translated to clinical use by 4 years.
IMO we should all quit using the term scarless healing, and call it scar free healing.
http://flyproxy5.appspot.com/https/mrmc-ww....afirm.overview
The army says that regenerative medicine such as burns repair, scarless wound repair would hopefully be translated to clinical use by 4 years.
IMO we should all quit using the term scarless healing, and call it scar free healing.
Seabs you can send a reply to some admin, for change the name of this thread to 'scar free healing' like you say, and delete the 'juvista' word in the name of the thread to because, whe talk on this thread of all news hopes and not only of juvista.
http://flyproxy5.appspot.com/https/mrmc-ww....afirm.overview
The army says that regenerative medicine such as burns repair, scarless wound repair would hopefully be translated to clinical use by 4 years.
IMO we should all quit using the term scarless healing, and call it scar free healing.
Seabs you can send a reply to some admin, for change the name of this thread to 'scar free healing' like you say, and delete the 'juvista' word in the name of the thread to because, whe talk on this thread of all news hopes and not only of juvista.
I'd think this would be down to Tom_Mason.
Sorry I haven't posted an update in a while I just haven't had anything to say really. Coconut scar sorry for not replying to your PMs I hope this post will answer your questions.
I'm on day 46 or 47 of enalapril and have been taking 20mg a day. So far I haven't seen any improvement in any of my scars. I'm primarily hoping for improvement in my stretch marks but I do have mild acne scarring and also a very small hypertrophic scar, so I'm the perfect guinea pig really. I honestly haven't seen any improvement in any of my scars, but I'm keeping an open mind as this is a long term treatment. What worries me is that after 46/47 days I would have thought that I would have seen at least some small improvement, I haven't. My hypertrophic scar is very small so by now I expected it to be pretty much gone, there's no improvement.
In the research paper it says the keloid scar "dramatically improved" after 15 days. I've been on enalapril over 3 times as long as this and so far nothing.
It's disheartening really but there's not much I can do. I'll keep going with the enalapril as I have nothing to lose really and it's easy enough to swallow a pill or two everyday. At some point I'm going to do a strong TCA peel over one of my stretch marks to see if that helps things along. If enalapril doesn't work on stretch marks, then maybe you could turn a stretch mark into a hypertrophic/keloid scar by using a strong peel and effectively burning yourself.
do you think taking 1800 mgs of enalapril in one sitting would kill u?
The report stated that a low dose 10mg was the dosage that nearly removed the keloid in 3 to 4month and removed the caesarian in 3 to 4 month.
You cannot be for real. You must be taking the piss IMO. I have not read of any dosage recommendation of 1800mg.
IMO if you or anyone has taken that or are thinking of taking that without informing yourself you are either a fool or you are taking the piss.
aww that sucks so much hope when into this just like this epic thread.
What that means: ???
Professor Mark Ferguson, CEO Renovo, said: "We are extremely surprised and disappointed by the failure of Juvista to meet the Phase III trial primary and secondary endpoints. The Board of Renovo will now consider all options open to it to maximise shareholder value."
The REVISE Trial
This was a double blind, within patient, placebo controlled trial to assess the efficacy of two dose levels of Juvista (200ng and 500ng/100ul/linear cm of wound margin) given twice, following wound closure and 24 hours later, on the appearance of scars following scar revision surgery. Over 350 patients were recruited from 56 centres in UK France, Hungary, Germany, Italy, Poland, Spain, Denmark, Latvia and USA. The EMA agreed primary endpoint for efficacy was a photographic based assessment at 12 months following surgery by an independent panel of experts using the Global Scar Comparison Scale. Secondary endpoints included an assessment of the scars using the Global Scar Comparison Scale by the patients themselves and by the clinical trial investigator. None of the primary or secondary endpoints were met for either dose.
Juvista fails or what?