Acne.org Products
a real one looks like its for sale on ioffer.com called anapril
its 5mgs and it looks like its being shipped from asia, so no clue how customs would take it.
they accept paypal which is a plus.
no clue if we can post links here, but here goes
http://www.ioffer.com/i/enalapri-malea-ana...-ship-166887287
An interview with Prof. Fiona Woods about the future of trauma medicine.
She thinks that everything is going well for a scarless future:
http://riausondemand.org.au/blogs/scarless-healing/
She compares future medicine with a car wash centre. 
)
NEO
My only fear, assuming you were able to obtain the drug, is that all drugs carry risks and to some extent even complications of some kind..however, some people may not be phased.
I have read a lot about systematic enzymes supposedly dissolving fibrin over time but was unable to find scientific data to support, what looked like more marketing hype..
Of particular interest were Serrapetase and Nattokinease....they thin the blood...
i'm trying to think of a safer alternative to medications but at this time this is all i can come up with. i wonder if we broke capsules of the enzymes and applied them to scars to try to dissolve the fibrous tissue...just a thought.
At any rate, seabs has mentioned all throughout this thread the importance of decorin and enalaprin, insulin, etc..collectively, we should push these
issues to the mainstream, as evidence supports this; everything else seems pointless because it isn't completely scar free..
I also want to thank many of you for your contributions ..Lapis Lazuli has talked to many people etc.. and posted many informative things.
we'll win the battle if we stay focused on the mission.
maybe seabs can answer this better but...isn't decorin increased by the hepatocyte growth factor?
isn't this the result of mensenchymal stem cells?
Decorin. When you are non wounded your fibroblasts are dormant and arrested. They can't proliferate and create scar. Your tissues regenerate. Your tissues are flooded with decorin.
When your tissues are injured, the decorin levels are non existant, the fibroblasts proliferate. You then get scar.
What does decorin do? Decorin is a scar inhibitor. At 200nm decorin inhibits fibroblast proliferation. At the same time your non wounded tissues go on without necrosis and mass apoptosis. It stops scar.
why do i have the feeling of ~
a lack of trust about this?
i guess, i would prefer if it came from a doctor
which would be a battle to obtain for this specific purpose
i don't feel comfortable taking something that i purchase overseas fromthe internet.
How do i know what i'm getting? what else is added? (flow agents etc..) we just don't know
is it worth jeopardizing the rest of our health
i'm forced to ask the doctors even as i know the answer already. 
My only fear, assuming you were able to obtain the drug, is that all drugs carry risks and to some extent even complications of some kind..however, some people may not be phased.
I have read a lot about systematic enzymes supposedly dissolving fibrin over time but was unable to find scientific data to support, what looked like more marketing hype..
Of particular interest were Serrapetase and Nattokinease....they thin the blood...
i'm trying to think of a safer alternative to medications but at this time this is all i can come up with. i wonder if we broke capsules of the enzymes and applied them to scars to try to dissolve the fibrous tissue...just a thought.
At any rate, seabs has mentioned all throughout this thread the importance of decorin and enalaprin, insulin, etc..collectively, we should push these
I also want to thank many of you for your contributions ..Lapis Lazuli has talked to many people etc.. and posted many informative things.
we'll win the battle if we stay focused on the mission
maybe seabs can answer this better but...isn't decorin increased by the hepatocyte growth factor?
isn't this the result of mensenchymal stem cells?
Decorin. When you are non wounded your fibroblasts are dormant and arrested. They can't proliferate and create scar. Your tissues regenerate. Your tissues are flooded with decorin.
When your tissues are injured, the decorin levels are non existant, the fibroblasts proliferate. You then get scar.
What does decorin do? Decorin is a scar inhibitor. At 200nm decorin inhibits fibroblast proliferation. At the same time your non wounded tissues go on without necrosis and mass apoptosis. It stops scar.
im unsure whether to go and try this enalapril. i have quite large hypertrophic scars that are now flat, but still redden throughout hte day. whilst im sure it will help, i have a feeling it will just fade them to a grey colour and not actually remove the tissue - so it will always look like a scar.
im curious when in the study they say, the scar completely resolved - do they mean it became flat and grey, but still shiny, or that the scar actually completely disappeared? *ah this bothers me*
i emailled one of the people who wrote the study and asked the above question and they maintain the enalapril regenerated the scar to the point that there was almost no scar. im not sure what the "almost" means, but its interesting. i just wish they werent so subjective.
This is the quote from the case
Moreover, the old hypertrophic scar (due to cesarean sections) completely disappeared after 3-4 months of enalapril treatment.
It says it completely removed a scar.
Also if you look at the captopril study you can actually see the scar shrinking after 6weeks of treatment...
New Renovo website will be up soon:
http://www.renovo.com/itemdetails.asp?c_id=31&news_id=76
Maybe the new one will also have new info.
New Renovo website will be up soon:
http://www.renovo.com/itemdetails.asp?c_id=31&news_id=76
Maybe the new one will also have new info.
cross the fingers, we hope some good news all 
good news: good pics about trial 3 
http://www.neocutis.com/article.php?sid=18
On the other hand, TGF-AY1 and AY2 neutralizing antibodies do not entirely prevent scarring in the adult, and recent studies question the efficacy of TGF-AY3 in wound healing [15, 16]. This suggests that factors other than TGF-AY may also be important in scarless repair. For instance, extracellular matrix constituents fibromodulin or decorin, which are expressed as a function of gestation age in fetal skin, are known to modulate TGF-AY activity. This supports the hypothesis that differential expression of TGF-AY isoforms and TGF-AY activity modulators, rather than the mere presence or absence of TGF-AY has a role in the regulation of scarless repair.
Other growth factors differently expressed during the transition from scarless to scar-forming repair include epidermal (EGF) and platelet derived growth factor (PDGF) [17], as well as fibroblast growth factors (FGFs) [18]. High EGF levels were found in early-gestational age skin, which may help to rapidly reepithelialize after skin injury. In addition, rapid healing of fetal wounds may be also related to a higher level of vascular endothelial growth factor (VEGF) in scarless fetal wounds than in scarring fetal and adult wounds [19]. This high VEGF level may increase angiogenesis and vascular permeability early during healing.
Although known for its profibrotic role in wound healing inducing scar formation [20, 21], PDGF mRNA levels
were higher in scarless wound healing. This suggests that its function may be isoform dependent and may relate in a more complex manner to the extracellular environment.
FGFs have a broad range of function. For example, FGF-2 (basic FGF) is a potent stimulator of angiogenesis, while FGF-5 regulates the hair cycle. FGF-7 (also known as keratinocyte growth factor 1, KGF-1) and FGF-10 (KGF-2) are produced by fibroblasts but act on keratinocytes to stimulate migration and proliferation. FGF isoforms are regulated in a complex manner during fetal skin development. Whereas some FGF isoforms did not change, FGF-7 and FGF-10 were found to be down-regulated in scarless wounds.
It seems that when seems to have a solution, appear more problems...
http://www.neocutis.com/article.php?sid=18
On the other hand, TGF-AY1 and AY2 neutralizing antibodies do not entirely prevent scarring in the adult, and recent studies question the efficacy of TGF-AY3 in wound healing [15, 16]. This suggests that factors other than TGF-AY may also be important in scarless repair. For instance, extracellular matrix constituents fibromodulin or decorin, which are expressed as a function of gestation age in fetal skin, are known to modulate TGF-AY activity. This supports the hypothesis that differential expression of TGF-AY isoforms and TGF-AY activity modulators, rather than the mere presence or absence of TGF-AY has a role in the regulation of scarless repair.
Other growth factors differently expressed during the transition from scarless to scar-forming repair include epidermal (EGF) and platelet derived growth factor (PDGF) [17], as well as fibroblast growth factors (FGFs) [18]. High EGF levels were found in early-gestational age skin, which may help to rapidly reepithelialize after skin injury. In addition, rapid healing of fetal wounds may be also related to a higher level of vascular endothelial growth factor (VEGF) in scarless fetal wounds than in scarring fetal and adult wounds [19]. This high VEGF level may increase angiogenesis and vascular permeability early during healing.
Although known for its profibrotic role in wound healing inducing scar formation [20, 21], PDGF mRNA levels
were higher in scarless wound healing. This suggests that its function may be isoform dependent and may relate in a more complex manner to the extracellular environment.
FGFs have a broad range of function. For example, FGF-2 (basic FGF) is a potent stimulator of angiogenesis, while FGF-5 regulates the hair cycle. FGF-7 (also known as keratinocyte growth factor 1, KGF-1) and FGF-10 (KGF-2) are produced by fibroblasts but act on keratinocytes to stimulate migration and proliferation. FGF isoforms are regulated in a complex manner during fetal skin development. Whereas some FGF isoforms did not change, FGF-7 and FGF-10 were found to be down-regulated in scarless wounds.
It seems that when seems to have a solution, appear more problems...
and again no mention of the importance of decorin levels in scar free healing...how can they not know ?
I checked out ioffer but enalapril is no longer available. anyway here's some more of the same regarding scarless healing :
Cytokines and growth factors are key elements in scarless wound healing
TECHNOLOGY / Paradigm of Scarless Wound Healing
Recently, many experimental and clinical studies demonstrated that wound healing is regulated by a panoply of cytokines, growth factors and their receptors [11]. They influence cell migration, growth and proliferation in a complex, orchestrated manner and are involved in neutrophil and macrophage infiltration, angiogenesis, fibroplasia, matrix deposition, scarring and reepithelialization. Besides platelets and macrophages, fibroblasts are the major cellular source of cytokines or growth factors during wound healing.
Recent data strongly suggests that scarless wound healing in fetal skin at early gestation is a result of the unique cytokine or growth factor profile. Of these, transforming growth factor-beta (TGF-AY) has been most widely studied as it is implicated in the transition between scarless healing and repair with scar formation [2].
Called growth factors for historical reasons, their main function is to control cell proliferation and differentiation and to stimulate the synthesis of extracellular matrix such as collagen.
Three highly homologue TGF-AY isoforms are known in humans: AY1, AY2 and AY3. Each form has been found by immunohistochemistry in unwounded fetal skin. However, low levels of TGF-AY1 and high levels of TGF-AY3 are expressed at gestational ages associated with scarless repair. In addition, it appears that the relative proportion of TGF-AY isoforms, and not the absolute concentration of any one isoform determines the wound repair outcome.
Exogenous application of TGF-AY1 to normally scarless fetal wounds resulted in scar formation [12, 13]. Moreover, an adult-like inflammatory response was observed. The profibrotic nature of TGF-AY1, and possibly TGF-AY2, was confirmed in wounds of adult rats as neutralizing TGF-AY1 and AY2 with antibodies partially reduced the amount of scarring. TGF-AY1 stimulates collagen I production, which is the predominant collagen type in adult skin. On the other hand, supplementation with TGF-AY3 reduced scarring and inflammation in adult wounds confirming its potential antifibrotic properties. The fact that scarless fetal wounds heal with little inflammation and the onset of scarring during fetal repair correlates with the presence of an acute inflammatory infiltrate [14] may be related to the pronounced anti-inflammatory properties of TGF-AY3.
On the other hand, TGF-AY1 and AY2 neutralizing antibodies do not entirely prevent scarring in the adult, and recent studies question the efficacy of TGF-AY3 in wound healing [15, 16]. This suggests that factors other than TGF-AY may also be important in scarless repair. For instance, extracellular matrix constituents fibromodulin or decorin, which are expressed as a function of gestation age in fetal skin, are known to modulate TGF-AY activity. This supports the hypothesis that differential expression of TGF-AY isoforms and TGF-AY activity modulators, rather than the mere presence or absence of TGF-AY has a role in the regulation of scarless repair.
Other growth factors differently expressed during the transition from scarless to scar-forming repair include epidermal (EGF) and platelet derived growth factor (PDGF) [17], as well as fibroblast growth factors (FGFs) [18]. High EGF levels were found in early-gestational age skin, which may help to rapidly reepithelialize after skin injury. In addition, rapid healing of fetal wounds may be also related to a higher level of vascular endothelial growth factor (VEGF) in scarless fetal wounds than in scarring fetal and adult wounds [19]. This high VEGF level may increase angiogenesis and vascular permeability early during healing.
Although known for its profibrotic role in wound healing inducing scar formation [20, 21], PDGF mRNA levels
were higher in scarless wound healing. This suggests that its function may be isoform dependent and may relate in a more complex manner to the extracellular environment.
FGFs have a broad range of function. For example, FGF-2 (basic FGF) is a potent stimulator of angiogenesis, while FGF-5 regulates the hair cycle. FGF-7 (also known as keratinocyte growth factor 1, KGF-1) and FGF-10 (KGF-2) are produced by fibroblasts but act on keratinocytes to stimulate migration and proliferation. FGF isoforms are regulated in a complex manner during fetal skin development. Whereas some FGF isoforms did not change, FGF-7 and FGF-10 were found to be down-regulated in scarless wounds.
Summarizing, unique properties of fetal skin appear to contribute to perfect wound healing: (i) differential expression of TGF-AY isoforms together with other cytokines decreases scar formation and enhances reepithelialization, (ii) fetal fibroblasts with high synthetic capabilities deposit collagen rapidly and scarlessly, and (iii) lack of pro-inflammatory signals may limit the inflammatory infiltrate early during healing.
Despite the great increase in knowledge gained over the past decade, the precise mechanisms of scarless healing remain unknown. Additional cytokines, growth factors or modulators, which may further participate in the complex orchestration of coordinated cellular responses leading to perfect skin repair, are currently being researched.
well, with that news i'm thinking this may not work because perhaps the enalaprine is not genuine?
this is frustrating. they're doing great things as far as growing organs ..i have the feeling the technology is here but the fda is either too concerned that this indeed is the cure and thus other forms of treatment will be eradicated..and they wont be able to generate the kind of money that is made through lasers and medications. as the fda states, we can't use the word cure.
i have these very tiny but very thin lines that are inbedded in the skin of the forehead..they are close together making it look bigger in lighting than it obviously is.. (because of the shadow) creating a slight depression this is minor damage..the result of c02 laser. and it pisses me off as the rest of my skin is fine..lasers are risky...if i can get genuine denatured ecm i would attempt to use it on these..
i wonder if i did medical needling (from a professional) to puncture those small marks and applied the dust/ mesh afterwards?
Thanks bud.
was feeling a little more frustrated than usual today ..
i truly believe we have scar free treatments already.
this needs to get to the mainstream like mega fast =
what do we have to do?
Petition? Get all the scar sufferers to sign something online? I dunno..thinking out loud but it couldn't hurt.
genuine denatured ecm ..we want it now!
Coconut scar
Each person is different , a few can work and not others, you must prove itself and then make a trial, never disappoint.
And i want to say that should make a treatment for 5 or 6 months to see if it really works that surely the process is slow.
in the case of mr president , i believe that can work that the only 4 months had that problem, and even this fresh the healing process. Then he has more potential to cure.
In cases of OLD scars i believe we must combine a peeling medium with TCA to help eliminate fibrosys and promote the excellent cure that ''in theory'' has the skin under the effect of enalapril, so I will try in that way.
Remember it's a process slow... there are 5 or 6 months treatment, and if you have an 'old' scar, maybe you must mix whit TCA peel to help.
i wish good luck to bout, and remember...
A person may not work and to other yes, any person and any organism is different (blood ,skin,etc) , so DO NOT surrender, and i if i have positive developments would comment.
thank you friends.
i agree with what you're saying
i must admit i have become impatient but there are things we can all do
i will never do laser as i mentioned before..if it wasn't for laser i wouldn't be here searching..that's when the real problems started.
i'm interested in genuine denatured ecm
and enalapril but yes perhaps some form of peel could be helpful while taking enalapril
I think a cold shower would do some good too
