Acne.org Products
Cited facts:
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
4 TIMES A DAY?
If shot four times a day for months, you destroy the skin puncture.
It said on the 1976 report that the patient injected the 3x3cm scar 4 times a day over 82 days.
Cited facts:
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
4 TIMES A DAY?
It said on the 1976 report that the patient injected the 3x3cm scar 4 times a day over 82 days.
And which is the scientific explanation? The insulin reduces the tgf-b1 or what? Or as is its method of action to eliminate scars? I haven't seen a reasonable explanation even on the method of action of insulin.
Cited facts:
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
4 TIMES A DAY?
It said on the 1976 report that the patient injected the 3x3cm scar 4 times a day over 82 days.
And which is the scientific explanation? The insulin reduces the tgf-b1 or what? Or as is its method of action to eliminate scars? I haven't seen a reasonable explanation even on the method of action of insulin.
The important thing here in this 1976 report is not the microscopic detail (e.g. Is it practical to hire a geologist to look at the brick under the microscope before you build a house?), it clearly shows and explains a result, the result is scar free healng which was achieved by injecting the four quadrants of the 3x3 scar with infulin every day for 82 days.
BTW if you research the 2009 Linge study, in her work she describes some mechansm, she mentions a few IGF.
Cited facts:
Scar free healing is here.
Scarring is created by fibroblast proliferation.
Decorin at 200nm has been shown to keep the fibroblasts completely dormant, therefor scar free healing.
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
In 2006 enalapril, which works by inhibiting fibroblast proliferation, by using angiotensin II suppression, completely regenerated a 25year old hypertrophic scar. A cream called captopril another angiotensin II suppression agent, reduced a keloid by 9mm, from 11mm to 2mm in a six week period.
And there is more and more, ECM, we've seen earlier ecm appligraf produce scar free healing, we've seen alloderm etc.
Anyone who comes on to this board and talks as if scar free healing is not here to is talking shit...
I've been lurking around here for a couple of years actually.
I also have free university access to all medical and/or scientific journals... So if you could point me in the right direction (links preferably) to peer reviewed clinical studies on humans that prove scar free healing has been done, and not just medical hypothesis, I,'d be more than happy to read them. 
Cited facts:
Scar free healing is here.
Scarring is created by fibroblast proliferation.
Decorin at 200nm has been shown to keep the fibroblasts completely dormant, therefor scar free healing.
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
In 2006 enalapril, which works by inhibiting fibroblast proliferation, by using angiotensin II suppression, completely regenerated a 25year old hypertrophic scar. A cream called captopril another angiotensin II suppression agent, reduced a keloid by 9mm, from 11mm to 2mm in a six week period.
And there is more and more, ECM, we've seen earlier ecm appligraf produce scar free healing, we've seen alloderm etc.
Anyone who comes on to this board and talks as if scar free healing is not here to is talking shit...
I've lurking around here for a couple of years actually.
I also have free university access to all medical and/or scientific journals... So if you could point me in the right direction (links preferably) to peer reviewed clinical studies that prove scar free healing has been done, and not just medical hypothesis, I,'d be more than happy to read them.
I've been studying scar free healing on this board for 5 years, my account has been here since 2007. But to anyone who critically thinks time looking at something does not change facts. I couldn‚„t care if you have been lurking, just like anyone shouldn‚„t care if I‚„ve been here since 2007. Anyway in my time here looking at facts, two things have become obvious. Scar free healing has been done, (we've even seen evidence of it) and people come onto this board plugging products which don‚„t promote scar free healing, they then try to reinforce it with others, by praising the link and ignoring the facts. Pretending to be ignorant, or just ignorant?
Scarring is created by fibroblast proliferation. Fibroplasia. The proliferation of fibroblasts. Now that is a fact. Fibroblast proliferation creates excess collagen, which is scar. That is a fact.
However what is clear is fibroblasts create scar. And in non wounded tissues, were these fibroblasts are dormant, they are arrested, we don‚„t get scar. At this time your decorin levels flood the tissue.
Upon injury, two things happen, the decorin levels become almost non existant and the fibroblast proliferate, the decorin levels don‚„t reach a normal rate until 12 month later, longer in keloid cases. In that time the body fills the injury with a scar. Can you see a link between the lack of decorin and scar?
I have brought up cites on this board in the past, and what I say is consistent.
More on decorin, at 200nm decorin completely arrests the fibroblast proliferation. At the same time your tissues do not suffer necrosis, but continue to thrive. Scar free healing.
Scar free healing is here with decorin. Merely because the fact is a scar cannot develop with adequate levels of decorin, because decorin cuts off the supply of fibroblasts. (A metaphor for you: if I turned of your water supply, how are you going to get the water from your house to have a drink)
In an attempt to be the gatekeeper of information, in guiding information on the board, you mention peer reviewed studies and thus hide behind a point to mummy and daddy authority (appealing to authority, look the fallacy up). Saying 'Look what I say has authority, what he says doesn't, see in my version of events I‚„m backed up by mummy.'
Yet what I say is cited fact, this is not my opinion, this is me messaging facts.‚„ And if I wanted to play the authority game I could point to authority and go nana nana na. But I‚„ll let everyone decide for themselves.
Also putting a smug smiley, you try to make it seem like my information is just hypothesis. As if this is the only thing, the information I have provided to this discussion has 'evidence.' You ignore that so you can pick an argument and look good in an argument. But what I say has evidence resulting from a hypothesis, a hypothesis by itself has no evidence. What I say has evidence.
Using authority, no doubt you will tell us you are an anonymous Dr Authority and we should only look at your misinformation? Also which I find insulting and annoying you give the illusion that I ignore or do not know about peer reviewed studies. You try to sound smug as if I do not know what I'm talking about, perhaps trying to get my information debased? and you completely ignore my consistency.
Anyway, regarding your convenient appeal to authority, In 1976, a study proved scar free healing with evidence (this study has been backed up in 2009, 33year on, in 2009 scarring was reduced after one injection). This 1976 study did not (as far as I know) go through a peer reviewed study, but it showed and explained evidence that any self thinker would see (with a hypothesis it showed evidence ffs. This was not just a hypothesis by itself). Now do you discount that because some lightbulb changers decided to not to look at this patient, talk to the patient and the Dr, and look at this case in 1976 that showed scar free healing? Does this make this study shit because some gatekeepers decided to not look at it, or didn‚„t have the resources to look at it? Do you rely on authority to stamp approval?
If you critically think like you are trying to pretend you do, you would note that: peer reviewed studies, though they give better information than you get from future plugged products, have biases too, they also have limited resources, they are no were near perfect in they can shun information as I think has happened in the 1976 case which did not get investigated until the 2000's.
Also with peer reviews, they rely on a subjective measurement between peers, they are not useful if something has an objective fact or with something in a case study. Thus they will probably not waste a ton of resources on a study if the point proven is 100% as there is not much room for subjectivity, anyone can see black is black. With the 1976 study, anyone can see for themselves that the result was 100% scar free healing and was a case, it was an objective fact. Why do you need 11 people or what ever the number it is to see an objective fact?
Anyway you want a reviewed case that has been seen with part of the resources of a peer review?
OK playing with your authority, with you wanting a peer reviewed study I will give you a case were there was a bit of subjective measurement with 13 patients who received a CEA spray. The case in point would be a treatment of CEA suspension on burns victims brought scar free healing or near scar free healing. Btw evidence was actually presented on this board about 2 years ago. The evidence on the board highlighted scar free healing.
In this CEA suspension study the Vancouver Scar Scale though it is subjective, but peer reviewed, brought results based from the subjective measurement, perfect for a peer review which btw is almost pointless with objective facts. if I remember correctly the result were averaging 1.8 with a range from 0 tp 8. (BTW in the Vancouver Scar Scale 0 = scar free healing, and the Vancouver range range is, I think 0 to 13). This shows scar free healing resulted from the spray as judged by peer review.
So you want a study that hasn‚„t been ignored by peer reviews, like the 1976 study was? A study that can have a subjective measurement? which the 1976 study cant. Then here is a peer reviewed study that was not ignored, this one also proved scar free healing.
Look up Sprayed cultured epithelial autografts for deep dermal burns of the face and neck.
But we should always go by what our eyes tell us and use information as reference. In this thread we have seen examples of scar free healing it has been proven by factual information.
Tough post to follow but I must ask.
The best photos I've seen to help correct acne scarring is: subcision + fraxel Re:pair + ReCell(possibly negligble)
Then there's no photos but these are suppose to be the cutting edge:
Cutasil:
http://sirnaomics.com/products2.html
ACell:
http://www.acell.com/av_video.php
Juvista coming next year:
http://www.renovo.com/content.asp?c_id=9
And finally you are saying this works 100%:
200nm decorin
If money wasn't an issue, what would be the best course of action within the next 30 to 60 days as I am going to do the first procedure up top with ReCell for hell of it.
I don't want to spend 10 Grand if I don't have to but I'm tired of waiting years after Accutane.
So my question is what is the procedure/products and who do I talk to.
Thanks in advance.
Enalapril needs of hydrochlorothiazide (a diuretic) to operate in scars?
Case ReportCase 1
S.I. (the first author of this study), at the age of 54, underwent left colectomy for adenocarcinoma of the colon in 2002 and developed a postsurgical abdominal red keloid scar that was erythematous and painful.After 4 months, a consulted surgeon confirmed the diagnosis of keloid because the lesion expanded in a claw-like fashion beyond the borders of the scar. He decided against surgical revision because of the risk for keloid diathesis and the high risk of recurrence associated with surgery. The patient had a preexisting hypertrophic surgical scar that was the result of 2 long-ago cesarean sections (performed 30 and 25 years before), and this scar was sometimes itchy and eczematous. In the meantime, the patient was treated for mild arterial hypertension with low-dose enalapril (10 mg, once a day) ,coupled with a very low dose of hydrochlorothiazide (3 mg, once a day), administered in the morning. After 15 days of this treatment, the keloid scar dramatically improved, with a nearly complete recovery. Spontaneous resolution was ruled out as the reason for this rapid improvement, and this drew attention to the effect of the drug. Moreover, the old hypertrophic scar (due to cesarean sections) completely disappeared after 3a4 months of enalapril treatment.
Case 2
R.Z., a 70-year-old female with well-controlled diabetes who had undergone surgical removal of a tumor on her colon 2 years previously, developed a postsurgical abdominal keloid scar which, upon observation, was very prominent. The scar was red, had irregular borders, and showed increased vascularization. It is noteworthy that the patient also had a red, rounded keloid scar at the site where a drainage tube had been inserted at the time of surgery. These keloids, therefore, should be considered as long-standing lesions. The patient was intentionally treated with the same drugs as the patient in Case 1 (10 mg enalapril and 3 mg hydrochlorothiazide, once a day), administered in the morning. The keloid scars slowly improved, showing a very good response after 6 months.The 2 patients still continue enalapril treatment, which is effective in controlling their arterial blood pressure.
Tough post to follow but I must ask.
The best photos I've seen to help correct acne scarring is: subcision + fraxel Re:pair + ReCell(possibly negligble)
Then there's no photos but these are suppose to be the cutting edge:
Cutasil:
http://sirnaomics.com/products2.html
ACell:
http://www.acell.com/av_video.php
Juvista coming next year:
http://www.renovo.com/content.asp?c_id=9
And finally you are saying this works 100%:
200nm decorin
If money wasn't an issue, what would be the best course of action within the next 30 to 60 days as I am going to do the first procedure up top with ReCell for hell of it.
I don't want to spend 10 Grand if I don't have to but I'm tired of waiting years after Accutane.
So my question is what is the procedure/products and who do I talk to.
Thanks in advance.
Honestly, if you'd have asked me a few weeks ago I'd have gave my advice. But it wont matter what I say. As you will be swamped with information/misinformation on here. The only thing I can say to you is research and inform yourself.
Tough post to follow but I must ask.
The best photos I've seen to help correct acne scarring is: subcision + fraxel Re:pair + ReCell(possibly negligble)
Then there's no photos but these are suppose to be the cutting edge:
Cutasil:
http://sirnaomics.com/products2.html
ACell:
http://www.acell.com/av_video.php
Juvista coming next year:
http://www.renovo.com/content.asp?c_id=9
And finally you are saying this works 100%:
200nm decorin
If money wasn't an issue, what would be the best course of action within the next 30 to 60 days as I am going to do the first procedure up top with ReCell for hell of it.
I don't want to spend 10 Grand if I don't have to but I'm tired of waiting years after Accutane.
So my question is what is the procedure/products and who do I talk to.
Thanks in advance.
Honestly, if you'd have asked me a few weeks ago I'd have gave my advice. But it wont matter what I say. As you will be swamped with information/misinformation on here. The only thing I can say to you is research and inform yourself.
Honestly, I wasn't asking for a scientific elaboration and explicitation of methods. I was just asking for a one sentence answer.
So if you can't answer that in one sentence; what are you doing about your acne scars sir?
Tough post to follow but I must ask.
The best photos I've seen to help correct acne scarring is: subcision + fraxel Re:pair + ReCell(possibly negligble)
Then there's no photos but these are suppose to be the cutting edge:
Cutasil:
http://sirnaomics.com/products2.html
ACell:
http://www.acell.com/av_video.php
Juvista coming next year:
http://www.renovo.com/content.asp?c_id=9
And finally you are saying this works 100%:
200nm decorin
If money wasn't an issue, what would be the best course of action within the next 30 to 60 days as I am going to do the first procedure up top with ReCell for hell of it.
I don't want to spend 10 Grand if I don't have to but I'm tired of waiting years after Accutane.
So my question is what is the procedure/products and who do I talk to.
Thanks in advance.
Honestly, if you'd have asked me a few weeks ago I'd have gave my advice. But it wont matter what I say. As you will be swamped with information/misinformation on here. The only thing I can say to you is research and inform yourself.
Honestly, I wasn't asking for a scientific elaboration and explicitation of methods. I was just asking for a one sentence answer.
So if you can't answer that in one sentence; what are you doing about your acne scars sir?
BTW I'm not being rude, you seem to be able to or keen to inform yourself and as such I think I'm pointing something out. The fact that there is IMO an aggressive approach to pass on information, the information propagated can sometimes be misinformation. This applies to anything. This will skew anyones view if they take the word of one person as authority on a subject. Informing yourself is much better than taking advice whole heartedly from anyone that is what I was trying to get across.
All II was saying is you really need to research this for yourself first and foremost.
However there are many approaches I would do after researching. Again research for yourself.
So my question is what is the procedure/products and who do I talk to.
Seabs do yo see that: Enalapril needs of hydrochlorothiazide (a diuretic) to operate in scars?
in bout experiment, enalapril mix whit hydrochlorohiazide, maybe we need bout things togheter to work. maybe the hydrochlorohiazide can do the enalapril work well.
the hydrochlorohiazide it's a diuretic.
So my question is what is the procedure/products and who do I talk to.
Seabs do yo see that: Enalapril needs of hydrochlorothiazide (a diuretic) to operate in scars?
in bout experiment, enalapril mix whit hydrochlorohiazide, maybe we need bout things togheter to work. maybe the hydrochlorohiazide can do the enalapril work well.
the hydrochlorohiazide it's a diuretic.
I believe the hydrochlorothiazide was used purely because it's what the first women was already using. In the research paper the first women was already taking enalapril and hydrochlorothiazide for hight blood pressure issues. They noted her scars healed so tried it on a second women and they decided to use the exact same medication, both enalapril and hydrochlorothiazide. I don't think hydrochlorothiazide is necessary at all. I remeber thinking the exact same thing about the hydrochlorothiazide and I tried to do a little bit of research to see how necessary it was.
Both medicines are used to treat high blood pressure. Sometimes people take them in combination as it helps to lower blood pressure through two different mechanisms:
The ACE inhibitor works by causing blood vessels to relax, lowering pressure and increasing the supply of blood and oxygen to the heart.
The diuretic (hydrochlorothiazide) works on the kidneys to increase the flow of urine, reduce the amount of water in the body and reduce blood pressure.
So to summarise, I don't think hydrochlorothiazide is needed at all, but that is just the conclusion I came to from my limited research, I may be wrong.
Seabs do yo see that: Enalapril needs of hydrochlorothiazide (a diuretic) to operate in scars?
in bout experiment, enalapril mix whit hydrochlorohiazide, maybe we need bout things togheter to work. maybe the hydrochlorohiazide can do the enalapril work well.
the hydrochlorohiazide it's a diuretic.
Yeah it is interesting. However IMO if something did not work here, trouble shooting, I wouldn't initially think it was the hydrochlorohiazide. I'd think something along the lines of the pills used have not suppressed angiotensin II in the local area of the scar for some reason. I'd first look at the ace inhibitor first.
An ace inhibitor by itself as well as removing scar from skin, has stopped and inhibited and regenerated scar tissue in rabbits, etc.
16th Day of Enalapril - No changes to scarring yet. Far too early to say really. Don't really know what to expect from it or how much time it will take to see improvement.
In one of the research papers it says "After 15 days of this treatment, the keloid scar dramatically improved". So I thought there might be the slight chance at seeing some small improvement but nothing as yet. I believe the hypertrophic scars took longer to respond.
16th Day of Enalapril - No changes to scarring yet. Far too early to say really. Don't really know what to expect from it or how much time it will take to see improvement.
In one of the research papers it says "After 15 days of this treatment, the keloid scar dramatically improved". So I thought there might be the slight chance at seeing some small improvement but nothing as yet. I believe the hypertrophic scars took longer to respond.
Your facts are wrong with regards to the hypertrophic scar. In the paper the hypertrophic scar completely cleared up, there was no trace of any ceasarian scar.
it said the caesarian hypertrophic scar cleared up in 3 to 4month, (there was no trace of the scar) and after this time the keloid was still resolving, but improving.
BTW I've just ordered captopril, I'm planning on making a solution. I'm just worried that I might not have been given captopril. I fear the website I bought it off may be dodgy. I think I made a mistake.
Looking at it after purchase it seemed fishy and tacky and the whois told me the domain had just been bought two weeks earlier.
Apparently though captopril has a taste when diluted.
16th Day of Enalapril - No changes to scarring yet. Far too early to say really. Don't really know what to expect from it or how much time it will take to see improvement.
In one of the research papers it says "After 15 days of this treatment, the keloid scar dramatically improved". So I thought there might be the slight chance at seeing some small improvement but nothing as yet. I believe the hypertrophic scars took longer to respond.
Your facts are wrong with regards to the hypertrophic scar. In the paper the hypertrophic scar completely cleared up, there was no trace of any ceasarian scar.
it said the caesarian hypertrophic scar cleared up in 3 to 4month, (there was no trace of the scar) and after this time the keloid was still resolving, but improving.
BTW I've just ordered captopril, I'm planning on making a solution. I'm just worried that I might not have been given captopril. I fear the website I bought it off may be dodgy. I think I made a mistake.
Looking at it after purchase it seemed fishy and tacky and the whois told me the domain had just been bought two weeks earlier.
Apparently though captopril has a taste when diluted.
I strongly suggest not using any drug from such a source. You think you have problems now...just wait. If you really want to have something to worry about that becomes 10 times more concerning than your scars than go ahead and use it.
16th Day of Enalapril - No changes to scarring yet. Far too early to say really. Don't really know what to expect from it or how much time it will take to see improvement.
In one of the research papers it says "After 15 days of this treatment, the keloid scar dramatically improved". So I thought there might be the slight chance at seeing some small improvement but nothing as yet. I believe the hypertrophic scars took longer to respond.
Your facts are wrong with regards to the hypertrophic scar. In the paper the hypertrophic scar completely cleared up, there was no trace of any ceasarian scar.
it said the caesarian hypertrophic scar cleared up in 3 to 4month, (there was no trace of the scar) and after this time the keloid was still resolving, but improving.
BTW I've just ordered captopril, I'm planning on making a solution. I'm just worried that I might not have been given captopril. I fear the website I bought it off may be dodgy. I think I made a mistake.
Looking at it after purchase it seemed fishy and tacky and the whois told me the domain had just been bought two weeks earlier.
Apparently though captopril has a taste when diluted.
I strongly suggest not using any drug from such a source. You think you have problems now...just wait. If you really want to have something to worry about that becomes 10 times more concerning than your scars than go ahead and use it.
I'll have a look at it when it arrives but I'm probably not going to use this purchase. The purchase was a mistake. The web page I looked at looked similar to a website I had visited before, that has been around a long time and has a customer contact number.
However when I inspected the website I used, the page was an attempt at a clone. Also when I moved away from the page the site became tacky and looked nothing like the different domain site I had visited earlier.
I will be looking into buying the captopril still though and I'll be using it as a solution to put locally on my scarring.
any suggestions on where to find enalapril?
Thank you
hello coconut and everyone else. i've been looking up how to buy captopril - which is supposed to be similar (at least i think it is) for the last few days and have been looking up all the various places online.
the only one that looked remotely trustworthy is called Pharmacy Escrow and they claim to be operating in London. The only downside is they dont accept Mastercard and when I asked for their banking details, I got an address in Port Louis, Mauritius. To make matter worse, the if you do more of a search, you will find them running out of the Bahamas. Doing even more searching finds the address is home to a number of scams. Then again, they meet all the Verify requirements and all that, so maybe the are trustworthy.
The alternative is that I'm thinking of printing off the variuous studies and taking them to my psychologist who might be able to prescribe it due to its mood uplifting effects. If that doesnt work, I could try my local GP - although i highly doubt theyd be willing to help.....grr..
My only fear, assuming you were able to obtain the drug, is that all drugs carry risks and to some extent even complications of some kind..however, some people may not be phased.
I have read a lot about systematic enzymes supposedly dissolving fibrin over time but was unable to find scientific data to support, what looked like more marketing hype..
Of particular interest were Serrapetase and Nattokinease....they thin the blood...
i'm trying to think of a safer alternative to medications but at this time this is all i can come up with. i wonder if we broke capsules of the enzymes and applied them to scars to try to dissolve the fibrous tissue...just a thought.
At any rate, seabs has mentioned all throughout this thread the importance of decorin and enalaprin, insulin, etc..collectively, we should push these 
issues to the mainstream, as evidence supports this; everything else seems pointless because it isn't completely scar free..
I also want to thank many of you for your contributions ..Lapis Lazuli has talked to many people etc.. and posted many informative things.
we'll win the battle if we stay focused on the mission.
maybe seabs can answer this better but...isn't decorin increased by the hepatocyte growth factor?
isn't this the result of mensenchymal stem cells?