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By the way, i read in a report, TGF-B3 DOWNREGULATES THE TGF-B1, so i think that's way juvista only have 'TGF-B3', and not mix whit reducers of TGF-B1. And this report says 'intradermal inyection' could be the best way to apply.
This report says to.. if you apply only reducers of TGF-B1 , the reduction of scars are marginally.
Another cite of this report:
If the ratio of TGF-b3 to TGF-b1 and b2 is high, wounds heal without scarring. Antibodies to TGF-b1 and b2 work to reduce scarring, but the antibodies must be given together at time of wounding or shortly thereafter.It has been discovered that treatment with the antibody to TGF-b1 only marginally reduces scarring, and that treatment with antibody to TGF-b2 does not alter scarring at all. If antibodies to all three TGF-b subtypes are given, no reduction in scarring is seen.[15] Reduction in scarring therefore depends on the ratio of TGF-b3 to b1 and b2
Is there any hpoe that our deep scars will be restored very soon ?I'm so depressed !
If any one knows a beneficial treatment for old chicken pox scars pls tell me ,,
All the people here , it's feel that way. You must put you brain in others things. Unfurtanelly we don't have so much in solutions, path there are some good treatments, you must don't give up. There are out there some peellings for you case whit good results, like peeling whit Glycolic acid, up 30% a few times each 15 days, your gonna make good results! don't give up.
In this forum we have talked about peelings, you can search in the search browser, or looking pages on the topics.
There is the review of this site:
http://www.acne.org/glycolic-acid-peel-rev.../232/page1.html
And some threads! :
http://www.acne.org/messageboard/Glycolic-...el-t101901.html
http://www.acne.org/messageboard/lactic-ac...c-aci-t314.html
http://www.acne.org/messageboard/Glycolic-...RN-t176188.html
Pepo I'm currently considering asking my GP to prescribe me an ace inhibitor for a few months.
Maybe whit 20mg at day, the results are much better and quickly.
A small dose of Enalapril at 10mg a day got rid of a full thickness 25year caesarian hypertrophic scar in three month. And almost completed a keloid in the same woman.
In 6weeks a 5% captopril solution, with twice daily application reduced a keloid from 11mm to 2mm. A massive reduction in 6weeks.
Ace inhibitors have been proven to inhibit and block fibroblast proliferation at small doses.
Pepo I'm currently considering asking my GP to prescribe me an ace inhibitor for a few months.
Maybe whit 20mg at day, the results are much better and quickly.
A small dose of Enalapril at 10mg a day got rid of a full thickness 25year caesarian hypertrophic scar in three month. And almost completed a keloid in the same woman.
In 6weeks a 5% captopril solution, with twice daily application reduced a keloid from 11mm to 2mm. A massive reduction in 6weeks.
Ace inhibitors have been proven to inhibit and block fibroblast proliferation at small doses.
By the way, in your report says 'use enalapril whit captopril'??? ,maybe it's good result if use bout at the same time , enalapril 10mg caps 1time at day, and captopril apply 2 times in gel over scar 
hi. Do you think that maybe the solution to our problems over the next decade might be the growing of artificial skin in a lab through regenerative medicine then grafting onto body. For someone like me who has scars from compulsive skin picking all over my body do you think this might be a solution. Ithink we are getting somewhere now with stem cells/ regenerative medicine. I think that by 2020 i will have all my skin back to how it was or even better. please give your opinion. thnks
hi. Do you think that maybe the solution to our problems over the next decade might be the growing of artificial skin in a lab through regenerative medicine then grafting onto body. For someone like me who has scars from compulsive skin picking all over my body do you think this might be a solution. Ithink we are getting somewhere now with stem cells/ regenerative medicine. I think that by 2020 i will have all my skin back to how it was or even better. please give your opinion. thnks
I do not believe that produce skin in a laboratory artificially is the solution, because then you must incorporate it into the course 'hole' of your skin, and in the unions of the patch, if it is not known as eliminating the healing, it should make scar also.
The key is to eliminate the healing, when achieved, not to make lack manufacture skin. the artificial skin is more for people being burned with urgency in putting skin to prevent infection.
what about the finding of the mother of all skin cells , is this gonna help in healing scars ?
I heard the guy who discovered that talk about that in an interview and when asked if he saw it happening that through stem cell treatments skin can be restored he reluctantly said "Yeah....... 
". So I'm sure that if the mother of all stem cells is capable of truly helping and this was aroud the corner he would have said "Oh sure! 
". He said that, btw. That stem cells fixing skin wasn't around the corner. In fact in his opinion it was still far, far, far, far, far, far off and people shouldn't hold their breaths.
Thank goodness we're not dependent on stem cell treatments then, eh? \m/ 
Lol I almost forgot about the whole mother of all skin cells thingy. supposedly it was located in the root of hair follicles or something, shouldn't be too hard to extract, but not so sure where these findings will lead us, it does seem to suggest that its function is to do one thing, grow skin.
The article seemed a bit optimistic to me.. No real clinical results except on rodents, and yet it stated (or in one of the links) that a single injection of HA into a wound should.. or could make it heal scar free. Restylane has been around for years now and has been used to plump up wrinkled or scarred skin.. nobody noticed until now that it could also have an effect on healing wounds..? Still HA is clearly a bit of the puzzle. 
An idea for treatment. Fill out hypotrophic scarring with Restylane or Juvaderm (you can actually buy this of the internet, not having to go to a doctor), then do fraxel or micro-needling on the plumped up skin.
Cited facts:
Scar free healing is here.
Scarring is created by fibroblast proliferation.
Decorin at 200nm has been shown to keep the fibroblasts completely dormant, therefor scar free healing.
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
In 2006 enalapril, which works by inhibiting fibroblast proliferation, by using angiotensin II suppression, completely regenerated a 25year old hypertrophic scar. A cream called captopril another angiotensin II suppression agent, reduced a keloid by 9mm, from 11mm to 2mm in a six week period.
And there is more and more, ECM, we've seen earlier ecm appligraf produce scar free healing, we've seen alloderm etc.
Anyone who comes on to this board and talks as if scar free healing is not here to is talking shit...
Cited facts:
Insulin injected 4times a day into a 3x3cm scar completely regenerated an indented scar to normal skin with no discernable scar whatso ever. This was backed up in 2009 study when Linge proved significant reduction in scar with 'one' injection of insulin.
4 TIMES A DAY? 
If shot four times a day for months, you destroy the skin puncture.