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I'm currently using Epiduo Forte and been doing so for a couple months now and I would say it's the most effective topical I've had in a while but the most drying. It really works in calming down the inflammation of those angry pimples, it even stopped a painful cyst from fully developing. However it's not something I can use everyday because it makes me peel A LOT & it makes my makeup look so freakin bad and flaky when I do use it!! That's the only downside to it for me, so I say definitely give it some hope :)!