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On 1/10/2022 at 1:08 PM, SaffronAide said:Please guys take the microbiome and SIBO tests.
This is what I would maybe look into.
I brought this up a few posts back.
A few things to take note of,
This is looking at the small intestine, not large intestine or colon, this is not a fecal sample, these are fatty acids from bacteria that can apparently be measured from a blood sample.
its a finger prick dry blood test.
The only main issue is that the lab is in Slovenia, I was sent a test kit through standard mail and it took a very long time to receive, over a month, and then I screwed up the test which invalidated it, but im probably going to try to order another one through a health practitioner overseas that has access to UPS or FedEx.
Notice both bifido and propionibacterium freudenreichii are on the list of standard resident organisms, P. acnes is not.
They can distinguish P. acnes from p. freudenreichii based on the bacteria's fatty acid profile.
Here's the science,
CHROMATEST-ENGLISH-PUB-Q3-2020-1.pdf
Welcome to Chroma Test “ the official representative of the œLaboratory of Microbial Chromatography in the European Union!
I was at the doctors office today and got my blood drawn. I got frustrated because it took him so long just to do a blood test and also I had to convince him that he determines allopregnanole and I dont know if its done with those blood samples.
I also spook with him about progesterone and he thinks it's a treatment option. I ordered progesterone cream yesterday and will start applying it when it's there. I know I said I only do things in agreement with my doctor, but doctors got me into this mess, I cannot stand the brain Fog any longer, and also my doctor seemed more to care about an explanation how it is possible I still have side effects if the drug is already out of my system for 9 years now.
So I will put 10 mg of progesterone cream everyday for 2 weeks on 4 days off for 5-6 months as it's advised for people who suffer from Post Finasterid Syndrom. The 4 days off seem to be crucial as there are ups and downs when taking it and you bounce back stronger during those days.
I will keep you updated.
EDIT: I just read that people who were successful on this protocol also took a T booster. The guy who created the protocol took Tongkat Ali and I just ordered it and will also take it.
Thx for info Thommy- hope this protocol works out for you!!
Im so over the brain fog too, seeing endocrinologist end of the month. A want a comprehensive blood test done inc looking at progesterone as it appears to be the missing link for us - lets hope so!!
I will also discuss that Leydig cell death hypothesis which sounds scary, godhelp us if its that because I dont know theres a way out.
I know theres the risk of baldness with going on any TRT program, not sure I give a fuck anymore, weve been patient all of us, most issues in life you get an answer eventually, going thru this shit for 20 years has been mind boggling, anyone associated with making Accutane can go fuck themselves.I want oily skin again, hair that isnt dry and brittle, even bring back acne for all I give a shit - just give me drive, energy and clarity of mind and a stronglibido
22 hours ago, luk55 said:Yes. Serum blood test. For me it was totally normal. The result said 45 and the norm was 30-60.
Did they do serum retinol/vitamin A at the same time?did u test low normal as well? I have not seen anyonepost high normal as yet.
I remember reading on that anti A forum that under_tow talks about, there was a girl who was a previous accutane patient, who after cutting out vitamin A had levels go wellbelow range. I think she reported no improvement.
Guys, by the way, has anyone here have strong PAS but:
- High Total and Free testosterone here?
- High- normal LH?
- And high- normal IGF-1? 200- 350
- DHT?
Anyone here 600 ng\dL of Total Testosterone and has severe PAS?
OR
5+ miUL of LH? 5- 7 LH?
Can you please share your results here on the comments.
On 1/16/2022 at 6:09 AM, Calcified said:Did they do serum retinol/vitamin A at the same time?did u test low normal as well? I have not seen anyonepost high normal as yet.
I remember reading on that anti A forum that under_tow talks about, there was a girl who was a previous accutane patient, who after cutting out vitamin A had levels go wellbelow range. I think she reported no improvement.
The problem with serum, aka blood testing is that it's not an accurate depiction of what's really going on. You need tissue samples, such as hair, or saliva. Those would indicate low retinol levels post accutane. It doesn't surprise me at all her levels were very low.
For me, if I do beef liver by itself I have a bad reaction. But if I take it with laminaria, broccoli sprouts, and black currant, there is zero bad reaction to it.
I can recall that when I first started using my machine, and before beef liver use, the machine always indicated Bornholm eye disease. After a while of taking beef liver, that eye disease disappeared and hasn't returned. That tells me that my body considered my eyes to be the top priority for retinol replenishment, and now the rest of my body is catching up.
10 hours ago, Dragon76 said:The problem with serum, aka blood testing is that it's not an accurate depiction of what's really going on. You need tissue samples, such as hair, or saliva. Those would indicate low retinol levels post accutane. It doesn't surprise me at all her levels were very low.
For me, if I do beef liver by itself I have a bad reaction. But if I take it with laminaria, broccoli sprouts, and black currant, there is zero bad reaction to it.
I can recall that when I first started using my machine, and before beef liver use, the machine always indicated Bornholm eye disease. After a while of taking beef liver, that eye disease disappeared and hasn't returned. That tells me that my body considered my eyes to be the top priority for retinol replenishment, and now the rest of my body is catching up.
I honestly think my own personal exposure has caused my body to stay in a fixed state that still thinks I'm on accutane.
The study guitarman01 refers to regarding high retinol in skin, I suspect if you take accutane long enough skin retinol may godown as with time italmost impossible to tell I was on accutane.
I think why mydryness reducedtowards the end of treatment is a important piece of the puzzle.
Accutane is not still in me but my body make think it is.
Some forum of Retinol resistance?
I got my first result of my blood test.
My progesterone is way too high! My value is 0.64 nmol/l and it should be < 0.16-0.48. The guy Ronnie who took Mifepristone had a value of 0.11 nmol/l and his scale was 0.002-0.159. So if I take his scale my value is 4 times the upper limit.
This means my progesterone is not converted into 5-Dihydroprogesterone, which means my 5 Alpha Reductase 1 is not working. This is some proof for our theory that 5 alpha reductase 1 is inhibited permanently. I'm still waiting for my Allopregnanolone value, if its coming out low, definitely its proven.
I made all these values before I took progesterone. I took progesterone the last 4 days and will definitely stop now.
This is the study which was the basis for the mifepristone treatment of Ronnie: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030330/
Everyone who's interested can read it, I will read it now, my doctor will also read it.
Restore your systemic retinol levels while simultaneously detoxing accutane and the 5 alpha reductase issue is resolved. See the link below.
7 hours ago, Dragon76 said:Restore your systemic retinol levels while simultaneously detoxing accutane and the 5 alpha reductase issue is resolved. See the link below.
I'm not getting much out of this link, it's very complicated. Furthermore it says it feminizes the Enzym, do you know what this means?
Also have you determined your progesterone levels and Allopregnanolone that you can say your 5 alpha reductase 1 is working again?
My progesterone is 4 times the upper reference, this explains why I feel this way and mifepristone is the only drug on the market which is antiprogesterone and we have one guy who says he is cured by it.
Your progesterone is high because of the p cream you were using. Take a break from it and your p levels will fall. My dht hasn't normalized yet, but I believe with daily retinol intake from beef liver it will.
mifepristone affects far more than just progesterone and I'd avoid it like the plague. Everyone is free to use more toxic pharmaceuticals if they wish but I know better.
The study said atra had a positive influence on dht production. Atra is found in beef liver. I've learned over the years that the body always prefers whole foods over synthetic isolates. My machine aways prioritizes whole foods over synthetic isolates. Good enough for me.
31 minutes ago, TrueJustice said:Thommy
Surely your endocrinologist is guiding you on what to take yeah?
Youvedone the tests, what are they advising you to now do?
Well, I did the values at my general practitioners who is also a pharmacologicist. We had a call yesterday and he said he wanted to wait for the value of the Allopregnanolone. Also he hasn't read the study about mifepristone yet. But he said if the value of the Allopregnanolone will be too low then we could try to regulate it. The only two things on how to do that which we talked about yet is the progesterone with tongkat Ali and the mifepristone. I believe I will do one of those two things most likely, I will see. He will contact me next week and I will let you know what I do.
Also I will read more about mifepristone in the meantime. Like dragon said its doing many things like sth with the HPA axis and I wanna fully understand it.
I joined the whatsapp group of saffron Aide and people over there are ordering mifepristone right now.
Also there was one guy from Reddit who took a T booster and progesterone and felt better.
So it comes down to those two things hopefully I'll take the right one and recover.
No worries- thx for info, pls keep us updated
I find it very fucking hard to believe that we should need to take Mifepristone an abortion drug to fix things, surely Im not the only one who thinks thats just plain mental??
Testosterone and progesterone I get but mifepristone,come on
The liver processes progesterone into it's downstream metabolites via cytochrome p450. If cytochrome p450 is under active, you end up with excess progesterone and low progesterone metabolites.
Cruciferous veggies are excellent for activating liver cytochrome p450. Broccoli sprouts capsules are cruciferous and available at Amazon and other online retailers.
The problem with testosterone cream is that it shrinks the balls down to nothing, you have to make sure you're inhibiting aromatase, and it's been known to cause cancer.
My machine indicates excellent testicular function. Our issue with low testosterone stems from brain gut and liver dysfunction.
2 hours ago, TrueJustice said:No worries- thx for info, pls keep us updated
I find it very fucking hard to believe that we should need to take Mifepristone an abortion drug to fix things, surely Im not the only one who thinks thats just plain mental??
Testosterone and progesterone I get but mifepristone,come on
I just looked up the following:
In people with depression there is an upregulation of the HPA axis. (Hypothalamus/pituitary gland/Adrenal gland axis). The HPA axis works like this: The hypothalamus secretes CRF which activates the secretion of the ACTH in the pituitary gland. This activates the secretion of glucocorticoids like cortisol in the Adrenal glands. Cortisol interacts with two receptors in the brain the glucocorticoid receptor (GR) and the Mineralcorticoidreceptor (MR). This inhibits the further secretion of CRF which is called negative feedback loop.
Now according to the study I posted retinoic acid (related to isotretinoin) causes HPA hyperactivity. First there was a higher concentration of cortisol which was normalized by mifepristone. Also the behaviour of the rats in the experiments could be normalized by mifepristone and the negative feedback loop was impaired by the retinoic acid which could be normalized by mifepristone.
Besides that the retinoic acid changed the histology among other things the protein expression of Glucocorticoid receptors. That could also be an explanation of the long lasting effect. Because when there is an abolition of the negative feedback loop on the glucocorticoid receptors this also leads to HPA hyperactivity. All these histological changes could be normalized by mifepristone.
At least I have a basic understanding of it now.
5 hours ago, TrueJustice said:Males taking Mifepristone, is that just unique to Accutane. I mean is it now common for men to take to treat depression or something who have nothing to do with Accutane?
What an experiment ha ha
Don't think it's gonna help me. Best to get gp to test, mine not high.
Taking Mifepristone sounds hell risky.
I agree completely with calcified about the riskiness, atleast for short term health while on it. On another note, I think a lot of accutanes long term issues are based on what nutrient deficiencies may have existed when you took accutane.
When I was a kid, I was big on meat, dairy, fruits, grains, nuts, some veggies, and I got a daily Flintstones multivitamin from mom. Wasn't much into fish (although I loved tuna, but never got any), eggs, or crucifers. I think that left me wide open for accutane damage because those three foods have nutrients I believe are crucial for shielding the body from accutane effects and detoxing it from the body. Omega 3, lecithin, and glucosinolates such as sulforaphane. Just made a change to the program.
Daily supplements
Carnitine
Fish eggs
Broccoli sprouts
Raw beef thyroid
Vitamin c gummies
Diet
Omnivore
Non GMO
Organic when possible
Avoid
Soy
Gmo
Stevia
Alcohol
Caffeine
Tobacco
Cannabis
Artificial sweeteners
Artificial preservatives
Will report good or bad results in the coming weeks.