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I am pleased to report that I no longer have bone pain, after 7 months of taking accutane, the pain that was mild and I think it was due to accutane, already disappeared about a month and a half ago.
Current bowel problems: highs and lows.
Diet: none, I still eating everything.
Greetings 
On 3/20/2021 at 2:53 PM, k3tchup said:I can see the full text article because of my school's library, but you won't so I will link to the abstract:
https://pubmed.ncbi.nlm.nih.gov/23962262/
That said, this paper in the International Journal of Dermatology proves your hypothesis of excessive, long term serotonin syndrome to be false and opposite.
Here is an exert from the paper:As a result, isotretinoin increases the expression of postsynaptic D2 dopamine receptors and simultaneously activates the transcription of tyrosine hydroxylase (TyrOHase, which plays a role in dopamine synthesis) and the transcription of monoamine oxidaseB (MAO, which deactivates dopamine after reuptake into the cell). As a consequence, a relative dopamine deficiency develops in the affected neural networks. Furthermore, ATRA stabilizes the mRNA and inhibits the degradation of the 5HT1Areceptor, thereby increasing its presynaptic concentration, enhancing serotonin reuptake and causing inhibition of serotonin secretion. In addition, isotretinoin increases the intracellular concentration of serotonin transporter (SERT) by both stabilizing its mRNA and inducing the expression of relevant genes. The SERT takes part in the reuptake of synaptic serotonin. In combination, these processes decrease serotonin signaling.
You don't have serotonin syndrome and probably have the exact opposite.
I wish you luck in your dopamine quest and that you don't cause any down regulation of your own production; however, that may not be possible anyway due to enzyme activity converting L-phenylalanine to L-tyrosine to L_DOPA as it maybe a rate limiting reaction anyway. And even if you produce more, you need receptors for them to bind to which accutane could have permanently altered making dopamine less effective.
You're pretty much saying that we are doomed because of our possible permenanently altered dopamine receptor ?
I believe the dopamine receptor dysfunction is temporary as long as accutane remains trapped in the body. Once removed dopamine receptors return to normal. Vitamin A regulates the dopamine system. With a lack of true vitamin A due to accutanes presence, dopamine is easily depleted and serotonin levels become excessive. I have the blood test to prove excessive serotonin, ie serotonin syndrome. It never ceases to amaze me when retards such as ketchup come on here and attempt to argue with bonafide blood test results.
Regarding retinol intake, I can handle dairy products no problem. I wouldnt survive without dairy.The only thing that causes issues for me are whole beef liver and cod liver oil. to to be honest, beta carotene is a much safer and healthier way to get your vitamin A because you never have to worry about getting too much, as long as it's from food.
I agree with unionjack about the drug being trapped in the body and the importance of bile flow. A lot of those foods mentioned above are fiber rich. Fiber depletes cholesterol, which many accutane people struggle to maintain.
I'm trying a combo of brown seaweed pills and horseradish root pills. Will report back later.
On 11/7/2021 at 9:36 AM, Aaron76 said:I believe the dopamine receptor dysfunction is temporary as long as accutane remains trapped in the body. Once removed dopamine receptors return to normal. Vitamin A regulates the dopamine system. With a lack of true vitamin A due to accutanes presence, dopamine is easily depleted and serotonin levels become excessive. I have the blood test to prove excessive serotonin, ie serotonin syndrome. It never ceases to amaze me when retards such as ketchup come on here and attempt to argue with bonafide blood test results.
Regarding retinol intake, I can handle dairy products no problem. I wouldnt survive without dairy.The only thing that causes issues for me are whole beef liver and cod liver oil. to to be honest, beta carotene is a much safer and healthier way to get your vitamin A because you never have to worry about getting too much, as long as it's from food.
I agree with unionjack about the drug being trapped in the body and the importance of bile flow. A lot of those foods mentioned above are fiber rich. Fiber depletes cholesterol, which many accutane people struggle to maintain.
I'm trying a combo of brown seaweed pills and horseradish root pills. Will report back later.
''Accutane remains trapped in the body.'''
This is beyond bro science, it is insanity.
I explained the real cause of PAS above.
Your AR expression is downregulatedin your brain and on your genitals. Dopamine issues is the result of that, not the main CAUSE.
That creates an ordeal of problems. Damages prostate, damages the connection of prostate to the muscles on perineum and creates a bad feedback loop. (That's why some PFS or PAS sufferers healed with Pelvic Floor release exercises, for some it is just a bad feedback loop after the inital genetic alteration fixes itself in short time but struggles to heal the connection with the muscles.)
That's why TRT and HCG won't work for %90 of PAS people but works %90 for the PFS cases. PFS is Upregulated AR. We need the opposite.
And only AR antagonists like Bicalutamide (Much safer than Fin)can fix your gene expression. Or daily L- Carnitine (Which also upregulates AR)INJECTIONS intoyour veins. (Goodluck with that.)
You are wasting your whole life with your senseless and crazy theories, i feel sad just by reading your comments. You need to see a good therapist and wake up from your ramblings.
A PAS friend of mine even tried Finasteride to upregulate AR, and you now what? He felt a sensivity on his genitals like he never did before, he may have fully recovered if he continued but he decided to stop as the improvements didn't increase and for other reasons unrelated to health. We also know 4 people in total healed from PAS wtih Finasteride which one of them was a Dr. (Kevin Pezzi)
Any sane personwould be already aware that a good diet won't cure your PAS after being on it for YEARS. You are wasting your LIFE while you can\ mayrecover easily within a MONTHwith the drug i mentioned.
I am currently trying to get it after my TRT protocol ends.
Seriously guys, wake up.
Dude, look at unionjacks post at the top of the page and get a clue. What he says makes far more sense to me than anything you're saying. Malfunctioning liver and gallbladder, which we're all dealing with, has nothing to do with androgen receptors.
It's not just diet, and it's not just supplements. It's both. I hate bitter tasting foods because I'm a supertaster, and so I'm using horseradish root capsules. And liver function has improved. Look at unionjacks honest info.
No sane person would contaminate their body with a toxic poison like propecia. Sorry.
Only an idiot would use an anti androgen. Accutane is anti androgen. Anti androgens make things worse, not better.
Saffron I'd you're so into these anti androgen garbage then why don't you use them? If they are so great then why aren't you cured?
Carnitine has been shown to upregulate androgen receptors. I've tried carnitine several times and guess what. It stimulates MASSIVE dopamine loss. Not exactly helpful.
Also, ive seen propecia guys try pro androgenic herbs and pharmaceuticals and they do nothing for them.
5 hours ago, Aaron76 said:Dude, look at unionjacks post at the top of the page and get a clue. What he says makes far more sense to me than anything you're saying. Malfunctioning liver and gallbladder, which we're all dealing with, has nothing to do with androgen receptors.
It's not just diet, and it's not just supplements. It's both. I hate bitter tasting foods because I'm a supertaster, and so I'm using horseradish root capsules. And liver function has improved. Look at unionjacks honest info.
No sane person would contaminate their body with a toxic poison like propecia. Sorry.
Only an idiot would use an anti androgen. Accutane is anti androgen. Anti androgens make things worse, not better.
Saffron I'd you're so into these anti androgen garbage then why don't you use them? If they are so great then why aren't you cured?
Carnitine has been shown to upregulate androgen receptors. I've tried carnitine several times and guess what. It stimulates MASSIVE dopamine loss. Not exactly helpful.
Also, ive seen propecia guys try pro androgenic herbs and pharmaceuticals and they do nothing for them.
There are different cases for sure. I personally don't have any liver or galbladder related symtpoms. But those things alone can not cause prostate issues and ED.
You may have liver issues on top of AR expression issues, and you know what organ also needs proper AR expression to function properly?
Liver.
5 hours ago, Aaron76 said:It's not just diet, and it's not just supplements. It's both.
And what did they do to you? Nothing. You still have PAS.
5 hours ago, Aaron76 said:their body with a toxic poison like propecia.
I literally said it two times that do not take Finasteride in my posts. I have found a safer alternative which is a non- steroidal AR antagonist. I also said that i am currently trying to obtain it.
5 hours ago, Aaron76 said:Anti androgens make things worse, not better.
So please explain why many PAS cases had no results with HCG and TRT etc.
We have downregulated AR, two studies on Pubmed already showed that Accutane usage causes DOWNregulated AR expression on back skin of the patients. Probably, all over on the body too.
5 hours ago, Aaron76 said:Also, ive seen propecia guys try pro androgenic herbs and pharmaceuticals and they do nothing for them.
Wrong. Because those people who didn't improve were doing the protocols wrongly, i know everything. For PFS it is 100% works when you take androgens on CORRECT doses and with correct protocols. I already have a huge archive of recoveries with HCG and whatnot. Countless PFS cases who healed with androgens...
I have a close PAS friend who used an AR upregulator Warfarin and almost recovered but he quit due to that drug being a blood thinner and he needed a Dr. to consult about it and for other family reasons.
Evidence is here, and in this thread too, who took Fin and recovered from PAS.
I tried every androgen out there with no results and guess what improved me only? Progesterone.
Another anti androgen on high doses and i took high doses, daily. It was a weak AR upregulator so it didn't continue to improve me. But i was %50 recovered at that time.
I was close to killing myself before that event, and i saw the light at the end of the tunnel. I never get sad or hopelessafter that day. I know this is reversible. And i know HOW to reverse this.
Another, first hand evidence.
This is not rocket science, it is clear that we have dysfunctional ARs from symptoms that we present and we now from studies that Accutane downregulates AR. So what we can do to fix this?
Upregulate it back.
What causes UPregulation of ARs?
AR Antagonist's.
The end.
In life you have to take big steps in order to improve, diet and supplements are not the big step we are talking about. You are going to die with PAS and will never recover if you guys keep on trying useless methods.
If it works, that's great for you. But people are trying supplements here for YEARS with no results, that's what im talking about.
I am saying this, anyone who took Accutane and has mainly sexual issues, the cure is AR upregulators, Anti- Androgens.
I did my job, my responsibility is to show you guys the most possible fix of PAS. My conscience is clear now.
And if any one of you would listen to me and try this theory out with me, this thread would be already closed because we would already find cure..
On 9/6/2021 at 10:36 PM, Aaron76 said:I've tried probiotic rich foods such as kefir, kimchi, and raw saurerkraut. I've tried prebiotic rich foods such as raw and aged garlic. I've used whole organic ginkgo. Out of all of those, the whole organic ginkgo powder that I get from Amazon and encapsulate at home is by far the best. Love the way it makes my brain feel. Better than any drug or herb I've ever used.
The hope is that rapaflo rx can restore things down below. My pelvic region has always been extremely up tight post accutane. Drugs like flomax and rapaflo help to get the pelvic region, including prostate and penis, to relax. Longer and thicker penis, better sexual functioning, except that nothing comes out after orgasm, from what I've read. Will update the board after I have the Rx and have used it a while.
Have you ever tried PC muscle relaxation too? For longer periods? For brain issues i recommend Progesterone. It increases GABA. PFS people use it with sucsess.
I admire the information you share in these posts, don't get me wrong. We are here to help each other.
Btw, which is better Rapaflo or Flomax? I may try these just to see. I use Cardura xl sometimes and it only works for my flaccid size.
But not for erections, sensivity and orgasms and perineum muscle strength. My pelvic floor area has no contraction when im erect. Back then thatare waslike metal contracted strings.. Between my legs, below testicle area...
I am pointing out that your issues may resolve with an AR- upregulator it is all connected.
BTW
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385916/
Tamsulosin can damage the testicles..
I've used saw palmetto, beta sitosterol, pumpkin seed oil, pygeum, nettle, vitamin B2, biotin. These are all anti androgens. And guess what. They all made me worse.
Ive use cardura, minipress, flomax and rapaflo, and I would not recommend any of those to anyone. They were at best worthless, and at worst, the last two cause retrograde ejaculation.
I agree completely that androgen receptors are messed up, and I agree completely that the damage can be reversed. I disagree about the use of more toxic pharmaceuticals. And I disagree that that is the primary issue.
I need to be completely honest here. I haven't disclosed the following until now. Several years ago I took a comprehensive blood, hair and urine test from Quest diagnostics that not only indicated excessively high serotonin levels, but it also indicated excessively low magnesium and thiamine. I went to the store, got some thiamine and magnesium malate, and guess what. They completely wiped out my dopamine levels and I had to stop in under a week. Worthless test right? Not so fast.
Fast forward a bit to my biofeedback machine results. Almost every scan, two supplements that usually pop up are biocalcium and lecithin. What do these two things do? They protect dopamine. What does thiamine do? It eliminates excessive serotonin.
There are several different ways to use the medicomat biofeedback machine. You can rely on the machines lists of recommended foods, drugs, and supplements. Or you can go more in depth, and scan on any organ or tissue in the body, and click on vitamin lists, mineral lists, and amino acid lists.
I consider the hypothalamus and pituitary to be the body's Central processing unit, or cpu. When I click on that area and click on vitamins and minerals, I consistently get magnesium, calcium, choline, and thiamine recommendations. This confirms the quest diagnostics blood test results from a while back.
Interestingly, the machine consistently lists the progesterone herb wild yam in the recomended supplements section. I've tried wild yam and the benefit is slight, but noticable, but not strong enough to consider it useful.
I absolutely 100% believe the drug is radioactive, and becomes trapped deep inside the cell on the rxr and rar receptors inside the cell nucleus. This would explain why my machine likes cruciferous veggies so much. They are rich in sulforaphane, which is known to reach deep inside the cell nucleus and grab unwanted things that don't belong there and pull it out. It would also explain why my machine likes laminaria so much, which is known to detoxify radioactive material from the body.
These whole foods are simply not enough to get it out. There's an intracellular detox process inside the cell that must happen in order to draw accutane from the nucleus and into circulation, and I believe thiamine and magnesium play central roles with this process. Nadph is a part of this.
I was born heterosexual. Was always strictly heterosexual up until accutane use. But sometimes after accutane use i would have homosexual thoughts from time to time. This is extremely common with accutane I believe.
Yesterday I took those 4 supplements, choline, b1, ancestral supplements living bone (calcium), and magnesium malate, and guess what. Raging homosexual thoughts. Why? What was happening here? I believe the drug was being drawn out of the cell nucleus and into circulation, leading to the extreme psychological changes.
Right now I'm doing those 4 supplements daily and will see how it goes and report back later. I'm pasting a link from a guy who agrees with me about the importance of thiamine for recovery below.
https://www.hormonesmatter.com/astronauts-iuds-intracranial-hypertension-pseudotumor-cerebri/
Do a page search for accutane and the pertinent info will be found.
13 hours ago, Pido said:I'm all for AR upregulation, but using anti androgendoesn't sound good at all. Maybe I'm just ignorant.
yeah I feel the same. I applaud the risk taking with this approach but I also fear the side effects that would most likely come with taking such a drug.
Im more inclined to try TRT now that my lvls have dropped, going for another blood test over coming days just be sure
I have a sneaking suspicion our HPA is permanently fucked so regardless of our approach, its all just a bandaid solution. What do you do.
15 hours ago, TrueJustice said:yeah I feel the same. I applaud the risk taking with this approach but I also fear the side effects that would most likely come with taking such a drug.
Im more inclined to try TRT now that my lvls have dropped, going for another blood test over coming days just be sure
I have a sneaking suspicion our HPA is permanently fucked so regardless of our approach, its all just a bandaid solution. What do you do.
I have tried TRT in the past, it was very hard to balance hormones. Would be interesting to hear if you get any benefit from it.
I've been back and forth a lot over the years about the drug still being in the system vs permanent damage. I agree completely with truejustice about hpa being a central issue. Another term for that would be autonomic imbalance, in which the fight or flight sympathetic system is overactive and the parasympathetic rest and digest system is under active.
I've tried a lot of herbs over the years, and as of right now I would rank wild yam ahead of all others, including ginkgo.Wild yam is more than just for progesterone. I believe testosterone is involved as well. Its antispasmodic, and also anabolic. It's know to calm the autonomic nervous system. Wild yam has always ranked high with my machine's supplement recommendations. I always thought it was for women only and largely ignored it until recently. It's for men as well.
I took some wild yam before bed last night and so far nothing bad. Sexual thoughts are strictly heterosexual. No big improvements physically but mentally my mind is in a state of peace and calm. Will stick with this for a while and report back later.
8 hours ago, Calcified said:I have tried TRT in the past, it was very hard to balance hormones. Would be interesting to hear if you get any benefit from it.
One protocol mentioned to was:
Testosterone
DHEA
Pregnenolone
Melatonin
So we call it TRT but its more than just taking Testosterone. Getting blood test today
On 11/10/2021 at 11:47 AM, Pido said:I'm all for AR upregulation, but using anti androgendoesn't sound good at all. Maybe I'm just ignorant.
It does not ''sound'' good but it is the reality. I tried various androgens with worsenings or with no results. It is clear, and as i said before here, only improvement i ever experienced was when i was on Progesterone, a known anti- androgen on higher doses.
On 11/11/2021 at 4:21 PM, Calcified said:I have tried TRT in the past, it was very hard to balance hormones. Would be interesting to hear if you get any benefit from it.
Two days ago i completed my own TRT trial. And i have no improvements on the sexual department.
My voice has deepened above baseline. I sweat more, i stink more. Beard may be growing better.But nothing else. I was also on HCG and HGH. I still use HCG and will do a PCT this week with Clomid or Tamoxifen. I even tried taking Arimidex on my last week to see if it changes anything, nothing. My E2 didn't skyrocket on Test either. It was 38 pgml. Still i wanted to try an AI.
Im telling you guys, the cure of PAS is AR upregulation. I have seen the EVIDENCE, have read reports, studies, talked with people.
You guys can also try Mifepristone. Ronnie recovered with Mifepristone after 17 years of suffering from PAS. It resets all the receptors and glucocorticoid system which is affected by Tane'. And guess what, Mifepristone is also an ANTI- ANDROGEN!
ANTI ANDROGENS, UPregulate Androgen Receptors.
That's why Post Finasteride Patients have UPregulated ARs and they downregulate them with Androgens to heal. And it works for them.
On 11/10/2021 at 7:04 PM, Aaron76 said:saw palmetto
Ditch the rest, they may be just slightly anti androgenic, nothing significant to have a real impact.
The reason you got worse is because you reduced your 5AR2 activity. Saw Palmetto inhibits 5AR2! NOT ARs.
It is different. It is not the same thing.
You need a DIRECT agent to antagonize ARs solely without enzyme inhibitons or hormonal alterations. Bicalutamide does that.
It is not a good idea to take Saw Palmetto or Fin. Our issue is not DHT related like PFS. Accutane only affects 5AR1 expression as far as we know, only on skin.
hot flashes or flushing
bone, back, or pelvic pain
muscle weakness
muscle or joint pain
headache
shortness of breath
increased blood pressure
swelling of the hands, feet, ankles, or lower legs
cough
constipation
nausea
vomiting
abdominal pain
diarrhea
gas
change in weight (loss or gain)
loss of appetite
dizziness
pain, burning, or tingling in the hands or feet
difficulty sleeping
feeling of uneasiness or dread
rash
sweating
inability to get or keep an erection
need to urinate frequently during the night
bloody urine
painful or difficult urination
frequent and urgent need to urinate
difficulty emptying bladder
painful or swollen breasts
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
yellowing of the skin or eyes
pain in the upper right part of the stomach
extreme tiredness
unusual bleeding or bruising
lack of energy
upset stomach
loss of appetite
flu-like symptoms
dull or sharp side pain
chest pain
thats a list of bicalutamide side effects. Saffron if you want all that, go for it. I think I'll pass. Will let the board know in the next month or so if the natural hormonal precursor wild yam is or is not a long term solution.
Aaron, thanks for sharing that. Very important we understand the full list of potential side effects before going down this path.
Before you and Saffron debate again on this subject, could I mention that you may not have to take Bicalutamide for long to get desired result. Do you think thats something to consider in all this? Or would you still never consider taking it??
Truth told, you could read that list of side effects in a Pfizer jab, none of which I suffered from. Perhaps we need to weigh up the risk vs reward with AR upregulation drugs
I won't consider any pharmaceuticals because unionjack already said it best up top. It's a bile flow issue. I think accutane victims have been put into a state where we crave saturated fat and despise soluble fiber.
Wild yam is a bitter herb that stimulates bile production and flow. A lot of people cannot stand the taste of bitter foods. Daily wild yam capsules are a solution for that. I'm not making any promises but to me wild yam seems like the best hope for recovery.
My biofeedback machine has been an extremely frustrating thing to work with. All of its food recommendations rank far above the wild yam supplement, but guess which one my body seems to tolerate the best. You guessed it, wild yam. I'll provide good or bad news regarding wild yam in the coming month or two.
Question - who else (male) has urinary issues? If so, what?
I basically have the symptoms of a large prostate but got checked before and it was apparently normal.
But I have to pee often, have a weak flow and struggle to start. Im really anxious about peeing in public, to the point where I cannot go at a urinal.
Hey indigo, ive had prostate issues ever since accutane. I believe the issue stems from the liver. Once you get bile flowing adequately again the issue should resolve. Unionjacks post above seems to confirm this. The problem with that post is that a lot of accutane people have no interest in a high fiber diet. Saturated fat is what our bodies want.
The solution I hope is wild yam capsules, thrice daily. Continue eating the ketogenic foods your body is asking for, but add in the wild yam capsules, and the hope is it will be enough to get bile flowing again.