6 hours ago, TrueJustice said:

I agree. Im more inclined to ask, what has it altered this drug??

Idput money on that its long gone but that it fucks up things like how our bodies use Vit A years later

Ive long given up thinking I need to detox isotretinoin, that doesnt mean though my bodyknowswhat to do with Vit A.personally I think its messed up how I process it and all the complications that come with it

That is a more reasonable option, the function of this substance is to kill sebum stem cells with toxicity, so I could bet that the damage that this substance causes is cell damage.

These symptoms give us the signal that something is wrong with the liver, taken from a book.
- Impotence
- Urinary problems
- Vision problems
- Liver spots,
especially those in the
front of the hands and the
expensive
- Excess weight or weakness
- Dark color under the eyes
- Scoliosis
- Stiff neck
- Dental or gum problems
- Numbness or paralysis of
the legs
- Osteoporosis
- Kidney diseases
- Alzheimer's disease
- Greasy hair or loss of
hair
- Nightmares
- Digestive disorders
- Clay-colored stools
- Hemorrhoids
- Liver cirrhosis
- High cholesterol
- Brain disorders
- An annoying personality or
"Biliosa"
- Other sexual problems
- Hormonal imbalances
- Puffy eyes
- Dizziness and episodes of
fainting
- Severe back pain and
shoulders
- Impotence
- Urinary problems
- Vision problems
- Liver spots,
especially those in the
front of the hands and the
face Excess weight or
weakening
- Dark color under the eyes
- Scoliosis
- Stiff neck
- Dental or gum problems
- Numbness or paralysis of
the legs
- Osteoporosis
- Kidney diseases
- Alzheimer's disease
- Greasy hair or loss of
hair
- Nightmares
- Digestive disorders
- Clay-colored stools
- Hemorrhoids
- Liver cirrhosis
- High cholesterol
- Brain disorders
- An annoying personality or
"Biliosa"
- Other sexual problems
- Hormonal imbalances
- Puffy eyes
- Dizziness and episodes of
fainting
- Severe back pain and
shoulders
- Drop
- Asthma
- Yellow skin and eyes
- Obesity
- Cold extremities
- Joint hardness and
muscles

I used to feel reassured that the liver has this incredible capacity to heal itself.

What happened to ours?

On 8/8/2021 at 4:49 AM, TrueJustice said:

Would it be wrong to say, increase testosterone and insulin issues would be fixed, fatty liver would improve, fatigue and depression would improve, oil would return back to the body?

Now how you go about increasing testosterone is the question, trying to do naturally seems to have limited results

Have tolook at other options, gels and/or injections etc

If your tissues are insulin resistant and you manage to fix it, that would solve most problems including hairloss.

https://www.researchgate.net/publication/41403764_Short-term_isotretinoin_treatment_decreases_insulin-like_growth_factor-1_and_insulin-like_growth_factor_binding_protein-3_levels_Does_isotretinoin_affect_growth_hormone_physiology

"In human dermal papilla cells, alltrans -retinoic acid induced a fi vefold increase of IGFBP-3, which inhibited IGF activity important for maintaining hair anagen growth"

https://www.researchgate.net/publication/5407789_Effects_of_pioglitazone_on_erectile_dysfunction_in_sildenafil_poor-responders_A_randomized_controlled_study

pioglitazone could improve erectile dysfunction

https://www.sciencedirect.com/science/article/pii/S1110569014200550

"These findings show that increased sensitivity of testicular cells to insulin mediated by the PPAR agonist pioglitazone restores testicularhistomorphometryand improves semen quality in diabetic rats, despite the weak effect of thisglitazoneon blood glucose. This suggests a role forinsulin sensitizersand improvedinsulin signallingin the amelioration of testicular lesions and regulation of spermatogenesis in the diabetic state, and lends support for insulin at promoting testicular functions."

I'm about 3 weeks on pioglitazone now and my libido has improved significantly. My weight fluctuates a bit because of water retention. This drug should be able to restore the skin barrier function so it can hold moisture. It should also fix any gut issues because it reduces neutrophilic infiltration in the intestines (this kills necessary bacteria)and restores microbiome. I will report back later, but i think this might just work for me.

Interesting findings there Lifesuckshard, they definitely backup your reason to go on pioglitazone

You are making me rethink my next move but I really dont want to go on another drug or at least have fear of going on another one.

Do you plan to be on it for life? Similar to testosterone treatment, will you just revert back to feeling crap if you stop taking it?

Any other side effects beside water retention?

Daily supplements
Alpha GPC 1.2g/day
Vitamin c gummies, as desired
Organic Dijon mustard, as desired
Metabolic maintenance calcitrate, 1g/day

so far I'm definitely dreaming more than I was, which was never. Brain definitely feels better. Less stressed. Not much benefit physically to report yet. Noticed an ammonia odor to my stools. I've read multiple reports that accutane attacks the bones, thus the calcium citrate for bone repair. Alpha GPC should over time help with liver repair since it's a major choline donor. Will keep the board posted.

10 hours ago, TrueJustice said:

Interesting findings there Lifesuckshard, they definitely backup your reason to go on pioglitazone

You are making me rethink my next move but I really dont want to go on another drug or at least have fear of going on another one.

Do you plan to be on it for life? Similar to testosterone treatment, will you just revert back to feeling crap if you stop taking it?

Any other side effects beside water retention?

I wouldn't recommend going on piog if you're not comfortable with taking another drug with potential risks. The only side effect so far is fluctuating weight, but i am a bit underweight so i don't mind it. Other risks are congestive heart failure (because of fluid retention) and bladder cancer if you take it longer than a year.

I don't plan to use it forever. Theoretically, at some point all inflammation and iron overload should be reversed. At that point, my tissues will no longer be insulin resistant so aldh1a3 levels will be normal again. At that point i can stop taking it.

There are people with scarring alopecia who took this drug and stabilised. After stopping, they had remission so i believe this drug can help me long term, but i still don't know how long exactly i will take it. I also have a brain mri every 6 months so i hope these lesions will fade but i'm realistic that it might not be reversible.

It seems like it's a relatively safe and effective drug but i don't want to encourage anyone here taking it because there are still some risks. Anyway, i feel like i'm improving so i'm hopefull.

31 minutes ago, Lifesuckshard said:

I wouldn't recommend going on piog if you're not comfortable with taking another drug with potential risks. The only side effect so far is fluctuating weight, but i am a bit underweight so i don't mind it. Other risks are congestive heart failure (because of fluid retention) and bladder cancer if you take it longer than a year.

I don't plan to use it forever. Theoretically, at some point all inflammation and iron overload should be reversed. At that point, my tissues will no longer be insulin resistant so aldh1a3 levels will be normal again. At that point i can stop taking it.

There are people with scarring alopecia who took this drug and stabilised. After stopping, they had remission so i believe this drug can help me long term, but i still don't know how long exactly i will take it. I also have a brain mri every 6 months so i hope these lesions will fade but i'm realistic that it might not be reversible.

It seems like it's a relatively safe and effective drug but i don't want to encourage anyone here taking it because there are still some risks. Anyway, i feel like i'm improving so i'm hopefull.

just to be clear and apologies if Ive asked you before but you have had blood tests correct that show clearly aniron overload??

Again, your reason to go on pioglitazone youve weighed up yeah, the iron overload and the brain lesions

These issuescould be unique to you though so I wouldnt go on it unless I really have to. None the less Iappreciate your feedback and want to wish you well with it

The insulin/inflammation issue is interesting, many have reported ithere so perhaps youre on to something that more of us need to follow.

5 hours ago, TrueJustice said:

just to be clear and apologies if Ive asked you before but you have had blood tests correct that show clearly aniron overload??

Again, your reason to go on pioglitazone youve weighed up yeah, the iron overload and the brain lesions

These issuescould be unique to you though so I wouldnt go on it unless I really have to. None the less Iappreciate your feedback and want to wish you well with it

The insulin/inflammation issue is interesting, many have reported ithere so perhaps youre on to something that more of us need to follow.

I had blood tests showing high blood glucose and high neutrophil count and low lymphocyte count (this indicates inflammation). I didn't test iron, but it wouldn't show in a blood test anyway. The problem accutane caused is mitochondrial iron overload, this won't show on blood tests. And iron overload which causes demyelination is the only thing that can explain my brain lesions. My thyroid came out fine, although i have my doubts about the accuracy of this test. I had hypothyroid signs like thinning eyebrows.

Maybe these issues are unique to me, although i think probably many people who have post accutane problems have developed some degree of inflammation and insulin resistance in their tissues. It's mostly adipose (fat tissue) that's the problem, but it can also explain why it's harder get muscles for example. And about the liver, i highly doubt accutane could have done permanent damage. In the worst case, accutane could have caused fatty liver (which further worsens insulin resistance), which can be reversed (also with piog).

1 hour ago, Lifesuckshard said:

I had blood tests showing high blood glucose and high neutrophil count and low lymphocyte count (this indicates inflammation). I didn't test iron, but it wouldn't show in a blood test anyway. The problem accutane caused is mitochondrial iron overload, this won't show on blood tests. And iron overload which causes demyelination is the only thing that can explain my brain lesions. My thyroid came out fine, although i have my doubts about the accuracy of this test. I had hypothyroid signs like thinning eyebrows.

Maybe these issues are unique to me, although i think probably many people who have post accutane problems have developed some degree of inflammation and insulin resistance in their tissues. It's mostly adipose (fat tissue) that's the problem, but it can also explain why it's harder get muscles for example. And about the liver, i highly doubt accutane could have done permanent damage. In the worst case, accutane could have caused fatty liver (which further worsens insulin resistance), which can be reversed (also with piog).

 

I know someone with lesions it can be somehow related to migraine, I was told anyway, not sure of the exact details.

Have you talked to a doc about piog, sounds too risky for me.

So accutane can absolutely cause permanent damage to the mitochondria, but there's no possible way for it to permanently damage the liver, which contains mitochondria.That does not compute.

The mainstream treatment for hypervitaminosis A is phosphatidylcholine. Wikipedia mentions this. Accutane is close to vitamin A, and alpha GPC is close to phosphatydilcholine. Choline has also been shown to help with nerve myelin tissue repair.

More common side effects of pioglitazone include

Chest pain

decreased urine output

dilated neck veins

extreme fatigue

irregular breathing

irregular heartbeat

problems with teeth

swelling of the face, fingers, feet, or lower legs

tightness in the chest

trouble breathing

weight gain

Less common

Pain or swelling in the arms or legs without an injury

pale skin

swelling

trouble with breathing when active

unusual bleeding or bruising

unusual tiredness or weakness

not saying I've found the cure by any means, but will stick with it and report results later.

31 minutes ago, Aaron76 said:

So accutane can absolutely cause permanent damage to the mitochondria, but there's no possible way for it to permanently damage the liver, which contains mitochondria.That does not compute.

The mainstream treatment for hypervitaminosis A is phosphatidylcholine. Wikipedia mentions this. Accutane is close to vitamin A, and alpha GPC is close to phosphatydilcholine. Choline has also been shown to help with nerve myelin tissue repair.

More common side effects of pioglitazone include

Chest pain

decreased urine output

dilated neck veins

extreme fatigue

irregular breathing

irregular heartbeat

problems with teeth

swelling of the face, fingers, feet, or lower legs

tightness in the chest

trouble breathing

weight gain

Less common

Pain or swelling in the arms or legs without an injury

pale skin

swelling

trouble with breathing when active

unusual bleeding or bruising

unusual tiredness or weakness

not saying I've found the cure by any means, but will stick with it and report results later.

 

 

 

 

Sorry, i just thaught the liver is able to repair itself even when it's really damaged. I'm not that educated on biology. So you will try phosphatidylcholine? Does this mean hypervitaminosis A and not vitamin A deficiency is the problem? Because i feel like one of the biggest problems is how the body handles retinol. So our retinol metabolism is out of whack. And i thaught we're deficient in real vitamin A, which causes thyroid problems and energy expenditure problems

I have tried phosphatidylcholine aka lecithin and it is no good for several reasons. 1, it's rich in inositol, which is anti androgenic. 2, it's rich in phosphorous and low in calcium, which harms the bones. 3, it's rich in pufa, which is anti androgenic and harms the liver.

I believe alpha GPC is a much healthier approach. It's rich in choline and lower in the above three harmful agents. Alpha GPC can still boost Lrat, which I think is huge for accutane ppl.

You are correct that one of our biggest issues is how the body handles retinol. We are deficient in true retinol and overloaded with it's metabolite, retinoic acid. The excess retinoic acid impairs true retinol absorption and metabolism. Remove the excess retinoic acid and true retinol absorption and metabolism is restored.

I believe calcium citrate and alpha GPC, along with vitamin c gummies and Dijon mustard are key to fix this. Mustard is a fiber free brassica, which are rich in glucosinolates, which are key for cytochrome p450 and glucuronidation, which metabolize accutane. Calcium citrate helps push accutane out of the bones and into circulation. Vitamin c gummies helps ensure adequate bile formation and flow. Go with your instincts. If you're in the mood for some vitamin c gummies, take some. If you're in the mood for some Dijon mustard, do it. The alpha GPC is 1.2g/day and calcium citrate is 1g/day.

Take my posts with a grain of salt. Started feeling worse down below, did a biofeedback scan, livers a mess, and machine recomended l arginine. Just took some arginine. Will see how it goes.

I know it sounds crazy that a drug from 30 years ago could still be there, but to me that's how it seems. It feels like I've been shifting it around different parts of my body. I have such strong, pronounced reactions to supplements that is not at all normal. Will do more biofeedback later and report if anything interesting.

6 minutes ago, Aaron76 said:

Take my posts with a grain of salt. Started feeling worse down below, did a biofeedback scan, livers a mess, and machine recomended l arginine. Just took some arginine. Will see how it goes.

I know it sounds crazy that a drug from 30 years ago could still be there, but to me that's how it seems. It feels like I've been shifting it around different parts of my body. I have such strong, pronounced reactions to supplements that is not at all normal. Will do more biofeedback later and report if anything interesting.

It certainly is a viscous cycle. My last few kinesiology visits, the practitioner has said the feedback my body gives is liver talk to the large intestine so we follow this, the next week the large intestine says talk to the liver, its just goes back & forth

The point is, you work on one organ and it just moves it to another. Dont forget the lymphatic either, Im still shifting waste thru this system, particularly around liver and this week prostate area

My belief is you cant just supplement, the kinesiology corrections must be done too for full effect. Also the practitioner can test the supplement you bring in, whilst the product itself might be good i.e the ingredient,weve noticed sometimes the pill casing itself my body doesnt like, for this reason we mostly supplement with tinctures and drops

Anyway each to their own I guess

.

.

On 7/31/2021 at 9:58 PM, george20 said:

Hey Mabbbs, I looked at your comment history and saw that you have a food intolerance byaccutane.

Apart from that, what else do you have? If it is not much trouble to ask you, any pain? vomiting, reflux? something like that like abdominal pain, constipation or diarrhea?
I would be interested to know what your gastrointestinal symptoms are, because all those who get these problems have intolerances, bloating or pain.

 

Heyy!! Sorry for the late reply. Post-accutane, I had severe food intolerances. This is one of my major symptoms, but its actually the only symptom that I was able to treat (took me one year of strict work to finally say I no longer havefood intolerances). I still have some bloating and pain thats not related to food.Im extremely grateful for no longer having to suffer from thissince it was very severe (Id eat a bite and feel very fatigued and have to sleep after eating breakfast or feel low the entire day and cant focus). Im sure this is from accutane, since I developed this right after taking accutane and lasted for 4 years until I decided to focus on treating it.

On 8/12/2021 at 3:39 AM, Aaron76 said:

I have tried phosphatidylcholine aka lecithin and it is no good for several reasons. 1, it's rich in inositol, which is anti androgenic. 2, it's rich in phosphorous and low in calcium, which harms the bones. 3, it's rich in pufa, which is anti androgenic and harms the liver.

I believe alpha GPC is a much healthier approach. It's rich in choline and lower in the above three harmful agents. Alpha GPC can still boost Lrat, which I think is huge for accutane ppl.

You are correct that one of our biggest issues is how the body handles retinol. We are deficient in true retinol and overloaded with it's metabolite, retinoic acid. The excess retinoic acid impairs true retinol absorption and metabolism. Remove the excess retinoic acid and true retinol absorption and metabolism is restored.

I believe calcium citrate and alpha GPC, along with vitamin c gummies and Dijon mustard are key to fix this. Mustard is a fiber free brassica, which are rich in glucosinolates, which are key for cytochrome p450 and glucuronidation, which metabolize accutane. Calcium citrate helps push accutane out of the bones and into circulation. Vitamin c gummies helps ensure adequate bile formation and flow. Go with your instincts. If you're in the mood for some vitamin c gummies, take some. If you're in the mood for some Dijon mustard, do it. The alpha GPC is 1.2g/day and calcium citrate is 1g/day.

Obviously no one including myself is an expert, but I really would like proof retonic acid is now high.

Also increasing p450 may lower retinol, right?

On 8/11/2021 at 6:46 PM, Aaron76 said:

Take my posts with a grain of salt. Started feeling worse down below, did a biofeedback scan, livers a mess, and machine recomended l arginine. Just took some arginine. Will see how it goes.

I know it sounds crazy that a drug from 30 years ago could still be there, but to me that's how it seems. It feels like I've been shifting it around different parts of my body. I have such strong, pronounced reactions to supplements that is not at all normal. Will do more biofeedback later and report if anything interesting.

It is interesting, my question is how this is even in the liver or perhaps in the body, a substance in large or small quantities must one day be expelled by the body and if it is still I wonder why people have non-fatal damage, if a Substance is in the body for a long time or 3 decades you may be dead, even so if this drug is synthetic trying to trick the body, maybe we ingest something synthetic so the body reacted badly to a substance that is not 100% natural and I activate a defense method, but I don't think so since this would happen like the other drugs, although it does, but in large doses.
An important point that I have been able to collect through "studies" is that this drug damages cells, but they have the ability to return to how they were before, on the other hand, it affects brain cells which are responsible for various chemical processes which contributes to the depression or various sexual factors, by this method, also affects the entire gastric epithelium.
My question is: where do you think the substance is housed? In body fat, liver?
Or maybe this substance damages genes totally suppressive to the damage of this substance, therefore it damages some and most does not.

Don't know if any of you could help me with my skin condition on face. After last dose of accutane 4 years ago, my skin scar so easily till TODAY.I know skin scar easily while on accutane and post 6months. But its been 4years for me.

I cannot do any scar treatments and exfoliating products as it will caused new indent scars, is like getting new scars from nothing, or from merely light scratching or merely peeling fromdry patch on the face. Its been like this till today.

I cannot use any product on face. Any product on face caused breakout of pimples/acne, even simple product with just 1 ingredient list, example just beta glucan or hyaluronic acid no other ingredient.

Is like i cannot let anything touched my face, else itscar or breakout.

And it seems like most people with skin problems after accutane are mainly redness, dryness, no oil production.

I have all of these, but with the easy scaring problems for years?!
Does any of you have same exact problem as me?

6 hours ago, jellyy said:

Don't know if any of you could help me with my skin condition on face. After last dose of accutane 4 years ago, my skin scar so easily till TODAY.I know skin scar easily while on accutane and post 6months. But its been 4years for me.

I cannot do any scar treatments and exfoliating products as it will caused new indent scars, is like getting new scars from nothing, or from merely light scratching or merely peeling fromdry patch on the face. Its been like this till today.

I cannot use any product on face. Any product on face caused breakout of pimples/acne, even simple product with just 1 ingredient list, example just beta glucan or hyaluronic acid no other ingredient.

Is like i cannot let anything touched my face, else itscar or breakout.

And it seems like most people with skin problems after accutane are mainly redness, dryness, no oil production.

I have all of these, but with the easy scaring problems for years?!
Does any of you have same exact problem as me?

This drug changes the entire microbiome of your skin, some believe that after treatment your skin cannot absorb the vitamin D that comes from the sun in a good way due to the change it produces and the stem cells it kills.
I'm not surprised by the skin damage this substance causes.

Hi

I wanted to ask - if anyone can give some feedback it would be great. I was on roaccutane 2 times (both times for 9-11 months) when I was 16 and 18 years old. I developed terrible overactive bladder problems since the second time and have had to deal with bad frequent urination/nocturia problems for last 15 years along with digestive problems and more. Has anyone here had overactive bladder problems after being on this drug. I'm sure its done a lot more to me but I am trying to connect the dots slowly.

On 8/13/2021 at 1:24 AM, Calcified said:

Obviously no one including myself is an expert, but I really would like proof retonic acid is now high.

Also increasing p450 may lower retinol, right?

Increasing cytochrome p450 would increase the clearance of retinoids, caffeine, toxins, etc. Dijon mustard is great for speeding cytochrome p450 since it's rich in glucosinolates.

On 8/15/2021 at 3:43 PM, george20 said:

It is interesting, my question is how this is even in the liver or perhaps in the body, a substance in large or small quantities must one day be expelled by the body and if it is still I wonder why people have non-fatal damage, if a Substance is in the body for a long time or 3 decades you may be dead, even so if this drug is synthetic trying to trick the body, maybe we ingest something synthetic so the body reacted badly to a substance that is not 100% natural and I activate a defense method, but I don't think so since this would happen like the other drugs, although it does, but in large doses.
An important point that I have been able to collect through "studies" is that this drug damages cells, but they have the ability to return to how they were before, on the other hand, it affects brain cells which are responsible for various chemical processes which contributes to the depression or various sexual factors, by this method, also affects the entire gastric epithelium.
My question is: where do you think the substance is housed? In body fat, liver?
Or maybe this substance damages genes totally suppressive to the damage of this substance, therefore it damages some and most does not.

I believe accutane is a radioactive poison that is stored in body fat. As you all know, radioactive materials have extremely long half lives, which explains how it could be trapped in the body for life.

What makes something radioactive? It's polarity. Natural retinoic acid contains an even mix of trans and cis isomers, which prevents it from being polarized, or radioactive. But what happens when you remove the trans isomers, the smaller cis isomers, and have only 13 cis retinoic acid remaining? You get something that is highly polarized, which makes it radioactive.

My biofeedback machine has always recommended laminaria as the top food recommendation from day one. I never even knew what that was at first. It's also known as kelp, so I tried some garbage kelp supplements that were no good. Later tried modifilan which wasn't much better. Tried some bladderwrack. No luck. Then I found a product known as biofilam on amazon. Wow. Not healed by any means but it has a healing action on my brain like nothing else ever has. Ginkgo doesn't even come close to biofilam as far as positive brain effects.

Biofilam is what Russian scientists came up with back in the late 80s to detoxify Russian citizens after Chernobyl.

When I use biofilam, and I do body scans with the biofeedback machine later in the day, the machine says it detects radiation in my liver and my gut. This tells me the biofilam is flushing radioactive accutane from the cell nucleus and into circulation for removal. biofilam is rich in alginic acid, which science has shown binds to radioactive material and removes it from the body.

Usually my stools are light brown or pale colored. After starting biofilam, the stool is a darker brown color. Will biofilam heal me completely from accutane? I have no idea. Will I stick with it daily in the hopes that it will? Absolutely. Right now I'm doing 3 capsules in the am and 3 capsules in the pm.

I think you can buy laminaria powder from bulk supplements website, considerably cheaper than biofilam, and the quality seems to be just as good based on user reviews. If you don't like the taste you can make your own capsules. Will keep the board posted.