For me personally (regarding iron), I have alwayshad low ferritin in my blood tests instead.

Something that might be of interest to you all, some time back, I suspected celiac because of my gluten sensitivity that I seemed to developafter taking Accutane. My gluten intolerance/ celiac test returned to be normal (negative), but after going to multiple doctors, one of them ordered for me the HLA-DQ8 and HLA-DQ2 genes test. Those are known as the "celiac genes," but they are not necessarily only for celiac.My DQ2 returned negative but my DQ8 returned positive. He said that I still don't have celiac, but after looking into it, since the gene is also responsible for other autoimmune conditions, I wouldn't be surprised if Accutane is the cause for this positive result. I also happen to not have any diagnosed autoimmune conditiondespite symptoms (like arthritis, but my blood tests are normal). Did any of you have this gene tested?

Turmeric can fight apoptosis, I had heard that both ginger and turmeric are superfoods with great healing powers.

https://thetruthaboutcancer.com/chemotherapy-detox/

Hello everyone!

I'm unfortunately new to this. Took accutane for ten month and by the last month developed dry eyes/MCGD... I also have hair shading but it doesn't bother me as much as my eyes

Any advice on what to do? Detox/supplements? I can't read the whole thread unfortunately, I can't really read at all now... I'm really desperate!

@Lifesuckshardwill this this help with meibomian gland dysfunction what do you think?

7 hours ago, Valeriia said:

Hello everyone!

I'm unfortunately new to this. Took accutane for ten month and by the last month developed dry eyes/MCGD... I also have hair shading but it doesn't bother me as much as my eyes

Any advice on what to do? Detox/supplements? I can't read the whole thread unfortunately, I can't really read at all now... I'm really desperate!

@Lifesuckshardwill this this help with meibomian gland dysfunction what do you think?

 

Hello, welcome!

How long has your eye been dry?
Clearly this is a side effect that is difficult to solve if not impossible, once accutane diminishes itthere are not many chances to bring it back to normal.
But if you are with this for a short time, you can wait for time to return as before.

well, there are hundreds of testimonials from people who have returned to normal after strong and long-term adverse effects

Many tend to investigate a lot and get closer to what is the function of 13-retinoic acid in the body so that you can understand what it was that you actually administered through your mouthand maybe find a solution.

I had read in another forum a man who had the problem of dry eye since he was born, he basically said that when he drank too much and too much water his eye was more lubricated.
Clearly I don't know if it must be the same type of severity of dry eyes, but I read about it.

Has anyone tried milk thistle? clearly according to me this substance is no longer in the body, but I want to try detoxification and an intestinal and digestive cleansing, I do not suffer or anything but my habits are different and that has kept me a bit worried.
But with this addictive crap of carbohydrates, lactose, fructose and gluten my system will never find balance. It's really hard to get food out of the diet, even though I've always suffered from intestinal disorders hahaha.

I can hold on to the side of being a paleo diet and not vegan, the paleo diet has been shown to be able to remit "paleo autoimmune" autoimmune problems and maintain the necessary balance of nutrients and vitamins.
During this forum I have never asked if someone suffered from intestinal or habit disorders, if you suffered from this, you could indicate your symptoms or something, thank you!

On the other hand, according to Tom's story, there is a video in which he shows that accutane remains in the liver even and that the bile is affected and this means that the retinoicacid is not expelled through the bile, it is supplemented with bile of ox to allow the flow of bile.
Something completely contraindicatory since if your shit comes out brown or light brown, your bile flow is fine, for that shit it is supplemented with olive oil and lemon.

If this substance does not come out through the bile, it comes out through the urine.

Has anyone realized that the problems that all or most of the problems that you claim to have are autoimmune problems?

On 7/25/2021 at 8:56 PM, Lifesuckshard said:

I think there are multiple reasons our hair is suffering. First of all, it's drier because there is less sebum. But this isn't the biggest problem. Thereare many people with dry skin/hair while it's still healthy.

Just like our skin, the hair shaft can't hold water anymore post accutane, and this causes the textural problems (brittle, breakage, kinking). Ppar y activation should improve water retention in the skin and hair shaft.

The increased shedding and loss of density is because ATRA affects the hair cycle. ALDH1a3 is found in hair follicles and if insulin resistance caused aldh1a3 to be permanently upregulated, you'll suffer chronic telogen effluvium (it's actually premature catagen in our case).

Iron overload also causes hairloss and autoimmune reactions (ATRA is immuno-modulating) are probably also a factor. Ppar y activation takes care of all these problems (theoretically).

Maybe dopamine also affects hair,but these dopamine problems are just the result of iron accumulation.

https://diabetes.diabetesjournals.org/content/51/8/2348

This is about the relationship between iron, oxidative stress and insulin resistance.

Hows the pioglitazone going after a week?

On 7/27/2021 at 11:19 PM, george20 said:

Has anyone tried milk thistle? clearly according to me this substance is no longer in the body, but I want to try detoxification and an intestinal and digestive cleansing, I do not suffer or anything but my habits are different and that has kept me a bit worried.
But with this addictive crap of carbohydrates, lactose, fructose and gluten my system will never find balance. It's really hard to get food out of the diet, even though I've always suffered from intestinal disorders hahaha.

I can hold on to the side of being a paleo diet and not vegan, the paleo diet has been shown to be able to remit "paleo autoimmune" autoimmune problems and maintain the necessary balance of nutrients and vitamins.
During this forum I have never asked if someone suffered from intestinal or habit disorders, if you suffered from this, you could indicate your symptoms or something, thank you!

On the other hand, according to Tom's story, there is a video in which he shows that accutane remains in the liver even and that the bile is affected and this means that the retinoicacid is not expelled through the bile, it is supplemented with bile of ox to allow the flow of bile.
Something completely contraindicatory since if your shit comes out brown or light brown, your bile flow is fine, for that shit it is supplemented with olive oil and lemon.

If this substance does not come out through the bile, it comes out through the urine.

Has anyone realized that the problems that all or most of the problems that you claim to have are autoimmune problems?

 

Ive tried milk thistle, and plan on drinking it consistently staring this week. Whenever I drink it, I feel a bit sleepy. Will updateif I notice anything dramatic.

14 hours ago, TrueJustice said:

Hows the pioglitazone going after a week?

My sleep improved and i feel better waking up (always felt like shit when waking up since accutane). Eating actually gives me energy instead of making me feel tired. These are things i already notice after a week.

My skin also looksgood, but i don't know if that's because of pioglitazone. It's not oily, but has a nice glow.

Alright, so the critical factor that happens from isotretinoin is leydig cell apoptosis. Apoptosis is the programmed cell death of a Eukaryotic cell. Leydig cells are responsible for testosterone production. Luckily, it doesn't affect too many other types of cells but it is also slightly nuerotoxic meaning there might be a loss of about 1-5 IQ points and a loss of concentration and memory. A scientist recently discovered that Leydig cells can be replicated from certain types of stem cells in the lab however naturallyLeydig cell production pretty much ends at about 60 days after conception in the womb as a fetus. This video that I am sharing estimates that it would be a few years until this is developed into a medical procedure, where Leydig cells could be added to the testis. Notably, water fasting does not actually cause Leydig cell replication since Leydig cell replication stops 7 months before birthso I was wrong about that. Meanwhile, daily injections of HCG, androgel, and a testosterone support supplements are what can be used to stimulate testosterone production naturally for now. Also a 3 day water fast once every month helps keep testosterone and libido about as high as they can be naturally and also might improve cognition and memory back to pre-istotretinoin levels. Finally, isotretinoin is thought to down regulate tellomerase, leading to pre-mature aging. Doing yoga helps release tellomerase naturally so I would also recommend doing yoga for ideally 30 minutes a day 3-7 times per week. Other than that, eating a healthy diet and doing cardiovascular exerciseimprove things on a whole as well. My strong opinion is that Accutane's long lasting side effects are not a result of current toxicity levels so my strong recommendation is to stop worrying so much about detoxing anyways the best way to detox is to do a water fast.

21 minutes ago, DeepAcceptance said:

Alright, so the critical factor that happens from isotretinoin is leydig cell apoptosis. Apoptosis is the programmed cell death of a Eukaryotic cell. Leydig cells are responsible for testosterone production. Luckily, it doesn't affect too many other types of cells but it is also slightly nuerotoxic meaning there might be a loss of about 1-5 IQ points and a loss of concentration and memory. A scientist recently discovered that Leydig cells can be replicated from certain types of stem cells in the lab however naturallyLeydig cell production pretty much ends at about 60 days after conception in the womb as a fetus. This video that I am sharing estimates that it would be a few years until this is developed into a medical procedure, where Leydig cells could be added to the testis. Notably, water fasting does not actually cause Leydig cell replication since Leydig cell replication stops 7 months before birthso I was wrong about that. Meanwhile, daily injections of HCG, androgel, and a testosterone support supplements are what can be used to stimulate testosterone production naturally for now. Also a 3 day water fast once every month helps keep testosterone and libido about as high as they can be naturally and also might improve cognition and memory back to pre-istotretinoin levels. Finally, isotretinoin is thought to down regulate tellomerase, leading to pre-mature aging. Doing yoga helps release tellomerase naturally so I would also recommend doing yoga for ideally 30 minutes a day 3-7 times per week. Other than that, eating a healthy diet and doing cardiovascular exerciseimprove things on a whole as well. My strong opinion is that Accutane's long lasting side effects are not a result of current toxicity levels so my strong recommendation is to stop worrying so much about detoxing anyways the best way to detox is to do a water fast.

 

Joder, que culto.

Thx for this insight DeepAcceptance

Im a bit worried about going on testosterone treatment because I hear you have to be on it for life plus it shrinks your balls. As time goes on though and I still feel down with not enough energy, it may be what I have to turn to

A Russian doctor I see on and off, has this program waiting for me should I go down that path:

testosterone 20% ( gel you rub on balls )

melatonin supplement3mg

DHEA supplement 50mg

pregnenolone 100mg

He is on the testosterone gel himself and said you really go on it for life, you can stop but youll just go back to how youre feeling now.

11 hours ago, TrueJustice said:

Thx for this insight DeepAcceptance

Im a bit worried about going on testosterone treatment because I hear you have to be on it for life plus it shrinks your balls. As time goes on though and I still feel down with not enough energy, it may be what I have to turn to

A Russian doctor I see on and off, has this program waiting for me should I go down that path:

testosterone 20% ( gel you rub on balls )

melatonin supplement3mg

DHEA supplement 50mg

pregnenolone 100mg

 

He is on the testosterone gel himself and said you really go on it for life, you can stop but youll just go back to how youre feeling now.

 

 

You tried Ritalin or Dexamfetamin? Gives alot of energy.

On 7/29/2021 at 7:02 AM, Mabbbs said:

Ive tried milk thistle, and plan on drinking it consistently staring this week. Whenever I drink it, I feel a bit sleepy. Will updateif I notice anything dramatic.

Hey Mabbbs, I looked at your comment history and saw that you have a food intolerance byaccutane.

Apart from that, what else do you have? If it is not much trouble to ask you, any pain? vomiting, reflux? something like that like abdominal pain, constipation or diarrhea?
I would be interested to know what your gastrointestinal symptoms are, because all those who get these problems have intolerances, bloating or pain.

The leydig cells thing sounds really worrying if true. I still haven't tested my T levels, but i never got erectile dysfunction. Isotretinoin caused low energy and made me lethargic and unable to be happy. As a result, my libido also got worse after a while. I can always masturbate if i force myself, but it's just not as pleasurable as before. You know what i mean.

I'm 1,5 week on pioglitazone and all i can say is that my libido is very good right now and i begin to feel a bit better energy wise. But at this point, it might be placebo. I just think the reason many people suffer sexual sides is because of dopaminergic issues. Testosterone is not the biggest factor when it comes to arousal. It's mostly dopamine and neurotransmitters in the brain. Of course testosterone is also important, but i don't think that's the biggest problem here. And i had an mri that showed brain lesions so i know this is atleast for me the case (you can also have dopaminergic problems without having brain lesions).

On 8/1/2021 at 7:51 AM, Lifesuckshard said:

The leydig cells thing sounds really worrying if true. I still haven't tested my T levels, but i never got erectile dysfunction. Isotretinoin caused low energy and made me lethargic and unable to be happy. As a result, my libido also got worse after a while. I can always masturbate if i force myself, but it's just not as pleasurable as before. You know what i mean.

I'm 1,5 week on pioglitazone and all i can say is that my libido is very good right now and i begin to feel a bit better energy wise. But at this point, it might be placebo. I just think the reason many people suffer sexual sides is because of dopaminergic issues. Testosterone is not the biggest factor when it comes to arousal. It's mostly dopamine and neurotransmitters in the brain. Of course testosterone is also important, but i don't think that's the biggest problem here. And i had an mri that showed brain lesions so i know this is atleast for me the case (you can also have dopaminergic problems without having brain lesions).

It cant be said thatLeydig cell apoptosis is the only thing that goes wrong.

Females can and are adversely affected post tane which is probably more dopamine related if I had to guess

It would be good to know if you can still have no erectile or testosterone issues yet still have leydig cell issues??Ive had testosterone checks over the years and have only now run into issues in my 40s, prior to this I never had an issue other than my fatigue which could be any number of things.

Testosterone issuescan happen anyway at my age so hard to know if my current issues are just from age or are linked to tane

At least the leydig info is another thing to look at, Im grateful it got posted hereotherwise youd never even know about it

12 hours ago, TrueJustice said:

It cant be said thatLeydig cell apoptosis is the only thing that goes wrong.

Females can and are adversely affected post tane which is probably more dopamine related if I had to guess

It would be good to know if you can still have no erectile or testosterone issues yet still have leydig cell issues??Ive had testosterone checks over the years and have only now run into issues in my 40s, prior to this I never had an issue other than my fatigue which could be any number of things.

Testosterone issuescan happen anyway at my age so hard to know if my current issues are just from age or are linked to tane

At least the leydig info is another thing to look at, Im grateful it got posted hereotherwise youd never even know about it

Yeah it's interesting information about the leydig cells. I actually didn't know these cells were responsible for testosterone production. I just hope isotretinoin didn't actually make some of these cells die because this would be very hard to reverse it seems.

If women also experience sexual side effects then it's probably more of a dopaminergic issue. In fact, dopamine and neurotransmitters seems to be the most important factor when it comes to libido. Without dopamine, it will be hard to feel happy and aroused.

I think the one gal was right, talking about the importance of the liver a while back. Lrat I believe is huge. Alpha GPC feeds Lrat. Below is my current program. Will see how it goes over the coming weeks. Godspeed.

Daily supplements
Alpha GPC, unlimited
Vitamin c gummies, as desired

Diet
Omnivore
Organic when possible

Avoid
Soy
Pork
Gmo
Alcohol
Caffeine
Tobacco
Cannabis
Artificial sweeteners
Artificial preservatives

My biofeedback machine has never indicated any testicular or leydig cell issues. It has always indicated liver/cholestasis/gallbladder issues.

I believe once the liver issue is restored all things accutane including hair issues are restored. The liver is the quarterback of the body, distributing nutrition to all parts of the body. I'm not a big fan of turmeric because of its anti androgen properties.

The problem with milk thistle is that it's estrogenic, and we already have issues with estrogen metabolism. The problem with ox bile is that it shuts down 5 alpha reductase, which lowers our dht. Not a good thing. You want to be creating and using your body's own bile. I believe accutane is expelled from the body from both ends, front and back, ie stool and urine both.

I respect everyone's theories since we have things in common, we all seek recovery, but we must be honest ... accutane is no longer in the body, it foams up and what we administer synthetically does not exist, let's take healing as harm already done and we must reverse it. It surprises me that the liver does not have the capacity to restore since it is capable of regenerating if a piece is cut off and it is not able to recover from an ingested substance. A more in-depth study should be done as to why some and a small minority are damaged and the others are healthy and fresh like lettuce.

How can bile be reversed? Is it possible for the bile to flow again like before?

I'm open to both theories, it's still there vs it's permanent damage. If its permanent damage, then maybe increasing methyl donors might be key. Choline is a methyl donor, and alpha GPC is probably the best choline supplement out there. Vitamin c is important for bile flow also. Will report good or bad in the coming weeks.

Would it be wrong to say, increase testosterone and insulin issues would be fixed, fatty liver would improve, fatigue and depression would improve, oil would return back to the body?

Now how you go about increasing testosterone is the question, trying to do naturally seems to have limited results

Have tolook at other options, gels and/or injections etc

Tj it would be totally wrong to say that. Lol jk! That is possible. What's the precursor to testosterone? Cholesterol. What's the precursor to cholesterol? Saturated fat. What ends up in our stools in the toilet? Saturated fat. Why? Because we're not absorbing and utilizing it.

Well what if we start supplementing with alpha GPC and vitamin c gummies, then what? Well, theyd both likely help with bile flow, which would improve fat absorption and utilization. Will keep the board posted.

interestingly, vitamin C also plays an important role in cellular oxidation, on the other hand, in my case my skin is oilier than a jar of peanut butter, so I close the theory that accutane remains in the body because sebocytes they die and do not release fat.

5 hours ago, george20 said:

interestingly, vitamin C also plays an important role in cellular oxidation, on the other hand, in my case my skin is oilier than a jar of peanut butter, so I close the theory that accutane remains in the body because sebocytes they die and do not release fat.

I agree. Im more inclined to ask, what has it altered this drug??

Idput money on that its long gone but that it fucks up things like how our bodies use Vit A years later

Ive long given up thinking I need to detox isotretinoin, that doesnt mean though my bodyknowswhat to do with Vit A.personally I think its messed up how I process it and all the complications that come with it

3 hours ago, TrueJustice said:

I agree. Im more inclined to ask, what has it altered this drug??

Idput money on that its long gone but that it fucks up things like how our bodies use Vit A years later

Ive long given up thinking I need to detox isotretinoin, that doesnt mean though my bodyknowswhat to do with Vit A.personally I think its messed up how I process it and all the complications that come with it

Hopefully, studies will look into this area in the future.