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@Aaron76 thanks man. will try the gotu kola first
8 hours ago, Anna Nim said:Is this a spam post?
Guessing I do not care if my son has ACNE, when he has Anxiety, Joint Pain, Erectile Dysfunction, Hair and Sinus and dental issues..but hey, lets so see another dermatologist..
What do you mean by RSO full program?
Are you not able to get surgery for your hital hernia. I had that surgery. It was a cakewalk and FIXED my acid issue.
No, no one has even mentioned that before
please tell me what that involves?
The gastroenterologist said I need to be on pariet for life, my kinesiologist thinks differently!!
Surgery could be a third option too
14 hours ago, Aaron76 said:I've put the cordyceps aside for now and am focusing on gotu kola only. 4 capsules daily. protozoa and roundworm parasites both feed on fungi, which is what cordyceps is. Once gotu kola has optimized bile flow and parasites are gone I will reintroduce cordyceps.
Rick simpson oil is illegal due to the thc content. I don't believe it to be any better than CBD oil, which is legal and readily available. I've done cbd in the past and for me, it cant compare with whole herb gotu kola. It's not even close.
Thc + cbd is an whole different game then cbd alone.
Average RSO content should be around 15% + 15%. The higher the better (no pun intended).
The full 90 day protocol is to do a total of 60grams Of RSO in 90 days. Thats alot and you need to builup your tolerance. You will be high as an kite in the beginning
i have done both (Total of 10 gramsRSO )and from my experience, CBD alone feels like a general inflammtion reducer, good for the brain and body. Youll feel relaxed, a bit clearer thinking.
If i take a rice grain of RSO im out for the next 12 hours, alot of body effects, very positive, but for alot of effects it also feels temporary, so then you need a maintenance dose, which i dislike.
if you can get a hold on CBD, take the highest percentage, there is no way you can overdose. So just take whatever feels comfortable.
im truly convinced that our blood flow is reduced, so for now i stick with Gotu Kola and the ginko etc.
maybe also add some adrenal/kidney/brain glands to help the body.
Yes and the source of the blood flow issue is a mystery
I wouldnt even say a supplement is the answer, more like regular exercise probably
Although in order to have the energy you might need a supplement, and if you dont sleep properly you need this and on & on & on
I mean, do we have thicker blood post tane or are our veins compromised or is it genome damage, I just dont know
I personally dont think its all to do with lymphatic before the thread naturally says to look at that....theres more to it unfortunately
1 hour ago, Doctorcolumbus said:Thc + cbd is an whole different game then cbd alone.
Average RSO content should be around 15% + 15%. The higher the better (no pun intended).
The full 90 day protocol is to do a total of 60grams Of RSO in 90 days. Thats alot and you need to builup your tolerance. You will be high as an kite in the beginningi have done both (Total of 10 gramsRSO )and from my experience, CBD alone feels like a general inflammtion reducer, good for the brain and body. Youll feel relaxed, a bit clearer thinking.
If i take a rice grain of RSO im out for the next 12 hours, alot of body effects, very positive, but for alot of effects it also feels temporary, so then you need a maintenance dose, which i dislike.
if you can get a hold on CBD, take the highest percentage, there is no way you can overdose. So just take whatever feels comfortable.
im truly convinced that our blood flow is reduced, so for now i stick with Gotu Kola and the ginko etc.
maybe also add some adrenal/kidney/brain glands to help the body.
Thanks man for that info!
I fully agree that blood flow is reduced. My machine lists gotu kola, ginkgo and cordyceps as it's top three supplement recommendations. The problem with ginkgo is it needs to be in powder form as all gingko capsules are manipulated away from the whole herb natural form into a fractionated standardized extract form, which over time does more harm than good. It's possible that permanent brain damage is the issue, which gotu kola is probably the world's best brain restorative herb.
I've tried beef adrenal, kidney, and brain. For me the ancestral brain seemed to stimulate a massive dopamine loss. Ancestral brain includes liver also. Dr rons brain didn't do that. The phosphorous content of brain seems to throw my mineral balance off. Beef adrenal gave me nice sleep but the genital effect from beef adrenal was ridiculously bad. The kidney seems to boost metabolism a bit. The problem with beef kidney is the high selenium and riboflavin content. Selenium and riboflavin are anti androgenic.
Nutritiondata.com is an excellent resource for looking up nutritional content of foods, and it includes all kinds of beef organs. If you look at beef liver, it's got everything we want, except for the problematic retinol content. Copper, b12, folate, iron. It's fairly low in Selenium and zinc compared with copper, which seems to be the ratio our bodies need.
I've disagreed with undertow about whole food beta Carotene intake, but the guy is absolutely correct about there being an issue with b1, B2, b12, and molybdenum. My machine consistently confirms this. It doesn't recommend supplementing with these things but it recognizes there is an issue. My hope is that the drug is trapped in the skin and lymph, and consistent daily gotu kola use over time will flush it out, and indirectly eliminate the b vitamin and molybdenum issues. The machine is constantly recommending foods like pumpkin and apricots, both rich in carotenoids. Possibly because the drug is still there, and it's trying to counter balance the retinoic acid with natural carotenoids.
This thread value went downhill since like two years. From some serious theories of liver damage and real supplements like TUDCA/Taurine/PUFA's to snake oil and "ginko" Reading some of these posts is like reading some kind of delusional people exhausting the remaining options for the cure. You seem to feed your hopes with some placebo shit hoping that it might help you. And after like 5 years of studying the effects of this drug I'm gonna tell you that the answers to the cure are already in this topic.
Another thing I'm gonna tell you is that none of this ginko/onions/garlics/snake oils isn't going to help you. The mechanisms of this drug is really serious, and superficial things like 1g of garlic per day isn't going to alter the already altered gene expression this drug causes.
You want to cure some of the damage this drug caused?Fix your liver and fix your intestines. But how? The problem is - it depends from person to person. There is no fixed diet, or fixed supplement dosage that will help you. The most important things were actually covered in the Nature's crazy video. In most of the cases, fixing the bile flow also fixes SIBO/Intestines. Why? It's not the drug that affects us, it's the negative feedback loop of many mechanisms in the liver. That's why it's that hard to cure the side effects, because you have tosimultaneously work on certain mechanisms with god knows what dosages of supplements, that affect those mechanisms. The most basic, understable theory I can provideis that the drug downregulates gene expression of lipids metabolism in the liver. This causes a cascade of problems, which amplify the previous problems that the drug has already made (again, the most basic examples are: overloded liver > poor bile production > poor "bad" metabolites excretion > more liver overload > fatmalabsorpotion> PUFA's deficiency > further decline of bile quality and bile flow > altered gene expression beacuse of PUFA deficiency > more liver overload >endoplasmic reticulum stress > chronic fatigueand the mechanisms fuels itself so on and so on.
So you might, or might not understand how hard is to cure all the damage this drug caused. And it's basically a gene lottery and luck, certain people might respond to certain treatments, while others do not.
So based on all of my researches, the only few supplements that might be worth your time are:
EFA (EPA+DHA) in possibly 60% 40% ratio, minimum 5 months of supplementing with 1800mg EPA and 450 DHA based on ( https://www.ncbi.nlm.nih.gov/pubmed/24252845 )
TUDCA (there was a post that mention Nature's Crazy founder that took about 750mg per month, reducing the doseto500mg)
Methionine, Inositol Choline stack (1500mg, 3000mg, 3000mg)
possibly resrevatol to aidUGT2B7 enzyme (neccesary in retinoic acidglucuronidation)
Maybe Lipase if you have pancreatic defficency that further lowers the fat absorption.
Again, the most BASIC theory I can provide, to fix certain, or all of the issues (depending on person)from my head is : problem with fixing your bile is that, the essential fatty acids and others fats needbileto absorb them. You need proper fat absorption, to absorb the fat solutable vitamins (ADEK)by supplementing TUDCA which helps to produce bile, you are absorbing the essential fatty acids which are needed for bile production, liver and gut health (part of the cascade of problems i mentioned).
The issue is, it's much more complicated. There are close to none legit studies, close to 0 people that work on this problem on a serious level, and so on. The theories I provided above are all written from my head on a first try, so if you want details on certain mechanism, you can ask
7 hours ago, TrueJustice said:Yes and the source of the blood flow issue is a mystery
I wouldnt even say a supplement is the answer, more like regular exercise probably
Although in order to have the energy you might need a supplement, and if you dont sleep properly you need this and on & on & on
I mean, do we have thicker blood post tane or are our veins compromised or is it genome damage, I just dont know
I personally dont think its all to do with lymphatic before the thread naturally says to look at that....theres more to it unfortunately
Have you had testosterone tested? There seems to be a sub optimal testosterone level after accutane treatment, also Aaron76 has touched on cell death, Anna Nim questioned growth hormone issues, under_tow mentioned low testosterone after treatment. I think I read a study discussing sub optimal testosterone in elderly causing cell death in joints etc. Testosterone seems to also effect blood flow.
8 hours ago, TrueJustice said:Yes and the source of the blood flow issue is a mystery
I wouldnt even say a supplement is the answer, more like regular exercise probably
Although in order to have the energy you might need a supplement, and if you dont sleep properly you need this and on & on & on
I mean, do we have thicker blood post tane or are our veins compromised or is it genome damage, I just dont know
I personally dont think its all to do with lymphatic before the thread naturally says to look at that....theres more to it unfortunately
Have you had testosterone tested? There seems to be a sub optimal testosterone level after accutane treatment, also Aaron76 has touched on cell death, Anna Nim questioned growth hormone issues, under_tow mentioned low testosterone after treatment. I think I read a study discussing sub optimal testosterone in elderly causing cell death in joints etc. Testosterone seems to also effect blood flow.
Kunus999 did you manage to increase fat soluble vitamins with tudca?
This thread hasn't gone down hill at all. When has there ever been any definitive answers? Never.
Efa is isolated polyunsaturated fat, which wipes out testosterone and induces oxidative stress. Tudca, which includes taurine, wipes out the bodys crucial cholesterol levels. Cholesterol is a precursor to bile, hormones, neurotransmitters, etc. Methionine increases homocysteine. Inositol lowers testosterone. Choline creates fatty acid deficiencies and creates fat cravings. Resveratrol is anti androgenic. All these isolates have been tried and or researched. Synthetic Isolates can't solve the problem.
I'm not saying gotu kola is the cure, but it's the very best thing I've ever taken for brain health, and I've tried tons of things. Google search gotu kola bile duct. Quite interesting. My skin is noticeably softer and smoother after a while of taking it. Sleep is definitely improved. Fat cravings have reduced as well. Don't know if it will heal me completely but it's the very best supplement I've ever taken. I have no reason to lie about this.
If you can provide the studies about the things you mentioned Aaron, it would be helpful. I've never seen (in like 4 or 5 years) a forum dedicated to people that have "wiped out the bodys crucial cholesterol levels" because of TUDCAor a forum with topics like "help me, i've been consuming a lot of fish and I have erectile dysfunction/wiped out testosterone!" which is basically what you stated by ""Efa is isolated polyunsaturatedfat, which wipes out testosterone".
Provide the studies that mention the things you are talking about, preferably on pubmed(do not have to be full text, I use "Sci-hub" to bypass paywalls/restrictions)
It's very simple. Google search taurine lowers cholesterol. Boom, there it is. Googles search saturated fat boosts testosterone. Google search polyunsaturated fat lowers testosterone. Google search polyunsaturated fat, oxidative stress. I'm not going to do it for you. Do it yourself.
People who want omega 3 should eat whole fish, not take toxic polyunsaturated fatty acid supplements. You are clueless if you don't know the difference between whole fish and fish oil. One is healthy. The other is toxic.
Why do you think vegetable oil is so unhealthy. Anyone knows this. It's the polyunsaturated fat. Anyone with a clue about cooking oil knows that evoo is the healthiest cooking oil out there. Why? Because it's Not loaded with toxic pufa. It's loaded with healthier mufa.
Beside supplements, I should've mentioned that the first step to fix something in your life is letting go of ignorance. Go ahead and tell some doctors that problems with fat malabsorpotion can lead to erectile disfunction. Or go ahead and tell a dermatologist that is prescribing you accutane, that this drug oveloads liver, overloads CYP450, upregulates and downregulates crucial genes. Nobody will listen, because the problem with this drug is that it's effect are beyond of understanding of single human. In order to get a real "cure" or some kind of "certifed" treatment regimene, you would have to hire a team ofhepatologists, hematologists, gastrologists, and possibly a hundred of other doctors. Listen, they don't even know exactly how the drug works, due to limited case studies. And here you are, calling me clueless with yourgiberrish about PUFA's wiping testosterone. It's like I'm trying to explain you how wormholes work and you are shouting about earth being flat.
also
First google link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613343/
I spent 10 minutes and I couldn't find the negative correlation with EHA EPA supplementing being associated with testosterone "wiping", it's like I honestly understand what you are typing
Please, just eat or ginko and garlic, if it does help you, I am honestly happy for you. But don't waste my time trying to explain you things that you, yourself do not even understand. Oh and also if all of the things are "very simple" please, share with us your theory about the mechanisms of the drug.
Maybe I'm narrow minded and I skipped something important. It would be also much preffered if you can provide studies to your theories so I can verify them. I am really intrested in the things you mentioned, especially Omega-family fats reducing testosterone and their impact on oxidative stress. Since the community working on this drug is very small "do it yourself" isn't really helping me. I "did it myself" with really a lot of stuff, mostly clinical studiesassociated with Isotretinoin, but like I mentioned in the first part of this post, it's close to impossible that a single person can process so much information alone.
https://www.healthline.com/nutrition/foods-that-lower-testosterone
ALL pufa lacks hydrogen. Doesn't matter if it's omega 3 or 6. None of it contains hydrogen. Hydrogen is what gives saturated fat its testosterone boosting properties. Hydrogen also reduces oxidative stress. Consuming a fat that lacks hydrogen induces oxidative stress. It's very simple.
Yes, the problems that accutane causes are beyond the knowledge of any single human. So why would you want to try getting the answer from a human? Why not utilize the power of quantum biophysics? Which is exactly what I'm doing. These machines can compute things that humans can't. I didn't just pull gotu kola out of my ass. I zeroed in on the cpu of the human brain...the pituitary and hypothalamus, with a highly sophisticated machine that utilizes the power of quantum biophysics.
Healthline headlines, did you even read some of these studies? Yes, flaxseed might lower testosterone IN OBESE WOMEN WITH PCOS HELPING THEM WITH MENSTRUAL CYCLE
In summary, 8 weeks supplementation with 3gr of omega-3 could reduce serum concentrations of testosterone in overweight and obese PCOS patients. In addition, menstrual cycle becomes more regular in this group of subjects. But it does not change the free androgen index and concentratione of sex hormone binding protein.
So essential fatty acids are not really essential, and thousands of studies are wrong because it's "very simple"? There is no place for such two great minds in this community. I'm glad they have you Aaron, sorry for interrupting. Good luck with the cure! I owe you a bottle of ginko.
In all seriousness now. I work on my own and seems like posting any kind of progress is pointless. The discussion is also a waste of time. But I browse this forum regurally, and I read every single post (even those that state that eating 1g of garlic will cure the side effects). If you will fix whatever serious side effect (dry skin, hair loss, depression, ed, liver/gut problems) let me know. If your bio-feedback machine helps you - let us know. But it seems like being active in this thread is just pointless and it leads to spam and frustration.
Essential fatty acids absolutely are essential, and it's essential that you get them from WHOLE FOODS to avoid damaging your body. If you want to be ignorant, take the fish oil and induce oxidative stress while lowering your testosterone levels. If you want to be healthy, then consume whole salmon, whole tuna, whole shrimp, etc. Very simple.
20 minutes ago, Aaron76 said:Essential fatty acids absolutely are essential, and it's essential that you get them from WHOLE FOODS to avoid damaging your body. If you want to be ignorant, take the fish oil and induce oxidative stress while lowering your testosterone levels. If you want to be healthy, then consume whole salmon, whole tuna, whole shrimp, etc. Very simple.
If you can provide yourself a steady 2k EPA - DHA from whole foods, for 5 months (the approximate time it takes for membrane FA composition to reach a new steady state https://www.ncbi.nlm.nih.gov/pubmed/24252845 and https://www.ncbi.nlm.nih.gov/pubmed/9374124 ) then good luck.
And these studies are on HEALTHY controls, with close to 0 problems with downregulated gene expressions of lipid synthesis genes, SIBO, or bile flow problems.
Look at the uploaded graph and read following studies:
https://www.jlr.org/content/38/9/1709.long
https://www.jlr.org/content/7/1/3.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/8801870
https://www.ncbi.nlm.nih.gov/pubmed/18541601
https://www.ncbi.nlm.nih.gov/pubmed/3083086
take your time and read it. you can use Sci-Hub (google it) to access full text resources.
I can provide you with plenty of studies if you want. Maybe essential fatty acid deficiency isn't the major thing, but nobody knows that. All I wanted to share with you, is I THINK, that the most majority of issues comes from negative feedback loop, and this is just a part of it.
Those studies are based on garbage fatty acid isolate supplements that lack synergistic protein, vitamins, and minerals. The reason it took those supplements so long to work is because they did not have the synergistic cofactors found in whole fish. Good luck getting those efa into your cells without the necessary synergistic cofactors.
For me it's easy. I take fish oil I feel tons worse. I eat albacore tuna salad or shrimp and i feel better. Its not rocket science. The core problem is you can't stand the taste of fish, so you try to find a way around it with fish oil, which does you more harm than good.
Try different species. Not all fish tastes the same. For example, I hate salmon, but I love shrimp and tuna. Experiment with different species of seafood until you find a species or two that you enjoy, and go with it.
"so long to work is because they did not have the synergistic cofactors found in whole fish."
what coffactors? Also,can you provide studies made on people that didn't use shitty supplements? Or used "synergistic cofactors"? How does the coffactors alter the absorption?
Also I'm pretty impressed on how you read all of the studies I linked in like 6 minutes
1 hour ago, Kunus999 said:If you can provide the studies about the things you mentioned Aaron, it would be helpful. I've never seen (in like 4 or 5 years) a forum dedicated to people that have "wiped out the bodys crucial cholesterol levels" because of TUDCAor a forum with topics like "help me, i've been consuming a lot of fish and I have erectile dysfunction/wiped out testosterone!" which is basically what you stated by ""Efa is isolated polyunsaturatedfat, which wipes out testosterone".
Provide the studies that mention the things you are talking about, preferably on pubmed(do not have to be full text, I use "Sci-hub" to bypass paywalls/restrictions)
Ive been on these forums for 6-7 years (different account).
first, it is of absolute NO use to say somebody else is going in the wrong direction. I wish we would exploit 100 directions so maybe one of us finds the cure.
So stick to your own theory and keep everybody updated. You say the most widely studies herb ginko is rubbish, RSO is snake oil and you come back with TUDCA and EFA? Already used it.
So please, consider your theory just a different option and the other theory as different options and not a bad theory. We should help eachother, not frigging talk eachother down.
I don't need to read those studies. I have enough common sense to know that efa requires vitamins, minerals, and amino acids to work properly...things that can only be found in whole seafood.
Imagine building a car that only has some but not all the necessary components. How is that car going to do on the road? Not very well. Same thing applies with nutrients and food and the human body.
Just now, Doctorcolumbus said:Ive been on these forums for 6-7 years (different account).
first, it is of absolute NO use to say somebody else is going in the wrong direction. I wish we would exploit 100 directions so maybe one of us finds the cure.
So stick to your own theory and keep everybody updated. You say the most widely studies herb ginko is rubbish, RSO is snake oil and you come back with TUDCA and EFA? Already used it.
So please, consider your theory just a different option and the other theory as different options and not a bad theory. We should help eachother, not frigging talk eachother down.
That's what I actually wanted to do, because my frustration made me do things you mentioned. Also I didn't mention RSO being snake oil, just the ginko. Jumping from one to another supplement isn't a way to go in my opinion. What was your TUDCA dosage and EFA?
2 minutes ago, Kunus999 said:That's what I actually wanted to do, because my frustration made me do things you mentioned. Also I didn't mention RSO being snake oil, just the ginko. Jumping from one to another supplement isn't a way to go in my opinion. What was your TUDCA dosage and EFA?
Tudca i did like a total of 75 grams. Maybe 750mg - 1000mg per day.
it is ofcourse a big help for the liver, the first few days it feels like it unclogs your liver, but then you feel again in aloop. It feels like after 2 weeks it wears off, so i cycled it.
efa not so long, did not make me feel so nice. A bit depressed, same goes for choline.