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Repairing the long-term damage from Accutane

 
MemberMember
397
(@calcified)

Posted : 02/16/2019 9:41 pm

9 hours ago, under_tow said:

Some longer water fasting and liver flushes have helped fat absorption immensely and no longer have any issues.

No folliculitis, but with the excessive sebum, was getting plugged pores, blackheads, whiteheads, etc, along with dandruff, very flaky facial skin, and blepharitis. These are finally starting to fade away. Acne was on upper arms/back/chest as well, all fading. I am actually shocked how much the skin can heal and normalize.

 

Edit: Should add that using HCl and bile acids for a few months, helped as well.

I have had blood test

vitamin A 1.9 range 1-3

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MemberMember
165
(@under_tow)

Posted : 02/17/2019 8:25 am

10 hours ago, Calcified said:

I have had blood test

vitamin A 1.9 range 1-3

Blood test is not reflective of what is stored in liver and fat tissues.

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MemberMember
397
(@calcified)

Posted : 02/17/2019 10:10 am

1 hour ago, under_tow said:

Blood test is not reflective of what is stored in liver and fat tissues.

I think a few hundred pages back some thought they were now deficient in vitamin a.

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MemberMember
165
(@under_tow)

Posted : 02/17/2019 10:25 am

10 minutes ago, Calcified said:

I think a few hundred pages back some thought they were now deficient in vitamin a.

Taking accutane in normal dosage 40mg to 80mg per day is roughly equivalent to 2.5 million IU to 5 million IU of vitamin A per day. Over a 6 month dosage length, the amounts are massive.

After accutane no one is deficient, they are absolutely overloaded in storage of liver and fat tissues.

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MemberMember
1803
(@guitarman01)

Posted : 02/17/2019 2:13 pm

On 2/11/2019 at 11:19 PM, StopAccutane said:

Actually,Bifidobacterium Longum exists in VSL#3.

different strains can have different effects, for example bifido longum bb536, is not the same as bifido longum 35624.

same species, different strain. it goes genus, species, then strain.

There could be genus wide effects, species wide or even certain strain effects that distinguish from other bacteria even of the same species.

 

 

by HM An - 2011 - Cited by 176- Related articles

Jul 12, 2011 -These data suggest that some specific strains ofbifidobacteriarelated tolipid metabolismand body weight may be potential therapeutic...

On 2/15/2019 at 10:34 AM, gutskinaxis said:

Have any of you done a microbiome analysis? I have some theories...

uBiomeuses machine learning, artificial intelligence, and advanced statistical techniques, as well as our patented precision sequencing process to analyze...
it would be nice to compare a few of these amongstourselves, ive been meaning to order one of their tests.

 

 

Also not including our own genes, it looks like we might be capable of passing on certain bacteria as well that could have a big impact on overall health. Im sure this idea isnt exclusive to this particular species.

New Genome Study of a Bifidobacterium subspecies by Morinaga Milk and APC Microbiome Ireland May Explain its Wide Distribution Across All Ages

http://apc.ucc.ie/unravelling-secrets-bifidobacteria-across-three-generations/

B. longumsubsp.longumis extensively transmitted between relatives, and that such transmission does not occur only between mothers and infants, as previously believed, but also between other family members and even across three generations.

It is a remarkable finding that not only was transmission between mother and child observed, but also between father and child and even between husband and wife. This is also the first report of a particular strain of gut microbiota that appears to have been transmitted across three generations in a family, for instance, between a grandmother, mother, and infant, stated Dr. Toshitaka Odamaki, Manager of Microbiota Research Dept. at Next Generation Science Institute of Morinaga and lead researcher of the study.

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MemberMember
10
(@deepacceptance)

Posted : 02/17/2019 2:34 pm

Hello everyone. Like my my name suggests I think that one of the keys to coping is to completely accept the situation for what it is.

My goal is to provide any one on this forum emotional support and insight. I took accelerated chemistry, 2 moths of organic chemistry before dropping out,and 3 semester of Biology in college and feel like I have a backbone of understand that may provide a relatively scientific explanation for what most people on here are experiencing, although I do not have a perfectly scientific understandingas some of you on here may have. This is why I would consider myself to be proficient in technical writing but not proficient in scientific writing. On the side, I have studiedpsychology although I only took one semester in college. In my opinion, accutanecauses chemical problems which translates first intobiochemicalproblems which creates physiological problems. I want to introduce things that have scientific fundamentals and be able to translate how this relates to the human experience. I want to conform to the standards of this sight to the maximum degree possible so if I ever say something that is not in alignment with your standards of acceptabilityplease do not hesitate to say something, any feedback on my posts are welcome. If you would like to have any sort of private conversation, please do not hesitate in emailing me. I do realize that my writing style mixes scientific ideas with subjective opinions, I think everyone has their subjective truth and in my writing I am attempting totruthfully disclosing what my subjective truth is.

I am 27 years old and started on accutane as a 20 year old. They say that a blind person is able to remember their sense of vision for 7 years at which point theystop remembering what the experience of vision is like, I think that is sort of what I am going through right now. I can't really remember what having the normal experience of the world is like any more. As the years of past, I have been forced to understand a lotto compensate for the deficits that I am experiencing post accutane. Understanding exactly how great the adversity is has been a journey, my main goal is to allow any one who is looking to understand what I have come to understand over the past 7 yearsquickly through my writing. I feel like my understanding has come full circle just in the past few days and this has inspired me to post on here although I accept that there is still a lot to learn. I have read through about 200 pages on here in the last 2 years although I have not posted on here. I have asked my personal doctor why I am having these problems and he along with any one I have talked to from the medical communityoutright deniesthe possibility that accutane could be doing anything other than clearing our skin and causing dry lips even though it is a chemotherapy drug. Whether this is due to a fundamental flaw in the medical system or only manifests for isotretinoinis not something I understand. The side effects listed are severe but they out right deny that it is causing permanent side effects and complications. This is why understanding these issues is close to impossible in my opinion. It is easy to look in the mirror and think that things have improved, in a way we are superficially oriented and it is very difficult to understand what might be wrong in our selves when their has been an improvement in our appearancelet alone having other people understand. I have tried to explain what has happened to my family as they have noticed the flaws in my character but do not understand why. Human beings have a deep need for connection, some psychologists have identified it as our highest need. In my experience of the world up until the age of 20 I suffered deeply from isolation andthis is what was driving me to take an extreme medication such as accutane.

If a movement to bring awareness to the problems that accutane has caused is occurring it is still in still in it'sinfancy. Likea giant snowball rolling down a hill, a cultural and civil movement starts slow but gains a critical mass where it develops an unstoppable momentum. In my opinion, we need to act collectively to and unify to stand any chance in this fight, acting independently, we stand little chance. Apoint of critical momentummay be on the near horizon if we unite and act collectively.

First I want to try to discusswhat is happening it's most fundamental level,the problem starts on a chemical level so that is what I am firstgoing to try to address. Accutane is a chemotherapy drug otherwise known as 13 cis retinoic acid. It is also used for Leukemia and Lung cancer as a chemotherapy drug but went on the market as an acnedrug in the 80's. Technically 13 cis retinoic acid is a derivative of vitamin A, this is why many people have identified the symptoms of PAS(Post Acccutane Syndrome) as being similar to vitamin A deficiency or Vitamin A toxicity. I amnot really sure which one it most closely resembles although if research actually goes into PAS this might be one of the first things that is identified, if Accutane truly does resemble Vitamin A deficiency or toxicity. Marketing Accutane as a vitamin A derivative is where I think that the first deceptions occur and this in my opinioncreates a false sense of security. Even though it is a vitaminA derivative, it is still chemo therapy drug and this is what the drug companies fail to reveal. I am life insurance agent and if we fail to reveal details such as this, it is considered fraud. I am not sure why pharmaceutical companies are not held to this same standard. to me this is the greatest injustice of Accutane.

Even if we were putting pure vitamin A into our bodies and this could actually be process by our bodies efficiently, as I understand, we are putting 25-100 times the normal levels of vitamin A into our systems. Since 13 cis retinoic acid it is not a naturally occurring chemical in thehuman body or at least only found in trace amountsin nature, our biology did not evolve to deal with13 cis retinoic acid in the quantities that it is prescribed in the form of accutane, as I understand, our bodies naturallylackthe enzymes to break down 13 cis retinoic acid as it is put into our systems especially in the quantities that accutane is prescribed. This is why the effects are generally permanent. When I first started looking into this, I intuitively perceivedthat there would be a chemical methodof reversing the alterations that accutane causes. However, there no such method, possibly because it has not been researched and possibly because there is not solution.Something that I think could be a solution is if we could synthetically create an enzyme that specifically targets 13 cis retinoic acid because from what I have read, the epigenetic(epigentic means a change in phenotype without a change in the DNA sequence) alternations are not reversible or curable in part because 13 cis retinoic acid is stored in various parts of the body but is never eliminated from the body. From what I understand, 13 cis retinoic acid stay with us for life.

The video that nature crazy created, which is the most watched youtube video on how to cleansefromaccutane,address thephysiological method of eliminating accutane but does not address that once 13 cis retinoic acid is stored, the liver, no matter how much bile flow is occurring,is not able to ridthe quantities of 13 cis retinoic acid that isstored in the body. I have done a lot research on this and there are some ideas out their such as cleansing the liver, fasting, and even finasteride. The flaw in this is that increasing bile flow is the general method of eliminating any toxin, while this may be good advice for your general health,I think that what weneed is a specific way of eliminating the toxin 13 cis retinoic acid. Where Iam still unsure of is if 13 cis retinoic acid was eliminated, if the chemical alternations that it initially causedwould be naturally re modified to restore the original biochemical structures that werealtered.

I think I have written enough for one post, today I attempted to address the chemistry of the isotretinoinalthough I know that there are holes in my understanding. Going forward, I will try to orient my writing more towards the human experience.

Quote
MemberMember
165
(@under_tow)

Posted : 02/17/2019 4:42 pm

2 hours ago, DeepAcceptance said:

Hello everyone. Like my my name suggests I think that one of the keys to coping is to completely accept the situation for what it is.

My goal is to provide any one on this forum emotional support and insight. I took accelerated chemistry, 2 moths of organic chemistry before dropping out,and 3 semester of Biology in college and feel like I have a backbone of understand that may provide a relatively scientific explanation for what most people on here are experiencing, although I do not have a perfectly scientific understandingas some of you on here may have. This is why I would consider myself to be proficient in technical writing but not proficient in scientific writing. On the side, I have studiedpsychology although I only took one semester in college. In my opinion, accutanecauses chemical problems which translates first intobiochemicalproblems which creates physiological problems. I want to introduce things that have scientific fundamentals and be able to translate how this relates to the human experience. I want to conform to the standards of this sight to the maximum degree possible so if I ever say something that is not in alignment with your standards of acceptabilityplease do not hesitate to say something, any feedback on my posts are welcome. If you would like to have any sort of private conversation, please do not hesitate in emailing me. I do realize that my writing style mixes scientific ideas with subjective opinions, I think everyone has their subjective truth and in my writing I am attempting totruthfully disclosing what my subjective truth is.

I am 27 years old and started on accutane as a 20 year old. They say that a blind person is able to remember their sense of vision for 7 years at which point theystop remembering what the experience of vision is like, I think that is sort of what I am going through right now. I can't really remember what having the normal experience of the world is like any more. As the years of past, I have been forced to understand a lotto compensate for the deficits that I am experiencing post accutane. Understanding exactly how great the adversity is has been a journey, my main goal is to allow any one who is looking to understand what I have come to understand over the past 7 yearsquickly through my writing. I feel like my understanding has come full circle just in the past few days and this has inspired me to post on here although I accept that there is still a lot to learn. I have read through about 200 pages on here in the last 2 years although I have not posted on here. I have asked my personal doctor why I am having these problems and he along with any one I have talked to from the medical communityoutright deniesthe possibility that accutane could be doing anything other than clearing our skin and causing dry lips even though it is a chemotherapy drug. Whether this is due to a fundamental flaw in the medical system or only manifests for isotretinoinis not something I understand. The side effects listed are severe but they out right deny that it is causing permanent side effects and complications. This is why understanding these issues is close to impossible in my opinion. It is easy to look in the mirror and think that things have improved, in a way we are superficially oriented and it is very difficult to understand what might be wrong in our selves when their has been an improvement in our appearancelet alone having other people understand. I have tried to explain what has happened to my family as they have noticed the flaws in my character but do not understand why. Human beings have a deep need for connection, some psychologists have identified it as our highest need. In my experience of the world up until the age of 20 I suffered deeply from isolation andthis is what was driving me to take an extreme medication such as accutane.

If a movement to bring awareness to the problems that accutane has caused is occurring it is still in still in it'sinfancy. Likea giant snowball rolling down a hill, a cultural and civil movement starts slow but gains a critical mass where it develops an unstoppable momentum. In my opinion, we need to act collectively to and unify to stand any chance in this fight, acting independently, we stand little chance. Apoint of critical momentummay be on the near horizon if we unite and act collectively.

First I want to try to discusswhat is happening it's most fundamental level,the problem starts on a chemical level so that is what I am firstgoing to try to address. Accutane is a chemotherapy drug otherwise known as 13 cis retinoic acid. It is also used for Leukemia and Lung cancer as a chemotherapy drug but went on the market as an acnedrug in the 80's. Technically 13 cis retinoic acid is a derivative of vitamin A, this is why many people have identified the symptoms of PAS(Post Acccutane Syndrome) as being similar to vitamin A deficiency or Vitamin A toxicity. I amnot really sure which one it most closely resembles although if research actually goes into PAS this might be one of the first things that is identified, if Accutane truly does resemble Vitamin A deficiency or toxicity. Marketing Accutane as a vitamin A derivative is where I think that the first deceptions occur and this in my opinioncreates a false sense of security. Even though it is a vitaminA derivative, it is still chemo therapy drug and this is what the drug companies fail to reveal. I am life insurance agent and if we fail to reveal details such as this, it is considered fraud. I am not sure why pharmaceutical companies are not held to this same standard. to me this is the greatest injustice of Accutane.

Even if we were putting pure vitamin A into our bodies and this could actually be process by our bodies efficiently, as I understand, we are putting 25-100 times the normal levels of vitamin A into our systems. Since 13 cis retinoic acid it is not a naturally occurring chemical in thehuman body or at least only found in trace amountsin nature, our biology did not evolve to deal with13 cis retinoic acid in the quantities that it is prescribed in the form of accutane, as I understand, our bodies naturallylackthe enzymes to break down 13 cis retinoic acid as it is put into our systems especially in the quantities that accutane is prescribed. This is why the effects are generally permanent. When I first started looking into this, I intuitively perceivedthat there would be a chemical methodof reversing the alterations that accutane causes. However, there no such method, possibly because it has not been researched and possibly because there is not solution.Something that I think could be a solution is if we could synthetically create an enzyme that specifically targets 13 cis retinoic acid because from what I have read, the epigenetic(epigentic means a change in phenotype without a change in the DNA sequence) alternations are not reversible or curable in part because 13 cis retinoic acid is stored in various parts of the body but is never eliminated from the body. From what I understand, 13 cis retinoic acid stay with us for life.

The video that nature crazy created, which is the most watched youtube video on how to cleansefromaccutane,address thephysiological method of eliminating accutane but does not address that once 13 cis retinoic acid is stored, the liver, no matter how much bile flow is occurring,is not able to ridthe quantities of 13 cis retinoic acid that isstored in the body. I have done a lot research on this and there are some ideas out their such as cleansing the liver, fasting, and even finasteride. The flaw in this is that increasing bile flow is the general method of eliminating any toxin, while this may be good advice for your general health,I think that what weneed is a specific way of eliminating the toxin 13 cis retinoic acid. Where Iam still unsure of is if 13 cis retinoic acid was eliminated, if the chemical alternations that it initially causedwould be naturally re modified to restore the original biochemical structures that werealtered.

I think I have written enough for one post, today I attempted to address the chemistry of the isotretinoinalthough I know that there are holes in my understanding. Going forward, I will try to orient my writing more towards the human experience.

13 cis retinoic is eliminated from the body just like normal all-trans-retinoic acid is removed. 13-cis is just a mirror image of ATRA, hence is was patent-able like 9-cis was. Easiest way to get the massive amounts out from the accutane rounds is to eat a zero vitamin A diet.

 

 

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MemberMember
10
(@deepacceptance)

Posted : 02/17/2019 5:39 pm

57 minutes ago, under_tow said:

13 cis retinoic is eliminated from the body just like normal all-trans-retinoic acid is removed. 13-cis is just a mirror image of ATRA, hence is was patent-able like 9-cis was. Easiest way to get the massive amounts out from the accutane rounds is to eat a zero vitamin A diet.

 

 

Yes I just learned this watching a video from "best person ever" on youtube. It sounds like the damage has all ready been done. What are the mechanisms that it most directly affects? I learned today that telomerase it severely down regulated. I heard that thiscauses telomere shortening. This and the fact that it damages the myelin sheathis probably what frightens me the most. From my understanding, fasting is the only way to cleanse down to the cellular level. It seems like this may have a mild effect. Funding is so limited for research because the medical community does notacknowledges that it's mechanisms are the same as chemotherapy. It doesn't seem like research would do anything though because no one has found a way to cure the damaged mechanisms after chemotherapy. Do you have any reason to think that this is incorrect?

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MemberMember
17
(@gutskinaxis)

Posted : 02/17/2019 7:24 pm

1 hour ago, DeepAcceptance said:

Yes I just learned this watching a video from "best person ever" on youtube. It sounds like the damage has all ready been done. What are the mechanisms that it most directly affects? I learned today that telomerase it severely down regulated. I heard that thiscauses telomere shortening. This and the fact that it damages the myelin sheathis probably what frightens me the most. From my understanding, fasting is the only way to cleanse down to the cellular level. It seems like this may have a mild effect. Funding is so limited for research because the medical community does notacknowledges that it's mechanisms are the same as chemotherapy. It doesn't seem like research would do anything though because no one has found a way to cure the damaged mechanisms after chemotherapy. Do you have any reason to think that this is incorrect?

Nicotinamide Riboside may be able to reverse these effects.

Telomerase function is due in part to sirtuin proteins. These sirtuins are dependent on NAD+. Nicotinamide riboside is a NAD+ precursor that decreases as we age. Boosting levels of NAD+ may be able to restore and up regulate telomerase function. There is more info here: https://www.fightagainstacne.com/blog/anti-aging-compound-fights-acne

Myelin sheath I need to do more research.

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MemberMember
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(@deepacceptance)

Posted : 02/17/2019 8:24 pm

53 minutes ago, gutskinaxis said:

Nicotinamide Riboside may be able to reverse these effects.

Telomerase function is due in part to sirtuin proteins. These sirtuins are dependent on NAD+. Nicotinamide riboside is a NAD+ precursor that decreases as we age. Boosting levels of NAD+ may be able to restore and up regulate telomerase function. There is more info here: https://www.fightagainstacne.com/blog/anti-aging-compound-fights-acne

Myelin sheath I need to do more research.

The damage to the myelin sheath happens in all chemo therapies. It keepsthe myelin sheath from being able to repair itself. Personallythere are other things that are really bothering me, I have had my testosterone checked and I am 237ng/dl when the normal range is around 600-1000ng/dl for some one my age. I went to a naturalpathic doctor and she identified that I have an auto immune disorder when my immune system is attacking my endocrine system which includes my reproductive system and adrenal glands. I can't help but think that this was caused by accutane. How expensive is NAD+?

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17
(@gutskinaxis)

Posted : 02/17/2019 8:33 pm

8 minutes ago, DeepAcceptance said:

The damage to the myelin sheath happens in all chemo therapies. It keepsthe myelin sheath from being able to repair itself. Personallythere are other things that are really bothering me, I have had my testosterone checked and I am 237ng/dl when the normal range is around 600-1000ng/dl for some one my age. I went to a naturalpathic doctor and she identified that I have an auto immune disorder when my immune system is attacking my endocrine system which includes my reproductive system and adrenal glands. I can't help but think that this was caused by accutane. How expensive is NAD+?

Hmm. I think intermittent fasting and a really sound diet help a lot of these issues. It puts less stress on your liver. Great diets and fasting have been shown to really help injured livers and kidneys. Nicotinamide Riboside is not too expensive at all.

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MemberMember
1753
(@truejustice)

Posted : 02/17/2019 8:57 pm

When Undertow said about Tane it peels you on the inside I thinks thats accurate to be honest.

I mean if our outer features are anything to judge by - thinning skin, thin hair, no oil etc, stands to reason that the same thing is happening on the inside yeah?

How to stop it, I would not know. All you can do is address the symptoms and work on them one by one.

1. Calm nervous system

2. Diagnose allergies ( Gluten for ex ) clean up gut & liver. This includes adjustments and supplementing along with avoiding certain foods.

3. Repair HPA Axis

Havent discussed with Kinesiologist what comes next as its now been6 months just working on these 3 steps....

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299
(@macleod)

Posted : 02/18/2019 1:44 am

6 hours ago, gutskinaxis said:

Nicotinamide Riboside may be able to reverse these effects.

Telomerase function is due in part to sirtuin proteins. These sirtuins are dependent on NAD+. Nicotinamide riboside is a NAD+ precursor that decreases as we age. Boosting levels of NAD+ may be able to restore and up regulate telomerase function. There is more info here: https://www.fightagainstacne.com/blog/anti-aging-compound-fights-acne

Myelin sheath I need to do more research.

I've been researching NMN lately. Nicotinamide Mononucleotide. Watched a few interviews with Hardvard professor David Sinclair and his self treatment of NMN, Reservatrol, and Metformin for anti-aging purposes.

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MemberMember
17
(@gutskinaxis)

Posted : 02/18/2019 1:53 am

8 minutes ago, macleod said:

I've been researching NMN lately. Nicotinamide Mononucleotide. Watched a few interviews with Hardvard professor David Sinclair and his self treatment of NMN, Reservatrol, and Metformin for anti-aging purposes.

 

Yes, NMN is basically the same thing as Nicotinamide Riboside.

Quote
MemberMember
165
(@under_tow)

Posted : 02/18/2019 7:38 am

On 2/18/2019 at 7:57 AM, TrueJustice said:

When Undertow said about Tane it peels you on the inside I thinks thats accurate to be honest.

I mean if our outer features are anything to judge by - thinning skin, thin hair, no oil etc, stands to reason that the same thing is happening on the inside yeah?

How to stop it, I would not know. All you can do is address the symptoms and work on them one by one.

1. Calm nervous system

2. Diagnose allergies ( Gluten for ex ) clean up gut & liver. This includes adjustments and supplementing along with avoiding certain foods.

3. Repair HPA Axis

Havent discussed with Kinesiologist what comes next as its now been6 months just working on these 3 steps....

The only way to heal is to remove vitamin A from diet, this will deplete accutane from your body and allow healing to begin:

[removed]

Quote
MemberMember
0
(@kolonie)

Posted : 02/18/2019 9:03 am

ACCUTANE SWEATING PROBLEM

 

 

Hey,

sorry for my bad english, I am from germany and wrote this with google translator:

I took 10mg accutane for 6 months and still have serious side effects even though I have not taken any accutane for over a year.

I have hot flashes, it is an inner heat that always comes up in me and I sweat a lot. that is so extreme that it strongly influences my life. 15 degrees are enough and my forehead is constantly wet. When I go out in the summer, my back is constantly wet. I can only wear black. I tried everything and was with many doctors, but no one could help me.
does anyone have experience here and can help me? that is very bad for me.
Thank you.
Quote
MemberMember
397
(@calcified)

Posted : 02/18/2019 9:40 am

23 hours ago, under_tow said:

Taking accutane in normal dosage 40mg to 80mg per day is roughly equivalent to 2.5 million IU to 5 million IU of vitamin A per day. Over a 6 month dosage length, the amounts are massive.

After accutane no one is deficient, they are absolutely overloaded in storage of liver and fat tissues.

I have been taking 30000iu retinol palmitate daily under doc's supervision to reduce my sides.

Quote
MemberMember
165
(@under_tow)

Posted : 02/18/2019 10:02 am

20 minutes ago, Calcified said:

I have been taking 30000iu retinol palmitate daily under doc's supervision to reduce my sides.

Retinol palmitate is the synthetic vitamin A, and probably the worst one to take. I did high dose retinyl palmitate (300K to 500K/day), did nothing. zero vitamin A is the way to go.

Quote
MemberMember
397
(@calcified)

Posted : 02/18/2019 10:51 am

43 minutes ago, under_tow said:

Retinol palmitate is the synthetic vitamin A, and probably the worst one to take. I did high dose retinyl palmitate (300K to 500K/day), did nothing. zero vitamin A is the way to go.

Zero makes my fat malabsorption worse.

Quote
MemberMember
5
(@francisco-blanquez)

Posted : 02/18/2019 3:06 pm

Do you think there is still vit A from roacutan after 30 years inmy liver?

Quote
MemberMember
1753
(@truejustice)

Posted : 02/18/2019 3:14 pm

On 2/18/2019 at 6:38 PM, under_tow said:

The only way to heal is to remove vitamin A from diet, this will deplete accutane from your body and allow healing to begin:

[removed]

I dont completely agree

No amount of either avoiding Vit A or on the flip side consuming Vit A will fix a dysfunctional HPA Axis

Not suggesting everyone has this issue to deal with but I do. I would bet my bottom dollar that the same would apply to those with say Erectile dysfunction - highly doubtful just by avoiding A that this problem will be fixed yeah

Happy to be proven wrong though....

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MemberMember
1
(@user2)

Posted : 02/18/2019 4:23 pm

On 1/26/2019 at 7:56 PM, Calcified said:
1 hour ago, TrueJustice said:

 

Like many have suggested here, I believe the answer is likely connected with our gut and liver. If Accutane damaged our intestinal lining by causing it to dry out or by killing beneficial bacterial or by simply making it inhospitable for good bacteria; I cant help but think relief may be possible through repair. Perhaps proper nutrition coupled with getting our liver functioning correctly will accelerate the process.

It seems particular probiotics have been identified as assisting with the metabolism of fats while others are said to be helpful with mental side effects many here have mentioned such as anxiety, depression and motivation. Please take a look at the links below and let me know what you think. (I apologize if I am repeating information posted by others earlier.)

Many have mentioned they have issues digesting fats. Perhaps this information may be useful: https://articles.mercola.com/sites/articles/archive/2012/10/01/gut-bacteria-on-fat-absorption.aspx

Has anyone tried supplementing with specific probiotics to combat anxiety or increase motivation? If seems Lactobacillus & Bifidobacterium help with reducing anxiety and Bacillus & Serratia increase dopamine to asset with motivation.

https://universityhealthnews.com/daily/depression/best-probiotics-for-mood-enhancing-the-gut-brain-connection-with-psychobiotics/

https://www.psychologytoday.com/us/blog/urban-survival/201809/can-probiotics-help-reduce-anxiety

The Gut-Brain Axis: The Missing Link in Depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662178/

However, having said this, I remembered reading someones comment about having had several fecal replacements with no improvements, which is contrary to the above. Perhaps the perfect gut biome for one isnt ideal for another.

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MemberMember
165
(@under_tow)

Posted : 02/18/2019 5:45 pm

6 hours ago, Calcified said:

Zero makes my fat malabsorption worse.

So high dose vitamin A(accutane) gave you fat malabsorption, and now you are taking high dose vitamin A to fix it? Doesn't make sense.

high dose vitamin A screws with NADPH, which means no bile. Depleting vitA, liver flushes are the way to go, using HCl, adequate sodium, bile acids, will work along side this.

2 hours ago, TrueJustice said:

I dont completely agree

No amount of either avoiding Vit A or on the flip side consuming Vit A will fix a dysfunctional HPA Axis

Not suggesting everyone has this issue to deal with but I do. I would bet my bottom dollar that the same would apply to those with say Erectile dysfunction - highly doubtful just by avoiding A that this problem will be fixed yeah

Happy to be proven wrong though....

 

If high dose vitamin A broke your HPA, why wouldn't depleting it help? Eating zero vitamin A is quite simple, and easy to test.

Accutane isn't some magical drug concocted in a secret lab, it is high dose active vitamin A, it gets stored in fat and liver to protect you, its needs to be depleted, and when removed the body will heal. The normal western diet, has adequate(pork, dairy, bright colored greens/fruit/vegg) vitamin A to keep in locked in storage.

 

 

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MemberMember
1753
(@truejustice)

Posted : 02/18/2019 6:12 pm

I wish it was that easy.

The problem after 20 years is that the damage accumulates, regardless of theories other problems arise yeah namely gut lining and liver is damaged.

I wish fixing HPA was as easy as either avoiding Gluten, avoiding Vit A or doing some fasting but its not.

I even tried the YouTube video of taking Calcium d glucarate and Chinese bitters etc to rid any stored Accutane-Ive done the Moritz liver/gallbladder cleanses by the book - no change at all.

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MemberMember
397
(@calcified)

Posted : 02/18/2019 10:24 pm

3 hours ago, TrueJustice said:

I wish it was that easy.

The problem after 20 years is that the damage accumulates, regardless of theories other problems arise yeah namely gut lining and liver is damaged.

I wish fixing HPA was as easy as either avoiding Gluten, avoiding Vit A or doing some fasting but its not.

I even tried the YouTube video of taking Calcium d glucarate and Chinese bitters etc to rid any stored Accutane-Ive done the Moritz liver/gallbladder cleanses by the book - no change at all.

Yes things do seem to popup years later.

I'm just trialling vitamin a for a fortnight, then check bloods.

Honestly my stomach is more settled, so hopefully when I stop it doesn't comeback, also I only had fat malabsorption issues after I corrected my low vitamin d and fasting didn't help.

User2 - if it does come back I'll give probiotics a go.

Under_tow - I used to think accutane was stored in us, but im not too sure now.

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