A couple of test panels that have been borderline for me.
ANTIPHOSPHOLIPID ANTIBODY PANEL
LUPUS ANTICOAGULANT EVALUATION WITH REFLEX
Ive been supplementing 360 mk7 everyday for quite awhile now and the previous test was positive and the most recent test was negative. Im still taking this with a grain of salt though atm. (it was also done through two different labs)
Vitamin K is responsible for both coagulationand anticoagulationfactors.

10 minutes ago, fiksi said:

increases cell death

Cell death doesn't have to be permanent depending on the situation. They could come back.
I hate using analogies but I could scratch my skin or shave my face and kill some cells. They come back though.
Obviously Accutane is on a much larger scale.
If there is a driving force that continues to push things in the wrong direction though, it's probably a crippled process.

17 minutes ago, guitarman01 said:

 

Cell death doesn't have to be permanent depending on the situation. They could come back.
I hate using analogies but I could scratch my skin or shave my face and kill some cells. They come back though.
Obviously Accutane is on a much larger scale.
If there is a driving force that continues to push things in the wrong direction though, it's probably a crippled process.

I agree, normally it's a circular process... but in this case it can be permanent. Roche have admitted, and many cases have presented, with irreversible changes. It seems tane is not only inducing cell death, but altering many other things in the gland as well.

@mariovitaliHere is some cell growth right here. Ive been looking strictly at mk7. I'm not sure if there is a case for mk4.
mk4 is already a drug in Japan. It looks like mk7 is going to enter the drug market.

Vitamin K2-enhanced liver regeneration is associated with oval cell expansion and up-regulation of matrilin-2 expression in 2-AAF/PH rat model.

vitamin K2 treatment enhances liver regeneration
https://www.ncbi.nlm.nih.gov/pubmed/24236453
K2 also grows and developsthe liver postpartumfrom birth. It looks like bacteria is also involved, meaning it might originatefrom a long chain menaquinone.

Heres Cell Death. No k2 is Embryonic Lethal.
Vitamin K₂Biosynthetic Enzyme, UBIAD1 Is Essential for Embryonic Development of Mice

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104078

This is what im talking about, k2 growing liver cells.
Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes.
https://www.ncbi.nlm.nih.gov/pubmed/25808545

So my finasteride just arrived in the mail. Is microdosing it the theory or just a short period of taking it? It's only 1mg.

Hoping it'll re-sensitize me to dht, but worse case it'll help prevent further hairloss.

On 12/31/2017 at 9:53 AM, namelk said:

I did not feel anything, it's been 5 days since I stopped taking it and I did not feel exactly anything, it seems that my libido has decreased even more so now that I stopped, it only served to make me fucking that **** even more, I was hoping for it .. .

I will wait another 2 days, if nothing happens I will take it for another 25 days

 

my hair still falls when I pull with my hand a little

@QuietSoldier Talk to this guy.

In just one glad accutane alters 6000 genes thats insane wow. I call it modern day witch craft.

2 hours ago, QuietSoldier said:

So my finasteride just arrived in the mail. Is microdosing it the theory or just a short period of taking it? It's only 1mg.

Hoping it'll re-sensitize me to dht, but worse case it'll help prevent further hairloss.

Good luck with that insane drug.
Personally I wouldnt touch ANY pharmaceutical after my experience with tan. But you seem dumb enough.

14 minutes ago, Gladiatoro said:

In just one glad accutane alters 6000 genes thats insane wow. I call it modern day witch craft.

Now, this is just one gland... what about brain, gut etc? I did not have many side effects even form logn term antibiotics, from this s...t after few months I developed extreme symptoms.

Derms often say- don't worry, you'll just have dry lips... another poster today found blood in stool on accutane. This could be the beginning of Crohn's, IBS, or what else who knows. YOu may trade acne for another lifelong serious condition.

The only thing Ive ever heard some Derms recommend patients with side effects is supplementing Vit A.

Does anyone have a theory on how this would stop tane side effects??

4 minutes ago, TrueJustice said:

The only thing Ive ever heard some Derms recommend patients with side effects is supplementing Vit A.

Does anyone have a theory on how this would stop tane side effects??

I heard no A form and after you end for a while at all.

Tane is an A derivative, but effects of overdosing on both are similar... I woudl say you are stressing your body and making teh situation worse.

No thats not the case in the examples Im asking about, patients got side effects and the Derm put them on Vit A - things like headaches and peeling skin apparently subsided.....

How did this happen?? No derailing please, I really want to know from those who understand the science better than others!!

One poster went on 5 rounds of isotretinoin , and he is still breathing crazy world we live in.

Im shocked and amazed at the same time btw he still has acne so my cure rate rating for isotretinoin should be more like 10 % vs 60.

1 hour ago, TrueJustice said:

No thats not the case in the examples Im asking about, patients got side effects and the Derm put them on Vit A - things like headaches and peeling skin apparently subsided.....

Yep.

https://www.ncbi.nlm.nih.gov/pubmed/8319203

"Patients taking these drugs [Accutane] often show side effects resembling the symptoms of hypovitaminosis A, namely, night blindness and decreased plasma retinol levels. A dietary vitamin A deficiency is not suspected in these patients; therefore, interference with normal vitamin A metabolism seems likely. The effect of these drugs on two enzymes involved in vitamin A metabolism was investigated. At micromolar concentrations, all three derivatives were found to inhibit intestinal lecithin-retinol acyltransferase (LRAT) and to a lesser extent liver LRAT and intestinal retinal reductase. . . .The ability of these drugs to inhibit retinal reduction and retinol esterification in vitro suggests an ability [for Accutane] to interfere with normal vitamin A metabolism in vivo, particularly during absorption."

http://www.ncbi.nlm.nih.gov/pubmed/10570558

"A 16-year-old male developed night blindness 2 weeks after starting isotretinoin at a dose of 20 mg per day for cystic acne. He also had cystic fibrosis, complicated by hepatic cirrhosis. . . . Oral vitamin A replacement was instituted with resolution of his visual symptoms in 6 months."

https://www.ncbi.nlm.nih.gov/pubmed/9481625

"Children and young adults with active IBD frequently have low serum levels of vitamin A or vitamin E. The severity of disease activity is a better predictor of risk for hypovitaminosis than is nutritional status"

Danby FW. Oral isotretinoin, neuropathy and hypovitaminosis A. Clin Exp Dermatol. 2008;33(2):190.

"A physician published a letter earlier this year reporting that two patients developed depression on Accutane; when the physician took them off the drug and supplemented them with 10-12,000 IU of vitamin A for seven to ten days, the depression resolved and they were able to go back on the drug without it recurring."

Interference with vitamin A metabolism is the likely reason some Accutane users feel better on vitamin A. Accutane is not full vitamin A, but instead a metabolite. So by supplementing it in mega-doses (i.e., taking Accutane) your body is missing out on a key aspect of vitamin A. Avoiding vitamin A is not necessarily a good idea. In fact, it may be entirely counter-productive.

2 hours ago, Gladiatoro said:

Good luck with that insane drug. (Propecia)

Personally I would touch ANY pharmaceutical after my experience with tan. But you seem dumb enough.

I will never understand why people are taking Propecia to manage post-Accutane side effects when the origin for that theory is based upon a doctor who claimed brief sexual recovery, only to later express feeling worse from the experiment. Even in theory, micro-dosing Propecia makes no sense. The drug in its prescribed doses already up-regulates androgen receptors, yet men obviously develop a bunch of symptoms of hypogonadism. Micro-dosing it may make some semblance of sense if prescribed doses down-regulated androgen receptors, so then you may reason micro-dosing the drug would only block receptors temporarily so they could up-regulate. But that's not at all how it works.

Your not as dumb as most on here in fact your pretty smart for your age .

In the end we are dealing with symptom management nothing more nothing less , and remember the most important part dont mess with your skin , trust me on this one I learned the hard way , our skin receptors are permanently &$(up. 22 years later after tan exposure I put the puzzle together , piece by piece.

1 hour ago, ACCUiTy_drANE said:

Yep.

https://www.ncbi.nlm.nih.gov/pubmed/8319203

"Patients taking these drugs [Accutane] often show side effects resembling the symptoms of hypovitaminosis A, namely, night blindness and decreased plasma retinol levels. A dietary vitamin A deficiency is not suspected in these patients; therefore, interference with normal vitamin A metabolism seems likely. The effect of these drugs on two enzymes involved in vitamin A metabolism was investigated. At micromolar concentrations, all three derivatives were found to inhibit intestinal lecithin-retinol acyltransferase (LRAT) and to a lesser extent liver LRAT and intestinal retinal reductase. . . .The ability of these drugs to inhibit retinal reduction and retinol esterification in vitro suggests an ability [for Accutane] to interfere with normal vitamin A metabolism in vivo, particularly during absorption."

http://www.ncbi.nlm.nih.gov/pubmed/10570558

"A 16-year-old male developed night blindness 2 weeks after starting isotretinoin at a dose of 20 mg per day for cystic acne. He also had cystic fibrosis, complicated by hepatic cirrhosis. . . . Oral vitamin A replacement was instituted with resolution of his visual symptoms in 6 months."

https://www.ncbi.nlm.nih.gov/pubmed/9481625

"Children and young adults with active IBD frequently have low serum levels of vitamin A or vitamin E. The severity of disease activity is a better predictor of risk for hypovitaminosis than is nutritional status"

Danby FW. Oral isotretinoin, neuropathy and hypovitaminosis A. Clin Exp Dermatol. 2008;33(2):190.

"A physician published a letter earlier this year reporting that two patients developed depression on Accutane; when the physician took them off the drug and supplemented them with 10-12,000 IU of vitamin A for seven to ten days, the depression resolved and they were able to go back on the drug without it recurring."

Interference with vitamin A metabolism is the likely reason some Accutane users feel better on vitamin A. Accutane is not full vitamin A, but instead a metabolite. So by supplementing it in mega-doses (i.e., taking Accutane) your body is missing out on a key aspect of vitamin A. Avoiding vitamin A is not necessarily a good idea. In fact, it may be entirely counter-productive.
I will never understand why people are taking Propecia to manage post-Accutane side effects when the origin for that theory is based upon a doctor who claimed brief sexual recovery, only to later express feeling worse from the experiment. Even in theory, micro-dosing Propecia makes no sense. The drug in its prescribed doses already up-regulates androgen receptors, yet men obviously develop a bunch of symptoms of hypogonadism. Micro-dosing it may make some semblance of sense if prescribed doses down-regulated androgen receptors, so then you may reason micro-dosing the drug would only block receptors temporarily so they could up-regulate. But that's not at all how it works.

Thanks ACCUiTy

I know I asked not long ago but again, what are you taking these days?

What are your must haves via diet or supplements plus some other things worth considering? Perhaps expand on why you are taking them?

At the same time, what have you discarded in recent times?

49 minutes ago, TrueJustice said:

I know I asked not long ago but again, what are you taking these days?

What are your must haves via diet or supplements plus some other things worth considering? Perhaps expand on why you are taking them?

At the same time, what have you discarded in recent times?

Well, recently IBS has flared up so I have been trying to focus on that. I have also been dealing with anal fissures for some unknown reason (inflammation?). When my IBS was at its best, the main difference was that I was running frequently instead of lifting. So I have recently got back into running, which may have been more important to my health than I once appreciated. Anyway, right now I am taking all of the following:

Co Enzyme Q10
Maqui berry extract thanks to dry eye syndrome catching up to me. (Surprise, surprise.)
Magnesium Citrate (Seemed to help my IBS in the past.)
Caffeine
Agmatine (Seemed to help my psychiatric symptoms in the past.)
Carnosine (Promotes telomerase activity and is capable of increasing the lifespan of mice significantly.)
PQQ (One post-Accutane user had good luck with this, and it seems capable of repairing damaged brain cells.)
Acetyl-l-Carnitine (Clears my head.)
Align probiotic
Citrucel fiber supplement

I am no longer taking Sarcosine, Tianeptine, or NAC. NAC aggravated IBS, Sarcosine made ED worse despite helping my mental functioning significantly, and Tianeptine has run its course. I do not want to be taking it forever. I am contemplating going back on low-dose Naltrexone as well. Essentially, I want to mimic whatever I was doing when my IBS was highly manageable. As a side note to anyone else reading this, Agmatine and LDN may help erection health as well.

Feeling brain-dead, impotent, and chronically bloated is not exactly useful for the dating world. It really seems to be a delicate balancing act to keep all three issues at bay. The antioxidants I take definitely help me feel more grounded. I still have trouble following conversations, and anhedonia creeps up at times. But I am way better than I once was. I will feel much better once I get my IBS back under control.

11 minutes ago, ACCUiTy_drANE said:

Well, recently IBS has flared up so I have been trying to focus on that. I have also been dealing with anal fissures for some unknown reason (inflammation?). When my IBS was at its best, the main difference was that I was running frequently instead of lifting. So I have recently got back into running, which may have been more important to my health than I once appreciated. Anyway, right now I am taking all of the following:

Co Enzyme Q10
Maqui berry extract thanks to dry eye syndrome catching up to me. (Surprise, surprise.)
Magnesium Citrate (Seemed to help my IBS in the past.)
Caffeine
Agmatine (Seemed to help my psychiatric symptoms in the past.)
Carnosine (Promotes telomerase activity and is capable of increasing the lifespan of mice significantly.)
PQQ (One post-Accutane user had good luck with this, and it seems capable of repairing damaged brain cells.)
Acetyl-l-Carnitine (Clears my head.)
Align probiotic
Citrucel fiber supplement

I am no longer taking Sarcosine, Tianeptine, or NAC. NAC aggravated IBS, Sarcosine made ED worse despite helping my mental functioning significantly, and Tianeptine has run its course. I do not want to be taking it forever. I am contemplating going back on low-dose Naltrexone as well. Essentially, I want to mimic whatever I was doing when my IBS was highly manageable. As a side note to anyone else reading this, Agmatine and LDN may help erection health as well.

Feeling brain-dead, impotent, and chronically bloated is not exactly useful for the dating world. It really seems to be a delicate balancing act to keep all three issues at bay. The antioxidants I take definitely help me feel more grounded. I still have trouble following conversations, and anhedonia creeps up at times. But I am way better than I once was. I will feel much better once I get my IBS back under control.

Its heart breaking what your going through for no GOD damn reason. Dont worry your NOT alone. We are after all a brotherhood bonded by $cience.

12 minutes ago, ACCUiTy_drANE said:

Well, recently IBS has flared up so I have been trying to focus on that. I have also been dealing with anal fissures for some unknown reason (inflammation?). When my IBS was at its best, the main difference was that I was running frequently instead of lifting. So I have recently got back into running, which may have been more important to my health than I once appreciated. Anyway, right now I am taking all of the following:

Co Enzyme Q10
Maqui berry extract thanks to dry eye syndrome catching up to me. (Surprise, surprise.)
Magnesium Citrate (Seemed to help my IBS in the past.)
Caffeine
Agmatine (Seemed to help my psychiatric symptoms in the past.)
Carnosine (Promotes telomerase activity and is capable of increasing the lifespan of mice significantly.)
PQQ (One post-Accutane user had good luck with this, and it seems capable of repairing damaged brain cells.)
Acetyl-l-Carnitine (Clears my head.)
Align probiotic
Citrucel fiber supplement

I am no longer taking Sarcosine, Tianeptine, or NAC. NAC aggravated IBS, Sarcosine made ED worse despite helping my mental functioning significantly, and Tianeptine has run its course. I do not want to be taking it forever. I am contemplating going back on low-dose Naltrexone as well. Essentially, I want to mimic whatever I was doing when my IBS was highly manageable. As a side note to anyone else reading this, Agmatine and LDN may help erection health as well.

Feeling brain-dead, impotent, and chronically bloated is not exactly useful for the dating world. It really seems to be a delicate balancing act to keep all three issues at bay. The antioxidants I take definitely help me feel more grounded. I still have trouble following conversations, and anhedonia creeps up at times. But I am way better than I once was. I will feel much better once I get my IBS back under control.

Thanks for update!!

CoQ10 - Im back on that too, esp in light of tane possibly affecting heart health.

Im also still doing Omega oils - to combat cholesterol and just because its good for you.

What are your thoughts on supplementing Vit K and Vit A??

Perhaps one is better off just getting correct amounts of these via diet?

i currently believe tane sides are due to liver damage caused by bile stagnation which ultimately causes derangement in steroid metabolism.

and i believe a diet very high in vitamin c, (possibly with supplemental ascorbate), is mandatory and critical if anyone wants a chance at recovery.

2 hours ago, ACCUiTy_drANE said:

Well, recently IBS has flared up so I have been trying to focus on that. I have also been dealing with anal fissures for some unknown reason (inflammation?). When my IBS was at its best, the main difference was that I was running frequently instead of lifting. So I have recently got back into running, which may have been more important to my health than I once appreciated. Anyway, right now I am taking all of the following:

Co Enzyme Q10
Maqui berry extract thanks to dry eye syndrome catching up to me. (Surprise, surprise.)
Magnesium Citrate (Seemed to help my IBS in the past.)
Caffeine
Agmatine (Seemed to help my psychiatric symptoms in the past.)
Carnosine (Promotes telomerase activity and is capable of increasing the lifespan of mice significantly.)
PQQ (One post-Accutane user had good luck with this, and it seems capable of repairing damaged brain cells.)
Acetyl-l-Carnitine (Clears my head.)
Align probiotic
Citrucel fiber supplement

I am no longer taking Sarcosine, Tianeptine, or NAC. NAC aggravated IBS, Sarcosine made ED worse despite helping my mental functioning significantly, and Tianeptine has run its course. I do not want to be taking it forever. I am contemplating going back on low-dose Naltrexone as well. Essentially, I want to mimic whatever I was doing when my IBS was highly manageable. As a side note to anyone else reading this, Agmatine and LDN may help erection health as well.

Feeling brain-dead, impotent, and chronically bloated is not exactly useful for the dating world. It really seems to be a delicate balancing act to keep all three issues at bay. The antioxidants I take definitely help me feel more grounded. I still have trouble following conversations, and anhedonia creeps up at times. But I am way better than I once was. I will feel much better once I get my IBS back under control.

Did you ever take antibiotics ?

1 hour ago, pimple pimp said:

i currently believe tane sides are due to liver damage caused by bile stagnation which ultimately causes derangement in steroid metabolism.

and i believe a diet very high in vitamin c, (possibly with supplemental ascorbate), is mandatory and critical if anyone wants a chance at recovery.

You just have to take Vit C??

So you dont have to do any Liver/Gallbladder cleanses, which if done by the book involve colonic irrigation, fasting, avoiding certain foods, oil mixtures etc etc to cleanse both liver & Gallbladder, possibly done many times to get desired results.

Are you saying just get on Vit C, dont bother with time consuming cleanses?

That is interesting with regards to Vitamin A, but most info related to patients experiencing symptoms of low vitamin A while on a courses of Tane.

Im wondering how people fared trying A years after ceasing?

About 3 years after ceasing, (back in 2010,) I tried a retinyl supplement, but it caused a rapid worsening of mood, and headaches/ less sleep. Libido and hair growth improved though. It took 3 weeks to recover from the crash though, and have been scared to ever supplement retinoids since. Ill only ever get amounts now via diet (eggs, butter, milk etc, ).

6 hours ago, ACCUiTy_drANE said:

Well, recently IBS has flared up so I have been trying to focus on that. I have also been dealing with anal fissures for some unknown reason (inflammation?). When my IBS was at its best, the main difference was that I was running frequently instead of lifting. So I have recently got back into running, which may have been more important to my health than I once appreciated. Anyway, right now I am taking all of the following:

Co Enzyme Q10
Maqui berry extract  thanks to dry eye syndrome catching up to me. (Surprise, surprise.)
Magnesium Citrate (Seemed to help my IBS in the past.)
Caffeine
Agmatine (Seemed to help my psychiatric symptoms in the past.)
Carnosine (Promotes telomerase activity and is capable of increasing the lifespan of mice significantly.)
PQQ (One post-Accutane user had good luck with this, and it seems capable of repairing damaged brain cells.)
Acetyl-l-Carnitine (Clears my head.)
Align probiotic
Citrucel fiber supplement

I am no longer taking Sarcosine, Tianeptine, or NAC. NAC aggravated IBS, Sarcosine made ED worse despite helping my mental functioning significantly, and Tianeptine has run its course. I do not want to be taking it forever. I am contemplating going back on low-dose Naltrexone as well. Essentially, I want to mimic whatever I was doing when my IBS was highly manageable. As a side note to anyone else reading this, Agmatine and LDN may help erection health as well.

Feeling brain-dead, impotent, and chronically bloated is not exactly useful for the dating world. It really seems to be a delicate balancing act to keep all three issues at bay. The antioxidants I take definitely help me feel more grounded. I still have trouble following conversations, and anhedonia creeps up at times. But I am way better than I once was. I will feel much better once I get my IBS back under control.

I wouldn't know where to start in this topic with so many posts, but I also feel brain dead, no libido, constant brain fog and anhedonia. Where would you recommend someone starts trying to improve this? It's been years.  I feel stupid and can't do ANYTHING anymore! I even have to keep reminding myself of my age.

11 hours ago, Gladiatoro said:

One poster went on 5 rounds of isotretinoin , and he is still breathing crazy world we live in.

I™m shocked and amazed at the same time btw he still has acne so my cure rate rating for isotretinoin should be more like 10 % vs 60.

I am very shocked by what some people do... if such repeated rounds are needed, that means tane is not working well in his case, and he keeps pushign it until the irreversible body damage is done. 

What kind of doctor can prescribe this 5 times? In soem countries, it is BANNED to do repeated, endless doses. 

Even worse, I've seen some take very logn term, or even permanent doses, claiming "acutane is natural" and they feel ok. I can't even imagine what kind of horrible side effects eventually will come. Even a single round has left some people permanently debilitated, imagine this. 

I understand if you have neuroblastoma, and your death is more likely than survival, you will take this drug whatever, but... 5 times for acne? 

I consider myself lucky as my body warned me earlier to reject this. This is not aspirine people. It is also not an antibiotic targeting certain bacteria, this drug possibly alters millions of gene expressions, cell divison, and more in every organ. 

3 hours ago, unbreakable1 said:

I wouldn't know where to start in this topic with so many posts, but I also feel brain dead, no libido, constant brain fog and anhedonia. Where would you recommend someone starts trying to improve this? It's been years.  I feel stupid and can't do ANYTHING anymore! I even have to keep reminding myself of my age.

Did your symptoms start on accutane or just after the dose? Have they changed at all? It seems terrible some have traded acne for lifelong disability of some sort. 

56 minutes ago, fiksi said:

I am very shocked by what some people do... if such repeated rounds are needed, that means tane is not working well in his case, and he keeps pushign it until the irreversible body damage is done.

What kind of doctor can prescribe this 5 times? In soem countries, it is BANNED to do repeated, endless doses.

Even worse, I've seen some take very logn term, or even permanent doses, claiming "acutane is natural" and they feel ok. I can't even imagine what kind of horrible side effects eventually will come. Even a single round has left some people permanently debilitated, imagine this.

I understand if you have neuroblastoma, and your death is more likely than survival, you will take this drug whatever, but... 5 times for acne?

I consider myself lucky as my body warned me earlier to reject this. This is not aspirine people. It is also not an antibiotic targeting certain bacteria, this drug possibly alters millions of gene expressions, cell divison, and more in every organ.
Did your symptoms start on accutane or just after the dose? Have they changed at all? It seems terrible some have traded acne for lifelong disability of some sort.

I can't be certain, but I went on Accutane for a few weeks when I was 14 (10 years ago) without getting to finish it, and then a full course when I was 18. It has definitely got worse over the past few years but started having depressive like symptoms when I was 14/15 which never went away. I came off it 6 years ago. I don't know if it's related to Accutane though.