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24 minutes ago, Colinboko said:Youre also in your 40sYou have to keep that in mind man.
You said there were no issues with weight gain when your side effects first started right?
In this instance age has nothing to do with platelets being below range.
In doing a google search, platelets can be affected by bone marrow and in looking at bone marrow aside from seeing that iron and zinc levels are important I also saw that ones Vit A levels are very important along with collagen - all these things contribute to healthy red blood cell formation apparently- I simply dont know enough. The reason I mentioned a virus in previous post was cause thats what the Dr said - a virus can effect platelet levels.
Regardless of blood results, who thinks they might have a collagen issue post tane??
Thin hair, thin skin, popping joints and stiff joints, eye floaters etc - collagen formation is either poor or non existent.
49 minutes ago, TrueJustice said:In this instance age has nothing to do with platelets being below range.In doing a google search, platelets can be affected by bone marrow and in looking at bone marrow aside from seeing that iron and zinc levels are important I also saw that ones Vit A levels are very important along with collagen - all these things contribute to healthy red blood cell formation apparently- I simply dont know enough. The reason I mentioned a virus in previous post was cause thats what the Dr said - a virus can effect platelet levels.
Regardless of blood results, who thinks they might have a collagen issue post tane??
Thin hair, thin skin, popping joints and stiff joints, eye floaters etc - collagen formation is either poor or non existent.
Sorry! Wasnt in regards to the platelets. Your pins and needles haha
1 hour ago, TrueJustice said:In this instance age has nothing to do with platelets being below range.In doing a google search, platelets can be affected by bone marrow and in looking at bone marrow aside from seeing that iron and zinc levels are important I also saw that ones Vit A levels are very important along with collagen - all these things contribute to healthy red blood cell formation apparently- I simply dont know enough. The reason I mentioned a virus in previous post was cause thats what the Dr said - a virus can effect platelet levels.
Regardless of blood results, who thinks they might have a collagen issue post tane??
Thin hair, thin skin, popping joints and stiff joints, eye floaters etc - collagen formation is either poor or non existent.
I should add, on report it says Red Blood Cell Morphology But no major abnormalities.
Im no expert but Im going to say Vit K supplementing is the cause here, I recently started dosing every day and might have been overdoing it....
I should have discussed this with Dr but only occurred to me once I came home and searched blood platelet lvls.
Note: Careful guys & girls with self diagnosing and supplementing - if Im correct about the Vit K Ill just stop using it, replace Vit K with something as powerful as say Finasteride and you could be in a world of trouble....lesson learnt.
ps I did a follow up blood test today so will get results in a few days.
9 hours ago, Gladiatoro said:Watch the documentary VAXXED and go to whale.to for vaccine information.The first step to Accutane recovery is accepting that you have been poisoned and damaged.
This is everything you need to know about whale.to https://rationalwiki.org/wiki/Whale.to
Well spotted on the test of Total Bile Acids, Thanks
6 hours ago, TrueJustice said:In this instance age has nothing to do with platelets being below range.In doing a google search, platelets can be affected by bone marrow and in looking at bone marrow aside from seeing that iron and zinc levels are important I also saw that ones Vit A levels are very important along with collagen - all these things contribute to healthy red blood cell formation apparently- I simply dont know enough. The reason I mentioned a virus in previous post was cause thats what the Dr said - a virus can effect platelet levels.
Regardless of blood results, who thinks they might have a collagen issue post tane??
Thin hair, thin skin, popping joints and stiff joints, eye floaters etc - collagen formation is either poor or non existent.
I would agree with the lack of collagen.
My skin doesn't heal properly, and is dry as a bone 7 years post accutane.
I've actually started to take cod liver oil for the vitamin A for the past 4 weeks and i am sure i'm seeing a slow improvement. I'd spent 7 years avoiding vitamin A so believe i'm probably deficient and really don't think i need to avoid it anymore. I've not noticed any negative affects what so ever, only positive. I am a hell of a lot hornier than before i started taking it too, however, take that with a pinch of salt and i never had any ED problems or anything.
41 minutes ago, Justdry said:I would agree with the lack of collagen.My skin doesn't heal properly, and is dry as a bone 7 years post accutane.
I've actually started to take cod liver oil for the vitamin A for the past 4 weeks and i am sure i'm seeing a slow improvement. I'd spent 7 years avoiding vitamin A so believe i'm probably deficient and really don't think i need to avoid it anymore. I've not noticed any negative affects what so ever, only positive. I am a hell of a lot hornier than before i started taking it too, however, take that with a pinch of salt and i never had any ED problems or anything.
Interesting - would you say, that you see an improvement with skin dryness? skin getting more oily again?
7 hours ago, TrueJustice said:Regardless of blood results, who thinks they might have a collagen issue post tane??
Thin hair, thin skin, popping joints and stiff joints, eye floaters etc - collagen formation is either poor or non existent.
Yes I would agree with your assumption. I have the same symptoms.
Retinoic acid =decreased Transketolase (thiamine deficiency)
Accutane inhibitshippocampal neurogenesis by using up the NADPH reducing cofactor... Thiamine
NADPH needed as a CYP26A cofactor for retinoic acid detoxification.
NADPH (B1) and FAD (B2) cofactors should be promoted.
Proteomic approach reveals novel targets for retinoic acid-mediated therapy of thyroid carcinoma.
Our previous studies demonstrated that retinoic acid (RA)-induced reduction of both, the key glycolytic enzyme ENO1 and proliferation-promoting c-Myc, resulted in decreased vitality and invasiveness of the follicular thyroid carcinoma cell lines FTC-133 and FTC-238. By employing two-dimensional electrophoresis and mass spectrometry, we identified proteins affected by RA treatment. In addition to previously reported decrease in ENO1 expression, we found that RA led to significantly reduced levels of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), pyruvate kinase isoenzymes M1/M2 (PKM1/M2), peptidyl-prolyl cis-trans isomerase A (PPIA), transketolase (TKT), annexin A2 (ANXA2), glutathione S-transferase P (GSTP1) and peroxiredoxin 2 (PRDX2) as compared to untreated control.
https://www.ncbi.nlm.nih.gov/pubmed/20538039
Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency.
Thiamine deficiency (TD) impairs hippocampal neurogenesis. However, the mechanisms involved are not identified. In this work, TD mouse model was generated using a thiamine-depleted diet at two time points, TD9 and TD14 for 9 and 14 days of TD respectively. The activities of pyruvate dehydrogenase (PDH), alpha-ketoglutamate dehydrogenase (KGDH), glucose-6-phosphate dehydrogenase (G6PD), and transketolase (TK), as well as on the contents of NADP(+) and NADPH were determined in whole mouse brain, isolated cortex, and hippocampus of TD mice model. The effects of TK silencing on the growth and migratory ability of cultured hippocampal progenitor cells (HPC), as well as on neuritogenesis of hippocampal neurons were explored. The results showed that TD specifically reduced TK activity in both cortex and hippocampus, without significantly affecting the activities of PDH, KGDH, and G6PD in TD9 and TD14 groups. The level of whole brain and hippocampal NADPH in TD14 group were significantly lower than that of control group. TK silencing significantly inhibited the proliferation, growth, and migratory abilities of cultured HPC, without affecting neuritogenesis of cultured hippocampal neurons. Taken together, these results demonstrate that decreased TK activity leads to pentose-phosphate pathway dysfunction and contributes to impaired hippocampal neurogenesis induced by TD. TK and pentose-phosphate pathway may be considered new targets to investigate hippocampal neurogenesis.
https://www.ncbi.nlm.nih.gov/pubmed/19686241
13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice.
Abstract
Use of the acne drug Accutane (13-cis retinoic acid, [13-cis RA]) has been associated with severe depression. This association has been considered controversial because no causative link has been found between 13-cis RA and this disorder. A recent hypothesis has suggested that atrophy of the hippocampus can result in depression. We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss. In humans this may be conjectured to be the mechanism by which Accutane contributes to depression.
also..
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On 12/20/2017 at 9:29 AM, TrueJustice said:Also of concern this time round was platelet levels 130 ( range 150 - 450 )
On 12/20/2017 at 1:24 PM, TrueJustice said:Im no expert but Im going to say Vit K supplementing is the cause here, I recently started dosing every day and might have been overdoing it....
This doesn't quite make sense to me. When's the last time you had this test?
This is a low platelets count. This sounds vitamin k antagonistic. For example warfarin (a vitamin k antagonist) would make this worse by thinning the blood and increasing risk of bleeding. Same with aspirin.
Vitamin K's most known basic function is to clot blood to prevent bleeding.
They are looking at vitamin k2 and vitamin D to actually raise platelets in those that could be considered preleukemia.
^Speaking of this i've noticed numerous mentioned synergies between vitamin D and k2. Vitamin D stimulates, while vitamin k regulates many functions. This would make sense when you consider how innate these processes are.
Vitamin K2 And Vitamin D3 Combination Therapy May Increase Red Blood Cell and Platelet Counts In Low-Risk MDS Patients
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If your concerned, which that test result is something to be concerned about in general, I would stop supplementing vitamin k2. I would also like to know about any follow up test regarding this and what your doctor thinks.
http://www.biolab.co.uk/index.php/cmsid__biolab_test/Vitamin_B1_(Thiamine)_-_transketolase_activity
if anyone is in the UK you can order this test.
@indigorush would be ironic if you were the one to get this test.
On 12/21/2017 at 7:50 AM, guitarman01 said:This doesn't quite make sense to me. When's the last time you had this test?
This is a low platelets count. This sounds vitamin k antagonistic. For example warfarin (a vitamin k antagonist) would make this worse by thinning the blood and increasing risk of bleeding. Same with aspirin.
Vitamin K's most known basic function is to clot blood to prevent bleeding.When you don't have enoughplateletsin your blood, your body cannot form clots. Alow plateletcount may also be called thrombocytopenia. This condition can range from mild to severe, depending on its underlying cause. For some, the symptoms can include severe bleeding and are possibly fatal if they're not treated.Feb 8, 2016They are looking at vitamin k2 and vitamin D to actually raise platelets in those that could be considered preleukemia.
^Speaking of this i've noticed numerous mentioned synergies between vitamin D and k2. Vitamin D stimulates, while vitamin k regulates many functions. This would make sense when you consider how innate these processes are.Vitamin K2 And Vitamin D3 Combination Therapy May Increase Red Blood Cell and Platelet Counts In Low-Risk MDS Patients
[Edited link out]
If your concerned, which that test result is something to be concerned about in general, I would stop supplementing vitamin k2. I would also like to know about any follow up test regarding this and what your doctor thinks.
Yes, my understanding is Vit K helps with clotting the blood, makes sense that someone who bleeds a lot would benefit from taking it.
My thought yesterday when thinking about this red cell morphology was that its just clumping of the blood....well see with follow up test. It also says platelets clumped on report, again my initial thought was too much Vit K causing a thickening of the blood....
I also have to point out I dont really know what the hell Im talking about medically speaking so it could be totally unrelated- could very well be virus related as suggested by Dr.
Ill keep you all posted.
On 2017-12-19 at 10:03 PM, ailaeshiz said:This is everything you need to know about whale.to https://rationalwiki.org/wiki/Whale.to
Wiki is a paid for web site in fact paid and bought by pharmaceutical companies , never trust wiki.
Whale.to has some of the best information availability anywhere FACT.
2 hours ago, TrueJustice said:Does anyone know if theres a medication for chronic inflammation?
The natural paths are easy to know - turmeric,juicing etc
Just curious if theres a prescription drug for it too?
hydrocortisone
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do we have any info on how or if tane affects bile?
53 minutes ago, pimple pimp said:hydrocortisone
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------do we have any info on how or if tane affects bile?
Is that a topical solution?
Im talking medication- tablets.
21 hours ago, TrueJustice said:My thought yesterday when thinking about this red cell morphology was that its just clumping of the blood....well see with follow up test. It also says platelets clumped on report, again my initial thought was too much Vit K causing a thickening of the blood....
Again, Im not so sure about this. Platelets clumping is also seen when blood is unable to clot on anticoagulant therapy . So clumping doesn't mean thickening of the blood. If your diagnosis was true, which hopefully not, it means quite the opposite.
Here is showing Vitamin K inhibiting platelets clumping.
Based on your age and what you are going through, Im not sure you are the best candidate to look at or realize some things. (This has nothing to do with vitamin k.)
One post its "lesson learned", the next post its "who can suggest me some good drugs for inflammation"
On the other hand maybe you are a good candidate because of your age. Your still getting tests and some things might start to show up where some of us could be a precursor of this.
Im asking the inflammation question because Dr immediately got me to do another blood test, One I dont think Ive ever had before for inflammation!!
Im just pre-empting if there is an inflammation issue what she might prescribe, if anything at all.
If she mentions turmeric etc, the answer will be no - as a group weve gone down this path, supplements etc are bullshit for a cure, we need to medicate!!
I take your point about K - I did also say I dont know for sure just yet.
I cant see her saying get on the Vit K supplements keep in mind I havent even mentioned Vit K to her at any stage yet.
5 hours ago, Gladiatoro said:Wiki is a paid for web site in fact paid and bought by pharmaceutical companies , never trust wiki.Whale.to has some of the best information availability anywhere FACT.
it's psuedoscience for nutters and the mentally deranged.
12 hours ago, pimple pimp said:hydrocortisone
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------do we have any info on how or if tane affects bile?
It definitely has an impact on bile flow, a lot of people have speculated on it inducing cholestasis. I'm currently taking UDCA which seems to help a lot here, but it doesn't improve any of my other symptoms.
I don't think there are any studies to prove this, but then there are few studies on the effects of the drugs. The ones there are have shown its proven to shorten telomeres which means you are at a much increased risk of degenerative conditions like Alzheimers, dementia, many cancers as a result of having taken the drug but that's of no surprise. I think a lot of people think that as the drug was initially designed to treat brain cancer that you're at an decreased risk of getting cancer, but the nature of the lasting effects would strongly indicate otherwise.
The 'NatureCrazy - 8 tips on accutane' video on youtube talks about cholestasis - worth searching for.
On 12/20/2017 at 10:31 AM, Roland1968 said:Interesting - would you say, that you see an improvement with skin dryness? skin getting more oily again?
The problem with answering this question is the fact that i neglected to moisturize or use face wash for about 6 years so my skin became increasingly dry over this period until I had scales and it was pretty much f'ed, I always blamed accutane for it but i think it's because of the poor skincare routine post accutane.
I now use a pH 5.5 soap free face wash, use starflower oil on my face at night and moisturizer during the day. I don't currently have any noticeable dryness but the damage left behind is almost crippling. My face still feels dry and tight after washing until i apply something to it but i darent leave it without moisturizer anymore so i'm not sure what it'd be like if i left it.
Adding Vitamin A in the form of cod liver oil to my routine is definitely helping to heal the skin barrier but i think this is just going to be a hell of a long process. My face looks and feels oily to the touch even late in the day now, but i'm not sure if that's the moisturizer or what. It used to be at it's driest at the end of the day.
I really do think that avoiding vitamin A for so many years is NOT the right thing to do - I've literally noticed no negative effects since taking cod liver oil and like i said in my previous post, this is the horniest i've felt in years but i don't know if that's a coincidence.
For the past year I had also developed a dry penis head - however, since taking cod liver oil it has started to go and isn't anywhere near as dry as it had gotten.
17 hours ago, TrueJustice said:I cant see her saying get on the Vit K supplements keep in mind I havent even mentioned Vit K to her at any stage yet.
At this point she's probably not going to know much about what's currently being researched as far as k2. Its very current and ongoing. Testing coagulation factors (vitamin k can be responsible for coagulation and anticoagulation) and Lupus anticoagulant might be of interest. (I just had a neurologist retest me for Lupus anticoagulant, still waiting on results) a rheumatologist would also order Lupus anticoagulant, not sure about a primary doctor.
When it comes to making connections with Accutane and what it might have induced, out of all the doctors i've seen they barely spend any time even considering this, so in this regard some of us are going to have much more extensive knowledge of what could be possible.
For example I've spent 20 years on this, Doctors spend a few minutes.
Anyone wondering my age btw im 34. I realize if there is some processes that continue to go in the wrong direction, the more critical the passage of time might become in figuring some things out.