What sucks is that my body feels like it is screaming out for hormones, yet my levels are normal, although I appear to have low cortisol, and getting that double checked.

I was seeing liberal anti ageing Dr years ago, took pregnenolone and HCG at very low doses and felt 50% better. I don't see him anymore as he charges a fortune. I feel worse OFF everything, yet my numbers in no way show hypogonadism.

It is very frustrating.

JULY 2017

FSH .....1.7IU/L . (1.5 - 9.7)
LH .....2.9IU/L . (1.8 - 9.2)
Estradiol.....60pmol/L . (<160)
Test total .....17.3 (12 - 31.9)
SHBG.....43nmol/l . (17 - 56)
Free Test .....306pmol/l
Progesterone .....1.0nmol/l . (0.7 - 4.3)

DHEAS .....5.6umol/l . (4.3 - 15.0)
Cortisol AM.....230nmol/L . (172 - 497)
ACTH.....4.3pmol/l , (1.6 - 13.9)

Thyroid
Free T4 .....13.2(11 - 21)
Free T3 .....4.6(3.2 - 6.4)
TSH .....2.26(0.5 - 5)

On 10/30/2017 at 9:47 AM, guitarman01 said:

You didnt finish the story and the most important takeaway.
[Edited link out]
This didnt work for him.
Now he's trying to combat a 5ar inhibitor effect with a 5ar promoter.
Or balance the two. If you go back and look he said inhibiting 5ar wasnt working long term
now since his last post, hes trying to balance the two and who knows where hes at. its only been a couple weeks.
He never followed up again.
I think your ultimately going to get yourself in more trouble with this.

Heres some test results from someone we all know on here. Hope he doesn't mind.
So, the best test results I've had in ten years and I am feeling worse than ever (particularly bad on the day the test was performed)

ACTH: 31 (7-50)pg/ml

Prolactin: 14.1 (2.8-29.9)ng/ml

LH: 2.8 (2.0-9.0)mIU/ml

FSH: 0.7 (0.9-15.0)mIU/mlL

Inhibin-A: 1 (<21)pg/ml

Cortisol: 20.4 (9-25)ug/dl

DHEAS: 523 (110-370)ug/dlH

17 OH-Progesterone: 90 (32-307)ng/dl

IGF-1: 207 (53-331)ng/ml Z-score = 0.7 (-2.0 to +2.0) (not sure what z-score is)

Total T: 729 (250-1100)ng/dl

Free T: 168.4 (35-155)pg/mlH

DHT: 63 (25-75)ng/dl

E2: 17 (6-54)pg/ml

Ah that's a shame, I didn't really read beyond the 'high dose zinc' part as that's a no-go for me.

Have you had potassium tested via a hair mineral analysis? If it's low on that, then you fit the (theoretical) profile of having down-regulated progesterone receptors (as oppose to up-regulated obviously).

6 hours ago, tanedout said:

Ah that's a shame, I didn't really read beyond the 'high dose zinc' part as that's a no-go for me.

Have you had potassium tested via a hair mineral analysis? If it's low on that, then you fit the (theoretical) profile of having down-regulated progesterone receptors (as oppose to up-regulated obviously).

Well now this is kind of saying the same thing (trying to manipulate DHT through 5ar regulation) except with a different hormone.
I havent found much information on the credibility of a hair mineral test, otherwise I prob would have gotten one already.

To put some perspectiveon whats been talked about on here recently,here is a post from a long time fin sufferer.
Im not trying to shoot down ideas, but offer more information so people are aware before making decisions.
This post is from this month.

http://www.propeciahelp.com/forum/viewtopic.php?f=5&t=11778
I have been made aware that some guys are experimenting with therapies based on Mifepristone (RU486, "Ella", etc.). Just one word of warning: Mifepristone is a potent anti-androgen (1). Long time users of this board may recall that many therapies which made people (initially) feel better were based on substances with anti-androgenic properties (including therapies based on Finasteride, Dutasteride, Zinc, etc.). I myself had a go with milk thistle (AR antagonist), and regret it to this day.

Even if Mifepristone may improve symptoms for a short period, the risk of exasperating the underlying PFS problem is huge. The result of which would then be a much more serious form of PFS than before the treatment. Even if the current situation is not good, please remember that misguided therapy attempts can always make the situation persistently worse (like in my case). When trying out therapies, I suggest to avoid anything that directly or indirectly interacts with the Androgen Receptor (only exception: TRT, preferably low dosed and IM).

(1) https://academic.oup.com/mend/article-l ... .2003-0189

You should be aware of this as well. Probably an isolated case. dont know the details, but still. Id want to know this.
http://www.nytimes.com/2004/11/16/health/fda-strengthens-warning-on-the-abortion-pill.html
WASHINGTON, Nov. 15 - The death of a California woman in January after she took an abortion pill prompted federal drug regulators on Monday to strengthen the warning label on the drug, RU-486, also known as mifepristone.

i'm up to 20-30mg a day of CBD oil and it is just amazing. You hold the oil under your tongue for 60 seconds and instantly relax, your anxiety dissipates, shoulders come down, thinking becomes clearer. And it's actually good for your body/brain. Amazing.

https://www.littlemountainhomeopathy.com/accutane-for-acne-side-effects-worth-the-risk
The article mentions homeopathy is used successfully for Accutane side effects.

For those who don't catch colds anymore! 

6 hours ago, Gladiatoro said:

https://www.littlemountainhomeopathy.com/accutane-for-acne-side-effects-worth-the-risk
The article mentions homeopathy is used successfully for Accutane side effects.

I was suggesting both Pituitary and Hypothalamus were affected after tane, its actually the Hippocampus as talked about in article!!!

I mean this cell death or hindrance they talk about, Surely this is playing a part in regulating our hormones??

They must of tested someone to even know that this can happen, has anyone discussed this issue with a neurologist or endocrinologist?

hey guys first of all I want to let you know that I'm still good and I feel my connection between my brain and my balls again. my size has become 100% normal last week and I'm so happy with that. But what I really want to tell you is that I have contact to a dr. who is a specialist in hormonal problems and I have explained to him what has happened. So yesterday I met him and we had a long conversation about the whole accutane pfs thing. I asked him how it could happen and he had a theory. It was very complicated and I didn't understand everything but I will sum it up. He said that before I took accutane I properly had high sensitive gonadotropin receptors which where the reason I had acne and was sexual overactive. Then I took an androgen blocker so my brain react in producing even more but my body can't use it the way it should so it builds new receptors and overload them with prohormons. Thats the reason my acne did get worse at the beginning of treatment. But at the long run overload receptors don't react more and more which results in death of cells(hes explanaition was hard to understand trust me) so my balls tried to produce testosteron but they can't because they had no stimulation. They began to hurt and shrunk and the body react with producing cortisol and estrogen. I asked why the cycle hasn't normalise natural and he said because the old blocked receptors do not function anymore because your body already has produced new ones and they don't "know" they had died from overload. To my recovery he said that he can't explain it 100% but in his opinion propecia tried to block the receptors who are already blocked or dead and by blocking the receptors the body react by building new receptors in healthy cells.

4 hours ago, idontknow1993 said:

hey guys first of all I want to let you know that I'm still good and I feel my connection between my brain and my balls again. my size has become 100% normal last week and I'm so happy with that. But what I really want to tell you is that I have contact to a dr. who is a specialist in hormonal problems and I have explained to him what has happened. So yesterday I met him and we had a long conversation about the whole accutane pfs thing. I asked him how it could happen and he had a theory. It was very complicated and I didn't understand everything but I will sum it up. He said that before I took accutane I properly had high sensitive gonadotropin receptors which where the reason I had acne and was sexual overactive. Then I took an androgen blocker so my brain react in producing even more but my body can't use it the way it should so it builds new receptors and overload them with prohormons. Thats the reason my acne did get worse at the beginning of treatment. But at the long run overload receptors don't react more and more which results in death of cells(hes explanaition was hard to understand trust me) so my balls tried to produce testosteron but they can't because they had no stimulation. They began to hurt and shrunk and the body react with producing cortisol and estrogen. I asked why the cycle hasn't normalise natural and he said because the old blocked receptors do not function anymore because your body already has produced new ones and they don't "know" they had died from overload. To my recovery he said that he can't explain it 100% but in his opinion propecia tried to block the receptors who are already blocked or dead and by blocking the receptors the body react by building new receptors in healthy cells.

So the new receptors are not affected from that overload before because my brain didn't produce much the last years. Now the brain reacts and can produce gonadotropin again because of the new healthy receptors. When I stopped the fin there was no blocker and the receptors weren't overloaded so they can function normally. I could write a lot more but my english is not very good. I hope this can help you. Btw. he told me to play with hormons this way is very risky espacially when your young and he said what helped me to recover could fuck somebody up very bad so he don't recommend to take finasterid when youre affected from accutane.

Thanks for posting, interesting to hear that is a doctors analysis of the situation, and again points towards receptors being altered.

That seems to make so much sense and obviously explains why hormone levels can be fine, yet people have symptoms of one or the other being high or low or whatever. I don;t think there is an accurate way to measure these changes unfortunately, so you rely on theories and experimentation.

I wish the cure was something more simple than finasteride! I guess it needs to be something powerful that acts on the same receptors that we've altered using accutane, and the fact these changes clearly don't normalise on their own means the changes are basically permanent otherwise.

I have a number of angles I want to explore down the herbal anti-progesterone route, but I'm not taking the option of maybe doing a 3-5 day cycle of 10mg finasteride off the table. Would be great to get some input from Dr Pezzi on this really, as he's the one that came up with that cure like 7-8 years ago, but I can understand he's probably a busy guy and doesnt have time to post on acne forums! At least it makes a lot more sense as to why it might work now.

On 10/30/2017 at 6:31 AM, macleod said:

um yes, me since summer.

-----------------------------in response to labs above, a few of my results

Prolactin

: 10.1 ng/mL

(4.0 - 15.2 ng/mL)

Cortisol	: 18.8 ug/dL (6.2 - 19.4 ug/dl) A.M.

ACTH: 61.4 pg/mL (7.2 - 63.3 pg/mL)

LH: 3.7 mIU/mL (1.7 - 8.6 mIU/mL)
FSH: 0.8 mIU/mL (1.5 - 12.4 mIU/mL)

interesting our LH, FSH, and Cortisol are similar. although our Labs "ranges" differ.

my T was very low (189-220) at one point, different from the person above. With TRT it's around the high 300's currently.

I find it really interesting both of our FSH are identically treading water. I talked to my endo about it, apparently there is no clinical way of raising it.

And, just to add, my stance is something neuro/hormonal as the culprit.

Remember Hans Peterson? Yes, he was only on the drug for FOUR days. He immediately went impotent and gradually turned manic/depressed. Not nearly enough time to "damage the liver." Not enough time for "chronic cell dehydrogenase". Think about it.

very good point. Crank on lasting sides only tool for 10 days and suffered a crash. No better today.

7 hours ago, idontknow1993 said:

hey guys first of all I want to let you know that I'm still good and I feel my connection between my brain and my balls again. my size has become 100% normal last week and I'm so happy with that. But what I really want to tell you is that I have contact to a dr. who is a specialist in hormonal problems and I have explained to him what has happened. So yesterday I met him and we had a long conversation about the whole accutane pfs thing. I asked him how it could happen and he had a theory. It was very complicated and I didn't understand everything but I will sum it up. He said that before I took accutane I properly had high sensitive gonadotropin receptors which where the reason I had acne and was sexual overactive. Then I took an androgen blocker so my brain react in producing even more but my body can't use it the way it should so it builds new receptors and overload them with prohormons. Thats the reason my acne did get worse at the beginning of treatment. But at the long run overload receptors don't react more and more which results in death of cells(hes explanaition was hard to understand trust me) so my balls tried to produce testosteron but they can't because they had no stimulation. They began to hurt and shrunk and the body react with producing cortisol and estrogen. I asked why the cycle hasn't normalise natural and he said because the old blocked receptors do not function anymore because your body already has produced new ones and they don't "know" they had died from overload. To my recovery he said that he can't explain it 100% but in his opinion propecia tried to block the receptors who are already blocked or dead and by blocking the receptors the body react by building new receptors in healthy cells.

So the new receptors are not affected from that overload before because my brain didn't produce much the last years. Now the brain reacts and can produce gonadotropin again because of the new healthy receptors. When I stopped the fin there was no blocker and the receptors weren't overloaded so they can function normally. I could write a lot more but my english is not very good. I hope this can help you. Btw. he told me to play with hormons this way is very risky espacially when your young and he said what helped me to recover could fuck somebody up very bad so he don't recommend to take finasterid when youre affected from accutane.

Hi, are you able to share the doctor's name by PM.We have doctors that are aware of PFS and work towards finding a cure but we don't have any doctors for post accuatane problems. If he understands it at all or has a strong opinions on it he would be a great contact for Rxisk.

Low FSH and LH are not a good sign and indicates possible fertility problems.
The regulators assure me that fertility is not affected but the question I have been asking them is - did they
ever test sperm on a guy who claimed to have sexual dysfunction.

If any of you guys feel like you can handle bad news regarding this matter please insist on sperm test.
If you live in the UK, I imagine you could get this test at a push. Especially if you say it is causing you mental anguish.

I suspect many of you don't care about this but we really do need to learn more about the damage accutane does.

For sure women have claimed that accutane caused them to have all sorts of womb problems including infertility.

On 10/31/2017 at 11:12 PM, tanedout said:

Thanks for posting, interesting to hear that is a doctors analysis of the situation, and again points towards receptors being altered. 

That seems to make so much sense and obviously explains why hormone levels can be fine, yet people have symptoms of one or the other being high or low or whatever. I don;t think there is an accurate way to measure these changes unfortunately, so you rely on theories and experimentation.

I wish the cure was something more simple than finasteride! I guess it needs to be something powerful that acts on the same receptors that we've altered using accutane, and the fact these changes clearly don't normalise on their own means the changes are basically permanent otherwise.

I have a number of angles I want to explore down the herbal anti-progesterone route, but I'm not taking the option of maybe doing a 3-5 day cycle of 10mg finasteride off the table. Would be great to get some input from Dr Pezzi on this really, as he's the one that came up with that cure like 7-8 years ago, but I can understand he's probably a busy guy and doesnt have time to post on acne forums! At least it makes a lot more sense as to why it might work now.

 

So I was in contact with Dr Pezzi a while back (couple of months).
I dont want to discourage anyone but this is what he said:

As for me im doubting between Fin and Ella
I think the key here is doing short cycles, like a  couple of days. If you do the long cycle you will get the same effects as long accutane usage
 

Kevin Pezzi, MD <removed>	Feb 10

On 11/1/2017 at 2:40 AM, hatetane said:

Hi, are you able to share the doctor's name by PM.We have doctors that are aware of PFS and work towards finding a cure but we don't have any doctors for post accuatane problems. If he understands it at all or has a strong opinions on it he would be a great contact for Rxisk.
 

Low FSH and LH are not a good sign and indicates possible fertility problems.
The regulators assure me that fertility is not affected but the question I have been asking them is - did they
ever test sperm on a guy who claimed to have sexual dysfunction.

If any of you guys feel like you can handle bad news regarding this matter please insist on sperm test.
If you live in the UK, I imagine you could get this test at a push. Especially if you say it is causing you mental anguish.

I suspect many of you don't care about this but we really do need to learn more about the damage accutane does.

For sure women have claimed that accutane caused them to have all sorts of womb problems including infertility.

Gonadotropins are glycoprotein polypeptide hormones secreted by gonadotrope cells of the anterior pituitary of vertebrates.[1][2][3] This family includes the mammalian hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), and placental/chorionic gonadotropins human chorionic gonadotropin(hCG) and equine chorionic gonadotropin (eCG),[4] as well as at least two forms of fish gonadotropins

29 minutes ago, Walden Rev said:

Hi Walden,

Yes, I did, and the effects were amazing for a while,
but in retrospect, considering the years of negative effects secondary to finasteride (Propecia),
I wouldn't do it again because there are other ways to restore sensation (they do nothing for size, but there are other ways to address that).

Hi Walden,

I've been swamped at work but I will save your message and respond to the group as soon as I can. Bottom line: there is hope.

I remember when you posted that - unfortunately he leaves it on a bit of a cliff-hanger. Would've been good if he could've expanded further on what he seems to indicate might be alternative solutions.

8 hours ago, tanedout said:

I remember when you posted that - unfortunately he leaves it on a bit of a cliff-hanger. Would've been good if he could've expanded further on what he seems to indicate might be alternative solutions.

Yeah, im trying to get in touch again, maybe the fin story will spark his interests again

Heres an idea for any budding chemist or anyone wanting to win that $100,000, create a drug that works like fin minus the negative side effects!!

Who knows, maybe people are scrolling through these pages looking for ideas - youd have to be in the right ball park with looking at how finasteride works surely???!!!

just eliminate the nasty part of the drug....

14 hours ago, hatetane said:

Hi, are you able to share the doctor's name by PM.We have doctors that are aware of PFS and work towards finding a cure but we don't have any doctors for post accuatane problems. If he understands it at all or has a strong opinions on it he would be a great contact for Rxisk.

Low FSH and LH are not a good sign and indicates possible fertility problems.
The regulators assure me that fertility is not affected but the question I have been asking them is - did they
ever test sperm on a guy who claimed to have sexual dysfunction.

If any of you guys feel like you can handle bad news regarding this matter please insist on sperm test.
If you live in the UK, I imagine you could get this test at a push. Especially if you say it is causing you mental anguish.

I suspect many of you don't care about this but we really do need to learn more about the damage accutane does.

For sure women have claimed that accutane caused them to have all sorts of womb problems including infertility.

The guy has retired already it was a friendly servce of him as I didn't even pay him at all. I honestly don't think he's interested in that but I will ask him. Florgot to mention that

Joint Pain... has anyone tried xanthine inhibitors?

Allopurinol

Gout and vitamin A intoxication: is there a connection?

Isotretinoin use for acne vulgaris is associated with increased serum uric acid levels.

Hey Guys,

Regarding taking 5AR Inhibitor this is not a good idea in the long run.

@tryingtohelp2014

You are spot on about xanthine oxidase (in my theory) although this is one piece of the puzzle .

To understand my point see the Network Diagram which i posted in the following link (see Xanthine Oxidase on top right) :

http://forums.phoenixrising.me/index.php?threads/lxr-liver-x-receptor-inhibition-as-a-root-cause-of-me-cfs.54552/#post-910111

We may have some good news soon, will post about this shortly

Mariovitali:

With all thats been said over last couple of pages in regard to hormone and receptors, do you still think we should be looking at the Liver??

@mariovitaliA few questions for you.
Would you say you are most active on phoenix rising as opposed to websites that deal with pfs?
Do you more so associate your condition with CFS than PFS? If the answer is yes to both of these questions, what would be the reasoning?
Is it because CFS is a more medically recognized condition atm?
Are you a member of propeciahelp? Have you or do you keep in contact with some of the long time members?
For example "awor" a long time founding member who also appears to be recognizing the similarities.
http://www.propeciahelp.com/forum/viewtopic.php?f=26&t=11773
I have reason to believe that the persistent side effects arising from:

• 5ARIs (finasteride, saw palmetto, dutasteride)
• 13-cis-retinoic acid (Accutande, etc.)
• Various Antidepressants
• GnRH Analogs (Lupron, etc.)

are related in terms of a common molecular mechanism.

Lot of questions. Last one. Is it safe to say there is a pretty big population that isnt at all affected by propecia side effects?
Thanks.

Hey guys I just wanted to update.
I'm the guy who has been eating 2 avocados a day to inhibit 5ar inhibitor enzyme.

It has been some weeks since I last posted and I am happy to say that, since the last time I posted, my condition has again become slightly better. My biggest issue is still refreshing sleep. Currently I can only consistently get 3-4 hours of decent sleep a night, usually followed by another 5-6 hours of restless sleep. Some days are better than others along with some weeks being better than others, this is actually true for all of my symptoms. But progressively, everything still seems to be going uphill.

For example I have had some days that are so good, so full of the zest of life, that I actually became a little sad, sad because I realized I hadn't felt so good since high school (when I started taking accutane). I thought that I had just got older and had less emotions and interests and that was part of getting older (and maybe it is to an extent, I'm not even quite 21 yet though so I wouldn't completely know). But still, I'm happy. A couple months ago the only emotions I knew were pain, anxiety, and anguish. Big improvement in my books.

Anyway, I have also reduced avocado consumption down to 1 a day and added a tablespoon of hempseed oil to my regimen - Just a note.

@mariovitali
Although the tools and methods you are using to research our conditions are currently beyond me, I do understand there power. And I do have a question if you are kind enough to answer.
Do you believe consuming common foods that are known 5ar inhibitors would be bad in the long run? Mostly I known a lot of green vegetables and certain plant oils can be mild to moderate 5ar inhibitors. I know enough about biology to known that it can get very nuanced and I am thinking that not all 5ar inhibitors are the same. However, I am only theorizing this because I have read a good amount of peoples stories who have claimed to recover to normality through different kinds of raw vegan type diets. Diets that probably had some 5ar inhibiting effect. Sometimes these diets are even all they claim to have done to recover to normality. So, my reasoning might be reasonable but not all that scientific.

http://www.propeciahelp.com/forum/viewtopic.php?t=6144

interesting thread.. this poor guy was getting so much testing done and was finding so much out and no one was giving him the time of day.

I personally believe I'm in the high estrogen boat as well. I have gained so much god damn weight, my hair and face have ridiculously low porosity

@TrueJustice

I cannot possibly know for sure. I also had high E2 and Low testosterone. At some point i was injecting Gonadotropin to have my Testosterone levels back in the normal range. It did help but the problem was that i was not looking at the root of the problem. I also tried small doses of E2 antagonists. They did help but short-term. Others who took large doses of E2 antagonists got screwed up big time so please be careful.

I believe that E2 is high either because of HPA Axis dysregulation and / or because of oxidative stress. But there is lot more going.

Please read the following excerpts below from this paper : https://www.nature.com/articles/nri.2016.62

This is exactly what i think is happening to us. The paper disucsses about Liver Injury from Viral infection but this is what i think has happened : A liver injury that then has affected many pathways setting our bodies to a vicious cycle that must be stopped. And this is so damn difficult because you do not have single point of failure but many pathways that need to be effectively supported. Those few individuals who make it (=snap out of PFS/CFS etc) are lucky because they do not have many problems in these pathways.

But i do believe that whatever happened is reversible for most of us, given the correct combination of supporting the pathways. And the younger you are the better the chances.

@guitarman01

Yes i spend more of my time to CFS sites because there is more active Research. Last week i have made it to connecting with Janet Dafoe the wife of Professor Ron Davis at Stanford. He is interested to what the algorithm is finding so perhaps we have some good news from there in the sense that someone might listen to this and test the Theory out.

The other person who listened is David Healy at rxisk.org. The Post-Finasteride Foundation did not listen and so i stopped having any interaction with them.

I do keep in contact with some old members. I talk to moonman who also forwards my posts to a guy called Droit and to another guy who became symptom-free using Tudca. Actually it was Droit that first suggested that PFS is some kind of CFS. But unfortunately i cannot be possibly active to all sites.

Will you have a Fibroscan at some point @guitarman01 ? I am also assuming that you are following the Thread you started on Phoenix Rising and there are more people making a possible connection between Accutane use and CFS. This is what i was hoping and Thank you for this post. We must raise awareness.

On 31-10-2017 at 1:37 PM, idontknow1993 said:

hey guys first of all I want to let you know that I'm still good and I feel my connection between my brain and my balls again. my size has become 100% normal last week and I'm so happy with that. But what I really want to tell you is that I have contact to a dr. who is a specialist in hormonal problems and I have explained to him what has happened. So yesterday I met him and we had a long conversation about the whole accutane pfs thing. I asked him how it could happen and he had a theory. It was very complicated and I didn't understand everything but I will sum it up. He said that before I took accutane I properly had high sensitive gonadotropin receptors which where the reason I had acne and was sexual overactive. Then I took an androgen blocker so my brain react in producing even more but my body can't use it the way it should so it builds new receptors and overload them with prohormons. Thats the reason my acne did get worse at the beginning of treatment. But at the long run overload receptors don't react more and more which results in death of cells(hes explanaition was hard to understand trust me) so my balls tried to produce testosteron but they can't because they had no stimulation. They began to hurt and shrunk and the body react with producing cortisol and estrogen. I asked why the cycle hasn't normalise natural and he said because the old blocked receptors do not function anymore because your body already has produced new ones and they don't "know" they had died from overload. To my recovery he said that he can't explain it 100% but in his opinion propecia tried to block the receptors who are already blocked or dead and by blocking the receptors the body react by building new receptors in healthy cells.

So the new receptors are not affected from that overload before because my brain didn't produce much the last years. Now the brain reacts and can produce gonadotropin again because of the new healthy receptors. When I stopped the fin there was no blocker and the receptors weren't overloaded so they can function normally. I could write a lot more but my english is not very good. I hope this can help you. Btw. he told me to play with hormons this way is very risky espacially when your young and he said what helped me to recover could fuck somebody up very bad so he don't recommend to take finasterid when youre affected from accutane.

Please keep us updated, how do you feel nowadays

@mariovitali
Im not spending alot of time on this atm because you can only look at so many studies before finding out for yourself what might be possible.
I too believe this could be time sensitive, meaning once you reach a certain age, you might not be able to go back and correct some things so easily. One example being peak growth is achieved between the ages of 15-20. Its also a prime age for acne and accutane prescriptions. If your more on the back side of this you might be better off then being on the front side.

There are possibilities though. Ive seen more than just whats below as far as possibilities.
When talking about xenobiotic processing, this doesnt take place in just the liver but the GI tract as well. It could also take place in the lymphatic system, the skin. It could be systemic. Xenobiotics also dont have to be drugs, but anything the body considers a threat or imbalance.

• Cytochrome P450-modifying agentsCytochrome P450-modifying agents: In vitro, vitamin K2 was shown to dose-dependently activate and directly bind to the SXR receptor, which regulates drug clearance in the liver and intestine, and to induce expression of the SXR target gene, CYP3A4, in osteosarcoma cell lines (105).