6 hours ago, Fchawk said:

Seven months ago I made a post describing the cause of accutanes symptoms and how to cure them. I started it 4 months before I made that post, so it had been nearly a year. I stand by my cure and statements, I fully believe I am cured, though thats not to say its left it scars. I also feel I am ready to move on with my life, which I was far from being able to do 12 months ago, and I am optimistic about my future, as I feel I might well live past 90 with mind and body intact, whereas not so long ago I felt I would be lucky to make 70, even if I did everything right

What do we know about accutane? Well certainly the people that make it claim to know so little it is scary. All they claim to know is that it causes birth defects, and it somehow causes acne to go away. They also claim it causes no lasting side effects, except the magical disappearance of acne. However, that is because not everyone suffers the same side effects, though the loss of acne is the most common one. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy(brain cell death), which results in varying degrees of brain damage. Below or the studies that prove this, further down is how to fix it, which is very possible with the right knowledge
 
http://www.ncbi.nlm.nih.gov/pubmed/25689814
"A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)."
 
http://www.ncbi.nlm.nih.gov/pubmed/15863802
 
"RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. 
Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning."

 œA 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.
 
http://www.ncbi.nlm.nih.gov/pubmed/15251924
œWe now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/
"This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA."
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/#R173
"Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression."
"In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage."
 
https://www.ncbi.nlm.nih.gov/pubmed/20708044
"13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice."
 
Now that we have established that Accutane causes hippocampal atrophy and varying degrees of brain damahe, what are the consequences?
 
Traumatic brain injury: a disease process, not an event.
https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/
œTraumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.
 
Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge
 
https://www.ncbi.nlm.nih.gov/pubmed/16425236
œThe hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.

 
In this we see that accutane, in many ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane™s sides. That is because they DO help. 
Now we established that hippocampal atrophy may be the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally, though if you wish to use antidepressants as well that fine as well
 

Nutritional treatment for acute and chronic traumatic brain injury patients.
https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related
"omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a a TBI"
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/
Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least.
 
http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/
Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well.
http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/
 
Long-term effects of a ketogenic diet in obese patients
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
 
"Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania"
 
Currently I  doing:
Creatine - increases Dihydrotestosterone (DHT) and testosterone. Increases muscle power and ALSO improves neuroplasticity
Fish Oil - improves joint pain, helps heart disease, and ALSO improves neuroplasticity 
Zinc - increases levels of male hormones and ALSO improves neuroplasticity
Magnesium - helps with chronic pain, fatigue and insomnia and ALSO neuroplasticity
Vitamin D: Improves bone health, physical fitness, and ALSO improves neuroplasticity

    CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity
Multivitamin - makes me less likely to be malnourished. 
I try to do meditation regularly, but I don't prioritise it enough... Though it helps with anxiety and stress, as well as neuroplasticity, and i plan to add it into my daily routine.  
I feel much better than I have in years. I think for the last two months I have woken with morning wood 95% of the time, social anxiety is limited, confidence in my abilities in much higher, and motivation to reach my goals, and also willingness to do the work to reach them, is also one of the main things I have noticed. Before I did the work still expecting to fail, while now I do the work and I expect success, which makes me actually enjoy the work, and that™s just one example. My life and my future doesn™t seem so hopeless, there is plenty to celebrate and I™m sure plenty I will celebrate in the future
 
Things I plan to do:
Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and ALSO improves neuroplasticity
Ketogenic Diet: Improves body composition, can help ED, and ALSO improves neuroplasticity
I try to do meditation regularly, but I don't prioritise it enough... Though it helps with anxiety and stress, as well as neuroplasticity, and i plan to add it into my daily routine.  

Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help
 
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121947/
 
The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation.
https://www.ncbi.nlm.nih.gov/pubmed/18173322
œHigh-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.
 
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory.
https://www.ncbi.nlm.nih.gov/pubmed/21940440
œDeep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.
 
Nootropic agents stimulate neurogenesis. 
https://www.ncbi.nlm.nih.gov/pubmed/19441945
 
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/
 
Acupuncture stimulation induces neurogenesis in adult brain.
https://www.ncbi.nlm.nih.gov/pubmed/24215918

Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/

    "A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17].

Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.
https://www.ncbi.nlm.nih.gov/pubmed/14695924
COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time.  
 
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/
 
œIn animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients™ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs”both the trauma-exposed and unexposed members”had significantly smaller hippocampi than non-PTSD pairs.
 
here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/
The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or the worse his mental state before the injury happened the worse his recovery will be, rather than being optimistic improves outcomes

If you try this accutane rehab routine, post in https://www.acne.org/messageboard/topic/366988-curing-the-long-term-side-effects-of-accutane-both-mental-and-physical/#comment-3554261, because it would be nice to have a forum filled with what will be hope and recovery, instead of regret, pain and despair

Remember, it will leave scars, but after this cure you will no longer be trying to cure the whole brain fog, depression, anxiety, injury-susceptible, erection dysfunction, and the continuous and inevitable deterioration of health that the doctors can't seem to pinpoint the cause of, and instead it will be merely the scars, such as back pain, eye floaters, the occasional sore joint, low T, and unlike before, your body will be able to respond and heal so even those scars may fade a little. Good Luck everyone, I hope you all read this because I am no longer going to preach it. This is the cure that will put hope back into your lives, and personally I feel this phase of my life is over. I keep going back to this forum and I see some different names and the familiar names, and I notice former regular posters are missing. Maybe some of them have given up, mentally or totally, and thats why they are no longer posting, but I hope that the reason they are no longer posting is the same reason I'm not posting, and that is because while Accutane has nearly ended me in the past, due to my research and the positive effects of it I no longer feel accutane is a massive part of my life, nor that it is going to be a significant factor in my future, and so I can finally get on with my life. 

Many thanks for  sharing and for all your obvious hard work. You claim a cure, you present scientific info and you present a protocol.
You would think at least 1 person would want to try this out. As much as I want you to stick around I think you owe it to yourself to move on.
Having said that it would be amazing if you could do a youtube video talking about your experience and warning many young people of the dangers of accutane especially re sexual health because there are no videos  out there other than Accuity that talk about this.
Indigo is right - there is no shame anywhere on this forum. The shame is on the makers of accutane and anyone who prescribes it!
The way to get back at roche is to warn others of the dangers and thereby  reducing their sales.
roche will never willingly protect young people from this drug so we have to do what we can to make sure everyone is rightly informed.
The repercussions of accutane are just too painful and devastating. We owe it to all victims past, present and future and especially for the young people who have already lost their lives and their parents to speak out and report side effects.

I also remind everyone that Rxisk need donations so please spread the word and donate if you can.
 

My blood pressure is high! I'm confused... aren't most of you guys in the low blood pressure boat? I've never had high blood pressure in my life until now

Hey guys,
today I stopped taking finasteride and now I want to see what happens. After 25 days I think it is better for me to stop. Some very weird things are going on and I have the same feeling I had when was on Accutane. These disgusting drugs are causing hell on earth and I hope they take them of the market soon. I have acne on my back from fin! How can this happen as I have got no changes in Libido ED problems? I will now wait and see if I get improvement. If not I will maybe do another cycle or if anyone has pther theorys that might be risky just tell me and I try. Cant get any worse at this point and I dont care

http://www.longecity.org/forum/topic/75083-what-are-the-effects-of-accutane-on-the-brain-and-is-it-reversible/

18 minutes ago, idontknow1993 said:

Hey guys,
today I stopped taking finasteride and now I want to see what happens. After 25 days I think it is better for me to stop. Some very weird things are going on and I have the same feeling I had when was on Accutane. These disgusting drugs are causing hell on earth and I hope they take them of the market soon. I have acne on my back from fin! How can this happen as I have got no changes in Libido ED problems? I will now wait and see if I get improvement. If not I will maybe do another cycle or if anyone has pther theorys that might be risky just tell me and I try. Cant get any worse at this point and I dont care

Interested to see your results. Keep us updated

13 hours ago, guitarman01 said:

@Fchawk
Im not sure if Traumatic Brain Injury would be the right term.
This would be similar to getting hit in the head with a baseball bat, or suffering a heavy blow to the head.
One minute your fine, the next your not. Its very sudden. Although people are sometimes not aware that it has happened.
Some of this could be measured with a MRI, in the case with NFL players and CTE not until post mortem.
Although it looks like there is a new advance scan that might. https://www.scientificamerican.com/article/study-finds-evidence-of-brain-injury-in-living-nfl-veterans/

Some of the advice and treatment could be similar. Could be. It could be the wrong thing as well. SSRI victims appear they are in a similar boat to post-accutane people . And look at what it might involve? Steroid genesis.
You cant argue with some of the studies specific to Isotretinoin, but then again its not that specific,

Resveratrol improveshippocampalatrophy in chronic fatigue mice by enhancing neurogenesisand inhibiting apoptosis of granular cells. ... Neuroimaging evidence showed structural and/or functional abnormalities existing in the central nervous system, especially thehippocampus, inchronic fatigue syndrome(CFS) patients.

Resveratrol improves hippocampal atrophy in chronic fatigue mice by ...

https://www.ncbi.nlm.nih.gov/pubmed/21372384

(and im not talking about taking Resveratrol, im talking about the disease process.)

Its good though to have some of these studies handy to print out to make ground when in front of any doctor and try to put it all together.
Thanks.

This could be the case with many drugs affecting hormone levels, and not just drugs but certain nutrients in excess amount. So whats happened to have this persist post treatment?
Its a check and balance process.

BACKGROUND: Two published casestudieshave reported SRI/SNRI-associated lowtestosterone levels. ... As decreasedtestosteronehas several negative health effects, we conducted a pilotstudyinvestigating the effect of fluoxetine treatment ontestosterone levels.

Fluoxetine treatment and testosterone levels. - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/16517449

When you suffer a TBI, the consequences are often delayed. With those NFL players usually they finish their career and are fine for a while, and often it is not not until well after retirement that those NFL players begin to suffer the more deleterious effects of brain damage, such as memory problems, depression, mood swings, endorconology problems etc.
The fact is that Accutane causes brain damage, and is scientifically proven to do so. It obviously doesn't do it by hitting you over the head, but it regulates chemicals in your body differently, changes your brain metabolism, and these effects last long after you stop taking it. My post has ALL the research and proof, and how to fix it. At the same time only one or two people have bothered to try it, even though it is 100% risk free, and would also cost less than $100 from your local chemist and doesn't require a prescription or anything. Here we have people saying take these tests, try to on these prescription drugs or steroids, etc, of which there are much larger risks and the people who have taken them are often only temporarily better and deteriorate after they stop taking them or have to keep taking them and they are still not satisfied with the results in the long term, as their body adapts to it or whatever.
In the last page I have someone who is trying out finistrade, which causes symptoms like ours but much more focused on the DHT/Hypothalamicpituitaryadrenal axis side of things, while DHT is only a part of the Accutane side effects. He is taking a much larger risk than my treatment, but if it helps him, it may be worth it. I tried a vitamin A treatment before I tried my current one, and it didn't work at all and I regret doing it, because it postponed my recovery a bit, but I guess in Edisonesque fashion I simply found another way to not cure Post Retinoid Sexual Dysfunction, and knowing that that was not the way helped me on my way to actually finding something that worked, and it also taught me to have a much stronger grounding in research before I made a diagnosis of what was causing my symptoms and what the way to get better would be. I guess at this stage I am frustrated that despite having spent over a thousand of hours doing research and now I have found a risk free, cheap accessible cure, which is the thing everyone seems to be searching for, it is just being ignored, and even though I have every step from diagnosis to recovery strongly grounded in research and studies people are still much more willing to take much greater risks that have no scientific backing or give up!!

Sure its not a pill you can just take and you will feel like your old self right away, it will take a few months before you get from 50% to 90%+, but most rehabilitation isn't as swift as the injury. You can hurt your back in a moment, and it can take months of physical therapy to rehab it, and so Accutane can do its damage quickly, and it will take several months of following the rehab to recover. Instead of looking for a magic pill that will fix it, and bemoaning the injustice that such a significant amount of damage was dealt to you for doing something that seemed trivial and most people do without consequence, just do the damn rehab and get rid of the back pain so you can get on with your life!

Fchawk - I'm not sure there's anything in your protocol that we haven't already tried in terms of supplements? Everything listed there I'm either still on or have tried...

I totally understand your theory about TBI, the only thing I can think that might have given you some advantage is the meditation which you'd have to do daily, I use to do yoga daily that included meditation but no lasting results I'm sorry to say.

Have you done any of the hyperbaric stuff or deep brain stimulation??

No need for more science, totally believe the TBI theory with Roaccutane.

12 hours ago, tanedout said:

L-dopa doesn't work long term unfortunately, you build a tolerance to it quite quickly and it becomes ineffective. Best to keep it for the odd day when you want a dopamine boost!

But you're on about a 'normal' person.. our bodies are out of balance post accutane, so many studies are likely not be relevant to us, one thing that makes this situation so hard to find answers for.

If you do I would suggest taking zinc supplements as you come off the clomid (just based on what the PFS guys are saying)

You are definitely talking about the prescription stuff and not supplements like herbs and L-tyrosine right?

People requiring TRT are also out of balance to extent , else they would not require it.

Regardless of what theory you subscribe to, one should always establish a clear deficiency via testing before starting any hormone. This seems to be absent with progesterone?

1 hour ago, TrueJustice said:

Fchawk - I'm not sure there's anything in your protocol that we haven't already tried in terms of supplements? Everything listed there I'm either still on or have tried...

I totally understand your theory about TBI, the only thing I can think that might have given you some advantage is the meditation which you'd have to do daily, I use to do yoga daily that included meditation but no lasting results I'm sorry to say.

Have you done any of the hyperbaric stuff or deep brain stimulation??

No need for more science, totally believe the TBI theory with Roaccutane.

Didn't know any of you had tried it, as I haven't seen anyone mentioning taking creatine, fish oil, zinc, etc on a regular basis. I haven't tried hyperbaric stuff, although I am sure it would help and probably would do it if it was easily accessible/inexpensive, and I also haven't tried the deep brain stimulation, though I haven't looked into it enough to know whether I would do it even if I could right away. At the same time I feel I am better so I am not pushing too hard to try more things

TBI is not something we experience with Accutane.
If we experience altered brain metabolism or even damage, it isn't va TBI.
TBI is just one specific type of brain injury that occurs from external physical force trauma. There are many different types of ways the brain can be injured.

Hi Everyone

I was optimistic when I found this post from 6 years ago that by now there would be a miracle cure to my problems wishful thinking J

When I was 15 I was put onto Roaccutane to cure my cystic acne. My skin got much much worse, though eventually the cysts did go, but I still have acne today and Im now 28. I can live with that - by now Ive accepted that my spots are part of me. But like everyone else here, its the long lasting side effects I struggle with. A few years ago I saw 3 different doctors and tried to explain how Roaccutane was still affecting me today and they all dismissed me, telling me that that was impossible.

Today I still suffer from depression - I can be fine one day and the next I will be crying my eyes out for no real reason. Occasionally I have suicidal thoughts too.

I also have very light sensitive eyes - I have to have sunglasses with me at all times just in case. The other night I was having dinner out and the light nearby was quite bright - I had tears rolling down my cheeks because my eyes couldnt cope - so annoying!!

But for me the worst side effect I still have is joint / muscle pain. I have terrible knee pain to the point where I yell out in pain sometimes when my legs have been in a certain position for a while. It feels like my knees are going to snap. Stairs hurt my knees. Cycling hurts my knees. Workouts hurt my knees. Gardening REALLY hurts my knees! I am a fit person so this is very limiting / frustrating for me. I also have what I have always called Roaccutane pain in my lower back - if Ive been working a manual task like I was yesterday, the pain is so bad it almost hurts to breathe. This can sometimes occur without reason too, just by lying down, where I have to take very shallow breaths to control the pain.

Im at a loss as to what to do. The side effects should have disappeared 12 years ago yet here they still are, showing no signs of disappearing any time soon.

57 minutes ago, Fchawk said:

2 hours ago, TrueJustice said:

Fchawk - I'm not sure there's anything in your protocol that we haven't already tried in terms of supplements? Everything listed there I'm either still on or have tried...

I totally understand your theory about TBI, the only thing I can think that might have given you some advantage is the meditation which you'd have to do daily, I use to do yoga daily that included meditation but no lasting results I'm sorry to say.

Have you done any of the hyperbaric stuff or deep brain stimulation??

No need for more science, totally believe the TBI theory with Roaccutane.

Didn't know any of you had tried it, as I haven't seen anyone mentioning taking creatine, fish oil, zinc, etc on a regular basis. I haven't tried hyperbaric stuff, although I am sure it would help and probably would do it if it was easily accessible/inexpensive, and I also haven't tried the deep brain stimulation, though I haven't looked into it enough to know whether I would do it even if I could right away. At the same time I feel I am better so I am not pushing too hard to try more things

First of all your info on TBI is outstanding so thank you, plenty to look into there.

ok, my assumption is with the hundreds of pages and the thousands of supplements mentioned in these pages there's a good chance most people are either on or have tried the supplements you mentioned, not just once but plenty of times!

I don't mean to offend but I'm going to put on my critical cap and ask, a bulletproof protocol means if you were to drop one of those supplements you wouldn't get the favourable results yeah, I mean outstanding if you've lucked apon the perfect combination, I've asked these questions years ago when people bang on about the latest supplement, no one ever seems to know which ones to keep and which ones to drop in their protocol. Pls share more info on yours, dosage? how you feel if you miss one etc etc??

I'd of thought other things critical to brain health would be selenium and B vitamins, melatonin for sleep....I could go on, I mean tell me which endocrinologist doesn't suggest taking selenium when they can't find anything else in the tests - that was rhetorical

So im either on what you've mentioned supplement wise or been on it meaning it could only be your meditation practice that's the difference in the success rate...,

1 hour ago, TrueJustice said:

First of all your info on TBI is outstanding so thank you, plenty to look into there.

ok, my assumption is with the hundreds of pages and the thousands of supplements mentioned in these pages there's a good chance most people are either on or have tried the supplements you mentioned, not just once but plenty of times!

I don't mean to offend but I'm going to put on my critical cap and ask, a bulletproof protocol means if you were to drop one of those supplements you wouldn't get the favourable results yeah, I mean outstanding if you've lucked apon the perfect combination, I've asked these questions years ago when people bang on about the latest supplement, no one ever seems to know which ones to keep and which ones to drop in their protocol. Pls share more info on yours, dosage? how you feel if you miss one etc etc??

I'd of thought other things critical to brain health would be selenium and B vitamins, melatonin for sleep....I could go on, I mean tell me which endocrinologist doesn't suggest taking selenium when they can't find anything else in the tests - that was rhetorical

So im either on what you've mentioned supplement wise or been on it meaning it could only be your meditation practice that's the difference in the success rate...,

 

I keep a diary of my mood, if I miss a few days in a row I feel worse, creatine being one of the main things that I notice the quickest, and multivitamins help a lot as well. That said, if I don't take zinc, fish oil etc for a while, I notice I feel better once I resume taking it. None of my dosages are especially high, because no point taking risks.

Creatine 5-3g per day
Zinc 1 tablet a day
Magnesium 2 tablets a day, one at morning, 1 at night
Multivitamin 1 tablet a day
Vitamin D 3-5000 IU/day
Fish oil 3 grams 2x per day.
Vitamin b12 1000mcg few times per week

These are things I am quite happy to take for the rest of my life, and at the same time if I miss a week its not the end of the world. Except for the b12, which I feel helps the scars of accutane and gives me more energy, the rest heals the brain and improves my mood, and also allows me to have a libido. My main three would be creatine, Zinc and fish oil, if I haven't had any for a while I really notice them when I start taking them again

I think that is you've just had accutane also consider taking vitamin K and taurine

Coffee still helps me shit...?

Could this be a boost in metabolism? Considering I have gained so much weight since all of this..

i used to be able to eat whatever and whenever

10 hours ago, Fchawk said:

When you suffer a TBI, the consequences are often delayed. With those NFL players usually they finish their career and are fine for a while, and often it is not not until well after retirement that those NFL players begin to suffer the more deleterious effects of brain damage, such as memory problems, depression, mood swings, endorconology problems etc.
The fact is that Accutane causes brain damage, and is scientifically proven to do so. It obviously doesn't do it by hitting you over the head, but it regulates chemicals in your body differently, changes your brain metabolism, and these effects last long after you stop taking it. My post has ALL the research and proof, and how to fix it. At the same time only one or two people have bothered to try it, even though it is 100% risk free, and would also cost less than $100 from your local chemist and doesn't require a prescription or anything. Here we have people saying take these tests, try to on these prescription drugs or steroids, etc, of which there are much larger risks and the people who have taken them are often only temporarily better and deteriorate after they stop taking them or have to keep taking them and they are still not satisfied with the results in the long term, as their body adapts to it or whatever.
In the last page I have someone who is trying out finistrade, which causes symptoms like ours but much more focused on the DHT/Hypothalamicpituitaryadrenal axis side of things, while DHT is only a part of the Accutane side effects. He is taking a much larger risk than my treatment, but if it helps him, it may be worth it. I tried a vitamin A treatment before I tried my current one, and it didn't work at all and I regret doing it, because it postponed my recovery a bit, but I guess in Edisonesque fashion I simply found another way to not cure Post Retinoid Sexual Dysfunction, and knowing that that was not the way helped me on my way to actually finding something that worked, and it also taught me to have a much stronger grounding in research before I made a diagnosis of what was causing my symptoms and what the way to get better would be. I guess at this stage I am frustrated that despite having spent over a thousand of hours doing research and now I have found a risk free, cheap accessible cure, which is the thing everyone seems to be searching for, it is just being ignored, and even though I have every step from diagnosis to recovery strongly grounded in research and studies people are still much more willing to take much greater risks that have no scientific backing or give up!!

Sure its not a pill you can just take and you will feel like your old self right away, it will take a few months before you get from 50% to 90%+, but most rehabilitation isn't as swift as the injury. You can hurt your back in a moment, and it can take months of physical therapy to rehab it, and so Accutane can do its damage quickly, and it will take several months of following the rehab to recover. Instead of looking for a magic pill that will fix it, and bemoaning the injustice that such a significant amount of damage was dealt to you for doing something that seemed trivial and most people do without consequence, just do the damn rehab and get rid of the back pain so you can get on with your life!

I really feel for you and also find it frustrating that we don't see people willing to try a cure when apparently they are so desperate.
We don't have people reporting their sides - this makes me so angry!!!!!
What we need now if a few guys to put their hand up and say "right, I am going to try this protocol and report how I get on"
If we could all pull together we might actually get somewhere.
I just hope that at some point common sense will prevail - stop the pharm drugs and be safe!
fchawk - hope you can stick around for a bit.
Please let us know if anyone has success with your protocol.

The thing with me and trying supplemental protocols right now is I'm still in the midst of getting lots of tests done. I want my body to be 100% untouched while I'm doing this. I haven't taken vitamins or anything in a really long time. The last thing I need is some stupid herb to skew a test that could be ridiculously important. Ya know?

Im down for supplements when all else fails but right now something is SERIOUSLY fucked up in my body as I'm spilling protein and have high blood pressure all the time. I'm not giving up

8 hours ago, Fchawk said:

9 hours ago, TrueJustice said:

Fchawk - I'm not sure there's anything in your protocol that we haven't already tried in terms of supplements? Everything listed there I'm either still on or have tried...

I totally understand your theory about TBI, the only thing I can think that might have given you some advantage is the meditation which you'd have to do daily, I use to do yoga daily that included meditation but no lasting results I'm sorry to say.

Have you done any of the hyperbaric stuff or deep brain stimulation??

No need for more science, totally believe the TBI theory with Roaccutane.

Didn't know any of you had tried it, as I haven't seen anyone mentioning taking creatine, fish oil, zinc, etc on a regular basis. I haven't tried hyperbaric stuff, although I am sure it would help and probably would do it if it was easily accessible/inexpensive, and I also haven't tried the deep brain stimulation, though I haven't looked into it enough to know whether I would do it even if I could right away. At the same time I feel I am better so I am not pushing too hard to try more things

I would like to see someone inc hyperbaric chamber, diet and IV glutathione - just expanding a little bit fchawk.
Not saying any protocol is easy!!

@guitarman01

@tanedout

I hope you guys find the following post on Phoenix Rising interesting : Connection of FOXO1 with Accutane and Finasteride. Several posts of people on Phoenix Rising with Liver iissues and abnormal Fibroscan tests.

http://forums.phoenixrising.me/index.php?threads/community-symposium-on-molecular-basis-of-mecfs-discussion-thread.53372/page-29#post-919238

A very interesting read (paper) for all you Post-Accutane sufferers is here. Please have a look :

https://www.ncbi.nlm.nih.gov/pubmed/22110774

9 hours ago, Fchawk said:

I keep a diary of my mood, if I miss a few days in a row I feel worse, creatine being one of the main things that I notice the quickest, and multivitamins help a lot as well. That said, if I don't take zinc, fish oil etc for a while, I notice I feel better once I resume taking it. None of my dosages are especially high, because no point taking risks.

Creatine 5-3g per day
Zinc 1 tablet a day
Magnesium 2 tablets a day, one at morning, 1 at night
Multivitamin 1 tablet a day
Vitamin D 3-5000 IU/day
Fish oil 3 grams 2x per day.
Vitamin b12 1000mcg few times per week

These are things I am quite happy to take for the rest of my life, and at the same time if I miss a week its not the end of the world. Except for the b12, which I feel helps the scars of accutane and gives me more energy, the rest heals the brain and improves my mood, and also allows me to have a libido. My main three would be creatine, Zinc and fish oil, if I haven't had any for a while I really notice them when I start taking them again

I think that is you've just had accutane also consider taking vitamin K and taurine

Thank you

I think that's a smart list there, couple of things that I'd add but you've probably got covered in your multi is both Vit E and C

Im rediscovering Vit D again and feel it lesson my aching bones and joints, it might be working together with C & E....I couldn't say for sure but I'm just glad it's helping.

1 hour ago, TrueJustice said:

Thank you

I think that's a smart list there, couple of things that I'd add but you've probably got covered in your multi is both Vit E and C

Im rediscovering Vit D again and feel it lesson my aching bones and joints, it might be working together with C & E....I couldn't say for sure but I'm just glad it's helping.

Yeah Vit D is one of the "legal" supps which made the biggest impact.
Zinc makes me groggy
Vitamine E makes me tired
Vitamin C gives me brainfog

Vitamin D gives me energy and makes my hair and nails grow. Yet i stutter alot more.
Semax give me energy now and then, its most of the time a hit or miss.
Piracetam is great, but dosing is very hard to get the right amount.
Rick Simpson oil was great, after that I regained my weight.

3 hours ago, mariovitali said:

@guitarman01

@tanedout

I hope you guys find the following post on Phoenix Rising interesting : Connection of FOXO1 with Accutane and Finasteride. Several posts of people on Phoenix Rising with Liver iissues and abnormal Fibroscan tests.

http://forums.phoenixrising.me/index.php?threads/community-symposium-on-molecular-basis-of-mecfs-discussion-thread.53372/page-29#post-919238

A very interesting read (paper) for all you Post-Accutane sufferers is here. Please have a look :

https://www.ncbi.nlm.nih.gov/pubmed/22110774

So if there was any liver fibrosis this wouldnt happen over night would it? is something having a negative impact on the liver that eventually could lead to fibrosis? Lets take propecia for example, how long does it take to induce sexual dysfunction and its other side effects?
Same with accutane. When you first notice these prolonged life altering sides does your liver have some form of fibrosis at this point?
I would probably think not. So maybe years down the line, you get a fibroscan and now you have mild fibrosis.
A person thinks see, it was the liver all along.
Im not sure if it proves that though.
If you're in a state of sickness or chronic inflammation, this could eventually catch up to you in many different ways.
For example Colinboko has protein in his urine post accutane, that has nothing to do with liver disease.
You see this more inline with cardiovascular disease or metabolic syndrome.
Hepatic involvement might just be a complication.

People have tried to treat liver health for years, including yourself with supplements like Tudca, Choline and everything else. So whats missing?

I'll call and inquire/look into how easy this test might be to get even with no signs of liver inflammation when I get a chance.
I relate it to trying to get a more advanced brain scan. They are not seeing anything to warrant it. Which is both good and bad.

9 hours ago, hatetane said:

I would like to see someone inc hyperbaric chamber, diet and IV glutathione - just expanding a little bit fchawk.
Not saying any protocol is easy!!

Haha, I find the majority of my protocol easy, thats why I am mad not more people are doing it! The hardest things to do are the keto diet and meditation, which are optional, all the rest take less than 5 minutes out of each day, and there is no reason to not do it!
As forhyperbaric oxygen therapy, it obviously helps a lot, its just I am just a poor uni student and I can get most of the benefits in inexpensive ways anyway, so I don't mind that I can't do it

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/

Hyperbaric chamber's are pretty easy to make and way better than the canvas (only go to 3PSI) knock offs that people are selling wayyy overpriced. The hard part is getting a prescription for Oxygen (U.S.), however if you have an old relative, maybe not so much. I have step by step details if you are interested, just PM me, but for starters: first get two 55 gallon steel drums, any industrial sales magazine or online, that's the first step, then come talk to me. I can help you make one. Estimated cost: $300-350 US. Estimated pressure 8-10 PSI.

I'm really starting to zone in on my damn immune system.

I literally used to get tonsil stones ALL the time... I barely get them now..

It has to be in over drive.

On 10/9/2017 at 7:23 PM, IndigoRushReturns said:

[Edited video out]

Obviously, don't excited by the title.
But here's a little update from my side of things.

Thanks for sharing this!!

On a serious note you speak very well about our condition - well done!!
on a lighter note, the psycho sexual part was funny as fuck the way you said it....I nearly drove off the road laughing

I know your 11 years in, sorry to hear that, I took it at 22 and killed off the best years of my life, I'm now 42 scared of having kids and facing a bleak future...

im hoping we get to the bottom of it all in the next 5-10 years if not sooner!!

thx again for making video