9 hours ago, tanedout said:

Well my bloods show high DHT, cortisol and low potassium. E hasn't been tested, but I have low e symptoms like stiff joints. He also says people with down-regulated receptors would respond quit well to topical progesterone - well I do, hence why I've been banging on about it recently, so this adds weight to the theories.

So you feel you respond well to progesterone, so you wouldnt want to take Mifepristone being that its a progesterone blocker?
But there is another group of people being differently affected where they would want to take Mifepristone because their progesterone receptors are being upregulated?
People have high cortisol, low cortisol, high testosterone, low testosterone, and the rest of their hormones might be all over the place or right where they need to be.
There dosent seem to be a consistent pattern,just that hormones might be being dysregulated.

Looking at HPA axis function, this isnt specific to accutane but it can be tested.
Endocrinologist. Thats one specialist i've never been to myself, but I have had alot of hormones tested over the years.

1 hour ago, Colinboko said:

Okay, so with inflammation still brewing in the back of my mind, I'm just exploring other routes

One of those being "high testosterone"

I know that sounds absolutely crazy but why are my arms SO much hairier than before accutane? Like I'm talking A LOT hairier. And it's also weird that I have high blood pressure..?

I'm hairy as hell also.
For me, my chest/stomach hair grows in patchy.

it's really bizarre, because some of the hairs come through the skin as stubble, but then stop growing entirely.
If I don't shave every week, it gets very itchy and looks strange.

The hair is also wiry, and I'm very self-conscious about it.

6 hours ago, IndigoRushReturns said:

Except we're now on page 548 of the investigation, and I'm guessing you guys are no closer to a solution - Am I right?

Im closer to realizing what accutane did or triggered might not be specific to accutane.
The door isnt shut. I think the more time that goes on the more will be discovered.
https://rxisk.org/launching-the-rxisk-prize/
I think awareness has been raised of Accutane. Its not nearly being prescribed as it used to. Thats why this forum seems practically dead at times. Which is a good thing.
Up and coming younger dermatologists I think are more aware of the dangers of Accutane or have more knowledge of, Even if they dont fully understand its mechanisms yet.
Patients are much more informed as well with the age of the internet.

3 minutes ago, guitarman01 said:

So you feel you respond well to progesterone, so you wouldnt want to take Mifepristone being that its a progesterone blocker?
But there is another group of people being differently affected where they would want to take Mifepristone because their progesterone receptors are being upregulated?
People have high cortisol, low cortisol, high testosterone, low testosterone, and the rest of their hormones might be all over the place or right where they need to be.
There dosent seem to be a consistent pattern,just that hormones might be being dysregulated.

Looking at HPA axis function, this isnt specific to accutane but it can be tested.
Endocrinologist. Thats one specialist i've never been to myself, but I have had alot of hormones tested over the years.

Mifepristone is an abortion pill, right?
How did we end up considering that as a way out of this?

I recently had my testosterone checked.
12.6 nmol/L, which is around 300 ng/dL - It's been like this years before.
It's considered 'normal' as it isn't under 8, but looks to be the range of an 80 - 100 year old.

I'm due to see the docs on Monday, but know I'm wasting my time.

3 minutes ago, guitarman01 said:

Im closer to realizing what accutane did or triggered might not be specific to accutane.
The door isnt shut. I think the more time that goes on the more will be discovered.
https://rxisk.org/launching-the-rxisk-prize/

$100,000? How far along is the funding?
How do you guys cope with earning money / holding down a job?

14 minutes ago, IndigoRushReturns said:

I'm hairy as hell also.
For me, my chest/stomach hair grows in patchy.

it's really bizarre, because some of the hairs come through the skin as stubble, but then stop growing entirely.
If I don't shave every week, it gets very itchy and looks strange.

The hair is also wiry, and I'm very self-conscious about it.

Now this is where it's different for me and kind of strange...

My chest, stomach and facial hair are not shedding and grow in pretty normally in comparison to my pre-tane self. 

My arm, leg, pubic, armpit and head hair all shed... 

But amongst that shedding, there are parts of my arms that are hairier now! Does not make much sense to me. Like the hair pulls out really easily and with a bulb on the end. Around my wrists and under my forearm are hairy!! Here's a picture. The red line represents where my arm hair USED to cut off at. Now it grows way past that...

I know we all probably feel shame for the sexual dysfunction and other related issues.
And that isn't a surprise.

But we need to remember that we have nothing to be ashamed of.
None of us chose this.
None of us were born with these defects.

The only ones who should be ashamed are the ones who did this - and continue to do this - to young men (and women) for money.
If Karma exists - and if we believe in any reasoning behind our existence, it has to - those who did this will meet their match.

2 minutes ago, Colinboko said:

Now this is where it's different for me and kind of strange...

My chest, stomach and facial hair are not shedding and grow in pretty normally in comparison to my pre-tane self. 

My arm, leg, pubic, armpit and head hair all shed... 

But amongst that shedding, there are parts of my arms that are hairier now! Does not make much sense to me. Like the hair pulls out really easily and with a bulb on the end. Around my wrists and under my forearm are hairy!! Here's a picture. The red line represents where my arm hair USED to cut off at. Now it grows way past that...

 

I could mistake that for my own arm, mate.
My Dad is actually super hairy too, but I still know I am hairier than I would be.
I shaved my ass earlier ... it was like a Gorilla beforehand.

On my face, my beard grows really high up.
No chance of growing a decent beard as it becomes very wiry after a week.
It looks really scruffy.

Still, no explanation for this side effect.
It's another mind-boggler.
 

19 minutes ago, IndigoRushReturns said:

I know we all probably feel shame for the sexual dysfunction and other related issues.
And that isn't a surprise.

But we need to remember that we have nothing to be ashamed of.
None of us chose this.
None of us were born with these defects.

The only ones who should be ashamed are the ones who did this - and continue to do this - to young men (and women) for money.
If Karma exists - and if we believe in any reasoning behind our existence, it has to - those who did this will meet their match.

I could mistake that for my own arm, mate.
My Dad is actually super hairy too, but I still know I am hairier than I would be.
I shaved my ass earlier ... it was like a Gorilla beforehand.

On my face, my beard grows really high up.
No chance of growing a decent beard as it becomes very wiry after a week.
It looks really scruffy.

Still, no explanation for this side effect.
It's another mind-boggler.

Have you had any urine testing done ever? I was recently diagnosed with proteinuria after having really bubbly/fizzy pee for a while.

There are a bunch of things that this could be but two that stick out could be

1. Testosterone dysregulation causing high blood pressure and then that is affecting my kidneys
2. Some form of chronic inflammatory response going on

2 minutes ago, Colinboko said:

Have you had any urine testing done ever? I was recently diagnosed with proteinuria after having really bubbly/fizzy pee for a while.

There are a bunch of things that this could be but two that stick out could be

1. Testosterone dysregulation causing high blood pressure and then that is affecting my kidneys
2. Some form of chronic inflammatory response going on

No, I've never had any urine tests.
My blood pressure is low, if anything - I get dizzy often.
I have a blood pressure machine at home - I've never been high.

Inflammation is more likely, but that's a bit of a broad term.

I have no clue
i barely have body hair and all that
my arms are blonde and thin

my nipple have hair and pubic and armpys
i get one maybe two on shoulder long pieces

facial hair grows up to my eye balls tbl and annoys me
but I can't grow a thick full beard
i don't really care about that tho

all i know is
i can't sleep since this drug i average 3 hours with meds
I'm waking up with my eyes crusted shut mucus like someone came inside them
or I wore contacts and stare into a fan all noght
i guarantee my eyes are the worst of everything
dark bags from lack of sleep
weigjt loss
rashes and facial flushing
cold hands feet
dry nose mouth scalp
weak erections sometimes

those re mainly my issues

if u it's have my issues I'm starting to believe
accutane twice did me in dry wise
lack of sleep not sure maybe stress anxiety yet meds don't fix that

the erection for me
is due to few things
for one I'm insecure how skinny I am
another I flush during sex and I hate that
anotner reason is my ex was druggie prostitute so that did a number on me
two other reasons anti depressants are known for erectile issues I use to b on them
and jerkinf off a lot no help

as far as lab work
and tests

my liver enzymes 2009-2015 were sky high
they never followed thru biopsy
now normal
my tsh was 6 me thyroiditis was confirmed ultrasound
took meds lost 35 pounds and stopped med of it was cured lol
triglycerides use to end super high
Lip biopsy negative

My cortisol morning was low
total t 12 range 9-50 seems low
and t level is 900 flagged high
estrogen high
igg4
ana speckled
zinc low
magensium low
vitamin d ow
cholestrol high
scheiemrs eye showed no tears

those are only things flagged for me

back pain went way after years (think it was because I sat all day
because when I became housebound again it came back
but it's gone now)

constipation (diet fixed some days if I don't eat and drink water all day it comes back )
hair loss (I had shedding when washing hair after thyroidnmed it got better
somedays maybe little but no concern
the eyenrows lashes fall out easy tho

memory she's still here and mental bs

i think we have to accept the drug did this
and maybe we can get some answers
maybe not

it sucks
but not like we can go back in time
and no one who didn't take the drug believes or even can relate

Anyone try the no fap thing
longrst I made it was a month
and it felt weird and didn't look healthy

other than that no benefits

obviously the drug fucked up the hormones

i highly doubt we all suffer same illness
because some of us have diff symptoms

example I feel like my sleep issues
no one else has
and dry eyes are severe

the hair loss excess hair brain stuff seems to be diff as I don't suffer with that
somwtimes fluid ringing in right ear but that could be damage from headphones as a kid or allergies

my point is I think we all either need to get together in person and go to doctors as a group

because we can't rely on others to get tests for shit s may not even be suffering with

this board is all over the place
I understand because we're all sick and want help

we need to get a symptom list and see what's what

9 minutes ago, IndigoRushReturns said:

No, I've never had any urine tests.
My blood pressure is low, if anything - I get dizzy often.
I have a blood pressure machine at home - I've never been high.

Inflammation is more likely, but that's a bit of a broad term.

And you haven't tried any medications?

Just supplements?

There were a few people that responded really well to prednisone. Could suggest an autoimmune aspect going on

Things like hirsutism and wound healing abnormalities you guys talk about are hallmarks of cushing's syndrome. But endocrinologist measures mostly systemic production, tissues synthesize cortisol from cortisone locally, so there's a real limit to what endo tests can say. But hair growth is affected by androgens and estrogen and those tests should be ok.

The gbolduev guy's ideas are worth looking into to see if they apply to your case, because he generalizes from real cases which has some value. The reasons for it working might be totally off though, it's super generalized, specially accutane.

His ideas about using mifepristone are more about progesterone than cortisol (is only cortisol antagonist in high dose), so less about macleod's study.

On 9/25/2017 at 4:26 AM, TrueJustice said:

Thx for info!!

what are you taking for tane issues??

list top 3 products pls?

I end up on different things every year. steroids and nootropics work best.

13 hours ago, macleod said:

So, got my lab results back from Rheum and everything checks out normal. Sed Rate, HLA-B27 antigen, C-reactive protein, ANCA screen, ANA screen.
This pretty much deflates any auto-immune angle I try to propose to doctors now, and to myself too, really. These results combined with my full CBC panel, hepatic panel, opthamology tests, mri's, ct-scan, endoscopy puts me in really good normal health.

Hate to say it but my primary care doc was right. Aside from finding low T, low FSH, and a pituitary microadenoma (so micro it may not even be there),I've kind of jumped the gun a bit. This leaves me with only pursuing neurologists to address hypermetabolism (tinnitus,night blindness, persistent afterimages, delayed wound healing, sleep disorder) of the brain and psychiatrists to address clinical depression and anxiety...

Sucks. But I tried...all year. I can't think of anything else. Maybe telomeres. Traumatic brain injury. Dunno.

What levels are your T and FSH (plus ranges) did you have E, SHGB, free T, DHT etc tested.
Also progesterone and DHEA needs to be tested.

6 hours ago, feastofvermin said:

Things like hirsutism and wound healing abnormalities you guys talk about are hallmarks of cushing's syndrome. But endocrinologist measures mostly systemic production, tissues synthesize cortisol from cortisone locally, so there's a real limit to what endo tests can say. But hair growth is affected by androgens and estrogen and those tests should be ok.

The gbolduev guy's ideas are worth looking into to see if they apply to your case, because he generalizes from real cases which has some value. The reasons for it working might be totally off though, it's super generalized, specially accutane.

His ideas about using mifepristone are more about progesterone than cortisol (is only cortisol antagonist in high dose), so less about macleod's study.

I end up on different things every year. steroids and nootropics work best.

Which ones? Please name a few!!

Colinboko - yes pubic hair does fall out easily, also yes I have wiry hair and as I said plenty of unwanted body hair similar to the above pics of arm.

Also I agree with those who question taking an "abortion drug" thinking this is the best way out of this mess - that to me is fucking crazy, having said that, looking more into Progesterone levels etc sounds like a good idea!

Regarding Mifepristone, obviously what it's used for doesn't apply to us in that regard. Accutane is used for acne, although it wasn't created for that purpose. It makes just about as much sense as the Clomid theories (a woman's fertility drug). We're trying to correct a negative feedback signal loop within our brains. Does anyone read the links or watch the videos i post?

Anyways, progesterone has a lot to do with the drugs listed above. Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. See the coincidence?

So, since a lot of your guys' complaints are androgen hormone related...Why not?

Sorry, what i'm trying to say is there is a pattern with these female hormone drugs and scientific studies + peoples PFS anecdotal trials claiming relief. Also, someone mentioned out CB1 and 2 receptors may be off, hence my suggestion for CBD oil.

check out this video, a lot sounds familiar?

Top 2 on my last resort to do list are Mifepristone and Cannibidiol Oil. Naturally i will try the oil first.

As for people with sleep issues and that "pressure" feeling in head, try Magnesium, I have been trying 250-500mg a day.

Magnesium,Sleep, and Mental Health.Magnesiumis well known for its ability to relieve insomnia. One study found that it helps decrease cortisol, the stress hormone that can keep you up at night. It also helps muscles relax, to give you that calm sleepy feeling and help you unwind after a long day.

Sorry for jumping around today, I too deal with this brain fog and have a hard time making my point.

Anyone else GAINING weight?

Curious to see if anyone else suffers from this because everyone always talks about being skinnier

12 hours ago, Colinboko said:

And you haven't tried any medications?

Just supplements?

There were a few people that responded really well to prednisone. Could suggest an autoimmune aspect going on

No, aside from an SSRI for 10 days - I was terrified of getting worse, and it was affecting me, so I haven't taken anything since.

For now, I'm looking into applying Ayurveda's principles.
Not sure if you've looked into it, but I have a 'Vata Dosha' dominance.
The symptoms are basically coldness and dryness in the body.

Ayurveda recommends a diet that counteracts that dryness.
It's suggested that I minimize (or eliminate entirely) foods like salad, crisps - anything that is dry or cooling.
Iced drinks would also be one to avoid.

Instead, I'm recommended to have warm/oily foods.
Foods like porridge, soups, stews are recommended.

Warm, herbal teas are recommended.

I won't get my hopes up, but I always have an intolerance to the cold weather and this is the time of year where I will shake like a leaf.
I used to be certain my thyroid was fucked, but the tests were always in range.

I'm taking lactulose, triphala and prunes for constipation, too.
I can never go to the toilet easily, as Accutane has probably reduced the oil/sebum within my entire body.
If I can't shit, of course a recovery will be impossible.

My constitution is Pitta/Vata.

You mentioned Triphala, other things to look into are Neem Leaves and Indian Gooseberry ( Alma ), this last one is actually good for constipation apparently.....

I've only used Neem to try and get rid of a fungal infection - this has since cleared!!

Did anyone here ever get rid of their eye floaters, if they had them?

They are so fucking annoying..

46 minutes ago, Iamme. said:

Did anyone here ever get rid of their eye floaters, if they had them?

They are so fucking annoying..

No... still another pain in the ass to deal with every day.

Seven months ago I made a post describing the cause of accutanes symptoms and how to cure them. I started it 4 months before I made that post, so it had been nearly a year. I stand by my cure and statements, I fully believe I am cured, though thats not to say its left it scars. I also feel I am ready to move on with my life, which I was far from being able to do 12 months ago, and I am optimistic about my future, as I feel I might well live past 90 with mind and body intact, whereas not so long ago I felt I would be lucky to make 70, even if I did everything right

What do we know about accutane? Well certainly the people that make it claim to know so little it is scary. All they claim to know is that it causes birth defects, and it somehow causes acne to go away. They also claim it causes no lasting side effects, except the magical disappearance of acne. However, that is because not everyone suffers the same side effects, though the loss of acne is the most common one. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy(brain cell death), which results in varying degrees of brain damage. Below or the studies that prove this, further down is how to fix it, which is very possible with the right knowledge
 
http://www.ncbi.nlm.nih.gov/pubmed/25689814
"A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)."
 
http://www.ncbi.nlm.nih.gov/pubmed/15863802
 
"RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. 
Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning."

 œA 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.
 
http://www.ncbi.nlm.nih.gov/pubmed/15251924
œWe now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/
"This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA."
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/#R173
"Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression."
"In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage."
 
https://www.ncbi.nlm.nih.gov/pubmed/20708044
"13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice."
 
Now that we have established that Accutane causes hippocampal atrophy and varying degrees of brain damahe, what are the consequences?
 
Traumatic brain injury: a disease process, not an event.
https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/
œTraumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.
 
Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge
 
https://www.ncbi.nlm.nih.gov/pubmed/16425236
œThe hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.

 
In this we see that accutane, in many ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane™s sides. That is because they DO help. 
Now we established that hippocampal atrophy may be the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally, though if you wish to use antidepressants as well that fine as well
 

Nutritional treatment for acute and chronic traumatic brain injury patients.
https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related
"omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a a TBI"
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/
Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least.
 
http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/
Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well.
http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/
 
Long-term effects of a ketogenic diet in obese patients
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
 
"Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania"
 
Currently I  doing:
Creatine - increases Dihydrotestosterone (DHT) and testosterone. Increases muscle power and ALSO improves neuroplasticity
Fish Oil - improves joint pain, helps heart disease, and ALSO improves neuroplasticity 
Zinc - increases levels of male hormones and ALSO improves neuroplasticity
Magnesium - helps with chronic pain, fatigue and insomnia and ALSO neuroplasticity
Vitamin D: Improves bone health, physical fitness, and ALSO improves neuroplasticity

    CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity
Multivitamin - makes me less likely to be malnourished. 
I try to do meditation regularly, but I don't prioritise it enough... Though it helps with anxiety and stress, as well as neuroplasticity, and i plan to add it into my daily routine.  
I feel much better than I have in years. I think for the last two months I have woken with morning wood 95% of the time, social anxiety is limited, confidence in my abilities in much higher, and motivation to reach my goals, and also willingness to do the work to reach them, is also one of the main things I have noticed. Before I did the work still expecting to fail, while now I do the work and I expect success, which makes me actually enjoy the work, and that™s just one example. My life and my future doesn™t seem so hopeless, there is plenty to celebrate and I™m sure plenty I will celebrate in the future
 
Things I plan to do:
Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and ALSO improves neuroplasticity
Ketogenic Diet: Improves body composition, can help ED, and ALSO improves neuroplasticity
I try to do meditation regularly, but I don't prioritise it enough... Though it helps with anxiety and stress, as well as neuroplasticity, and i plan to add it into my daily routine.  

Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help
 
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121947/
 
The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation.
https://www.ncbi.nlm.nih.gov/pubmed/18173322
œHigh-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.
 
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory.
https://www.ncbi.nlm.nih.gov/pubmed/21940440
œDeep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.
 
Nootropic agents stimulate neurogenesis. 
https://www.ncbi.nlm.nih.gov/pubmed/19441945
 
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/
 
Acupuncture stimulation induces neurogenesis in adult brain.
https://www.ncbi.nlm.nih.gov/pubmed/24215918

Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/

    "A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17].

Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.
https://www.ncbi.nlm.nih.gov/pubmed/14695924
COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time.  
 
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/
 
œIn animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients™ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs”both the trauma-exposed and unexposed members”had significantly smaller hippocampi than non-PTSD pairs.
 
here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/
The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or the worse his mental state before the injury happened the worse his recovery will be, rather than being optimistic improves outcomes

If you try this accutane rehab routine, post in https://www.acne.org/messageboard/topic/366988-curing-the-long-term-side-effects-of-accutane-both-mental-and-physical/#comment-3554261, because it would be nice to have a forum filled with what will be hope and recovery, instead of regret, pain and despair

Remember, it will leave scars, but after this cure you will no longer be trying to cure the whole brain fog, depression, anxiety, injury-susceptible, erection dysfunction, and the continuous and inevitable deterioration of health that the doctors can't seem to pinpoint the cause of, and instead it will be merely the scars, such as back pain, eye floaters, the occasional sore joint, low T, and unlike before, your body will be able to respond and heal so even those scars may fade a little. Good Luck everyone, I hope you all read this because I am no longer going to preach it. This is the cure that will put hope back into your lives, and personally I feel this phase of my life is over. I keep going back to this forum and I see some different names and the familiar names, and I notice former regular posters are missing. Maybe some of them have given up, mentally or totally, and thats why they are no longer posting, but I hope that the reason they are no longer posting is the same reason I'm not posting, and that is because while Accutane has nearly ended me in the past, due to my research and the positive effects of it I no longer feel accutane is a massive part of my life, nor that it is going to be a significant factor in my future, and so I can finally get on with my life. 

For libido , I found Levodopa works. I took200mg . It's prescription though. If you are unwilling to try this, you can try the natural 'Mucuna Pruriens', however this may not be effective.

I wouldn't suggest progesterone to any male, unless under thecare of a specialist and havea clear, identifiable deficiency. It raises SHBG, causes impotence, increases gyno, and suppresses the HPTA - all feminising qualities.

I am looking at trying low dose Clomid as well as my Test is low-normal.

@Fchawk
Im not sure if Traumatic Brain Injury would be the right term.
This would be similar to getting hit in the head with a baseball bat, or suffering a heavy blow to the head.
One minute your fine, the next your not. Its very sudden. Although people are sometimes not aware that it has happened.
Some of this could be measured with a MRI, in the case with NFL players and CTE not until post mortem.
Although it looks like there is a new advance scan that might. https://www.scientificamerican.com/article/study-finds-evidence-of-brain-injury-in-living-nfl-veterans/

Some of the advice and treatment could be similar. Could be. It could be the wrong thing as well. SSRI victims appear they are in a similar boat to post-accutane people . And look at what it might involve? Steroid genesis.
You cant argue with some of the studies specific to Isotretinoin, but then again its not that specific,

(and im not talking about taking Resveratrol, im talking about the disease process.)

Its good though to have some of these studies handy to print out to make ground when in front of any doctor and try to put it all together.
Thanks.

This could be the case with many drugs affecting hormone levels, and not just drugs but certain nutrients in excess amount. So whats happened to have this persist post treatment?
Its a check and balance process.

If high cortisol is so common in us, why hasn't anyone tried a solution from that angle?

Yeah, for sure it isn't 'Traumatic Brain Injury'', which isphysical external force to the skull.

6 hours ago, mikez said:

For libido , I found Levodopa works. I took200mg . It's prescription though. If you are unwilling to try this, you can try the natural 'Mucuna Pruriens', however this may not be effective.

L-dopa doesn't work long term unfortunately, you build a tolerance to it quite quickly and it becomes ineffective. Best to keep it for the odd day when you want a dopamine boost!

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I wouldn't suggest progesterone to any male, unless under thecare of a specialist and havea clear, identifiable deficiency. It raises SHBG, causes impotence, increases gyno, and suppresses the HPTA - all feminising qualities.

But you're on about a 'normal' person.. our bodies are out of balance post accutane, so many studies are likely not be relevant to us, one thing that makes this situation so hard to find answers for.

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I am looking at trying low dose Clomid as well as my Test is low-normal.

If you do I would suggest taking zinc supplements as you come off the clomid (just based on what the PFS guys are saying)