Anyone done the "Gut Thrive in 5" program in the USA?

There must be about 20 different supplements involved which is either way too much or a good quantity to completely restore gut health.

I've taken my fair share of gut supplements but have yet to try this program. I ask those from US as it's hard to import many of the supplements here to Australia unfortunately.

Ive spent the last 4 years or so avoiding dairy, avoiding fatty unhealthy foods, eating loads of fruit etc... Skins been unbearable.

I heard that diets low in fat can cause skin issues. Ive spent the last 5 days drinking pints of whole milk, eating tubs of double cream, having cheese on every meal and this weekend my skin is the best its been for a couple of years.

sounds like bull sh*t but its true and i just hope im not speaking too soon.

Thought id share, perhaps we all eat too healthily?

3 hours ago, Justdry said:

I heard that diets low in fat can cause skin issues. Ive spent the last 5 days drinking pints of whole milk

yea, i've noticed better skin myself it seems from time to time drinking milk. Which guess what it has? quite a bit of vitamin A, (which is probably a non-issue either way). It could also maybe have a minor hormone effect with the growth hormones in milk, like igf-1. It could also be that its a pretty good balance of protein,fat, carbs and vitamins/calcium

I know multiple people have mentioned gum sensitivity, gingivitis, and even periodontitis. This study could possibly show a explaining factor for a negative bacterial balance in the body. I know people have had issues with zinc supplements, myself included, but when I look at my blood copper serum levels compared to zinc,

My copper level has consistently been higher then zinc. latest test: copper 95 zinc 74. This is backwards from what the ratio should be. I'm also more concerned about soft tissue levels compared to what is showing in the blood.

Zinc in etiology of periodontal disease.

On 3/10/2017 at 5:03 AM, Walden Rev said:

He then posted some results a couple of weeks later.
Look at his Vitamin D levels.

Another thing I can say I take everyday is about 100mg of edible cannibas, not sure if this lead to any improvements but I have been taking it for a few years to help with depression and anxiety. I used to come here years ago but stayed away for 3 years because it made my anxiety worsen. I've been feeling my PFS effects everyday for 6 years and this 4 day span I had was more emotions and the most I've felt alive since the day I took saw palmetto and fin. Anyway I wonder if I hadn't stopped taking my vitamin regimen if I would still be recovered? Does it sound like I've had a "crash"?

after a few weeks following the recovery period I had, things are weird again. It seems as if I am more hyperthyroid now than hypothyroid, not sure if that is a good thing at all. Getting really nervous like I used to but it's visibly affecting me worse now. Here's my blood work I got back and would appreciate any input:


Testosterone: 295.20 NG/dl (175 - 781 NG/dL)

Free Testosterone: 49.6 pg/mL (6.0 - 224.0 pg/mL)

T3 Free: 3.88 PG/mL (2.5 - 3.9 PG/mL)

TSH: 0.96 ulu/mL (0.34 - 5.60 uIu/mL)

Vitamin B12: >1500 (200 - 914 PG/mL)

Vitamin D 25 Hydroxy: 43 ng/mL (30 - 100 ng/mL)

D2: >4 ng/mL (no range)

D3: 43 ng/mL (no range)

Yes, your TSH is indicative of hyperthyroid. I notice they didn't take any T4 labs. Are you on thyroid meds, or supplementing on your own? I noticed your B12 is high, some people have problems and symptoms with to high levels of b12, just like if you are too low!

Long Post, but highly recommend you read it all

What do we know about accutane? Well certainly the people that make it claim to know nothing. All they claim to know is that it causes birth defects, and it causes acne to go away. They also claim it causes no lasting side effects, which is obviously incorrect. However, that is because not everyone suffers the same side effects. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy, which causes varying degrees of brain damage

http://www.ncbi.nlm.nih.gov/pubmed/25689814

"A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)."

http://www.ncbi.nlm.nih.gov/pubmed/15863802
 

"Results: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. 
Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning."

œA 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.

http://www.ncbi.nlm.nih.gov/pubmed/15251924

œWe now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/

"This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/#R173

"Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression."

"In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage."

https://www.ncbi.nlm.nih.gov/pubmed/20708044

"13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice."

Now that we have established that Accutane causes hippocampal atrophy and varying degrees of brain damahe, what are the consequences?

Traumatic brain injury: a disease process, not an event.

https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/

œTraumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.

Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge

https://www.ncbi.nlm.nih.gov/pubmed/16425236

œThe hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.

In this we see that accutane, in many ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane™s sides. That is because they DO help.

Now we established that hippocampal atrophy may be the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally, though if you wish to use antidepressants as well that fine as well

Nutritional treatment for acute and chronic traumatic brain injury patients.

https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related

"omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a a TBI"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/

Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least.

http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/

Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well.

http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/

Long-term effects of a ketogenic diet in obese patients

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

"Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania"

Currently I  doing:

Creatine - increases Dihydrotestosterone (DHT) and testosterone. Increases muscle power and ALSO improves neuroplasticity

Fish Oil - improves joint pain, helps heart disease, and ALSO improves neuroplasticity

Zinc - increases levels of male hormones and ALSO improves neuroplasticity

Magnesium - helps with chronic pain, fatigue and insomnia and ALSO neuroplasticity

Vitamin D: Improves bone health, physical fitness, and ALSO improves neuroplasticity
CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity

Multivitamin - makes me less likely to be malnourished.

I try to do meditation regularly, but I don't prioritise it enough... Though it helps with anxiety and stress, as well as neuroplasticity, and i plan to add it into my daily routine.  

I feel much better than I have in years. I think for the last two months I have woken with morning wood 95% of the time, social anxiety is limited, confidence in my abilities in much higher, and motivation to reach my goals, and also willingness to do the work to reach them, is also one of the main things I have noticed. Before I did the work still expecting to fail, while now I do the work and I expect success, which makes me actually enjoy the work, and that™s just one example. My life and my future doesn™t seem so hopeless, there is plenty to celebrate and I™m sure plenty I will celebrate in the future

Things I plan to do:

Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and ALSO improves neuroplasticity

Ketogenic Diet: Improves body composition, can help ED, and ALSO improves neuroplasticity

I try to do meditation regularly, but I don't prioritise it enough... Though it helps with anxiety and stress, as well as neuroplasticity, and i plan to add it into my daily routine.  

Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121947/

The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation.

https://www.ncbi.nlm.nih.gov/pubmed/18173322

œHigh-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.

Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory.

https://www.ncbi.nlm.nih.gov/pubmed/21940440

œDeep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.

Nootropic agents stimulate neurogenesis.

https://www.ncbi.nlm.nih.gov/pubmed/19441945

Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/

Acupuncture stimulation induces neurogenesis in adult brain.

https://www.ncbi.nlm.nih.gov/pubmed/24215918

Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/
"A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17].

Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.

https://www.ncbi.nlm.nih.gov/pubmed/14695924

COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time.

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/

œIn animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients™ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs”both the trauma-exposed and unexposed members”had significantly smaller hippocampi than non-PTSD pairs.

here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/

The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or the worse his mental state before the injury happened the worse his recovery will be, rather than being optimistic improves outcomes

This is pretty much all the information needed for taking this approach to curing Post-Accutane Syndrome in one place. Obviously I would have missed things, and thats why I want everyone to discuss and suggest things that I have missed, and while I am certain that this will wipe away many of the sides, there are other mechanisms in which accutane acted, and while this counters one way it wrecked havoc in our lives, any ideas of the things we may do to address its other issues will always be appreciated

Love you all, don™t give up, we will continue getting better together!

Great post Fchawk

How do we stay on track with this guys? Or do you believe TBI isn't an issue - that we're better off addressing Thyroid and Testosteroneissues instead?

TBI sounds like it could be the major problem with majority of our issues being symptomatic of it.

Thoughts???

The thing is TBIs could be causing the thyroid and Testosterone problems. It could be something else that accutane did, but there is a very good chance it is due to the neurological changes it made to us

https://www.ncbi.nlm.nih.gov/pubmed/20504161
"TBIs increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury."
So yeah, symptoms of a TBIs can encompass pretty much anything, but while I cant promise it will fix everything, but it should still fix a lot and improve Quality of Life, with no potential of downside. Also many of the things which people have improved by having can be traced to them promoting neurogenesis, even if they didnt know it at the time

7 hours ago, Fchawk said:

The thing is TBIs could be causing the thyroid and Testosterone problems. It could be something else that accutane did, but there is a very good chance it is due to the neurological changes it made to us

https://www.ncbi.nlm.nih.gov/pubmed/20504161
"TBIs increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury."
So yeah, symptoms of a TBIs can encompass pretty much anything, but while I cant promise it will fix everything, but it should still fix a lot and improve Quality of Life, with no potential of downside. Also many of the things which people have improved by having can be traced to them promoting neurogenesis, even if they didnt know it at the time

accutane shuts off the sebaceous glands by TBI? if it doesnt, youre just treating symptoms imo.

4 hours ago, tryingtohelp2014 said:

11 hours ago, Fchawk said:

The thing is TBIs could be causing the thyroid and Testosterone problems. It could be something else that accutane did, but there is a very good chance it is due to the neurological changes it made to us

https://www.ncbi.nlm.nih.gov/pubmed/20504161
"TBIs increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury."
So yeah, symptoms of a TBIs can encompass pretty much anything, but while I cant promise it will fix everything, but it should still fix a lot and improve Quality of Life, with no potential of downside. Also many of the things which people have improved by having can be traced to them promoting neurogenesis, even if they didnt know it at the time

accutane shuts off the sebaceous glands by TBI? if it doesnt, youre just treating symptoms imo.

Thats an interesting point and one I've considered myself.

we all know tane can fuck up multiple parts of the body though so can it not do both? - cause brain injury and dry up the sebaceous glands?

Ah the joy of it all.....

3 hours ago, TrueJustice said:

Thats an interesting point and one I've considered myself.

we all know tane can fuck up multiple parts of the body though so can it not do both? - cause brain injury and dry up the sebaceous glands?

Ah the joy of it all.....

Bravo Fchawk. As always we got to keep looking at all aspects of health. I think NAC is a very important part of the protocol as it is a precursor to glutathione
I think Mark Gordon will replace T and use pregnanolone(check) if neccessary but starting with the mentioned supplements is a great start.
Many have said glutatione /taurine have really helped so this PBI is very interesting.
I just hope that anyone who tries this approach dose it properly and reports sensibly. No one is going to notice a difference in 2 or more hours or even a week. It will take at least 3 months to notice benefits and I think it would be good to take liver enzymes as well and as always good diet and exercise. Include meditation,deep breathing and hyperbaric oxygen chamber might help as well. Need to keep working on thyroid health.

Vit E, curcuminoids DHA.
Pregneolone (I got to stop confusing pregs)

How to implement this is key and that is why we all need professional guidance - if that is even possible. Certainly not possible in the UK

http://www.propeciahelp.com/forum/viewtopic.php?f=5&p=102379

http://www.medicationsense.com/articles/jan_dec_08/toxicity070508.php
http://blog.newsinnutrition.com/2016/01/pregnanolone-memory-cure/

My question is: Why the hell have no studies been done observing neurosteroid levels for ex-Accutane users? Are they low temporarily? Chronically lowered? I wonder if the PFS foundation would ever consider taking on our cause since we have so much in common. Some PFS researchers think neurosteroids are the main culprit in this mess, after-all! It seems to me that even if levels returned to normal at some point, long term deprivation of these neuroprotective/insulation compounds may have led to nerve damage or even brain damage.

A lot of you guys do some fantastic investigative work - thank you!!

My personal experience with fish oil isn't that much - I take "Udo's Blend" 3:6:9. I can't say I feel any better taking it but I continue to take as I know it's good for brain health amongst other things!
plus god only knows what tane has done to my arteries- I hope fish oil offers some protection.

For too long now I've been grinding my teeth when I sleep ( wonder why ) so I've decided I'm going to try "Tianeptine" I believe it's good for combating this as well as lifting mood, please share if you've had good results from this product?

If this doesn't work I may consider either St Johns Wort or Sam e.
Both for which I've been on in the past and they definitely help!

This is the funniest study I've ever read. Zinc is mainly a 5ar type 1 inhibitor not type 2. But zinc is also used in the medical field to help treat dehydration. It transports water and electrolytes from the intestine.

Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count.

Hey guys,

I'll take some time to report back on TRT this week. So far so good. I'm not sure it's the cure I was looking for, but mood wise, I feel like there are improvements. I'm probably getting my hormone levels checked this week, so within a couple days I'll know how its changed since.

Quick question regarding Zinc, as it's always been confusing to me that we'd supplement it when it's a 5-ARI. I finally bought some yesterday, and took 50mg zinc citrate before bed. I feel very odd mentally. Extremely thirsty. Face skin is burning with how dry it is. No libido, at all. Is this common for you guys when taking Zinc? It feels horrible. I'm used to drinking like 20 glasses of water a day... but I'm just.. so thirsty right now...

On 3/10/2017 at 5:03 AM, Walden Rev said:

He then posted some results a couple of weeks later.
Look at his Vitamin D levels.

Another thing I can say I take everyday is about 100mg of edible cannibas, not sure if this lead to any improvements but I have been taking it for a few years to help with depression and anxiety. I used to come here years ago but stayed away for 3 years because it made my anxiety worsen. I've been feeling my PFS effects everyday for 6 years and this 4 day span I had was more emotions and the most I've felt alive since the day I took saw palmetto and fin. Anyway I wonder if I hadn't stopped taking my vitamin regimen if I would still be recovered? Does it sound like I've had a "crash"?

after a few weeks following the recovery period I had, things are weird again. It seems as if I am more hyperthyroid now than hypothyroid, not sure if that is a good thing at all. Getting really nervous like I used to but it's visibly affecting me worse now. Here's my blood work I got back and would appreciate any input:


Testosterone: 295.20 NG/dl (175 - 781 NG/dL)

Free Testosterone: 49.6 pg/mL (6.0 - 224.0 pg/mL)

T3 Free: 3.88 PG/mL (2.5 - 3.9 PG/mL)

TSH: 0.96 ulu/mL (0.34 - 5.60 uIu/mL)

Vitamin B12: >1500 (200 - 914 PG/mL)

Vitamin D 25 Hydroxy: 43 ng/mL (30 - 100 ng/mL)

D2: >4 ng/mL (no range)

D3: 43 ng/mL (no range)

I also have high B12

I have found that anastrozole makes my symptoms way worse. I don't know anymore. About to try proviron

5 hours ago, Kynarr said:

Hey guys,

I'll take some time to report back on TRT this week. So far so good. I'm not sure it's the cure I was looking for, but mood wise, I feel like there are improvements. I'm probably getting my hormone levels checked this week, so within a couple days I'll know how its changed since.

Quick question regarding Zinc, as it's always been confusing to me that we'd supplement it when it's a 5-ARI. I finally bought some yesterday, and took 50mg zinc citrate before bed. I feel very odd mentally. Extremely thirsty. Face skin is burning with how dry it is. No libido, at all. Is this common for you guys when taking Zinc? It feels horrible. I'm used to drinking like 20 glasses of water a day... but I'm just.. so thirsty right now...

I experienced same effect of zink, 25 mg zink for me is like accutane, no sebum, dry skin and 0 libido, I avoid zink supplement. I think Zink is anti dht.

I' afraid to read top comments, after 6 cycle of accutane (20 months beetwen 2004 and 2012) what is the condition of my brain and frontal cortex?

51 minutes ago, cnb30 said:

Instead of focusing on all the little bullshit hormones and what not that screwed up, why don't we all realize we're fucked and go on a suicide attack against those who harmed us.

its sad, but is nice that some guys never lost hope. personally i lost hope, i lost my life. I come in this treadh some times for read a magic discovery. bu it is not yet happening

Can anyone in the US have a conversation with a PBI doctor? There are quite a few of them on youtube?

I am pretty sure the PFS researchers were approached about accutane before and refused to help. We should get our own response from then
so we know where we stand.
It is shocking that we don't have a team researching PAS.
I understand that they exclude PFS guys that haven't got sexual sides as that is there main area of research.

I tried to see if Dr Mark Gordon had an opinion on PFS but I couldn't find anything.
He really does a lot for free so if anyone can make contact with him it might give us some insight.

@ Accuity - I'm thinking your the man to reach out to an PBI expert LOL

1 hour ago, Ruvik said:

its sad, but is nice that some guys never lost hope. personally i lost hope, i lost my life. I come in this treadh some times for read a magic discovery. bu it is not yet happening

You know what would be really nice. Being back in Architecture school and not rotting away alone while everyone denies anything is wrong simply because corporate greed won't let the right information out. What we need to do is create as much pain and suffering as possible: harming and murdering the individuals responsible for damaging our sentience in the most painful ways possible as a means to
a- make sure justice is served
b- strike fear into the hearts of the murder corps

however, I am sadly currently unable to access a weapon.

I just want to add :The reason why we have no one researching PSA - the reason why kids are still being given accutane,
is because hardly anyone reports their
side effects.

Be honest - Who has reported their sides to the relevant authorities?

Anyone who hasn't reported - has played a part in the suffering that others following you, havesuffered!

No excuses, REPORT YOUR SIDES!!!

CNB30 - Suicide will not stop kids taking accutane - you will be accused of mass hysteria just like 'TheBridgend suicide incidents'
Every single time you see a doctor you should ask them if they are alerting (red flagging) side effects to the FDA or yellow card ETC.

I know if I was a doctor and a young guy comes insaying he has lost his libido and has ED and that he knows many other accutane guys are saying the same thing, I would besure to make sure every dermatologist in the area/country was made aware of the claims.

This is not happening and we are all responsible for this.

I asked my health authority under the 'freedom of information act' for any and all side effects that have been reported
to be made know to me and apparently no information like that is available.

This is madness - stop being complicit and do the right thing.

Except no doctor I talk to will report such things. And also wouldn't mass hysteria atleast bring such issues more towards attention

4 minutes ago, cnb30 said:

Except no doctor I talk to will report such things. And also wouldn't mass hysteria atleast bring such issues more towards attention

Nice to see your new meditation practice is working

40 minutes ago, cnb30 said:

You know what would be really nice. Being back in Architecture school and not rotting away alone while everyone denies anything is wrong simply because corporate greed won't let the right information out. What we need to do is create as much pain and suffering as possible: harming and murdering the individuals responsible for damaging our sentience in the most painful ways possible as a means to
a- make sure justice is served
b- strike fear into the hearts of the murder corps

however, I am sadly currently unable to access a weapon.

Just out of interest - would you speak out in the media about this?
Men are silent. We are all supporting merck with this silence.

Kudos Accuity and Indigo who have spoken out but unfortunately the message is not strong enough.

Am I on my own with this way of thinking or does anyone else agree?

4 minutes ago, hatetane said:

Just out of interest - would you speak out in the media about this?
Men are silent. We are all supporting merck with this silence.

Kudos Accuity and Indigo who have spoken out but unfortunately the message is not strong enough.

Am I on my own with this way of thinking or does anyone else agree?

I'd be down to speak about this though my psychologist and psychiatrist would probably try to discredit me and make me shut up

As far as I'm concerned me going in to see multiple doctors and specialists over the years - I've lost count how many and briefing them on my tane experience is my reporting. As to what they all do with the info provided is anyone's guess.

I only recently debated the madness of this drug with my doctor, she said unfortunately most patientswho come to see a doctor retain about 10% of info provided to them, her point being she could warn of the dangers of Accutane till she's blue in the face - many ( not all ) will still decide they want to go on tane it to fix up their acne. This ex applies not just to Roaccutane.

For me back in 1998, if you were to give me a comprehensive list of side effects I'd of looked at other options to fix persistent acne that was only on my back....absolutely no doubt about it!!