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Repairing the long-term damage from Accutane

 
MemberMember
9
(@mrjarjarbinks77)

Posted : 02/03/2017 12:08 am

Clear skin after Accutane. I haven't posted in awhile because I am so OCD with this stuff. After months of 80mg of Accutane, I am still dry. I feel older looking now but, I started posting in 2010. That is seven years. I stopped using Accutane in 2012.

Side effects were shedding hair, receeding hairline (ended up on hairloss talk for a bit). My lips still feel dry and so does my skin. I eat healthy. I am doing what I can to help heal.

I meditate and do martial arts. I sometimes do yoga. I am just being more accepting of myself.

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MemberMember
4
(@starrfeesh)

Posted : 02/03/2017 5:33 am

On 2/1/2017 at 11:22 PM, starrfeesh said:

Did anybody try/stick with the protocol from the youtube video '8 tips reversing accutane side effects?'

I know quite a few of us were taking calcium d glucarate for a while, some with good results, but curious if anybody tried all the recommendations?

The video mentions pale stools are a sign of cholestasis, which I do have. I think I'm going to give that protocol a try a long with LDN. Will let you all know how I get on.

Thinking of adding SAMe to this protocol as well. Has anybody had any luck with SAMe? This study shows it's effective in treating cholestasis.

https://www.ncbi.nlm.nih.gov/pubmed/2081476

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MemberMember
960
(@tryingtohelp2014)

Posted : 02/03/2017 9:09 am

9 hours ago, MonsterDiesel said:

If you took accutane avoid CLA (conjugated linoleic acid) supplements at all cost. I used some a few months ago and feel ill and toxic. I feel like I rebounded. Joints hurts more, libido is dead, depression is back and T levels are 300. It had been "stable" in the 500's for a while. Also, my cholesterol and triglycerides are high. Something they never were before.

This study explains why. CLA makes the liver dump retinols into circulation..

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759834/

I stopped the CLA a couple months ago but the effect lingers. I've been taking vitamin E and it seems to help a bit. Makes sense now.

Oh, and folic acid seems to be helping in terms of methylation and mood. Folinic and methylfolate make me feel lethargic and depressed.

My body also warmed up with folic acid and my chronic cold hands and feet disappeared! Iodine didnt help much if at all for this problem and I dont have any MTHFR mutations so felt safe to use folic versus the other two kinds.

I had this exact reaction. One pill of CLA , and my face started stinging because of the dryness!!!

the dumping of retinols makes sense...and further confirms a retinol problem.

copper is antagonistic in the liver with retinol
boron raises serum copper and ceruloplasmin
Vitamin D detroys retinol.
taurine binds retinol for excretion.

I still believe we have to mobilize it from the liver (but also REPLACE IT, so it just doesnt circulate back and get stored again) . the copper will mobilize and replace it in the liver.

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20
(@john86)

Posted : 02/03/2017 2:26 pm

Not sure if this is useful, but I got one of those telomere tests by Titanovo over a month ago, and finally received the results (with a length of 0.54). Judging by the graph, it's the median length for a seventy-year old?

telomere vs ss.png

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MemberMember
50
(@ehohel)

Posted : 02/03/2017 3:15 pm

18 hours ago, ACCUiTy_drANE said:
I don't even bother trying to bring up alternative treatments to conventional doctors. As another alluded to, IRC.BIO is one source. However, they recently got caught selling an impure product on their site (MK-677). Granted, MK-677 is a trickier compound to synthesize than Naltrexone. Another option is to buy from an overseas pharmacy such as Antiaging-Systems. Many CFS sufferers rely on that pharmacy for medications their doctor refuse to prescribe or their insurance won't cover. The same risks of buying supplements/meds online apply to this pharmacy as any other, but they're known for their reliability.

Lastly, I can attest to the legitimacy of LDN Doctor. You will have to pay $210 for the first online visit (in which you will likely acquire a prescription), and then you will have to pay $120 every six months for a renewal of the prescription. The medication itself is $50 for a three month supply of 4.5 mg pills. But you may not need to dose that high, so you won't need to refill as often. If you do require full-dose and use LDN Doctor, your grand total (appointments + medicine) will be $530 for a year supply for the first year and $440 for every subsequent year. If you buy DIRECTLY from an online pharmacy, you will likely spend $45-$50 for a month supply of 4.5 mg pills, so that's approximately $540 per year, plus shipping.

As I may have stated before, I love the concept of online doctors because you know exactly what you're getting into before spending money and time. That being said, does anyone know of reputable online thyroid doctors? Thank you.

IRC.bio made another statement on that same thread by the way.

also I've purchased my ldn from alldaychemist for those still looking.

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MemberMember
1803
(@guitarman01)

Posted : 02/03/2017 3:38 pm

15 hours ago, MonsterDiesel said:

 

If you took accutane avoid CLA (conjugated linoleic acid) supplements at all cost. I used some a few months ago and feel ill and toxic. I feel like I rebounded. Joints hurts more, libido is dead, depression is back and T levels are 300. It had been "stable" in the 500's for a while. Also, my cholesterol and triglycerides are high. Something they never were before

 

There could also be another explanation for this. Linoleic acid could have just caused burning in your stomach or stomach lining, that was already altered or inflamed post accutane. Linoleic acid is harsh and could have caused your stomach to produce more acid. It's also a ingredient in coconut oil
. Alot of people can't tolerate this. Let alone people thats stomach could have been altered post tane. Stomach inflammation can cause no symptoms even when it's severe. Maybe your body was responding in other ways to tell you something was wrong. Folic acid maybe helping because it's used to repair cells in the stomach and esophagus. Gastro Dr's use folic acid along with ppis and sulcurate(prob spelled that wrong) to try to reverse barrett's esophagus back to a normal state. I just don't think everything relates back to chronic retinol toxicity at this point. If this was the case I think our livers health would start to show it.

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MemberMember
42
(@kynarr)

Posted : 02/03/2017 4:48 pm

2 hours ago, john86 said:

Not sure if this is useful, but I got one of those telomere tests by Titanovo over a month ago, and finally received the results (with a length of 0.54). Judging by the graph, it's the median length for a seventy-year old?

telomere vs ss.png

And your age....?

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MemberMember
1804
(@truejustice)

Posted : 02/03/2017 4:49 pm

16 hours ago, MonsterDiesel said:

If you took accutane avoid CLA (conjugated linoleic acid) supplements at all cost. I used some a few months ago and feel ill and toxic. I feel like I rebounded. Joints hurts more, libido is dead, depression is back and T levels are 300. It had been "stable" in the 500's for a while. Also, my cholesterol and triglycerides are high. Something they never were before.

This study explains why. CLA makes the liver dump retinols into circulation..

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759834/

I stopped the CLA a couple months ago but the effect lingers. I've been taking vitamin E and it seems to help a bit. Makes sense now.

Oh, and folic acid seems to be helping in terms of methylation and mood. Folinic and methylfolate make me feel lethargic and depressed.

My body also warmed up with folic acid and my chronic cold hands and feet disappeared! Iodine didnt help much if at all for this problem and I dont have any MTHFR mutations so felt safe to use folic versus the other two kinds.

Sounds like you're on to something, why not get on CLA but match it with taking Calcium d Glucarate- draw that fucken poisen out of the body once and for all!!

Thats the thing that shits me about our situation - no test can show that tane still sits in our livers years later?. Posts about CLA kind of makes it look like it does huh!!

thx for posting

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20
(@john86)

Posted : 02/03/2017 5:02 pm

8 minutes ago, Kynarr said:
And your age....?

I'm thirty. Though I technically was twenty-nine when I sent in the sample. Not sure what it means, but it would be interesting to if former Accutane users generally have relatively short telomeres.

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42
(@kynarr)

Posted : 02/03/2017 5:10 pm

Met with the Neurologist today. Over two years on a waiting list only to be prescribed Naproxen. What a fucking joke.

I'll have to meet with an Endocrinologist if I want to get a scan to verify my Pituitary. This neurologist had no use for further testing as my ophthalmic migraines are presumably genetic, therefore the only *cure* is to take pills everyday for the rest of my life; no thank you.

Myaggressiveness has been ramping up in the past week, which I'd like to associate with increased T. I'll presume it's positive, but I will remain skeptic as long as I don't have blood results showing proper T levels, and most especially so long as I don't feel *normal* physically and mentally. I've had a couple short moments of absolute clarity since beginning TRT, but as far as I'm concerned, my T receptors might be so fried that my body doesn't even know what to make of the T I'm giving it. Time will tell. Again, strength has definitely improved, but my face is still dry. I'd think more T would solve this, but I guess not. My libido, oddly, has worsened. I just don't feel like having sex right now.

I'll look into testing my telomere length soon. Ehohel's and John86's testing gives me good indication that the telomere length of any Accutane user is significantly shortened.

This non Accutane user is getting retested sometimes this month, we'll see if Epitalon works mid-term soon enough:
[removed]

I'm not sure about CLA, but in case you guys are still onto the *vit A toxicity* theory, I'd tell you not to bother. Something somehow went wrong, but Accutane is long gone from our system. We might have more stored vit A than most people, but I highly doubt that's the problem.

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1804
(@truejustice)

Posted : 02/03/2017 7:52 pm

2 hours ago, Kynarr said:

Met with the Neurologist today. Over two years on a waiting list only to be prescribed Naproxen. What a fucking joke.

I'll have to meet with an Endocrinologist if I want to get a scan to verify my Pituitary. This neurologist had no use for further testing as my ophthalmic migraines are presumably genetic, therefore the only *cure* is to take pills everyday for the rest of my life; no thank you.

Myaggressiveness has been ramping up in the past week, which I'd like to associate with increased T. I'll presume it's positive, but I will remain skeptic as long as I don't have blood results showing proper T levels, and most especially so long as I don't feel *normal* physically and mentally. I've had a couple short moments of absolute clarity since beginning TRT, but as far as I'm concerned, my T receptors might be so fried that my body doesn't even know what to make of the T I'm giving it. Time will tell. Again, strength has definitely improved, but my face is still dry. I'd think more T would solve this, but I guess not. My libido, oddly, has worsened. I just don't feel like having sex right now.

I'll look into testing my telomere length soon. Ehohel's and John86's testing gives me good indication that the telomere length of any Accutane user is significantly shortened.

This non Accutane user is getting retested sometimes this month, we'll see if Epitalon works mid-term soon enough:
https://www.reddit.com/user/telomerotica

I'm not sure about CLA, but in case you guys are still onto the *vit A toxicity* theory, I'd tell you not to bother. Something somehow went wrong, but Accutane is long gone from our system. We might have more stored vit A than most people, but I highly doubt that's the problem.

Im saying this with respect. You say Accutane is long gone from our system, that 8 steps YouTube video suggest otherwise yeah!!

My question around that video and in particular the Calcium d Glucarate being needed to remove tane from the body, if we're to believe what that guy says doesn't it stand to reason that if we don't remove tane from body it will always be in us circulating through the system??

Ive suggested before that time alone won't heal us - 20 years on and I'm still affected, I can bury my head in the sand and pretend my life is fine but it's more in my nature to address problems and try to find solutions.

Some compensation from Roche would be welcomed!!

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42
(@kynarr)

Posted : 02/03/2017 8:13 pm

10 minutes ago, TrueJustice said:
Im saying this with respect. You say Accutane is long gone from our system, that 8 steps YouTube video suggest otherwise yeah!!

My question around that video and in particular the Calcium d Glucarate being needed to remove tane from the body, if we're to believe what that guy says doesn't it stand to reason that if we don't remove tane from body it will always be in us circulating through the system??

Ive suggested before that time alone won't heal us - 20 years on and I'm still affected, I can bury my head in the sand and pretend my life is fine but it's more in my nature to address problems and try to find solutions.

Some compensation from Roche would be welcomed!!

That video with 6k views? From an unknown youtube channel? That doesn't cite any source? Have you tried what this video proposes? I have. My very first idea was Vit A toxicity. I've since accepted it's not so simple.

I welcome any attempt to detoxify. Not just from Accutane, but from everything. EVERYONE should do more to help our bodies detoxify and remain healthy, but if you think all it takes is to supplement a couple naturals things and your bile flow will restart and flush excess vit A... man, you need to re-read this thread from page one.

I've taken over 150g of Calcium D Glucarate + Glucuronolactonoe over the past couple months. You know what it did? Nothing. I might have felt better on X Y Z instance while supplementing, but ultimately, here I am today, same as before. I've tried plenty of other supplements and vitamins suggested here. Again; nothing.

As far as anyone can tell right now, we're dealing with hormones issues. This has been very well established, yet nobody here seems to be getting their hormones checked and fixed. I find this highly questionable. Whether it's from a negative feedback loop, plain impaired ability to produce hormones due to glands having been wrecked by too much Retinoic Acid (and I fiercely maintain my GET YOUR PITUITARY CHECKED idea), or T receptors being fried, remains a guess. But please, after 20 years, you should know better than everyone here that your issue is NOT vit A toxicity. No longer at least.

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MemberMember
1804
(@truejustice)

Posted : 02/03/2017 8:47 pm

34 minutes ago, Kynarr said:
That video with 6k views? From an unknown youtube channel? That doesn't cite any source? Have you tried what this video proposes? I have. My very first idea was Vit A toxicity. I've since accepted it's not so simple.

I welcome any attempt to detoxify. Not just from Accutane, but from everything. EVERYONE should do more to help our bodies detoxify and remain healthy, but if you think all it takes is to supplement a couple naturals things and your bile flow will restart and flush excess vit A... man, you need to re-read this thread from page one.

I've taken over 150g of Calcium D Glucarate + Glucuronolactonoe over the past couple months. You know what it did? Nothing. I might have felt better on X Y Z instance while supplementing, but ultimately, here I am today, same as before. I've tried plenty of other supplements and vitamins suggested here. Again; nothing.

As far as anyone can tell right now, we're dealing with hormones issues. This has been very well established, yet nobody here seems to be getting their hormones checked and fixed. I find this highly questionable. Whether it's from a negative feedback loop, plain impaired ability to produce hormones due to glands having been wrecked by too much Retinoic Acid (and I fiercely maintain my GET YOUR PITUITARY CHECKED idea), or T receptors being fried, remains a guess. But please, after 20 years, you should know better than everyone here that your issue is NOT vit A toxicity. No longer at least.

I'll be honest, I don't know a fucken thing after 20 years and I can be forgiven for that with all the bullshit theories of this and that being the cure, our condition is confusing so I sympathise with what everyone has to deal with.

People have been banging on about CDG - but similar to you I got nothing from it, but before that the whole idea of doing 10-12 liver flushes seemed to of worked for just one guy who again posted his success on YouTube.

I actually agree with you - I dont have a Vit A toxicity issue after 20 years but it would seem based on posts that some do - If people are telling the truth about great results from CDG and that when they take CLA they feel really bad I'm assuming it's to do with Vit A toxicity correct? - why am I any diffetent to them even after 20 years?

Im really asking so i can stop this year buying any more unnecessary liver detox supplements and stop doing more Moritz Liver cleanses- eliminate any more bullshit theories. Until there's about 10 or more people who can advocate that something truly works, I'm considering it bullshit!!

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(@johnsmith21)

Posted : 02/03/2017 11:16 pm

Hey everyone. I know I hate on this thread bc I believe a lot of this is over blown and a bit obsessive. Not trolling at all, and this might have been discussed but who knows. Have any of you tried a ketogenic diet? I do it to get in shape before summer, but what I notice is extreme sharpness and a significantly better mood. Ketones are VERY good for cognitive performance. Also, a ketogenic diet is inherritabtly anti inflammatory (besides cheese which isn't good), as most of your food will consist of protein and vegetables. A Keto diet is essentially running on fat. What little people know is that your body actually uses fat far more efficiently then carbohydrate. Ketosis happens after about 4 or 5 days of under 30 grams of carbs per day. We know someone with Multiple sclerosis and this diet eliminated almost all of their symptoms. A lot of people criticize a keto diet, however, the studies are sound. It actually LOWERS triglycerides because your body RUNS on fat. You don't store ANY fat. I'm on a tangent lol. Anyway, you'll get into phenominal shape, and the ketones running through your blood will definitely improve mental symptoms to some degree. Keep in mind you'll feel like shit or the first week as your body adjusts, but after that hump you'll feel the best you've ever felt. Sharper, increased stamina, even high testosterone as the abundance of fat is good for test production. A LOT of athletes do this diet. It's great for becoming lean, great for stamina, and GREAT for hormones/insulin sensitivity and response.

Sugar (carbs) creates insulin spikes. This is not good for your body. Getting that end of the day crash is due to this insulin activity. A keto provides stable and constant energy through out the day as you are essentially never creating an insulin response. I actually read of a diabetic who didn't inject insulin for a WEEK on this diet. It does wonders. Look into a ketogenic diet and all of its bennefits, it seems as if many of you have tried almost everything so you have nothing to lose.

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MemberMember
0
(@abi72)

Posted : 02/04/2017 1:55 am

On 2/3/2017 at 1:50 AM, ACCUiTy_drANE said:
I don't even bother trying to bring up alternative treatments to conventional doctors. As another alluded to, IRC.BIO is one source. However, they recently got caught selling an impure product on their site (MK-677). Granted, MK-677 is a trickier compound to synthesize than Naltrexone. Another option is to buy from an overseas pharmacy such as Antiaging-Systems. Many CFS sufferers rely on that pharmacy for medications their doctor refuse to prescribe or their insurance won't cover. The same risks of buying supplements/meds online apply to this pharmacy as any other, but they're known for their reliability.

Lastly, I can attest to the legitimacy of LDN Doctor. You will have to pay $210 for the first online visit (in which you will likely acquire a prescription), and then you will have to pay $120 every six months for a renewal of the prescription. The medication itself is $50 for a three month supply of 4.5 mg pills. But you may not need to dose that high, so you won't need to refill as often. If you do require full-dose and use LDN Doctor, your grand total (appointments + medicine) will be $530 for a year supply for the first year and $440 for every subsequent year. If you buy DIRECTLY from an online pharmacy, you will likely spend $45-$50 for a month supply of 4.5 mg pills, so that's approximately $540 per year, plus shipping.

As I may have stated before, I love the concept of online doctors because you know exactly what you're getting into before spending money and time. That being said, does anyone know of reputable online thyroid doctors? Thank you.

http://www.curezone.org/forums/am.asp?i=2151914http://www.curezone.org/forums/am.asp?i=2151914

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MemberMember
0
(@abi72)

Posted : 02/04/2017 5:44 am

6 hours ago, JohnSmith21 said:

Hey everyone. I know I hate on this thread bc I believe a lot of this is over blown and a bit obsessive. Not trolling at all, and this might have been discussed but who knows. Have any of you tried a ketogenic diet? I do it to get in shape before summer, but what I notice is extreme sharpness and a significantly better mood. Ketones are VERY good for cognitive performance. Also, a ketogenic diet is inherritabtly anti inflammatory (besides cheese which isn't good), as most of your food will consist of protein and vegetables. A Keto diet is essentially running on fat. What little people know is that your body actually uses fat far more efficiently then carbohydrate. Ketosis happens after about 4 or 5 days of under 30 grams of carbs per day. We know someone with Multiple sclerosis and this diet eliminated almost all of their symptoms. A lot of people criticize a keto diet, however, the studies are sound. It actually LOWERS triglycerides because your body RUNS on fat. You don't store ANY fat. I'm on a tangent lol. Anyway, you'll get into phenominal shape, and the ketones running through your blood will definitely improve mental symptoms to some degree. Keep in mind you'll feel like shit or the first week as your body adjusts, but after that hump you'll feel the best you've ever felt. Sharper, increased stamina, even high testosterone as the abundance of fat is good for test production. A LOT of athletes do this diet. It's great for becoming lean, great for stamina, and GREAT for hormones/insulin sensitivity and response.

Sugar (carbs) creates insulin spikes. This is not good for your body. Getting that end of the day crash is due to this insulin activity. A keto provides stable and constant energy through out the day as you are essentially never creating an insulin response. I actually read of a diabetic who didn't inject insulin for a WEEK on this diet. It does wonders. Look into a ketogenic diet and all of its bennefits, it seems as if many of you have tried almost everything so you have nothing to lose.

Whatever else, exercise and diet are key!
https://www.pegym.com/forums/erectile-dysfunction-forum/79944-27-y-o-ed-pe-prostatitis-pelvic-floor-propecia.html
(see what Mr T says)
Also John, you may have seen me mention in in my previous posts - Shippen and other leading PFS doctors say cut carbs! (PM, I can forward the email I received from him but it is in my posts somewhere).

Kynarr - I agree that Thyroid damage and hormones are now the problem. No doubt caused by Vit A toxicity, although some guys report
problems after short term use.

I keep harping on about testing and nearly everyone says no problems with bloods. Well I don't believe it. Doctors may tell you that nothing is wrong but have you studied your own bloods?
PFS have found 2 consistent findings I believe - 3 adiol G and allopregnanolone.

So once again I ask if anyone had these tested? I think not!
We really do need a thread for blood test results - it really is the only way forward.

https://www.ncbi.nlm.nih.gov/pubmed/2972739
https://www.hairlosstalk.com/interact/threads/finasteride-taking-leads-to-allopregnanolone-depletion-in-human-brain.66214/

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MemberMember
1803
(@guitarman01)

Posted : 02/04/2017 9:56 am

You guys had your igf-1 , igfbp3 and gh levels tested? i havent. scratch igf-1, it looks like plenty of people have tested in range for that.

Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?

Abstract

BACKGROUND:

Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treatment.

OBJECTIVES:

To analyse whether isotretinoin has any effects on insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP3) and GH levels.

METHODS:

Forty-seven patients aged 21.5 +/- 5.1 years (mean +/- SD) with acne vulgaris were included in this study. Isotretinoin therapy was initiated at a dose of 0.5-0.75 mg kg(-1) daily and then adjusted to 0.88 mg kg(-1) daily as maintenance dosage after 1 month. Screening for biochemical and hormonal parameters was performed just before initiation and after 3 months of isotretinoin treatment.

RESULTS:

IGF-1 and IGFBP3 levels decreased significantly after treatment (P < 0.01), while GH levels did not change. Post-treatment, significant increases were seen in aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, triglycerides and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P < 0.0001) while high-density lipoprotein cholesterol levels were significantly decreased (P < 0.0001).

CONCLUSIONS:

Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association.

Approximately 95% of the IGF-I and IGF-II are bound to IGFBP-3, which makes this protein the major carrier of IGFs in plasma. One of the principal functions of binding proteins is to extend the half-life of the IGFs from eight minutes to several hours. In this way, IGFBP-3 acts as a stabilizer, providing a constant level of IGF. The serum level of IGFBP-3 appears to be a constant over 24 hours and the protein was found to be growth hormone (GH) dependent, which makes the detection of IGFBP-3 very useful in the evaluation of growth hormone secretion. Single IGFBP-3 measurements correlate significantly with the logarithm of the integrated spontaneous GH secretions.

Igfbp3 modulates cell proliferation in the hair follicle.

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MemberMember
1803
(@guitarman01)

Posted : 02/04/2017 10:53 am

also when i was talking about acid suppression, i didnt mean just enough to control the felt symptom of acid reflux. True justice said he was taking the equal of aciphex. which is prob 10 to 20mg. I meant to control what maybe going on in the stomach that wouldnt even be necessarily noticed. If there was a chance of around the clock increased acid production for whatever reason due to accutane, a minimum starting dose would be at least 60 mg aciphex,divided am and pm. or 40mg nexium twice a day(most potent) Things like kefir, probiotics, dairy, increase acid production. Stomach acid isnt the main means of food digestion. Its the enzymes the pancreas and small intestine create. it have to be am and pm acid suppression, because your acid would be rebounding in the middle of the night, And causing irritation that may make you for instance, have a headache the following day,sinus problems,ear fullness,fatigue because you didnt get a good nights sleep,, even as far as clinching your jaw and teeth at night because you cant breathe good, which could lead to jaw soreness and teeth problems and again a constant headache.
if this increased acid production started happening post tane due to basically a skin type change in the stomach.this process could maybe have been halted and reversed if caught in time. but nobody would have known. until all of a sudden you start getting facial flushing,foggy head, ear fullness, sinus issues, fatigue. but you dont associate it with this, and the problem just gets worse and worse. and maybe you could associate the stomach inflammation being in close proximity to your pecker that could effect the nerve sensitivity.
basal acid secretion is greatest at night between 12am and 3am i want to say. so if there was any issue going on this could trigger a immune response and you might not even be aware of it. But you could feel the effects the following day.you just wouldnt associate it with this "silent type of reflux" but its the most dangerous kind.
It would be nice to test too little/too much stomach acid. if this was a issue.

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MemberMember
15
(@johnsmith21)

Posted : 02/04/2017 12:29 pm

6 hours ago, hatetane said:
Whatever else, exercise and diet are key!
https://www.pegym.com/forums/erectile-dysfunction-forum/79944-27-y-o-ed-pe-prostatitis-pelvic-floor-propecia.html
(see what Mr T says)
Also John, you may have seen me mention in in my previous posts - Shippen and other leading PFS doctors say cut carbs! (PM, I can forward the email I received from him but it is in my posts somewhere).

Kynarr - I agree that Thyroid damage and hormones are now the problem. No doubt caused by Vit A toxicity, although some guys report
problems after short term use.

I keep harping on about testing and nearly everyone says no problems with bloods. Well I don't believe it. Doctors may tell you that nothing is wrong but have you studied your own bloods?
PFS have found 2 consistent findings I believe - 3 adiol G and allopregnanolone.

So once again I ask if anyone had these tested? I think not!
We really do need a thread for blood test results - it really is the only way forward.

https://www.ncbi.nlm.nih.gov/pubmed/2972739
https://www.hairlosstalk.com/interact/threads/finasteride-taking-leads-to-allopregnanolone-depletion-in-human-brain.66214/

A ketogenic or no carb diet has a crazy amount of bennefits

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50
(@ehohel)

Posted : 02/04/2017 1:16 pm

This is obviously a hormonal issue in the majority. Perhaps there is vit A toxicity, but I imagine the majority of the mental sides are hormonal. But then again I almost feel like it has to do with our immune systems given that out of everything I've tried I've felt the BEST, probably even "normal" on prednisone. (shutting down my immune system). And second best on an AI.

Anyone here get their IGF-1 levels tested before? I'm curious in experimenting with stronger GH drugsthan mk-677 or even real HGH (mostly for the anabolic gains though)

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MemberMember
1803
(@guitarman01)

Posted : 02/04/2017 2:14 pm

1 hour ago, ehohel said:

This is obviously a hormonal issue in the majority. Perhaps there is vit A toxicity, but I imagine the majority of the mental sides are hormonal. But then again I almost feel like it has to do with our immune systems given that out of everything I've tried I've felt the BEST, probably even "normal" on prednisone. (shutting down my immune system). And second best on an AI.

Anyone here get their IGF-1 levels tested before? I'm curious in experimenting with stronger GH drugsthan mk-677 or even real HGH (mostly for the anabolic gains though)

igf1 has been tested by numerous people on this board checking the history and has come back normal. not sure about IGFBP3 though.
prednisone is also used to treat eosinophilic esophagitis and eosinophilic gastroenteritis.
this is basically an allergic or immune response in the stomach and esophagus.
new studies are showing the damage caused by acid reflux isn't caused by the acid itself but an immune reaction to it.
I also read a study that they thought the light sensitivity caused by accutane was maybe due to a allergic type reaction.
eosinophillic esophagitis is also treated with a minimum of 40mg ppi and if that dosent work they treat you with a swollowed steroid like flonase. in more severe cases they treat persons with prednisone. prednisone i believe is the only treatment for eosinophilic gastroenteritis.
both are basically white blood cells being where they shouldnt be due to chronic inflammation.

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(@abi72)

Posted : 02/04/2017 3:33 pm

1 hour ago, guitarman01 said:
igf1 has been tested by numerous people on this board checking the history and has come back normal. not sure about IGFBP3 though.
prednisone is also used to treat eosinophilic esophagitis and eosinophilic stomatitis.
this is basically an allergic or immune response in the stomach and esophagus.
new studies are showing the damage caused by acid reflux isn't caused by the acid itself but an immune reaction to it.
I also read a study that they thought the light sensitivity caused by accutane was maybe due to a allergic type reaction.
eosinophillic esophagitis is also treated with a minimum of 40mg ppi and if that dosent work they treat you with a swollowed steroid like flonase. in more severe cases they treat persons with prednisone. prednisone i believe is the only treatment for eosinophilic stomatitis.
both are basically white blood cells being where they shouldnt be due to chronic inflammation.

Thanks for the history. If only these stats were easy to access. I just don't have time to research everything which is why I so often refer to the propecia forum - you can find everything there. But we have to remember that accutane is different even if it does cause similar damage - we have to believe this!! If only every member could fill out a survey - tick the boxes so to speak. We could start to keep records all in one place.
I unfortunately just don't have the skills to set this up!

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(@guitarman01)

Posted : 02/04/2017 4:22 pm

blood tests that may be used to evaluate pituitary gland function includeprolactin,free T4,TSH,cortisol,FSH,LH, andtestosterone.
then you can prob eliminatepituitary dysfunctionas well if people are coming in range on these test.

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(@abi72)

Posted : 02/04/2017 6:19 pm

50 minutes ago, guitarman01 said:
blood tests that may be used to evaluate pituitary gland function includeprolactin,free T4,TSH,cortisol,FSH,LH, andtestosterone.
then you can prob eliminatepituitary dysfunctionas well if people are coming in range on these test.

Serum testosterone - (TC) - normal 19.4 nmol/L 10.00 - 30.00nmol/L
Serum prolactin level 200 mlU/L 100.00 - 410.00m1U/L

Serum FSH level 4.1 lU/L 1.80 - 10.001U/L
serum LH 4.5 IU/L1.50 - 9.30 IU/L

serum free T4 level 21.1 pmol/L 10.30 - 24.50 pmol/L
serum TSH LEVEL 2.7 mlU/L 0.30 - 5.50 mlU/L

! Serum cortisol 809 nmol/L 130.00 - 580.00nmo1/L
VitD 76 under 80 insufficient

estrogen 18 pmol < 170 I believe this is way to low but endo says it's ok!

urine volume 2934 mL no range given but this is highlighted!
urine dopamine 2459 nmol/L < 2500 ??

!serum lipids - (TC) - c CHOLESTEROL level does not give raised risk of heart disease - starting a statin not indicated
Serum cholesterol 4.2 mmol/L 100 - 5.00 mmol/L
serum triglycerides 1 mmol/L 0.5 - 2.00 mmol/L
serum HDL colesterol level 1.5 mmol/L 1.00 - 1.9 mmol/L
serum LDL cholesterol level 2.2 mmol/L 1.00 - 3.00mmol/L
! total cholesrerol:HDL ratio 2.8 ratio
!Non HDL cholesterol level 2.7 mmol/L (Does anyone know why this might be highlighted when everything seems to be within range?)

Anyone with any knowledge please comment!

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(@truejustice)

Posted : 02/04/2017 8:06 pm

With reflux and taking the product Pariot ( if you're wondering, yes it works really well ) you have to monitor magnesium levelswhilst on it, recent blood tests checked out ok with 0.81, well within the reference of 0.65-1.00.

At the same time I asked for "hormonal balance check" in relation to growth hormone, I think this resulted from someone banging on about how good MK 677 is. I decided I'm not taking it unless there's evidence, well IGF-1 blood test came back at 25 well within the reference of 13-25.

All tests aside and I know others have said this but my body and in particular my face look 10-15 years younger than my age ( 41 )
I even get people commenting on this, my instincts tell me that tane did something to my growth and development ( took it at 22 )
even though blood work comes back normal!

Cholesterol - diff story, mine is too high and I'm currently trying to lower it with fish oil and eating oats etc!

What about the signalling in the brain and body though??? - that's got to be the key. Going to start this year pissing off the detox efforts and digging deeper into glands and how they function and how they effect hormones etc.

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