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I would think if there was still a chronic vitamin a toxicity, alot of these test results that everyone has gotten over the years would be coming back abnormal. For instance accutane causes elevated homocystine levels, lowered igf1 levels, lowered b12 levels, lowered vitamin E, lowered biotin activity, and the countless other studies showing what accutane alters. But they're not. They are coming back normal.
There are some key words here I underlined.
I myself have been diagnosed with eosinophilic esophagitis,was this due to accutane? will never know,but seems something similar happened here.
[Lung disease induced by isotretinoin].
Abstract
A young man without any past history of note had taken isotretinoin for disfiguring acne before the summer season. He presented with a severe bilateral pneumonia, associated with dyspnoea two months after the start of treatment. On the pulmonary radiography there was a bilateral ground glass appearance which was worse on the right. The elevated level of eosinophils (54% in 564,000 cells/ml) in the alveolar lavage lead to a diagnosis of allergic pneumonia. The rapidly favourable outcome following the cessation of the medication and with the addition of corticosteroids seemed to us a supplementary argument in favour of a diagnosis of eosinophilic pneumonia, due to isotretinoin which seemed the primary initiating factor.
Accutane and Eosinophilia - from FDA reports
Summary
Eosinophilia is found among people who take Accutane, especially for people who are male, 10-19 old , have been taking the drug for 1 - 6 months, also take medication Decadron, and have Acne . We study 29,825 people who have side effects while taking Accutane from FDA. Among them, 25 have Eosinophilia. Find out below who they are, when they have Eosinophilia and more.
Eosinophilshelp promote inflammation, which plays a beneficial role in isolating and controlling a disease site
On 2/3/2017 at 0:03 AM, MonsterDiesel said:Oh, and folic acid seems to be helping in terms of methylation and mood. Folinic and methylfolate make me feel lethargic and depressed.
My body also warmed up with folic acid and my chronic cold hands and feet disappeared! Iodine didnt help much if at all for this problem and I dont have any MTHFR mutations so felt safe to use folic versus the other two kinds.
I encourage everyone to take the time and fix any methylation issues you have. Since this is required by so many processes in the body, nothing else you do will work until your transmethylation pathways are functioning properly including detoxification.
Adding folic acid to my stack has been my second major breakthrough in 10 years since I discovered magnesium. My depression is gone, my body is warm, focus and concentration is much better and I'm enjoying things again.
My muscles always feel like a deflated balloon. Folate/b12 reverses this and my muscle hardness/tone returns. Its obvious to me that a dysfunctional methylation system is causing a lot of problems in my body. In addition, my joints feel better, smoother. No surprise since SAMe is marketed for joint health. Testosterone production also requires methylation/SAMe.
There's a lot of supplements that don't agree with me and make me feel sleepy, lethargic, like zinc, thiamin, vitamin c, etc. Yet I took some zinc yesterday and didn't experience this problem.
I also seem to be losing weight again. I've been stalled at 190-200 lbs for many years and folic acid is again helping. This study says that folic acid increases adipose tissue response to adrenergic stimulus and lipolysis in part by up-regulating receptors.
There's also polymorphisms in folate (MTFHR) and B12 (MTR/MTRR) that you need to work around but you will feel better once you do.
QuoteRetinoid-mediated hypomethylation of DNA has significant implications due to the link between DNA methylation and a number of important processes, such as gene expression and development
http://jn.nutrition.org/content/132/3/365.long
That means no healing or repair (gene expression) of any kind will happen until methylation is up and running again.
GNMT is chronically activated in our bodies. ATRA, Isotretinoin and regular vitamin A also activate it. That means all the vitamin A we get from food and whatever our livers are putting into the circulation are keeping this enzyme active.
Two things inhibit it that I've found: Methylfolate and Triiodothyronine (T3). I'm sure there are other things. Now, GNMT is a tumor suppressor, so permanent inhibition is not what you want either.
Excess dietary methionine upregulates GNMT. Glad I stopped taking methionine. Might explain my reaction to it over time.
GNMT is even present in the hippocampus. Any have memory and cognitive problems?
3 hours ago, MonsterDiesel said:http://jn.nutrition.org/content/132/3/365.longThat means no healing or repair (gene expression) of any kind will happen until methylation is up and running again.
GNMT is chronically activated in our bodies. ATRA, Isotretinoin and regular vitamin A also activate it. That means all the vitamin A we get from food and whatever our livers are putting into the circulation are keeping this enzyme active.
Two things inhibit it that I've found: Methylfolate and Triiodothyronine (T3). I'm sure there are other things. Now, GNMT is a tumor suppressor, so permanent inhibition is not what you want either.
Excess dietary methionine upregulates GNMT. Glad I stopped taking methionine. Might explain my reaction to it over time.
GNMT is even present in the hippocampus. Any have memory and cognitive problems?
Hi, do you monitor bloods or just go by how you feel?
A lot of what I think are original ideas have already been beat to death on this thread but never fully experimented on. They remained simple theories.
I'm entertaining a couple of theories. One is that that Retinoic acid is sitting on the receptor blocking normal vitamin A from locking on. That explains the anecdotal reports of people taking a single dose and succumbing to side effects plus all the permanent effects. Also, there's evidence that RA upregulates Retinoic acid receptors. R2 That might explain why we got toxic effects from a small amount of beta-carotene or retinol.
How else can we explain this?
I also believe it can be displaced but its gonna hurt..
The management protocol for isotretinoin induced night blindness involves taking vitamin A.
QuoteIsotretinoin was discontinued and the patient was started on vitamin A supplements (25,000 units) daily for 4 weeks. The patient responded completely to vitamin A supplementation (25,000 units) and his night vision recovered completely.
There was even a guy on this board that said his problems improved after using beta carotene. I messaged him to follow up. This study says that beta-carotene is converted to products that act as direct RAR antagonists. Article is free if anyone wants to read.
Also, have you noticed how the side effects from eating carrots are different than eating say, butter?
Quotehttps://www.ncbi.nlm.nih.gov/pubmed/22418437
Naturally occurring eccentric cleavage products of provitamin A -carotene function as antagonists of retinoic acid receptors.
Eroglu A1, Hruszkewycz DP, dela Sena C, Narayanasamy S, Riedl KM, Kopec RE, Schwartz SJ, Curley RW Jr, Harrison EH.Abstract
-Carotene is the major dietary source of provitamin A. Central cleavage of -carotene catalyzed by -carotene oxygenase 1 yields two molecules of retinaldehyde. Subsequent oxidation produces all-trans-retinoic acid (ATRA), which functions as a ligand for a family of nuclear transcription factors, the retinoic acid receptors (RARs). Eccentric cleavage of -carotene at non-central double bonds is catalyzed by other enzymes and can also occur non-enzymatically. The products of these reactions are -apocarotenals and -apocarotenones, whose biological functions in mammals are unknown. We used reporter gene assays to show that none of the -apocarotenoids significantly activated RARs. Importantly, however, -apo-14'-carotenal, -apo-14'-carotenoic acid, and -apo-13-carotenone antagonized ATRA-induced transactivation of RARs. Competitive radioligand binding assays demonstrated that these putative RAR antagonists compete directly with retinoic acid for high affinity binding to purified receptors. Molecular modeling studies confirmed that -apo-13-carotenone can interact directly with the ligand binding site of the retinoid receptors. -Apo-13-carotenone and the -apo-14'-carotenoids inhibited ATRA-induced expression of retinoid responsive genes in Hep G2 cells. Finally, we developed an LC/MS method and found 3-5 nm -apo-13-carotenone was present in human plasma. These findings suggest that -apocarotenoids function as naturally occurring retinoid antagonists. The antagonism of retinoid signaling by these metabolites may have implications for the activities of dietary -carotene as a provitamin A and as a modulator of risk for cardiovascular disease and cancer.
- PMID:22418437
Apologies if Im posting repeat studies or ideas..
Okay, guys. I took Accuutane 20mg for 5 months back in January - June 2011 and have suffered numerous bad long-term side effects ever since.
The first thing I want to say is that STAY THE FUCK AWAY from all vitamin a supplements I CANNOT RUSH THIS ENOUGH! Also ALL omega 3, 6, 9 supplements should be avoided too also Krill oil. Ingesting these supplements could make your sides 100x worse short and even long-term. Vitamin D, E and K should be avoided too, but they are not as dangerous as vitamin a and fish oil in my opnion, BUT SHOULD STILL BE AVOIDED! And that has to be for the rest of your life ALSO if you think you are 100% "cured" or just manging your symptons so you don't pay attention to them in your daily life. I can't explain excatly why you should avoid these supplements right now, but please just do it.
Okay with that out of the world I can tell you what side effects I had (or still have, because they will come back if I stop doing what I do)
Horrible social anxiety
Depression
Emotional numbness (no feelings, motivation etc, very scary!)
Brain fog
Loss of ability to think logical and analyze (had to drop out of school for 2 years and give up on my dream education forever)
Fatigue (not that severe. I know a lot of you guys suffer from this one really bad)
Eyes EXTREMELY sensitive to sun
Skin sensitive to sun, burn really easily even though I'mmediterranean and never burned before accutane
Seborrheic dermatitis in and between my eyebrows and nose creases
Horrible dandruff
IBS-Constipation (already had mild IBS before starting, but accutane made it 10x worse!)
Joint pain (mostly in my knees, but again not that severe)
Mouth uclers and sensitive gums that bled everything I brushed
^All these things was NOT problem BEFORE accutane! I know that 100%, For some reason I've never had an issues with dryness of skin, lips or eyes.. but our sides are all so different from another here on the forum.
But I am happy to say I've recovered from them all mainly because of Lugol's Iodine Jcrow brand (used other forms of iodine in the past, but I really prefer this one) I take 60mg daily (I use the 5% solution) I took 80mg daily for 2 years, but dropped back to 60mg because i wanted to save money and I found out I function just good on 60mg.
I would recommend starting on 6.25mg a day which is 1drop of the 5% solution and the ramp up the dosage as you want, but be sure to be on 50+mg after at least 60 days. You will first see the "full" results of what Iodine does to your body after 1 year on 50+mg (It took even longer for me and I was on 80mg daily), but you will notice the first benefits of Iodine within a couple of days. Just find the dose that works for you, but it takes time.
Also be sure to consume Doctors Best Magnesium GLYCINATE! (400-600mg daily), Natures Way Selenium (400mcg daily), Vitamin C as absorbic acid (3000mg daily), Folinic Acid NOT FOLIC ACID! (800-1200mcg daily), Methyl-B12 (>5mcg daily), ATP CoFactors (2x daily).
Also drink tsp UNREFINED CELTIC SEA SALT daily dissolved in water when on Iodine.
Other things that helped me have been; Source Essential Digestive Enzymes, Jarrow-Dophilus Probiotics, Marshmallow Root in pill form (amazing for ibs imo. Natures Way best brand), Slippery Elm powder (1 tablespoon dissolved in hot water to make as tea, drink 1x daily), L-Glutamine 100% powder (20mg morning, 20mg afternoon), couple of drops of 100% peppermint oil dissolved in water, Unfiltered Organic Apple cider vingear (everybody start drinking this daily) for IBS. Trial and error with a lot of this, but try the things. I really reccomend you all to start using digestive enzymes. Also when you take the Jarrow probiotics take them FIRST thing in the morning with a LOT of ice cold water (have lots of water in your fridge so it's always cold and ready) Take 5 pills a day and wait 45+ minutes to eat after taking them since digestive enzymes kills probiotics!
E45 shampoo, Apple cider vingear dissolved in spring water and a teaspoon of xylitol and left on affected areas for 10 minutes forseborrheic dermatitis. DO NOT USE ANY OILS ON SKIN OR IN HAIR IF YOU HAVE SEB DRM IT WILL MAKE IT WORSE LONG-TERM! I am 100% free fromseborrheic dermatitis to this day.
Brushing teeth with baking soda, 2 drops of oil of oregano, a bit of xylitol and 1 drop of iodine in the morning, brushing teeth with organic floruide free tea tree oil toothpaste in the evenings. Flossing 1x daily, mixing 1 teaspoon of pink himalayan sea salt crystals with hot water and rinse my mouth with the solution 2x daily. I also recommend oil pulling with coconut oil, but I dont have time for that right now in the mornings. Using Curaprox ultra soft toothbrush (switch to a new every 20 days) No uclers for years, bleeding gums 100% gone for years, teeth and gums so much better, teeth so much whiter and mouth much fresher. Mixing baking soda with water and rinsing your mouth with it is also recommended.
Eyes and skin was no longer sun sensitive after using Iodine daily for 8-9 months. Give it time.
Phenibut, L-Trytophan and Lithium Orotatehelped my mood and lifted my depression some what would reccomend it, but please get started on Iodine first. Don't play around with the 3 former too much.
Tried Cannabis in various forms for prolonged periods -honestly I was not impressed by the effects, but it could just be that the things I was able to aquire weren't that potent at all. Want to try it again.. sometime when i'm more financially secure and have a good chunk of money to throw around. Also want to Try LDN first.
Eat mostly plant based and organic with lots of vegetable/fruit juices, but treat yourself then and now if you know for sure that your body can handle it.
Also all of you guys in the US etc. get a quality water filter system installed please.
And everybody who feel like they have tried everything on earth including Iodine, 100% plant based diet, all nootropics and supplements GET ON LOW DOSENALTREXONE NOW. It seems like it's all the lost causes best shot by some miles. I will try and get on it too in the near future!
1 hour ago, Washer said:Eyes and skin was no longer sun sensitive after using Iodine daily for 8-9 months. Give it time.
Are you serious? How many years have you been sun sensitive before you started with Iodine? Sun sensitivity of eyes and skin is my worst permanent side effect for more than 15 years now.
Has anyone purchased the book "Accutane--is This Acne Drug Treatment Linked To Depression And Suicide?" by the United States Congress House of Representatives? It's available on Amazon. There is basically no information on the book itself, but based on books by the same seller, it seems to be a collection of public records kept by the U.S. government. I imagine the book will be a dry collection of studies and FDA memos (some relevant, some probably not), but perhaps there will be a few nuggets of valuable information in there. I'm really interested in the psychiatric side of things.
That being said, I've been dosing Sarcosine for a few weeks now, an amino acid found significantly more effective at treating depression than SSRIs. I'm definitely feeling an extra spark to my emotions/feelings. Sex drive is quite high again. If Accutane affected my sexual functioning at all, it would be in my drive (as I feel numbed out in all emotional aspects). But this is helping a bit, or maybe it's the fish oil + LDN + 5,000 IU vitamin D + whole food diet. Not sure I'm comfortable staying on Sarcosine long-term due to its tenuous association with cancer (it possibly activates other carcinogens) , but this stuff is regularly given to Schizophrenics who feel numbed out/blunted. And that is simply my exact problem. It's also in the same league as Ketamine for treating depression. At least look into it.
Lastly, if you're in a dark place and are willing to try anything to feel better, here is an article [Edited link out]by a highly educated psychiatrist on how to use pharmaceuticals in a SMART way to treat depression. It's a tough read, so if you want a TL;DR, feel free to message me to discuss. Depression can be treated with minimal side effects; it's just that most people/doctors/researchers don't understand how.
Honestly, I'm not playing with my hormones until I have the money to regularly buy TRT. Once you start tampering with hormones, it's possible things go awry. TRT can be $200 a month without insurance. I don't have that kind of money if something goes wrong. Down the line, I will explore that angle. But I have to prepared financially and emotionally.
There's this book I've also yet to find online for a reasonable price:
https://www.amazon.com/Retinoic-Acid-Structure-Mechanisms-Microbiology/dp/1621005976
TRT costs me 35$ here in Canada. I recommend the following book, as it covers a lot that this threads discusses, including SERMs, AIs, Vit D, Zinc.. you name it. Most everything we discuss here, TRT implicates. I would like to see other low T people try TRT, as it's the next logical step. SERMs and AIs have too many potential risks. It is better to try TRT first. This book helps understand why it's not so bad at all.
https://www.amazon.com/Definitive-Testosterone-Replacement-Therapy-MANual/dp/B01N2IDCNH
15 minutes ago, Kynarr said:There's this book I've also yet to find online for a reasonable price:
https://www.amazon.com/Retinoic-Acid-Structure-Mechanisms-Microbiology/dp/1621005976TRT costs me 35$ here in Canada. I recommend the following book, as it covers a lot that this threads discusses, including SERMs, AIs, Vit D, Zinc.. you name it. Most everything we discuss here, TRT implicates. I would like to see other low T people try TRT, as it's the next logical step. SERMs and AIs have too many potential risks. It is better to try TRT first. This book helps understand why it's not so bad at all.
https://www.amazon.com/Definitive-Testosterone-Replacement-Therapy-MANual/dp/B01N2IDCNH
You only pay $35 because you live in a rational country! 
I think TRT is fairly low risk, but it's when you attempt to make selective, "nuclear" modifications to your hormones that things can go wrong. So before I do that (if I ever do that), I need to be in a place that I can afford paying $200 a month for TRT to rectify anything I mess up. And even if I go straight to TRT (which is what I'm leaning toward), it has to be done under a doctor that understands the importance of balancing everything that can be thrown out of whack by testosterone. You're right that SERMs and AIs can cause a mess. Some people seem to be helped by them, but I'm not sure how sustainable it is, or if the risks are worth it.
Good source on the retinoic acid. We should all buy a copy and get our heads together. Or something.
4 hours ago, ACCUiTy_drANE said:Has anyone purchased the book "Accutane--is This Acne Drug Treatment Linked To Depression And Suicide?" by the United States Congress House of Representatives? It's available on Amazon. There is basically no information on the book itself, but based on books by the same seller, it seems to be a collection of public records kept by the U.S. government. I imagine the book will be a dry collection of studies and FDA memos (some relevant, some probably not), but perhaps there will be a few nuggets of valuable information in there. I'm really interested in the psychiatric side of things.
Thanks. The book appears to be a transcript of the first congressional hearing on the safety of Accutane. The full text is available for free here:
Accutane--is This Acne Drug Treatment Linked To Depression And Suicide?
https://www.gpo.gov/fdsys/pkg/CHRG-106hhrg73924/html/CHRG-106hhrg73924.htm
The omitted sections are included at this link:
https://babel.hathitrust.org/cgi/pt?id=pur1.32754070163500;view=1up;seq=1
9 hours ago, Roland1968 said:Are you serious? How many years have you been sun sensitive before you started with Iodine? Sun sensitivity of eyes and skin is my worst permanent side effect for more than 15 years now.
I came off Accutane in June 2011 - started experimenting with Iodine in April 2012 I believe, but I first started using Lugol's solution in December 2012 and that is the version of Iodione I had the most success with.
Many people make their own eyedrops with Iodine. I have never done that though since I first found out about it when my eyes where recovered. Read here; http://www.rawfoodsupport.com/read.php?9,210302
I started seeing a relief in symptons related to my skin and eyes after around 2 months on Iodine, but I was first fully "recovered" after 8-9-10 months I believe. I was using 80mg daily of Iodine - 40mg morning and 40mg evening dissolved in 4 ounces of water and with food.
11 minutes ago, Washer said:I came off Accutane in June 2011 - started experimenting with Iodine in April 2012 I believe, but I first started using Lugol's solution in December 2012 and that is the version of Iodione I had the most success with.Many people make their own eyedrops with Iodine. I have never done that though since I first found out about it when my eyes where recovered. Read here; http://www.rawfoodsupport.com/read.php?9,210302
I started seeing a relief in symptons related to my skin and eyes after around 2 months on Iodine, but I was first fully "recovered" after 8-9-10 months I believe. I was using 80mg daily of Iodine - 40mg morning and 40mg evening dissolved in 4 ounces of water and with food.
that is an unbelievably high amount. your post closely mimics this protocol for testosterone.
did you skin become oily again? wounds heal faster etc?
6 minutes ago, tryingtohelp2014 said:that is an unbelievably high amount. your post closely mimics this protocol for testosterone.did you skin become oily again? wounds heal faster etc?
80mg daily isn't a high dose by any means. Lot's of people who swear by Iodine take 200mgs+ daily and have done so for years. Just ramp up the dose SLOWLY. If you ramp up the dose too quickly there is a chance you could get a feeling of depression and depersonalization, but it's onlytemporary and isn't dangerous. There have been cancer patients (who have recovered from use of Iodine!) taking 500mg daily of Lugols..
And yes the protocol you have posted reminds a lot about mine, but we people post Accutane should avoid the Vitamin K supplement! Just make and eat fermented foods to get K.
I have never suffered from any libido related problem after Accutane nor have had lowtestosterone (and I have had many blood tests) so I can't say anything about Iodine's effects on that, but I strongly believe that it can help a lot of people who suffer from these pesky problems.
For everyone who wants to use Iodine to try and improve their sexual health and raise their testosterone levels (which if under 1000 TOTAL T is very low esp. if you are young like most of us here) should do their research on Iodine and how it (positively) affects your sexual health or just follow my protocol.
The thing about smearing Iodine on your testicles sounds legit. I might actually try it just to see what happens. I can't promise it will work for you guys though. Accutane damages your body in a lot of mysterious ways.. but it's worth a shot.
I still think Low Dose Naltrexone is the best shot for you guys with damages sexual health!
2 hours ago, Washer said:80mg daily isn't a high dose by any means. Lot's of people who swear by Iodine take 200mgs+ daily and have done so for years. Just ramp up the dose SLOWLY. If you ramp up the dose too quickly there is a chance you could get a feeling of depression and depersonalization, but it's onlytemporary and isn't dangerous. There have been cancer patients (who have recovered from use of Iodine!) taking 500mg daily of Lugols..
Do you ever experience anxiety from iodine?
3 hours ago, Washer said:I came off Accutane in June 2011 - started experimenting with Iodine in April 2012 I believe, but I first started using Lugol's solution in December 2012 and that is the version of Iodione I had the most success with.Many people make their own eyedrops with Iodine. I have never done that though since I first found out about it when my eyes where recovered. Read here; http://www.rawfoodsupport.com/read.php?9,210302
I started seeing a relief in symptons related to my skin and eyes after around 2 months on Iodine, but I was first fully "recovered" after 8-9-10 months I believe. I was using 80mg daily of Iodine - 40mg morning and 40mg evening dissolved in 4 ounces of water and with food.
What is your theory on how Iodine actually works in relation to Accutane problems??
Im always curious about processes, and in our case what the hell actually happened to us after taking Accutane.
As you know we've mostly been left in the dark on what it did to us. By taking an Iodine supplement what is it actually changing? Do you know?
1 hour ago, MonsterDiesel said:Do you ever experience anxiety from iodine?
From my experience it will only happen if you start out the treatment at a way too high dose (eg. 30mg+) or if you ramp up the dosage too fast (eg. going from 10mg daily to 80mg) and if it happens someone does that the effects will only last 2-3 days at max.
Iodine only greatly improved my social anxiety and other mental problems after Accutane.
1 hour ago, TrueJustice said:What is your theory on how Iodine actually works in relation to Accutane problems??Im always curious about processes, and in our case what the hell actually happened to us after taking Accutane.
As you know we've mostly been left in the dark on what it did to us. By taking an Iodine supplement what is it actually changing? Do you know?
I dont know what excatly happened to our bodies when we ingested Accutane and i will bet that nobody will ever find out, even if we get thousands of the worlds leading scientists to reverse engineer the drug down to the smallest micro-detail and research everything about all the compounds and how they affect the human body short and long term. The human body is the most complex thing on mother earth and will forever be. We will never even come close to understand how 5% of it works. That's how it is.
My five cents is that Accutane damages our glands in a million different complex ways. Again - we will never understand how and what damage specifically has been done, but we can still try and treat our symptons the best we can - we owe ourself that.
Iodine has a healing and soothing effect on our glands esp. our thyroid gland hence why it works for some of the sides.
LDN, Cannabis, Iodine, healthy eating, physical exercise, sunlight, meditation, avoiding all synthetic fat soluble vitamins in supplements is the things we should use to "psuedo recover" with. There is no magic pill we will take once and everything will be fine and there will never be such a pill for any health complication EVER. We need to be persistent with the things we try.
Everybody look into Low Dose Naltrexone. Also I don't have time to read all the pages + I hate how you can't search for specific words in a thread.. so I want to ask you guys what your experience with cannabis for managing side effects have been?
2 hours ago, guitarman01 said:Ingestion of greater than1,100mcg of iodine per day (Tolerable Upper Limits for iodine) (1) is not recommended and may cause thyroid dysfunction.
So 80x's this amount.
yes -this seems very high. @Washer: did you really take 80mg or was it 80mcg per day?
11 hours ago, TrueJustice said:What is your theory on how Iodine actually works in relation to Accutane problems??Im always curious about processes, and in our case what the hell actually happened to us after taking Accutane.
As you know we've mostly been left in the dark on what it did to us. By taking an Iodine supplement what is it actually changing? Do you know?
I think I know how. If you scroll up, I posted a study where T3 can turn off GNMT. I did a lot of research over the weekend and found a couple of more studies showing how T3 can circumvent a lot of issues caused by vit a toxicity since they are part of the same class of nuclear receptors..or something like that.
But it seems like the effect of T3 is a bandaid and you would have to stay on iodine/thyroid permanently.
Anyone ever had their neurotransmitters tested?! I've had loads of blood tests like a lot of people here, but clearly the issues go beyond getting a perfect hormone panel, and it would appear neurotransmitters are out of whack too, but you can get these tested and work with a doctor to correct imbalances, depending on what those are. Obviously imbalances can lead to issues everyone is familiar with:
Quote
It's All About Balance
A balanced nervous system is necessary to maintain optimal health. When the critical balance between the excitatory and inhibitory systems is lost, it creates a situation that increases the likelihood of a neurotransmitter-related condition developing. BALANCE = optimal health
Symptoms of Neurotransmitter Imbalance:
- Anxiousness
- Appetite control
- Attention issues
- Developmental delays
- Behavioral problems
- Low mood
- Fatigue
- Low libido
- Headaches
- Mood disorders
- Sleep disorders
Anyone had one of these tests? Anyone know if you can get them on the NHS without too much trouble?
Not surprisingly the link above advises that good diet and exercise are important, but you can take supplements to boost certain neurotransmitters (obviously), however despite many of the supplements mentioned in the above link being familiar to people who follow this thread (I've tried most them in the article on and off), has anyone actually taken them in response to actually been tested and confirmed as having low GABA for example, rather than just the 'stab in the dark' approach?.. You could test, attempt to correct whatever is low by suggested sups, retest etc.
The article also stresses that properly digested protein is critical to being able to create neurotransmitters properly, and witheveryone clearly having gut issues to some degree it's not hard to see how this could be a problem. On that note I've actually only fairly recently started taking digestive enzymes with meals and have found this improves digestions significantly for me, so I'd highly recommend them (I used ones which containBromelain and papain).
@MonsterDiesel- how much methylfolate are you able to take? I take an active B-complex (with some methylfolate included), and additional active B12 (Methylcobalamin), but I really can't tolerate much additional methylfolate - I get chest pains (seems to be a fairly common side effect). My 23andme does showI have 1/2 the MTHFR defect, but even so I'm surprised at how badly I tolerate it. Started this in response to this;
http://howirecovered.com/active-b12-therapy-faq/
Rich Van K over on Phoenix Rising (chronic fatigue/ME forum) reckoned a high dose of methylfolate would make sense as a potential resolution to tane sides by down regulating GNMT, but I've not been able to get anywhere near the likely required dose to try this (I've tried various brands as well);. From Rich Van K:
QuoteMy current hope is that using higher than usual dosages of 5L-methyl tetrahydrofolate (a component of the methylation treatment I have suggested), will eventually shift the epigenetics back to normal by suppressing the activity of glycine N-methyltransferase at the biochemical level, thus raising the available methylation capacity, and hopefully lowering the expression of this enzyme by methylating the DNA that controls its expression and breaking the vicious circle, so that things will come back to normal.
High dose Glycine was recommended as an upregulated GNMT would use up available glycine. ... but ive tried that with no results
we know for sure accutane alters the SAM/SAH ratio raising SAH
http://www.mdpi.com/1422-0067/15/5/8004/pdf
GNMT SAM/SAH ratio and copper.... this paper shows hi copper liver levels also raise SAH.... but if you read closely... a cu deficiency also raises SAH
Interestingly, Bethin et al. showed that Cu deficiency was also associated with 45% reduction of Ahcy hepatic levels [26], a finding that is similar to our results in fetal tx-j livers and that indicates that Cu metabolism must be strictly regulated to ensure stable Ahcy levels. Others showed that Ahcy deficiency in a 26-year-old man was associated with myopathy and developmental delay.