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http://www.foxnews.com/health/2016/12/20/now-schedule-1-drug-cbd-hemp-oil.html
6 minutes ago, Nicholas Ross said:
The body is very good at healing itself when it has what it needs.
I think using antioxidants long term is the way to go. Bonus if fat soluble.
Vit. D/k2/E, lycopene, reduced glutathione, SOD/catalase just to name a few.
Also I wanted to add a curious observation. I've been using slippery elm on/off for a year for dry mouth. Every time I do, I simply feel better. I've been in a rut since yesterday. This morning I dissolved 4 lozenges and within a short while, I was up, doing chores, cooking, listening to music and feeling pretty upbeat. I still am. I dont know the mechanism but the herb is rich in mucilage with coats your mucous membranes and adds moisture to the body.
On 12/23/2016 at 10:36 AM, MonsterDiesel said:The body is very good at healing itself when it has what it needs.
I think using antioxidants long term is the way to go. Bonus if fat soluble.
Vit. D/k2/E, lycopene, reduced glutathione, SOD/catalase just to name a few.
Also I wanted to add a curious observation. I've been using slippery elm on/off for a year for dry mouth. Every time I do, I simply feel better. I've been in a rut since yesterday. This morning I dissolved 4 lozenges and within a short while, I was up, doing chores, cooking, listening to music and feeling pretty upbeat. I still am. I dont know the mechanism but the herb is rich in mucilage with coats your mucous membranes and adds moisture to the body.
I had issues with dry mouth/throat, every since I started my new regimen I have unstoppable mucus production. Quite annoying actually.
4 hours ago, ehohel said:On 12/23/2016 at 10:36 AM, MonsterDiesel said:The body is very good at healing itself when it has what it needs.
I think using antioxidants long term is the way to go. Bonus if fat soluble.
Vit. D/k2/E, lycopene, reduced glutathione, SOD/catalase just to name a few.
Also I wanted to add a curious observation. I've been using slippery elm on/off for a year for dry mouth. Every time I do, I simply feel better. I've been in a rut since yesterday. This morning I dissolved 4 lozenges and within a short while, I was up, doing chores, cooking, listening to music and feeling pretty upbeat. I still am. I dont know the mechanism but the herb is rich in mucilage with coats your mucous membranes and adds moisture to the body.
I had issues with dry mouth/throat, every since I started my new regimen I have unstoppable mucus production. Quite annoying actually.
You got my attention. What does it involve?
On 12/26/2016 at 9:01 AM, ehohel said:Andrazole + MK-677Can't tell you which one exactly is causing the mucus production started them both roughly together.
Any joint pain from the Andrazole? I remember trying tamoxifen and it killed my joints.
Also, recently tried Creatine. Noticed a cognitive effects, energy and my workouts improved. Again though, it KILLED my joints and made me crash when I didn't use it.
I tried creatine, because I have low DHT and that's possibly the cause for my dryness which itself has caused many problems for me. I've had hairloss, but I have it pretty good under control with no-fap and minoxidil. With creatine I started to get hairloss again, freaked out and quit it. So I have low DHT, but if I try to treat it, I will get hairloss. There's no good option for me.
Now I've been taking arginine and first I got few little pimples and now I got joint pain. I did some kettlebells deadlifts and now my lower back has been aching since and my knees hurt if I do bodyweight squats. I used to do DLs and squats with heavier weights without problems.
On 25.09.2016 at 6:47 PM, tryingtohelp2014 said:What hormone panel did you get.. and what are the numbers?Estrogen dominance mimic the same EXACT symptoms. many people on here have had their testosterone numbers tested... soe come back high
its a specific test... im having a complete hormone panel... but you have to order a total estrogen count... not just the male estrodial number. (you have to get a womens test.) it would fit with the low libido, SIBO, Candida.
google candida and estrogen dominance (think eye floaters)
SIBO and estrogen dominancecalcium D glucarate .. our livers are so backed up, that we cant eliminate estrogens the correct way anymore? Gilberts disease would make it worse.
many people on these forums take DIM and calcium D glucarate for acne. its mostly women... but the results are astounding.
I3C indole 3 Carbinol or Zinc would do the same thing.... clear excess androgens and estrogens.
Estrogen and Cholestasis..... i know we keep going to in circles about glucuronides of accutane being stuck.. but what about Estrogen not being able to be detoxified due to the drug as well? causing a loop?
Read these two paragraphs below... is this why Calcium D Glucarate and UDCA are recommended in the solving the accutance problem video?
Estrogens
[edit]Estrogens, and particularly glucuronides such as estradiol-17²-D-glucuronide, have been shown to cause cholestasis in animal studies, by reducing bile acid uptake by hepatocytes.[7]
Treatment[edit]
Upon diagnosis, many providers will prescribe Ursodeoxycholic Acid. While there is no cure for ICP, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of Ursodeoxycholic Acid, whereas Cholestyramine appears to only relieve itching.[7]
If additional blood tests to check clotting function identify a problem, giving Vitamin K may help avoid the risk of hemorrhage at delivery.
Delivery by 35“37 completed weeks may be important to fetal outcome as a recent study demonstrated that in severe ICP (defined as bile acids greater than 40 umol/L) the risk of stillbirth was 1.5% compared to 0.5% of uncomplicated pregnancies. This risk rose further if bile acids doubled,[12]
Since estrogen is detoxified the same way as accutane... maybe accutane caused a block here...
http://onlinelibrary.wiley.com/doi/10.1002/hep.1840030422/abstract
So maybe get a total estrogen test ... even a progesterone test as well. i know these are for women...but maybe it will show something. (all 3, not just the one E1 E2 E3) ...
then a treatment of:
Calcium D glucarate
DIM
Indole 3 Carbinol
TUDCA
Ok these are my results. Estradiol is high and explains most of my problems.
Summary after 3 years: Low testo, high estrogen..
@MrErdemDid you also get DHT by any chance? You'd almost certainly see benefits from Anastrozole or one of these pro hormone formulas thats got loads of reservatrol in like AndroHard or Sustain Alpha, these bring down E2 a lot, but you don't want to crush it or you'll end up with achy joints etc and have to wait for it to rise up, so I'd go slow with whatever you try.
17 hours ago, MonsterDiesel said:Any joint pain from the Andrazole? I remember trying tamoxifen and it killed my joints.Also, recently tried Creatine. Noticed a cognitive effects, energy and my workouts improved. Again though, it KILLED my joints and made me crash when I didn't use it.
Joint pain is starting to arise now, I'm going to drop dosage to like 0.25 MG every other day.
Magnesium Citrate (400 mg per day) + Low-dose Naltrexone (4.5 mg per night) has put my IBS in 90-95% remission. This regimen has worked better than any dietary intervention I have ever tried. This includes years of being gluten-free, dairy-free, and taking probiotics. The Magnesium actually does a lot by itself to curtail the bloating, gas and incomplete elimination. But LDN seems to make things a little better. I still feel a bit off in the mornings, but my embarrassing symptoms are no longer hanging over my head whenever I'm around people. I have stopped stressing about diet recently, as these supplements work better than literally anything.
Low-dose Naltrexone (4.5 mg per night) + Agmatine (2 grams per day) has also put a large dent in my anhedonia. Mentally, I feel 50-60% better. For the past two weeks, I have been feeling some reignited excitement for my hobbies. I actually feel capable of enjoying things, rather than looking at every activity as a mere distraction. I know something is up when I am actually looking forward to seeing people and engaging in hobbies. Sleep is better as well. What's interesting is that all of these substances have tolerance-reducing properties. They appear to work by upregulating your naturally occurring receptors. Agmatine (metabolite of L-Arginine) is said to reset one's tolerance for opioid medications and stimulants, partially through NMDA antagonism. LDN upregulates and sensitizes endogenous endorphin receptors, in addition to increasing endorphin production.
I know I will still get in a rut and progress won't always be linear, but in the last two weeks, 12 of those days have been pleasurable. Usually, I only have one-two days per fortnight in which my anhedonia is low. It seems I am more resilient to stress. In the future, I plan on looking into trying similar compounds such as Memtantine, which is also a NMDA antagonist like Agmatine. We know Memantine has effects on the immune system (as does LDN), and I suspect Agmatine does as well. Not to mention, Magnesium regulates NMDA receptors. I encourage people to research this angle given my profound results.
Magnesium is pretty awesome. I've been taking 500mg daily for a month in conjunction with Iodine, vit C and vit K. I recommend you look into this post as Citrate is not the ideal version. Look into Glycinate.
[Edited link out]
Next on my list is to request a brain scan. I've been on a waiting list for it since Sept 2014 due to ophthalmic migraines, but I'm getting sick of waiting so I'll get it done somewhere else, ASAP. My goal is to verify the Pituitary Gland. Everything always points back to it.. including magnesium.. including LDN.. including Agmatine. I'm sure it's this gland that is the issue. Accutane must have wrecked it.
Can you guys clarify why Anastrozole causes joint pain? Ehohel, any sides you can attribute to MK-677. I've been getting ready to order some, but it doesn't seem completely devoid of sides, is it? How do you feel about this SARM at the moment? I don't have any new supplement or protocol to try besides MK-677, so that will be next. I feel like I'm already taking all the supplements I should. Diet is top notch. Gym performance is at its best yet. I still have many issues, but this right now is a definite improvement from June this year. Main cloud over my head is my T levels, and how hard it is to obtain a proper body composition. Working on it.
I'm reintroducing Creatine. I had never noticed it increased DHT. I've been reading so much I somehow blocked this fact from my mind. I recently supplemented some EGCG, as I had done in 2013, and somehow, I feel it made things worse. I read a bit on it and... it's a 5-ARI. Of course.
https://fr.scribd.com/document/270850865/5-alpha-reductase-inhibitor-pdf
Lastly, there's one thing I can't seem to understand. Why is Zinc recommended among us? I've yet to try supplementing Zinc, but isn't it a 5-ARI too? What's good about it?
On 12/22/2016 at 7:55 AM, Weltschmerz47 said:What's interesting is that a lot of stuff that seems to work for both accutane and propecia sufferers (Resveratrol [main ingredient in sustain alpha], zinc, and vitamin e) are some of the strongest downregulators of FOX01. Look at https://www.selfdecode.com/gene/foxo1/#all-ways-to-decrease-gene . So, if you wanna take that angle.. i think we can confirm that that is something some people can work on. I feel I am going to be back to normal within half a year with my current level of sustained progress. Try to avoid reading negative posts.. can't deny that you can psychologically make this condition worse than it is in reality. A healthy lifestyle can fix anything, time and effort is all you need
Excellent link, and I have heard people speak kindly of Resveratrol. However, this study concludes that "Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells." We knew it had anti-cancer qualities, but it appears to have apoptotic effects through a similar mechanism as Accutane. :\ I'm not saying Resveratrol's apoptotic effects are as broad as Accutane's, but this certainly doesn't look like a FoxO inhibitor. Let me know if I'm off-base.
On 12/30/2016 at 10:31 AM, Kynarr said:Magnesium is pretty awesome. I've been taking 500mg daily for a month in conjunction with Iodine, vit C and vit K. I recommend you look into this post as Citrate is not the ideal version. Look into Glycinate.
[Edited link out]
I'm aware that Glycinate is touted as superior, but Citrate is a perfect balance between cost and bioavailability. Also, the mild laxative effects are likely part of the reason it is so beneficial to me. Now, Oxide is pure trash in comparison. 
On 12/30/2016 at 10:31 AM, Kynarr said:Lastly, there's one thing I can't seem to understand. Why is Zinc recommended among us? I've yet to try supplementing Zinc, but isn't it a 5-ARI too? What's good about it?
The theory goes that some of us are low in DHT and some of us are high. If you're high, Zinc is theoretically better. If you're low, Creatine is theoretically better. I'm not sure I believe that either compound would be particularly beneficial, but I'm open-minded. Zinc is a pretty weak 5-ARI though. However, I generally avoid any other isolated compounds that are 5-ARI, including things like medicinal mushroom extracts. Whole foods are probably fine though.
Creatine reliably causes me to break out, which isn't necessarily a bad thing. If anything, that shows it probably does impact my DHT. I would have to experiment again (for a sustained period of time) to know if it helps my cognition/anhedonia.
For the past few weeks, I've started taking Lamotrigine for my anger issues, which I definitely think is due to Accutane. I think i'm feeling better. And also I take Valium and/or Xanax for anxiety due to the after effects of Accutane. It's hard to blame it all on this drug, because I've had a history of depression and bipolar.I definitely feel like something in my personality is missing though. But i've noticed i've been more social lately so that's a plus.
From what I've read on the forum, getting a sex hormone test or testosterone test would be interesting. Maybe i'll give it a go. Would be interested in hearing anyones experience with testosterone.
I've tried a supplements but they don't really do much for me...I would suggest a low does mood stabilizer for anyone feeling aggressive because of this drug.
I've tried living healthy and prescription drug free but got so sick of it. Can't handle the stress anymore.
On 12/30/2016 at 10:31 AM, Kynarr said:Magnesium is pretty awesome. I've been taking 500mg daily for a month in conjunction with Iodine, vit C and vit K. I recommend you look into this post as Citrate is not the ideal version. Look into Glycinate.
[Edited link out]Next on my list is to request a brain scan. I've been on a waiting list for it since Sept 2014 due to ophthalmic migraines, but I'm getting sick of waiting so I'll get it done somewhere else, ASAP. My goal is to verify the Pituitary Gland. Everything always points back to it.. including magnesium.. including LDN.. including Agmatine. I'm sure it's this gland that is the issue. Accutane must have wrecked it.
Can you guys clarify why Anastrozole causes joint pain? Ehohel, any sides you can attribute to MK-677. I've been getting ready to order some, but it doesn't seem completely devoid of sides, is it? How do you feel about this SARM at the moment? I don't have any new supplement or protocol to try besides MK-677, so that will be next. I feel like I'm already taking all the supplements I should. Diet is top notch. Gym performance is at its best yet. I still have many issues, but this right now is a definite improvement from June this year. Main cloud over my head is my T levels, and how hard it is to obtain a proper body composition. Working on it.
I'm reintroducing Creatine. I had never noticed it increased DHT. I've been reading so much I somehow blocked this fact from my mind. I recently supplemented some EGCG, as I had done in 2013, and somehow, I feel it made things worse. I read a bit on it and... it's a 5-ARI. Of course.
https://fr.scribd.com/document/270850865/5-alpha-reductase-inhibitor-pdfLastly, there's one thing I can't seem to understand. Why is Zinc recommended among us? I've yet to try supplementing Zinc, but isn't it a 5-ARI too? What's good about it?
There's nothing but benefits from long term growth hormone release, also mk-677 isn't a SARM honestly you won't see many benefits from buying a gram of it, it's much better on the long term. And the joint pain I'm feeling from anastrozole is from too much estrogen suppression, so I just gotta lower dose, find my sweet spot. Look up low estrogen side effects, joint pain is one of them. Also another side effect from anastrozole (probably from natural testosterone levels rising) is that my acne is coming back up. This REALLY REALLY sucks, perhaps I should try taking something like accutane to take care of that. oh wait.....
On 12/30/2016 at 10:16 AM, ACCUiTy_drANE said:So to add to some of the recent optimism, I've been having some success with my latest regimen.Magnesium Citrate (400 mg per day) + Low-dose Naltrexone (4.5 mg per night) has put my IBS in 90-95% remission. This regimen has worked better than any dietary intervention I have ever tried. This includes years of being gluten-free, dairy-free, and taking probiotics. The Magnesium actually does a lot by itself to curtail the bloating, gas and incomplete elimination. But LDN seems to make things a little better. I still feel a bit off in the mornings, but my embarrassing symptoms are no longer hanging over my head whenever I'm around people. I have stopped stressing about diet recently, as these supplements work better than literally anything.
Low-dose Naltrexone (4.5 mg per night) + Agmatine (2 grams per day) has also put a large dent in my anhedonia. Mentally, I feel 50-60% better. For the past two weeks, I have been feeling some reignited excitement for my hobbies. I actually feel capable of enjoying things, rather than looking at every activity as a mere distraction. I know something is up when I am actually looking forward to seeing people and engaging in hobbies. Sleep is better as well. What's interesting is that all of these substances have tolerance-reducing properties. They appear to work by upregulating your naturally occurring receptors. Agmatine (metabolite of L-Arginine) is said to reset one's tolerance for opioid medications and stimulants, partially through NMDA antagonism. LDN upregulates and sensitizes endogenous endorphin receptors, in addition to increasing endorphin production.
I know I will still get in a rut and progress won't always be linear, but in the last two weeks, 12 of those days have been pleasurable. Usually, I only have one-two days per fortnight in which my anhedonia is low. It seems I am more resilient to stress. In the future, I plan on looking into trying similar compounds such as Memtantine, which is also a NMDA antagonist like Agmatine. We know Memantine has effects on the immune system (as does LDN), and I suspect Agmatine does as well. Not to mention, Magnesium regulates NMDA receptors. I encourage people to research this angle given my profound results.
I really want to continue memantine cause of the nmda antagonism. But god does this brain fog kill, I think I just gotta suck it up and and feel dead inside for a couple weeks to get it going, I'm glad that LDN is lifting your anhedonia. How long is it that you're taking it now? I feel like estrogen suppression did lift my anhedonia quite a bit, but not completely. I'm thinking perhaps because following my accutane course I had a rough period of abusing adderall to be functional. Hopefully this isn't the case, but maybe I'll start up my LDN that has been sitting in a drawer for a while.
13 hours ago, ACCUiTy_drANE said:I'm aware that Glycinate is touted as superior, but Citrate is a perfect balance between cost and bioavailability. Also, the mild laxative effects are likely part of the reason it is so beneficial to me. Now, Oxide is pure trash in comparison.
The theory goes that some of us are low in DHT and some of us are high. If you're high, Zinc is theoretically better. If you're low, Creatine is theoretically better. I'm not sure I believe that either compound would be particularly beneficial, but I'm open-minded. Zinc is a pretty weak 5-ARI though. However, I generally avoid any other isolated compounds that are 5-ARI, including things like medicinal mushroom extracts. Whole foods are probably fine though.Creatine reliably causes me to break out, which isn't necessarily a bad thing. If anything, that shows it probably does impact my DHT. I would have to experiment again (for a sustained period of time) to know if it helps my cognition/anhedonia.
Thanks for clarifying. I guess zinc really isn't for me then. Dry skin, haven't lost a single hair in years. I'll go on with Creatine for now. Oddly, it's very hard for me to think about taking it, because it's not in pills. I'll make an effort and see what gives. Good if you know your magnesium, I guess Citrate makes sense in this case ^^
1 hour ago, ehohel said:There's nothing but benefits from long term growth hormone release, also mk-677 isn't a SARM honestly you won't see many benefits from buying a gram of it, it's much better on the long term. And the joint pain I'm feeling from anastrozole is from too much estrogen suppression, so I just gotta lower dose, find my sweet spot. Look up low estrogen side effects, joint pain is one of them. Also another side effect from anastrozole (probably from natural testosterone levels rising) is that my acne is coming back up. This REALLY REALLY sucks, perhaps I should try taking something like accutane to take care of that. oh wait.....
I shouldn't, but that last line made me laugh quite a bit. In regards to MK-677 sides, I was going off the wikipedia that provides some info on the effects of excess GH. https://en.wikipedia.org/wiki/Growth_hormone
I'll order MK-677 soon, definitely over a month's worth. I'll need to read more on Anastrozole, but I'll look into maybe having some by the end of January. I'm soon receiving 100ml of 5% Iodine. I'll get to experiment with higher dosages of 50-100mg. I've been without Iodine for over a week now, and I'm again beginning to require more and more sleep. I hate feeling the need to nap constantly.
1 hour ago, Kynarr said:Thanks for clarifying. I guess zinc really isn't for me then. Dry skin, haven't lost a single hair in years. I'll go on with Creatine for now. Oddly, it's very hard for me to think about taking it, because it's not in pills. I'll make an effort and see what gives. Good if you know your magnesium, I guess Citrate makes sense in this case ^^I shouldn't, but that last line made me laugh quite a bit. In regards to MK-677 sides, I was going off the wikipedia that provides some info on the effects of excess GH. https://en.wikipedia.org/wiki/Growth_hormone
I'll order MK-677 soon, definitely over a month's worth. I'll need to read more on Anastrozole, but I'll look into maybe having some by the end of January. I'm soon receiving 100ml of 5% Iodine. I'll get to experiment with higher dosages of 50-100mg. I've been without Iodine for over a week now, and I'm again beginning to require more and more sleep. I hate feeling the need to nap constantly.
Those sides are from basically a broken pituitary gland. I bet you'd have to inject quite a bit of real HGH for them to come up as well. I highly doubt a growth hormone secretagoguecan cause that much GH release. MK-677 just stimulates your own pituitary gland, not like we're actually using synthetic HGH.
8 hours ago, ehohel said:I really want to continue memantine cause of the nmda antagonism. But god does this brain fog kill, I think I just gotta suck it up and and feel dead inside for a couple weeks to get it going, I'm glad that LDN is lifting your anhedonia. How long is it that you're taking it now? I feel like estrogen suppression did lift my anhedonia quite a bit, but not completely. I'm thinking perhaps because following my accutane course I had a rough period of abusing adderall to be functional. Hopefully this isn't the case, but maybe I'll start up my LDN that has been sitting in a drawer for a while.
I am going on my second month of LDN now. Yeah, I used Adderall for seven months at 2-3 times per week a while after quitting Accutane. The focus was nice, but it killed my mood. It also seemed to blunt my response to Caffeine, which has traditionally been a great booster for me. I haven't touched Adderall in 10+ months now, and the magic of Caffeine is returning again. The fact I am taking 4 different compounds with tolerance-reducing properties probably helps too. But Caffeine seems to have potent antidepressant effects for me, which interestingly show up several hours after dosing. As long as I keep my Caffeine usage intermittent, it's been a reliable pick-me-up for three years now.
If Memantine is too much, just try Agmatine. There are lots of anecdotes on /r/depressionregimens of it helping people. As far as I know, the evidence for Memantine as an antidepressant is weak anyway, but it seems to help some people significantly when it does work. FYI, IRC.BIO now carries Naltrexone as well as an anti-inflammatory called Ibudilast. Some people claim it helps brain fog, so I'll probably be trying it.
4 minutes ago, ACCUiTy_drANE said:I am going on my second month of LDN now. Yeah, I used Adderall for seven months at 2-3 times per week following Accutane. The focus was nice, but it killed my mood. It also seemed to blunt my response to Caffeine, which has traditionally been a great booster for me. I haven't touched Adderall in 10+ months now, and the magic of Caffeine is returning again. The fact I am taking 4 different compounds with tolerance-reducing properties probably helps too. But Caffeine seems to have potent antidepressant effects for me that show up several hours after dosing. As long as I keep my Caffeine usage intermittent, it's been a reliable pick-me-up for three years now.If Memantine is too much, just try Agmatine. There are lots of anecdotes on /r/depressionregimens of it helping people. As far as I know, the evidence for Memantine as an antidepressant is weak anyway, but it seems to help some people significantly when it does work. FYI, IRC.BIO now carries Naltrexone as well as an anti-inflammatory called Ibudilast. Some people claim it helps brain fog, so I'll probably be trying it.
Yeah my ibudilast came in today, I feel shot awake on it, going to see if it gets better with continuous use. And I'm gonna continue the memantine, might as well as I already have it.
3 hours ago, Nicholas Ross said:Your hair loss could be due to stress.
thanks for your reply
no im happy all the time , and im losing like 500 hairs a day im really scared to go bald im just 19 , no one in my family is bald not a single one , i will do or pay any amount to any one who can help im so sad about my hair