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7 hours ago, Weltschmerz47 said:I tried anastrozole.. definitely felt better on it, probably by far most successful thing I've tried thus far, but did not last more than a few weeks after stopping
That's what made me positive this is hormonal like a yr ago. Weightlifting is probably the second most successful thing I've tried.. the more muscle you put on, the more permanent improvement you create
Currently trying Sustain Alpha. Extremely positive results so far.. I suggest you try that before pharmaceuticals
Are you using these type of agents because you have high Estrogen? I'm just wondering how this would all go down with someone with normal E2.
8 hours ago, Weltschmerz47 said:I tried anastrozole.. definitely felt better on it, probably by far most successful thing I've tried thus far, but did not last more than a few weeks after stopping
That's what made me positive this is hormonal like a yr ago. Weightlifting is probably the second most successful thing I've tried.. the more muscle you put on, the more permanent improvement you create
Currently trying Sustain Alpha. Extremely positive results so far.. I suggest you try that before pharmaceuticals
How long did you continue it at what dosages? If I recall correctly the fin guy took it for many months slowly tapering the dosage down and he claims a full recovery. I have enough to last me about 6 months. I feel so good today, head is really clear, I can gather my thoughts, plan my day, no zombie feeling.
@HideAndSeek So sorry to hear your sides are back. That must be frustrating. Definitely don't take an anti-depressant, unless your doctor will give you a prescription for an older generation one. The SSRIs that they give now have many of the same side effects that Accutane does. (Just google PSSD - that's "post-SSRI Sexual Dysfunction). They also come with depersonalization, lack of motivation, and a host of other psychological side effects. My family has actually been more damaged by an SSRI than by Accutane. Someone else earlier mentioned Effexor - that's the worst of the worst.
But, perhaps an older generation anti-depressant, if your doc is willing - here's a story of a guy who had PSSD and believes he cured himself with a trycyclic anti-depressant. Worth looking into....
@hatetane I think there's something to the comment that you made earlier about using a daily dose of Cialis. At least it would keep the irculation going and avoid the penis becoming atrophied. I keep thinking, that much of the ED has to do with inflammation - those tiny tubes for transporting nitric oxide would not take much inflammation of the tissues surrounding to block them off completely.
Regarding the whole post-chemo conversation - my mother has had four bouts of cancer and has been treated with chemo and radiation each time. She's past all the cancer now, hopefully, and still hasn't felt well for months post-chemo. But when I can get her to drink it, CBD water does make her feel much better. One of it's most beneficial uses is as an anti-inflammatory.
@tanedout My son also did not tolerate the high well from the RSO. He didn't get anywhere near the full number of grams that the others claim is necessary for a full recovery, but he has had considerable improvement in his ED. We read a story online about a man who cured his cancer with RSO while working full time and caring for his children in the evenings. He just took the full day's amount about 30 minutes before bedtime. Then when he started to get the high, he went to bed and slept it off.
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Sorry for two posts in a row - it's a catch-up day.
Kudos to you all for the great strides you are making! Whoever figured out that there may be two types of sufferers deserves a Nobel prize. If it's true, it narrows by half the things to try.
So, I need some advice. My son is on break from university now and is anxious to feel better. I think the RSO resolved his ED enough that he's satisfied with it where it is. Maybe not quite where he was pre-tane, but seems to feel good knowing that the complete cure is in the fridge if he decides he needs it.
He has been cycling zinc as someone suggested earlier. Not so much for the sexual sides, but just because he needs to feel better in general.
I ordered quite a lot of calcium d glucarate and also glucuronolactone. Those of you who've been using them, can you give me some tips on how much, how long, together or separate, etc? Is there some consensus on what works? When he had his last blood test, his bilirubins were 1.5 ml/dl (acceptable range .2-1.1) so I'm hoping the liver detox part will help. We were thinking about the liver cleanse, but, well, ick. Also, the liver cleanse with apple juice, olive oil, etc. seems to get mixed reviews?
Also, should he totally stop the zinc for awhile before starting the CdG and/or gluc?
On 12/17/2016 at 1:19 PM, Weltschmerz47 said:Currently trying Sustain Alpha. Extremely positive results so far.. I suggest you try that before pharmaceuticals
What sort of benefits are you seeing from the sustain alpha, improved libido, less ED? I see a lot of the PFS guys have gone down the pro-hormones route with Andro Hard etc, and some have got good results. I think for me this will probably be the next thing to try, unless I can get hold of Anastrozole.
On 12/18/2016 at 2:12 AM, Justmom said:@tanedout My son also did not tolerate the high well from the RSO. He didn't get anywhere near the full number of grams that the others claim is necessary for a full recovery, but he has had considerable improvement in his ED. We read a story online about a man who cured his cancer with RSO while working full time and caring for his children in the evenings. He just took the full day's amount about 30 minutes before bedtime. Then when he started to get the high, he went to bed and slept it off.
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i took it only before bed, and did this for almost 6 months, but I still found I would often wake in the middle of the night with a pounding heart beat, or wake up for work the net morning stoned. This was on a fraction of the recommended dose - I think I got through 5-10g in 6 months, when the recommendation is building up to 1g per day or more. I researched this quite heavily beforehand and chose a strain with high THC and high CBD, as apparently the CBD actually counteracts the effects of the THC, but it still got me too smashed, so gave up in the end.
Did experience some benefits, but nothing lasting unfortunately. I'm pleased to hear your son has seen some benefits though, and it may be worth checking out the strain to find out what the THC/CBD ratio is and see if he can tolerate a different strain with higher CBD.
I think the likely benefit of it is down to it being a DHT inhibitor though (also increases dopamine, but likely this is temporary). Worth mentioning though around the time I went down this route I was conversing with a couple of others on this forum who also tried it, and none of us got lasting results from it, but there are at least 3 who have recovered via this route (the only 3 convincing recoveries from tane sides on this thread as it happens)
BPS's website is extremely basic with half the links not working, and no information about the company. Not confidence inspiring.
With OTC you never truly know whats in the product. There's also a liquid version called res-100 here in Aus , but all the threads pushing that are inundated with guy actually selling it. I did read positive reviews but also a thread where a bunch of people said it did nothing. Worth a try I guess if you have mild elevated oestradiol , but there are other supplements I'd try instead like DIM. Resveratrol itself also acts as an oestrogen agonist.
15 hours ago, mikez said:Are you using these type of agents because you have high Estrogen? I'm just wondering how this would all go down with someone with normal E2.
Please be careful guys. Some of you maybe have very low E (fact) Low E can be just as detrimental as high E.
Check my previous posts and see the video I posted of Nelson Vergel.
Also I received this from a leading doctor. I have really looked at low E and I haven't really found much info on it so if any of you can post
anything you find that would be really useful.
You guys in Aus - do you get given a lower range. Most GP's think that the lower the E for a male the better and with no lower range given here it suggests that zero E is ok.
Well with much research I have found that this is not the case but the our GP and endo have both ignored low E.
This from a leading doctor. Sorry I am unable to reference it.
I would really appreciate any comments on this.
Some of you have already posted you E level but can you post range and if anyone else has been tested please post.
On 12/17/2016 at 4:36 AM, mikez said:Your E2 is a bit high actually. Naturally, if you are converting too much T, you are right, it should raise T. What dose are you using?
I got confused for a sec as here in Aus, we use different units. Itested 60 most recently, but its pmol/ml which is only 16 pg/ml. Your '37' I'm assuming is in pg/ml?
Thats great you are feeling better as its way easier to take than many other things.
Best of luck.
Also wondering, did you happen to try Clomid for any reason in the past?
What do you think of 18 pmol? please PM me
9 hours ago, Justmom said:Sorry for two posts in a row - it's a catch-up day.
Kudos to you all for the great strides you are making! Whoever figured out that there may be two types of sufferers deserves a Nobel prize. If it's true, it narrows by half the things to try.
So, I need some advice. My son is on break from university now and is anxious to feel better. I think the RSO resolved his ED enough that he's satisfied with it where it is. Maybe not quite where he was pre-tane, but seems to feel good knowing that the complete cure is in the fridge if he decides he needs it.
He has been cycling zinc as someone suggested earlier. Not so much for the sexual sides, but just because he needs to feel better in general.
I ordered quite a lot of calcium d glucarate and also glucuronolactone. Those of you who've been using them, can you give me some tips on how much, how long, together or separate, etc? Is there some consensus on what works? When he had his last blood test, his bilirubins were 1.5 ml/dl (acceptable range .2-1.1) so I'm hoping the liver detox part will help. We were thinking about the liver cleanse, but, well, ick. Also, the liver cleanse with apple juice, olive oil, etc. seems to get mixed reviews?
Also, should he totally stop the zinc for awhile before starting the CdG and/or gluc?
HI, It's so good to hear from you again and great that your son has made some recovery.
13 hours ago, mikez said:BPS's website is extremely basic with half the links not working, and no information about the company. Not confidence inspiring.
With OTC you never truly know whats in the product. There's also a liquid version called res-100 here in Aus , but all the threads pushing that are inundated with guy actually selling it. I did read positive reviews but also a thread where a bunch of people said it did nothing. Worth a try I guess if you have mild elevated oestradiol , but there are other supplements I'd try instead like DIM. Resveratrol itself also acts as an oestrogen agonist.
I've read that Res-100 is extremely effective, and if you look at products like Sustain Alpha and Androhard etc, they all contain reservatrol as an AI, just like res-100 does.
DIM did nothing for me either actually, Erase Pro is a fairly effective herb AI which I got some benefits for taking it for a few months, but nothing lasting. Something stronger is clearly required.
5 days intoAnastrozole, 7 days into mk-677.
Safe to say my head is the clearest it's ever been, systematic inflammation has been totally eliminated, sleeping like a baby, depression is minimal. All that's left is to continue for a while, and hope that these effects don't subside upon discontinuation.
A couple questions: 1- what is the most someone has recovered from accutane depression and loss of personality?
2-who else is on anti depressants?
3-Who here has been hospitalized over depression/suicide attempts?
4-what is the best way to deal with bowel problems, or am I pretty much fucked there?
16 hours ago, tanedout said:I've read that Res-100 is extremely effective, and if you look at products like Sustain Alpha and Androhard etc, they all contain reservatrol as an AI, just like res-100 does.DIM did nothing for me either actually, Erase Pro is a fairly effective herb AI which I got some benefits for taking it for a few months, but nothing lasting. Something stronger is clearly required.
Sorry, I meant IC3 not DIM. But like you said, if you want real results, you need the real thing. I read a lot of threads saying Res-100 is effective as well as sustain alpha, but also some threads saying both did nothing. The thing that worried me is this guy 'ON' who sells res-100 was literally on every thread providing the feedback and flaming anyone who said anything bad. Also , resveratrol is a mixed antagonist/agonist at E2 receptors.
13 hours ago, ehohel said:5 days intoAnastrozole, 7 days into mk-677.
Safe to say my head is the clearest it's ever been, systematic inflammation has been totally eliminated, sleeping like a baby, depression is minimal. All that's left is to continue for a while, and hope that these effects don't subside upon discontinuation.
Thats great news...can you remind me what your E2 levels were at?
16 hours ago, ehohel said:5 days intoAnastrozole, 7 days into mk-677.
Safe to say my head is the clearest it's ever been, systematic inflammation has been totally eliminated, sleeping like a baby, depression is minimal. All that's left is to continue for a while, and hope that these effects don't subside upon discontinuation.
A couple of things:
Has it improved excess sweating?
Has it had an effect on overall dryness in the body?
Has is improved thinning hair, thin skin etc?
All these things that feel permanent, have you noticed an improvement in these areas too??
6 hours ago, TrueJustice said:A couple of things:Has it improved excess sweating?
Has it had an effect on overall dryness in the body?
Has is improved thinning hair, thin skin etc?
All these things that feel permanent, have you noticed an improvement in these areas too??
Can't comment on sweating, not really an issue for me.
Dryness feels the same, but then again I'm not extremely dry to begin with. Feels like my body is using water again though. Used to be that I drink water and piss clear water, now every pee is really yellow, dunno how that's related.
Never noticed not thinning on my end so can't comment here either.
I have some mild wrist discomfort today so I'm going to drop to 0.5mg from now on.
9 hours ago, TrueJustice said:A couple of things:Has it improved excess sweating?
Has it had an effect on overall dryness in the body?
Has is improved thinning hair, thin skin etc?
All these things that feel permanent, have you noticed an improvement in these areas too??
Bet you've got low DHT (compared to high for me). I virtually don't sweat at all since getting tane sides. Things that make me feel a bit better, i.e. DHT inhibitors, and also TUDCA, make me sweat again and I again start to get sweat patches under my arms again when doing something physical. Also regards the dryness, I'm again the exact opposite - my skin is incredibly oily all the time and some days I'll wash my face a couple of times as it looks shiny with all the oil.
Try things that boost DHT - take creatine, lift weights
15 hours ago, cnb30 said:A couple questions: 1- what is the most someone has recovered from accutane depression and loss of personality?
2-who else is on anti depressants?
3-Who here has been hospitalized over depression/suicide attempts?
4-what is the best way to deal with bowel problems, or am I pretty much fucked there?
Give kefir milk a go for gut issues - some people have healed chrones using that. You can get the grains off eBay and use organic whole milk, or 'raw' milk. Bet you'll feel better a month of that. I think shilajit helps the gut too as it's a good source of fulvic acid. Get a decent brand as the cheap stuff can be high in heavy metals.
@tanedoutI don't sweat and my face skin is very dry. Where does that leave me? Getting DHT tested is not currently an option. I take creatine and lift weights.
@JustmomI was dosing 3g CdG per day. I'd recommend 1g three times a day as it clears the system within 5 hours. I felt much, much better on it. Most of my IBS symptoms had gone away. Skin was less dry, and I felt in a better place mentally. I'm not sure if I've kept its benefits now that I'm done with this trial. I haven't taken any for two months. I took a total of 90g. I suggest you look at my post history as I wrote quite a bit on it.
As for glucuronolactone, I haven't played much with it. I'm not even sure if it acts the same, though from what I've read it's safe to take in higher dosages too, especially as it's calcium-free. I will experiment again with these two compounds later down the road, but despite feeling better, I believe these helped convince me that we are not dealing with a vit A toxicity issue. At least not primarily.
4 hours ago, tanedout said:Bet you've got low DHT (compared to high for me). I virtually don't sweat at all since getting tane sides. Things that make me feel a bit better, i.e. DHT inhibitors, and also TUDCA, make me sweat again and I again start to get sweat patches under my arms again when doing something physical. Also regards the dryness, I'm again the exact opposite - my skin is incredibly oily all the time and some days I'll wash my face a couple of times as it looks shiny with all the oil.Try things that boost DHT - take creatine, lift weights
Give kefir milk a go for gut issues - some people have healed chrones using that. You can get the grains off eBay and use organic whole milk, or 'raw' milk. Bet you'll feel better a month of that. I think shilajit helps the gut too as it's a good source of fulvic acid. Get a decent brand as the cheap stuff can be high in heavy metals.
Good info!!
Having recently finished up my visits to the gastroenterologist where he concluded I don't have a gut issue, I believe he's right in that I don't not have anything sinister going on but try getting info out of these guys on basic gut maintenance and they offer nothing!! They are helpful if you have something serious to deal with but forget it if you mention probiotics or kefir etc - they're a closed book if you start asking questions about healthy flora etc and how to better your gut health. You'll get more off this forum and save yourself the $180 bill.
Even if you aren't a tane victim, people need to do more to have a healthy gut, it's pretty much where good health starts when you think about it.
23 hours ago, Kynarr said:@JustmomI was dosing 3g CdG per day. I'd recommend 1g three times a day as it clears the system within 5 hours. I felt much, much better on it. Most of my IBS symptoms had gone away. Skin was less dry, and I felt in a better place mentally. I'm not sure if I've kept its benefits now that I'm done with this trial. I haven't taken any for two months. I took a total of 90g. I suggest you look at my post history as I wrote quite a bit on it.As for glucuronolactone, I haven't played much with it. I'm not even sure if it acts the same, though from what I've read it's safe to take in higher dosages too, especially as it's calcium-free. I will experiment again with these two compounds later down the road, but despite feeling better, I believe these helped convince me that we are not dealing with a vit A toxicity issue. At least not primarily.
@Kynarr Thank you so much, Kynarr, for the advice. He started at lunch today on only the CdG. He will stick to your suggestion of the 1g 3x per day and hold off on the glucunolactone for now.
I'm a bit confused by your second paragraph, though. Doesn't CdG clear toxins from the liver, vitamin A amongst them?
Has anyone tried L-Lysine along with anything else? It is on a couple of lists of DHT blockers, not as a DHT blocker, but as a product that enhances them.
@JustmomIt should, at least according to what I read on https://en.wikipedia.org/wiki/Glucuronidation , however I did not feel that the symptoms which I thought were caused by Vit A toxicity improved all that much. It's a tough call. Maybe I didn't take enough CdG. Maybe the body just doesn't flush vit A as we'd like it too. Maybe we're no longer dealing with vit A toxicity years down the road. In any case, my perspective right now is that it's not as simple as treating a vit A toxicity. I still have it in mind to attempt other supplements that in theory flush vit A, but I'm busy trying other things for now, and I've already tried vit E, Taurine, Thiamine, vit K, CdG.. I know there's others such as Chlorophyll I believe, but I don't put much faith in it.
See I've tried MK-2866, but now we have @ehoheltrying MK-677, which impacts IGF-1. I still have the FoxO1 theory I've yet to attempt myself. I believe if ehohel's condition indeed improves, then it likely has nothing to do with Anastrozole, and more so with MK-677.
I don't have much on the IGF-1 theory except this:
The idea:
Issues from accutane stem from increased FoxO1 gene activity. The transcription of FoxO genes is stimulated by FoxO3 and repressed by growth factors like insulin and insulin-like growth factor-1 (IGF-1) which are increased in puberty and acne-associated syndromes with insulin resistance. By increasing IGF-1 levels, we can reduce FoxO gene activity and establish a proper balance.
Accutane leads to a reduction in IGF-1 levels.
Proper IGF-1 levels would help with:
Facial sebum production
Testosterone levels
Positive, stable mood.
Thiamine/Benfotiamine (B1) and NAD+ (B3) would also reduce FoxO1.
Sources
Isotretinoin and FoxO1 - very in depth, also discusses Lithium.
Comparison of retinoid-induced apoptosis in various cell types
http://www.allthingsmale.com/community/threads/official-accutane-thread.20097/page-26 Official Accutane Thread
Kynarr's post just gave me some insight into why the pilocarpine drops are working for me. The Fox O1 genes, which seem to be upregulated by isotretinoin and it's metabolites, are dystegulated by insulin. The pilocarpine is an M3 Muscarinic acetylcholine agonist and the pancreas has many of these receptors which modulate glucose homeostasis and insulinsecretion. It may not be specifically reversing isotretinoin effects, but atleast it may be counter-acting them, and for a significant duration. I just took another dose a few days ago and oddly it seems even more potent. The first time it took several doses over the course of 72 hrs for me to notice the reduction of all my symptoms.
Results are in.
Total T: 434 (15nmol/L)
SHBG: 47 nmol/L
Prolactin: 7 ug/L
FSH: 2.4 Ul/L
LH: 1.1 Ul/L
PSA: 0.83 ug/L
Estradiol: Missing from the results.
SHBG is down by 3. Total T is down from 505by a lot, considering how hard I've been trying to increase it. PSA is up from 0.65.
So that's the results of 6 months of intensive research and experiments with CdG, Iodine, MK-2866, vit K, magnesium, LongJack, DIM, vit C..
Funny thing, on the PSA results, there's a paragraph about 5-ARI caused by drugs such as finasteride and accutane, and that the reference range needs to be cut in half. They're rubbing it in my face I swear haha.
I'll be honest, I don't know what to do anymore. I'm actually crying. I try to be optimistic, but I feel I'm screwed no matter what I try. On to Testosterone therapy for the rest of my life..