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4 minutes ago, TrueJustice said:What did you notice??Increased energy
more moisture in skin
less joint pain
thicker hair
better night visionI could go on........
It's an experimental antidepressant, with permanent effects.
4 minutes ago, ACCUiTy_drANE said:The relationship between NSI-189 and its therapeutic effects are on a bell curve. More is not necessarily better, but self-experimentation may be needed to find the perfect dose. I generally stayed away from dosing under the tongue (sublingual), because it introduces an unknown. On one hand, sublingual dosing may make it so a lower dose is needed to achieve optimal effects. But on the other hand, because we don't know how sublingual dosing impacts absorption for this particular substance, it may make dosing more confusing.
Yeah, don't follow my steps. It's already a possibly dangerous drug in the long term(we don't know yet), so don't make it even more potentially dangerous by not following the method the trials are using. (oral phosphate)
On 9/28/2016 at 5:59 PM, MonsterDiesel said:I used B12 and folate before with no benefit. It's only after I added 500 mg Methionine a day, that I saw improvement in my crippling depression and fatigue. The effects are not cummulative though. If I don't take all 3 first thing in the morning, all those problems come back.
I think I'm going to recant this statement. While it is true that methionine/b12/folate eliminated my fatigue completely, it also put me in a state of overmethylation and completely killed my libido. In addition, I've been feeling anhedonic and very depressed lately. (Low dopamine from too much COMT activity?)
7 hours ago, MonsterDiesel said:I think I'm going to recant this statement. While it is true that methionine/b12/folate eliminated my fatigue completely, it also put me in a state of overmethylation and completely killed my libido. In addition, I've been feeling anhedonic and very depressed lately. (Low dopamine from too much COMT activity?)
Your post got me curious about Methionine, how would this aid again with fatigue?
My understanding is it helps with liver detox. I understand that with any successful detox might come increased energy but you could argue water aids in detox but I don't link water with fighting fatigue.
Just not sure how methionine would aid fatigue directly?
thx for update
Id also like to ask - for those currently taking LDN did you not have any luck with the Mthionine/B12/Folate combination??
Folate which I've yet to take apparently is very helpful in treating depression by helping the body release serotonin.
Id like to try the above combination before LDN but would like hear from those who've tried it.
Im guessing the LDN users will say been there, done that and it didn't work!?
There are a couple of mail-order telomere tests available. The test by Teloyears ([removed]) uses a blood sample and is $89, while the one by Titanovo, using saliva, is $150. Does anyone know if one of these is known to be better, or if there's a reason to get the more costly test?
Sorry my video is quite shitty and hardly shows anything, I was exhausted today after work and wasn't thinking straight while making it.
Basically, ceretropics vials do fit 10mL. So a full 1mL syringe will give you 10mg. And you can cut that into two doses (what I'm doing) daily. So half a syringe (0.5mL) twice a day = 5mg per injection (10mg per day). I will edit this post once it's done uploading. Feel free to ask me any questions if you're confused about something, as I said the vid is poor quality.
edit:
6 hours ago, john86 said:There are a couple of mail-order telomere tests available. The test by Teloyears (www.teloyears.com) uses a blood sample and is $89, while the one by Titanovo, using saliva, is $150. Does anyone know if one of these is known to be better, or if there's a reason to get the more costly test?
Im just curious on what you will do with the info anyway??
What will be your next move if a test did prove your telomeres were indeed shortened?
Just a question and I somewhat believe that Accutaneacceleratespremature aging....however, I am not sure if the telomeres test is useful unless you would have had it before Accutane to compare after taking Accutane. Just a thought????
Or is it more a test that they do based on your age and where your telomeres should be?
On 11/4/2016 at 10:15 PM, ehohel said:Damn it, got my epitalon today, but my telomeres test wont be here till Monday.
Great, someone with a brain.
Test before you try and supplement or tweak/repair.
Ideally everything would have been tested before taking accutane - too late now.
Keep testing and posting - it is the only way to help others.
I have seen a couple of people say their telomeres seem to have been shortened after accutane.
I corresponded with an expert in the US. He says they have the knowledge to lengthen telomeres
but finance is needed to get it approved etc.
I found him on youtube.
Be interesting to see how you get on with epitalon.
On 7.11.2016 at 6:29 AM, TrueJustice said:Id also like to ask - for those currently taking LDN did you not have any luck with the Mthionine/B12/Folate combination??Folate which I've yet to take apparently is very helpful in treating depression by helping the body release serotonin.
Id like to try the above combination before LDN but would like hear from those who've tried it.
Im guessing the LDN users will say been there, done that and it didn't work!?
Try for depression 5-htp. I have some success with it.
8 hours ago, oli girl said:Just a question and I somewhat believe that Accutaneacceleratespremature aging....however, I am not sure if the telomeres test is useful unless you would have had it before Accutane to compare after taking Accutane. Just a thought????
Or is it more a test that they do based on your age and where your telomeres should be?
I am doing it before epitalon to see what age my telomeres currently represent, and I will take it again maybe a month or two after epitalon to see any difference.
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I would like to note that the NA version of epitalon has still not fully dissolved, still sort of "chunky", sort of a pain in the ass for injection. I will add another mL today to the current 90mg and see if it will help.
my first day was 5mg, can't say I've noticed anything yet.
On 11/7/2016 at 11:47 PM, TrueJustice said:Im just curious on what you will do with the info anyway??
What will be your next move if a test did prove your telomeres were indeed shortened?
Aside from trying Epitalon, in which case you'd want to test them before and after no matter what, I suppose the only other reason is that it might be insightful, in and of itself, if it shows that after Accutane your telomeres were extraordinarily shortened; like if Accutane caused you to have the telomeres of someone twice as old. But if you're suggesting that it probably isn't that useful, you're probably right in most cases. Though, I personally am not opposed to trying the obscure Russian peptide if I can find more evidence of its effectiveness, I'll hold off for now since I'm trying NSI-189 and don't wish to introduce any confounding variables.
18 hours ago, john86 said:Aside from trying Epitalon, in which case you'd want to test them before and after no matter what, I suppose the only other reason is that it might be insightful, in and of itself, if it shows that after Accutane your telomeres were extraordinarily shortened; like if Accutane caused you to have the telomeres of someone twice as old. But if you're suggesting that it probably isn't that useful, you're probably right in most cases. Though, I personally am not opposed to trying the obscure Russian peptide if I can find more evidence of its effectiveness, I'll hold off for now since I'm trying NSI-189 and don't wish to introduce any confounding variables.
I think epitalon would poentiate nsi. Anyways I'm taking both, I'll let you know if I die.
Looking at depression specifically as a side effect after tane, does anyone have any theories on how this might come about?
Do we think it's due to brain damage or an upset in gut health? Could it be due to liver damage, I just don't know?
Im just at a point where all these detoxes, gut remedies, antibiotics etc do nothing. Im thinking of going back on an antidepressants or at least looking at things that address brain health more directly cause everything else isn't working!!
There are so many variables, but I personally think its damage within the brain, to the hippocampus, or maybe pineal. I haven't looked extensively into Dr. Bremner's research, but I plan on getting a Spect scan one day. I should probably see what his findings are before referencing him, just haven't put in the time. It's also hard to drag oneself to have this kind of conversation with a doctor, because as soon as you do, it's permanently on your record. Insurance companies and employers, anyone has access to your medical files these days, despite what bullshit they tell you. It's really not fair and a catch 22 to those who are affected by pharmaceuticals.
Accutane, a controlled extended period retinoid toxicity, has proven to shrink and sequester sebaceous glands, which are microscopic exocrine glands within the body. I've read in scientific studies that Isotretinoin has the ability to make cancerous cells appear Normal, which I don't quite understand, but apparently it is why it is given in combination with chemotherapy. So we know it has some type of cellular effect. Cells make up everything in us essentially. Sebaceous glands are exocrine glands. There are both exocrine and endocrine glands throughout the body and brain. Does a chemical have the ability to discern between them? I don't think so. I think in highly sensitive people it shrunk and impacted multiple glands both exocrine and endocrine, permanently. The same reason one permanently loses their acne after this "treatment" (for the most part).
Thx for response!!
I was on my last day today of taking the apple juice doing the whole liver cleanse thing, had a colonic yesterday etc and today I just went fuck it and ditched the whole liver cleanse idea, I mean I've done 6 of them and haven't noticed a thing - energy is fucked, muscles are sore, light sensitivity is still there, they clearly don't work in my case.
I just know my brain feels altered by tane as much as I hate to admit it - it actually feels like my brain is inflamed and this is still going on 20 years now, it's a fucking miracle I can even work and function. I'm constantly on the search for supplements and something that brings relief but it never comes - I've spent a fortune!!
You say "Spect scan", is that what you should have done over say an MRI or 'cat scan' in our case??
3 days remaining on my first bottle of epitalon. I don't know if I noticed anything obviously significant other than the best goddamn sleep I've ever gotten in my life, very refreshing sleep, I think I have more energy, not sure if that's directly from epitalon, or because of better quality sleep, or placebo.
hopefully the better effects kick in later too. I have ordered another bottle of epitalon, but this time without the admitate to see if I get better results (admitate doesn't work well on some people). Also because it absolutely refuses to fully dissolve, I've used a total of 12mL and it still has some snowflakes and I don't want to add more cause 0.61mL injections are already a fair amount of volume for 5mg.
The other versions should hopefully dissolve in like 7-8mL.
2 hours ago, ehohel said:3 days remaining on my first bottle of epitalon. I don't know if I noticed anything obviously significant other than the best goddamn sleep I've ever gotten in my life, very refreshing sleep, I think I have more energy, not sure if that's directly from epitalon, or because of better quality sleep, or placebo.
hopefully the better effects kick in later too. I have ordered another bottle of epitalon, but this time without the admitate to see if I get better results (admitate doesn't work well on some people). Also because it absolutely refuses to fully dissolve, I've used a total of 12mL and it still has some snowflakes and I don't want to add more cause 0.61mL injections are already a fair amount of volume for 5mg.
The other versions should hopefully dissolve in like 7-8mL.
When do you expect you'll have you first telomere length result? How old are you?