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Repairing the long-term damage from Accutane

 
MemberMember
960
(@tryingtohelp2014)

Posted : 11/01/2016 4:37 pm

7 hours ago, ehohel said:

For those with joint pain, I'm having excellent success with boron almost one week in. Keeps getting better daily.

how much are you taking.. brand?

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MemberMember
50
(@ehohel)

Posted : 11/01/2016 4:43 pm

16 minutes ago, tryingtohelp2014 said:
7 hours ago, ehohel said:

For those with joint pain, I'm having excellent success with boron almost one week in. Keeps getting better daily.

how much are you taking.. brand?

Trace Minerals (it's a liquid) taking 12mg daily split into 2 doses.

---

Considering our endocrine system is fucked. I found a peptide called Epitalon. I'm sort of interesting in eating the price and giving it a shot to see if it changes anything.

Check this out:

  • Telomerase activation (consequently, elongation of Telomeres)
  • regulates neuroendocrinous system
  • increases the hypothalamic sensitivity to the endogenous hormonal effects
  • decrease or suppression of proliferative changes in vaginal epithelium and endometrium in anovulatory phase
  • normalization of gonadotropic hormones levels (FSG, LG, prolactin)
  • positive influence on peripheral haemodynamics: improvement of blood rheology, decrease of intravessel thrombogenesis
  • regulation of the levels of reactants in the acute inflammation phase (c3-component of the complement, pre-albumin, C-reactive protein, alpha-orosomucoids
  • normalization of T-cell immunity
  • normalization of aqua-electrolyte balance indices
  • normalization of uric acid levels
  • normalization of Cholesterol
  • rejuvenation / strengthening of the immune system
  • inhibition of spontaneous and induced carcinogenesis (tumor prevention)
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MemberMember
223
(@gladiatoro)

Posted : 11/01/2016 5:09 pm

In my opinion this drug and its generic cousins needs to be banned from the general public just like VIOXXthat maimed /killed thousands of inocent victims .

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MemberMember
42
(@kynarr)

Posted : 11/01/2016 6:29 pm

On 11/2/2016 at 5:43 AM, ehohel said:

Trace Minerals (it's a liquid) taking 12mg daily split into 2 doses.

---

Considering our endocrine system is fucked. I found a peptide called Epitalon. I'm sort of interesting in eating the price and giving it a shot to see if it changes anything.

Check this out:

  • Telomerase activation (consequently, elongation of Telomeres)
  • regulates neuroendocrinous system
  • increases the hypothalamic sensitivity to the endogenous hormonal effects
  • decrease or suppression of proliferative changes in vaginal epithelium and endometrium in anovulatory phase
  • normalization of gonadotropic hormones levels (FSG, LG, prolactin)
  • positive influence on peripheral haemodynamics: improvement of blood rheology, decrease of intravessel thrombogenesis
  • regulation of the levels of reactants in the acute inflammation phase (c3-component of the complement, pre-albumin, C-reactive protein, alpha-orosomucoids
  • normalization of T-cell immunity
  • normalization of aqua-electrolyte balance indices
  • normalization of uric acid levels
  • normalization of Cholesterol
  • rejuvenation / strengthening of the immune system
  • inhibition of spontaneous and induced carcinogenesis (tumor prevention)

If you do, be sure to get your telomere length tested PRIOR to trying epitalon. I've yet to find a post-Accutane user report their telomere length prior to playing with it.

[Edited link out]

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MemberMember
50
(@ehohel)

Posted : 11/01/2016 7:38 pm

On 11/2/2016 at 7:29 AM, Kynarr said:

If you do, be sure to get your telomere length tested PRIOR to trying epitalon. I've yet to find a post-Accutane user report their telomere length prior to playing with it.

[Edited link out]

Yep, I think I will give it a go.

Edit: Am doing it, will update.

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MemberMember
158
(@accuity_drane)

Posted : 11/01/2016 8:55 pm

On 11/2/2016 at 5:43 AM, ehohel said:

Considering our endocrine system is fucked. I found a peptide called Epitalon. I'm sort of interesting in eating the price and giving it a shot to see if it changes anything.

I originally joined Acne.org to bring up this compound. I posted about it on AllThingsMale as well. [Edited link out]

TL;DR: Accutane's metabolite, All-trans Retinoic Acid (ATRA), appears capable of downregulating the telomerase enzyme. Epitalon can activate that exact enzyme. Telomerase is found in ADULT stem cells, which are relevant to repair functions throughout the ENTIRE body. This may explain the diversity of Accutane's side effects.

The problem is that Epitalon is sold in its "raw" form due its instability, so it is NOT shipped in a ready-to-insufflate or ready-to-inject form. If somebody made a video showing how to reconstitute Epitalon (specifically) into a nasal spray or injectable solution, I may embark on the Epitalon journey. I would also get my telomeres tested before and after using this compound.

I have a COMPLETE mental block whenever someone tries to explain to me (with words) how to reconstitute compounds and get the dosing correct based on the reconstitution. I would need a video that shows it step-by-step, because dosing a peptide incorrectly is no joke. I would MUCH rather use Epitalon in nasal spray form, in which case, getting the N-Acetyl version makes more sense given its higher bioavailability (which would help compensate for the slightly decreased efficacy of the nasal route).

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MemberMember
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(@abi72)
MemberMember
47
(@walden-rev)

Posted : 11/02/2016 2:29 am

On 11/2/2016 at 9:55 AM, ACCUiTy_drANE said:

I originally joined Acne.org to bring up this compound. I posted about it on AllThingsMale as well. [Edited link out]

TL;DR: Accutane's metabolite, All-trans Retinoic Acid (ATRA), appears capable of downregulating the telomerase enzyme. Epitalon can activate that exact enzyme. Telomerase is found in ADULT stem cells, which are relevant to repair functions throughout the ENTIRE body. This may explain the diversity of Accutane's side effects.

The problem is that Epitalon is sold in its "raw" form due its instability, so it is NOT shipped in a ready-to-insufflate or ready-to-inject form. If somebody made a video showing how to reconstitute Epitalon (specifically) into a nasal spray or injectable solution, I may embark on the Epitalon journey. I would also get my telomeres tested before and after using this compound.

I have a COMPLETE mental block whenever someone tries to explain to me (with words) how to reconstitute compounds and get the dosing correct based on the reconstitution. I would need a video that shows it step-by-step, because dosing a peptide incorrectly is no joke. I would MUCH rather use Epitalon in nasal spray form, in which case, getting the N-Acetyl version makes more sense given its higher bioavailability (which would help compensate for the slightly decreased efficacy of the nasal route).

[Edited link out]

so this version is not ready?
its 129 dollar

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MemberMember
1804
(@truejustice)

Posted : 11/02/2016 3:35 am

So no one is willing to give Iodine a shot discussed only one page ago??

We've skipped over that on to Epitalon and shit yeah? prob manufactured in Russia or something.....great.

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MemberMember
50
(@ehohel)

Posted : 11/02/2016 7:01 am

On 11/2/2016 at 9:55 AM, ACCUiTy_drANE said:

I originally joined Acne.org to bring up this compound. I posted about it on AllThingsMale as well. [Edited link out]

TL;DR: Accutane's metabolite, All-trans Retinoic Acid (ATRA), appears capable of downregulating the telomerase enzyme. Epitalon can activate that exact enzyme. Telomerase is found in ADULT stem cells, which are relevant to repair functions throughout the ENTIRE body. This may explain the diversity of Accutane's side effects.

The problem is that Epitalon is sold in its "raw" form due its instability, so it is NOT shipped in a ready-to-insufflate or ready-to-inject form. If somebody made a video showing how to reconstitute Epitalon (specifically) into a nasal spray or injectable solution, I may embark on the Epitalon journey.  I  would also get my telomeres tested before and after using this compound.

I have a COMPLETE mental block whenever someone tries to explain to me (with words) how to reconstitute compounds and get the dosing correct based on the reconstitution.  I would need a video that shows it step-by-step, because dosing a peptide incorrectly is no joke. I would MUCH rather use Epitalon in nasal spray form, in which case, getting the N-Acetyl version makes more sense given its higher bioavailability (which would help compensate for the slightly decreased efficacy of the nasal route).

I'm aware of how to reconstitute, and intend on going the injection route. And I'll probably  be trying the amidate version to better cross BBB.

edit: you want me to make a video of reconstitute + inject?

On 11/2/2016 at 4:35 PM, TrueJustice said:

So no one is willing to give Iodine a shot discussed only one page ago??

We've skipped over that on to Epitalon and shit yeah? prob manufactured in Russia or something.....great.

I've been following iodine protocol for 2 weeks almost, haven't noticed anything crazy, but will continue to take it. I've reached he point where I'll try anything that looks promising, I'm willing to rat lab this for you guys. :)

On 11/2/2016 at 3:29 PM, Walden Rev said:

[Edited link out]

so this version is not ready?
its 129 dollar

You need to reconstitute it, which is basically adding back water very carefully, once reconstituted, the peptide is very delicate.

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MemberMember
42
(@kynarr)

Posted : 11/02/2016 12:00 pm

On 11/2/2016 at 4:35 PM, TrueJustice said:

So no one is willing to give Iodine a shot discussed only one page ago??

We've skipped over that on to Epitalon and shit yeah? prob manufactured in Russia or something.....great.

I've been taking Iodine for about 2 weeks. I have more energy, feel less bloated, and feel sharper, as if my IQ somehow jumped up a couple points. It's a part of me I hadn't seen in many years. This may be completely unrelated to Accutane. As far as I understand it right now, we're dealing with too much fluoride, chloride and bromide in our world, which are all antagonist to Iodine. Interestingly, a lot of mainstream (and even paleo) sources are mostly against supplementing unless there is a proved deficiency. If you look deeper, you'll see talks about decalcifying different glands in the body, and people attempting mega doses of Iodine to try to get back to a normal state. It's definitely worth looking into.

I've only started taking Iodine due to claims that it helps heighten Testosterone levels. There's protocols about rubbing it directly on your testicles, something I've yet to try. I definitely suggest your get your hormone panel if you haven't already. Note that doctors seem to completely disregard low T for males. Read up about it. If you're anywhere below 500 total T, and you're not over 70 years old, something is likely wrong, and I have the feeling the main cause is Accutane.

Besides Iodine however, if there is one compound I believe everyone should try here, it's Calcium D Glucarate. I'm at over 90g in the past 2 months and the changes have been dramatic for me. I feel like crying typing this, as I believe I'm on my way to being cured.

Lastly, I just ordered a compound named Glucuronolactone. It seems to be a derivative of Calcium D Glucarate. There's just about no data on it you can find, except that there's some in energy drinks. Seems to deal more with the skin and connective tissues than CdG. It's also very cheap. As with CdG, it's supposed to help detoxify, and I'm curious if it would somehow act favorably in regards to Accutane.

Some Iodine sources:
http://www.curezone.org/faq/q.asp?a=13,281,2962&q=572
http://immortalhair.forumandco.com/t5892-dramatic-increase-in-dreams-since-iodine-supplementation
[Edited link out]
[Edited link out]

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MemberMember
157
(@tanedout)

Posted : 11/02/2016 4:04 pm

3 hours ago, Kynarr said:
Besides Iodine however, if there is one compound I believe everyone should try here, it's Calcium D Glucarate. I'm at over 90g in the past 2 months and the changes have been dramatic for me. I feel like crying typing this, as I believe I'm on my way to being cured.

Well Calcium D Glucarate is an aromatase inhibitor so it'll be lowering your estradiol levels (like Arimidex would, which I posted about on the previous page).

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6.I3C (Indole-3-Carbinol) + Calcium-D-Glucarate. One of our members, who had his estradiol slammed down too low by Arimidex, used these two supplements to successfully manage his estradiol. He said these brought him into the lower 20's and was very stable, i.e. he did not have any significant swings in estradiol.His dosage was: "Source Naturals 500mg. Morning and Evening, and Indole-3-Carbinol 200mg. with lunch.." [4] Again, you'll have to do your own research and find out if you think that these supplements are more safe than low dose Arimidex (anastrazole). Long term effects are poorly understood in both.

http://www.peaktestosterone.com/Natural_Estrogen_Blockers.aspx

I've taken this a couple of times, but only for a month or so. Recently took a higher dose (1.5g per day - 6 x Source Naturals capsules). What brand have you been using?

It's interesting that that was mentioned in that '8 tips for recovering from accutnae sides' video on youtube too.

Got nothing from iodine, and that's been discussed many times on this thread, however if you feel it may be helping I'd stick with it.

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MemberMember
42
(@kynarr)

Posted : 11/02/2016 7:37 pm

On 11/3/2016 at 5:04 AM, tanedout said:

Well Calcium D Glucarate is an aromatase inhibitor so it'll be lowering your estradiol levels (like Arimidex would, which I posted about on the previous page).

http://www.peaktestosterone.com/Natural_Estrogen_Blockers.aspx

I've taken this a couple of times, but only for a month or so. Recently took a higher dose (1.5g per day - 6 x Source Naturals capsules). What brand have you been using?

It's interesting that that was mentioned in that '8 tips for recovering from accutnae sides' video on youtube too.

Got nothing from iodine, and that's been discussed many times on this thread, however if you feel it may be helping I'd stick with it.

 

Not just that, it also regulates retinoids. It's great for anyone really, but especially for a post-Accutane user. I've dosed 3g at once for a couple days. Tried 6g once, but mostly now just take 1g at least once a day, up to three times. When I dose high amounts, I get acne. There's still these two times where I felt numb and peed something caustic, which I've yet to figure out, or find anything about really.

I buy CdG here:
[Edited link out]

Glucuronolactone here:
[Edited link out]

 

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MemberMember
158
(@accuity_drane)

Posted : 11/02/2016 8:03 pm

So LDNDoctor.com is totally legitimate. I just received a DOCTOR PRESCRIBED 90-day supply of 4.5 mg capsules of Naltrexone. The doctor call cost me $210 and the 90-day supply cost $49. I plan to cut the capsules in half, as 2.2 mg seems to be in the range many clinicians use for autism, inflammatory diseases, cancer, etc. I have high hopes this can help my IBS, brain fog, and relapsing skin cancer.

LDN should help bolster other treatments I try, such as dietary changes, supplement protocols, sleep schedule adjustments, workout routine, etc. I am feeling hopeful. (Just be sure no substances you use act on any opioid receptors.)

13 hours ago, ehohel said:
edit: you want me to make a video of reconstitute + inject?
If you don't mind. :) You may want to detail the exact materials used as well. From what I hear, it takes a lot more BAC water to dissolve the amidate form of Epitalon than the regular form. My biggest concern will be knowing how much I am injecting. The actual injection process doesn't frighten me; I just don't have the brain power to understand all the math jargon and what tools to buy. Anyone who believes in Nathan Carr's (see "Hoffmann-La Roche™s Cover-up of Accutane") finding about Accutane's mechanism of action should be HIGHLY interested in Epitalon. I, and probably many other lurkers, would be very thankful if you helped us out with this. Thank you.
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148
(@oli-girl)

Posted : 11/02/2016 10:56 pm

A little humor for the evening....I might of survived near death from Accutane, but I am not sure I will survive my cubbies tonight!!!!! Omg they are killing me uggh!!!!!!!!!!!!

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(@ehohel)

Posted : 11/03/2016 9:53 am

Hi, I also plan on getting a few blood tests before and after. I just want to know if these are the correct ones I'm looking at.

https://www.anylabtestnow.com/tests/testosterone-blood-test/

And should I do cortisol saliva test, or cortisol total test? (Total test is cheaper)
https://www.anylabtestnow.com/tests/saliva-cortisol-test/
https://www.anylabtestnow.com/tests/cortisol-test/

https://www.anylabtestnow.com/tests/estradiol-test/

are these all the correct ones? Thanks

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299
(@macleod)

Posted : 11/03/2016 5:56 pm

18 hours ago, oli girl said:

A little humor for the evening....I might of survived near death from Accutane, but I am not sure I will survive my cubbies tonight!!!!! Omg they are killing me uggh!!!!!!!!!!!!

crazy series and even crazier game 7. well deserved win though., congratz.

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MemberMember
223
(@gladiatoro)

Posted : 11/03/2016 10:39 pm

it is safe...the amount of hype on the internet about accutane...its like walking across the road and getting hit by a car...everyone walks across roads but how many get knocked down???
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Accutane Adverse Side Effects & Dangers

Abnormal menses

Abnormal wound healing (delayed healing or exuberant granulation tissue with crusting

Acne fulminans

Abdominal pain

Aggression

Agranulocytosis

Allergic Reactions

Allergic vasculitis often with purpura (bruises & red patches)

Alopecia

Alternations in blood sugar levels

Anaphylactic reactions

Anemia

Arthralgia

Arthritis

Back pain (severe in some cases, especially in children)

Birth defects

Bleeding & inflammation of the gums

Bone abnormalities

Bone fracture

Bronchospasms

Bruising

Calcification of coronary, pulmonary & mesenteric arteries

Calcification of ligaments & tendons

Cardiovascular injuries

Cheilitis (dry lips)

Colitis

Color vision disorder

Conjunctivitis

Corneal Opacities

Decrease in red blood cells

Decrease in serum high-density lipoprotein (HDL) levels

Decreased night vision (sometimes permanent)

Decreased Skeletal - Bone mineral density

Decreased white cell count

Delayed healing of bone fractures

Depression

Dizziness

Drowsiness

Dry mouth

Dry nose

Dry skin

Edema

Elevated CPK levels

Elevated platelet counts

Elevated sedimentation

Elevation of cholesterol

Elevation of serum triglycerides

Elevations of liver enzymes

Elevations of serum cholesterol

Emotional instability

Epistaxis

Eruptive xanthomas

Esophageal irritation

Esophageal ulceration

Esophagitis

Exacerbation of acne (acne made worse)

Eyelid inflammation

Fatal hemorrhagic pancreatitis

Fatigue

Fibrosis and inflammation of the myocardium

Flushing

Fragility of skin

Gastrointestinal symptoms (nonspecific)

Glomerulonephritis

Hair abnormalities

Headache

Hearing impairments

Hearing loss

Heart palpitations

Hepatitis

Hepatotoxicity

Hirsutism

Hyperostosis

Hyperpigmentation

Hypertriglyceridemia

Hyperuricemia

Hypopigmentation

Ileitis

Increased alkaline phosphatase, SGOT, (AST), SGPT (ALT), GGTP OR LDH

Increased risk of sunburn

Infections (including disseminated herpes simplex)

Inflammatory Bowel Disease

Insomnia

Impotence

Keratitis

Lethargy

Limb injury with physical activity

Lipids

Lupus

Lymphadenopathy

Malaise

Microscopic or gross hematuria

Muscle strain with physical activity

Nail dystrophy

Nausea

Nervousness

Neutropenia

Nonspecific urogenital findings

Optic neuritis

Osteopenia

Osteoporosis

Ovarian cysts

Painful intercourse

Pancreatitis

Papilledema

Paresthesias

Paronychia

Peeling of palms and soles

Photoallergic - photosensitizing reactions

Photophobia

Premature epiphyseal closure

Proteinuria

Pruritus

Pseudotumor Cerebri (benign intracranial hypertension)

Psychiatric disorders

Psychosis

Pyogenic granuloma

Rash (including facial erythema, seborrhea & eczema)

Rectal bleeding

Regional ileitis

Respiratory infection

Rhabdomyolysis

Seizures

Severe diarrhea

Severe neutropenia

Skeletal hyperostosis

Skeletal hyperostosis

Stroke

Suicidal ideations

Suicide

Suicide attempts

Sweating

Syncope

Systemic hypersensitivity

Tachycardia

Tendonitis

Thrombocytopenia

Tinnitus (ringing in the ears)

Transient chest pain

Urticaria

Vascular thrombotic disease

Vasculitis

Violent behaviors

Vision impairment

Visual disturbances

Voice alteration

Vomiting

Weakness

Weight loss

White cells in urine

 

Ok lets re-examine your analogy. In the real world you can cross the road when you see little or no obstacles. However, imagine that each side effect of accutane is a car/suv/truck. Now don't forget, since your taking accutane you are forced to cross the road despite the number of cars going by. How likely do you think it is that you'll cross that road without getting hit by at least one of the 150 obstacles?

I don't care if you take accutane, you seem stupid and if you die, eh more air for me. It's trying to spread "it's all hype, it's safe!" crap around.

Oh and BTW about 1/4 of the side effects can be fatal and many are life long side effects.This a WARNING to would be VICTIMS of pHARMa

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91
(@josephbuchignani)

Posted : 11/04/2016 4:14 am

> I plan to cut the capsules in half, as 2.2 mg seems to be in the range many clinicians use for autism, inflammatory diseases, cancer, etc.

IMHO this is a bad plan. 4.5mg is the standard. You may need slightly more or significantly less, but you should determine that experimentally.

Don't cut the pills in half. It's stable in a water solution for a month. You have to dissolve it anyway. Just take more or less liquid according to desired dose. If you cut the pills it will be imprecise, introducing error into your dosages.

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MemberMember
50
(@ehohel)

Posted : 11/04/2016 5:15 pm

Damn it, got my epitalon today, but my telomeres test wont be here till Monday. :(

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42
(@kynarr)

Posted : 11/05/2016 12:20 pm

19 hours ago, ehohel said:

Damn it, got my epitalon today, but my telomeres test wont be here till Monday. :(

Take your time.. ;)

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(@cnb30)

Posted : 11/05/2016 6:08 pm

For everybody taking NSI-189, hat was your dosage, and how long did it take before you noticed a change?

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50
(@ehohel)

Posted : 11/05/2016 7:39 pm

1 hour ago, cnb30 said:

For everybody taking NSI-189, hat was your dosage, and how long did it take before you noticed a change?

30mg freebase sublingual x2 daily, took 12ish days to notice it, really started noticing it earlier this week (one month).

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158
(@accuity_drane)

Posted : 11/05/2016 8:00 pm

3 hours ago, cnb30 said:

For everybody taking NSI-189, hat was your dosage, and how long did it take before you noticed a change?

Having done a 5 month cycle of NSI-189 Phosphate, I found that 20 mg administered once per day orally was optimal for me. For the first nine weeks, I did 40 mg, but I began to have unprovoked episodes of anxiety. I also developed some odd pains. Lowering my dose to 20 mg once per day increased NSI-189's therapeutic effects and lowered the side effects. Toward the end of my 5 month cycle when I did try to increase back up to 30 mg, the intermittent throbbing pains (hands, legs, arms) came back, so I took a break. If. If I recall correctly, it took a few weeks to notice its effects at first. Again, greater emotional depth was the most noticeable effect.

The relationship between NSI-189 and its therapeutic effects are on a bell curve. More is not necessarily better, but self-experimentation may be needed to find the perfect dose. I generally stayed away from dosing under the tongue (sublingual), because it introduces an unknown. On one hand, sublingual dosing may make it so a lower dose is needed to achieve optimal effects. But on the other hand, because we don't know how sublingual dosing impacts absorption for this particular substance, it may make dosing more confusing.

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MemberMember
1804
(@truejustice)

Posted : 11/05/2016 8:00 pm

19 minutes ago, ehohel said:
1 hour ago, cnb30 said:

For everybody taking NSI-189, hat was your dosage, and how long did it take before you noticed a change?

30mg freebase sublingual x2 daily, took 12ish days to notice it, really started noticing it earlier this week (one month).

What did you notice??

Increased energy
more moisture in skin
less joint pain
thicker hair
better night vision

I could go on........

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