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Repairing the long-term damage from Accutane

 
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(@kynarr)

Posted : 10/22/2016 1:44 pm

On 10/22/2016 at 1:52 AM, sacha_n said:
On 10/19/2016 at 10:05 PM, Kynarr said:

've tried Iodine supplementation for the first time last night and had crazy vivid dreams, which prompted me to research a bit, and I found this. Funny. First link I click, solely regarding Iodine and Dreams, and the first reply speaks of Finasteride. I haven't gone through the 400+ pages here. How has Iodine affected you long term? I feel very different this morning.

Hi, what is your iodine supplement? Iodoral is so expensive. One or two weeks ago I have had a few nights with very vivid dreams, they were closer to nightmares but I think I was feeling better/different the day after. Maybe I was getting some more iodine from my food..

I got this one. Not very expensive as far as I can tell here. It's tough to explain right now, but I feel like it's clearing up something.

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(@truejustice)

Posted : 10/22/2016 6:28 pm

On 10/23/2016 at 12:44 AM, Kynarr said:

I got this one. Not very expensive as far as I can tell here. It's tough to explain right now, but I feel like it's clearing up something.

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What led you to think iodine will help?? Are you deficient?

Why not Vid D liquid? I'm just trying to find out why iodine given thyroid function tests for most of us come back normal!!?

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(@abi72)

Posted : 10/22/2016 6:44 pm

On 10/16/2016 at 3:52 AM, TrueJustice said:
Info on there is 5 or more years old. Anyone know what happened to that guy Max who had all that info?

Just another one of those types who comes out all guns blazing with info and then disappears off the radar......bit like the guy who started this thread!!

Safe to say all our endocrine systems are fucked, problem is tests do fuck all, only solution is to meditate, try and get adequate sleep and rest. I'll try and sell my story to Dr to get some LDN - don't know what my chances are though of obtaining it??

Just another day in paradise.....

Indigo is still around. Still makes the odd youtube. Still suffering but wants to move on from accutane.
He is working , has a girlfriend and very big into animal welfare.
Learning to to the best in the circumstances.

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(@abi72)

Posted : 10/23/2016 2:40 am

Picked this up from one of kynarr's posts

http://lpi.oregonstate.edu/mic/vitamins/vitamin-A#nutrient-interactions

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(@gladiatoro)

Posted : 10/23/2016 10:35 am

23 hours ago, tanedout said:
The dosage is almost certainly irrelevant - some people have got persistent sides from taking a single pill - the same as with finasteride, saw palmto etc. I only took 10mg/day for 30 days but still have persistent sides 6+ years later.

If you only stopped one month ago just make sure you're eating a really clean diet, no alcohol etc and give your body its best shot at recovering.

I wouldn't say that , if you go on tan for one full year , you will have way more serious side effects vs a month for the simple fact that it's less poisoning. Honest derms will tell you that it is a controlled poisoning.

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(@abi72)

Posted : 10/23/2016 7:25 pm

On 10/23/2016 at 0:28 AM, TrueJustice said:
What led you to think iodine will help?? Are you deficient?

Why not Vid D liquid? I'm just trying to find out why iodine given thyroid function tests for most of us come back normal!!?

http://www.telegraph.co.uk/news/health/alternative-medicine/10985192/Could-a-renegade-doctor-save-your-life.html

http://www.telegraph.co.uk/news/health/alternative-medicine/10985192/Could-a-renegade-doctor-save-your-life.html

On 10/19/2016 at 10:10 AM, hatetane said:

SSRI's hitting the headlines in the UK - get on board and help highlight side effects of accutane in anyway you can!!!!

http://www.bbc.co.uk/news/health-37682355

This was on TV!

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(@truejustice)

Posted : 10/23/2016 8:15 pm

On 23/10/2016 at 10:44 AM, hatetane said:
Indigo is still around. Still makes the odd youtube. Still suffering but wants to move on from accutane.
He is working , has a girlfriend and very big into animal welfare.
Learning to to the best in the circumstances.

Thx for feedback. We all want to move on from accutane - nothing would ever please me more in this lifetime. Can't just ignore stuff and pretend it'll go away though!!

I wish him the best, sounds like the forum just became too much for him....

50 minutes ago, hatetane said:

Excellent info!!!

One thing that's never worked in our favour with us is that fucking blood tests rarely conclude anything - that's been such a massive setback for us as a group I've gotta say!!

Reading reports like this gives me hope - I feel like printing it off and showing it to my GP. Not to point the finger at her or anything as she's a great doctor but more to just say that all these inconclusive blood tests don't mean shit.

Just a question, how would LDN compare with iodine - many of us are seeking out LDN but would we yield better results from taking iodine???

I guess it would depend on what you're trying to treat, for me it is energy and mental clarity - exactly what that article sheds light on!!!

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(@helpmeoutbuddies11)

Posted : 10/23/2016 8:41 pm

On 10/22/2016 at 9:50 PM, oli girl said:

Helpmeoutbuddies11- You can read through and check out this thread that a couple years ago some Accutane suffers made in the Rosacea forum. Do youhave flushing and blushing consistently or just at random times?
http://www.acne.org/messageboard/topic/193804-post-accutaneminocycline-facial-flushing/

My face has changed. It's always pretty pink except for when I wake up in the morning when it is dang pale. My cheeks are always always red and I seem to blush pretty randomly, but very often. Sometimes I don't even know it's happened until I look in a mirror and am a tomato.

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(@truejustice)

Posted : 10/24/2016 4:02 am

Interesting that when you look into Iodine and the Lymphatic system it mentions that much of the body's Lymph is found in the gut and it's critical that the Villi are healthy for proper Lymph flow, goes on to say that Iodine deficiency can cause Lymphatic congestion!!

I always thought Lymph nodes were found only in ones neck region.

So again we find ourselves addressing gut issues to get on top of our problems - even the depression from lack of serotonin stems from a damaged gut. I don't know if any gut test that would determine if the Villi is damaged or not??

I do know that getting a poo transplant is something my Gastro Dr is looking to do with me in a few months....should be interesting, I'd of never entertained this idea years ago but these days I'll do whatever it takes!!!

Anyone who's on Iodine supplements pls keep reporting if you're having success with it :) 

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(@unevenpetal)

Posted : 10/24/2016 7:12 am

I believe that the only thing everyone seems to be recommending so far isCalcium DGlucarate.Can anyone confirm that taking this has helped erectile dysfunction and decreased sex drive??
And are there any other supplements or treatments, etc that have worked on similar symptoms?

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(@kynarr)

Posted : 10/24/2016 9:12 am

On 22/10/2016 at 7:28 PM, TrueJustice said:
What led you to think iodine will help?? Are you deficient?

Why not Vid D liquid? I'm just trying to find out why iodine given thyroid function tests for most of us come back normal!!?

It was just a supplement on my radar. On my latest post I referred to a thread I created in another forum, which I recommend you read at it's quite extensive. One member there suggested Iodine for low T. I expected nothing of it as most sources on the net advise against supplementing, but wow has it affected me just this past week. I'll report more as I learn about it over the next couples days. I've no idea if this has anything to do with Accutane. Might just have been something my body needed.

To answer UnevenPetal, CdG has helped me greatly. It hasn't completely fixed me and I still have dry face skin, but it's worth taking if only to detoxify from all the stuff around us and to clear excess Estrogen. ASSUMING we're dealing with vit A toxicity, CdG is supposed to regulate retinoids. It's an expensive supplement, but I would say absolutely yes, you should try it. Has it helped my libido? Absolutely not. If you want to fix you sexual health, drop all porn, stop masturbating, practice semen retention. You'll see.

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(@gladiatoro)
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(@unevenpetal)

Posted : 10/24/2016 1:39 pm

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4 hours ago, Kynarr said:
To answer UnevenPetal, CdG has helped me greatly. It hasn't completely fixed me and I still have dry face skin, but it's worth taking if only to detoxify from all the stuff around us and to clear excess Estrogen. ASSUMING we're dealing with vit A toxicity, CdG is supposed to regulate retinoids. It's an expensive supplement, but I would say absolutely yes, you should try it. Has it helped my libido? Absolutely not. If you want to fix you sexual health, drop all porn, stop masturbating, practice semen retention. You'll see.

I haven't watched porn much at all since it happened and never feel the need to masturbate. I have a girlfriend and am able to have sex quite often but it's not the same and it's harder to keep an erection. Unless someone actually touches my genitals I don't really get turned on. I am tempted to Testosterone Replacement Therapy to see if it brings back my sex drive but it is a big commitment. Might try CdG first to see if removing some estrogen will bring it back.

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(@weltschmerz47)

Posted : 10/24/2016 8:16 pm

Does anyone with sexual effects also haveAdenosine monophosphate deaminase deficiency type 1 /myoadenylate deaminase deficiency ? I don't post much in here anymore but read often.. I think I may have found something.

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(@monsterdiesel)

Posted : 10/24/2016 10:34 pm

On 10/19/2016 at 2:34 AM, ACCUiTy_drANE said:

That being said, there are lower risk substances that cause neurogensis, some of which I take regularly. Examples: Tianeptine (on it), Lion's Mane (on it), Curcumin, Semax

can you comment on Lions mane. Any improvements in memory and word recall? I just ordered some.

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(@macleod)

Posted : 10/25/2016 1:22 am

4 hours ago, Weltschmerz47 said:

Does anyone with sexual effects also haveAdenosine monophosphate deaminase deficiency type 1 /myoadenylate deaminase deficiency ? I don't post much in here anymore but read often.. I think I may have found something.

This was an interesting read. I don't have complete sexual dysfunction but I did lose probably around 20% of my libido (only took tane for a month), however this deficiency mentioned lactic acid. And I find that interesting because I basically have no lactic acid sensation during exercise anymore and the muscles work to failure, not fatigue. I can run miles and miles and don't know when enough is enough, but only after years of trial and error, through stress buildup sensations in the bones and tendons, and common sense judgement. I can also lift for super sets (5-6) usually and several reps (15-20) and it is near impossible to reach a "pump" (blood flow peak) in the muscle. Needless to say delayed onset muscle soreness is completely different as well. Sometimes 48-96 hours later. Not the norm.

My question is, since I clearly had none of this pre-accutane, was this an underlying issue or did the drug cause this deficiency?

Does anyone else out there have similar symptoms?

Also, this is just one of what? 100 symptoms. One of the least of my worries, but if it helps in tackling the others as well, I'll try and focus on it.

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(@josephbuchignani)

Posted : 10/25/2016 7:54 am

I got around to resuming my LDN regimen and Googled it a bit to refresh my memory:

1. It lasts 30 days in the fridge. I'd thought the liquid shelf life was shorter. So I strongly recommend that only one person per country purchase and then share a few pills with all those who wish to trial it.

2. The slow dosage increase recommended in one report I saw was .5mg / week. So a 1-3 month ramp up.

3. Most obvious side effect for me of overly aggressive ramp-up is still sleep shortened by an hour or two, less satisfying sleep, and more vivid dreams. In a 4.5mg / 90 ml solution, I started at 1 ml, jumped to 3, then to 7, then to 5, might drop to 3. Just feeling it out. Other factors affect my sleep too. (Adding garlic certainly contributed to the sleep issue, and maybe solely accounts for it.) A full daily dose is 90ml or 4.5 mg.

In general I tend to modify multiple variables at once and become more conservative or more aggressive in waves based on daily biofeedback. Since I had the aforementioned mild sleep impact I'll now eliminate variance except LDN to dial in the correct dosage increase schedule. I'm still doing great but I pay close attention to sleep quality as a KPI.

My definition of "doing great" is e.g. being productive at software development without any particular biological strain.

http://www.ldnresearchtrust.org/sites/default/files/Doctors info pack - US - 2014.pdf

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(@kynarr)

Posted : 10/25/2016 10:01 am

Anybody looking at LDN should first look at Iodine. They go hand in hand it seems and forums regarding LDN recommend Iodine protocols. The difference is Iodine is cheap and convenient to try. I don't buyinto the idea that we must pay hundreds of dollars for a single supplement which *may* help us. Fuck that. We should however use this interest to look more into Iodine.

I'm putting together the data right now, but I believe nobody here really looked at Iodine as a possible issue following Accutane. There seems to be many correlations to our symptoms. Not many scientific data I can find but one that follows. I'll just say it now, no supplement has ever impacted me as much as Iodine, and it's only been a week, and I'm only doing up to 1mg a day. It's night and day. I'm a different person.

[Edited link out]

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(@mike-san)

Posted : 10/25/2016 10:41 am

Interesting... I never tested for iodine. My t3, t4, tsh are in the normal range though. Would taking iodised salt every day be advisible just in case, and if so, how much?

Also, does anyone have any issues eating eggs? I noticed they contain a fair bit of retinol. Taking a retinoil suppmade me very ill, however, being from food sources , it could be different? Id hate to give up or limit eggs.

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(@cnb30)

Posted : 10/25/2016 11:11 am

Just ordered nsi-189. I'm feeling hopeful that I will see at least some return to my former self. Also, does anybody here know more about hippocampal repair?

Also, does anybody here still feel the urge to masturbate alot, yet still have a very low libido, and erectile problems?

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(@ehohel)

Posted : 10/25/2016 3:17 pm

On 10/25/2016 at 11:01 PM, Kynarr said:

Anybody looking at LDN should first look at Iodine. They go hand in hand it seems and forums regarding LDN recommend Iodine protocols. The difference is Iodine is cheap and convenient to try. I don't buyinto the idea that we must pay hundreds of dollars for a single supplement which *may* help us. Fuck that. We should however use this interest to look more into Iodine.

I'm putting together the data right now, but I believe nobody here really looked at Iodine as a possible issue following Accutane. There seems to be many correlations to our symptoms. Not many scientific data I can find but one that follows. I'll just say it now, no supplement has ever impacted me as much as Iodine, and it's only been a week, and I'm only doing up to 1mg a day. It's night and day. I'm a different person.

[Edited link out]

I've been following iodine protocols for half a week now, and starting LDN in about a week once it comes in. Will report back if any significant differences.

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(@nicholas-ross)

Posted : 10/25/2016 4:31 pm

Anybody have extreme lack of concentration. Like I can't watch a tv show without turning it off within minutes. The only time I watch is when i'm with my girlfriend and i have to keep asking her questions about whats happening because I get lost easily. Same with reading. I used to love reading books and It was possible to read a book in one day when I'd take an adderall. Now, I couldn't care less about reading or intellectual activities. I feel like i'm not smart anymore.

I have a history of ADHD, Depression, and Bi-polar. After taking accutane 9 years ago, I've changed so much. And the side effects are still with me after nine years! Headaches, eye pain, etc. I can't believe I am still living on this earth after so long.

I'm just hoping for a cure. Like brain surgery or something...Are there any medications out there worth staying on long term?

I can't continue staying in my room all my life hiding from people. I need a job, and to stick with it. (I always end up quitting a job due to side effects from accutane) The last job I had I quit because of my back pain and I can't concentrate for shit and plus the anxiety/depression.Fuuuuuckkk.

I don't think anyone can help me. I just came on here to vent.. Smoking weed helps. Exercising daily helps a lot. Atleast 20 minutes of working out. Eating a really good diet. For me no dairy. Processed foods is a no. Lot's of water is good. Like a whole jug of water. I think liver flushes seem to help. I've done 2 so far.

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(@monsterdiesel)

Posted : 10/25/2016 5:54 pm

All my thyroid tests are also normal. But I have hypo sx like low body temp. My hands and feet are usually ice cold. I've tried iodine in different dosages. Can't decide if it helps or not..

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(@helpmeoutbuddies11)

Posted : 10/25/2016 8:42 pm

Does anyone know if thyroid problems could be related to accutane induced rosacea/flushing/blushing? Could iodide help that side effect at all?

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(@accuity_drane)

Posted : 10/25/2016 8:58 pm

On 10/24/2016 at 11:34 PM, MonsterDiesel said:
can you comment on Lions mane. Any improvements in memory and word recall?  I just ordered some.  
I have only been on it for 1.5 months. My current regimen includes Lion's Mane, Tianeptine, Agmatine, Fish Oil, and Vitamin D. It's hard to say what is helping. But Lion's Mane is something you must be on for a very long time to see results.  My stack as a whole has helped my irritability and I have started to have some days where I feel grounded. In terms of memory, I believe it has improved, but comprehension has traditionally been a bigger issue than memory for me.

I started this medicinal mushroom because it may help with myelin sheath repair. And considering Accutane is a 5-Alpha Reductase Inhibitor (and therefore causes downregulation of neurosteroids)  as well as a chemotherapy drug, that's two ways myelin sheath potentially could have been damaged.
 

Word of caution: Please be sure you bought it from a vendor who does purity testing. It is VERY common for vendors to take shortcuts with medicinal mushrooms. They grow mycelium (the "root" of the mushroom) in rice and mix it together prior to the ACTUAL fruiting body (i.e., mushroom) fully developing. A truly reliable vendor will be able to tell you how much active ²-Glucans the extract contains. I would bet much of the Lion's Mane on the market is bunk. :( Hopefully I'm wrong though.
 

7 hours ago, Damaged_ said:

Anybody have extreme lack of concentration. Like I can't watch a tv show without turning it off within minutes. The only time I watch is when i'm with my girlfriend and i have to keep asking her questions about whats happening because I get lost easily.

Yep, comprehension has always been a big problem of mine. I remember when I first got off Accutane, I tried to watch a popular movie at a theater and did not catch a single aspect of the plot. It was utterly nonsensical to me. My friend tried to talk about the movie with me but I had NOTHING to say. I honestly think these cognitive issues are the underlying reason for my anhedonia/depression. If I cannot focus or feel immersed in any form of entertainment, it's hard to look forward to a day off. Or the release of a new movie/video game/book.  I think this problem directly affects any form of work I do as well. My brain never aligns, or calibrates, with the task I am doing. So I'm left feeling foggy headed all the time. It's the best way I can describe it, man.
 

7 hours ago, Damaged_ said:

I'm just hoping for a cure. Like brain surgery or something...Are there any medications out there worth staying on long term?

 
I'm not sure how you experience your depression. For me, I feel numbed out. Many people associate this feeling with depression, but it's also a common negative symptom of other diseases such as schizophrenia. It's worth noting some users report Sarcosine (amino acid in muscles) and Agmatine (neurotransmitter derived from amino acid L-arginine) both offer some relief for that. My personal favorite anti-depressant is an outdated drug called Tianeptine. It fights depression a million different ways: neurogenesis of hippocampus (part of brain associated with learning and memory), suppression of amygdala (part of brain associated with fear), boosts mitochondria in brain, diminishes the impact of stress on brain via modulation of NMDA receptors, and increases neuroplasticity. No sexual sides.
 

MAOI depression drugs are also making a comeback, as research shows they are effective for treating depression and do not require AS MUCH dietary restrictions as previously thought. They seem less prone to tolerance issues and do not give users a "numbing" effect like SSRIs do. Still, I'm avoiding going to this territory until other options have failed. Best of luck! There are lots of promising antidepressants around the corner. :)

 
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