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Just seen this posted on the ATM forum, results from Havard Finasteride side effects study (in summary, it's pretty inconclusive)
[Edited link out]
Has anyone anyone use Lycopene and can comment on any benefits or side effects?
Like most of you here, I cannot eat foods high in vitamin a or beta carotene as they cause sides like headache and joint pain. However, foods high in Lycopene do not.
Lycopene is a nonprovitamin A carotene. I went thru some interesting studies i'll post later. Took me all day to post this..didnt take my methionine this morning and was in the gutters all day.
On 10/6/2016 at 3:45 AM, tanedout said:Just seen this posted on the ATM forum, results from Havard Finasteride side effects study (in summary, it's pretty inconclusive)
[Edited link out]
Just quickly looked at the conclusion of that article:
"We found no evidence of androgen deficiency, decreased peripheral androgen action, or persistent peripheral inhibition of SRD5A in men with persistent sexual symptoms after finasteride use. "
I don't really know much about the theories and studies etc so not sure what this means.
Are they saying that there is basically no explanation for pfs? That the androgen receptor theory has been disproved?
I tried to find some supplements to ease a dehydrated body. Most things that come up on a google search talk about electrolyte replacement which isn't what I'm after.
Digging a bit deeper it starts to go into joint care which is where Baxyl starts to come up. One particular website only gave it a 65% rating compared to another product called FlexoPlex which got a fantastic rating of 95%. It contains the Hyaluronic Acid that Baxyl has plus much more I believe - could be worth investigating for those who still have painful joints.
Not sure how good it would be for the skin & hydration?
12 hours ago, TrueJustice said:I tried to find some supplements to ease a dehydrated body. Most things that come up on a google search talk about electrolyte replacement which isn't what I'm after.
Digging a bit deeper it starts to go into joint care which is where Baxyl starts to come up. One particular website only gave it a 65% rating compared to another product called FlexoPlex which got a fantastic rating of 95%. It contains the Hyaluronic Acid that Baxyl has plus much more I believe - could be worth investigating for those who still have painful joints.
Not sure how good it would be for the skin & hydration?
Is flexopro in liquid form?
Hi, checking in after some time.
Doing pretty well. In a great shape physically, cognitively quite strong. Energy levels could be better but it's ok, no coffee or other stimulants at all.
However nothing changes when it comes to libido. Still ZERO.
I'm working on improving my dopamine receptors thanks to a one very knowledgeable man who is helping me taking now: urudine, cdp-choline, sulubtiamine. Just started month 2, first month I took also phenylpiracetam but due to no signs of anything now trying oxiracetame.
This treatment is meant for 3months. You'll be first to know how it went or what are my next steps.
However - just received my MTHFR gene test...
Turns out that
1) C677T is not mutated
2) a1298c heterozygous mutation positive 
Could you tell me if this has been discussed and if there are any usefl materials to study?
52 minutes ago, pabpab said:Hi, checking in after some time.
Doing pretty well. In a great shape physically, cognitively quite strong. Energy levels could be better but it's ok, no coffee or other stimulants at all.
However nothing changes when it comes to libido. Still ZERO.I'm working on improving my dopamine receptors thanks to a one very knowledgeable man who is helping me taking now: urudine, cdp-choline, sulubtiamine. Just started month 2, first month I took also phenylpiracetam but due to no signs of anything now trying oxiracetame.
This treatment is meant for 3months. You'll be first to know how it went or what are my next steps.However - just received my MTHFR gene test...
Turns out that
1) C677T is not mutated
2) a1298c heterozygous mutation positiveCould you tell me if this has been discussed and if there are any usefl materials to study?
I'm also hetrozygogous for a1298c (along with all the MTHFR genes). THere's quite a few places you can run the data through for free to get some more info, I think Genetic Gene is best.
MTHFR A1298C
MTHFR A1298C is involved in converting 5-methylfolate (5MTHF) to tetrahydrofolate (THF). Unlike MTHFR C677T, the A1298C mutation does not lead to elevated homocysteine levels. This reaction helps generate BH4. BH4 is important for the detoxification of ammonia. The gene is compromised about 70% in MTHFR A1298C (+/+) individuals, and about 30% in people with a heterozygous (+/-) mutation.
BH4 acts as a rate limiting factor for the production of neurotransmitters and catecholamines including serotonin, melatonin, dopamine, norepinephrine, and epinephrine. A MTHFR A1298C + status may cause a decrease in any of these neurotransmitters or catecholamines. BH4 is also a cofactor in the production of nitric oxide. A dysfunctional BH4 enzyme may lead to mental/emotional and/or physical symptoms. Mercury, lead, and aluminum may act as a drain on BH4.
43 minutes ago, tanedout said:I'm also hetrozygogous for a1298c (along with all the MTHFR genes). THere's quite a few places you can run the data through for free to get some more info, I think Genetic Gene is best.
This is getting quite relevant. It's obvious that my neurotrasmitters are messed up. Namely dopamine. Confirmed by tests and every day life observations...
Problems with A1298Cgene mutations
As you can see above the problems experienced by those with the A1298C gene mutation are more likely to beassociated with neurotransmitters, these are the chemicals that control your brain, how you feel, your tolerance to stress, your mood, your ability to concentrate, your ability to relax, your ability to feel happy, your sensitivity to pain, your ability to learn and remember and so on.
Often those with the A1298C gene cant make enough serotonin which causes depression and or anxiety. Neurotransmitters are extremely important and imbalances can dramatically affect a persons life, often those with neurotransmitter problems can experience any of the symptoms of MTHFR becausebrain chemicals control how you feel, which can result in many and varied symptoms. For example, if you have the A1298C gene mutation you will likely make less supportive neurotransmitters, this causes mental stress which goes on to cause physical stress, when this happens your body needs more resources to be able to cope, resources then become depleted, this can then lead to any mental and or physical health problem/s.
edit: can you link to this genetic gene thing?
14 minutes ago, pabpab said:
This is getting quite relevant. It's obvious that my neurotrasmitters are messed up. Namely dopamine. Confirmed by tests and every day life observations...
Problems with A1298Cgene mutations
As you can see above the problems experienced by those with the A1298C gene mutation are more likely to beassociated with neurotransmitters, these are the chemicals that control your brain, how you feel, your tolerance to stress, your mood, your ability to concentrate, your ability to relax, your ability to feel happy, your sensitivity to pain, your ability to learn and remember and so on.
Often those with the A1298C gene cant make enough serotonin which causes depression and or anxiety. Neurotransmitters are extremely important and imbalances can dramatically affect a persons life, often those with neurotransmitter problems can experience any of the symptoms of MTHFR becausebrain chemicals control how you feel, which can result in many and varied symptoms. For example, if you have the A1298C gene mutation you will likely make less supportive neurotransmitters, this causes mental stress which goes on to cause physical stress, when this happens your body needs more resources to be able to cope, resources then become depleted, this can then lead to any mental and or physical health problem/s.
edit: can you link to this genetic gene thing?
Some decent links on there too! I was supplementing with methylB12 for some time, along with some methylfolate, but it seemed cause my blood pressure to rise after 3-4 weeks of 2mg methyl B12 and the odd bit of folate, but felt pretty good up to that point (better mental clarity, increased confidence etc). I've not really followed any protocols to follow that specific mutation, the B12/folate is for the MTHFR mutation.
On 10/3/2016 at 0:36 AM, TrueJustice said:Thx for your reply.Sorry, what levels are you referring to that you measured?
your tip with methionine has helped. Vit B12 by itself wasn't doing much but when taken with TMG my depression lifts, slightly but noticeable!
Im still thinking of taking LDN. This combination of both depression and fatigue is crippling at times so anything that even helps slightly I'm interested in!!
Ill also look into the other things you've mentioned. When you say "wasting", what exactly are you referring to? Muscle, brain, liver, whole body??
I meant my lithium levels. I was puzzled by why it was so low seeing my diet was rich in fruit and veggies.
Glad these things helped. I get the impression that there's a monotherapy mentality in this forum. That is, looking for that one thing that will cure you. It's not the way to go. There's ample research showing all the different pathways accutane affects and that means taking a little of this and a little of that until you're balanced like biotin, b12, folate, methionine, choline, etc..
When I said wasting I meant in my body. I have virtually no muscle and all my efforts at the gym don't pay off. I simply can't retain any musculature. Before Accutane, I could get big easily. MIght be related to the low testosterone obviously but it's not low enough that doctors agree to treat it.
I'm also the guy that got the liver biopsy that showed Hydropic change (a sign of liver damage but no fibrosis). Mind you, that was 6--7 years after I took accutane and I had already taken liver supportive supplements. At the time, my doctor was suspecting iron of copper overload since he saw many little things wrong he couldn't explain. All came back normal. Cerulopasmin was normal too.
What do you think LDN will accomplish?
1 hour ago, MonsterDiesel said:I meant my lithium levels. I was puzzled by why it was so low seeing my diet was rich in fruit and veggies.Glad these things helped. I get the impression that there's a monotherapy mentality in this forum. That is, looking for that one thing that will cure you. It's not the way to go. There's ample research showing all the different pathways accutane affects and that means taking a little of this and a little of that until you're balanced like biotin, b12, folate, methionine, choline, etc..
When I said wasting I meant in my body. I have virtually no muscle and all my efforts at the gym don't pay off. I simply can't retain any musculature. Before Accutane, I could get big easily. MIght be related to the low testosterone obviously but it's not low enough that doctors agree to treat it.
I'm also the guy that got the liver biopsy that showed Hydropic change (a sign of liver damage but no fibrosis). Mind you, that was 6--7 years after I took accutane and I had already taken liver supportive supplements. At the time, my doctor was suspecting iron of copper overload since he saw many little things wrong he couldn't explain. All came back normal. Cerulopasmin was normal too.
What do you think LDN will accomplish?
LDN - prob nothing, just another placebo that works for 3 days. I did hear it helps those with chronic fatigue.....that's me!!!
I know what you mean with monotherapy with regards to supplements BUT I'll say it again - those who maintain they're cured did so through Liver Flushing!!
I've still got know idea - I just continue to throw everything at my problems till something sticks, including liver flushes.
I think Lycopene might be a good antioxidant and hepatoprotective agent for those suffering from Accutane use. Click on the blue links for the relevant studies.
Lycopene is best absorbed as 13-cis Lycopene and being a fat soluble nonprovitamin A caretonoid, it is stored in the liver into the Stellate (ito) cells, where it can serve a direct antioxidant function where we need it most. I like that about lycopene. It also doesn't seem to cause sides like joint pain when I consume tomato products or watermelon since it is not converted to vitamin A like beta-carotene.
No idea if this can displace excess vitamin A or isotreinoin if it is indeed stored in the liver.
For comparison, more than two eggs or two apples at once and I get sides. I also like the idea of a carotene restoring any damage done by vitamin A. Like poetic justice. I haven't tried Lycopene supplements but I'm sipping on some tomato juice as I write this.
Here are some features:
- Found in Gac fruit, tomatoes, watermelon. Gac fruit oil from vietnam is very high in lycopene but also has beta carotene..
- Strong hepatoprotective antioxidant that helps de-fat the liver and restore antioxidant molecules.
- NRF2 and SIRT-1 activator.
- Lycopene improved liver function and protected the liver from damage due to gall bladder obstruction.
- Lycopene stabilizes liver function during d-galactosamine/lipopolysaccharide induced hepatitis in rats.
- lycopene promotes parenchymal cell regeneration in liver, thus protecting membrane fragility thereby decreasing enzyme leakage and restoring the normal liver cell integrity.
Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats
- Inhibits liver fibrosis.
- Can activate Retinoic Acid receptors and Retinoic X receptors - unsure of the implications.
Anyone have any experience with Lycopene?
Has it been mentioned before that 13-cis retinoic acid is naturally present in the body and some plants in minute quantities?
QuoteOccurrence
The mean concentration of 13-cis-retinoic acid in the plasma of fasting individuals is 5.4 nmol/L (Eckhoff & Nau, 1990; Blaner & Olson, 1994). The 145 ARC Handbooks of Cancer Prevention mean concentration of a major metabolite, 13-cis- 4-oxoretinoic acid, is somewhat higher, i.e. 11.7 nmol/L (Eckhoff & Nau, 1990). Most other tissues of the body also contain 13-cis-retinoic acid, at concentrations 10 or more times higher than that of plasma (Napoli, 1994). The 13-cis-retinoic acid concentration is < 1% that of all-trans retinol in human plasma and <5% that of total vitamin A in the tissues of healthy animals and humans. Since 13-cis-retinoic acid is present, if at all, in only traces in plants, it is a very minor constituent of the diet, and consequently contributes very little to the intake of dietary vitamin A. 13-cis-Retinoic acid, unlike vitamin A and carotenoids, is not available as a dietary supplement.
[Edited link out]
QuoteBecause 13-cis-retinoic acid is rapidly metabolized by the body and is not stored in the liver or other organs, it does not accumulate over time (Blaner & Olson, 1994)
This doesnt mention if the other metabolites are stored in the liver. That PDF has a goldmine of information about Accutane.
Quote13-cis-Retinoic acid itself does not bind to retinoid receptors, but it can be considered to be pro-drug of all-trans-retinoic acid because it can be isomerized to the trans conformation in animal systems. Therefore, 13-cis-retinoic acid probably exerts its effects by regulating gene expression after being converted to all-trans-retinoic acid, a direct ligand.
A prodrug is a medication that gets converted to its active form in the body. In this case, accutane toxicity is really cause by an overload of all-transretinoic acid. This opens up other research possibilities into the mechanisms of its long-terms effects.
I have some pretty ground breaking news that I want to share with you all!
So, lately my pancreatitis has been in a bad way. Been dealing with it for about 2 years off and on, so naturally it has progressed to 'chronic' and gotten steadily worse. I experimented with antioxidant supplements and digestive enzymes, and they of course help to some degree, however I tend to ween off of them because I want my body to function as it once had. I don't want to rely on them. Every time I seem to get things under control and try to get back to eating full regular meals of all kinds in an attempt to put on weight, I am met with a re-angered pancreas. I know when I am near an acute pancreatic episode because my stomach will grumble an entire day after introducing food, my lymph glands in my throat will start to swell, as if I'm getting a flu, and i must immediately cease all food, or I risk my fourth or fifth acute pancreatic attack in 2 years.
So, to the point. My pancreas was upset so I fasted for about 4 days. It's a good experience really. Everyone should try it at least once. You feel all of the inflamed/damaged parts of your body (most people its the joints and tendons tend to throb) as your body makes a last ditch effort to retrieve nutrients and in the process, it eats up toxins, and repairs itself on the cellular level. In fact, fasting is one of the ONLY ways one is able to proliferate the beta cells within the pancreas (ask any scientist). I usually do this and symptoms tend to resolve and I can reintroduce liquids to plants/fruits gradually, then back to full meals within a week, except this time my pancreas did not go for it, and everytime I ate and got a full nights sleep, I would wake up feeling like absolute dross, I mean worse than just the Accutane brain and lethargy and depression that we already have.. I'm talking drinking water, eating healthy salad and fruits, sleeping 8+ hours and waking up feeling hungover, and like shit, in the gutters. I briefly was at a point where I was going to seek medical help because fasting for the first time didn't work and I was worried it could be pancreatic cancer.
I only say this because not only was a lugging around an inflamed pancreas in my left quadrant all the time, but lately the lower right quadrant (liver) had been inflamed past couple months as well. Not necessarily at the same time, but at different times throughout the day, you know when you feel them too (dull radiating pain). I thought o.k., I probably have mild chronic pancreatitis and possibly some form of fatty liver hepatitis which is more likely than having a cancer that spread from one organ to the other (unlikely, but still possible) knowing how messed up our cells are after Accutane.
I then started to research all the candida stuff people had been posting here because some of you also mentioned things about fatty livers, etc.
Keep in mind, all the while I'm feeling like absolute strung out lethargic, especially after meals of any kind (healthy fruits and veggies), and with full nights of sleep. Waking up to 15-20%, it was not good, almost gave up and went to a doctor.
But the key here was that I was dealing with an inflamed pancreas, inflamed liver, inflamed tendons, you name it, I mean it felt like systemic inflammation. So, I started to research systemic inflammation.
https://en.wikipedia.org/wiki/Systemic_inflammation
I stumbled on things like Tolerogenic, and somehow these papers led me to a research journal talking about digestive diseases and how mortality risk was increased significantly from lack of vitamin A within these patients with their respective digestive issues which ceased after supplementation (which I will find for you all and insert here). I put two and two together (my night blindness) our systemic issues, similar but same side effect profiles...I went home and took 25,000 iu of beta carotene and I'll be damned but I haven't had not even a slight twinge out of my pancreas or liver, and its been almost a week. I'm back to eating and I'm just completely amazed. this is pretty earth shattering, because if you knew my pancreas like I know it, and a couple days of beta carotene have calmed it completely, is just incredible to me and it should be to you as well, if your dealing with IBS or digestive inflammation of sorts from Accutane.
I urge everyone to start from scratch, and focus on this vitamin A trail again. If our vitamin A readings are reading normal, then we need to look at what is wrong with the receptors. It could be that some of us are dealing with toxicity, some deficiency, but somethings askew.
^ add to your bookmark
8 hours ago, macleod said:I have some pretty ground breaking news that I want to share with you all!
So, lately my pancreatitis has been in a bad way. Been dealing with it for about 2 years off and on, so naturally it has progressed to 'chronic' and gotten steadily worse. I experimented with antioxidant supplements and digestive enzymes, and they of course help to some degree, however I tend to ween off of them because I want my body to function as it once had. I don't want to rely on them. Every time I seem to get things under control and try to get back to eating full regular meals of all kinds in an attempt to put on weight, I am met with a re-angered pancreas. I know when I am near an acute pancreatic episode because my stomach will grumble an entire day after introducing food, my lymph glands in my throat will start to swell, as if I'm getting a flu, and i must immediately cease all food, or I risk my fourth or fifth acute pancreatic attack in 2 years.
So, to the point. My pancreas was upset so I fasted for about 4 days. It's a good experience really. Everyone should try it at least once. You feel all of the inflamed/damaged parts of your body (most people its the joints and tendons tend to throb) as your body makes a last ditch effort to retrieve nutrients and in the process, it eats up toxins, and repairs itself on the cellular level. In fact, fasting is one of the ONLY ways one is able to proliferate the beta cells within the pancreas (ask any scientist). I usually do this and symptoms tend to resolve and I can reintroduce liquids to plants/fruits gradually, then back to full meals within a week, except this time my pancreas did not go for it, and everytime I ate and got a full nights sleep, I would wake up feeling like absolute dross, I mean worse than just the Accutane brain and lethargy and depression that we already have.. I'm talking drinking water, eating healthy salad and fruits, sleeping 8+ hours and waking up feeling hungover, and like shit, in the gutters. I briefly was at a point where I was going to seek medical help because fasting for the first time didn't work and I was worried it could be pancreatic cancer.
I only say this because not only was a lugging around an inflamed pancreas in my left quadrant all the time, but lately the lower right quadrant (liver) had been inflamed past couple months as well. Not necessarily at the same time, but at different times throughout the day, you know when you feel them too (dull radiating pain). I thought o.k., I probably have mild chronic pancreatitis and possibly some form of fatty liver hepatitis which is more likely than having a cancer that spread from one organ to the other (unlikely, but still possible) knowing how messed up our cells are after Accutane.
I then started to research all the candida stuff people had been posting here because some of you also mentioned things about fatty livers, etc.
Keep in mind, all the while I'm feeling like absolute strung out lethargic, especially after meals of any kind (healthy fruits and veggies), and with full nights of sleep. Waking up to 15-20%, it was not good, almost gave up and went to a doctor.
But the key here was that I was dealing with an inflamed pancreas, inflamed liver, inflamed tendons, you name it, I mean it felt like systemic inflammation. So, I started to research systemic inflammation.
https://en.wikipedia.org/wiki/Systemic_inflammation
I stumbled on things like Tolerogenic, and somehow these papers led me to a research journal talking about digestive diseases and how mortality risk was increased significantly from lack of vitamin A within these patients with their respective digestive issues which ceased after supplementation (which I will find for you all and insert here). I put two and two together (my night blindness) our systemic issues, similar but same side effect profiles...I went home and took 25,000 iu of beta carotene and I'll be damned but I haven't had not even a slight twinge out of my pancreas or liver, and its been almost a week. I'm back to eating and I'm just completely amazed. this is pretty earth shattering, because if you knew my pancreas like I know it, and a couple days of beta carotene have calmed it completely, is just incredible to me and it should be to you as well, if your dealing with IBS or digestive inflammation of sorts from Accutane.
I urge everyone to start from scratch, and focus on this vitamin A trail again. If our vitamin A readings are reading normal, then we need to look at what is wrong with the receptors. It could be that some of us are dealing with toxicity, some deficiency, but somethings askew.
^ add to your bookmark
Did you go on two rounds of tan?
Interesting. Very small amounts of beta-carotene once in a while can sometimes make me feel better. I get this warming sensation all over (my body is usually very cold) and my voice deepens temporarily. Any more than that and I get sides..
If i ingest some everyday, i get sides..its like i have a vit a deficiency borderline with vit a toxicity. It makes no sense. I agree with the poster above, something is wrong with the retinoic acid receptors..
How many of you also used topical Retin-A? It's basically All-trans retinoic acid, same substance accutane is converted to. If you search online, there's a lot of report of depression, suicidal ideation and other side effects from using the topical drug.
I used a lot of retin-A before, during and after I took accutane all the way into my late twenties. This makes sense actually. I had some depression issues in my teens that seemingly came out of nowhere that was only made way worse by accutane. It started with Retin-A..
Jesus...
I've been poisoning myself most of my life..
Quotehttp://www.jwatch.org/jd199603010000004/1996/03/01/topical-tretinoin-and-neurologic-side-effectsTopical Tretinoin and Neurologic Side Effects
NH ShearreviewingBernstein AL; Leventhal-Rochon JL.Ann Intern Med1996.This report describes a surprising association between topical tretinoin and neurotoxicity. A 39-year-old woman presented with complaints of headache, memory loss, and unsteadiness that interfered with simple daily activities. Examination showed truncal ataxia and dysarthria. The patient was suffering from untreated depression and chronic hepatitis C. Her liver enzymes were elevated by 30%, consistent with mild hepatitis, but her EEG was normal. The cause of the neurologic disease was unclear until the patient revealed that she had borrowed a friend's topical tretinoin (0.025%) to treat her own acne about four to six weeks before she visited the neurologist. She had been using large amounts of cream and developed dermatitis on her face. Two weeks after she stopped using the cream, her neurologic problems improved but her acne worsened. When she restarted the cream, the ataxia returned. The ataxia cleared four weeks after she again stopped using the cream, and she remained well for eight months. Her liver tests were unchanged.
The authors speculate that tretinoin was the cause of the neurotoxicity, since vitamin A and synthetic retinoids can cause headache, pseudotumor cerebri, irritability, ataxia, fatigue, depression, and psychosis. Factors that may have put this patient at risk are increased absorption of the retinoid through her inflamed, excoriated skin and increased availability of the retinoid because of reduced production of retinol-binding protein due to liver disease.
...........
Zinc and vitamin A interact in several ways. Zinc is a component of retinol-binding protein, a protein necessary for transporting vitamin A in the blood. Zinc is also required for the enzyme that converts retinol (vitamin A) to retinal. This latter form of vitamin A is necessary for the synthesis of rhodopsin, a protein in the eye that absorbs light and thus is involved in dark adaptation. Zinc deficiency is associated with decreased release of vitamin A from the liver, which may contribute to symptoms of night blindness that are seen with zinc deficiency
1 hour ago, MonsterDiesel said:How many of you also used topical Retin-A? It's basically All-trans retinoic acid, same substance accutane is converted to. If you search online, there's a lot of report of depression, suicidal ideation and other side effects from using the topical drug.
I used a lot of retin-A before, during and after I took accutane all the way into my late twenties. This makes sense actually. I had some depression issues in my teens that seemingly came out of nowhere that was only made way worse by accutane. It started with Retin-A..
Jesus...
I've been poisoning myself most of my life..
Wow yeah be careful what you rub on your skin after isotretinoin exposure,. Remember all toxins are stored in the skin fat cells thus rubbing reactivates the poison. Btw Hep C is another giant scam , read the book " Virus Mania" excellent .
Liver infllammation is real caused by toxins hep C however is not , no magic virus needed to explain liver toxicity , but it's a good way to make money for pHARMa , endless lies.
13 hours ago, macleod said:I urge everyone to start from scratch, and focus on this vitamin A trail again. If our vitamin A readings are reading normal, then we need to look at what is wrong with the receptors. It could be that some of us are dealing with toxicity, some deficiency, but somethings askew.
^ add to your bookmark
I've just started taking liquid vitamin A (not retinol, butRetinyl Palmitate). This is really to see if I get any improvement in night vision.
Also that '8 tips to repairing accutane' does mention the use of liquid vitamin A, which is obviously much easier to be absorbed by the body, as in our cases there are potentially issues with fab soluble vitamins. It's also possible to get liquid vitamin D3 which I may consider trying in future.
Answering an LDN question sent by PM for benefit of all:
> Did you start your initial does at 1.5mg at night? and how long did you wait to titrate your dose up and how high of a dose did you settle on?
1.5mg is WAY TOO HIGH. You dissolve the 4.5mg pill in 90ml distilled water, and have a 10 ml syringe. There's no reason to be aggressive, especially if you have a history of hypersensitivity. Start at 1 ml. Double it daily until you notice a sleep impact. Then back up off if your sleep has shortened or fatigue has increased. Stay in the sweet spot of excellent sleep as the dose gradually increases. There's NO BLOODY HURRY. After 2-3 months you might be at 4.5mg / night. I think I eventually got there. No reason to go higher.
If you start too high, you will screw up your sleep, which obviously makes everything worse. Just like improving your sleep makes everything better.
To understand its effect on sleep, compare to Huperzine A.
Can I guarantee it will work for you? No. Did it save me from a life not worth living? Yes.
3 hours ago, JosephBuchignani said:Answering a question sent by PM for benefit of all:
> Did you start your initial does at 1.5mg at night? and how long did you wait to titrate your dose up and how high of a dose did you settle on?
1.5mg is WAY TOO HIGH. You dissolve the 4.5mg pill in 90ml distilled water, and have a 10 ml syringe. There's no reason to be aggressive, especially if you have a history of hypersensitivity. Start at 1 ml. Double it daily until you notice a sleep impact. Then back up off if your sleep has shortened or fatigue has increased. Stay in the sweet spot of excellent sleep as the dose gradually increases. There's NO BLOODY HURRY. After 2-3 months you might be at 4.5mg / night. I think I eventually got there. No reason to go higher.
If you start too high, you will screw up your sleep, which obviously makes everything worse. Just like improving your sleep makes everything better.
To understand its effect on sleep, compare to Huperzine A.
Can I guarantee it will work for you? No. Did it save me from a life not worth living? Yes.
Sorry, what product are you talking about??
Anything that helps with sleep I'm interested in hearing about!!
The melatonin supplements aren't enough.
Hey! So I've been hearing that for accutane induced blushing and flushing I should focus on the liver? I hear that it has something to do with sympathetic nervous system? Lack or serotonin? Any experiences with this side effect? I feel like this is one that maybe not many people have? I would love some advice or stories.
Also, anyone heard or tried 5-HTP? I have heard that some people really help their digestive systems after accutane with it.
I was talking about LDN. I edited my post to reflect this.
I wouldn't say LDN is a magic bullet for sleep. Changes to sleep are just its only noticeable effect. If you are failing to thrive and sleeping poorly as a result, then you must heal the underlying health issue before sleeping well. So you should observe CHANGES to sleep quality, but not expect a great night's sleep right away, like you would with a sleeping pill.