Notifications
Clear all

Repairing the long-term damage from Accutane

 
MemberMember
45
(@cnb30)

Posted : 08/13/2016 1:39 pm

Just curious, but I'd like to hear from a range of people: how have you done with getting back atleast a personality, motivation, and a return to emotions? It's been over 3 months and the longer this goes on, the more tempted I am to end it. I've talked with doctors and therapists who tell me to go on because everyone eventually stops being depressed, but from the looks of here, I see no way out ever. I have been emotionally murdered.

Quote
MemberMember
1803
(@guitarman01)

Posted : 08/13/2016 8:33 pm

20 hours ago, TrueJustice said:
This is some really interesting info you're presenting here - thank you. Apart from getting full panel checks in recent blood tests, my focus was more on the whole "copper" issue that kept being brought up, might be time to check Calcium and Vit K again.

I remember some years ago getting extremely sore shins as if my bone structure was changing, scans at the time didn't find anything sinister but I could of investigated further. Doctors put vein issues down to lifestyle factors but my instincts tell me differently!!

Hard just to know where to go next with all this isn't it.!

I haven't forgotten about copper yet. I've been getting incredible nerve pains that are capable of reaching anywhere in my body. My feet, hands, teeth, pecker, face, nose, head. There are only a couple things this could be from the supplements I was taking. I've been making excuses that it's something else but I'm not sure.

Quote
MemberMember
37
(@umas)

Posted : 08/14/2016 2:53 am

13 hours ago, cnb30 said:

Just curious, but I'd like to hear from a range of people: how have you done with getting back atleast a personality, motivation, and a return to emotions? It's been over 3 months and the longer this goes on, the more tempted I am to end it. I've talked with doctors and therapists who tell me to go on because everyone eventually stops being depressed, but from the looks of here, I see no way out ever. I have been emotionally murdered.

Do you exercise? I don't know your full symptoms, I have to gather my willpower to exercise but then after I will better. Especially yoga is beneficial to me, clears my mind

Quote
MemberMember
157
(@tanedout)

Posted : 08/14/2016 5:20 am

Anyone tried vitamin E oil for sensitivity?!.. Just been reading a bit about PMO reboots, which I'm going to try (even though I'm currently starting on Freddds B12 protocol), but I've read a few people say rubbing in vit E oil has improved sensitivity..

Quote

Finally I found on the PMO site a suggestion of buying Vitamin E cream and applying it to my penis in hopes of increasing the sensitisation...the next time I had intercourse. I was super sensitive

http://www.rebootnation.org/forum/index.php?topic=10173.0

Quote

For sensitivity issues, I'd recommend Vitamin E cream or oil on the penis, I'm not sure if this is what did it for me... but I've noticed an improvement.

http://yourbrainonporn.com/age-25-my-sensitivity-back-only-20-days

Sounds like it could be worth a go so I'm going to get some naturally sourced vitamin e oil.

Quote
MemberMember
76
(@yetanotheraccutanevictim)

Posted : 08/14/2016 9:47 am

We are all toxic with aluminum and glyphosate primarily.

goo.gl/RnXPXsVisit this link and watch about 3-5 minutes of what Dr. Klinghardt is saying about aluminum testing.

These are my heavy metals test results from over the past couple years. Pay attention to aluminum. Compare the 2 tests to the Oligoscan I had done which is what Klinghardt uses (along with autonomic response testing).

Aluminum is the toxin EVERYONE is most toxic in. Aluminum and glyphosate are where you need to spend your time researching. Coffee enemas can get these out of the body BUT it may have a hard time getting it out of the brain. Liposomal silica and cilantro tincture are used for this.
I'm not sure if everyone here is awake to the reality yet but our people are being depopulated by the evil people in charge of the corporations. Vaccines, GMOs, chemtrails, fluoride, RoundUp, etc.. Please start researching this. It's really happening.
I suggest watching the entire 3 hour presentation by Dr. Klinghardt. It will explain a lot.

---

Klinghardt 2015:#t=17m15s

Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate
We analyzed the consequences ofaerial spraying with glyphosateadded to a surfactant solution in the northern part of Ecuador. A total of 24 exposed and 21 unexposed control individuals were investigated using the comet assay. The results showed ahigher degree of DNA damage in the exposed group(comet length = 35.5 m) compared to the control group (comet length = 25.94 m).These results suggest that in the formulation used during aerial spraying glyphosate had a genotoxic effect on the exposed individuals.
Genotoxicity Studies Performed in the Ecuadorian Population
The northeastern Ecuadorian border underwent the aerial spraying of an herbicide mix during the period of 20022007 and was supported by the Colombian government [13]. The Roundup mix presumably contained high doses of glyphosate plus a surfactant known as polyethoxylated tallowamine (POEA) and the adjuvant Cosmoflux 411F [14]. Glyphosate is an effective organophosphorous herbicide used worldwide [15,16] known to cause variable levels of toxicity in different organisms, such as the alteration of metabolic pathways, cytotoxicity in humans, metamorphosis alterations in amphibians, and abnormal development of sea urchin eggs [1722]. Such reports add to the already numerous concerns over the compound's many effects in the environment. The cytogenetic study of blood lymphocytes from individuals that lived in the area that endured the sprayings showed the absence of chromosomal aberrations two years after the last spraying in Ecuadorian soil [13].

chemtrails
Pilots, Doctors & Scientists Tell Truth about Chemtrails [Excerpts]oct 2014


ListentoallthatMarkMcCandlish,aformerDefenseemployee@11:15hastosay.
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=8&f=G&l=50&co1=AND&d=PTXT&s1=5,003,186&OS=5,003,186&RS=5,003,186

Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
in the International Journal of Environmental Research and Public Health

http://www.mdpi.com/1660-4601/12/8/9375

Ted Gunderson ex-FBI exposes chemtrails in 2011 (was murdered shortly after with arsenic)
Video was recorded on 12.01.11 (Jan 12, 2011). Died July 31, 2011.
http://beforeitsnews.com/alternative/2013/10/the-last-video-ted-l-gunderson-made-before-he-was-murdered-with-arsenic-2809068.html

Quote
MemberMember
359
(@dubya_b)

Posted : 08/14/2016 10:28 am

@yetanotheraccutanevictim You don't have to go deep into unrelated conspiracy theory territory. We're prime examples of the result of corporate greed.

.

Quote
0
(@Anonymous)

Posted : 08/14/2016 5:15 pm

Hi guys, haven't posted on here for a while but just wanted to share what I've tried and what's been working for me recently.
A little recap: I took accutane from around October 2014 to March 2015 and received the following side effects as a result (some of which didn't start until I had finished my course):
- Slight upper abdominal bloating, regardless of my overall weight (went from around 12.5 stone to 10 stone at one point and was still getting a bit bloated)
- Keratosis pilaris (KP) on arms and scalp
- Dry hair and scalp
- Also acne came back just as bad as before, but slightly different, related to the KP I think since they seem similar.
- Dry nostrils and ears.

Earlier this year I tried focusing on probiotics and was making my own milk kefir. I can't remember how high exactly the bacteria count was, maybe like 50 billion in a glass full. Anyway, I tried that for a month or two and didn't really get any results apart from my bowel movements were more regular. So I ended up stopping because there didn't seem much point in continuing. I've tried some other things too. Vitamin D, Taurine, B-12, L-Glutamine as some examples.

For the past month and a half I've been focusing on vitamin A, since reading that Fchwak had some success doing the same.
I've been getting all of my vitamin A from cod liver oil. Each 1000mg capsule contains the following:
- DPA: 100mg
- EPA: 80mg
- Vitamin A: ~2500IU
- VItamin D: 200IU

For the first month I was taking 12 capsules a day, equivalent to around 35,000IU of vitamin A. Even though I didn't have any side effects, I still thought that was maybe a bit too much so this past half month I cut it down to 9 capsules a day, or around 22,500IU of vitamin A.

Improvements I've noticed so far are as follows:
- Keratosis pilaris is beginning to clear, texture smoothing out as the keratin is purging, but a lot of hyper-pigmentation still remains on arms and some around hairline.
- Skin is starting to produce natural oils much better. As a result my scalp and hair are doing much better and my skin in general is smoother and less dry.
- Acne is purging and starting to clear. Also for a long time I've had these small bumps that never came to a head but now they are, which is possibly linked to the KP.
- My nose has been producing more mucous, which is helping me breath better. Ears have been producing wax much better than before. Had some dried pieces of earwax fall out, which I'm guessing were stuck in there from it being quite dry.
- Abdominal bloating has slightly improved, but I think that's the one issue that I might just be a bit paranoid over tbh (weigh 11 stone now for reference btw).

I've still got a ways to go until my skin is clear and all the hyper-pigmentation fades (which I don't even think it will entirely with the KP). But I would say that I've seen some definite improvements since taking cod liver oil.

I know there are a lot of sceptics on here when it comes to taking vitamin A to reverse the damage from accutane and I don't really have any evidence to back this all up, but it might be worth considering that the, or rather one of the solutions is maybe be a bit more straightforward than people think. I'm not trying to shit on the time and effort some of you put in to doing research on this, but whenever I come to this thread there's some new elaborate theory about how to reverse the damage and I rarely see anyone talking about any actual improvements they've had when pursuing these treatments. All I'm saying is a lot of you seem very dismissive about taking vitamin A, but it might be worth entertaining the idea.

Quote
MemberMember
223
(@gladiatoro)

Posted : 08/14/2016 9:55 pm

We will be forever ACCUSTAINED.

Quote
MemberMember
9
(@sacha_n)

Posted : 08/16/2016 1:50 pm

hi i have been following this thread for a while. AccuityDrane post on epigenetics made me think, what if accutane/finasteride slows body's processes, possibly via switching off/slowing down enzymes ? The enzymes affected can differ from case to case, that's why the symptoms are not always the same. Fatigue, digestion, mental issues, and at the same time normal blood tests.. looks like everything is just so slowed down. As long as i know enzymes are catalyst to chemical reactions inside our body, that's why i thought about them. So the 5ar is not the only enzyme affected, but many others too.

Quote
MemberMember
158
(@accuity_drane)

Posted : 08/16/2016 10:15 pm

21 hours ago, sacha_n said:

hi i have been following this thread for a while.  AccuityDrane post on epigenetics made me think, what if accutane/finasteride slows body's processes, possibly via switching off/slowing down enzymes ? The enzymes affected can differ from case to case, that's why the symptoms are not always the same. Fatigue, digestion, mental issues, and at the same time normal blood tests.. looks like everything is just so slowed down. As long as i know  enzymes are catalyst to chemical reactions inside our body, that's why i thought about them. So the 5ar is not the only enzyme affected, but many others too. 

Right, I think you are onto something. For a while I thought the apoptotic effects of Accutane were most relevant to our issues. I don't know if you have seen some of my early posts, but in one, I rehashed the research that demonstrates how one of Accutane's metabolites causes downregulation of the telomerase enzyme. (Thank you, Nathan Carr.) This is huge because telomerase is present in SEVERAL different types of cells. The telomerase enzyme modulates the rate of cellular death (it allows cells to reproduce more times before they die), but this is an emerging area of science so it may have other functions as well. Less telomerase = more cellular death = smaller brain, weaker skin, weaker intestines, bone loss, etc. The research is in; this is NOT speculation.  Basically, messing with telomerase is probably a terrible idea unless you have cancer, since cancer is essentially cellular reproduction run amok! I apologize if you were already aware of what I am speaking about.

All of that aside, we could talk for hours about the 5-Alpha Reductase Inhibition of Accutane, as you mentioned. But 5ar inhibition may lead to further complications that are "bigger than itself" so to speak. Take a look at this graph a user previously linked to:

5ar.png

Source: http://www.protocol-online.org/forums/uploads/monthly_08_2010/msg-19273-027408800 1282061244.ipb

So there you go. One system is tampered with, and it sets off a chain reaction of issues, JUST like messing with telomerase does. Basically, I feel like our condition is something complex like Chronic Fatigue Syndrome. We all probably have different things wrong with us, even if we were all exposed to the same mechanisms at one point. What's different is WHICH effects became a problem for our biological makeup, as there are so many potential sources with Accutane, as well as variation of symptoms for each possible source.

Again, depending on what you have read, this long-winded post may have added nothing to what you were saying. Or perhaps I missed your point by a few feet. Sorryyyy

Quote
MemberMember
9
(@sacha_n)

Posted : 08/17/2016 3:41 am

4 hours ago, ACCUiTy_drANE said:
Again, depending on what you have read, this long-winded post may have added nothing to what you were saying. Or perhaps I missed your point by a few feet. Sorryyyy

don't be sorry i appreciate your posts they're always informative. And as i haven't done so much research as some of you guys i may say things that you have already discussed and i missed it.
I see the diagram means that even if 5ari and dht return to normal levels, the body's still messed because of a chain reaction. My point was to be precise, can be some of our sides provoked by isotretinoin inhibiting other enzymes apart from 5ari and telomerase? And if that's the case, if these enzymes return to it's initial levels, can some symptoms be relieved? When we do blood tests, it's not often that we measure enzymes, do we? (though it can be tissue levels and i don't think it can be easily tested)As far i have tested my serum alkaline phosphatase some time ago, it was on low normal range.
As an example, one of my sides is rosacea, and one theory on it implies less functioning aldehyde dehydrogenase enzyme, which breaks down acetaldehyde (toxin produced by breaking down alcohol, but also by some bacteria and fungus).

Quote
john86, ACCUiTy_drANE, john86 and 3 people reacted
MemberMember
1804
(@truejustice)

Posted : 08/17/2016 6:13 am

So other than "Digestive Enzymes" what other form could we all take to improve our condition??

Quote
MemberMember
223
(@gladiatoro)

Posted : 08/17/2016 10:18 am

On August 14, 2016 at 3:15 PM, sam1w2e said:

Hi guys, haven't posted on here for a while but just wanted to share what I've tried and what's been working for me recently.
A little recap: I took accutane from around October 2014 to March 2015 and received the following side effects as a result (some of which didn't start until I had finished my course):
- Slight upper abdominal bloating, regardless of my overall weight (went from around 12.5 stone to 10 stone at one point and was still getting a bit bloated)
- Keratosis pilaris (KP) on arms and scalp
- Dry hair and scalp
- Also acne came back just as bad as before, but slightly different, related to the KP I think since they seem similar.
- Dry nostrils and ears.

Earlier this year I tried focusing on probiotics and was making my own milk kefir. I can't remember how high exactly the bacteria count was, maybe like 50 billion in a glass full. Anyway, I tried that for a month or two and didn't really get any results apart from my bowel movements were more regular. So I ended up stopping because there didn't seem much point in continuing. I've tried some other things too. Vitamin D, Taurine, B-12, L-Glutamine as some examples.

For the past month and a half I've been focusing on vitamin A, since reading that Fchwak had some success doing the same.
I've been getting all of my vitamin A from cod liver oil. Each 1000mg capsule contains the following:
- DPA: 100mg
- EPA: 80mg
- Vitamin A: ~2500IU
- VItamin D: 200IU

For the first month I was taking 12 capsules a day, equivalent to around 35,000IU of vitamin A. Even though I didn't have any side effects, I still thought that was maybe a bit too much so this past half month I cut it down to 9 capsules a day, or around 22,500IU of vitamin A.

Improvements I've noticed so far are as follows:
- Keratosis pilaris is beginning to clear, texture smoothing out as the keratin is purging, but a lot of hyper-pigmentation still remains on arms and some around hairline.
- Skin is starting to produce natural oils much better. As a result my scalp and hair are doing much better and my skin in general is smoother and less dry.
- Acne is purging and starting to clear. Also for a long time I've had these small bumps that never came to a head but now they are, which is possibly linked to the KP.
- My nose has been producing more mucous, which is helping me breath better. Ears have been producing wax much better than before. Had some dried pieces of earwax fall out, which I'm guessing were stuck in there from it being quite dry.
- Abdominal bloating has slightly improved, but I think that's the one issue that I might just be a bit paranoid over tbh (weigh 11 stone now for reference btw).

I've still got a ways to go until my skin is clear and all the hyper-pigmentation fades (which I don't even think it will entirely with the KP). But I would say that I've seen some definite improvements since taking cod liver oil.

I know there are a lot of sceptics on here when it comes to taking vitamin A to reverse the damage from accutane and I don't really have any evidence to back this all up, but it might be worth considering that the, or rather one of the solutions is maybe be a bit more straightforward than people think. I'm not trying to shit on the time and effort some of you put in to doing research on this, but whenever I come to this thread there's some new elaborate theory about how to reverse the damage and I rarely see anyone talking about any actual improvements they've had when pursuing these treatments. All I'm saying is a lot of you seem very dismissive about taking vitamin A, but it might be worth entertaining the idea.

I took fish oil for a few weeks and was paralyzedfor 3 days , btw it was Vit A free .
It was the retinol that $%^ed me over. Took me a week just to walk normal . So I would advice extreme caution with fish oil.

Quote
MemberMember
223
(@gladiatoro)
MemberMember
18
(@humanecyclone)

Posted : 08/17/2016 4:30 pm

17 hours ago, ACCUiTy_drANE said:

Less telomerase = more cellular death = smaller brain, weaker skin, weaker intestines, bone loss, etc. The research is in; this is NOT speculation. Basically, messing with telomerase is probably a terrible idea unless you have cancer, since cancer is essentially cellular reproduction run amok! I apologize if you were already aware of what I am speaking about.

Could you or someone else explain this to me? In my opinion, the telomere theory isn't something we should be worried about. Yes, Accutane suppresses the action of telomerase, but telomerase is only active in germ cells in an normal adult. The only case where this is different is when someone has cancer, and in this case, the telomerase gene is turned on and allows the telomere of the cancerous cells to never shrink (part of the reason by cancer cells don't die off on their on and continue growing/spreading). If telomerase were active in all somatic cells of a human, then we would never age due to the fact that our DNA would never reach that point in which it can't be transcribed into RNA then translated into a useful protein. To my knowledge, Accutane (or retinoic acid in general) doesn't affect the telomereitself, therefore, there really shouldn't be a reason to be worrying about the protection of our DNA (in all cells other than germ cells). Unless I'm missing something, I truly do not believe the telomere theory is something to worry about. On a side note, I bolded the suffixes of the telomere/telomerase not to be condescending but just for clarity.

The 5-ari theory makes a lot more sense, considering many of our problems could be linked to that (low T can result in brain fog, low libido, and you know the rest; however, I know it doesn't address the IBS/IBD problems, not sure about that). Also, since we are dealing with a feedback loop, I feel like there has to be a way to reverse the effects by "pushing" the loop int he right direction so to speak.

Quote
MemberMember
223
(@gladiatoro)

Posted : 08/17/2016 6:18 pm

Ibd/ibs is way more related to multiple courses of antibiotics.

Quote
MemberMember
158
(@accuity_drane)

Posted : 08/17/2016 8:21 pm

4 hours ago, HumaneCyclone said:
Could you or someone else explain this to me? In my opinion, the telomere theory isn't something we should be worried about. Yes, Accutane suppresses the action of telomerase, but telomerase is only active in germ cells in an normal adult.

This is usually the part where someone jumps in and says, "The details don't matter! Look at the body as a whole!" xD In any case, I appreciate the intellectual curiosity and did not find you condescending. The idea that telomerase is only relevant to cancer cells and germ cells is a myth. I have posted research in the past that delves into a bit.

"Deregulation of telomerase expression has been directly linked to human diseases (157). Human dyskeratosis congenita is a multiple-systems disease resulting from proliferative deficiencies that affects tissues such as skin, gut, and bone marrow, all of which require constant renewal and are normally highly regenerative."

If you do some Googleing, you will find that telomerase is found in stem cells and some somatic cells. It seems to play a role in repair in adults, especially through stem cells. (The relevance of stem cells in adults is a fairly new finding.) The research on this enzyme is quite murky and, at times, obscure. But when you consider how Accutane has been found to cause hippocampal cellular death and hypothalamic cellular death (part of brain that regulates hormones), it's hard to ignore the fact that Accutane metabolizes into a drug (namely, All-transretinoic Acid) that downegulates telomerase, and therefore, causes telomere shortening. Telomerase acts as a safeguard for telomeres and replenishes them. In fact, the previous article I linked mentions how individuals with lowered telomerase activity have shorter telomeres! For further evidence of Accutane's potential apoptotic effects, look at this:

". . . isotretinoin and its isomerization product ATRA induces upregulation of FoxO-signaling and exerts apoptotic effects in multiple cell types like the muscle, the bone and the brain."

It's possible that telomerase downregulation is not the sole driver in this body-wide apoptosis Accutane is capable of, but it is worth a thought. In any case, the long-term side effects of Accutane deserved to be looked at from a "cellular massacre" perspective.

4 hours ago, HumaneCyclone said:
The 5-ari theory makes a lot more sense, considering many of our problems could be linked to that (low T can result in brain fog, low libido, and you know the rest; however, I know it doesn't address the IBS/IBD problems, not sure about that). Also, since we are dealing with a feedback loop, I feel like there has to be a way to reverse the effects by "pushing" the loop int he right direction so to speak.

The problem is that many ex-Accutane and ex-Propecia users have testosterone levels that fall within the "normal" range, yet we seem to have every other symptom of low testosterone. In fact, many only report marginal improvements when they go on TRT or experiment with DHT directly. Assuming this 5ari theory is correct, this issue has less to do with total testosterone/DHT levels and more to do with a fundamental change in the way the body responds to androgenic hormones. At least, that's how I understand it.

But you have to be careful, because brain fog can have a thousand sources. You mentioned the gut issues. A lawsuit brought against Roche a few years ago revealed internal studies conducted by Roche that demonstrated how Accutane can erode the intestinal tract. Not only can this bring on IBD, but it could potentially mess with the microbiome and lead to new food sensitivities. Self-hacked has an excellent article on brain fog. A lot of it relates back to diet. He even mentions the hypothalamus's role, which brings me back to Accutane's apoptotic effects on that system. Haha, this puzzle is ridiculous!

Quote
Dubya_B, HumaneCyclone, Gladiatoro and 6 people reacted
MemberMember
223
(@gladiatoro)

Posted : 08/17/2016 11:14 pm

You guys should watch the documentary VAXXED.

Quote
MemberMember
0
(@abi72)

Posted : 08/18/2016 2:23 am

Received this as a PM but have permission to share:

The things that I am 99% sure have worked at helping symptoms are:

-creatine
-taurine
-BCAAS 
 
Things I can only be 85% sure worked, but would not hesitate to do again, also more long term.
-25,000iu vitamin a up to 6 weeks 
-10,000iu vitamin d up to 6 weeks
-1000mcg vitamin k
-1000iu vitamin e
 
Things I did but would hesitate to do again
- 100,000iu on average day for 6 weeks including 1.5m IU over 3 days
 
Currently I'm feeling 99%, my hamstring which I tore nearly 3 weeks ago is good. I ran out of vitamin k about 2 weeks ago and I might be missing that, haven't been having anymore wet dreams sadly. I honestly feel the best I have felt for nearly 5 years when I was 16, seems like the worlds at my finger tips again.
 

I have been really busy with work and sport, training 20 hours a week and working 30 on top of that, as I decided to take a year off study to get some real world experience and pursue my sporting ambitions. The megadosing Vitamin A really screwed over my preseason which is why I would hesitate to do again, but in the long term it may be worth it, at this stage I am just wishing I did it a few months earlier before preseason started, but some studies warn of permanent effects... Just letting you know both sides 
 
All my tendons and ligaments aren't bothering me, so I have more trust that my body can take the load then I have had in years. Basically I feel young again, 20 years old in a 20 year old body instead of a 40 year old one.
I'm also cutting weight, have dropped four kilos (mainly water some fat as well though) in the last 2 weeks, which may explain the lack of wet dreams because I am relatively catabolic, as well as the fact I am "relieving myself" several times a week as well.
 
Sorry for  the he late reply, hoping to snatch some sleep now |::) 

feel free to share what I've said here on the forum, I'll catch it up at some stage when I find some time this weekend. Spend the ~ $60 to get creatine 3-5g day, taurine 2-3g day and BCAAs at whatever they recommend. If you are worried about the vitamin dosages I set start taking them at 20% of what I said above, that is safe for sure but will alleviate any chronic deficiencies you may have. At some stage I'm going to look into biotin as well, also look at what WaldenRev is doing, he is pretty on the ball and has been doing it longer than me 

 
 
Quote
MemberMember
2
(@dontcrybaby)

Posted : 08/18/2016 9:00 am

Hi guys,help me please!

Maybe you will have any ideas what hadhappened to me. Check mythread out please. CLICK HERE.I described my whole situatioin there.

  • weight - about 50kg
  • 40mg during 3,5 months
  • 60mg during 1,5 months
  • total dosage: 7200 mg
  • 138mg/1kg

My doctor put me on Accutane after my hormonal "breakout". However I should have never been on isotretinoin. My derm is an idiot. I had only a few pimples before it. During "treatment" my face became a mess.
I had huge cysts (I never had cystc till acutanne actually) which left me with scars. Also, my skin texture had changed dramatically. I've got plenty of ice pick scars on my forehead and open pores on both my forehead and cheeks and random scaring. My cheeks are burning also when I touch them! I cannot even wear my glasses because it hurts. What's more - my face is swelling a lot. It's really embarrassing. Iwonder if my skin texture will improve by the time? Will it get back to normal or it's irreversible?

I've got 2 ideas:
1) Maybe my skins look like that because it's just dehydrated? I hope it is not pernament.
2) Is it possible that either Accutane or Retin-A (retinoids in general) causes rosacea disease? Because I think I might haverosacea symptoms, including red and irritated skin.

I'm on antibiotic (azithromycin) since I started 60mg/per day. Which is about 3 moths. I stopped taking Accutane almost 2 months ago. Year ago my skin was flawless.And I look disgusting now. Withoutantibiotics I am still getting new pimples. What the hell has happened with my face?

My doctor allowed me to take 60mg per day because I didn't even havechapped lips (only dry eyes) and I wanted to stop this nightmare ealier. He recommend me not to stop the treatment. The biggest mistake of my life.

I'm going to theuniversity hospital next week but I doubt if they can help me and figure out why I look like a shit after treatment.
Accutane is supposed to shrink pores and get rid of acne. How is it even possible that I have exactly opposite effects and zero benefits from taking it?

Quote
MemberMember
18
(@humanecyclone)

Posted : 08/18/2016 10:15 am

13 hours ago, ACCUiTy_drANE said:
This is usually the part where someone jumps in and says, "The details don't matter! Look at the body as a whole!" xD In any case, I appreciate the intellectual curiosity and did not find you condescending. The idea that telomerase is only relevant to cancer cells and germ cells is a myth. I have posted research in the past that delves into a bit.

"Deregulation of telomerase expression has been directly linked to human diseases (157). Human dyskeratosis congenita is a multiple-systems disease resulting from proliferative deficiencies that affects tissues such as skin, gut, and bone marrow, all of which require constant renewal and are normally highly regenerative."

If you do some Googleing, you will find that telomerase is found in stem cells and some somatic cells. It seems to play a role in repair in adults, especially through stem cells. (The relevance of stem cells in adults is a fairly new finding.) The research on this enzyme is quite murky and, at times, obscure. But when you consider how Accutane has been found to cause hippocampal cellular death and hypothalamic cellular death (part of brain that regulates hormones), it's hard to ignore the fact that Accutane metabolizes into a drug (namely, All-transretinoic Acid) that downegulates telomerase, and therefore, causes telomere shortening. Telomerase acts as a safeguard for telomeres and replenishes them. In fact, the previous article I linked mentions how individuals with lowered telomerase activity have shorter telomeres! For further evidence of Accutane's potential apoptotic effects, look at this:

". . . isotretinoin and its isomerization product ATRA induces upregulation of FoxO-signaling and exerts apoptotic effects in multiple cell types like the muscle, the bone and the brain."

It's possible that telomerase downregulation is not the sole driver in this body-wide apoptosis Accutane is capable of, but it is worth a thought. In any case, the long-term side effects of Accutane deserved to be looked at from a "cellular massacre" perspective.

The problem is that many ex-Accutane and ex-Propecia users have testosterone levels that fall within the "normal" range, yet we seem to have every other symptom of low testosterone. In fact, many only report marginal improvements when they go on TRT or experiment with DHT directly. Assuming this 5ari theory is correct, this issue has less to do with total testosterone/DHT levels and more to do with a fundamental change in the way the body responds to androgenic hormones. At least, that's how I understand it.

But you have to be careful, because brain fog can have a thousand sources. You mentioned the gut issues. A lawsuit brought against Roche a few years ago revealed internal studies conducted by Roche that demonstrated how Accutane can erode the intestinal tract. Not only can this bring on IBD, but it could potentially mess with the microbiome and lead to new food sensitivities. Self-hacked has an excellent article on brain fog. A lot of it relates back to diet. He even mentions the hypothalamus's role, which brings me back to Accutane's apoptotic effects on that system. Haha, this puzzle is ridiculous!

Ahh, I see now. Thanks for the great explanation, even though it definitely something I don't want to be hearing :/. Although, hatetane's post was definitely timed well because it definitely brought some much needed hope .

Quote
MemberMember
45
(@cnb30)

Posted : 08/18/2016 12:49 pm

Does anyone here get like mini seizures in the back of their head and feel really awkward and twitchy (like when you turn your head you just twitch it in different directions)?

Quote
MemberMember
22
(@quietsoldier)

Posted : 08/18/2016 2:33 pm

So if the 5ari theory is correct, taking accutane again would resensitize the receptors. Did anyone who took multiple course of it experience a resurgence of their libido when they were put back on it?

Quote
MemberMember
18
(@humanecyclone)

Posted : 08/18/2016 4:41 pm

2 hours ago, QuietSoldier said:

So if the 5ari theory is correct, taking accutane again would resensitize the receptors. Did anyone who took multiple course of it experience a resurgence of their libido when they were put back on it?

I think people have talked about this before, but I haven't read of anyone having success with that. However, I have read of people getting libido related issues after taking a second or third course, but not after their initial one.

Quote
MemberMember
0
(@abi72)

Posted : 08/18/2016 5:04 pm

Hi I have spoken to a couple of guys who suggest that HRT works for some but not for others. I haven't spoken to anyone who has
been able to clarify if HRT has been beneficial or not.
It seems that Dr Goldsteine uses clomid for PAS. Whether he has had any success I do not know. I have seen a couple of guys who say clomid does not help but we need to hear from people who may have had some success.

Dr Shippen, one of the doctors leading the charge for PFS, has suggested HCG therapy and I wonder if anyone has tried this.
http://www.excelmale.com/showthread.php?435-The-Use-of-HCG-to-Prevent-Reverse-Testicular-Shrinkage-and-Preserve-Fertility)

Generally young men are unaware of their T and other hormone levels before taking accutane, but it is well documented that these are reduced
and or affected by accutane. If your T levels are on the low side it is most likely that the level was higher before accutane.

Has anyone had success in balancing hormones?

I think it is really important not to assume that everyone has tried HRT with or without success.

We need more data on this so if anyone can speak about their experiences we might be able to get some clarification.

I have had PM's from a couple of guys who were wiped out for over a year without any major treatment and recovered low libido and ED.
Healthy lifestyle changes and exercise did the trick for them. Quite a few guys seem to believe that ED resolves itself in time but frustratingly
i haven't been able to form a conclusive picture or timeframe regarding this.

More than one guy has said to me that they don't really care about their low libido or ED saying that it is the least of their worries, this I find very scary but maybe some of you might agree with this.

I know that many of you have so many issues and this forum doesn't really lend itself to specific problems but it really would be great
if we could get some specific information on sexual problems.

So if anyone has any test results they would care to share or HRT info it might really prove helpful to others.

Anyone looking to get testing done, I suggest starting with the short list that PFS forums suggest. I can post this if needs be.

I really hope that for all the guys suffering and concentrating on this specifically that we can get some answers that will prove useful.

Thanks guys.

More info on HCG
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214853/

Quote