Acne.org Products
Go and ingest 60 gram of good Rick SImpson oil, it will help you with alot of mental sides.
49 minutes ago, cnb30 said:So you're simply saying "Live with this"? I'm not gonna do that. This isn't "depression talking" either. This is a very upset 19 year old who needs justice to be served.
1 hour ago, cnb30 said:So you're simply saying "Live with this"? I'm not gonna do that. This isn't "depression talking" either. This is a very upset 19 year old who needs justice to be served.
You mean antibiotics honestly I think after much research that they do WAY more long term damage than isotretinon especially multiple courses will cripple / destroy the immune system / GUT.FACT
2 hours ago, cnb30 said:So you're simply saying "Live with this"? I'm not gonna do that. This isn't "depression talking" either. This is a very upset 19 year old who needs justice to be served.
Nah, I'm not saying "live with this". Just try not to dwell about it too much, while at the same time of course you shoud try to repair what's have been damaged. I just think that positive ot at least neutral attitude is pretty important in healing and repairing body.
PS Although to be completely honest you need to acknowledge what happened and that you have to live with it at least some time. It's not surrendering it's just accepting reality. From there you can try to repair what can be repaired. It can e sad, but believe me - I'm struggling five years and I started to move forward when I accept what happened. It's not like I have time machine to change what happened. Although then I wouldn't have reason to go back so time paradox at it's finest :>
39 minutes ago, Umas said:Nah, I'm not saying "live with this". Just try not to dwell about it too much, while at the same time of course you shoud try to repair what's have been damaged. I just think that positive ot at least neutral attitude is pretty important in healing and repairing body.PS Although to be completely honest you need to acknowledge what happened and that you have to live with it at least some time. It's not surrendering it's just accepting reality. From there you can try to repair what can be repaired. It can e sad, but believe me - I'm struggling five years and I started to move forward when I accept what happened. It's not like I have time machine to change what happened. Although then I wouldn't have reason to go back so time paradox at it's finest :>
I'll attemp to, I'm going to college soon, but if I fail out and/or if nothing improves, I'll probably be dead soon. I'm not living with this shit, and I'm not going to accept this at all especially when there are corrupt individuals directly at fault here who lied and cheated me into this position. Honestly, the worst thing anyone can do is just accept it, because then, more people fall into the trap.
1 hour ago, cnb30 said:I'll attemp to, I'm going to college soon, but if I fail out and/or if nothing improves, I'll probably be dead soon. I'm not living with this shit, and I'm not going to accept this at all especially when there are corrupt individuals directly at fault here who lied and cheated me into this position. Honestly, the worst thing anyone can do is just accept it, because then, more people fall into the trap.
Maybe that's my poor skill of english but that's not what I meant. Accepting is not surrendering. Accepting still mean to fight to heal and repair, and warn others but with different attitude. For long time I was in denial, or asking "why me" or "how could I be so stupid", and "if I not heal, then rest of life doen't matter" but that's not changing anything. Accepting is different from surrendering because when you surrender you think that nothing can be changed and that will be all the time. And it doesn't even matter that there are corrupt individuals at fault. Thinking about it only make it worse for you. They steal enough from you, why giving them any more power over you? Fact is that thought like that will stress you, and stress is not good for healing or health overall. If you want to maximize you chances for healing, you have to deal with your thoughts and emotions also.
The Bad Side of Probiotics
Before we get into the good stuff we have to touch on Bifidobacteria. Its a hot topic in the SCD community for the reason that it can take over and cause health problems in some cases.
It is a beneficial bacteria, but the problem is, its just not a good neighbor at times. So, sometimes it can overgrow in and of itself.
So just to be on the safe side we usually recommend avoiding it in the beginning of the healing journey, but later on it can really help
Now onto the important part how to get started using them.
How to Start Using Probiotics the Right Way
Step 1)Your safest bet to start healing isLactobacillus acidophilus. GI Pro Scdophilus is great because its non-dairy, SCD legal, very high quality, and has a long shelf life.
You can find out more about it here: http://www.giprohealth.com/scdophilusnext.aspx
Step 2)Start low and work your way up. For example, if you go with Scdophilus from GI Pro Health, they have a 3 Billion CFU pill and a 10 Billion CFU pill. So you could start by taking 1 of their 3 Billion CFU pills per day and work up slowly to 30 to 40 billion CFUs per day by moving up to the 10 Billion CFU pills.
(For best results: take them 30 minutes before breakfast right when you wake up or atleast two hours after a meal right before bed. Thats the best odds to get live cultures past the stomach pH and into the intestines.)
8 minutes ago, cnb30 said:Have any of you guysreallyseen any true benefits from supplements, pro-biotic a, etc, or is this just part of an endless quest and more of a placebo thing?
I'll get back to you on that. Typing on my phone is a pain in the ass.i think gut health can affect alot. That's why people feel so up and down on a daily basis. Because things are affecting them more then they should. And it's not just in your head
5 hours ago, Walden Rev said:Go and ingest 60 gram of good Rick SImpson oil, it will help you with alot of mental sides.
Do you have any evidence for this? Not to sound skeptical, but have you personally tried it?
6 hours ago, Walden Rev said:Piracetam,
Anyone here tried piracetam? It give me chapped lips again and intense muscle pain.
They use it to correct brain damage
Yes, I have used piracetam on many days for several years. I don't honestly know if it helps much more than a placebo. Because of it's low cost, and supposedly low toxicity, I wouldn't hesitate recommending trying it to anyone debilitated with cognitive symptoms. Based on my experience it certainly won't cure post-accutane syndrome, or do anything for emotional symptoms, but if you have brain fog it may make it easier to concentrate and be productive in spite of it...I didn't notice any unusual physical symptoms like you did however.
9 hours ago, Walden Rev said:Piracetam,
Anyone here tried piracetam? It give me chapped lips again and intense muscle pain.
They use it to correct brain damage
I tried it for a few days and noticed minimal benefits. I never did experiment with higher doses like some do, because Piracetam can actually be neurotoxic past a certain threshold. You could say that about any substance, but Piracetam seems to give amazing, acute benefits to certain people at high doses, even though issues may be looming around the corner. Also, Google "Piracetam" and "brain fog." A subset of people seem to develop CHRONIC (therefore a mere choline deficiency can likely be ruled out) brain fog from Piracetam. Although this may be rare, I tend to believe people when they say a drug ruined their lives. I'm sure a handful of people here can relate to that perspective. 
3 hours ago, cnb30 said:Have any of you guys really seen any true benefits from supplements, pro-biotic a, etc, or is this just part of an endless quest and more of a placebo thing?
Yes, my digestion is in a much better place now than it was a year ago thanks to probiotics. It is one of the few side effects I have actually had any success managing. I doubt the probiotics have done anything for my Accutane-induced mental issues though. The chronic brain fog, anhedonia, and slower mental processing are what impact me most. I have improved my cognitive fluency through practice. But that is simply me adapting. Granted, I DO have days that I feel decent days mentally, but I'm yet to see reliable progress mentally.
2 hours ago, yetanotheraccutanevictim said:Going to get blood taken tomorrow. Any tests I should get besides the usual stuff?
I recently got my cholesterol checked and it was extremely low. If you suffer from the mental sides, I'd be curious to hear what your levels are.
You guys are going to love this, but I feel this needs to be documented here so Im going to paste the whole thing. Some of you doubters, you owe it to yourselves and other people to at least read the first couple of paragraphs. This isnt one of 200 symptoms. This is the 200 symptoms. This is going to have to cover multiple post.
[Edited link out]
Candida
This is a work in progress and is being updated regularly. Check back regularly, as I will be steadily improving the site and adding more information.
Candida Overgrowth
[Edited link out]
Moderate amounts of candida (and other yeast) live in every one of us without causing any harm, but when given free rein to grow unchecked, e.g. by wiping out the surrounding bacteria with broad-spectrum antibiotics, candida can change into its fungal form and spore through the intestinal wall into the rest of the body. Once through, it rampages around the body producing a multitude of symptoms.
[Edited link out]
All it needs for Candida to invade your gut is for something to kill off the normal flora; the bacteria that aid digestion and protect the gut from yeast. Once the flora are damaged, yeast will invade. In ideal circumstances, Candida can double in quantity every half hour, so it takes very little time for it to populate a damaged intestine. Hormones, antibiotics, environmental toxins, heavy metals and poor dietary habits can all contribute or cause a yeast infection. Once in the gut, candida creates an environment that prevents the normal flora from repopulating. The lack of flora causes mal-digestion of certain sugars, carbohydrates, minerals and trace nutrients and leaves food to rot in the gut, creating an ideal environment for the Candida.
According to the conditions it finds, candida can exist in 3 forms; a budding, multiplying yeast, a hyphae form, which penetrates the gut wall in search of nutrition in the blood and as highly invasive spores, which penetrate the gut wall to be transported in the blood stream to other organs.
Once the yeast has overgrown the gut, malnutrition will result, in the form of vitamin and trace nutrient deficiencies. In addition, the constant presence of a pathogen will stimulate the immune system 24 x 7 x 365, eventually causing immune deficiency (as found in CFS) and severe fatigue. Victims will experience a multitude of symptoms caused by malnutition, an impaired immune system, toxins from the yeast's metabolic processes and from the physical presence of the yeast."
Yeast make a number of chemical compounds which are then picked up and absorbed into the body. These compounds are quite toxic to the nervous system. These compounds include toxic alcohols and aldehydes, as well as the powerful nervous system poison hydrogen sulfide (editor's note: this is a totally different substance than hyrodgen sulfate). Alcohols depress the nervous system and at least some aldehydes are anesthetic agents, which of course put the brain to sleep. These chemicals slow the brain down so that the brain no longer works correctly. These chemicals should be cleared by the liver so that these chemicals never reach the brain.
[Edited link out]
Candida mainly exists in two forms: a round yeast that remains in the colon and is actively reproducing and the other in its fungal form that 'eats' through the intestinal wall and travels via the blood to any site in the body. Sugar (in many forms) activates candida metabolism and its by-products are neurotoxins (toxins that damage or destroy nerve tissue) such as formaldehyde, and alcohol. The nervous system can become deranged with candida due to specific neurotoxins. Autism is one example of this. Metabolites of candida are found in urine samples of children with autism. Specific bacteria and fungi migrate from the large to small intestines to break down undigested carbohydrates. Candida is also known to impair immune functioning. Approximately 80% of our immune system lies within the intestinal walls. What you do to your intestines directly affects your 'immune' system. The immune system will respond to candida and its by-products along with food molecules that escape into the bloodstream by secreting histamines causing classic symptoms of allergies and intolerances.
[Edited link out]
Occasionally, Candida overgrowth occurs throughout the body including the liver and blood. Once in the blood, the fungus can be carried anywhere in the body resulting in a myriad of health problems including frequent urinary tract infections, respiratory problems, gastrointestinal and liver problems, food allergies, decreased immunity, frequent or chronic fungus infections of the skin and nails, and weight gain. This condition is referred to as Systemic Candidiasis (also known as candidosis and moniliasis.)
Note: This doesnt match at all, while the other ones do quite well.
REFERENCE:Wikipedia-Candidiasis
Candidiasis, commonly called yeast infection or thrush, is a fungal infection of any of the Candida species, of which Candida albicans is probably the most common.
Yeast organisms are always present in all people, but are usually prevented from "overgrowth" (uncontrolled multiplication resulting in symptoms) by naturally occurring microorganisms... However, when it gets out of balance with the other "normal flora", such as lactobacilli, an overgrowth and symptoms can result. Pregnancy, the use of oral contraceptives and some antibiotics, and diabetes mellitus can lead to an increased incidence in yeast infections.
In immunocompromised patients, the Candida infection can become systemic, causing a much more serious condition, fungemia.
REFERENCE:Wikipedia-Fungemia
Fungemia is the presence of fungi or yeasts in the blood. It is most commonly seen in immunosuppressed or immunocompromised patients with severe neutropenia, oncology patients, or in patients with intravenous catheters.
The diagnosis is complicated, as routine blood cultures have poor sensitivity. Treatment involves use of antifungals, eg. fluconazole or amphotericin.
The two most important risk factors are:
Use of broad-spectrum antibiotics
Colonization by fungi (see eg. candidiasis)The most common pathogen is Candida albicans, causing roughly 70% of fungemias, followed by Torulopsis glabrata with 10%, and Aspergillus with 1%. However, the frequency of infection by T. glabrata, Candida tropicalis, C. krusei, and C. parapsilosis is increasing, especially when significant use of fluconazole is common.
Symptoms of Candida
[Edited link out]
Common symptoms of Candida
A minority of suffers have numerous symptoms; the vast majority have thrush + a few others; not every sufferer has thrush.
Group 1: The damage to the intestinal wall allows undesirable toxins to permeate into the bloodstream. This condition called leaky gut syndrome' often leads to:
food allergies and intolerances
migraines
foggy brain
muscle achesGroup 2: Once through to the rest of the body, candida has the ability to disrupt the endocrine system causing symptoms such as:
thrush
cystitis
PMS
menstrual irregularities
joint pains
asthma
hayfever
sinusitis
fungal infections of the nails/skin e.g. athlete's foot
weight gain or weight loss
ear infections
chronic tiredness
allergies
sensitivity to perfume, tobacco smoke and petrolGroup 3: Symptoms in the intestines include:
bloatedness
flatulence
diarrhoea and/or constipation
itchy anusIn addition, candida involvement has been implicated in some cases of other illnesses e.g. ME/CFS, Endometriosis.
[Edited link out]
Candida leads to brain fog because having systemic candidiasis means you're constantly drinking alcohol, as yeasts convert sugars into alcohol. This also congests the liver, another major co-factor in brain fog. If the liver, the filter for blood, is congested, it cannot take toxins out of the bloodstream fast enough. These toxins will pass the blood-brain barrier of the brain and deplete the brain of oxygen and glycogen.
[Edited link out]
Candida yeast ferments dietary sugars into liver-toxic acetaldehyde in the process of turning sugar into energy. Candida also appears to increase gut and urinary levels of ammonia, another liver toxin.
[Edited link out]
Candida overgrowth can produce a large number of symptoms. Among them are headaches, migraines, bad breath and rectal itching. Mood swings, canker sores and persistent heartburn. Muscle and joint pain, numbness and tingling sensations in the face or extremities.
Also acne, night sweats, sore throat, nagging cough and clogged sinuses. PMS and thrush; a yeast infection of the mouth causing a burning tongue and white spots on the tongue and in the mouth, also cystitis and fungal infections of the skin and nails. Kidney and bladder infections, arthritis, flatulence (gas) gastritis, diarrhea, and chronic constipation. Colitis and ulcers in the digestive tract, leaky gut syndrome, female disorders; including sterility, fibrosis or pregnancy problems and vaginitis. Plus the Male disorders; prostatitis and impotence.
Further symptoms are allergies, hormonal imbalance, heart problems and poor memory / balance. Earaches and ear infections, asthma, sinusitis, fluctuation in blood sugar levels and meningitis.
These toxins represent a great strain on the liver. Which can no longer adequately detoxify the body, causing extreme fatigue and a general feeling of discomfort. Depression, hyperactivity and indigestion join the previously mentioned symptoms. These various symptoms can be caused by the fungus candida albicans. Which produces almost 100 different toxins.
[Edited link out]
What are the Signs and Symptoms of Candida Overgrowth?
Gas and Bloating
Some symptoms of Candida overgrowth are localized in the digestive system, other symptoms are found in different locations in the body. Just as bread rises from yeast due to carbon dioxide production from fermentation of carbohydrates, Candida also produces carbon dioxide in the intestine. The result is persistent gas and bloating.
Brain Fog
Another by-product of Candida is acetaldehyde, a poison that is converted into ethanol by the liver. As yeast multiplies and produces more acetaldehyde, the blood alcohol level rises, resulting in symptoms associated with drunkenness, including impaired mental and physical functioning.
Infections
As yeast moves through the holes in the mucosal barrier and travels throughout the bloodstream, it produces such disorders as chronic ear infections and sinus infections. Physicians commonly prescribe antibiotics for fungal ear infections and sinus infections, which can make the condition worse by further destroying the good bacteria in the body. Candida overgrowth is also responsible for fingernail and toenail fungus and recurrent vaginal yeast infections.
Fatigue
Excess toxins produced by Candida can leave a person feeling lethargic and fatigued and sometimes with joint and muscle pain. Quite simply, the body must exert energy to cleanse itself, and when Candida is overgrown, the toxic load on the body increases. Sugar and carbohydrate cravings are a common Candida symptom as yeast feeds on sugars. The result can be an increased desire for sugar, which in turn causes a rollercoaster effect in your energy.
Candida can cause autoimmune diseases due to the fact that Candida can increase the permeability of your intestinal lining, also known as "leaky gut syndrome." With leaky gut, large undigested food molecules can enter your bloodstream which the body recognizes as a foreign material. When this occurs, the immune system attacks the food. The immune response involves making antibodies, which are the equivalent to the immune system's memory. The next time the same type of food enters the body, the immune system remembers and attacks again. The result is a sudden food allergy or sensitivity to commonly eaten foods. Toxins made by candida also signal an immune response to produce antibodies. An autoimmune disorder occurs when the immune system reacts with a hyperactive response to the digestive process and the toxins within it. The hyperactive immune system begins to attack the body's own tissues. There are about 80 known autoimmune diseases. Among these diseases are: rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, Chrohn's disease, diabetes, Lupus, and multiple sclerosis.
[Edited link out]
Following are a few classic symptoms of candida overgrowth:
Gastrointestinal: indigestion, gas, bloating, inflammatory bowel diseases, diarrhea, constipation, heartburn, bad breath and thrush (coating on tongue).
Physical: numbness, burning or tingling; painful, swollen, stiff joints; muscle aches and tension, nasal congestion, chronic headaches, blurred vision, shortness of breath, chest pains, dizziness, sinusitis, and chemical sensitivity.
Mental/Emotional: depression, mental confusion, irritability, insomnia, nervousness, anxiety, disorientation, impaired decision making, low energy, fatigue, hyperactivity, chronic ear infections and poor memory.
Skin: white fungal skin patches like dandruff, acne, athlete's foot, anal itch, diaper rash, psoriasis, dermatitis, finger and toenail infections, unpleasant body or hair odour, genital touching in infants and young children, skin rashes and behavioural problems.
Sexual: vaginitis, discharge, itch, bladder infection, menstrual irregularities, pain, cramps, lowered libido, infertility, impotency, prostate problems.
Urinary: frequent urination, burning, fluid retention and edema.
[Edited link out]
Weight problems, vaginal yeast, athlete's foot, scalp problems such as dandruff, nail fungus, joint inflammation, poor immune response, headaches, allergies, shingles, oral thrush, canker sores, excessive sneezing, poor memory, brain fog, tooth plaque, hemorrhoids, throat mucous, and skin eruptions like acne, are all connected with Candida overrun And "Sleep" in the corner of the eye indicates a Candida problem, so does a coated tongue.
Most allergies can be eliminated with the elimination of Candida overgrowth. The waste products of Candida flood the lymph system with more toxins than it can handle, and the body develops allergies. Candida overgrowth drastically reduces digestion, allowing undigested food into the blood stream. This undigested food causes an immune response, the making of an allergy.
Many reoccurring sinus problems are Candida overgrowth. Toxic bowel from Candida leaks toxins into the sinus cavities. The body rids itself of these toxins with a "runny nose."
Headaches, particularly migraine, may be Candida. Bowels overrun with Candida form excess mucous as a protection. This causes a very toxic, dehydrated lymph system. The immune system's response is to build antigens that flood the lymph. Toxic dehydrated lymph will give you a headache.
My favorite symptom, bloating and gas, can come from Candida. When high glycemic foods are eaten, the Candida feasts. A by-product of this is gas, just like the making of beer. The bad breath and gas makes for interesting company, probably lets you know who your friends are, too.
Candida may cause gum problems by weakening the gum below the tooth line. As stated earlier, most excess plaque is Candida related. Toe fungus is Candida. Losing a toenail to fungus is like losing your teeth to it.
[Edited link out]
What are the symptoms of Candida Overgrowth?
The symtoms are many and are so varied and manifest as so many other problems that you would not believe that they can be caused by the same thing. Some symptons are listed below, if you only have more two or three of these symptoms on a regular basis then you may have a problem with candida overgrowth:* Recurring headaches/ migraines.
* Rashes, itching skin.
* Thush - oral/vaginal.
* Abdominal bloating. Intestinal bloating can also be caused by 'swallowing air' and the simple cure is 'catch yourself doing it and stop it'.
* Recurrent indigestion.
* Dry mouth or throat, constantly having to clear throat when speaking.
* Joint pain.
* Brain fog, fuzzy thinking.
* Feeling 'blue', mood swings.
* Hangover symptoms after bread/cakes.
* Sinus problems.
* Athletes foot type fungal problems.
[Edited link out]
12) As touched on above, pioneering researchers believe that depression is another symptom of Candida overgrowthor more specifically, the 80 plus poisonous toxins and neurotoxins that candida yeast can produce inside the body. It is this toxic waste that they believe to be the primary cause of depression, especially for the chronically ill. These toxins can mimic and interfere with many of the body's hormones. When this happens, feelings of intense depression may be induced.8,9,10
In addition to the toxins put off by the yeast itself, Candida also survives by manufacturing toxic substances from refined carbohydrates and sugars in the digestive system. Hypersensitivity to these Candida yeast toxins, the most harmful of which is acetaldehyde (a by-product of alcohol and the chemical that naturally causes a "hangover"), can lead to anxiety, depression and impaired intellectual functioning.
Causes of Candida Overgrowth
[Edited link out]
Contributory factors
The popular perception is that candida is the consequence of antibiotics usage.The medical profession dismisses this as fantasy, saying that antibiotics could not have that effect in a healthy individual. But it may be that antibiotics act as the final straw' where health has already been compromised, most probably by one or more of the following:
use of the contraceptive pill or HRT
use of natural progesterone cream
use of other steroids (hydrocortisone, prednisolone etc.)
use of immuno-suppressive drugs
repeated use of broad-spectrum antibiotics e.g. for acne
dental mercury amalgam poisoning
other heavy metal poisoning e.g. lead, cadmium
chemical poisoning from the home, garden, workplace etc.
hormonal changes e.g. puberty, pregnancy, menopause
stress
[Edited link out]
There are many causes of candida growth. It is adversely affected by drugs (prolonged use of antibiotics promote overgrowth), vaccinations, steroids and birth-control pills; chemicals such as mercury and other toxic metals, pesticides, aspartame, MSG and perfumes; diet including sugars and refined carbohydrates, consistent alcohol consumption, nutritional deficiencies, overeating and refined, canned, smoked, preserved and fried foods.
Mercury
[Edited link out]
Mercury is an antibacterial, yet, in concentrations lower than fatal to humans, bacteria are often encouraged. Health forms of candida, normally found in the mouth, mutate under the influence of the mercury and the destructive bacteria to become harmful varieties of Candida. Mutated Candida produces at least 79 toxins. Sugar activates candida metabolism and some of its by-products are neurotoxins such as formaldehyde, alcohol and acetlyaldehyde. One's nervous system can become confused during candida infestation due to specific neurotoxins. Candida converts the element mercury to methyl mercury which is 100 times more toxic.
Mononucleosis / Glandular Fever
[Edited link out]
ozzie135
The glandular fever/candida link is often put down to the body's inability to control the bacteria in the gut when the immune system is compromised and under stress. The medical profession dismiss the fact that this can happen with a viral infection such as glandular fever because it is a relatively minor infection.
Populations More Susceptible To Candida
SCIENCE:[Edited link out]
Comparison of Candida albicans adherence to human corneocytes from various populations.
Epidemiological data indicate that patients suffering from diabetes, hypothyroidism, obesity, or following prolonged treatment with antibiotics, corticosteroids or oral contraceptives, have an increased tendency to develop cutaneous candidiasis. Since it is generally believed that attachment of microorganisms to host cells is an initial step in the evolution of infection, the aim of the present study was to investigate whether cells from susceptible individuals have increased capacity to bind the fungus. Corneocytes collected from the forearms of individuals of these susceptible groups were exposed in vitro to Candida albicans and adhesion to the cells was evaluated in comparison with adherence to cells from a non-susceptible population. Adherence in vitro was assayed microscopically and evaluated quantitatively by two parameters: 1) percentage of adherence - number of corneocytes with adhering yeasts on their surface, and 2) the total number of adhered yeasts. Results of the study revealed that the mean percentage of adherence and the mean total number of yeasts adhering to cells from individuals of the susceptible populations was twice as high as values in a healthy population. Statistical analysis of the data by Student's t-test indicated that the difference was significant (p less than 0.001).
In Short: Candida adheres twice as much to cells from individuals suffering from diabetes, hypothyroidism, obestiy, or following prolonged treatment with antibiotics, corticosteroids, or oral contraceptives.
SCIENCE:[Edited link out]
Chronic mucocutaneous candidosis associated with hypothyroidism: a distinct syndrome?
Chronic mucocutaneous candidosis (CMC) is a rare, complex disorder characterized by chronic and recurrent candida infections of the skin, nails and oropharynx. In over 50% of cases there is an associated endocrine disease, the complex being described as the candida endocrinopathy syndrome. Inheritance of familial endocrine associated cases has been thought to follow an autosomal recessive pattern. In addition, autosomal recessive and autosomal dominant forms of CMC not associated with endocrinopathy have been described. We report a new syndrome in which there is vertical transmission of CMC within families associated with primary hypothyroidism. This suggests that the candida endocrinopathy syndrome can be subdivided into at least two types, one associated with hypoparathyroidism and/or hypoadrenalism which is inherited as an autosomal recessive trait, the other associated with hypothyroidism which is an autosomal dominant disease. We emphasize the importance of early and regular monitoring thyroid function in individuals with CMC and a need to provide appropriate genetic counselling to affected members.
In Short: 50% of people who develop recurrent candida infections of the skin, nails and oropharynx have endocrine disease, including hypothyroidism.
What Candida Feeds On
[Edited link out]
The yeast, Candida Albicans, became the most popular colon microbe in the 1980's and many people still pursue yeast-free diets in an attempt to treat "candida infection" and to solve bowel symptoms. Claims that candida overgrowth in the GIT cause ill-defined illnesses are probably not true. Candida populations are balanced by competitive microbes. Colon candida are fed by milk sugar and starches in the diet which reach the colon undigested, not free sugars in food which tend to be absorbed before reaching the yeast. The presence of other kinds of yeast or fungi in the diet has little or no effect on the growth of candida in the colon. On a food holiday, the food supply to the Candida and all other colon microorganisms is reduced and the population decreases. The use of an elemental nutrient formula, even with high glucose content, is associated with reduction or disappearance of candida in the colon.
[Edited link out]
Limited effect of refined carbohydrate dietary supplementation on colonization of the gastrointestinal tract of healthy subjects by Candida albicans
Infections due to Candida albicans occur readily in situations in which ample glucose is available. In mice, dietary refined carbohydrate supplementation leads to higher rates of Candida growth in the gastrointestinal tract and favors mucosal invasion.
No correlation between C. albicans counts in the specimens and the habitual uptake of refined carbohydrates was observed. A high-sugar diet did not increase the frequency of C. albicanspositive samples, the number of subjects positive for C. albicans in the mouth washes, or the concentration of candidal blastoconidia in the samples of the 28 subjects. However, in selected subjects with elevated counts of oral C. albicans, we observed an increase in fecal C. albicans counts in response to the diet.
[Edited link out]
Candida thrives on carbohydrates, preserved refined foods and mold. Also foods that contain yeast and gluten, a wheat bread protein... Symptoms often worsen in damp and or moldy places. Also after consumption of food products rich in yeast or carbohydrate (sugars and starches) or after eating any the foods that contain mycotoxins.
Estrogens & Candida's Fungal Mode
SCIENCE:[Edited link out]
Binding and reactivity of Candida albicans estrogen binding protein with steroid and other substrates.
In this report recombinant estrogen binding protein (EBP1), isolated originally from Candida albicans as a result of its high affinity for 17beta-estradiol... It is shown that like OYE, the protein binds a variety of compounds with a phenolic structure, including 17beta-estradiol, and compounds with an alpha, beta-unsaturated keto or aldehyde structure.
[Edited link out]
Cellular and Molecular Biology of Candida albicans Estrogen Response
Candida albicans is the most common etiological agent of vaginal candidiasis. Elevated host estrogen levels and the incidence of vaginal candidiasis are positively associated. Elevated estrogen levels may affect host and/or fungal cells. This study investigates the effect of 17-s-estradiol, 17-{alpha}-estradiol, ethynyl estradiol, and estriol on several C. albicans strains at concentrations ranging from 105 to 1010 M. The addition of 17-s-estradiol or ethynyl estradiol to C. albicans cells caused an increase in the number of cells forming germ tubes and an increase in germ tube length in a dose- and strain-dependent manner. The addition of 17-{alpha}-estradiol or estriol did not have a significant effect on germ tube formation by the cultured cells. Exposure to exogenous estrogens did not significantly change the biomass of any C. albicans culture tested. The transcriptional profile of estrogen-treated C. albicans cells showed increased expression of CDR1 and CDR2 across several strain-estrogen concentration-time point combinations, suggesting that these genes are the most responsive to estrogen exposure. Analysis of strain DSY654, which lacks the CDR1 and CDR2 coding sequences, showed a significantly decreased number of germ tube-forming cells in the presence of 17-s-estradiol. PDR16 was the most highly up-regulated gene in strain DSY654 under these growth conditions. The cell biology and gene expression data from this study led to a model that proposes how components of the phospholipid and sterol metabolic pathways may interact to affect C. albicans germ tube formation and length.
In Short: Candida albicans grows more and longer germ tubes when exposed to 17-s-estradiol or ethynyl estradiol.
SCIENCE:[Edited link out]
The effect of estradiol on Candida albicans growth.
The size of colonies growing on Sabouraud's dextrose agar (SDA) supplemented with 1 microM beta estradiol (1,3,5[10]-estratiene-3,17B-diol) was compared to those growing without the estrogen supplement. Data (video pixel counts) were obtained by video capture and image analysis and revealed that yeast strains were not uniformly stimulated by estradiol. One estrogen-responsive strain was evaluated in a chemically defined medium to evaluate growth in the presence of 17-alpha and 17-beta isomers of estradiol. The beta isomer promoted more rapid growth of the test organism and resulted in greater biomass production than the alpha isomer. Understanding of the role of mammalian hormones as growth promoting signals may provide information on this organism's shift from saprophytic to commensal to pathogenic status in vivo. Strain variation in response to estrogen may provide an explanation for differences in virulence.
In Short: Some strains of candida albicans respond to beta estradiol, others do not. But importantly, this reveals terminology of the stages - saprophytic, commensal, pathogenic.
SCIENCE: [Edited link out]
Genistein effects on growth and cell cycle of Candida albicans.
Microbial virulence is generally considered to be multifactorial with infection resulting from the sum of several globally regulated virulence factors. Estrogen may serve as a signal for global virulence induction in Candida albicans. Nonsteroidal estrogens and estrogen receptor antagonists may therefore have interesting effects on yeast and their virulence factors. Growth of C. albicans was monitored by viable plate counts at timed intervals after inoculation into yeast nitrogen broth plus glucose. To determine if increased growth of yeast in the presence of estradiol was due to tyrosine kinase-mediated signaling, we measured growth in the presence of genistein, estradiol or genistein plus estradiol and compared these conditions to controls, which were not supplemented with either compound. Unexpectedly, genistein stimulated growth of C. albicans. In addition, genistein was found to increase the rate of germination (possibly reflecting release from G(0) into G(1) cell cycle phase) and also increased Hsp90 expression, demonstrated by a dot blot technique which employed a commercial primary antibody detected with chemiluminescence with horseradish peroxidase-labeled secondary antibody. These biological effects may be attributable to genistein's activity as a phytoestrogen. In contrast, nafoxidine suppressed growth of Candida and mildly diminished Hsp90 expression. This study raises the possibility of receptor cross-talk between estrogen and isoflavinoid compounds, and antiestrogens which may affect the same signaling system, though separate targets for each compound were not ruled out.
In Short: LOOK AT THIS! Genistein stimulates growth of Candida albicans and increases the rate of germination. As a phytoestrogen (isoflavone) it's an activator of candida albicans! And those with Gilbert's have trouble processing estrogens, making an environment that encourages candida albucans growth. Also, investigate nafoxidine as a possible way to regulate this environment.
Part 2 coming later. Wont let me post anymore atm.
^Thanks. We needed a page long about candida.
Has anyone else noticed every time people actually start communicating, he suddenly comes in and posts a copy paste about gut flora or some bacterial overgrowth. I mean Every day?
5 hours ago, cnb30 said:I like how the main reason my doctors tell me not to kill myself (that everyone who is depressed eventually improves) is no longer valid.
Until you've exhausted all options in treating your depression you really shouldn't just give up like that. I've posted a few links of new innovative ways they are using hyperbaric oxygen therapy and ketamine (google: depression, hb0t). Also, there is scientific evidence that some SSRI's have regenerating capabilities in regards to plasticity of the brain. I obviously wouldn't advise straight into the pharmaceutical route to treat your depression, as we know its a slippery slope, but it is an option. Removing yourself from the equation actually helps whoever did this to you and makes the world that much worse off without you. So, maybe you can't convince the thousands of know it all willful ignorant masses online, but say you have a conversation with 20-30 people in your personal life, about your experience, and those 20 people end up being in that same scenario or end up having kids in that scenario where they are offered a pill, they end up researching before taking, and ultimately decide it's not worth the risk all because of your precautionary warning. The universe has a funny way of balancing out in the end. It's worth it to just sit back and watch it play out.
9 hours ago, cnb30 said:Have any of you guysreallyseen any true benefits from supplements, pro-biotic a, etc, or is this just part of an endless quest and more of a placebo thing?
Even if that would be placebo then what's wrong with that? Mind is pretty powerful and can help or damage healing process. Although frankly probiotics didn't helped me. From some time I'm making my own kefir and maybe that will help me more? I've tried making kefir with tibetan mushroom but end result was weird, besides I bought it onine and get in a package - who knows how many bad bacteria it had on itself? So now, I a using capsules from drugstore and kefir is really good, it even taste very good.
In terms of bloatness what helped me is yoga. I was sceptic but after years of suffering I wanted to tried everywthing. Acupuncture did nothing to me, although I saw huge improvements in many people. The best improvements I saw was from leeches but I couldn't had them because of my liver. I mean those leeches were like magic. People had faith in guy doing this (acupunture/leeches) because he was a real doctor(and gratuaded not from some shitty university but in Moscow) so it wasn't some charlatan.
You can print 10 pages of candida info - ok lets believe we have a problem with it. What next though? - I've tried anti candida products before but with no noticeable effect. Plus take the worst cases of accutane issues i.e having to have part of the bowel removed - do you really think these people were worried about combating candida!!?
Somehow I think the drug has done more damage beyond affecting gut health.....wouldn't you agree!?
Hello
my next input. For the record I suffer from zero libido and poor erections.
My last post showed my intestinal dysbiosis.
Now it looks like I have candida. Blood test shows candida antibodies - norm 0-5, I score 7.5. Apparently it's not very bad and I'm exptected to treat it with probiotics only...
But I did catocholamins 24h urine test (picture attached)
As you can see - terrible results, Any ideas where does it take me next?
I have some moderately good news for everyone, which is that my libido appears to be recovering over the past month, albeit very VERY slowly.
2 hours ago, pabpab said:Hello
my next input. For the record I suffer from zero libido and poor erections.
My last post showed my intestinal dysbiosis.
Now it looks like I have candida. Blood test shows candida antibodies - norm 0-5, I score 7.5. Apparently it's not very bad and I'm exptected to treat it with probiotics only...But I did catocholamins 24h urine test (picture attached)
As you can see - terrible results, Any ideas where does it take me next?
By the way check if you have SIBO, it doesn't cost much and it's non-invasive. I've done my test in Poznan hospital(Jonschera)
You guys complain about him, but guitarman01 is probably right. About 3 months after taking accutane, I started having episodes about once a month where my throat would almost close up.
The 1st time at doctors they diagnosed me with strep even though the test came back negative. 2nd time they said I had mono even though test was negative. Weird thing then was my doctor said my t cell count was low when usually it's high with mono. These episodes kept happening until I finally just got my tonsils out last summer.
Unfortunately this didn't solve anything of course (just changed how my body tolerated it). I still get sore throats, but now there's no tonsils to swell up and block my throat. My sexual side effects have also gotten worse since this happened. I'm guessing without the tonsils to block some of the bad bacteria, it's all getting into my system.
17 hours ago, ACCUiTy_drANE said:The chronic brain fog, anhedonia, and slower mental processing are what impact me most. I have improved my cognitive fluency through practice. But that is simply me adapting. Granted, I DO have days that I feel decent days mentally, but I'm yet to see reliable progress mentally.
Hi, can I ask, what sort of practice do you feel has improved your cognitive fluency?
2 hours ago, Umas said:By the way check if you have SIBO, it doesn't cost much and it's non-invasive. I've done my test in Poznan hospital(Jonschera)
Czesc
I haven't yet.
What sort of sides are you struggling to recover from?
On 26.07.2016 at 1:01 AM, Iamme. said:Yes it sucks but being dead isn't great either.
Try a PMO reboot for Atleast 6 months. Perhaps take some dl-phenylalanine and egcg as I beleive it can rebuild dopamine pathways. That should get your libido back. But it has to be a commitment.And yeah i recovered my libido and ed. As for personality, that can come back with increased vitality, gym can help. I'm on a nutrional balancing program and that's helped.
Mate, can you elaborate on this a little more?
Personally I'd say I recovered from everything but still have ZERO libido.
A few years back I did a PMO reboot (100 days which improved my erections yet libido was still non-existent.
Now I made a commitment I'm not going to have sex or maturbate (and I have a hot gf) unless I sort out my libido. So as far as we are talking commitnemnt I can do anything for a year or two if it means my libido is normal again.
2 hours ago, pabpab said:CzescI haven't yet.
What sort of sides are you struggling to recover from?
Mate, can you elaborate on this a little more?
Personally I'd say I recovered from everything but still have ZERO libido.A few years back I did a PMO reboot (100 days which improved my erections yet libido was still non-existent.
Now I made a commitment I'm not going to have sex or maturbate (and I have a hot gf) unless I sort out my libido. So as far as we are talking commitnemnt I can do anything for a year or two if it means my libido is normal again.
Yeah I did about 180 days in total. That brought back my libido. However libido wasn't the worst for me out of my symptoms.