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1 minute ago, QuietSoldier said:18 minutes ago, snarkygirl said:http://www.huffingtonpost.com/alexander-m-spring/accutane-putting-your-per_b_1314233.html
http://max001.proboards.com/board/15/section-affected-neurotransmitters-parts-brain
heres some links on it...basically accutane kills serotonin and inhibits dopamine in many people.Thank you. So would ridding the body of leftover tane fix this problem? Or has the drug changed our DNA?
I know most people who show depression while on it recover in about 6 months, my boyfriend was similar. The problem seems to be when people get depression after ending it...it seems to last longer if it shows up later. Idk if it changes our DNA but anything that would raise dopamine and serotonin would be good.
On 7/11/2016 at 2:36 PM, QuietSoldier said:Day 3 of taking one pill (450mg) of saw palmetto per day. Penis is responding much better to visual stimului than before. Still not like it used to, bit much better. Bloodflow during erections seems better as well. The glans especially is filling up with more blood than previously.
On a side note, I read that cannabis is a DHT-Inhibitor also. Could be why some people see improvements using that Avenue (along with the increased dopamine of course). Also heard that antibiotics increase AR expression. I remember seeing some people cured themselves using two specific antibiotics, so maybe that's why they saw some healing.
Hi Soldier. Just wondered if you have continued the saw palmetto treatment and still seeing benefits?
Theory on why RSO and weed make people feelbetter with its THC content? This also goes back to that youtube video on how to get rid of the accutane metabolites.Accutane conjugates with glucuronic acid to leave the body. accutane depletes glucuronic acid causing accumulated GCA substrates that get recycled .
RSO and weed contain THC, which increases GCA activity causing the plasma levels of the glucuronidated drug (accutane) to fall and be excreted.
the very last paragraph explains whycalcium d glucarate is also mentioned in that youtube video. its used to inhibit
the-glucuronidase
anyone with high bilirubin would be a marker for this. If you had Gilbert syndrome before accutane... u basically cant get rid of it.
Metabolism and Elimination of 9-THC
9-THC is metabolized in the liver by microsomal hydroxylation and oxidation catalyzed by enzymes of cytochrome P450 (CYP) complex. The average plasma clearance rates have been reported to be 11.8 3 L/hour for women and 14.9 3.7 L/hour for men (59). Others have determined approximately 36 L/hour for naive cannabis users and 60 L/hour for regular cannabis users12.
More than 65% of cannabis is excreted in the feces and approximately 20% is excreted in urine (58).Most of the cannabis (80-90%) is excreted within 5 days as hydroxylated and carboxylated metabolites (67). There are eighteen acidic metabolites of cannabis identified in urine (68) and most of these metabolites form a conjugate with glucuronic acid, which increases its water solubility. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570572/
Bilirubinis excreted in the bile asbilirubin diglucuronide(80%),bilirubin monoglucuronide(20%), and unconjugated bilirubin (< 1%). In theCrigler-Najjar syndromeand theGilbert syndrome, UDPGT activity is reduced or nearly absent due to mutations, resulting injaundice.
It is possible to exhaust the bodies supply of glucuronic acid by combining multiple drugs/substances whose metabolism and excretion are primarily or entirely dependent on glucuronidation. Although most such substances have secondary metabolic routes which become prominent following GCA depletion, the rate of metabolism is reduced enough to produce a marked accumulation of all GCA substrates in the system; this often increases drug concentrations in the blood by medically relevant amounts. In the most severe cases permanent and debilitating organ damage (particularly the liver, kidneys, heart, and brain), and even death, have been known to occur.Ethanol,morphinones,acetominophen, cooxygenase inhibitors (NSAIDs),endogenoussteroids, and certainbenzodiazepinesare all capable of contributing to GCA depletion, with ethanol and acetominophen being the most commonly implicated substances involved in cases of accidental overdoses which have been positively attributed to glucuronic acid depletion.
Excessive quantities of GCA can also be hazardous to health, tobacco smoke, mostbarbiturates, and some carbamates are known to actually stimulate GCA production. Increased GCA activity results in a decrease of the concentration and metabolic half-life of glucuronic acid substrates, causing the plasma levels of glucuronidated drugs to fall below their therapeutic threshold. Excessive glucuronidation of the substrates may result in an inadequate response to traditional doses of affected medications and, unless the drug has a very wide therapeutic index, will generally result in the acute failure of the pharmacotherapy and necessitate the transition of one or more implicated drugs to an equivalent regimen of non-glucuronidated alternatives. A select number of antidepressants and a wide range of anti-psychotic agents are glucuronidation ligands but due to their delayed mechanism of action and pharmacokinetic properties the decrease of their plasma concentrations may not be immediately apparent and tends to present as a sudden and intense relapse of symptoms instead of a gradual regression to the behaviors and thought patterns exhibited by the patient prior to the initiation of their pharmacological treatment.
Glucuronides may behydrolyzedby-glucuronidasepresent in intestinal microflora to the respective aglycone, which may be reabsorbed from the intestine and translocated back to the liver with the blood. The resulting cycle is calledenterohepatic circulation. Compounds that undergo enterohepatic circulation are only slowly excreted and usually have a longer half-life in the body. https://en.wikipedia.org/wiki/Glucuronic_acid
..........
Hey Guys, I just wanted to make my experience heard. It's kinda a personal account, but I think some of the details need to be told in order for more of an understanding of how I got to here today. (Plus I realize I sound like a very crazy person at times, but I'm just trying to get out so much of what I've been going through onto here).
Before accutane, I was already incredibly upset, and felt like all my Ideals, hopes, and dreams were falling apart on me, plus I was never content in highschool and had been hoping for years to get out of suburbia and into a city I actually gave a damn about and study architecture (my passion since I was little). I had huge insecurities about being one of the last of my friends to ever get laid, plus I was having trouble getting over an ex I had been obsessed with (like I couldn't stop thinking about her 24/7), and I realize that I became pretty bitter over at least a half dozen other things by the beginning of senior year, which led to depression and loneliness by the winter (I also had a favorite teacher from the year before pass away and had experienced some disturbing dreams related to him dying the night before I found out). Needless to say, by the time I started taking accutane, I had too much on my mind to really know what was going on. Honestly, the only reason why I remember agreeing to take accutane was because my confidence had dropped to about a zero mid way through senior year (after being incredibly high about 2 years ago even when I still HAD acne).
Anyway, my doctor told me not to worry about the side effects and that they all go away after treatment and that everybody went back to feeling normal. I was incredibly desperate so I just went with it, and didn't care about the depression part because screw it, I was already depressed. Anyway, at first, I remember slowly feeling headaches and drying of lips, the usual stuff, until about 3-4 weeks in I noticed I stopped caring about things. Looking back, I never made the connection that this was depression, and just accepted it as relief from what I had been going through, and of course continued with the medication under the guise that A) I was finally feeling relieved B. My already terrible senioritis was getting worse, and C) I would be back to feeling like Me after all this was done. I BSed my way through the rest of the year and went off the accutane a couple weeks before graduation thinking that maybe I'll be able to feel something and care again by graduation (by the way, I had another teacher pass away in mid March suddenly, and felt like I didn't care, but didn't even think anything about the medicine).
Anyway, I feel like a number of things hit me the last 2 weeks of school and first week of summer. First, other than the dryness clearing up, none of the other side effects disappeared and I still felt completely anhedonic. Second, graduation , the event I had been counting down to for 4 years was pretty much bleh (even though I won a huge scholarship). Third- I ran into my ex for the first time in months (she was at college out of state) and felt absolutely NOTHING (compare that with how I felt like I had a mini emotional heart attack when I ran into a month before accutane), not even a vague sexual attraction of any kind. Also, I realized that my favorite songs no longer gave me the nostalgic feelings they used to.
After coming back hungover from beach week (this was a few weeks after pausing accutane as I was planning to do 1 more month) , and realizing that I miraculously seemed to have lost my libido, ability to feel, and ability to care. I am no longer able to feel anything whatsoever: happy, sad, horny, scared, in love, you name it. Basically all I can feel is satisfaction from sleeping, and a desire to just cease to exist. I've seen multiple doctors and they simply deny everything that I've told them about how I've changed on accutane, and in fact one (who I now despise) was rudely blunt telling me to "get over it". Now, over 2 months after finishing, I realize ALOT
-The drug has permanently damaged my head (after all, it's supposed to do permanent things to you)
-I will likely no longer be the same caring driven person I once was
-I can see why most people who take the drug think they're happier because they probably care less about things (after all, ignorance is bliss)
-The reasons why I went on this drug Ironically no longer matter, as I am neither sexually, nor romantically interested in ANYONE, and couldn't care less if they were interested in me, I'm incapable of feelings.
-The very people who are supposed to be helping me wont even acknowledge the problem exists
-I've gone through so many changes of mind that I think I'm realizing that we're all nothing more than a bunch of chemicals and electrical impulses and that life is in fact meaningless (I used to be a VERY principled person)
-The more I've looked into it, I realize that I've pretty much fallen for the stereotypical movie plot with a wonder product that has a dark secret of some kind (in this case, it destroys who you are, yet the company is able to take advantage of weak human psyche, and the long time it takes for the drug to slowly work its dark magic, to keep making tons of money).
Lastly, to conclude, next year, I'm going to study the major of my dreams (Architecture), in the city of my dreams (NYC, trust me, I've spent hours obsessing over NYC) at the school of my dreams and I don't care one bit about any of it. I was there a few days ago, and looking at the skyline was no different that looking at a field in Kansas. Hell I was satisfied seeing all the cool buildings, and savoring all of the delicious food, but I felt no excitement whatsoever, and no inspiration. I used to be a driven passionate person, and I've finally made it to the place that has inspired me for so long, and I don't even give a rats ass over anything I cared about anymore.
PS I've you've read the entire thing and don't think I sound nuts, you deserve one hell of a medal.
1 hour ago, cnb30 said:Hey Guys, I just wanted to make my experience heard. It's kinda a personal account, but I think some of the details need to be told in order for more of an understanding of how I got to here today. (Plus I realize I sound like a very crazy person at times, but I'm just trying to get out so much of what I've been going through onto here).
Before accutane, I was already incredibly upset, and felt like all my Ideals, hopes, and dreams were falling apart on me, plus I was never content in highschool and had been hoping for years to get out of suburbia and into a city I actually gave a damn about and study architecture (my passion since I was little). I had huge insecurities about being one of the last of my friends to ever get laid, plus I was having trouble getting over an ex I had been obsessed with (like I couldn't stop thinking about her 24/7), and I realize that I became pretty bitter over at least a half dozen other things by the beginning of senior year, which led to depression and loneliness by the winter (I also had a favorite teacher from the year before pass away and had experienced some disturbing dreams related to him dying the night before I found out). Needless to say, by the time I started taking accutane, I had too much on my mind to really know what was going on. Honestly, the only reason why I remember agreeing to take accutane was because my confidence had dropped to about a zero mid way through senior year (after being incredibly high about 2 years ago even when I still HAD acne).
Anyway, my doctor told me not to worry about the side effects and that they all go away after treatment and that everybody went back to feeling normal. I was incredibly desperate so I just went with it, and didn't care about the depression part because screw it, I was already depressed. Anyway, at first, I remember slowly feeling headaches and drying of lips, the usual stuff, until about 3-4 weeks in I noticed I stopped caring about things. Looking back, I never made the connection that this was depression, and just accepted it as relief from what I had been going through, and of course continued with the medication under the guise that A) I was finally feeling relieved B. My already terrible senioritis was getting worse, and C) I would be back to feeling like Me after all this was done. I BSed my way through the rest of the year and went off the accutane a couple weeks before graduation thinking that maybe I'll be able to feel something and care again by graduation (by the way, I had another teacher pass away in mid March suddenly, and felt like I didn't care, but didn't even think anything about the medicine).
Anyway, I feel like a number of things hit me the last 2 weeks of school and first week of summer. First, other than the dryness clearing up, none of the other side effects disappeared and I still felt completely anhedonic. Second, graduation , the event I had been counting down to for 4 years was pretty much bleh (even though I won a huge scholarship). Third- I ran into my ex for the first time in months (she was at college out of state) and felt absolutely NOTHING (compare that with how I felt like I had a mini emotional heart attack when I ran into a month before accutane), not even a vague sexual attraction of any kind. Also, I realized that my favorite songs no longer gave me the nostalgic feelings they used to.
After coming back hungover from beach week (this was a few weeks after pausing accutane as I was planning to do 1 more month) , and realizing that I miraculously seemed to have lost my libido, ability to feel, and ability to care. I am no longer able to feel anything whatsoever: happy, sad, horny, scared, in love, you name it. Basically all I can feel is satisfaction from sleeping, and a desire to just cease to exist. I've seen multiple doctors and they simply deny everything that I've told them about how I've changed on accutane, and in fact one (who I now despise) was rudely blunt telling me to "get over it". Now, over 2 months after finishing, I realize ALOT
-The drug has permanently damaged my head (after all, it's supposed to do permanent things to you)
-I will likely no longer be the same caring driven person I once was
-I can see why most people who take the drug think they're happier because they probably care less about things (after all, ignorance is bliss)
-The reasons why I went on this drug Ironically no longer matter, as I am neither sexually, nor romantically interested in ANYONE, and couldn't care less if they were interested in me, I'm incapable of feelings.
-The very people who are supposed to be helping me wont even acknowledge the problem exists
-I've gone through so many changes of mind that I think I'm realizing that we're all nothing more than a bunch of chemicals and electrical impulses and that life is in fact meaningless (I used to be a VERY principled person)
-The more I've looked into it, I realize that I've pretty much fallen for the stereotypical movie plot with a wonder product that has a dark secret of some kind (in this case, it destroys who you are, yet the company is able to take advantage of weak human psyche, and the long time it takes for the drug to slowly work its dark magic, to keep making tons of money).Lastly, to conclude, next year, I'm going to study the major of my dreams (Architecture), in the city of my dreams (NYC, trust me, I've spent hours obsessing over NYC) at the school of my dreams and I don't care one bit about any of it. I was there a few days ago, and looking at the skyline was no different that looking at a field in Kansas. Hell I was satisfied seeing all the cool buildings, and savoring all of the delicious food, but I felt no excitement whatsoever, and no inspiration. I used to be a driven passionate person, and I've finally made it to the place that has inspired me for so long, and I don't even give a rats ass over anything I cared about anymore.
PS I've you've read the entire thing and don't think I sound nuts, you deserve one hell of a medal.
Cool story
10 hours ago, cnb30 said:Hey Guys, I just wanted to make my experience heard. It's kinda a personal account, but I think some of the details need to be told in order for more of an understanding of how I got to here today. (Plus I realize I sound like a very crazy person at times, but I'm just trying to get out so much of what I've been going through onto here).
Before accutane, I was already incredibly upset, and felt like all my Ideals, hopes, and dreams were falling apart on me, plus I was never content in highschool and had been hoping for years to get out of suburbia and into a city I actually gave a damn about and study architecture (my passion since I was little). I had huge insecurities about being one of the last of my friends to ever get laid, plus I was having trouble getting over an ex I had been obsessed with (like I couldn't stop thinking about her 24/7), and I realize that I became pretty bitter over at least a half dozen other things by the beginning of senior year, which led to depression and loneliness by the winter (I also had a favorite teacher from the year before pass away and had experienced some disturbing dreams related to him dying the night before I found out). Needless to say, by the time I started taking accutane, I had too much on my mind to really know what was going on. Honestly, the only reason why I remember agreeing to take accutane was because my confidence had dropped to about a zero mid way through senior year (after being incredibly high about 2 years ago even when I still HAD acne).
Anyway, my doctor told me not to worry about the side effects and that they all go away after treatment and that everybody went back to feeling normal. I was incredibly desperate so I just went with it, and didn't care about the depression part because screw it, I was already depressed. Anyway, at first, I remember slowly feeling headaches and drying of lips, the usual stuff, until about 3-4 weeks in I noticed I stopped caring about things. Looking back, I never made the connection that this was depression, and just accepted it as relief from what I had been going through, and of course continued with the medication under the guise that A) I was finally feeling relieved B. My already terrible senioritis was getting worse, and C) I would be back to feeling like Me after all this was done. I BSed my way through the rest of the year and went off the accutane a couple weeks before graduation thinking that maybe I'll be able to feel something and care again by graduation (by the way, I had another teacher pass away in mid March suddenly, and felt like I didn't care, but didn't even think anything about the medicine).
Anyway, I feel like a number of things hit me the last 2 weeks of school and first week of summer. First, other than the dryness clearing up, none of the other side effects disappeared and I still felt completely anhedonic. Second, graduation , the event I had been counting down to for 4 years was pretty much bleh (even though I won a huge scholarship). Third- I ran into my ex for the first time in months (she was at college out of state) and felt absolutely NOTHING (compare that with how I felt like I had a mini emotional heart attack when I ran into a month before accutane), not even a vague sexual attraction of any kind. Also, I realized that my favorite songs no longer gave me the nostalgic feelings they used to.
After coming back hungover from beach week (this was a few weeks after pausing accutane as I was planning to do 1 more month) , and realizing that I miraculously seemed to have lost my libido, ability to feel, and ability to care. I am no longer able to feel anything whatsoever: happy, sad, horny, scared, in love, you name it. Basically all I can feel is satisfaction from sleeping, and a desire to just cease to exist. I've seen multiple doctors and they simply deny everything that I've told them about how I've changed on accutane, and in fact one (who I now despise) was rudely blunt telling me to "get over it". Now, over 2 months after finishing, I realize ALOT
-The drug has permanently damaged my head (after all, it's supposed to do permanent things to you)
-I will likely no longer be the same caring driven person I once was
-I can see why most people who take the drug think they're happier because they probably care less about things (after all, ignorance is bliss)
-The reasons why I went on this drug Ironically no longer matter, as I am neither sexually, nor romantically interested in ANYONE, and couldn't care less if they were interested in me, I'm incapable of feelings.
-The very people who are supposed to be helping me wont even acknowledge the problem exists
-I've gone through so many changes of mind that I think I'm realizing that we're all nothing more than a bunch of chemicals and electrical impulses and that life is in fact meaningless (I used to be a VERY principled person)
-The more I've looked into it, I realize that I've pretty much fallen for the stereotypical movie plot with a wonder product that has a dark secret of some kind (in this case, it destroys who you are, yet the company is able to take advantage of weak human psyche, and the long time it takes for the drug to slowly work its dark magic, to keep making tons of money).Lastly, to conclude, next year, I'm going to study the major of my dreams (Architecture), in the city of my dreams (NYC, trust me, I've spent hours obsessing over NYC) at the school of my dreams and I don't care one bit about any of it. I was there a few days ago, and looking at the skyline was no different that looking at a field in Kansas. Hell I was satisfied seeing all the cool buildings, and savoring all of the delicious food, but I felt no excitement whatsoever, and no inspiration. I used to be a driven passionate person, and I've finally made it to the place that has inspired me for so long, and I don't even give a rats ass over anything I cared about anymore.
PS I've you've read the entire thing and don't think I sound nuts, you deserve one hell of a medal.
Hi. No, youre not nuts. My boyfriend had the same thing happen to him. He was sort of depressed over a break up with a girl who'd had an abortion ( maybe his kid, he wasn't told until after) and he was just really down in general. He only took accutane 20mg for 1 month and had a suicide attempt It took him 6 months to sort of recover, and by recover I mean not be suicidal. He said everything felt dark and bleak like there was no hope or point. That was years ago, he's OK mentally but he has IBS and joint issues still.
The anti smoking drug Chantix had similar results, I know a guy who hanged himself without a history of depression.
Both drugs kill your serotonin production and disrupt your dopamine receptors. Since both chemicals= feelings of happy and reward, no wonder you feel devoid of anythinggood.
My advice is to focus on repairing your gut and finding ways to increase serotonin and dopamine. Your serotonin is made in the gut so many instances of accutane causing gut issues may be related.
There are antidepressants which work on those chemicals but be careful, many might make you more suicidal IN THE FIRST6 WEEKS or be addicting. I'm not saying g you shouldn't take an antidepressant but you should be cautious. Hell even marijuana might be a good idea.
I'm sorry you are dealing with this but its not that you're nuts or weak. A drug had bad side effects on you and honestly, you guys on this thread should all sue Roche. These drug companies dont give a flying fuck what happens tp people unless they are forced to pay out.That would give me a lot of satisfaction.
21 minutes ago, snarkygirl said:Hi. No, youre not nuts. My boyfriend had the same thing happen to him. He was sort of depressed over a break up with a girl who'd had an abortion ( maybe his kid, he wasn't told until after) and he was just really down in general. He only took accutane 20mg for 1 month and had a suicide attempt It took him 6 months to sort of recover, and by recover I mean not be suicidal. He said everything felt dark and bleak like there was no hope or point. That was years ago, he's OK mentally but he has IBS and joint issues still.
The anti smoking drug Chantix had similar results, I know a guy who hanged himself without a history of depression.
Both drugs kill your serotonin production and disrupt your dopamine receptors. Since both chemicals= feelings of happy and reward, no wonder you feel devoid of anythinggood.
My advice is to focus on repairing your gut and finding ways to increase serotonin and dopamine. Your serotonin is made in the gut so many instances of accutane causing gut issues may be related.
There are antidepressants which work on those chemicals but be careful, many might make you more suicidal IN THE FIRST6 WEEKS or be addicting. I'm not saying g you shouldn't take an antidepressant but you should be cautious. Hell even marijuana might be a good idea.
I'm sorry you are dealing with this but its not that you're nuts or weak. A drug had bad side effects on you and honestly, you guys on this thread should all sue Roche. These drug companies dont give a flying fuck what happens tp people unless they are forced to pay out.That would give me a lot of satisfaction.
Yeah not gonna lie, I've been feeling suicidal a lot, but that I need to take down Roche first tho (or in my case Teva Generics). Hell Im at a point where I'm close to cutting myself.
On 21.07.2016 at 11:25 PM, tryingtohelp2014 said:your heavy sweating.... did it mainly start on your forehead.. and then the rest of body... like sweating thru your shirt? that could be the Vit D.
No, my heavy sweating starts extremely on my feets, hands and armpits. It always comes together with hot flushes.
Have you ever asked yourself why do you have a deficiency of Vitamin d and bio-active copper?
9 hours ago, Iamme. said:Cool story
Dosage?
25 minutes ago, cnb30 said:Yeah not gonna lie, I've been feeling suicidal a lot, but that I need to take down Roche first tho (or in my case Teva Generics). Hell Im at a point where I'm close to cutting myself.
Smoke pot , it's not that bad . If I get depressed about tan I get drunk works for me. I have learned to accept my side effects.
2 hours ago, cnb30 said:Yeah not gonna lie, I've been feeling suicidal a lot, but that I need to take down Roche first tho (or in my case Teva Generics). Hell Im at a point where I'm close to cutting myself.
try hypnosis maybe? I mean if you can afford it it can't hurt.
Have you tried pot? In some states its even legal for medical issues...though I think it should be legal anyway. I personally think edibles or some sort of oil is best since smoking isn't good for your general health...but smoking once or twice a week isn't that bad.
4 hours ago, Gladiatoro said:Dosage? Smoke pot , it's not that bad . If I get depressed about tan I get drunk works for me. I have learned to accept my side effects.
My dosage was 80 mg per day. honestly tho, I don't think I have the will to live if I am unable to feel hopes dreams etc. I'm not spending 60 years of my life a depressed pothead or drunk. Honestly I'm tempted to just end it all if I fail out of Architecture school. (Of course I'll get revenge first)
Putting the fear of death into them is probably the only thing that would have an impact at this point. The pharmaceutical companies are untouchable by the letter of the law. Anyone who had their hands in doing this to us deserves to die.
Summary:Accutane is dangerous but it works. My experience caused me to withdraw from it in the middle of treatment and since then I haven't turned back.
I don't believe Accutane is bad; it's just a dangerous drug. It's a god sent for people and has cured many people of devastating social lives, professional lives, and has helped millions of people. The thing is, this drug has been renowned to be dangerous and has gotten so many restrictions placed upon it. The original company that manufactured it went out of business due to the lawsuits associated with the side effects.
All the Accutane drugs you see on the market are generic. They're not from the original manufacturer because of the side effects. I read that a child of one of the U.S. senators died from suicide associated with the drug's usage which led to an investigation. So yes, the drug is dangerous. It's your responsibility if you're taking a drug, even if it's been prescribed by a doctor, to look into its side effects to prevent long-term side effects. That's why they have side effect labels available for customer viewing.
My experience: When I took Accutane for 2 months at 60mg/d, it pushed my already depressive behavior into overdrive. I couldn't smile, laugh, or even see the joy of life. I wanted to suicide and my joints felt like a 100 year old man. I couldn't walk up stairs due to the joint pain. I got off the drug immediately and never returned to a dermatologist office since. Was it anecdotal? Definitely not since I enjoy life now since I've been off the drug for a year and my joints are back to normal.
But it's a lesson to all of you that Accutane is dangerous and requires advanced medical supervision along with you monitoring your body. If you can't do that then might as well swallow poison and hope it doesn't kill you. Sorry if that's harsh but that's a really good analogy of how dangerous Accutane is, but it works.So does natural methods as well and that's why we're here - to see what really works for us.
AcneScience, that is totally incorrect about the manufacturer going out of business.
They made tens, or possibly hundreds, of billions on the drug and only lost tens of millions in lawsuits. They changed their company name to Genentech in the US and their US patent simply expired, so they discontinued Accutane in the US under pressure from generics sales (whose manufacturers are not liable under US law). It is still sold in Europe under the name roaccutane. They ruined our lives and got away with it.
And the side effect warnings can get shoved up the dermatologists asses for all it matters. The list of adverse events associated with Accutane is incomplete and does not warn of the permanency of the damage done. Many dermatologists will flat-out deny certain side effects are possible and give you the swift kick out of their office. They are tools with prescription pads.
Ps: Patients are absolutely not entitled to make a decision based on side effect warnings. This is the doctor's job. Total gray area, but don't place the blame on us.
Q: How do you stump a dermatologist?
A: Ask them how Accutane works.
They will either tell you its mechanism of action is not understood, or they will make up some bullshit that sounds plausible in their minds and to the ears of a common patient. All of the ill effects of Accutane simply cannot be measured in blood tests.
1 hour ago, cnb30 said:5 hours ago, Gladiatoro said:Dosage? Smoke pot , it's not that bad . If I get depressed about tan I get drunk works for me. I have learned to accept my side effects.My dosage was 80 mg per day. honestly tho, I don't think I have the will to live if I am unable to feel hopes dreams etc. I'm not spending 60 years of my life a depressed pothead or drunk. Honestly I'm tempted to just end it all if I fail out of Architecture school. (Of course I'll get revenge first)
Holy crap thats high. This is why I get so Effing mad, seems have no business prescribing 80 mg of this stuff to anybody. 40 mg is the honest dosage anybody should have, safely.
Ive also been suicidal ( it runs in my family Ive had like 4 uncles off themselves) but honestly, I'm glad I'm here. You might need to get on some meds bor detox or pursue a vendetta ( hey vengeance is worth living for). I'm honestly glad I didn't kill myself a few years ago, my life I'd pretty good right now. At the time I thought I would be better off dead even plotted how to do it. But the world needs another architect or at least a person who is able to fight for their beliefs.
Message me or one of the mods if you need help. I know what its like to be numb and want it to end. But I also know it is possible to come out of it.
14 minutes ago, Dubya_B said:AcneScience, that is totally incorrect about the manufacturer going out of business.
They made tens, or possibly hundreds, of billions on the drug and only lost tens of millions in lawsuits. They changed their company name to Genentech in the US and their US patent simply expired, so they discontinued Accutane in the US under pressure from generics sales (whose manufacturers are not liable under US law). It is still sold in Europe under the name roaccutane. They ruined our lives and got away with it.
And the side effect warnings can get shoved up the dermatologists asses for all it matters. They do not warn of the permanency of the damage done. Many will flat-out deny certain side effects are possible and give you the swift kick out of their office. They are tools with prescription pads, not scientists.
Ask a dermatologist how Accutane works. They will either tell you its mechanism of action is not understood, or they will make up some bullshit that sounds plausible in their minds and to the ears of a common patient.
hmm that's a shame ( that they didn't go bankrupt).
I think it does work in some cases, mostly in cases where the person would have grown out of their acne anyway...it just kind of speeds things along. But too many people are on TOO HIGH a dosage and are not being properly supervised and made aware of potential problems by the doctors prescribing it.
As fat as how accutane works, it kills the oil glands for a while, correct? I'm not sure exactly how but toxicity may play a role.
I have my ups and downs but life is always worth living it's precious find a hobby you like or a girlfriend find a cause to fight for there are people in wheelchairs that are still happy think about that.
2 minutes ago, Gladiatoro said:I have my ups and downs but life is always worth living it's precious find a hobby you like or a girlfriend find a cause to fight for there are people in wheelchairs that are still happy think about that.
You can't keep a girlfriend if Accutane destroyed your sexual ability and you can't enjoy hobbies when the part of your mind that produces sensations of pleasure has been destroyed.
Yeah I agree the sexual disfunction must suck , somehow I didn't get that I guess I'm very lucky but people have had way worse things happen to them than tan , my allopathic doctor told me it's not that bad and that I have to watch my diet and take better care of myself and he is right.
2 hours ago, Dubya_B said:You can't keep a girlfriend if Accutane destroyed your sexual ability and you can't enjoy hobbies when the part of your mind that produces sensations of pleasure has been destroyed.
thats true...but dont give up, there is an answer out there.
21 hours ago, cnb30 said:-The drug has permanently damaged my head (after all, it's supposed to do permanent things to you)
-I will likely no longer be the same caring driven person I once was
-I can see why most people who take the drug think they're happier because they probably care less about things (after all, ignorance is bliss)
-The reasons why I went on this drug Ironically no longer matter, as I am neither sexually, nor romantically interested in ANYONE, and couldn't care less if they were interested in me, I'm incapable of feelings.
-The very people who are supposed to be helping me wont even acknowledge the problem exists
-I've gone through so many changes of mind that I think I'm realizing that we're all nothing more than a bunch of chemicals and electrical impulses and that life is in fact meaningless (I used to be a VERY principled person)
-The more I've looked into it, I realize that I've pretty much fallen for the stereotypical movie plot with a wonder product that has a dark secret of some kind (in this case, it destroys who you are, yet the company is able to take advantage of weak human psyche, and the long time it takes for the drug to slowly work its dark magic, to keep making tons of money).
Gosh, all this talk about anhedonia is really hitting home. Yes, this drug seemed to zap me of my ability to feel any passion or drive. Sometimes I am not sure if it's a PHYSICAL feeling (i.e., fog) preventing me from feeling pleasure, or as if all of my emotions have simply been blunted. It's like I lost the ability to conceptualize any of my feelings or emotions. I never know if I am angry, happy, or irritable, etc. Everything is shallow and fleeting.There seems to be no overarching meaning to my emotions. It really makes me second guess every facet of my life direction.
I have had depression issues before Accutane, but they were in the realm of intense feelings of sadness. My contemporary problems are of a distinctively different brand. In fact, it has shifted how I view life too. Prior to Accutane, I never understood the appeal of drugs. It was because I could enjoy hobbies and simple activities. Now a days, I have no idea what to do with myself when I have time to myself. Video games aren't fun. I can't get hooked on a book. I can't get lost in an idea. I can't fantasize in my head the way I used to. Everything is dull. Now a days, I know what it's like to crave an artificial escape. My proclivity for risk-taking has sky-rocketed. My everyday "neurotransmitter noise" is vastly different than it once was. It makes me wonder what other people feel day-to-day; it makes me wonder what other spectrums people possess. Some people are hyper-motivated overachievers. Some are lazy. Some are easily amused. Some are easily bored. I now appreciate the fact we all have different levels of reinforcement for life in general. It has a bigger impact on our lives than the average person will acknowledge. I know this because I have lived through a shift in my "neurotransmitter noise." It is incredibly real and seemingly beyond my control.
On 7/24/2016 at 8:21 AM, ACCUiTy_drANE said:Gosh, all this talk about anhedonia is really hitting home. Yes, this drug seemed to zap me of my ability to feel any passion or drive. Sometimes I am not sure if it's a PHYSICAL feeling (i.e., fog) preventing me from feeling pleasure, or as if all of my emotions have simply been blunted. It's like I lost the ability to conceptualize any of my feelings or emotions. I never know if I am angry, happy, or irritable, etc. Everything is shallow and fleeting.There seems to be no overarching meaning to my emotions. It really makes me second guess every facet of my life direction.
I have had depression issues before Accutane, but they were in the realm of intense feelings of sadness. My contemporary problems are of a distinctively different brand. In fact, it has shifted how I view life too. Prior to Accutane, I never understood the appeal of drugs. It was because I could enjoy hobbies and simple activities. Now a days, I have no idea what to do with myself when I have time to myself. Video games aren't fun. I can't get hooked on a book. I can't get lost in an idea. I can't fantasize in my head the way I used to. Everything is dull. Now a days, I know what it's like to crave an artificial escape. My proclivity for risk-taking has sky-rocketed. My everyday "neurotransmitter noise" is vastly different than it once was. It makes me wonder what other people feel day-to-day; it makes me wonder what other spectrum people possess. Some people are hyper-motivated overachievers. Some are lazy. Some are easily amused. Some are easily bored. I now appreciate the fact we all have different levels of reinforcement for life in general. It has a bigger impact on our lives than the average person will acknowledge. I know this because I have lived through a shift in my "neurotransmitter noise." It is incredibly real and seemingly beyond my control.
You mean to tell me this feeling his permanent. Ahh all the more reason to die sooner, but not before revenge.
Anyway, if anyone on here wonders what emotional numbness feels like, just listen to this. Now I want you to imagine never being able to feel anything more intense than that for the rest of your life. I hope you now understand why death is so appealing. You are literally stuck in a waiting room that is your mind.
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