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Repairing the long-term damage from Accutane

 
MemberMember
960
(@tryingtohelp2014)

Posted : 03/24/2016 10:56 am

13 hours ago, guitarman01 said:

I imagine if we were actually able to correct the problem there might be numerous growing pains so to speak. still cant tell if coppers a big deal or not. been taking at least 8mg a day. I feel it in my feet, in my shoulders. im not sure how the process would work. we could get bone pains that could actually be some sort of bone remodeling that could strengthen and thicken them.

if it does start working, these are the exact symptoms i would expect. things being turned on again, simultaneously, some vitamin A metabolite being released from the liver. so oily and extreme dryness at the same time, until you cross some type of threshold. bone pain would be from higher serum Vitamin A induced by copper, at the same time its reducing the overall liver content.

it is as simple as this study. accutane induces ceruloplasmin 4x the normal amount while being treated until copper is clinically deficienct. this depletes the body (specifically the liver) of copper. but this study also mentions rat livers being repleted with 13 cis retinoic acid. so again, how can people say it isnt stored in some way?

when you have available copper, your bodies response to 13 cis retinoic acid is to rapidly increase ceruloplasmin. WHY??

when your body is drained of copper, and you continue taking 13 cis-retinoic acid, your body cant manufacture ceruloplasmin. WHY???

Why does copper amine oxidase get upregulated the same amount as a retinoid binding protein during treatment? WHY???

is this the process of how it starts getting stored long term in some people?!

Induction of ceruloplasmin synthesis by retinoic acid in rats: influence of dietary copper and vitamin A status.

Abstract

Ceruloplasmin, a copper-containing acute phase plasma protein, has been shown to be regulated by 13-cis retinoic acid in rats. Ceruloplasmin activity was significantly increased within 24 h and remained elevated for at least 72 h after a single injection of 13-cis retinoic acid. With daily injections of retinoic acid, the ceruloplasmin activity continued to increase for at least 4 d. After 4 d, the activity was four times control levels. In copper-deficient rats, the ceruloplasmin activity did not increase in response to retinoic acid unless copper was also given to these rats 8 h after retinoic acid. Actinomycin D blocked the retinoic acid-induced stimulation of ceruloplasmin activity in copper-sufficient rats, but in copper-deficient rats only about half of the increase was blocked when the rats were given copper or copper and retinoic acid. By use of pulse-labeling techniques, ceruloplasmin synthesis was shown to increase 1.5-fold after retinoic acid and this increase was blocked by actinomycin D. When vitamin A-deficient rats were repleted with 13-cis retinoic acid for 3 or 5 d, both the ceruloplasmin activity and synthesis were significantly stimulated when compared to the nonrepleted, deficient rats. Therefore, the dietary components, copper and vitamin A, play an important role in the regulation of plasma ceruloplasmin levels.

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28
(@trantran83333)

Posted : 03/24/2016 8:07 pm

Hello again everyone, just wanted to post an update on my journey to recovery.

Last time I spoke about Humaworm, I have now finished my 30 day course of Humaworm 2 weeks ago. Currently on a 90 day break then back on it again for another 30 days.

currently using a parasite zapper along with colloidal silver to keep parasites under control and kill eggs until my next Humaworm. Apparently they reproduce by thousands :-O
Also doing a candida and colon cleanse
and taking Thorne's SF722 formula ( 10-Undecenoic Acid ) for breaking up candida biofilms

symtoms that I don't feel anymore/improved are:
brain fog
anxiety
nervousness
depression
heart palpitations
bright light sensitivity
more energy during the day and more extrovert
Fatigue andred eyes ( improved by 70% )

i still get tired early around 11:30pm
eye sight/night blindness still pretty bad but, I know it's not permanent because I can see better some days.
Occasional bloating/ flatulence

I'm so glad I have found the answer to my suffering and I do wish everyone here all the best!

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MemberMember
1753
(@truejustice)

Posted : 03/24/2016 11:25 pm

3 hours ago, trantran83333 said:

Hello again everyone, just wanted to post an update on my journey to recovery.

Last time I spoke about Humaworm, I have now finished my 30 day course of Humaworm 2 weeks ago. Currently on a 90 day break then back on it again for another 30 days.

currently using a parasite zapper along with colloidal silver to keep parasites under control and kill eggs until my next Humaworm. Apparently they reproduce by thousands :-O
Also doing a candida and colon cleanse
and taking Thorne's SF722 formula ( 10-Undecenoic Acid ) for breaking up candida biofilms

symtoms that I don't feel anymore/improved are:
brain fog
anxiety
nervousness
depression
heart palpitations
bright light sensitivity
more energy during the day and more extrovert
Fatigue andred eyes ( improved by 70% )

i still get tired early around 11:30pm
eye sight/night blindness still pretty bad but, I know it's not permanent because I can see better some days.
Occasional bloating/ flatulence

I'm so glad I have found the answer to my suffering and I do wish everyone here all the best!

Thanks for updating everyone on your success! A couple of questions, is Humaworm a product or is it a parasite killing program that you go on, I can't find it if it's a product?

Thorne's SF722 sounds like a great product for restoring gut health! Did you ever suffer from chronic dryness post accurate?
if so, have you had any success in recovering from the dryness with the program you've been on?
All the internal cleansing is great but how do you get moisture back into the body again? That's what I struggle with - so dry all the time 🙁

You also mention doing a candida and colon cleanse - surely the Humaworm would be taking care of these 2 things anyway wouldn't it??

I recently did a liver/gallbladder cleanse which includes having to do 2 colon cleanses in the process. I think I'm now ready to kill candida and parasites etc and work on fixing my overall gut health.

Thanks again.

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MemberMember
1
(@carlesenagrag)

Posted : 03/26/2016 11:26 am

Hello everyone,

I am new to this forum and am hoping someone here can help me with my condition - and hopefully others also as a result.

My name is Carl. I'm 31, male, and since coming off a 5 month course of Accutane in 2002, have been suffering for 13 years from severe and chronic 'dry' facial skin (as well as permanently dry/sore eyes and dry lips, but I cope with them better).

The dryness never went away after stopping Accutane. I've lived a nightmare ever since. My facial skin is permanently dry, flaky, scaly, itchy, tight, peeling and sore - all this exists together with my Seborhheic Dermatitis and Rosacea and moderate Acne I have had since I was 16.

I've tried everything: topical, oral, dermatological, nautural, homeopathic, supplementary, moisturisers, diet, you name it.

The last 2 years things have gotten totally out of control.

I still produce Sebum strangely, but my face simply doesn't absorb any moisture. It is impossible to moisturise it. This is a nightmare for me, and also means it is impossible for me to conceal my SD, Rosacea and Acne via use of camouflage and concealers because anything I put on my skin just crumbles and flakes over the top of this permanetly dry scaly layer that sits on the surface.

Also, air conditioning and excess heat or cold also makes these 'dry' symptoms even worse.

Is there anything anyone can suggest to treat this problem?

I am 100pc sure that Accutane caused this and I know it is an internal problem. My face was never 'dry' until Accutane. In the last 18 months I have cut out sugars and dairy, which has helped a fair bit with my Rosacea, SD and Acne, but it has done nothing for my dryness. I also take a lot of supplements but have not noticed any improvements with my dryness.

I currently wash using Dermol 500 and a natural exfoliator (as well as Clarisonic once every 2 days), and use a couple of plant based natural moisturisers that don't aggravate my sensitive skin.

If anyone can suggest any topical/natural products/moisturisers or any supplements, or anything they think can help me I would really appreciate it.

I've read as much as I can from this thread - but obviously 360 pages is a lot! - and I've noticed a few others have suffered from permanent dryness such as Chico. Any help from those who have been through the same thing would be appreciated.

I have been looking for a post Accutane support group that deals with permanent dryness for a long time, so I really hope I can find some answers here!

Thanks

Carlo

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MemberMember
47
(@walden-rev)

Posted : 03/26/2016 1:16 pm

Causes of a high total cholesterol with poor ratio

  1. Diet high in sugar and refined carbohydrate
  2. Poor anti-oxidant status. See Antioxidants
  3. Vitamin D deficiency. Cholesterol is the raw material which, through the action of sunshine on the skin, is converted to vitamin D. If the body perceives the deficiency in vitamin D3, and this is almost universal in our low sunshine climate, then the liver pushes out more cholesterol so that when sunshine does land on the skin there is plenty of substrate for vitamin D3 to be made. Vitamin D3 deficiency is itself a major risk factor for arterial disease.
  4. The wrong sort of exercise. See Exercise - the right sort
  5. Borderline hypothyroidism. Indeed 30 years ago a raised cholesterol was almost routinely treated with thyroid hormones. See Hypothyroidism
  6. Vitamin B3 deficiency. B3 is essential for the metabolism of cholesterol and deficiencies are common. The converse is also true - high levels of vitamin B3 bring cholesterol levels down. The only problem is that the form of B3 which does this has a tendency to cause flushing. The body does acclimatise to this and so one needs to start off with small doses, such as 100mgs three times daily, and build up gradually.
  7. Iodine deficiency. See Iodine - what is the correct daily dose?
  8. Low levels of DHEA
  9. High levels of trans fatty acids in the diet
  10. Copper deficiency. There is an inverse relationship between cholesterol levels and copper - so the higher the copper in the blood (so long as it is in the normal range) the lower the cholesterol and vice versa. The best test of copper is to measure superoxide dismutase (SODase), another vital anti-oxidant, since this is a good functional test of copper (and, incidentally, also of zinc and manganese levels).

Number 3 and 10 are confirmed on tests run by members of this board.
Lets see what copper supplementing does + Vitamin D3

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MemberMember
1803
(@guitarman01)

Posted : 03/26/2016 2:04 pm

just wanted to say im stopping copper for the moment. got to give my body a break. anyone trying out copper my thoughts are dont go higher then 4mg per day. maybe just 2mg (this is all they use to treat deficiency anyways) they say the upper limit is 10mg. but after hovering around this amount for a period of time, i realize there is no way my body can handle this much. this just goes back to gut/liver issues or something else is fd up.

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MemberMember
157
(@tanedout)

Posted : 03/26/2016 6:01 pm

Just been doing some more reading up on gut health and I think everyone probably suffers from at least the following conditions;

Gut Dysbiosis (out of balance good/bad bacteria). This goes onto lead to a whole host of things like candida/other yeast overgrowth, potential pathogens and parasites, as well as affecting how vitamins are absorbed/utilised by the body. Everyone on this thread (including me), and all the PFS guys who've had gastrointestinal tests carried out have basically confirmed dysbiosis, but also the one consistent factor has been no growth at all of the lactobacillus good bacteria species, which amongst other things is involved with the production/synthesis of folate, and this is obviously an essential component for methylation, which it appears is messed up in our cases.

The ability to produce folate has been intensively investigated in manyLactobacillusisolates from a variety of origins

Efficiency of DNA replication, repair and methylation are affected by folate, therefore high amounts of folate are required

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257725/

Intestinal Permeability (Leaky Gut). This allows potentially harmful substances to get through the intestinal lining and into your blood stream, resulting in the body triggering an autoimmune response, leading to inflammation. Again I think this probably goes hand in hand with the above.

Prevention of the entrance of toxic or infectious molecules, such as solutes, antigens and microorganisms, is ensured by the gastrointestinal lining. A key structure of the intercellular space is the tight junction, which plays a major role in regulating the paracellular passage of luminal elements.9,10Therefore, proper functioning and regulation of tight junctions is crucial. These junctions are under the influence of intestinal microflora, inflammation and even alimentary components, which can compromise tight junctions.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898551/

My protocol recently (after getting gastrointestinal testing done) has involved trying to remove sugar from my diet (easier said that done as it's in just about everything, not just sweet stuff!), reducing gluten, and taking 'Now Candida Cleanse' for a couple of weeks (this actually resulted in a 'die off' [Herxheimer reaction] - apparently as bad yeasts/bacteria die-off en-masse) for a day or two where I got a constant moderate headache. After about 10 days I introduced home made kefir, which triggered a much more severe die-off reaction where I got a ready bad headache which reduced over 3 days, but fine since, and more recently I've also introduced home made sauerkraut. This also triggered a die-off reaction when I ate loads initially, but then I slowly reduced the amount and built up and now it's fine.

Kefir milk appears to have had a positive effect on mental clarity, however I think this may actually potentially feed candida overgrowth as a negative. I've developed a white coating on the back of my tongue (which I've had in the past), so I've dropped kefir milk, but am currently making coconut kefir which has far less yeasts. I've also just introduced Mutaflor (German probiotic), but this hasn't resulted in any sort of die-off reaction, and so far I've noticed nothing from it.

Regarding leaky gut, I've ordered some glutamine. Apparently this has been shown in studies to be extremely effective at repairing intestinal lining, but in fairly high doses (0.5g/KG of patient, the study with dosage looks at people with Crohns)

http://link.springer.com/article/10.1007%2Fs10620-011-1947-9

Another study suggests 3 x 6g of glutamine per day.

Curcumin has also been shown to help with reducing intestinal permeability, however I've not got on well with this previously, but may introduce.

Also I remember someone mentioned a while ago about someone getting 'cured' with St Johns Wort? I wonder if this could be why?..

St. John's Wort (Hypericum perforatum):Best known for its antidepressant action, hyperforin fromHypericum perforatumalso shows impressive antibacterial action, particularly against gram-positive bacteria such asStaphylococcus aureus

http://www.naturopathydigest.com/archives/2006/jun/vasquez.php

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MemberMember
1803
(@guitarman01)

Posted : 03/26/2016 10:37 pm

Also look into zinc carnosine. I just started taking this today. Gastrointestinal Dr's use this to help repair gut lining. I think the dose is around 50mgs a day for at least 2 weeks. This also raises testosterone. They say there are no good test to measure zinc status in the body. I know this works against the whole copper thing. And people have messed with zinc before. But maybe not this kind. This could maybe be beneficial on multiple levels.

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MemberMember
0
(@abi72)
MemberMember
1
(@carlesenagrag)

Posted : 03/27/2016 11:42 am

Hello again everyone! Following on from my message yesterday regarding my 13 years of post-Accutane chronic dryness on the face (any replies or help would be really appreciated for that), I'm attaching the results of blood tests I had 2 years ago at a natural clinic which tested my Biochemistry, Endrocrinology, Haemotology and microbial Organic Acids.

Perhaps these results may be useful to read.

To explain the data, the number-number in the far right column on pages 1 and 2 are the average range for a healthy person. The number in the second column is me. There is an * where I am not in the range. As you can see I am very low with Serum (Folate) which was the main observation from the rest.

On page 3, the results are pretty easily read and there is a H where I am not in range.

Thanks, and any help or suggestions would be appreciated. I have already been recommended by a fellow user with a similar problem to me to get further tests on: RBC copper, a ceruloplasmin test, RBC zinc test and a RBC manganese test.

Thanks

Carlo

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MemberMember
157
(@tanedout)

Posted : 03/27/2016 12:30 pm

@carlesenagragThanks for posting up your results. As per usual, mostly in range! Although I see folate is a fair bit below. My guess would be that you've got no growth of lactobacillus in your gut (as seems to be a common factor across accutane/PFS sufferers), and this could be a consequence of that.

A bit surprised to see white blood cell count is normal, I would've expect this to be elevated.

Have you tried following any sort of specific diet? I think the GAPS (gut and psychology syndrome) diet is definitely worth following if you can actually stick to it (clearly not easy), but it seems to have yielded significant improvements for people suffering from similar conditions to ours (although I don't know anyone who's actually tried this long term on this thread)

The premise of the GAPS diet is that there is a correlation between the state of your intestinal flora and your brain chemistry.

http://www.livestrong.com/article/469984-what-is-the-gaps-diet/

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MemberMember
1
(@carlesenagrag)

Posted : 03/27/2016 1:34 pm

Hi @tanedout - thanks for reveiwing my results.

The test was done 2 years ago at a natural health clinic at Harley Street, London. I was subsequently put on a 4-5 month course of supplements, probiotics and prebiotics and a special diet, designed to clean out my insides. Bear in mind I went to the natural clinic not only for my dry skin, but also for my SD and Rosacea, which have improved over the last 2 years - although I'm mainly house bound which means I avoid a lot of my environmental triggers. However, this course of supplements and dieting didn't do anything for my dryness.

Over the last 13 years I've been on loads of diets. I've now got to a point where I know what not to eat in order to improve my SD and Rosacea. I eat no sugar or dairy products, no fried food, sweets, chocolate, caffeine, and a few other foods. Eliminating these really helps my SD and Rosacea. But unfortunately I've never noticed any difference to my dryness caused by Accutane with diet or supplements. I've tried loads of supplements through the years too, and am taking a tonne now also.

The only thing that has ever been a massive help to my dryness was Tacrolimus (Proptopic) ointment, which is an immunosuppresive drug which I put on my face. That is the only thing I have ever used that was actually absorbed by my skin. However after using it for a few years, it then stopped working/absorbing also.

I'm going on now! Thanks for the lactobacillus suggestion ... although according to my natural doctor that should have been cured by my course of supplements and diet 2 years ago. I'll look into the GAP diet too

One question I do have... is there any general advice or suggestions for all post-Accutane sufferers of what we can do to overturn our issues? Or is it a case of everyone being different?

I am in a desperate situation where I am sure now that Accutane is the cause, but I don't know what to do or who to go to for help and treatment about it!

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MemberMember
1803
(@guitarman01)

Posted : 03/27/2016 2:53 pm

another update. just when i thought i was going to swear off copper for awhile. idk, i might seriously be growing new fine baby hairs along my temples, i can feel them with my fingers. if this really was the case this would be insane. not for sure yet though. im going to stay back on a modest dose of copper 2 to 4 mg per day and try to restrain myself from taking higher doses. I think i might have ibs type symptoms going on and i believe culturelle (especially the one i got now with inulin might have made bloating, getting backed up from the copper much worse) So im switching back to align with my lower dose copper and see how that goes. align and vsl are the only proven probiotics that help with ibs(which could be bloating,constipation,overall nauseous feeling,abdominal pain). so thats all i got for now. until i change my mind in like a day or two. hopefully not though.

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MemberMember
28
(@trantran83333)

Posted : 03/27/2016 6:05 pm

On 25 March 2016 at 2:55 PM, TrueJustice said:
Thanks for updating everyone on your success! A couple of questions, is Humaworm a product or is it a parasite killing program that you go on, I can't find it if it's a product?

Thorne's SF722 sounds like a great product for restoring gut health! Did you ever suffer from chronic dryness post accurate?
if so, have you had any success in recovering from the dryness with the program you've been on?
All the internal cleansing is great but how do you get moisture back into the body again? That's what I struggle with - so dry all the time :(

You also mention doing a candida and colon cleanse - surely the Humaworm would be taking care of these 2 things anyway wouldn't it??

I recently did a liver/gallbladder cleanse which includes having to do 2 colon cleanses in the process. I think I'm now ready to kill candida and parasites etc and work on fixing my overall gut health.

Thanks again.

 

I did write a reply but got deleted somehow, possibly because of the links....

humaworm is an excellent product, in my opinion.
You should look into it and add their Facebook support page, there all members are very supportive and answer any questions you may have plus u can read up people's experiences/journey with Humaworm. 
Look up Humaworm parasite removal and natural health group 

for people suffering with ED, I have heard or read that parasites can cause ED. I'm a girl so I don't experience that, you might want to google erectile dysfunction and parasites

As for dry skin, mine has improved significantly! My whole body and face was so dry my body was unable to absorb water. My cuticles were so dry and cracked that they will bleed. It was so painful. 

Humaworm has taken care of my candida, there's no denying that. I no longer have thrush, that yellow smelly discharge. But I want to make sure I don't go back to feeling the way I did these last 3 years.

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MemberMember
28
(@trantran83333)

Posted : 03/27/2016 6:51 pm

My question is, how did all this get out of control?
From what I know is that parasites and candida are just opportunist bugs.

one of the theories is copper ( btw I heard that liquid ionic copper is better as tablet can be toxic to the body after a while)

2nd suspect is Mercury toxicity/poisoning. But I can't find any links for Accutane and Mercury 
but found this....

ideas anyone? Does anyone here have silver amalgam fillings? 
I had a tetanus shot as I was bitten by a rat... Yeh yuck!

image.thumb.jpeg.c3428d939522a298fea1671

 

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MemberMember
0
(@abi72)

Posted : 03/28/2016 4:31 am

16 hours ago, carlesenagrag said:

Hello again everyone! Following on from my message yesterday regarding my 13 years of post-Accutane chronic dryness on the face (any replies or help would be really appreciated for that), I'm attaching the results of blood tests I had 2 years ago at a natural clinic which tested my Biochemistry, Endrocrinology, Haemotology and microbial Organic Acids.

Perhaps these results may be useful to read.

To explain the data, the number-number in the far right column on pages 1 and 2 are the average range for a healthy person. The number in the second column is me. There is an * where I am not in the range. As you can see I am very low with Serum (Folate) which was the main observation from the rest.

On page 3, the results are pretty easily read and there is a H where I am not in range.

Thanks, and any help or suggestions would be appreciated. I have already been recommended by a fellow user with a similar problem to me to get further tests on: RBC copper, a ceruloplasmin test, RBC zinc test and a RBC manganese test.

Thanks

Carlo

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Sorry, I am new to all this so can't help. That test looks realy inclusive - what is the test called and how much does it cost? Thanks and good luck.
 

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MemberMember
157
(@tanedout)

Posted : 03/28/2016 4:47 am

@trantran83333Good to hear you're getting some good results from that product! Have you been on any sort of specific diet while taking the humaworm, i.e. no sugar, avoiding things with lots of yeast etc? Did you experience any sort of 'die-off' effect when you started taking it? (Herxheimer effect). How long did it take you see results?

I got hold of some 'Now - Candida Support' (which has many of the same ingredients as humaworm) which I started taking while I was waiting for my gastrointestinal results and I noticed a die-off effect from this, plus improved mental clarity, but I stopped when I got my results back and they showed no growth of lactobacillus bacteria so I started drinking a load of homemade kefir milk to start trying to restore that, however this has definitely resulted in some sort of yeast overgrowth, most likely candida, as I've got a white coating on the back of my tongue now. I've stopped drinking milk kefir as a result, and am sticking to homemade sauerkraut and back on the Now Candida Support, but may look at humaworm if you've found it really effective

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MemberMember
1
(@carlesenagrag)

Posted : 03/28/2016 5:13 am

On 3/28/2016 at 5:31 PM, hatetane said:

Sorry, I am new to all this so can't help. That test looks realy inclusive - what is the test called and how much does it cost? Thanks and good luck.

Hiya. It was very expensive. Several hundred pounds iirc. There wasn't a specific name for the test as it was personalised for me. After a consultation, they book you for blood tests based on your problems then put you on a treatment plan. The clinic is called Claudia Louch, based in Harley Street, London. Everything they supply is natural and plant-based, which is the one positive thing about them. I have very sensitive skin and I don't react with their products. But like I said, my dryness has not improved at all since going there. Very expensive, too. You can see the tests they do here if this works, otherwise just google Claudia Louch and navigate from their [Edited link out]

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MemberMember
28
(@trantran83333)

Posted : 03/28/2016 8:10 am

3 hours ago, tanedout said:
@trantran83333Good to hear you're getting some good results from that product! Have you been on any sort of specific diet while taking the humaworm, i.e. no sugar, avoiding things with lots of yeast etc? Did you experience any sort of 'die-off' effect when you started taking it? (Herxheimer effect). How long did it take you see results?

I got hold of some 'Now - Candida Support' (which has many of the same ingredients as humaworm) which I started taking while I was waiting for my gastrointestinal results and I noticed a die-off effect from this, plus improved mental clarity, but I stopped when I got my results back and they showed no growth of lactobacillus bacteria so I started drinking a load of homemade kefir milk to start trying to restore that, however this has definitely resulted in some sort of yeast overgrowth, most likely candida, as I've got a white coating on the back of my tongue now. I've stopped drinking milk kefir as a result, and am sticking to homemade sauerkraut and back on the Now Candida Support, but may look at humaworm if you've found it really effective

Um yeh the yeast ate all your good bacteria I would assume.

Then you added kefir milk which has yeast contents in it so you were helping the bad guys lol.

i was told by my naturalpath to stay away from fermented foods.

i believe milk kefir, fermented foods are to improve an already healthy persons health which is no use to us. We are wayyy out of balance

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MemberMember
1803
(@guitarman01)

Posted : 03/28/2016 8:15 am

well scratch copper again. i cant even take 4mg atm without getting pain in my side. So that cant be good. its also causing alot of my body hair to fall out, similar to when i came off accutane. So is there anything to this? idk but i have to lay off, till i feel normal again.
In the mean time going to take high dose glutamine and align.

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MemberMember
42
(@relentless-to-find-tane-cure)

Posted : 03/28/2016 9:00 am

21 hours ago, carlesenagrag said:

Hello again everyone! Following on from my message yesterday regarding my 13 years of post-Accutane chronic dryness on the face (any replies or help would be really appreciated for that), I'm attaching the results of blood tests I had 2 years ago at a natural clinic which tested my Biochemistry, Endrocrinology, Haemotology and microbial Organic Acids.

Perhaps these results may be useful to read.

To explain the data, the number-number in the far right column on pages 1 and 2 are the average range for a healthy person. The number in the second column is me. There is an * where I am not in the range. As you can see I am very low with Serum (Folate) which was the main observation from the rest.

On page 3, the results are pretty easily read and there is a H where I am not in range.

Thanks, and any help or suggestions would be appreciated. I have already been recommended by a fellow user with a similar problem to me to get further tests on: RBC copper, a ceruloplasmin test, RBC zinc test and a RBC manganese test.

Thanks

Carlo

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For the most part you are just lacking potassium and folate, which is common if you dont eat a lot of greens n fruit. If you do then that supports my theory of messed up folate metabolism/cycle from accutane. Same theory Rich van Konyenburg made.

My folate is  high however, but i supplement all the forms

The microbial organic acids test i have no clue how to interpret as i dont study that stuff, sorry

Low potassium could explain if you have high heart rate, heart palpitations or shortness of breath. Also muscle weakness. Especially if you start taking folate supplements or eating more leafy greens you also need to get more potassium since the new cells folate create will need it. Serum potassium drops fast when u get folate up.

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/28/2016 10:32 am

1 hour ago, Relentless1k said:
For the most part you are just lacking potassium and folate, which is common if you dont eat a lot of greens n fruit. If you do then that supports my theory of messed up folate metabolism/cycle from accutane. Same theory Rich van Konyenburg made.

My folate is  high however, but i supplement all the forms

The microbial organic acids test i have no clue how to interpret as i dont study that stuff, sorry

Low potassium could explain if you have high heart rate, heart palpitations or shortness of breath. Also muscle weakness. Especially if you start taking folate supplements or eating more leafy greens you also need to get more potassium since the new cells folate create will need it. Serum potassium drops fast when u get folate up.

Rich Van K never figured out why high doses of methyl folate (deplin) didnt help people with this methylation problem.  its obvious we have methylation issues (just say detoxification issues)   accutane cause an alteration in methyl group status (severe losses).... that much is 100% confirmed.   and as we continue to waste, by gut dysbosis/parasites/SIBO etc etc ec.... it doesnt get better.

Before you even get to the folate metabolism, the methionine synthase has to be fixed.

like trantran said... candida or parasites or a probiotic problem are all symptoms, not the cause.   they are opportunistic.   they are present in all of us ALL the time.   fixing these symptoms wont cure anything imo.  you can take months to beat these parasites down... then the second you stop an extreme diet, or cleanse, they  will be right back in full force unless you fix the underlying problem.

2016-02-19_2005.png

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MemberMember
1
(@carlesenagrag)

Posted : 03/28/2016 2:45 pm

5 hours ago, Relentless1k said:
For the most part you are just lacking potassium and folate, which is common if you dont eat a lot of greens n fruit. If you do then that supports my theory of messed up folate metabolism/cycle from accutane. Same theory Rich van Konyenburg made.

My folate is high however, but i supplement all the forms

The microbial organic acids test i have no clue how to interpret as i dont study that stuff, sorry

Low potassium could explain if you have high heart rate, heart palpitations or shortness of breath. Also muscle weakness. Especially if you start taking folate supplements or eating more leafy greens you also need to get more potassium since the new cells folate create will need it. Serum potassium drops fast when u get folate up.

I have always had plenty of fruit and enough greens, so yes perhaps it does suggest Accutane messing up the folate metabolism. I have been supplementing with folic acid for several months mind and noticed no difference once again.

Does anyone here know if there is anyone professionally we can go to to work with regarding what is discussed here? This thread is fantastic, proactive and I really hope we can find the answers. I also fully am aware after 13 years of little help from dermatologists just how hard it is to get what you need from the medical/big pharma industry. But perhaps there are professionals out there, like naturopaths for example, who we can go to and explain that 'Accutane caused this, this is what I think I may be lacking, can you work with me, do tests, put me on a treatment plan bla bla bla'

Basically, what I am saying is I am sick and tired of fighting this alone (in the literal sense, obviously this thread and other forums are great for help and support and suggestions). For years and years, I have tried this, I have tried that, I have tried this supplement, this suggestion, this natural product, this drug etc etc.

I would dearly love to work alongside a professional (not a dermatologist) who can work with me on a post-Accutane plan and go through everything discussed here and more. I don't care about the money.

I'm sure many here would love to do the same. I saw one person mention Genova Diagnostics - maybe someone like them for example would work with individuals like us?

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Justmom, Justmom and Justmom reacted
MemberMember
28
(@trantran83333)

Posted : 03/29/2016 5:27 am

Thought this might be useful for @tryingtohelp2014 

image.thumb.jpeg.61a50ddea0ecfe2ad5a4fb8

This was written by Andy cutler 

for some reason I think there is a link between copper and Mercury 

ALA is used to chelate Mercury for people with Mercury toxicity
at the same time ALA make copper levels go up.... Hmm 
and we are low copper? 
I don't know trying to think outside the box. 
Ideas anyone?

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MemberMember
1803
(@guitarman01)

Posted : 03/29/2016 2:32 pm

On 3/28/2016 at 10:32 AM, tryingtohelp2014 said:
Rich Van K never figured out why high doses of methyl folate (deplin) didnt help people with this methylation problem.  its obvious we have methylation issues (just say detoxification issues)   accutane cause an alteration in methyl group status (severe losses).... that much is 100% confirmed.   and as we continue to waste, by gut dysbosis/parasites/SIBO etc etc ec.... it doesnt get better.

Before you even get to the folate metabolism, the methionine synthase has to be fixed.

like trantran said... candida or parasites or a probiotic problem are all symptoms, not the cause.   they are opportunistic.   they are present in all of us ALL the time.   fixing these symptoms wont cure anything imo.  you can take months to beat these parasites down... then the second you stop an extreme diet, or cleanse, they  will be right back in full force unless you fix the underlying problem.

2016-02-19_2005.png

pump the brakes on copper. this might be one of the more dangerous supplements ive taken. im having abdominal pain and serious constipation. I am not, and nore should you convince anyone to take this at this point. what you are saying is all speculation. i am concerned for myself right now and if this pain dosent go away real soon. im going to have to go to the hospital. you want this to be it. youve been here before. id think twice about taking anymore copper yourself. what ive taken should be a reasonable dose. maybe copper interaction with accutane was/is our problem all along.

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