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ok so I took some high dose b1 yesterday and the day before 300mg just for the sake of trying everything and it really, really dried out my skin, my sinuses and my tongue/mouth.So a few questions I ask myself. is my skin already prone to dryness post accutane? yes. Why would b1 itself cause such dryness? is it competing with some other hidden deficiency that was made worse by taking this high dose? Is this somehow pushing vitamin a/accutane back into circulation? my skin/dryness can be so much better or worse on any given day. So would I assume when its bad I have more accutane/vitamin a in my circulation? I dont know.
For the theory that we still have mass amounts of accutane stored in our liver and we need to release it and excrete it, if this was true how long would this process take? I mean I took accutane like 15 years ago! If it was a long slow process that needed assistance by supplements, I just dont think I could deal with the ongoing systemic dryness with the thought that if certain supplements that I take that really dry me out are actually doing me good? the problem is we dont know if its the actual supplements or if its really stirring accutane up from the liver.
On 1/9/2016, 1:13:08, vampirevampire said:Has anyone managed to cure hair thinning issue? (5 months post accutane) If this has been discussed in detail can you please tell me approx what page is it on? Thanks
It can stop with time, proper diet and supplements. My hair doesnt grow back (i lost quite a bit) but it regained thickness and color (not to the old pre accutane state but still far better than after accutane) I had nearly grey hair and it was like dry grass at 18 years old, now at soon 21 its pretty decent and dark brown.. If it was just time or the massive effort i spent into eating healthy and supplementing important healing nutrients is unknown. Probably a combination. I might also just be lucky
-----
Im nearly bodybuilding stage bodyfat mode because i lost so much weight gradually after accutane, this could perhaps mean i have gotten rid of any accutane stored in fat. Was it concluded that an autopsy was needed to check accutane in the liver?
I can vouch for methionine and sam-e etc, but isnt there a worrysome effect it can have by driving homocysteinetoo low?
http://onlinelibrary.wiley.com/doi/10.1002/bdra.10036/full
Combination therapy with folic acid and methionine in the prevention of retinoic acid-induced cleft palate in mice
48 minutes ago, vianello said:http://onlinelibrary.wiley.com/doi/10.1002/bdra.10036/full
Combination therapy with folic acid and methionine in the prevention of retinoic acid-induced cleft palate in mice
It looks likes the reason for the protection is: methionine is formed faster and lost slower when folate is added. TMG also helps.
http://www.jbc.org/content/189/2/515.full.pdf
Livers from folic acid-deficient chicks oxidized choline at a reduced rate and exhibited a reduced ability to form methionine from homocysteine or homocystine in the presence of added choline or betaine. Chick kidney choline oxidase was not significantly reduced in folic acid deficiency. Dietary supplements of betaine, methionine, or creatine did not alleviate the syndrome of folic acid deficiency in the chick. The addition of folic acid in vitro enhanced the rate of methionine formation by folic acid-replete chick livers but not by folic acid-deficient chick livers
The data presented in this paper suggest that folic acid is involved in the conversion of choline to betaine and in transmethylation from betaine to methionine.
For anyone curious about the methylation pathways (and MANY other pathways), this is the best chart I could find: (TY Ben Lynch!)
[Edited link out]
I printed this out fully with 20 sheets of paper and taped it all together and placed it on my wall. Helps me understand it more easily.
Also, if you've had the 23andme test, you may want to label or color code the SNPs on the chart as well.
Regarding the post above, for people that don't know, TMG is a type of betaine. Glycine betaine specifically. Choline can help create TMG which can create methyl-homocysteine (methionine). The other way to create methionine is through the MTR pathway (folate, zinc, functional MTHFR enzyme).
Methylation basics:
[Edited link out]
13 minutes ago, yetanotheraccutanevictim said:For anyone curious about the methylation pathways (and MANY other pathways), this is the best chart I could find: (TY Ben Lynch!)
http://www.evernote.com/l/AbHminycBGVP2qJWC6uXx0l3kZW4HF_0vM8/I printed this out fully with 20 sheets of paper and taped it all together and placed it on my wall. Helps me understand it more easily.
Also, if you've had the 23andme test, you may want to label or color code the SNPs on the chart as well.Regarding the post above, for people that don't know, TMG is a type of betaine. Glycine betaine specifically. Choline can help create TMG which can create methyl-homocysteine (methionine). The other way to create methionine is through the MTR pathway (folate, zinc, functional MTHFR enzyme).
Methylation basics:
Thanks for info on TMG - much appreciated.
Has anyone taking folic acid??
interesting when I looked at those who need it - mentioned people who are 'anaemic' benefit from taking it. I feel week just about every day, I get tired easily and people often say I look very pale - wonder if folic acid supplementing might help?
I took Metionine the other day and sure enough I felt like I couldn't breathe when I went to bed - I had those aweful panic attacks that come post accutane so I've decided to stop. I might need to take it with claritin or something - not 100% what to do.
Has anyone addressed cleaning or boosting the kidneys?? If so what are some of the better products or tinctures to use??
If we are going to clean the liver, might as well clean up the kidneys I reckon. The only other thing to clean would be the colon and bowels I think? ( which I've done on numerous occasions )
Its not like there's a spleen or pancreas cleansing diet....I'm sure all these other cleanses help these organs too during and after the process!!!
instictively though - liver & Kidney seem like they definitely need further cleaning and attention.
1 hour ago, TrueJustice said:Thanks for info on TMG - much appreciated.Has anyone taking folic acid??
interesting when I looked at those who need it - mentioned people who are 'anaemic' benefit from taking it. I feel week just about every day, I get tired easily and people often say I look very pale - wonder if folic acid supplementing might help?I took Metionine the other day and sure enough I felt like I couldn't breathe when I went to bed - I had those aweful panic attacks that come post accutane so I've decided to stop. I might need to take it with claritin or something - not 100% what to do.
Has anyone addressed cleaning or boosting the kidneys?? If so what are some of the better products or tinctures to use??
If we are going to clean the liver, might as well clean up the kidneys I reckon. The only other thing to clean would be the colon and bowels I think? ( which I've done on numerous occasions )Its not like there's a spleen or pancreas cleansing diet....I'm sure all these other cleanses help these organs too during and after the process!!!
instictively though - liver & Kidney seem like they definitely need further cleaning and attention.
The methionine could be giving you some type of acid reflux that could feel like a panic attack. Can't say if that's the case though I haven't taken it enough myself in isolation. I know I would have a reaction if it did though because I'm very sensitive to reflux.
10 hours ago, Relentless1k said:It can stop with time, proper diet and supplements. My hair doesnt grow back (i lost quite a bit) but it regained thickness and color (not to the old pre accutane state but still far better than after accutane) I had nearly grey hair and it was like dry grass at 18 years old, now at soon 21 its pretty decent and dark brown.. If it was just time or the massive effort i spent into eating healthy and supplementing important healing nutrients is unknown. Probably a combination. I might also just be lucky-----
Im nearly bodybuilding stage bodyfat mode because i lost so much weight gradually after accutane, this could perhaps mean i have gotten rid of any accutane stored in fat. Was it concluded that an autopsy was needed to check accutane in the liver?
I can vouch for methionine and sam-e etc, but isnt there a worrysome effect it can have by driving homocysteine too low?
I found this relating to your question
Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats.
What supplements are good to improve liver? My Regime: Methionine, Taurine, B Complex, Zinc & Magnesium. Is Methionine contraproductive if my eyes are a Bit (really just a little Bit) yellow or does it improve the liver function? I Do Not want to take glycine because it is an ''antagonist'' of Methionine. Methionine is important for igf 1..
What supplements are good to improve liver? My Regime: Methionine, Taurine, B Complex, Zinc & Magnesium. Is Methionine contraproductive if my eyes are a Bit (really just a little Bit) yellow or does it improve the liver function? I Do Not want to take glycine because it is an ''antagonist'' of Methionine. Methionine is important for igf 1..
Vianello
The old arabs in the time of the Prophet said, that nigella sativa treats every disease beside dead. 
On Wed Jan 06 2016 14:37:34 GMT+0900, Chico Esposito said:So what's the general consensus nowadays because a few years back it ranged fromcannabis oil as a cure all forpost accutane side effects all the way through tothepreposterous like running barefoot will cure you. That's why i had to walk away because it was non stop infighting in between contextlesspeer review studies on every page and it seemed to be going round in a closed circuitloop.
So what have the brightest minds on thesitegot to offer in terms of new breakthroughs....has there been any? and if so what side effects do they displace? I've got some breakthroughs of my own that may help.
hey chico! I've been doing some research on this forum and from independent sources. My biggest problem now I must say is brain fog, memory problems, lack of pleasure in sexual activities and joint pain. I've been taking TUDCA (supplemented with taurine) and couple hours later I take milk thistle, iron, tocopherol based vitamin e so that the tocopherol can displace the retinoic acid molecules and hopefully release them when I poop.Before all of this I take salad with a lot of balsamic dressing with extra olive oil (which is vitamin e essentially) to increase my bile flow. I'm not sure if this will help because I just started my treatment couple days ago....i am really curious as to what you take now?
5 hours ago, manalesenicola said:What supplements are good to improve liver? My Regime: Methionine, Taurine, B Complex, Zinc & Magnesium. Is Methionine contraproductive if my eyes are a Bit (really just a little Bit) yellow or does it improve the liver function? I Do Not want to take glycine because it is an ''antagonist'' of Methionine. Methionine is important for igf 1..
What supplements are good to improve liver? My Regime: Methionine, Taurine, B Complex, Zinc & Magnesium. Is Methionine contraproductive if my eyes are a Bit (really just a little Bit) yellow or does it improve the liver function? I Do Not want to take glycine because it is an ''antagonist'' of Methionine. Methionine is important for igf 1..
Vianello
The old arabs in the time of the Prophet said, that nigella sativa treats every disease beside dead.
I'd be tempted to add TUDCA, in numerous studies it performs very well for various different liver ailments, including fatty liver. I found it improved my mental clarify, but I started to feel a bit shit on it after 4-5 weeks at 600mg/day (it was possibly making me deficient in something, but no idea what, was taking with B6,B12,folate).
Currently taking active B6, B6 and folate, 3g taurine, zinc, selenium and 300-400mg SAM-e (just started this), but will re-introduce TUDCA probably at the weekend. Eating loads of brazil nuts which are a good source of methionine (approx 1000mg per 100g of brazil nuts, although I'm eating 25g/daily).
This guy has been suffering from finasteride sides (the same sort of sides at tane sufferers) for 7 years, but can overcome them when he takes a number of supplements, key ones appear to be TUDCA and choline, and they seem to suggest his issues are with the liver as well (as expected really). He tried to drop TUDCA due to it being fairly expensive, but he relapsed and the sides returned until he restarted it, so it's clearly important for him.
4 hours ago, manalesenicola said:
great little article and easy to read. Im mainly looking at vitamin b2 atm in high doses, say 400mg. look it up on linus pauling there is alot there and alot that could go wrong too that would affect numerous processes in the body.
Hi all. I posted this a few days ago on the general board and have gotten no answers, so please may I ask here? Specifically, I'm trying to find information about OttoVisual and others who used cannabis to attempt to heal their ED, lack of sexual response, and general apathy issues. My son (19 now) took Accutane for two rounds a few years ago. We don't get into the details, but things that used to happen before Accutane, don't happen any more. We live in Colorado, and though our doctor won't really get on board with the idea, he has given us a somewhat green light to try cannabis. But I'm hoping to find details about how much/how often/which strand (I know they mentioned RSO, but am wondering about another.) Here's the quote from my general board question:
Hi all who are helpful. I'm sorry if this question is addressed somewhere, but I've searched the site and can't find an answer. When I put a phrase in the search box, I get many results that I'd like to look at, but then it seems there is no way to get to the individual entry. The results show an entry number, but entry numbers are not shown within the discussions on the forums. Is there a way to make those entry numbers show up? I've also tried clicking on the live link at the top of each result, but it just takes me to the first page of the discussion. Thanks for any help!
@Modeaa
"If the ammonia in the urine is true, i wonder if it's from a state of hyperrammonium or a state of ammonium loss."
It's probably a bit of both. Also, the liver is mainly responsible for converting the waste products of protein metabolism into less harmful components. One of those wastes is ammonia, which comes from the nitrogen released when digesting protein. The liver can only convert so much ammonia into urea at one time. If it's overburdened, more ammonia will have to go through the kidneys or out the skin.
http://pmid.us/4727456 .
18 hours ago, guitarman01 said:
The methionine could be giving you some type of acid reflux that could feel like a panic attack. Can't say if that's the case though I haven't taken it enough myself in isolation. I know I would have a reaction if it did though because I'm very sensitive to reflux.
sounds like a straight panic attack to me. ANYONE having problems taking methionine or SAM-e should have their functional B-12 and Folate checked. Taking 500mg of methionine should be no different than eating a few eggs if youre sufficient in the B's
two tests
for the B12 get a test called: methylmalonic acid (MMA) this gives you a true reading of a potential B12 deficiency
for folate... probably a simple homocysteine test
look at this shit
Retinol and its provitamin A precursors are converted into active metabolites in tissue-specific patterns. Conversion of retinol to retinal and then to all-trans-retinoic acid, the predominant isomer of vitamin A, requires two successive oxidation reactions, first by alcohol dehydrogenases (which contain zinc), and then by either aldehyde dehydrogenase or retinal dehydrogenase (which contains the riboflavin-dependent enzyme, flavin-adenine dinucleotide [FAD]).4
2 hours ago, tryingtohelp2014 said:sounds like a straight panic attack to me. ANYONE having problems taking methionine or SAM-e should have their functional B-12 and Folate checked. Taking 500mg of methionine should be no different than eating a few eggs if youre sufficient in the B'stwo tests
for the B12 get a test called: methylmalonic acid (MMA) this gives you a true reading of a potential B12 deficiency
for folate... probably a simple homocysteine test
Yeah it wasn't due to reflux - that I can handle. I would attribute reflux to fast eating which is a problem I have but not accutane related.
What I felt was more a restriction of oxygen when laying in bed trying to get to sleep. That coupled with lying in the dark just tipped me over the edge where I kept having to get up and walk around the house calming myself down.
This all could of been coincidental but I'm not wanting to go there again right at this minute so I stopped taking methionine supplement by itself - I may come back to it!!
Thanks for passing on possible tests to have done. Currently I'm addressing my bad varicose vein issue - getting some scans done and working out what to do next. Doctor thinks I need to have the veins stripped from my legs but I think this is way too invasive and I'd much prefer an easier method of dealing with this problem!
Just add it to the long list of complications - I can't even be totally sure it's accutane related but my instinct tells me it is. I have to think that my overall fatigue and sluggishness with bad circulation post accutane has something to do with my vein problems.
Similar to the noticeable vein issues that others have reported on before in this forum but not necessarily related to the legs!!
7 hours ago, Justmom said:Hi all. I posted this a few days ago on the general board and have gotten no answers, so please may I ask here? Specifically, I'm trying to find information about OttoVisual and others who used cannabis to attempt to heal their ED, lack of sexual response, and general apathy issues. My son (19 now) took Accutane for two rounds a few years ago. We don't get into the details, but things that used to happen before Accutane, don't happen any more. We live in Colorado, and though our doctor won't really get on board with the idea, he has given us a somewhat green light to try cannabis. But I'm hoping to find details about how much/how often/which strand (I know they mentioned RSO, but am wondering about another.) Here's the quote from my general board question:
Hi all who are helpful. I'm sorry if this question is addressed somewhere, but I've searched the site and can't find an answer. When I put a phrase in the search box, I get many results that I'd like to look at, but then it seems there is no way to get to the individual entry. The results show an entry number, but entry numbers are not shown within the discussions on the forums. Is there a way to make those entry numbers show up? I've also tried clicking on the live link at the top of each result, but it just takes me to the first page of the discussion. Thanks for any help!
Hey Justmom,
I'm sorry for what happened to your son. I also suffer from severely impaired sexual function (alongside many other side effects) as a result of isotretinoin and have tried making and using a cannabis concentrate to resolve the issue. I have taken detailed notes and could perhaps guide you through the process of producing and using the concentrate if you're interested.
I highly recommend that you make your own concentrate so you know exactly what goes into it (no dangerous stuff!). I know that Rick Simpson recommends using all kinds of highly toxic solvents to extract the oil from the plant matter, but I strongly discourage you from doing this. It is needlessly dangerous, and I find it hard to believe that you can truly remove ALL the solvent from the oil (and a few tests have backed up this notion). Please stick to food grade solvents so you don't have to worry about it (190 proof grain/drinking alcohol, such as Everclear, works well enough. I can provide you with a few options if you're interested).
I feel that I cannot say whether or not this treatment could work due to the fact that, because I was in college at the time, I couldn't always ingest the potency that I would have liked to, my first few batches were weak, and I ended up cutting my treatment short for various external reasons. If your son is still at home, this is a good time to try it as he'll have your help and the free time necessary to stick to his dosages and complete his course/s.
Though I can't claim to have definitely experienced any lasting benefits from the incomplete course that I went through (which lasted under two months), I admit that it does perhaps show at least SOME promise as I do reliably get good erections when I get high from vaporizing cannabis. I don't, however, remember ingesting it providing quite the same effect, but perhaps that was just due to the delay before it hits you after ingestion (inhalation is more immediate). I know off the top of my head that at least one person who claimed to have successfully regained sexual function through this method did so after 5 months and another after 3 months. The positive improvements for at least one of these people remained for a least a few months after stopping the cannabis concentrate because he checked back in and gave an update before dropping off the radar for good. I've collected a number of anecdotal claims of marijuana's effectiveness in treating this issue which I could provide you with if you wish (it's rather long so I won't post it here).
Dosage
As far as dosage I can only say that it sounds like most others attempt to follow the dosage that Rick Simpson suggests for cancer treatment. One course of treatment involves the ingestion of 60 grams of oil over a period of 90 days. 1 ounce of flowers should produce about 3 - 4 grams of oil. As I stated above, some people didn't feel fully recovered until 5 months, so you may want to plan for 2 courses.
You will want to incorporate a ramp up period so his body can get used to the dosage slowly. If you start him off at full dosage it will probably knock him out for a few days. If you acclimate him slowly he will be functional. I can provide you with details on my dosage progression if you're interested.
Strain
As far as which strains, I can tell you that I've only ever used indica dominant strains. This is due to Rick Simpson's recommendation. I assume the others probably followed his advice as well.
I'll check back here soon to see if you have any questions, etc.
Just recievedHydroxypropyl-Beta-Cyclodextrin.
did anyone used it already?
Although someone mentioned orally would not be effective, Im guessing all the bodybuilders and the lsd producers take it orally and its working for them. Maybe the stomach acids alters the sugar chain and it will reach the liver altered, its worth trying orally though.
im going to try 1 gram tonight and see what it does. I have the option for IV but will use that option only when its potenency is proved by an other member.
Wald
54 minutes ago, Walden Rev said:Just recievedHydroxypropyl-Beta-Cyclodextrin.
did anyone used it already?
Although someone mentioned orally would not be effective, Im guessing all the bodybuilders and the lsd producers take it orally and its working for them. Maybe the stomach acids alters the sugar chain and it will reach the liver altered, its worth trying orally though.im going to try 1 gram tonight and see what it does. I have the option for IV but will use that option only when its potenency is proved by an other member.
Wald
I'd be starting small and working up if you get no negative effects. You could also consider administering sublingually too, this might be more effective than orally, even on an empty stomach.
3 hours ago, Walden Rev said:Just recievedHydroxypropyl-Beta-Cyclodextrin.
did anyone used it already?
Although someone mentioned orally would not be effective, Im guessing all the bodybuilders and the lsd producers take it orally and its working for them. Maybe the stomach acids alters the sugar chain and it will reach the liver altered, its worth trying orally though.im going to try 1 gram tonight and see what it does. I have the option for IV but will use that option only when its potenency is proved by an other member.
Wald
This would be fantastic. And everyone needs to use the same usernames.
4 hours ago, Walden Rev said:Just recievedHydroxypropyl-Beta-Cyclodextrin.
did anyone used it already?
Although someone mentioned orally would not be effective, Im guessing all the bodybuilders and the lsd producers take it orally and its working for them. Maybe the stomach acids alters the sugar chain and it will reach the liver altered, its worth trying orally though.im going to try 1 gram tonight and see what it does. I have the option for IV but will use that option only when its potenency is proved by an other member.
Wald
Try rectal insertion as well. That way it goes straight to the liver. Do you have a powder or capsules or what?
If you have a powder, mix it with a base like this:
http://pharmlabs.unc.edu/labs/suppository/bases.htm
to increase the absorption and utilization of the suppository.