On 1/8/2016 at 12:42 PM, guitarman01 said:

On 1/8/2016 at 12:36 PM, Mike San said:

 

[Edited link out]

"The most profound change in the concentration of plasma amino acids by excess retinol treatment was the decrease in the concentration of methionine. Regardless of the level of methionine in the diet, optimal or excess, the retinol treatment caused a substantial decrease in the concentration of plasma methionine of rats fed ad libitum. " 

These observations on the products and intermediates of methionine degradation in the transsulfuration pathway and the observation on S-methylcysteine toxicity suggest that excess retinol treatment mainly affected the initial steps of the transsulfuration pathway.

This is why i think straight methionine.  We have a natural way of doing this...and i honestly dont think we even need to worry about the homocysteine if this is the case.  Even so, adding TMG to this stack would recycle the homocysteine back into methionine anyway.  Im not so sure about the Glycine as much anymore...it could be accelerating methionine loss. Plus, we  would be getting some amounts of Glycine by adding the TMG.

Methionine
SAM-E
Taurine
TMG (betaine)  
B6 

And why Taurine is helpful:

[Edited link out]

[Edited link out]

On 1/9/2016 at 6:22 AM, yetanotheraccutanevictim said:

@guitarman01The guy said he has extensive experience with using it. I'd trust his word about oral being ineffective.

However, if you aren't going to insert it into your veins at all, I'd love to hear feedback on oral ingestion regardless.

How many mg did you buy? The boy cured of hypervitaminosis A via acute IV treatment was administered 7,500 mg daily for 4 days straight (30 g total). Pretty sure they hooked him up on a 24/hr drip. Also, the study doesn't say he did subcutaneous treatment.

Is there anyone else looking into using HP beta-cyclodextrin? Preferably, we could get a doctor to administer this to us.
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This is interesting. It even mentions the study I referenced:
[Edited link out]

[Edited link out]

Person receives cyclodextrin infusion:
[Edited link out]

Also, it will bind up that synthetic palmitate you took as well:
[Edited link out]

I bought 25 grams from that same source you posted from amazon hes on ebay as well. So I guess thats just about perfect. I would think we would be on our own with this. the dr would have to have concrete evidence im sure to go along with this type of treatment. I mean fda approves first ever cyclodextrin infusion? meaning extreme circumstances. the downside is not being monitored while you are doing this not knowing what was going on inside of you. I just cant justify it myself yet. but hey people shoot up heroin all the time right? its got to be safer then that.
we could at least monitor our heart rate, blood pressure, blood sugar?
any other company that makes cyclodextrin we could email for a second opinion on taking it orally? I mean dont they make a oral version of this drug mixed with accutane to make it more water soluble and less toxic? wouldnt it kind of be the same then just backwards minus the accutane

On 1/9/2016 at 8:00 AM, tryingtohelp2014 said:

[Edited link out]

"The most profound change in the concentration of plasma amino acids by excess retinol treatment was the decrease in the concentration of methionine. Regardless of the level of methionine in the diet, optimal or excess, the retinol treatment caused a substantial decrease in the concentration of plasma methionine of rats fed ad libitum. " 

These observations on the products and intermediates of methionine degradation in the transsulfuration pathway and the observation on S-methylcysteine toxicity suggest that excess retinol treatment mainly affected the initial steps of the transsulfuration pathway.

This is why i think straight methionine.  We have a natural way of doing this...and i honestly dont think we even need to worry about the homocysteine if this is the case.  Even so, adding TMG to this stack would recycle the homocysteine back into methionine anyway.  Im not so sure about the Glycine as much anymore...it could be accelerating methionine loss. Plus, we  would be getting some amounts of Glycine by adding the TMG.

Methionine
SAM-E
Taurine
TMG (betaine)  
B6 

And why Taurine is helpful:

[Edited link out]

 

[Edited link out]

If you guys may or may not remember, there was a doctor who posted a thread awhile back (January?) about methionine. Here is the text:

"I am a physician suffering from floaters. I have found good experience using inosital, choline and methionine 500 mg of each twice daily. This regimen is also discussed by Dr. Wright and Gaby who are nutritional experts. This process works by allowing the liver to clear fats. These three products are called lipotropic agents. I also use high dose enzyme supplements to obtain enzymes within the eye. Omega-3 fatty acids are also useful if your levels are low. I perform these tests at my clinic."

Andrew K. Messamore, M.D.
 

 

eye floaters are a major pain for me that have stuck with me for years now since taking high dose vitamin a thinking my vitamin a metabolism was messed up by accutane. I will def try this. thing is I was taking all the supplements from the "rescue cocktail" and one was giving me bad acid reflux. I need to figure out which one. I just cant deal with that. It gets into my throat. think b6 maybe gives me acid reflux too. another side from accutane I believe due to the dryness and inflammation,weak muscles? Im still waiting on my homocysteine test level result so at least id have a base to go off of and could get rechecked from time to time. what kind of dose methionine are you thinking would be safe/effective per day? and whats your reasoning? mainly that it would be safe.

59 minutes ago, guitarman01 said:

eye floaters are a major pain for me that have stuck with me for years now since taking high dose vitamin a thinking my vitamin a metabolism was messed up by accutane. I will def try this. thing is I was taking all the supplements from the "rescue cocktail" and one was giving me bad acid reflux. I need to figure out which one. I just cant deal with that. It gets into my throat. think b6 maybe gives me acid reflux too. another side from accutane I believe due to the dryness and inflammation,weak muscles? Im still waiting on my homocysteine test level result so at least id have a base to go off of and could get rechecked from time to time. what kind of dose methionine are you thinking would be safe/effective per day? and whats your reasoning? mainly that it would be safe.

Methionine is the top of the food chain. everything else comes from it. cysteine ,taurine SAM-E, ,choline etc. It can form everything, but the parts cant form the initial methionine. I think i can trace almost every single symptom on this board back to methionine. From allergies, depression, joint pain, tendon and muscle pain, dry skin, floaters, bile acid formation/cholestasis problems ... all kidney and liver dysfunction, elevated vitamin A in liver.

Plus i think the floaters are a collagen problem imo. its physical proof that your body isnt keeping the bonds together..its breaking down too fast.

The two KNOWN ways that acctuane is detoxified are methionine dependent.
Taurine
Glucuronic acid is a GAG is made from methionine. no methionine= no glucuronic acid

Fatty liver congested with whatever, is #1 by far the main culprit. thats why the guy tried patenting the solution.

Just dont know how much to take for how long. i dont know what is optimal for the quickest resolution.

1000mg Methionine (probably 2000mg soon)
800mg SAM-E (probably up to 1600 soon)
3000mg Taurine (probably 6000 in future)
1000mg TMG

and an extremely sulfur rich diet. onions,cauliflower,broccoli, with chicken.

There was also a blurb in one of the studies that said... retinoids are cleared much slower in obese people. fat loss is essential.

4 minutes ago, tryingtohelp2014 said:

Methionine is the top of the food chain. everything else comes from it. cysteine ,taurine SAM-E, ,choline etc. It can form everything, but the parts cant form the initial methionine. I think i can trace almost every single symptom on this board back to methionine. From allergies, joint pain, tendon and muscle pain, dry skin, floaters, bile/cholestasis ... all kidney and liver dysfunction, elevated vitamin A in liver.

Fatty liver congested with whatever, is #1 by far the main culprit. thats why the guy tried patenting the solution.

Just dont know how much to take.

1000mg Methionine (probably 2000mg soon)
800mg SAM-E (probably up to 1600 soon)
3000mg Taurine (probably 6000 in future)
1000mg TMG

we could get around 1000mg of methionine per day in diet alone so i would think it would have to be a considerable amount higher to make a difference
http://www.vitaminstuff.com/methionine.html
people with aids have low meth levels. study uses 6 grams per day?
was being used in parkinsons think they are old studies though

Methionine is essential for the formation of healthy collagen used to form skin, nails, and connective tissue, and helps reduce the level of inflammatory histamines in the body. People with conditions linked to excessive histamine production, such as arthritis and chronic allergies, may benefit from methioninesupplementation.
thats interesting

Here's the patent Tryingtohelp2014 is referring to:
https://www.google.com/patents/US4649040
"In accordance with the present invention any agent or compound which prevents the formation of fatty liver can be used to ameliorate the pathological or toxic effects of retinoids.Preferred agents known to prevent formation of fatty liver include biotin, chloline chloride, methionine, betaine, inositol and the like.These agents or compounds, hereinafter termed "rescuing agents", may be used either alone, in mixture or in combination with other agents or compounds including retinoids.

The most potent substance of the group was L-methionine, which at 1% concentration led to the rescue of 70% of the mice."

Thats right. thats why this doesnt make sense, unless

1. we need to take much more...a true theraputic dose.
2. Our diet never catches up. the 1000 we eat is needed to keep basic the functionsworking before it has excess to detoxify anything.

I hope with the additional sulfurs ... the SAM-E with the taurine and methionine will be the cocktail.

And the cyclodextrin literally "knocks" the vitamin A or retinol out of the liver/adipose tissue. thats why theres much more in serum than could be possibly due to the drug chelating everything. that would be the scary part, and i dont think its a good idea. we took the equivalent of millions of IUs of vitamin A.

just need to find a study/studies where high dose methionine was safe for a period of time and made sense ie. chronic deficiency

Is anyone willing to take a REALLY high dose of these nutrients for a couple days and see how you feel?

And everyone remember, that taurine + methionine is very important. That greatly enhances the effect

And sorry to go off topic but I was shocked at this:
"In the experiments described hereunder mice (C57 BL/6J-males) were used. A toxic dose of 13-trans retinoic acid, 500 mg/kg, was administered by an intraperitoneal injection of the suspension of the acid in physiological saline. This one time dose has several pathological effects in mice as described by Bolag, supra, and results in death of nearly all of the animals. Mice injected with retinoic acid were thereafter divided into the following groups: (a) control animals which received tap water to drink; (b) treated groups which, in place of tap water, were supplied with solutions of various rescuing agents in tap water."

Our dose may have been less, like 80mg, but it went on for MONTHS! If the average rat weighs about 300 g (0.3kg), the dose would be 150mg!
I took 10,800 mgs...

@guitarman01"Experiments were also conducted which established the non-toxicity of the rescuing agents mentioned herein."

1 hour ago, yetanotheraccutanevictim said:

Is anyone willing to take a REALLY high dose of these nutrients for a couple days and see how you feel?

And everyone remember, that taurine + methionine is very important. That greatly enhances the effect

And sorry to go off topic but I was shocked at this:
"In the experiments described hereunder mice (C57 BL/6J-males) were used. A toxic dose of 13-trans retinoic acid, 500 mg/kg, was administered by an intraperitoneal injection of the suspension of the acid in physiological saline. This one time dose has several pathological effects in mice as described by Bolag, supra, and results in death of nearly all of the animals. Mice injected with retinoic acid were thereafter divided into the following groups: (a) control animals which received tap water to drink; (b) treated groups which, in place of tap water, were supplied with solutions of various rescuing agents in tap water."

Our dose may have been less, like 80mg, but it went on for MONTHS! If the average rat weighs about 300 g (0.3kg), the dose would be 150mg!
I took 10,800 mgs...

i am willing to take high dose anything if it makes enough sense. So the bright side is we are not dead!
shit I was downing straight olive oil awhile back, I dont even remember why now

https://books.google.com/books?id=lo4IurHUYWcC&pg=PA187&lpg=PA187&dq=methionine+deficiency&source=bl&ots=5n5mw2b9uc&sig=egAyR7cbVwMz4agtL5hD940mU2U&hl=en&sa=X&ved=0ahUKEwjo9puCzZvKAhVL9GMKHf0hA1g4FBDoAQgmMAM#v=onepage&q=methionine%20deficiency&f=false
read that part about meth. anyway you look at it, just doesnt sound good in high doses. do we just skip meth and go to sam-e?

is there any benefit to meth alone? or is its sole beneficial purpose to make sam-e?
minus the whole part about it being at the top of the food chain

On 1/9/2016 at 9:30 AM, tryingtohelp2014 said:

Thats right. thats why this doesnt make sense, unless

1. we need to take much more...a true theraputic dose.
2. Our diet never catches up. the 1000 we eat is needed to keep basic the functionsworking before it has excess to detoxify anything.

I hope with the additional sulfurs ... the SAM-E with the taurine and methionine will be the cocktail.

And the cyclodextrin literally "knocks" the vitamin A or retinol out of the liver/adipose tissue. thats why theres much more in serum than could be possibly due to the drug chelating everything. that would be the scary part, and i dont think its a good idea. we took the equivalent of millions of IUs of vitamin A.

this anything?
[Edited link out]

On 1/9/2016 at 9:30 AM, tryingtohelp2014 said:

Thats right. thats why this doesnt make sense, unless

1. we need to take much more...a true theraputic dose.
2. Our diet never catches up. the 1000 we eat is needed to keep basic the functionsworking before it has excess to detoxify anything.

I hope with the additional sulfurs ... the SAM-E with the taurine and methionine will be the cocktail.

And the cyclodextrin literally "knocks" the vitamin A or retinol out of the liver/adipose tissue. thats why theres much more in serum than could be possibly due to the drug chelating everything. that would be the scary part, and i dont think its a good idea. we took the equivalent of millions of IUs of vitamin A.

this anything?
[Edited link out] nm probobly not

while looking at other processes in the liver that accutane could have f'd up have we also looked at b1,b6 and phosphatidylcholine?
particularly phosphatidylcholine. quick wiki. it is used with something similar to taurine to break down highly lipid drugs. can become deficient in alcoholic liver and must be supplemented

https://books.google.com/books?id=lo4IurHUYWcC&pg=PA187&lpg=PA187&dq=methionine+deficiency&source=bl&ots=5n5mw2b9uc&sig=egAyR7cbVwMz4agtL5hD940mU2U&hl=en&sa=X&ved=0ahUKEwjo9puCzZvKAhVL9GMKHf0hA1g4FBDoAQgmMAM#v=onepage&q=methionine%20deficiency&f=false
read this about phosphatidylcholine

Old study but states low blood and liver stores of vitamin c and Impaired synthesis of vitamin c in vitamin a deficiency and excess
https://books.google.com/books?id=4Excpge8Q2YC&pg=PA315&lpg=PA315&dq=ascorbic+acid+retinoids+study&source=bl&ots=6yJEOJH-ZO&sig=-3ZtMZrOITHs_8lAkzC3Ih9r2Iw&hl=en&sa=X&ved=0ahUKEwj0rPr_-ZvKAhVByGMKHVWmAHEQ6AEIQjAJ#v=onepage&q=ascorbic%20acid%20retinoids%20study&f=false

Was looking up methionine to order and came across this, what are your thoughts?
 

http://www.ncbi.nlm.nih.gov/pubmed/6957421

Negligible amounts of unchanged isotretinoin were excreted in urine, whereas 53 to 74 per cent of the dose was recovered as intact isotretinoin in the feces.

Has anyone managed to cure hair thinning issue? (5 months post accutane) If this has been discussed in detail can you please tell me approx what page is it on? Thanks

was just thinking. Are there any animal studies where their hair loss never recovered from accutane, vitamin a toxicity?

http://www.hormonesmatter.com/my-sons-gardasil-story-thiamine-deficiency/
heres something different. someone should get this blood test for the hell of it.
looks to cause alot of vague symptoms like our own.
anyone look at Benfotiamine , Allithiamine ,or just high dose plain thiamine like 300mgs a day?
http://pubs.niaaa.nih.gov/publications/arh27-2/134-142.htm

In the body, particularly high concentrations of thiamine are found in skeletal muscles and in the heart, liver, kidney, and brain (Singleton and Martin 2001). In the tissues, thiamine is required for the assembly and proper functioning of several enzymes that are important for the breakdown, or metabolism, of sugar molecules into other types of molecules (i.e., in carbohydrate catabolism). Proper functioning of these thiamineusing enzymes is required for numerous critical biochemical reactions in the body, including the synthesis of certain brain chemicals (i.e., neurotransmitters); production of the molecules making up the cells genetic material (i.e., nucleic acids); and production of fatty acids, steroids, and certain complex sugar molecules. In addition, inadequate functioning of the thiamineusing enzymes can interfere with the bodys defense against the damage (i.e., oxidative stress) caused by harmful, highly reactive oxygen molecules called free radicals. (For more information, see the section Thiamines Actions in the Cell.)

Because thiamine and the thiamineusing enzymes are present in all cells of the body, it would be plausible that inadequate thiamine affects all organ systems;

deficiencycan be caused by liver damage.

@vianelloYeah, accutane is primarily excreted out the biliary system in the bile. But a lot is reabsorbed before full excretion.

Does anyone here have poor dream recall? Zinc or B6 deficiency perhaps.. Maybe serotonin and thus melatonin deficiency as well due to poor methylation by lack of methionine.. I haven't remembered a single dream for about 2 years...

Also, does anyone here recall smelling ammonia in their urine throughout their accutane treatment?
What about now? Any ammonia smells, anyone? This would indicate transsulfuration pathway issues.

--

EDIT: If anyone here has their 23andme raw data, get the $30 report generated from mthfrsupport.com (sterling's app). It's the ABSOLUTE BEST one on the web for analyzing your data. It even comes with pathway charts... I have paid $50 for Nutrahacker and $5 for Promethease and I've done a Genetic Genie etc... Sterling's app is the top dog.
VERY helpful.

Another study linking retinoic acid degradation in the liver with ethanol:
(yet another "accutane being able to stored in the liver" link)
https://www.ncbi.nlm.nih.gov/pubmed/11208727

Stored in the liver..
Liver flushing and liver lipotropic nutrients are our cure

https://www.ncbi.nlm.nih.gov/pubmed/2730336

Pregnant hamsters were given a single oral dose (35 mumol/kg) of all-trans-retinoic acid, 13-cis-retinoic acid, all-trans-4-oxo-retinoic acid, 9-cis-retinal or all-trans-retinyl acetate during the early primitive streak stage of development. The radioactivity associated with the acidic retinoids was distributed to all tissues sampled (including placenta and fetus), with the largest accumulation in theliverand the least accumulation in fat. Radioactivity from 9-cis-retinal or retinyl acetate concentrated in theliverand lung. The all-trans-retinoic acid was oxidized in vivo to all-trans-4-oxo-retinoic acid and isomerized to 13-cis-retinoic acid: 13-cis-retinoic acid was oxidized to 13-cis-4-oxo-retinoic acid and isomerized to all-trans-retinoic acid. No parent 9-cis-retinal or retinyl acetate could be detected in maternal plasma. Plasma concentrations of the parent acidic retinoids reached their maxima within 60 min and then followed exponential decay. Of all the retinoids examined here, 13-cis-retinoic acid showed the largest area under the plasma curve, the slowest clearance and the longest elimination t1/2. Total plasma radioactivity, consisting of unidentified metabolites, remained elevated at 4 days after dosing. Maternal peak circulating concentrations of the parent retinoids, total radioactivity, plasma pharmacokinetic parameters or the total concentrations of residual radioactivity in fetal tissues could not be correlated with the differential teratogenic potencies of these retinoids.

By the way, accutane is isotretinoin or 13-cis-retinoic-acid which is converted into all-trans-retinoic acid in the body.

https://www.ncbi.nlm.nih.gov/pubmed/21946003
Retinoids (vitamin A) are known to be involved in many key biological functions in mammals, such as embryonic development, reproduction or vision. Besides standard vitamin A forms, freshwater fish tissues contain high levels of didehydroretinoids or vitamin A(2) forms. However, the tissuedistribution, metabolism and function of both standard and particularly the didehydroretinoids are still poorly known in fish. In this study, we have quantified the levels of retinoids, including retinol, retinaldehyde, retinyl palmitate and their corresponding didehydro forms, as well as the levels of the active polar retinoids all-trans-, 9-cis- and 13-cis-retinoicacidin distinct tissues of juvenile rainbow trout. Our results indicate that theliveris clearly the main retinoid storage tissue in juvenile rainbow trout. Didehydroretinoids were dominant over retinoids in all analyzed tissues with the exception of plasma. Additionally, significant differences among tissues were observed between retinoids and didehydroretinoids, such as differences in the ester profiles and the proportions between free and esterified forms, suggesting that mechanisms that favor the utilization or storage of one of the other groups of compounds might exist in fish. Our data also show the presence of polar retinoids in different tissues of fish at the fmol/g scale. Overall, this study clearly demonstrates the presence of tissue-specific patterns of accumulation of both polar and nonpolar retinoids in fish tissues. The biological relevance of these findings should be the focus of future studies.
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Sorry to keep beating this dead horse but some still don't believe isotretinoin can be in the body
https://www.ncbi.nlm.nih.gov/pubmed/10662603
The retro-retinoids 14-hydroxy-4,14-retro-retinol (14-HRR) and anhydroretinol (AR) are endogenous metabolites of retinol (Vitamin A). 14-HRR and retinol, but notretinoicacid, promote the proliferation of lymphocytes and fibroblasts when cultured in serum-free medium, whereas AR competitively inhibits these growth-supportive effects. Retinol andall-trans-retinoic acidare potent teratogens. This study shows the teratogenic potencies of 14-HRR and AR compared to retinol at a single gestational time. Also reported is the metabolism of these retinoids in nonpregnant mouseliver, the primary storage tissue of vitamin A, where many retinoids will be present at their highest concentration. Additionally, measurement of these metabolite concentrations was carried out in pregnant mouse plasma and embryos because they are the most relevant to teratology. Single intraperitoneal administration of 60 mg/kg of all-trans-retinol (retinol) to C57BL/6J mice at gestational day 7.5 produced a significant induction of eye and axial skeletal malformations. The equivalent dose of 14-HRR or AR induced a lower frequency of embryolethality and eye and axial skeletal malformations indicating that these retro-retinoids are less potent teratogens than retinol. Thedistributionof 14-HRR, AR, retinol, and their metabolites was determined in theliverat a single time point after retinoid administration. Two hours after 60 mg/kg of 14-HRR treatment, HRR esters are detected. Two hours after 600 mg/kg of AR treatment, 14-HRR is detected, suggesting that 14-HRR, a reported metabolite of retinol, can be biosynthesized from AR. In both cases, neitherretinoicacidnor retro-retinoid acidic metabolites were detected. Two hours after 60 mg/kg of retinol treatment, 14-HRR, 13,14-dihydroxyretinol (DHR), AR, andretinoicacidwere detected. A new endogenous retro-retinoid, to which the 4-hydro-5-hydroxy-anhydroretinol structure is proposed, was detected in allliverextracts.
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https://www.ncbi.nlm.nih.gov/pubmed/9923548
Results showed that 13-CRA was metabolized differently in various tissues, but concentrations of 13-CRA detected in tumor were in the range reported to be active in vitro.all-trans-Retinoic acid(ATRA) concentrations were about 5% of the 13-CRA concentrations detected in plasma, 68% of those found inliver, and 20% of those found in tumor.
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https://www.ncbi.nlm.nih.gov/pubmed/9299599
Of maternal tissues, peak 13-cis-RA concentrations were highest inliver. Total concentration of RA (13-cis-RA + 13-cis-4-oxoRA + all-trans-RA + all-trans-4-oxoRA) per gram of wet tissue was greatest in maternalliver, followed by that in lung, adipose tissue, muscle, kidney, and brain.
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And for those who are scared to ingest vitamin A or provitamin A:

--
https://www.ncbi.nlm.nih.gov/pubmed/6102031
Tissue levels of 13-cis-retinoicacid, although generally not as high as those in serum, decreased in a manner similar to that for serum. Levels ofall-trans-retinoic acidinliver, kidney, lung, brain, and small intestine were generally higher than those of serum throughout the period of observation. At 8 hr after injection of the mice, relatively high levels ofall-trans-retinoic acidremained in the brains, and detectable levels of 13-cis-retinoicacidpersisted in the lungs. N-Hydroxyethylretinamide also persisted in tissues for long periods of time, with tissue levels generally higher than those in serum. At 18 hr after injection of mice, relatively high levels of this compound were found in theliver, kidneys, and testes.
--

Is anyone able to pull up this study:

Effects ofretinoicacidon the mobilization of vitamin A from theliverin rats.

https://www.ncbi.nlm.nih.gov/pubmed/571461

Some stuff I threw together about vitamin A storage:
[Edited link out]
liver anatomy:
[Edited link out]

On 1/10/2016 at 10:16 AM, yetanotheraccutanevictim said:

Is anyone able to pull up this study:

Effects ofretinoicacidon the mobilization of vitamin A from theliverin rats.

https://www.ncbi.nlm.nih.gov/pubmed/571461

 

yep. here you go
[Edited link out]
idk whats a better scenario, if its still in our liver or not when it comes to trying to figure out what the hell went wrong. because obviously there are many, many people that take accutane that are fine. So how and why are we different?
ive had plenty of moments post accutane where I felt and looked great. So what was different at those points?
if it was toxicity that should slowly heal over time. why is it the opposite?, seems we get slowly worse. I felt great shortly after post tane. wouldnt toxicity be at its peak then?
What happens that is such a slow burn?

@yetanotheraccutanevictim

Thank you for all the research. Im not against the theory that "accutane" is "stored".
But none of the papers you mentioned, states that it is stored, it just shows where high concentrations of it and its metabolites can be found after ingestion.

"Growth and feed intake was somewhat reduced in rats receiving the highest level of all-trans retinoic acid. Liver analysis did not reveal fatty liver or alterations in phospholipid, cholesterol, or vitamin A content in any groups monitored "
http://www.ncbi.nlm.nih.gov/pubmed/7354404

Good little post on the liver detoxification system:
Shows all the pathways and nutrients involved
http://www.thepaleomom.com/2016/01/what-the-heck-does-our-liver-do-anyway-detoxification-explained.html

@vianelloWe may never have ABSOLUTE proof that it is in our bodies, still. I'd rather not assume that it's not and not take measures to get well. I know from others here who are still sick YEARS later that we may never get well if we don't target the accutane.