Acne.org Products
http://www.ncbi.nlm.nih.gov/pubmed/11595810
Read this!
intresting thread
On 12/20/2015 at 7:43 PM, Mike San said:Yep DHEA won't boost T, and also boosts E2. Im low on DHEA, but afraid to take as it boosted my E2. May take lower dose.
Arimidex to block conversion to E2 
On 12/21/2015 at 5:22 AM, Mike95 said:I found this forum by searching about acne and my symptoms. I never took Accutane but since I turned early 20 y/o I've been having similar symptoms mentioned in this thread for past few years. Thoughts repeat in my head, sometimes anxiety in my head gets so bad I get headaches. Social anxiety, nervous in public. I've become bad socially. In conversations I can never think of what to say and no one likes talking to me because it's so boring.
I told dr. about my problem and prescribed ssris. i tried several and it made things WORSE. ever since I took a ssri years ago ive felt like an old man and im in my 20s for crying out loud. i never recovered from the ssri. I am not lying when i say i feel 90 years old on some days. i feel like sleeping all day sometimes and i have no energy. Used to like working out, now i have no energy ever since taking ssri. I have been off ssris for 6 years and still have the effects of no energy even though i only tried them for 3 months.
ive tried tons of supplements, got lab tests, no help. Dr prescribing ssri just made symptoms worse. not to mention i got really bad acne at the same time and it is persistent. Dr. tried to convince me to go on accutane, but ive known someone in real life who said he had bad side effect from it.
I also have sexual problems and have not had sex in years. really low libido now. used to have high libido.i get no morning or night erections. I took a supplement called INOSITOL and i had my first morning erection in years and it was hard, but then it was soft the next day and and no i get no erections period.
The fact that i could get a hard erection on one day shows me that i dont have damage to my p. But why does it nor work properly? something is telling me that i have a brain problem and its not communicating with my body properly.
I know this is an ACCUTANE thread, but can anyone provide me help into the right direction, since these are many of the same symptoms? ACNE is another bad symptom i have in addition, so it is somewhat relevant. If you dont want me posting in this thread since i never took the drug, i can understand. but if someone can PM me with help, I would appreciate it. I want to back to feeling normal again. Thanks, Mike.
Test your testosterone, free tesosterone, dhea and DHT at your doctor. Also test SHBG and E2
If those are normal then you just have neurochemistry issues, which you would rather go to longecity forums to figure out.
SSRI probably just made your neurological problems worse. The brain is really weird and its state of health will make you feel like a 20 year old superhuman or a 90 year old sick guy even when your health is fine..
SSRI's can be a godsend or they can ruin your life.
Only suggestion i could have beside testing your hormones is to try these supplements: SAM-e, N-acetyl L-tyrosine, Inositol, 5htp (not when on an SSRI)
But research those supplements first..
Go to examine.com and read about stuff for depression..
-------
So ive been talking to [removed] on skype for a few hours on two seperate days now.. He is starting to understand why we have all these issues but he has no free time to research it because he is already busy with all the other stuff he does.
So i "partnered" up with him and ill research it as much as i can and he and i will discuss it and eventually figure out what works to treat this.
-----
Here have some science
Accutane, Methylation Block and Glycine N-Methyltransferase
1. "All-trans-Retinoic Acid Rapidly Induces Glycine N-methyltransferase in a Dose-Dependent Manner and Reduces Circulating Methionine and Homocysteine Levels in Rats, [Edited link out]
2. "Retinoic Acid and Glucocorticoid Treatment Induce Hepatic Glycine N-Methyltransferase and Lower Plasma Homocysteine Concentrations in Rats and Rat Hepatoma Cells," http://jn.nutrition.org/content/133/11/3392.full
3. "Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific," http://www.ncbi.nlm.nih.gov/pubmed/12054489
4. "Decreased plasma folate concentration in young and elderly healthy subjects after a short-term supplementation with isotretinoin," [Edited link out]
5. "Inhibition of glycine N-methyltransferase by folate derivatives: implications for regulation of methyl group metabolism," http://www.sciencedirect.com/science/article/pii/S0006291X85800061
6. "Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural ligand," http://www.jbc.org/content/264/16/9638.full.pdf
Accutane will cause gut inflammation, and death of hypothalamic and hippocampal tissue.
Isotretinoin's exact mechanism of action is unknown, but several studies have shown that isotretinoin induces apoptosis (cell death) in various cells in the body. Cell death may be instigated in the meibomian glands,[50][51] hypothalamic cells,[52] hippocampus cells[53][54] and”important for treatment of acne”in sebaceous gland cells.[55][56]
Several trials over inflammatory bowel disease claims have been held in the United States thus far, with many of them resulting in multimillion dollar judgments against the makers of isotretinoin.[76] In 2009 Roche decided to pull Accutane off the market, stating at the time that the move was related to market pressures and the high cost of defending Accutane lawsuits.[77]
It changes something With FoxO and increases Conversion of SAM to SAH + it makes some glycine enzyme overactive so u run out of it quicker or something
On 12/21/2015 at 9:12 AM, Relentless1k said:Here have some science
Tryingtohelp2014 has some good posts on that enzyme upregulation mechanism somewhere.
You mention that it changes something with Fox0
From one of my earlier posts:
" As I currently understand it,when we ingest 13-cis-retinoic acid (13CRA/accutane)it is isomerized to all-trans retinoic acid (ATRA)which has the capacity to bind to cis retinoic acid-binding proteins (CRABPs) which go on to activate nuclear retinoid receptors (RARs) to form RAR-RXR heterodimers which bind to DNA and initiatetransactivation of retinoid responsive elements (RAREs) which induce the teratogenicity within the nucleus of cells. This also leads to a deficiency of FoxO proteins via FoxO-mediated transcriptional regulation"
If you can, focus the research on methods of excretion: like glucuronidation. I'm pretty sure supplementing with calcium-d-glucarate & taurine & glycine will be a slam dunk. Also, Kombucha seems to be a natural source of glucaric acid. Worth experimentation.
Just a few posts I gathered about an accutane & liver congestion connection:
[Edited link out]
This forum user was cured through glucaric acid, kidney & liver flushes, and homeopathy (isotherapy specifically; yes, it's an effective method despite what you may hear from extremely conventional crowds): (not sure how I'd go about getting this done atm).
[Edited link out]
On 12/21/2015 at 9:52 AM, yetanotheraccutanevictim said:
This forum user was cured through glucaric acid, kidney & liver flushes, and homeopathy (isotherapy specifically; yes, it's an effective method despite what you may hear from extremely conventional crowds): (not sure how I'd go about getting this done atm).
[Edited link out]
You can orderGlucuronolactone from amazon.. its the same stuff they put in the energy drinks like taurine. Glucuronolactone breaks down intoglucuronic acid
http://www.amazon.com/LiveLong-Nutrition-Glucuronolactone-3-53-Ounce/dp/B003XW7P8C
52 minutes ago, tryingtohelp2014 said:You can orderGlucuronolactone from amazon.. its the same stuff they put in the energy drinks like taurine. Glucuronolactone breaks down intoglucuronic acid
http://www.amazon.com/LiveLong-Nutrition-Glucuronolactone-3-53-Ounce/dp/B003XW7P8C
Appreciate it. Noted. Will check it out in the future. Not sure how it compares to Calcium-D-Glucarate.
I've been taking Life Extension Calcium-D-Glucarate 200mg 1-3x/day.
On 12/21/2015 at 7:52 AM, yetanotheraccutanevictim said:Tryingtohelp2014 has some good posts on that enzyme upregulation mechanism somewhere.
You mention that it changes something with Fox0
From one of my earlier posts:
" As I currently understand it,when we ingest 13-cis-retinoic acid (13CRA/accutane)it is isomerized to all-trans retinoic acid (ATRA)which has the capacity to bind to cis retinoic acid-binding proteins (CRABPs) which go on to activate nuclear retinoid receptors (RARs) to form RAR-RXR heterodimers which bind to DNA and initiatetransactivation of retinoid responsive elements (RAREs) which induce the teratogenicity within the nucleus of cells. This also leads to a deficiency of FoxO proteins via FoxO-mediated transcriptional regulation"
If you can, focus the research on methods of excretion: like glucuronidation. I'm pretty sure supplementing with calcium-d-glucarate & taurine & glycine will be a slam dunk. Also, Kombucha seems to be a natural source of glucaric acid. Worth experimentation.
Just a few posts I gathered about an accutane & liver congestion connection:
[Edited link out]
This forum user was cured through glucaric acid, kidney & liver flushes, and homeopathy (isotherapy specifically; yes, it's an effective method despite what you may hear from extremely conventional crowds): (not sure how I'd go about getting this done atm).
[Edited link out]
Yeah, [removed] consumes tons of kombucha for many reasons, one of them being glucaric acid..
He went over that FoxO stuff that you sent there, but he couldnt really make sense of why it would play a huge role in making so many people so ill.. He thinks the main issue lies in the damage it did to the brain and nervous systems.
If we fix our guts, "clean our livers", have all the nutrients and a diet that is anti inflammatory etc, have flawless hormone levelsand also take some other supps based on our genetics etc, and we are still not nowhere near where we used to be pre accutane, then i think brain and nervous system damage is the most likely thing going on as well..
I will dedicate the rest of my lifeto researching accutanes effects, possible solutions and also make notes on what works and what doesnt work for me. I have a big budget soon so i will test everything that i think is useful to test. Currently im not studying or working and have no obligations except to spend time with my girlfriend, so i will work full time on accutane. BUT KEEP IN MIND I AM SICK AND I CAN ONLY MUSTER UP SO MUCH STRENGTH PER DAY TO WORK ON THIS. Some days i wont be able to work on it at all.
Im creating a blog and i will also do video blogs to document this. I wont post the videos or anything but if i ever figure out the solution i will have my journey to show both in written and visual format..
I doubt this thread will last forever.
At least the people who are heavily involved in trying to figure this stuff out, i think we should "team up" and have a group chat in some program. It could be anonymous if you dont want to involve your real life identity into this.
The people who are just looking for advice dont need to do this, im only interested in cooperating with people who actually do extensive research and self experimentation + go to doctors + get proper blood tests, genetic tests etc.. And the ones who are willing to do what it takes.
I'm leaning towards the brain as well. And the genetic transcription process. It's the only way these effects can last as long as they do. It also helps explain why doctors pull up healthy blood work and hormone panels on us, minus a few people on here with some low readings.
[Edited link out]
extensive study of the role or retinoid signaling in the adult brain.
in neuronal cells RA regulates the expression and activity of tyrosine hydroxylase and dopamine b hydroxylase (the enzymes that synthesize dopamine) and the dopamine D2 receptor (Table 2). Such observations have given rise to the idea that retinoid signalling may be an important influence on dopaminergic function and dopaminergic signalling in the adult brain.
There is something I feel askew with my dopamine signalling, so that does make sense. Then again, I have been on SSRIS (which lower dopamine) so its tough to say if its from Accutane or SSRI, but the main issues started during and after Accutane. I had been on SSRIs for years before with no issues there.
One should considersome dopaminergic medications if experiencinglow mood in combination with low sex drive and normal hormone levels. All taken in much lower doses than given to Parkinsons patients and safe. Ie L-Dopa with Carbidopa , Cabergoline, Selegiline (also an approved antidepressant).
I've tried L-dopa twice andboth times lead to a great enhancementof mood, appetite, and sex drive. Unfortunately, I had to taper off it was causing me some insomnia, but no other side effects. Then again, I am very prone to insomnia, so you may be more lucky.
Im now going to try cabergoline soon.
Itried supplements such as tyrosine, mucuna pruriens, etc and felt nothing.
Hello everyone,
I've been reading the posts in this thread for a very long time and I'm sure a lot of sufferers do the same... they just read and try to find anything useful here which may help them to find a way out of this hell in which Roche has put us all in. But I am sure that we all have to work together and form a big countermovement to the pharma-lobbyists to have a chance against them. Just reading here and complaining about the miserable state of health we're all in is not enough, I would like to encourage everyone who's just READING here to participate at the discussions, even if they feel exhausted and lack energy... we all have to combine our efforts in order to advance!
A short summary of what I experienced after Accutane: Took it three times (unfortunately), with 16, 17 and 19-20. Yes, 3 times, I'm dumb...
The effects are devastating: Lack of energy, sometimes very sleepy, very bad immune system (constantly getting ill, often with fever), brain fog, ED (I'm not firing blanks though, thank God... I have kids! 
), depression, mood changes, nausea, always rheumy, skinny (can't put on weight, it's just impossible). The list goes on and on but the symptoms are well-known here.
What is making me kinda worried is the very bad immune system I've got. In the past few years, I had some weird and long-lasting health issues, the worst one was a very, very bad Stomatitis which was damn painful... couldn't eat or drink anything and the mouth was filled with canker sores everywhere... I didn't count them, they were also on the tongue.... but it were many, I guess about 30? Whatever, in the end, it was so bad that I had to go to the hospital as I lost so much weight... Doctors there were surprised to see a young man in such a bad shape and with Stomatitis in his late twenties... (normally, it's something a kid gets) --> They were worried I have AIDS (which I have not, of course) as they just couldn't understand how bad the immune system could be for my relatively young age. Of course, the test turned out negative.
I have made a blood test recently though and to my surprise, neither DHEAS nor testosterone are low!
My Vitamin D and selenium-levels are abysmal, though. I've read in past posts that some people here have low Vitamin D so I'm one more to have the same issue, apparently.
I guess that Vitamin D levels are fucked up by the excessive levels of "Vitamin A" (artificial Vit. A....) we've put in our body. Does anyone of you know how much Vitamin D and Selenium one should take per day after having been "Accutained"?
What things should I also test? --> So far, I have tested Vitamin A/B12/D3/E, Calcium, Selenium, DHEAS, Testosterone. Any suggestions?
Thanks to everyone here...And don't lose hope! One day, the truth will be revealed to the masses...
HumbleBee
25 minutes ago, HARMaceutic said:Hello everyone,
I've been reading the posts in this thread for a very long time and I'm sure a lot of sufferers do the same... they just read and try to find anything useful here which may help them to find a way out of this hell in which Roche has put us all in. But I am sure that we all have to work together and form a big countermovement to the pharma-lobbyists to have a chance against them. Just reading here and complaining about the miserable state of health we're all in is not enough, I would like to encourage everyone who's just READING here to participate at the discussions, even if they feel exhausted and lack energy... we all have to combine our efforts in order to advance!
A short summary of what I experienced after Accutane: Took it three times (unfortunately), with 16, 17 and 19-20. Yes, 3 times, I'm dumb...
The effects are devastating: Lack of energy, sometimes very sleepy, very bad immune system (constantly getting ill, often with fever), brain fog, ED (I'm not firing blanks though, thank God... I have kids!
What is making me kinda worried is the very bad immune system I've got. In the past few years, I had some weird and long-lasting health issues, the worst one was a very, very bad Stomatitis which was damn painful... couldn't eat or drink anything and the mouth was filled with canker sores everywhere... I didn't count them, they were also on the tongue.... but it were many, I guess about 30? Whatever, in the end, it was so bad that I had to go to the hospital as I lost so much weight... Doctors there were surprised to see a young man in such a bad shape and with Stomatitis in his late twenties... (normally, it's something a kid gets) --> They were worried I have AIDS (which I have not, of course) as they just couldn't understand how bad the immune system could be for my relatively young age. Of course, the test turned out negative.
I have made a blood test recently though and to my surprise, neither DHEAS nor testosterone are low!
My Vitamin D and selenium-levels are abysmal, though. I've read in past posts that some people here have low Vitamin D so I'm one more to have the same issue, apparently.
I guess that Vitamin D levels are fucked up by the excessive levels of "Vitamin A" (artificial Vit. A....) we've put in our body. Does anyone of you know how much Vitamin D and Selenium one should take per day after having been "Accutained"?
What things should I also test? --> So far, I have tested Vitamin A/B12/D3/E, Calcium, Selenium, DHEAS, Testosterone. Any suggestions?
Thanks to everyone here...And don't lose hope! One day, the truth will be revealed to the masses...
HumbleBee
Take 10,000iu vit D every day for two weeks then get blood checked again
don't forget magnesium, k2 and b complex
will fix some of your probs but not all, but it's a start!
29 minutes ago, HARMaceutic said:
What is making me kinda worried is the very bad immune system I've got. In the past few years, I had some weird and long-lasting health issues, the worst one was a very, very bad Stomatitis which was damn painful... couldn't eat or drink anything and the mouth was filled with canker sores everywhere... I didn't count them, they were also on the tongue.... but it were many, I guess about 30? Whatever, in the end, it was so bad that I had to go to the hospital as I lost so much weight... Doctors there were surprised to see a young man in such a bad shape and with Stomatitis in his late twenties... (normally, it's something a kid gets) --> They were worried I have AIDS (which I have not, of course) as they just couldn't understand how bad the immune system could be for my relatively young age. Of course, the test turned out negative.
I have made a blood test recently though and to my surprise, neither DHEAS nor testosterone are low!
M
Look at the two ingredients for stomatitis in this gel?!
http://www.bmgpharma.com/images/prodotti/cst/gelX%20Version%205%20June%202014.pdf
1 hour ago, HARMaceutic said:Hello everyone, *symptoms explained*
HumbleBee
I would be VERY cautious with vit D supplementation. If you think about it, it's essentially like taking accutane but just vit D instead of vit A.
Watch Chris Masterjohn's Paradox video on youtube before supplementing so you understand mechanisms of action.
I would recommend getting all your D from sunlight alone. A good tip is to be cautious about supplementing with things that you can produce endogenously.
Also, I have a very weak immune system as well. According to 2 $300 spectracell tests, my immune system (21 yrs old) is that of an 80 yr old.. My WBCs are chronically low and my neutrophils are low as well. It also destroyed my platelets. They stay at around 125 permanently.
Take mucilaginous herbs like aloe vera & slippery elm bark, l-glutamine (preferably from loads of cabbage juice freshly squeezed), and high-dose vit C.
TransferPoint's 1, 3-D glucan and this one by this Dr. arethe best for immune support.
MycoFormulas Immune Defense is a blend of mushrooms which is great as well.
Also, astragalus, cordyceps, and rhodiola are also fantastic. Very safe.
If you could apply just a few of the above, your immune system would be 10x better.
I've found blending with a vitamix & using a juicer also invaluable in my recovery. My digestion is very poor so having something predigest everything is fantastic. If you are VERY sick, you could even blend ALL your food just for a few days (yes, including meats) as well as take pancreatic enzymes & betaine hcl with pepsin. Digestive bitters are also effective for stimulating gastric juices.
Thanks for sharing your story. Truly hope you don't have to suffer anymore.
Riboflavin is a component of theco-enzymesflavin mononucleotide (FMN) and flavin adenine di-nucleotide (FAD)
ThecoenzymesFMN and FAD are play a catalytic role in redox reactions, such as the conversion ofretinolto the active metabolite retinoic acid.
- FAD is required to convertretinol(vitamin A) to retinoic acid via cytosolicretinal dehydrogenase
IF this applied to possible stored accutane or trans 13 retinoic acid that was stored similar to vitamin a, then this is how you convert it and mobilize it.
Hey guys,
i've been browsing this board and the allthingsmale board for some time now, but didn't find where i was looking for so i'm just going to ask directly.
Currently i am 19 years old. I took accutane (40mg/day) for only three weeks and noticed my libido and ability to have erectionsdiminishing after two weeks. After researching a little i immediately quit the drug after the 20th day mark.
Now, 6 months later i have seen little recovery and finally decided to consult a doctor. (Haven't had the appointment yet, afraid doctor will tell me its all psychological).
My question is, has anyone seen improvement if little improvement was made the first 6 months?
I'm getting more and more pessimistic about it, and i'm afraid i will never experience a regular sexlife (since i'm still a virgin).
I have been turned on a few times, and also have had solid erections a few times, so i can't believe my dick is phisically broken. (though being horny only about 8 times in 6 months is totally abnormal for a 19 year old)
I just hope my T levels turn out to be low, and i can get things going again with TRT. Which leads me to my next question:
Did any of you hear about guys who's situation improved when on TRT after accutane?
Is there any hope or am i screwed for life? Are there other treatments/tests that have worked for people thati can ask my doctor for?
Btw sorry incase i made any spelling or grammatic errors, English is not my native language.
Any response would be greatly appreciated
Hi everyone.
It's been a while since I even thought about this forum, but someone commented on one of my videos today and it mentioned it.
It's crazy that this post is coming up to 1 million views.
I hope you are doing okay. I know that you're probably not and that you feel frustrated and lackhope that things will ever be good again. And I'm sorry that you have had to go through this.
Maybe a few of you watch my videos ({LINK REMOVED}) so will already know how I am doing, but for those who aren't aware, I am still pretty up-and-down. I am doing the best I can with what I have learned, but life is still very difficult for me at times, and I still am figuring out things for myself.
Some people message me and say this drug changed the very core of their being. They tell me they were never like this. And I think back to what I was like before this drug. I think I was always going to be this way, to a degree. I was always shy and - in retrospect - I can see I was an introvert and very sensitive from the get-go. I was always a worried child, prone to overthinking and dwelling on my mistakes. With this kind of personality, I am prone to struggling with society and its expectations of me. I'm supposed to be outgoing, funny, happy and enthusiastic, right? I am still trying to find my place in this World.
It has been difficult for me to admit, because I'm still certain this drug triggered depression and anxiety in me - as well as some health problems, like fatigue, but I know that I would have been this way without the drug. And frankly, there is no use in thinking what could have been.
And so, after 10 years of this (scary to think it has been so long), all I can really tell you is... I'm still here, and I'm okay.
Sometimes I really struggle and at times my mind goes to very dark places - meaning I contemplate suicide and feel unable to cope with life. And yet, I have had so many terrible days that I know I am capable of surviving. I struggle more during the Winter months... I can't get away and escape into nature for hours by myself. But I am better than I once was. And for those who think their brain was destroyed, somehow, by Accutane - know that depression and anxiety are very common. It is our environment that can trigger this. It isn't just the drug, and sometimes my brain works just fine.
It all comes with time and understanding. I guess I just reached a point where I was sick of wasting my money and energy and getting no answers. Most of you are still in the trap of trying to force something to happen. I haven't read the recent posts here, so I don't really know what your topic of conversation is, but I have been there too. I have tried to become my own doctor, a scientist and investigator. I'm still none the wiser. A lot of this makes absolutely no sense. And so, the deeper you swim (metaphorically speaking), the darker it gets and the more overwhelmed you feel. If you don't come up for air (take your focus off these problems), you will eventually drown (let this overcome you).
My advice, for what it's worth, is to give up searching for the answers. Because they remain forever out of reach, and your life will pass you by if you carry on like this.
I feel like I wasted a lot of time - where I could have been focusing on a career, or my interests. I used to read horror stories for hours after work, and I would go to sleep in a state of anxiety. Is it any wonder that healing didn't occur?
I strongly believe our minds play the biggest role in this. If you lose that, you lose everything.
I don't come to you from a place of superiority or judgement. I am no better or worse than any of you here. I've just been on this journey longer than some of you and, with time, I haverealised some things.
After trying so many supplements, I now take none. I don't follow a specific diet - I just try and eat healthy for the most part and stay clear of things like alcohol and caffeine, because they mess with me like woahhh. I recently found out I was a HSP (Highly Sensitive Person) and explains why I feel so on edge, overthink and get drained from life. It's important to understand your personality and needs.
I need time to myself and in peaceful solitude, or I become snappy and not a very pleasant person.
If you want to, you can read my blog, here:{LINK REMOVED}
- All the best,
Stefan.
Good to hear from you Indigo.Manythanks for starting this thread, andspeaking out like you did on youtube, and that television show. But, it sounds as if you've reached a point of coping with your side effects, and that is ok, it's part of the healing process, but make no mistake about it, this drug does havethe ability to induce depression whether directly or indirectly in someindividuals.You of all people should know that. I'm surprised you've changed your stance as you were one of the ones quite severely affected.Unfortunately, it's a very complex subject and we are not sure at the moment if genetics plays apart, but the evidence is right there in the medical journals, the hippocampal degeneration in mice is a real scientific study. Now, it is a rare side effect of retinoid toxicity, but a side effect nonetheless, and many of us here areliving proof. Personally, my symptoms are not as strong as yours (i only took isotretinoinfor 1 month), but the lethargy, boredom, apathy is all present. A complete 180to the person prior Accutane. I am just now realizing that this issue may not be a hormonal one (as i previously thought) but rather neurological clinical symptoms of depression. Nevertheless, I am more focused on my signs that I can prove,rather than my symptoms,such as my intracranial hypertension, tendonitis & arthritis, and night blindness.
So, I think at the moment most of usare focused more so on the direct physiological effects (tendonitis, IBS, ed etc.)
We are working on identifying the mechanisms of action. Even if there is no cure, and if our telomereshave indeed been shortened, at least we'll know how it all happened. It's an impossible taskwithout formal medical schooling.Although, we do have a bit of an advantage sincewe have thetemplate of ourselves to use to see where or what went wrong in our systems post treatment and what if any chemical stimulates us back to pretreatment ideal homeostasis.
It would be good to have you back on board Indigo, as you make the perfect candidate to be one of our representativesandthe face of our movement.
ok know ive been all over the place but what about vitamin b5?
Deficiency symptoms include disorders of the nervous, gastrointestinal, and immune systems, reduced growth rate, decreased food intake, skin lesions and changes in hair coat, and alterations in lipid and carbohydrate metabolism.also loss of hair color and sensitivity to insulin. deficiency is ultra rare but maybe a mutation of how its processed?
impaired energy production, due to low CoA levels, which could cause symptoms of irritability,fatigue, andapathy.[13]Acetylcholine synthesis is also impaired; therefore, neurological symptoms can also appear in deficiency;[20]they include numbness,paresthesia, and muscle cramps.[20]Deficiency in pantothenic acid can also causehypoglycemia, or an increased sensitivity toinsulin.[13]Insulin receptors are acylated with palmitic acid when they do not want to bind with insulin.[22]Therefore, more insulin will bind to receptors when acylation decreases, causing hypoglycemia.[12]Additional symptoms could include restlessness, malaise, sleep disturbances, nausea, vomiting, and abdominal cramps.[20]In a few rare circumstances, more serious (but reversible) conditions have been seen, such asadrenalinsufficiency andhepatic encephalopathy.
2 hours ago, guitarman01 said:ok know ive been all over the place but what about vitamin b5?
Deficiency symptoms include disorders of the nervous, gastrointestinal, and immune systems, reduced growth rate, decreased food intake, skin lesions and changes in hair coat, and alterations in lipid and carbohydrate metabolism.also loss of hair color and sensitivity to insulin. deficiency is ultra rare but maybe a mutation of how its processed?
impaired energy production, due to low CoA levels, which could cause symptoms of irritability,fatigue, andapathy.[13]Acetylcholine synthesis is also impaired; therefore, neurological symptoms can also appear in deficiency;[20]they include numbness,paresthesia, and muscle cramps.[20]Deficiency in pantothenic acid can also causehypoglycemia, or an increased sensitivity toinsulin.[13]Insulin receptors are acylated with palmitic acid when they do not want to bind with insulin.[22]Therefore, more insulin will bind to receptors when acylation decreases, causing hypoglycemia.[12]Additional symptoms could include restlessness, malaise, sleep disturbances, nausea, vomiting, and abdominal cramps.[20]In a few rare circumstances, more serious (but reversible) conditions have been seen, such asadrenalinsufficiency andhepatic encephalopathy.
Great post but like everything post accutane even if we are deficient in b5 what are we to do about it??? Nothing works....
It's like the girl who posted about getting a hair mineral analysis - great, even if it comes back saying too much copper or something, what then???
It's my belief that many of us now suffer brain damage from roaccutane- the pressure in the head, the foginess, light sensitivity, depression etc - it's messed up something that at this stage can't be fixed just through taking supplements - that's my experience anyway.
stay strong folks - hopefully 2016 brings outmore truth and much less corruption in all our lives!!!
4 hours ago, TrueJustice said:
Great post but like everything post accutane even if we are deficient in b5 what are we to do about it??? Nothing works....
It's like the girl who posted about getting a hair mineral analysis - great, even if it comes back saying too much copper or something, what then???
It's my belief that many of us now suffer brain damage from roaccutane- the pressure in the head, the foginess, light sensitivity, depression etc - it's messed up something that at this stage can't be fixed just through taking supplements - that's my experience anyway.
stay strong folks - hopefully 2016 brings outmore truth and much less corruption in all our lives!!!
I might have to disagree with you on your statement about brain damage. Vitamin D cured me of brain fog and fatigue. It was only when I took too much and was too lazy to get my bloods checked, my vit D levels went skyrocketing to something like 375 nmol/L.
i experienced fatigue again but not the brain fog. I must have also knocked something out of balance in my body.
that was 7 months ago, got my blood work done again and my 25OH vit Dis at 81nmol/L
These days I only get tired a fewof hours after eating. I'm leaning more towards the gut.
55 minutes ago, trantran83333 said:
I might have to disagree with you on your statement about brain damage. Vitamin D cured me of brain fog and fatigue. It was only when I took too much and was too lazy to get my bloods checked, my vit D levels went skyrocketing to something like 375 nmol/L.
i experienced fatigue again but not the brain fog. I must have also knocked something out of balance in my body.
that was 7 months ago, got my blood work done again and my 25OH vit Dis at 81nmol/L
These days I only get tired a fewof hours after eating. I'm leaning more towards the gut.
I'm glad supplementing Vit D worked for you. I thought taking too much of it is quite dangerous - I could be wrong though!?
i live in Australia so I'd like to think I get my fair share of Vid D.
I did read once that to get rid of too much Vit A you should take Vit E....I tried this though and it didn't work for me.
The major problem post accutane is that you have to work on all problems similataneaosly - one minute it's a brain problem/ hormonal,next thing it's the gut, then it's the joints after that it's a hair problem and then an eye problem....the list goes on.
then it's a skin issue - mine is really dry but I sweat just brushing my teeth these days.....it never ends.
42 minutes ago, TrueJustice said:
I'm glad supplementing Vit D worked for you. I thought taking too much of it is quite dangerous - I could be wrong though!?
i live in Australia so I'd like to think I get my fair share of Vid D.
I did read once that to get rid of too much Vit A you should take Vit E....I tried this though and it didn't work for me.
The major problem post accutane is that you have to work on all problems similataneaosly - one minute it's a brain problem/ hormonal,next thing it's the gut, then it's the joints after that it's a hair problem and then an eye problem....the list goes on.
then it's a skin issue - mine is really dry but I sweat just brushing my teeth these days.....it never ends.
correct me if I'm wrong but doesn't vit A lower your vit D levels?
anyways I didn't take vit D for brain fog or fatigue. I took it for recurrent sinus infections and everyday blocked nose. I had to sleep sitting up at night, that's the only way I could breath.
back then I didn't know it was tane causing it, but sinus,blocked nose, fatigue and brain fog went away. because my D levels were so high and I must have knocked something out of balance and it gave me tinnitus. I'm guessing it's all about balance, that's why I want to get a hair test. I want professional advice, I'm not doing very well being my own doctor.
Im also from Australia,
merry Christmas to you and everyone here, may 2016 be good to everybody. I hope everyone will feel better soon