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1 hour ago, Mike San said:Thanks I didnt know that about ALA and I do a lot of reading usually. I used to take it for anti oxidant and nutrient partitioning effects if you take a large sugary meal. I don't have mercury toxicity that I know of and never had amalgams, but don't want heavy metals being moved around !
I dont know how big of an issue that is.But i dont think ALA is that important for healing either so it might be better to skip it. But its a wonderful supplement for other reasons. Resveratrol and berberine should be more than enough to handle big meals, if you want to try other things.
My insulin resistance stack / gain insulin sensitivity stack: Transresveratrol, berberine, inositol, d-chiro inositol and oxaloacetate. (Assuming you already get all the nutrients like d3, chromium, magnesium etc that helps a lot with insulin sensitivity)
1 hour ago, macleod said:That's quite interesting Relentless. I too have had an instance of what only can be described as temporary alcohol withdrawl to a mild serotonin like syndrome one night when combining about 375ml of alcohol, and a standard dose of motrin PM, which has in it anantihistamine, before bed. It wasn't until the next morning and about 12 hours later. I've replicated similar symptoms only once before through just alcohol consumption, but it was a far larger copious amount throughout a full 2 days, and it wasn't as intense, but was identical in that it was again 12 hours after cessation of ealcohol, that created mild DT alcohol withdrawl like symptoms. I'm thinking the anti histamine in the Motrim PM antagonized something. Again, Ethanol has been my crutch all these years as it is the only drug thathas a positive effect towardsmy dopamine. Not even powerful prescription opiod pain killers bring me pleasure, rather a feeling of groginess and spaced out excitability.I've tried several pharmaceutical drugspost tane that I used to quite enjoy pre tane and I can tell you something is definitely off chemically or metabolically in us.
I dont think alcohol + anti histamines can cause serotonin syndrome? The reason why i said SSRI + aminos cause that is because well SSRI increase serotoning and prevent the loss of it, and aminos can directly turn to serotonin if they cross the BBB, or thru another mechanism. SAM-e also creates serotonin through increasing methylation.
Maybe you just had alcohol sides?
Also can someone tell me why fish oil is bad after accutane? Is it because of vitamin A or due to blood thinning or some other reason?
I cant say i have a negative effect from supplementing it or eating fish
http://www.ncbi.nlm.nih.gov/pubmed/18823877
Maybe all SSRI's work in the same/similar way
FoxO1 is like an antagonist of androgen receptors. And FoxO3 is a main inducer of FoxO1. Both lowered with these drugs! This could have good results on our bodies.
This thread is offically doomed. Hormone injections?!?Holy shit have fun with THAT. PS suppliments area wasteeeee of your time and money, and so are all these tests and studying.
Lets talk food.
Whoever mentioned oysters is right on a winner. I had NEVER eaten an oyster, until yesterday when i ate about a dozen. They are weird! But as weird and gross as they look they are kind of addicting and tasty. Id been fasting since friday morning until yesterday sunday afternoon i broke it eating those oysters, and also, ate about a quarter of a tunafish. Good god i feel sharp and healthy today.
What should i eat next? (Probably eating today)
Oysters are great, they contain zinc and other good things.But I think that if even supplements fail, only food is not enough.
What do you mean by feeling healthy, I'm hapy for you maybe youare not messed up like others. Everybody is different. And sure if you are deficient in zinc oysters are great!
57 minutes ago, AlanTookAccutaneWow said:This thread is offically doomed. Hormone injections?!?Holy shit have fun with THAT. PS suppliments area wasteeeee of your time and money, and so are all these tests and studying.
Lets talk food.
Whoever mentioned oysters is right on a winner. I had NEVER eaten an oyster, until yesterday when i ate about a dozen. They are weird! But as weird and gross as they look they are kind of addicting and tasty. Id been fasting since friday morning until yesterday sunday afternoon i broke it eating those oysters, and also, ate about a quarter of a tunafish. Good god i feel sharp and healthy today.
What should i eat next? (Probably eating today)
Hormone injections are quite a normal thing in medicine. I believe any male over 35 should be on TRT. And if you can prove your hormones are low and you fail at restoring them, then injections/supplementation/replacement of those hormones is the only way to be healthy in that regard.
Supplements are often far more powerful than food. Or just more convenient. Resveratrol = several thousand grapes, NAD = several hundred glasses of milk, PQQ = a boatload of green tea
Etc. Lets say you cant handle blueberries or cocoa, you could still supplement extracted compounds from them.
Food is basic, its fundamental. Once your diet is perfect the only way to get further results is by adding in compounds/nutrients that you dont get from food.
Oysters are nothing special.
Fasting is not magic, and not sustainable.
Its like thinking ketosis will be a cure, no. Its only useful for certain reasons. Fasting is wonderful but also not a cure. COMBINING EVERYTHING THAT WORKS = CLOSEST TO A CURE. This means: Foods, supps, drugs, technology, lifestyle (exercise, sauna, meditation etc) and whatever else you can think of to add. Combine everything is far superior to only focusing on one area. Supplements are useless if your diet is shit.
The body needs all the micro and macro nutrients, EPA/DHA, some omega 6 and a certain amount of glucose daily if not in ketosis. The rest is just enhancing it. Blueberries are not required to live, but they can enhance your life. Eating 2 foods + 20 supps can be better than eating 22 different foods. It depends on the total intake of useful compounds daily, not really where they come from. (Dont take this out of context)
Stop focusing too narrowly on one area and open your mind. Food is the fundament but not the end all be all. Its just step one. Well drinking water is likely step one but you get the point. Also think of how to improve water. Filter it, distill it, get a molecular hydrogen machine, shine infrared on it, add minerals to it, increase the EZ of it.
Add. Add. Add. Until you are healthy. Or until you die trying.
When you have no nutrient deficiencies and get high quality protein, carbs and essential fats daily with enough calories to maintain your weight (if you are normal weight), and feel normal/perfect, then dont supplement if you dont want to. But if you are sick then even the most perfect diet may never fix you.
Plus even a healthy person with a perfect diet could still be better adding in all the things i mentioned
Your level of thinking is far inferior to others here in the thread if you really believe it doesnt go deeper than food.
But yes get food done right first. Then get your lifestyle in order. (or if you are too sick to workout and go to a sauna etc add this later),Then start with supps. Then with technology. (LLLT, ICES/PEMF, Infrared, sauna, light therapy etc) Then drugs/medicines if all else fails/if you believe this can really improve your life.
8 hours ago, Relentless1k said:I dont think alcohol + anti histamines can cause serotonin syndrome? The reason why i said SSRI + aminos cause that is because well SSRI increase serotoning and prevent the loss of it, and aminos can directly turn to serotonin if they cross the BBB, or thru another mechanism. SAM-e also creates serotonin through increasing methylation.
Well the ethanol is a CNS depressant and antihistamines are serotonergic, so I do believe it was a rudimentary concoction that produced temporary serotonin like syndrome symptoms, combined with withdrawal like effects.
In any case, the point being that I believe the chemical decomposition in some of us are askew, in that we do not tolerate foreign substances well anymore like a normal person does, and as we once used to prior to Accutane, whether prescription or over the counter. And my worse fear is that when and if we do need treatment, we either wont respond at all or respond adversely to some pharmaceuticals. In the aspect of pharmaceutical and chemical, rather than food, I feel as if my metabolism (don't know if this is a good example), that is the process that we break down compounds, is off. And, I am pretty sure I'm not the only one, as another member on here mentioned her experience with an ADHD medication before and after accutane was completely different. I think this is why we are forced to lean towards naturalist and holistic organic way of living, we really don't have a choice unless we want adverse effects.
4 hours ago, AlanTookAccutaneWow said:This thread is offically doomed. Hormone injections?!?Holy shit have fun with THAT. PS suppliments area wasteeeee of your time and money, and so are all these tests and studying.
Lets talk food.
Whoever mentioned oysters is right on a winner. I had NEVER eaten an oyster, until yesterday when i ate about a dozen. They are weird! But as weird and gross as they look they are kind of addicting and tasty. Id been fasting since friday morning until yesterday sunday afternoon i broke it eating those oysters, and also, ate about a quarter of a tunafish. Good god i feel sharp and healthy today.
What should i eat next? (Probably eating today)
Thats great news!
Try all seafood, make sure they're ocean caught not farmed ones. I like barramundi and salmon. I should really go get some more oysters. Haven't had any for like 2 weeks. Getting withdrawal symptoms lol.
Have you tried probiotics also? Make sure to take them before bedtime. I heard it's better that way so to let them grow overnight.
Thats if u have gut problems like I do. The gut is also very important for healing
4 hours ago, macleod said:
Well the ethanol is a CNS depressant and antihistamines are serotonergic, so I do believe it was a rudimentary concoction that produced temporary serotonin like syndrome symptoms, combined with withdrawal like effects.
In any case, the point being that I believe the chemical decomposition in some of us are askew, in that we do not tolerate foreign substances well anymore like a normal person does, and as we once used to prior to Accutane, whether prescription or over the counter. And my worse fear is that when and if we do need treatment, we either wont respond at all or respond adversely to some pharmaceuticals. In the aspect of pharmaceutical and chemical, rather than food, I feel as if my metabolism (don't know if this is a good example), that is the process that we break down compounds, is off. And, I am pretty sure I'm not the only one, as another member on here mentioned her experience with an ADHD medication before and after accutane was completely different. I think this is why we are forced to lean towards naturalist and holistic organic way of living, we really don't have a choice unless we want adverse effects.
If you took any of the newer anti histamines they dont cross the BBB. First generation ones like benadryl do, and increase serotonin, so maybe you did have mild serotonin toxicity. Benadryl is actually approved for treating OCD and depression.
You are onto something, i do not respond to things like i used to. I was into supps before accutane and i used to take like 500mg caffeine per day. Now i cant handle 100mg caffeine.. I also react way stronger than everyone i know to alcohol, supps, foods etc.
Natural is the way to go for sensitive individuals. Maybe it affected enzymes in the liver and we break stuff down slower so we reach higher blood plasma levels of substances that also stay there for longer
I remember pre accutane 10mg valium did nothing, after tane 5mg valium was like entering into another dimension, indicating huge brain changes post tane.
2 hours ago, trantran83333 said:
Thats great news!
Try all seafood, make sure they're ocean caught not farmed ones. I like barramundi and salmon. I should really go get some more oysters. Haven't had any for like 2 weeks. Getting withdrawal symptoms lol.
Have you tried probiotics also? Make sure to take them before bedtime. I heard it's better that way so to let them grow overnight.
Thats if u have gut problems like I do. The gut is also very important for healing
Its better to take probiotics first thing in the morning. They tend to be anti inflammatory and you want more inflammation at night. Also probiotics feed off the fiber you will eat in the day so its nice to populate the intestine in the morning pre eating.
At night isnt bad either ofc, i just think maybe morning is superior
2 hours ago, Lucas89 said:
Didn't many of you have these effects? I wonder how many side effects are just psychological.
They are not. Trust me ive mastered the ability to just let go and forget about accutane and that i am "sick" etc and i do enjoy being social, i have a gf etc. I am happy but symptoms do never go away, you just tend to accept it more so it feels normal.
But even if he feels normal he most likely did not regain his cognitive edge. I doubt he can perform that great even tho he feels good and enjoys life. But not everyone wants to be extremely good at things and perform well all the time. (most adults suffer brain fog without knowing it due to mediocre standard diet and alcohol/cigarettes etc)
But for me i want to be the best me i can, and just forgetting about this and thinking positive will not bring me there. I already have done that along with my research and good diet/supps for a long time. I doubt i would improve as much as i have with only positive mindset and letting go
3 hours ago, Lucas89 said:Didn't many of you have these effects? I wonder how many side effects are just psychological.
Yea, I had all those neurological deficiencies when I had Acne. But then I took Accutane and I was cured of all those when my acne dissapeared. Trust me, the acne is purely psychological man. Take Accutane, you wont regret it.
37 minutes ago, Lucas89 said:
I'm confused...
You're confused because you have acne. You need Accutane to remove your acne and cure you.
On 10/17/2015, 11:04:55, Lucas89 said:You shut the fuck up, bitch. What, is everyone supposed to feel sorry for you and not say anything except wallow in self pity because you have damage from Acccutane? You and that other guy (Macleod) are trying to censor anyone on this thread and keep trying to tell other members to "go away" because they dare post about anything other than what you think they should?
Hello, my name is Kevin and I still suffer from Accutane side effects. I'm a "veteran member" of acne.org, and I'd like to briefly share with you something about me, and hopefully you can take away something from it.
I took Accutane in 2010, it is now approaching the year 2016. I visited the doctor many times for an answer, excluded myself from social activity, and wasted money on supplements. Please take my word that none of those will do you any good. I'm sure many old-time members moved on because they realized, "Icannot allow Accutane to take anymore away from them, especially time".Don't get my wrong, to this day I am looking for a solution, but this does not mean to obsess over it and let the side effects paralyze your life. I am currently working harder than ever to graduate university, consistently hitting the gym, and pay close attention to my diet, hoping it would all come back to me in the future.
I've learned that the main problem was never acne, but the obsession over your physical appearance. This lead to myself, and probably many of you as well, making the regret of their life of taking Accutane. Please, I hope we can all learn from this lesson. If only we were patient enough to not act from impulses, from a quick fix, then we would not be spending so many years trying to fix a problem we caused. We need to own up to our mistake of taking Accutane. This leads to the end of my motivational talk, and my following solid advice for you guys.
Let me start withI am not cured.The main side effects I'm experiencing is thinning of hair (main problem), chronic dry skin, digestion problems, deteriorating vision, and anxiety.
My opinion is touse diet as your main solution to long-term Accutane side effects.
Kale and asparagus are staples. I started a plant based diet two weeks ago (not vegan or vegetarian). And I have cut off red meat and poultry from my diet.I am not advocating veganism.This post is dedicated to the recovery of our health, and I will not force upon my lifestyle on anyone. Ever since I started a plant based diet, which means for your diet to mainly consist of whole feeds, plants, and healthy eating in general, I have been rewarded with a few perks. By the way, I still eat fish every now and then.
1.) Naturally waking up earlier
2.) Brighter and healthier complexion
3.) Frequent bowel movements
I believe 1 and 3 are crucial in our recovery, because it is a sign that our body is properly functioning, almost like a machine.
Too many of use believe there is a quick fix to everything, which is why we took Accutane. Believe me, if something is too good to be true, it probably is. We are living in a generation where many of the lies told to us by society is finally starting to surface to our attention, thanks to the internet. What I mean is, negative news of authority,agriculture industry, pharmaceutical industry, and any other groups are swept under the rug, and we just turn a blind eye.All these speculation on the forums about supplements and research of chemical reactions are just what they are; studies. There is no way for any of it to be realistically proven to be effective to our problem unless we use ourselves as guinea pigs, which I strongly advise not to do. Lets stop believing that taking a pill can magically solve the problem. Besides, most of the supplements we are taking are found in foods. I don't think taking a mechanically measured dose 100mg Vitamin C pill is as effective as getting it from foods as we are intended to.I don't want to sound like a hippie, so I'll stop with this ramble before you guys think I'm "one of those people, but you get the point...
I hope we can put some attention not only on supplements and medications, but also a holistic approach to our problem. I did not create another thread because I feel like everyone with the same symptoms should gather on this one thread. I wish you all the best of luck, and remember to be patient, we got this.
"The doctor of the future will no longer treat the human frame with drugs, but rather will cure and prevent disease with nutrition" - Thomas Edison
TL:DR
Suffered side effects for 6 years. Focus on other life goals instead of obsessing over this problem. Look for a solution while continuing to live life. Use diet as a main approach. Plant based diet including asparagus and kale.Stop ingesting supplements and prescription drugs, you will most likely be left with another problem in the long run.
PS: Wow, I registered on this forum in November 2006. Its almost been a decade since I have been allowing acne and my concern of my physical appearance to dictate my life. Please, lets all stop this madness. I saw IndigoRush on youtube the other day and he seems like he's living life despite his Accutane side effects! Good on him
It is the purpose of this review to demonstrate that oral isotretinoin treatment restores all major pathogenetic factors of acne vulgaris by upregulation of the nuclear transcription factor FoxO1, which will be shown to be the major target of retinoid action. Nuclear FoxO1 deficiency is the result of increased growth factor signaling with activated phosphoinositol-3-kinase (PI3K) and Akt kinase during growth hormone signaling of puberty and increased insulin/IGF-1 signaling due to consumption of insulinotropic milk/dairy products as well as hyperglycemic carbohydrates of Western diet.
http://www.ncbi.nlm.nih.gov/pubmed/20930691
In addition, insulin downregulates FOXO1 activity by augmenting ubiquitination of FOXO1 and enhancing FOXO1 degradation (Matsuzaki et al. 2003).
Taurine Mimics Effects of Insulin
Even administered on its own (without insulin) theanorexic effect of taurine had a "similar magnitude to the effect produced by either insulin or leptin"
http://suppversity.blogspot.com/2011/08/taurine-mimics-effects-of-insulin.html
injection of an acute dose of taurinereduces food intakeand locomotor activity, andactivates signal transduction through the Akt/FOXO1, JAK2/STAT3 and mTOR/AMPK/ACCsignaling pathways. These effects are accompanied by the modulation of expression of NPY. In addition,taurine can enhance the anorexigenic action of insulin.
http://www.ncbi.nlm.nih.gov/pubmed/22130357
ACCUTANE upregulates FOXO1 = Insulin downregulates FOXO1 thru PI3K and AKT = TAURINE acts like insulin downregulatingFOXO1 thru AKT AMPK
Listen, to all of the people posting about eating right and thinking this away... thats great. Its not the answer, but do what you guys have to. Accutane(excess retinoid) is only removed from the body in one of two ways ... by glucuronidation and taurine conjugation. We need to focus on that. To the people that are crashing, i dont know... it could be second or third derivativeof the problem, i.e. accutane got rid of the methionine, which caused copper to accumulate in the liver, by taking taurine , you could be causing a copper dump and crashing... but you need to keep going!!! when youre going thru hell, dont stop.
http://gutenberg.us/articles/hypervitaminosis_a
TREATMENT
Toxicity has been shown to be mitigated throughvitamin E(tocopherol),cholesterol,zinc,taurine, andcalcium.[8]
Cholesterol has been shown to prevent retinol inducedgolgifragmentation.[9]
Retinoids can be conjugated by taurine and other substances. Significant amounts of retinotaurine are excreted in the bile,[10]and it is believed this retinol conjugate is an excretory form as it has little biological activity.[11]In rats, the toxic effects of vitamin A were significantly reduced when diets were supplemented with taurine,[12]and also Cholestin.[13]
3 hours ago, sanadai said:Hello, my name is Kevin and I still suffer from Accutane side effects.
Let me start withI am not cured.The main side effects I'm experiencing is thinning of hair (main problem), chronic dry skin, digestion problems, deteriorating vision, and anxiety.
Every one of your side effects could be a sign of taurine deficiency. I stuck my head in the ground for 10+ years and tried to "live" as well. its not the answer... trust me.
anxiety
As a GABAergic compound, Taurine can inhibit the neurological processes that result in anxiety or stress. It has also been observed to lower cortisol levels. This might also explain why Taurine is so oftenconsumed with caffeine, so as to offset some of the negative side effects like nervousness and restlessness.
hair thinning
http://www.hairloss-research.org/UpdateTaurineandWorms3-13.html
digestion and vision
It is a key ingredient of bile, which in turn is needed forfat digestion, absorption of fat-soluble vitamins as well as the control of cholesterol serum levels in the body. (It is incorporated in the bile acid chenodeoxychloic acid, which emulsify thedietary fats). This nutrient is also used in the proper use of potassium, calcium, as well as sodium in the body, and for maintainingcell membraneintegrity. It is thought to be helpful with anxiety, hyperactivity, poorbrain functionand epilepsy as well as hydrating the brain. Taurine, together with zinc, is also required for proper eye health and vision.
dry skin
http://journal.scconline.org/pdf/cc2006/cc057n01/p00001-p00010.pdf
s. In conclusion, our data suggest a role for taurine in preventing surfactant-induced dry and scaly skin by modulating the proinflammatory response and stimulating epidermal lipid synthesis
2 hours ago, tryingtohelp2014 said:
Every one of your side effects could be a sign of taurine deficiency. I stuck my head in the ground for 10+ years and tried to "live" as well. its not the answer... trust me.
anxiety
As a GABAergic compound, Taurine can inhibit the neurological processes that result in anxiety or stress. It has also been observed to lower cortisol levels. This might also explain why Taurine is so oftenconsumed with caffeine, so as to offset some of the negative side effects like nervousness and restlessness.
hair thinning
http://www.hairloss-research.org/UpdateTaurineandWorms3-13.html
digestion and vision
It is a key ingredient of bile, which in turn is needed forfat digestion, absorption of fat-soluble vitamins as well as the control of cholesterol serum levels in the body. (It is incorporated in the bile acid chenodeoxychloic acid, which emulsify thedietary fats). This nutrient is also used in the proper use of potassium, calcium, as well as sodium in the body, and for maintainingcell membraneintegrity. It is thought to be helpful with anxiety, hyperactivity, poorbrain functionand epilepsy as well as hydrating the brain. Taurine, together with zinc, is also required for proper eye health and vision.
dry skin
http://journal.scconline.org/pdf/cc2006/cc057n01/p00001-p00010.pdf
s. In conclusion, our data suggest a role for taurine in preventing surfactant-induced dry and scaly skin by modulating the proinflammatory response and stimulating epidermal lipid synthesis
I like what I'm reading here about Taurine being the supplement of choice. I've been using it now for 2 weeks with no noticeable results thus far.
I'll keep using it and see what happens. The part about hydrating brain sounds very appealing as my entire body feels dried out.....only 18 years after taking the poison.
Thanks for posting!!
On 2/12/2015, 8:23:22, Modeaa said:https://en.wikipedia.org/wiki/5-alpha_reductase 5-reductases, also known as 3-oxo-5-steroid ''4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis''
pancreatin- if it breaks fibrin it can help against biofilm. i read also somewhere that fibrin breaking is good for varicose veins.
for vessels/veins/capillaries insefficency/leakage/stasis,poor circulation,lymph subject i am reading also about :
flavanoids from foods/diomsin/horse-chestunt/Butcher's Broom /Gotu Kola/NAG/more..
i am looking what things can make the vessels strong for preventing them to leak while the attempting to increase circulation with other herbs. fixing the gut in theory might do this( http://ajpgi.physiology.org/content/254/3/G389 -Lymphatic pathways and role of valves in lymph propulsion from small intestine )
i think that for fixing the gut the vesells and the circulation should be attempet to get better as well at the same time. What makes me think that this vessels thing might be going on from the drug is that scince accutane i have permiment veins under my eyes. and this information:
http://www.ncbi.nlm.nih.gov/pubmed/16703787
Possible reasons for the patient's facial swelling include some type of retinoid induced angioedema, exacerbation of inflammation by isotretinoin, and isotretinoin induced capillary leak syndrome.
https://books.google.co.il/books?id=b4_9QwU9Z0kC&pg=PA605&lpg=PA605&dq=13-cis+retinoic+acid+lymph&source=bl&ots=s0qBl8Udnw&sig=-xJrlkmcvRmTMj9SONb0R9vVQfw&hl=iw&sa=X&ei=wI5gVfzZOIO7swHciIHACw&ved=0CGoQ6AEwCQ#v=onepage&q=the lymphatic system&f=false''When the retinol dose was raised, an overproportional increase in retinoic acid metabolites where found in both the mouse and monkey. These finding indicate that the usual patways of retinol resorption---hydrolysis od esters, binding to creb 2, reesterification, transport via the lymphatic system----- might become saturated and a porotion of the dose, esacaping these endogenous mechanisms''
the Intracranial pressure i think is also because of this vessels issue.
http://www.nature.co...lication_detail
''we reported 98% inhibition of neutrophil and moocyte chemotaxix following isotretinoin treatment''
'' we suspect that isotretinoin effects on endothelial/neutrophil intercations may be an importent site of action''
''we have reported preliminary information on inhibition of neutrophil migration through endotelial cell-coated filters by isotretinoin(4)''
https://en.wikipedia.org/wiki/ Endothelium
''The endothelium is the thin layer of simple squamous cells that lines the interior surface of blood vessels and lymphatic vessels,[1] forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. The cells that form the endothelium are called endothelial cells. Endothelial cells in direct contact with blood are called vascular endothelial cells, whereas those in direct contact with lymph are known as lymphatic endothelial cells.''https://en.wikipedia.org/wiki/ Hypophyseal_portal_system
''Occlusions and other issues in the blood vessels of the hypophysial portal system can also cause complications in the exchange of hormones between the hypothalamus and the pituitary gland.''
this could mean less
https://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone
''Gonadotropin-releasing hormone (GnRH)....is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.''
and less FSH and LH menas less andeogens/testosteron and more.
https://en.wikipedia.org/wiki/ Diosmin
Diosmin is semisynthetic drug (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD)
.....''Mechanisms
Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.''
''Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries. Furthermore, diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.''
flavanoids (lolaccutane green tea has it):
Cardiovascular diseases
Among the most intensively studied of general human disorders possibly affected by dietary flavonoids, preliminary cardiovascular disease research has revealed the following mechanisms under investigation in patients or normal subjects:[46][47][48][49][50]
- inhibit coagulation, thrombus formation or platelet aggregation
- reduce risk of atherosclerosis
- reduce arterial blood pressure and risk of hypertension
- reduce oxidative stress and related signaling pathways in blood vessel cells
- modify vascular inflammatory mechanisms
- improve endothelial and capillary function
- modify blood lipid levels
- regulate carbohydrate and glucose metabolism
- modify mechanisms of aging
there are manny supps for veins on iherb two formulas for exapm: (i am not going to by any of them at the moment. but in case someone is intrested or can report on an ingredient in it or other he used
http://www.iherb.com/Life-Time-Diosmin-Complex-60-Capsules/11037
http://www.iherb.com/FutureBiotics-VeinFactors-Varicose-Vein-Complex-90-Veggie-Caps/7293
Excellent post. There is definitely something going on post accutane with cardio system, Ive said before my legs are swollen and I've got veins in weird places that are really noticeable, I'll look into some of these supplements next. Can't just keep buying more when I don't know the source of the problem - we all seem to be chucking mud at a wall in the hope that something sticks, that's totally understandable given our situation, but I can't nor do I want to take 15 to 20 supplements for the rest of my life, that's just not right. Having said that, to the person who got diagnosed with a hypothalamus/hormone problem - what is the outcome, what did the doctor suggest or proscribe for you???
The endocrinologist who I saw 10 years ago and who couldn't find anything wrong with me said to take selenium??
On 2/12/2015, 8:23:22, Modeaa said:
16 hours ago, sanadai said:
Suffered side effects for 6 years. Focus on other life goals instead of obsessing over this problem. Look for a solution while continuing to live life. Use diet as a main approach. Plant based diet including asparagus and kale.Stop ingesting supplements and prescription drugs, you will most likely be left with another problem in the long run.
You are full of shit if you think supps and drugs cant help.
Ive already had a flawless plant based diet for 2 years and i only recently started obsessing over this problem because i got a lot better the more i did. The more i obsess the more i learn, the more i try and the more i improve.
Hence my name relentless, i wont stop trying and researching until i find out how to fix this shit.
I still enjoy my life and live normally in the meantime (with the exception of being unable to work, but i still have friends, family, girlfriend, studying, hobbies in addition to my diet, workouts and supps. I also have a healthy relationship with several doctors and some drugs are useful, but they are band aids. They can be cures for certain things. Hormone replacement can be a cure if you lack hormones and naturally cant increase them. Antibiotics can be a cure if you cant get rid of an infection with natural substances.
Again food and positive thinking only goes so far..
Even if you are healthy to begin with you could still be far better than normal if you went into doing more than just eating veggies and good foods..
+ most supps are compareable to food so its not like there will be problems. Many supps are extracts from foods/herbs. Which is more often than not far safer and more superior than actually consuming the real food/herb itself. Due to consistent high quality, practicality, purity and even dose etc.
If you are scared of long term effects then only use stuff that has long term evaluation in studies.
Taurine is confirmed to be safe for life up to 3g daily
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Can someone do a TLDR on what Fox0 does and why its bad that accutane altered it?
10 hours ago, TrueJustice said:but I can't nor do I want to take 15 to 20 supplements for the rest of my life, that's just not right.
Some people who have never been sick take upwards of 50 supps per day for the sole reason of becoming a better version of themselves.
To each their own
I like taking supps (i take less than 10 daily though)
But i plan on eventually just figuring out everything that works for me and why it works and then take it. I dont care if its 50 a day if its much much better than taking zero.
It depends of course, sometimes i want to save moeny and i just take nutrients that i dont get from diet.
But i want to be a doctor so i naturally have huge interest in researching and trying all kinds of stuff, purely to have first hand experience. I want to help people in the future and knowing first hand what good or bad can happen from taking something is really valuable.
Before someone flames me for wanting to take as many supps as possible.
i also want to eat as many foods that make me feel good as possible.
So if that means having 100 different fruits/veggies/herbs/berries and 50 supps per day and + all other beneficial stuff i can incorporate into my life, then i will gladly do it.
12 hours ago, TrueJustice said:
I like what I'm reading here about Taurine being the supplement of choice. I've been using it now for 2 weeks with no noticeable results thus far.
I'll keep using it and see what happens. The part about hydrating brain sounds very appealing as my entire body feels dried out.....only 18 years after taking the poison.
Thanks for posting!!
I've been taking taurine (2-3g per day) for a couple of weeks and I definitely feel more relaxed since starting, and I'm pretty certain it's not a placebo effect. In high stress situations, like under pressure at work, I used to feel the stress on my chest and feel like was really tensed up, but now even in stressful situations I don't get this at all and still feelrelaxed. This alone makes it worthwhile as a supplement, and other benefits may come over time or with increaseddosages.
I think it might also allow me to get back onto other sups which I've found have helped, but also had negative effects, like choline which I definitely foundimproved sensation for me, but also made me feelmore stressed - potentially through raising cortisol (mine is already high according to post-tane blood tests). One thing I've just got hold of is NADH which I plan to introduce some time (NAD seems difficult to find - 'NOW' have discontinued it too, so settled for NADH (the reduced form of NAD).
1 hour ago, Relentless1k said:But i plan on eventually just figuring out everything that works for me and why it works and then take it. I dont care if its 50 a day if its much much better than taking zero.
I'm thinking along these lines too, doing whatever you can to lessen side-effects while looking/waiting for a permanent solution, which will almost certainly be found once the accutanes mechanisms are fully understood. The effect of some supplements can be as powerful as pharmaceuticals drugs, and many are prescribed as such, look at NAC for example.
Like the sound of the potential of NADH (although I have personally yet to try supplementing)
NADH is the primary coenzyme that drives reduction and
oxidation reactions in cellular metabolism. Not only
is it a powerful antioxidant within the cell during
intense metabolic reactions, each NADH molecule
produces the following (Passwater 1998):
(1) 3 molecules of ATP
(2) 6 molecules of Dopamine
(3) 1 molecule from oxidized glutathione to its active
reduced form
(4) Reduced glutathione regenerates spent vitamin C,
for regeneration of spent vitamin E
NADH occurs in all human cells playing a major
metabolic role in the energy process, DNA repair,
memory, and Adenosine Triphosphate regeneration during
endurance exercise. While NADH is found in red meat,
poultry, and yeast, most of it gets destroyed when
processed, cooked, and degraded by stomach acids.
The more coenzyme NADH is available within cell
metabolic reactions, the more energy the cell may
generate. The deficiency of this coenzyme will
proportionately slow down enzymatic processes
resulting in fatigue, chronic fatigue syndrome,
Alzheimer's, Parkinson's, and several other
degenerative diseases (Birkmayer 1996) common to our
aging population..
Ordered some taurine, looks promising from what I've read in this thread.
Finished my course of accutane in Feb of this year. Symptoms are (currently): moderate upper abdominal bloating, difficulty getting a deep breath (likely due to bloating), chronic dry skin (present before but exacerbated by accutane), keratosis pilaris (probably linked to the dry skin in some way), fatty stools (likely bile related),brain fog, poor sleep, fatigue, pain in left wrist andhot flushes with subsequent skin itchiness and redness.
I've been taking 6g of MSM daily for about a month now and 10,000 IU Vitamin D3 daily for about 2 weeks. These seem to be helping my skin related issues slightly, but no luck so far on the bloating and breathing issues etcso I'm hoping taurine will help with those.
Ihad some blood tests done a few months ago to rule out a bunch of things like diabetes, thyroid issues, kidneys, blood count etc but everything came back looking totally fine.
All of these problems that people are dealing with seem like very normal issues that happen to millions of people who have never taken Accutane. Thinning hair? My roommate in college was bald at 21, he never touched Accutane. My mother is partially bald, shes never touched the stuff. Anxiety? welcome to half of the world population, anxiety and depression medications are among the most common prescribed in America, you think all those people took Accutane?? NO!! 7% of the American population suffers from chronic depression. They must have all taken Accutane. Digestive issues? we eat a shitload of processed food with hormones our whole life, 1/3rd of the population in America is obese, thats 100,000,000 people. Everyone has stomach issues. Dry skin?? walk down the beauty section of a Walmart, there are 100s of lotions and moisturizers to choose from, you think they were all made because people took Accutane?? My father has the driest skin ive ever seen, his lips constantly crack and so do his knuckles, you guessed it, hes never taken Accutane.
I get so tired of hearing people complain about the side effects of Accutane. When you were in the midst of your acne, tell me you didnt stay up at night saying you would give anything for it to go away.
I spoke with my derm about the side effects of Accutane and he has been prescribing it for 25 years. He said he has had zero patients have any of the horrible side effects, he has had to take a number of people off because of bad blood work, but nothing else ever happened.
Look, life is shitty, people get old, you will have problems, but most of the time, they are just that, normal problems. Its not because of Accutane. You probably would have had these problems no matter what.
Sorry for the rant, im just sick of reading all of these normal issues people deal with everyday blamed on Accutane.
34 minutes ago, Jones4545 said:All of these problems that people are dealing with seem like very normal issues that happen to millions of people who have never taken Accutane. Thinning hair? My roommate in college was bald at 21, he never touched Accutane. My mother is partially bald, shes never touched the stuff. Anxiety? welcome to half of the world population, anxiety and depression medications are among the most common prescribed in America, you think all those people took Accutane?? NO!! 7% of the American population suffers from chronic depression. They must have all taken Accutane. Digestive issues? we eat a shitload of processed food with hormones our whole life, 1/3rd of the population in America is obese, thats 100,000,000 people. Everyone has stomach issues. Dry skin?? walk down the beauty section of a Walmart, there are 100s of lotions and moisturizers to choose from, you think they were all made because people took Accutane?? My father has the driest skin ive ever seen, his lips constantly crack and so do his knuckles, you guessed it, hes never taken Accutane.
I get so tired of hearing people complain about the side effects of Accutane. When you were in the midst of your acne, tell me you didnt stay up at night saying you would give anything for it to go away.
You know, I get where you're coming from and I kind ofagree with you when it comes to some of theseconditions, like hair loss, anxiety anddepression and for certain people. But for others it's a totally different story.I mean I've had anxiety for years and Iknow it's hadnothing to do with taking accutane in my case.But with some issues; I believe there is a link to the usage of accutane. I had extremely bad acid reflux and stomach pain after I finished my course, which you could just say is a coincidence; but when so many people report things like this after taking accutane it almost seems too coincidental andI think it's hard to totally refute the idea that accutanemighthave caused these issues in some people.
34 minutes ago, Jones4545 said:I spoke with my derm about the side effects of Accutane and he has been prescribing it for 25 years. He said he has had zero patients have any of the horrible side effects, he has had to take a number of people off because of bad blood work, but nothing else ever happened.
The thing is, from what I've read of peoples experiences at least, often they don't start havingissues until weeks, if not months after they've finished their course, like myself. And unless your derm, or derms in general follow up with their patients months after finishing (mine certainly didn't),how could they possibly know if they've developed side effects or not?