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8 hours ago, Kokodu said:
But trying SRD5a1 he won't be drunk.
Sounds interesting. We should find people who tried it and shared their effects after SRD5a1.
Don't mind allantookaccutane he is just trolling us.
Hey MODEAA,
Our dht status is only fine on the test. But Serum dht says nothing about the Gene/Enzyme activity (SRD5a1). Sry for my language but many peoples say that Not only their Balls but also the Penis is shrunken (the cause for this is SRD5a1 downregulation, so we need to kickstart it. Androgen receptors are activated by Testosterone but much more from DHT! We should search for natural solutions First, witch Sounds more easy as it is..
6 hours ago, SaffronAide said:Don't mind allantookaccutane he is just trolling us.
You spelled my name wrong you son of a bitch
Idk I feel better and better eating more and more seafood and drinking almost a gallon of acqua panna a day. I also watch the sunrise everyday and try to ground/earth with my bare feet but it's getting colder and I'mtryna find a way around it. Lots of lamb and pork, lots of salmon, sardines,oysters, and butterand I'm feeling better. I'm focused, happy, attentive, skin is getting less dry (still dry and antibacterial soap still kills the skin on my knuckles), lips are less chapped than in the summer even though it's winter (no lip balm except rubbing occasional ghee when I got some extra on my spoon)and my ibs is getting way better. Anxiety down. I'm supplementing mag malate, mag threonate, green tea extract (noticeable mood difference 10-15 mins after taking this, every single time), lots of betaine HCL and ox bile and pancreatin. I was supplementing crazy amounts of anything you can think ofbut I've ramped down. Alan isn't 100% insane, more like 98% lol. Food is deff the way to go, with some choice supps. Also, apparently shiitake and oyster mushrooms have very bioavailable active b vitamins. They've been a part of my protocol too. I also swear my dick got bigger but idk what to attribute that too... Keep up the good fight
Also, If I skip ox bile for a day or two I feel very crummy. Deff another liver/gallbladder link...
Just been reading an interesting thread on phoenix rising regarding accutanes GNMT upregulation, and theories on how to overcome this.
The thread references this thread - I don't suppose anyone has been in contact with the user on there with the username 'name'?
9 hours ago, Lucas89 said:Why do some people on here say that Accutane causes anxiety/depression? What causes this in the brain? Is it damage by Accutane? Why do some people get these disorders without ever taking medication, while others say they get it after they took medication?
Because its been proven to in studies. The same reason some people get headaches without ever hitting their head. Sometimes there can be multiple causes to the same 'disease'.
Fellow accutane sufferer checking in. Took it in 2012 and everything went downhill after that. Severe GI issues, libido, heart, liver, kidneys, depression, anxiety etc.
I've been really active in researching the damage it might have done and also just understanding how the body works and how to at least optimize it, even if it cant be fully fixed. This includes lifestyle, diet, supplements, meds/drugs and technology.
I wont lay out my story or all symptoms in this post but im 100% unable to work or study so im full time commited to solving this riddle.
Will contribute as much as i can with studies and own experiences etc, and discuss other peoples findings 
(Ive followed the thread on and off since early 2013 so ive read most the pages)
Guys I have found another interesting thing on the internet. It talks about Allopregnanolone, a metabolite from progesterone and 5 alpha dihydrotestosterone. There was a young guy on this forum who recoverd really good in a little time as 1 week using an SSRI (Cipralex in an very low dose) His erectile dysfunction was gone away. Now I have read, that some SSRI's like Prozac increase neurosteroids significantly even in extremely low dose, without chainging serotonin or ather brain chemicals (look that SSRI's can have bad side effects, including erectile dysfunction used in high/normal doses for depression!) But I think that for us it would be ok to use it in a low dose maybe to 0,5-1 mg wich is very low. Awnser what you think about. (If you google cipralex accutane damage, or cipralex ssri accutane damage you can read the guys article). If you wanna try be very cautious!! because it can have bad sides too. I only wantet to share this..
Greetings
5 hours ago, manalesenicola said:Guys I have found another interesting thing on the internet. It talks about Allopregnanolone, a metabolite from progesterone and 5 alpha dihydrotestosterone. There was a young guy on this forum who recoverd really good in a little time as 1 week using an SSRI (Cipralex in an very low dose) His erectile dysfunction was gone away. Now I have read, that some SSRI's like Prozac increase neurosteroids significantly even in extremely low dose, without chainging serotonin or ather brain chemicals (look that SSRI's can have bad side effects, including erectile dysfunction used in high/normal doses for depression!) But I think that for us it would be ok to use it in a low dose maybe to 0,5-1 mg wich is very low. Awnser what you think about. (If you google cipralex accutane damage, or cipralex ssri accutane damage you can read the guys article). If you wanna try be very cautious!! because it can have bad sides too. I only wantet to share this..
Greetings
Is there any other safe DHT boosters ?
i have low semen volume problem and im scared to grow less. Ithink my T and DHT decreased , because i have low semen volume and this problem directly associate with hormones !
is there any other advice for me ?
i dont want to use another drug , like antidepressants !
On 2 December 2015 at 3:59:55 AM, lolaccutane said:Idk I feel better and better eating more and more seafood and drinking almost a gallon of acqua panna a day. I also watch the sunrise everyday and try to ground/earth with my bare feet but it's getting colder and I'mtryna find a way around it. Lots of lamb and pork, lots of salmon, sardines,oysters, and butterand I'm feeling better. I'm focused, happy, attentive, skin is getting less dry (still dry and antibacterial soap still kills the skin on my knuckles), lips are less chapped than in the summer even though it's winter (no lip balm except rubbing occasional ghee when I got some extra on my spoon)and my ibs is getting way better. Anxiety down. I'm supplementing mag malate, mag threonate, green tea extract (noticeable mood difference 10-15 mins after taking this, every single time), lots of betaine HCL and ox bile and pancreatin. I was supplementing crazy amounts of anything you can think ofbut I've ramped down. Alan isn't 100% insane, more like 98% lol. Food is deff the way to go, with some choice supps. Also, apparently shiitake and oyster mushrooms have very bioavailable active b vitamins. They've been a part of my protocol too. I also swear my dick got bigger but idk what to attribute that too... Keep up the good fight
Also, If I skip ox bile for a day or two I feel very crummy. Deff another liver/gallbladder link...
You're spot on, food is the way to go. You're on the right track with seafood.
Try adding broccoli, cauli, red cabbage red onion and endive to your diet.
juice orange, Roma tomato celery Granny Smith apples and Beetroot or what ever u want, just keep sugar to a minimum.
i was really good on taurine for a few weeks then I crashed again. I knocked something out of balance again.
See with food, it can't do that coz your body only absorbs what it needs.
I've been using taurine since last week for a few days,and have noticed it induced a mild, relaxed feeling and helps me get to sleep (and thats coming from someone with extreme sleep disturbance), but havn't noticed anything else. Good to keep some on hand as its dirt cheap.
2-5g seems to be a good experimental range. Cant taste it and mixes easily.
On 12/4/2015 3:11:42, AlanTookAccutaneWow said:Well, i feel like shit and hate my life.
We all feel the same Alan , but why you are not helping us with your knowledge ?
why you are so agressive and why you are posting pointless empty posts here ? just discuss things , thats how we can find a cure !
lets make peace and help each other.
I dont mind that you called me son of a bi*** for NO REASON !
Also are you the ; "Alanc" or Took_Accutane on Allthingsmale forum ? i see you in that forum much.
Reasons for taurine helping sleep:
http://www.jneurosci.org/content/28/1/106.full
Does anyone have red dots on their tongue like this:
http://www.evernote.com/l/AbFXjj9q295JhJrea77B3zaOIUUfcKLqbNU/
3 hours ago, manalesenicola said:Someone has tried DHA supplement? It lowers foxo1. But omega 3's/Fish oil are not good to us. Maybe someone has tried dha only?
Why do you say omega 3's are bad for tane' sufferers?I dont know why,but if its because of retinol (vit A), i too feared that for years, but concluded its still good. I HIGHLY doubt accutane screws over the systems involved in processing A. Accutane is already a "pre converted" form of retinol and its not entirely similar, and does not share nutrient status with actual vit A as far as i know. (I might be wrong of course)
There might be another reason why you fear fish oil (i can only think of blood thinning, but thats healthy)
DHA/EPA would work fine isolated, from either fish or algae sources. I have a good experience with both. Advice would be to stick with minimum effective dose, as overdoing it just gives negative results (to healthy ppl as well)
---------------
Taurine
I see you guys recently started trying out and discussing taurine, heres my recent effects from it:
5g of taurine with 3g ish of glycine produced a really potent effect in me. 1g taurine and up to 10g of glycine in isolation does not do this so im thinking its either just the 5g of taurine or maaaaybe the combination.
Results were:
The heart palpitations that ive had for a year are gone, (Heart beating really hard/increased awareness of it beating in upper body, neck and head 24/7)
Slowing of heart rate (mine was elevated)
-Breathing problems gone
Extreme reduction in anxiety similar to benzo's (pharma anti anxiety meds)and or phenibut. (Also a pharmaceutrical anti anxiety med but its legal as a supplement, really powerful stuff. Dont mess with it..)
My depression is gone and i cant force myself to think negative at all (this obviously wont last i assume, but its nice to know it works and can be used on particularly bad days.)
General well being and reduction in fatigue (I have diagnosed CFS/ME)
- Eliminated caffeine side effects (severe anxiety, panic, and heart palpitations/arrhythmia)
- Being social/speaking in general is really easy and i have a very willing urge to get stuff done and generally a big willingness to live and do fun stuff. (Which i usually dont)
Probably wont happen every time,but this effect is potent and beats nearly everything else ive used. And theres literally very few supplements i havent used. I only have some herbs left to try then ive tried everything unless i pre determined it wont help me.
Only thing more powerful is benzos and pheni. But low dose pheni is weaker.
Ive taken 1-2g taurine for a long time so i was not deficient.
On 12/3/2015, 10:29:51, SaffronAide said:Is there any other safe DHT boosters ?
i have low semen volume problem and im scared to grow less. Ithink my T and DHT decreased , because i have low semen volume and this problem directly associate with hormones !
is there any other advice for me ?
i dont want to use another drug , like antidepressants !
Pregnenolone, DHEA (pregnenolone converts to this so u dont need both)and creatine boosts it. Boosting T obviously boosts DHT if the conversion enzyme works. There might be ways to increase that naturally. I cant speak for tane, but propecia/finasteride does not inhibit the conversion from T to DHT permanently, so maybe tane doesnt either. But as pointed out in this thread earlier there is potential for it destroying the enzyme in the skin which does result in low DHT for life via that conversion route.
You can test T, DHT and DHEA levels with a doctor or through a private lab. Tends to show up as normal, which might indicate serum values wont really reflect your symptoms, or it means your symptoms are not actually caused by low level of hormones.
My T raised a lot since accutane reduced it and i supplemented DHEA for a few months and i have the ability to have sex 4-5 times daily now, where as after accutane i could not do it once in a year. Couldnt even get it up with viagra/cialis. Now i never touch anything to help with libido/ED.
32 minutes ago, Relentless1k said:Pregnenolone, DHEA (pregnenolone converts to this so u dont need both)and creatine boosts it. Boosting T obviously boosts DHT if the conversion enzyme works. There might be ways to increase that naturally. I cant speak for tane, but propecia/finasteride does not inhibit the conversion from T to DHT permanently, so maybe tane doesnt either. But as pointed out in this thread earlier there is potential for it destroying the enzyme in the skin which does result in low DHT for life via that conversion route.
You can test T, DHT and DHEA levels with a doctor or through a private lab. Tends to show up as normal, which might indicate serum values wont really reflect your symptoms, or it means your symptoms are not actually caused by low level of hormones.
My T raised a lot since accutane reduced it and i supplemented DHEA for a few months and i have the ability to have sex 4-5 times daily now, where as after accutane i could not do it once in a year. Couldnt even get it up with viagra/cialis. Now i never touch anything to help with libido/ED.
Relentless, can you explain other than Taurine what you did? What other things you take? Diet? Exercise? etc.??/
18 hours ago, marlin15 said:Relentless, can you explain other than Taurine what you did? What other things you take? Diet? Exercise? etc.??/
Sure thing! Its really late so excuse me if my answer is a mess full of typos etc.
My general advice:
Diet: Try out foods one by one to figure out if it works for you. If you already have foods you are 100% that works for you, just stick to those. Its not dangerous to miss out on nutrients for 1-2 days. Guaranteed safe foods: Chicken breast, honey and ghee (clarified butter)
Diet might actually play much more of a role than you think. And its more important to stay away from bad stuff, than to have a lot of veggies etc. Thats an enhancement. Im sensitive to almost anything and everything, and the reason for this is lectins in the food. I do really well with all low lectin foods. Except for high histamine foods, but im working on stabilizing mast cells and generally reducing histamine. Antihistamine meds work in the meantime.
High lectin foods: Grains, legumes (soy/beans/lentils), nuts, potatoes, rice (even white) and dairy.
Foods to try:
- All meats, eggs and seafood but not sausages and bacon/processed meats (i do best with wild cod and organic chicken. I can only get grain fed beef and farmed salmon so i dont bother with those)
If you are a vegan or want protein powders get pea protein and sprouted brown rice protein. Also hemp protein is good. Whey can be good if you tolerate it. Jarrow and NOW are good brands. Use carob, honey, stevia and berries with the protein for a nice shake. Also vanilla powder and cocoa if you handle it. Other fruit and flavorings works as well. Sweeteners of choice are: stevia, xylitol and if needed sucralose. Stay away from sucralose unless you really need it.
- Cruciferous veggies and leafy greens (broccoli, cauliflower, cabbage, spinach, kale etc)
- Mushrooms
- All berries, pineapple, papaya, watermelon, mango. Focus on berries.
- Most other fruits and veggies are fine, try them out. The ones i listed are the safest.
- Honey for carbs Max 100g per day, or less if you have fruit. Its rather important not to exceed 50g fructose per day, but not a crisis if you do. Try to reserve going overboard on sugary foods for social situations
- Fats from seafood, ghee or grass fed butter (if you tolerate it) cod liver oil, extra virgin olive oil, black seed oil, avocados. And MCT oil or caprylic acid if you dont struggle with food allergies. MCT/Caprylic not needed, just an enhancement.
Try not to go overboard with total omega 6 content for the day. You can also try out coconut oil and palm oil (extra virgin and organic for both obviously) Have as much butter/ghee as you tolerate. I dont do very well with saturated fat (it makes me tired), but its actually healthy. Up to 50g a day is really safe if you are worried about it.
- Purple sweet potatoes for more carbs if you need (Or regular ones if you cant get purple ones. Orange sweet potatoes are not that good, but better than most other starch sources. Better than regular potatoes)
KEEP IN MIND YOU COULD BE ALLERGIC OR HAVE SOME NEGATIVE SYMPTOMS FROM EATING ANY OF THESE FOODS, TRY THEM OUT FOR YOURSELF. I dont handle blueberries, blackberries or spinach. (Likely due to histamine) And eggs i have an allergy to.
Go for organic, wild caught, free range, grass fed etc if you can. Not extremely crucial.
Avoid caffeine and alcohol if you can. (Reserve caffeine for extreme fatigue and alcohol for social situations where you want to drink, if you can tolerate it)
Good macros to try to hit for the day as a baseline:
Protein: 70-150
Carbs: 125-200
Fat: 70-120
Just increase them if you want to eat more calories. You dont really need more than 1500-1900calories per day (for a 6'1 170lbs male) More is useful if you want to gain muscle, but if your digestion is messed up dont go overboard. Restricting calories and bad food choices is more powerful at reducing inflammation and oxidative stress than all supplements. Diet is more important than supplements.
Exercise: Weight lifting 2-4x per week. Im not going to explain how to do this, but the workout doesnt have to be long. (20-60min is more than enough to train several muscle groups) Cardio if you want to.. 2-3x per week of sprinting/high intensity intervals.
Walk as much as you can, stand as much as you can. Avoid sitting and lying down too much. (this and weight lifting is most important)
Do yoga id you'd like. Its not crucial but does reduce stress, increase flexibility etc.
Supplement whatever vitamins and minerals you lack from diet. Its hard to give advice on this without knowing what you eat.
General advice:
D3 and K2
B Complex (Jarrow B-right is good, because it has active forms and methylfolate) and sublingual B12. (Jarrow methylcobalamin)
Vitamin C (1-4g daily)
Coral calcium if no dairy.
Iodine (up to 400mcg daily)
Magnesium (i use ionic citrate dissolved in water. Glycinate is also good. Some other forms are also good) You can try up to 800mg daily but be vary of diarrhea..
Potassium gluconate (extremely hard to get enough potassium in diet. RDA is 4700mg daily. Be careful with this supplement. You cant take a lot at once, because you absorb it so fast that it will cause temporary too much potassium in the blood. I usually get 1,2g-2g per day from supplement. Get capsules for more accurate dose if you dont have mg scale. Usually 99mg per capsule)
I use this one for the rest of the minerals: iherb.com/Nutricology-MultiMin-120-Veggie-Caps/15510
Use whatever other form of vitamin/mineral or brand you want. Just try to determine what you actually need. Its not good to get too much of nutrients, even the water soluble ones have side effects (but are not toxic)
Good supplements: (The ones marked with "careful", please research or ask for advice on those, cuz they are not to mess around with) I dont take some of these and i also have used and or take many others, but these are generally really good. Just read up on what they do before you take them.
Longvida curcumin (up to 2g daily) (Other curcumins do not reach the brain. Meriva is good for body inflammation only. Many brands carry these. NOW carries longvida and its called curcubrain)
NAC (600mg-1,2g)
Taurine (1-6g)
Creatine (2-5g)
Beta alanine (max 5g)
Inositol (1-20g)
SAM-e (make sure you already get enough methylfolate and methylb12) (careful) (200-800mg)
TMG (500mg - 1,5g)
Melatonin (0.3-1,5mg)
DHEA (careful) (25mg)
Pregnenolone (careful) (25-50mg)
Liposomal glutathione (1 packet/serving)
Liposomal vitamin c (1-2g)
PQQ (20-40mg)
CoQ10 (ubiquinol or mitoQ) (100-600mg) Or 5-15mg MitoQ
NIAGEN/NAD+ (150-600mg)
L carnitine (1-2g)
N-acetyl L-tyrosine (350mg-700mg)
Glycine (3-6g)
Sunflower lecithin (3-5g)
25-300billion probiotics per day. Tons of probiotic strains so i cant give specific recommendations.
Sacharomyces Boulardii
Digestive enzymes, ox bile (has TUDCA in it) and betaine hcl w/ pepsin are good for digestion.
Phenibut (careful) (500mg-1g) (MAX ONCE PER WEEK PLEASE DO NOT USE THIS OFTEN. ITS A DRUG. Its safe if you use it rarely, but its gives nasty addiction and withdrawals if you use it often. I didnt really want to list this but its a really good anti anxiety drug. Legal and sold as a supplement. Only use if you have severe anxiety and need a tool to get something done, that you cant do without aid. Makes me feel like i did before i developed accutane mental side effects.
Those supplements, and all the nutrients are likely whats going to help the most. There is a lot of other supps but i cant recommend them generally, they are going to be either condition specific or enhancement for already healthy people.
Ive tried nearly all ingredients that exist, all these work. (Many others also work but are again mostly condition specific.)
Feel free to ask me for brands or dosages if you dont want to research stuff on your own.
Ask me about any other supplement you want.
Btw taurine is safe to supplement for up to 3g for your entire life. Higher doses then that can be useful but are not for everyday use.
Probably smart to just use 1-2g as a everyday dose.
Also guys dont get too hung up on one specific supplement. Taurine is just one of many amino acids.
First get what you can from diet with foods that work for you. (Tends to be seafood, veggies, fruit and fats. Seeds are also tolerated by some. Some probably tolerate anything but i sure dont)
Neglect stuff your body doesnt require to function until you already have a flawless diet, get all nutrients and aminos that you dont from diet etc.
Herbs and other non essential supps are good, but they are enhancers and not needed to recover or function.
http://www.ncbi.nlm.nih.gov/pubmed/20128787
Who has had their IGF tested...wonder if this continues long term.
Mike San, the IGF-1 tests are usually not accurate enough because IGF-1 could be in normal range but Binding proteins could be high too so that the active IGF-1 is low, you know what I mean. It is long term because many of us have DHEAS above the normal range (A clear sign of impairet Adrenal androgen synthesis, because most of DHEAS is metabolized in the skin to DHEA), I want not to go into deatail because its too long. But I am sure about that! Another sign that IGF-1 is low is that many people did not growth after Accutane, and have hypogonadal sympthoms. IGF-1 is a potent androgen inducer even more as testosterone. I have High SHBG too another sign of low IGF-1. But sure everyone is diffrent and I don't wanna say that I'm right with all I say. But for me and for many other people I think it is.
http://www.ncbi.nlm.nih.gov/pubmed/8344190
http://www.ncbi.nlm.nih.gov/pubmed/19709092
Natural things for us did not work I think, and milk is even inflammatory. At the point IGF-1 lowers Inflammatory cytokines like il 6 too 🙂
I would give IGF-1 a try. But it is very expensive!
There is a drug on the market called increlex