On 11/18/2015 at 4:36 AM, Modeaa said:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
In fasting state, insulin signal is weak and FoxO1 is activated by translocation into the nuclei to trigger gluconeogenesis for glucose supply. Under insulin resistance conditions, however, hyperactive FoxO1 promotes gluconeogenesis in such an uncontrolled way that it leads to hyperglycemia. It is well known that isotretinoin impairs insulin resistance.^176,177 This fact can be well explained by FoxO1-mediated upregulation of phosphoenolpyruvate carboxykinase (PEPCK), the key enzyme of gluconeogenesis.¹⁹ Thus, hyperactive FoxO1 explains impaired insulin sensitivity and an increased disposition for hyperglycemia observed under isotretinoin treatment (Fig. 4).

Interesting....

[Edited link out]
"Finally, taurine supplemented mice showed an improved IPGTT. These results indicate that taurine controls glucose homeostasis by regulating the expression of genes required for glucose-stimulated insulin secretion. In addition, taurine enhances peripheral insulin sensitivity."

Modeaa:

step 1. 11-cis-retinol dehydrogenase is also mainly associated to thesmooth endoplasmic reticulum

step 2.---->accutane destroys the endoplastic reticulum

step 3.---->"Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters.''(no place for enzyme)

step 4.----> Leading to accumulation of cis esters (accutane accumulation in all tissues associated with ER. this includes the liver and skin)

Taurine protects the endoplastic reticulum:

http://circ.ahajournals.org/content/104/10/1165.short

http://www.ncbi.nlm.nih.gov/pubmed/9635021

http://www.ncbi.nlm.nih.gov/pubmed/23392887

20 hours ago, asdfghjkl123456789 said:

On 11/15/2015, 12:19:43, AlanTookAccutaneWow said:

They really are. And when youstop and think its really such a joke were still trying fuckin suppliments. Even if we are fucked suppliments are damn dumb lol.

Shut up trying to help. Lol go back to "trying"

I agree, supplements are not helping! We are not lacking nutrients or hormones, blood tests can confirm this. We are messed up much differently, and we will never know the cause of our problem until we learn the details about how accutane works and affects us.

Right. And on this note and it destroying our lives, we really do deserve quite a bit of money. Give me my money damn it.

6 hours ago, tryingtohelp2014 said:

The reason you would need to rebalance anything imo is because of malabsorption. What you could be feeling is 10% of the vitamin A youre taking, turning something on, thats been turned off. The other 90% gets excreted, not being absorbed due to a stored metabolite in your liver, or because of a depletion in the bile salts. It also explains why you have to keep taking high amounts to feel anything. This is what the taurine might fix. Taurine has been shown to lower liver and kidney retinol levels from 80 parts to 60 parts in 6 weeks. sometimes the blood levels dont even change. i hope this starts the first in first out mechanism. i hope the drop in liver retinol levels = the metabolite being excreted.... ending the ER stress, ending the epigenetic change.

I know that you dont know, that you dont know, but you have no idea what youre typing.

5 hours ago, macleod said:

I'm with you guys. I'm gonna try out this taurine and 5-10k iu of vit A stacked with my normal routine of supps, as well as a nootropic sampler pack. I kind of hit a dead end with Tianeptine as I didn't really feel much after the first week. (tried for a month)

As far as Vit D is concerned, I generally tolerate it well, I take a pretty good amount at night with calcium and magnesium and it leads to good sleep. (I know, I try to avoid calcium because of the tendonitis) but the Vit D is advised by many doctors who see many tendon injuries and stress fractures, again which has little to do with us if we are not absorbing it properly, in any case, a full day out in the sun or taking this 500iu drop of vit D gives me a generally good feeling. To answer one of the questions above.

You will hit a dead end with all of this, guarenteed. Probably screw yourself up just a WEEEEEE bit more too.

Just true :/

-Nature

Alan, I understand you want to voice your opinion on naturopath, but the way you are going about it, harassing people, is not the way you should do it. I'm gonna have to ask the moderators to step in on this one. Because, this forum garners a lot of views, and in particular this thread, and I think we have some sort of say, if we hope to continue this threadbefore it gets out of hand.

I mayreference this website to outside people (actual doctors and scientists) and your posts actually clutter any type of information we are trying to convey. I get it, you want to come across as the quirky nature guy, but its starting to become annoyingand unproductive.

I would ask that every member of this thread throw a PM to a moderator and ask what we can do to continue this thread unharassed.

7 hours ago, macleod said:

I'm with you guys. I'm gonna try out this taurine and 5-10k iu of vit A stacked with my normal routine of supps, as well as a nootropic sampler pack. I kind of hit a dead end with Tianeptine as I didn't really feel much after the first week. (tried for a month)

As far as Vit D is concerned, I generally tolerate it well, I take a pretty good amount at night with calcium and magnesium and it leads to good sleep. (I know, I try to avoid calcium because of the tendonitis) but the Vit D is advised by many doctors who see many tendon injuries and stress fractures, again which has little to do with us if we are not absorbing it properly, in any case, a full day out in the sun or taking this 500iu drop of vit D gives me a generally good feeling. To answer one of the questions above.

I heard high doses ofvit Aplus vit D causes hypercalceamia. Please look that up before it's too late.

I unsureif taurine would help with that

vit k 2 is spose to help too

2 hours ago, trantran83333 said:

 

I heard high doses ofvit Aplus vit D causes hypercalceamia. Please look that up before it's too late.

I unsureif taurine would help with that

vit k 2 is spose to help too

No worries, I stay within the Recommended Daily Allowance of Vit D and most everything I take. I haven't tried K ever, surprisingly, but I will give it a try. Currently, I am experimenting with Ginko Biloba 24% because someone mentioned it above. I'll let you know in a month if anything of note.

42 minutes ago, Roland1968 said:

Hi all - I received my Taurine powder today and started with the supplementation. Let's see how it goes. 

Best of luck, tell us how it goes  
 

On 17 November 2015 at 11:02:56 AM, tryingtohelp2014 said:

 

I dont like the idea of anything with High vitaminA in it. The taurine youre taking should increase your natural bile acids, this will let your body absorb Vitamin A naturally from foods!! have some grass fed butter, or a pizza!

trantran... how long have your eyes been jaundiced? is this the first time youve noticed a real difference in all of that time?

 

I developed jaundice July/Augustthis year when i decided to go vegan. I went vegan because I thought it would help my liver, soon after my body couldn't tolerate meats especially red meats. I get real tired after having meats.

15 hours ago, macleod said:

No worries, I stay within the Recommended Daily Allowance of Vit D and most everything I take. I haven't tried K ever, surprisingly, but I will give it a try. Currently, I am experimenting with Ginko Biloba 24% because someone mentioned it above. I'll let you know in a month if anything of note.

K2 is like thetraffic police, tells where your calcium should go. Prevents calcification of yoursoft tissues

19 hours ago, macleod said:

Alan, I understand you want to voice your opinion on naturopath, but the way you are going about it, harassing people, is not the way you should do it. I'm gonna have to ask the moderators to step in on this one. Because, this forum garners a lot of views, and in particular this thread, and I think we have some sort of say, if we hope to continue this threadbefore it gets out of hand.

I mayreference this website to outside people (actual doctors and scientists) and your posts actually clutter any type of information we are trying to convey. I get it, you want to come across as the quirky nature guy, but its starting to become malicious and unproductive.

I would ask that every member of this thread throw a PM to a moderator and ask what we can do to continue this thread unharassed.

Macleod

11 minutes ago, AlanTookAccutaneWow said:

Yeah heard you want to voice opinions too. We all do. Its not something worth mentioning about. When youre confronted or corrected on the internet you kind of are already out of options. Lets skip this conversation and leave you with your next task at handGetting a grip.Go take your suppliments and get off my thread. The "nature guy" huh? Dismissed.

 

Wait, what are you going to do about me voicing my opinions again?

Nothing wrong with voicing your opinions. But you are taking it too personal.

If they fuck up who cares, their fault rite?

Its just that you are coming across nasty

I heard you want to voice opinions too?We all do. Its not something worth mentioning about. When youre confronted or corrected on the internet you kind of are already out of options.

So lets take what you mindlessly hatefully type toward me Macleod, and break it down.

You mentionthat you might reference this thread to a doctor, or scientist. Who are you thinking? Are you aware that bothdoctors who either know about or do not know about accutane (or other bad drugs) are not going to spend theirtime resaearching intovitamin A posioning. This is all about numbers in the FDA eyes. For example, they would look at how manypages we have VS the content, or people who submitted that YES accutane screwed them up. Mostly, they look at direct cases submitted to them. I know ive done my part there!

The nature guy? Harassment.

Me replying to your theory of supplimenting with taurine saying this is not a good idea and will (warning) probably imbalance you on an entirely different map, is however not harassment.

It is what it is my friend.

Productive or unproductive this is not your concern (nor your thread).Ive given you plenty to do and think about, nutrition wise. Do not dismiss the idea ofeating raw real, alivefoods just because you dont like me. It WILL help you recover.

Edit reason: More information

12 minutes ago, AlanTookAccutaneWow said:

I heard you want to voice opinions too?We all do. Its not something worth mentioning about. When youre confronted or corrected on the internet you kind of are already out of options.

So lets take what you mindlessly hatefully type toward me Macleod, and break it down.

You mentionthat you might reference this thread to a doctor, or scientist. Who are you thinking? Are you aware that bothdoctors who either know about or do not know about accutane (or other bad drugs) are not going to spend theirtime resaearching intovitamin A posioning. This is all about numbers in the FDA eyes. For example, they would look at how manypages we have VS the content, or people who submitted that YES accutane screwed them up. Mostly, they look at direct cases submitted to them. I know ive done my part there!

The nature guy? Harassment.

Me replying to your theory of supplimenting with taurine saying this is not a good idea and will (warning) probably imbalance you on an entirely different map, is however not harassment.

It is what it is my friend.

Productive or unproductive this is not your concern (nor your thread).Ive given you plenty to do and think about, nutrition wise. Do not dismiss the idea ofeating raw real, alivefoods just because you dont like me. It WILL help you recover.

 

Edit reason: More information

And you have done your job to warn people. I know you mean well, but should just leave it at that. Let the people decide for themselves. That way if anything happens they only have themselves to blame

3 hours ago, trantran83333 said:

 

I developed jaundice July/Augustthis year when i decided to go vegan. I went vegan because I thought it would help my liver, soon after my body couldn't tolerate meats especially red meats. I get real tired after having meats.

Then I had a conversation withthis man , he used to work in a hospital. Anyway he said this might sound contradicting but your liver needs meat for all the vitamins and amino acids to make it stronger. If you can't eat meat he said, try salt water fish or sea shells they also have amino acids

I did what he said, have fish instead. So for a while I was having salmon and barramundi, then added chicken and now I can eat red meats again. Yay

Going vegan was a bad idea!!

Sorry for late reply I was struggling to remember, have very bad memory these days

but yeh, the taurine was the only thing that I saw made a difference to the yellow in my eyes.

so in conclusion we can't get enough just from eating right but supps helps too

to all the people going crazy on vitamin A, have you thought about just one megadose once a week, to let your body adjust itself in between?

Like tryingtohelp said taurine helps with vit A absorption anyways. Just don't want anyone do the same mistake I did with the vit D. It gave me tinitus.

Vegans get 0 taurine google vegan diet and taurine. eat some eggs if you need Vitamin A. eggs also contain some taurine and choline.

and for those that are worried about supplementing taurine... over the last 10 years , we've had the biggest informal study ever on human consumption in the form of redbull , monster, nos and 5 hour energy shots sold in every store and gas station across america. if it was a problem, it wouldve been pulled from the shelves long ago.

after one week....

im already noticing my eyes are easily 75% more white (ive hadelevated bilirubin for a decade!)

stools will turn a darker color due to bile salts and better absorption. it shows the taurine is getting absorbed and is starting to work.

better digestion after eating, not as much bloat, the sour stomach which ive had for years feels much better.

feeling brain fog lift

3 hours ago, AlanTookAccutaneWow said:

I heard you want to voice opinions too?We all do. Its not something worth mentioning about. When youre confronted or corrected on the internet you kind of are already out of options.

So lets take what you mindlessly hatefully type toward me Macleod, and break it down.

You mentionthat you might reference this thread to a doctor, or scientist. Who are you thinking? Are you aware that bothdoctors who either know about or do not know about accutane (or other bad drugs) are not going to spend theirtime resaearching intovitamin A posioning. This is all about numbers in the FDA eyes. For example, they would look at how manypages we have VS the content, or people who submitted that YES accutane screwed them up. Mostly, they look at direct cases submitted to them. I know ive done my part there!

The nature guy? Harassment.

Me replying to your theory of supplimenting with taurine saying this is not a good idea and will (warning) probably imbalance you on an entirely different map, is however not harassment.

It is what it is my friend.

Productive or unproductive this is not your concern (nor your thread).Ive given you plenty to do and think about, nutrition wise. Do not dismiss the idea ofeating raw real, alivefoods just because you dont like me. It WILL help you recover.

 

Edit reason: More information

I have no feelings or emotions either way towards you. But, you are interfering with me potentially getting better or recovering. There is not one person in here that objects to natural foods and a healthy lifestyle after Accutane, for some it's the only way they can eat now. But you really can't be that dense to think supplements are of no use, or detrimental to us, even if we stay within the RDA (Recommended daily allowance). Most supplements are extracted from natural foods and plants...Which makes me believe you are just trolling on purpose, which if you know is wrong, and you continue to do it, then yes, in my eyes you are harassing people.

But, like I said, I don't think you are a bad person, and I'm willing to give you the benefit of the doubt, but let us research, even if it is by means of anecdotal trial and error. I don't need interference or criticism (unless its backed by scientific fact).

3 hours ago, tryingtohelp2014 said:

after one week....im already noticing my eyes are easily 75% more white (ive had elevated bilirubin for a decade!)

stools will turn a darker color due to bile salts and better absorption.  it shows the taurine is getting absorbed and is starting to work.

better digestion after eating, not as much bloat, the sour stomach which ive had for years feels much better.

feeling brain fog lift

 

Wow, are you serious!?  Please keep us all updated. My taurine arrives tomorrow.

How much do you take? Are you taking like 5g?

Also, can someone PM me with TUDCA supp brand recommendations? I want one that's extremely potent and absolutely devoid of fillers.

For those with jaundice of the eyes or with elevated bilirubin, why are you not experimenting with liver flushing? Jaundice is surely a sign of bile duct congestion, no?

Omg!! I just went night shopping and bought new clothes lol, something I haven't done for 8 months because I had no energy to do anything

Its 8pm here in Australia, usually I'd be in bed feeling sorry for myself, but right now I don't feel tired. I'm waiting for it to come tho..... Not that I miss it lol

hope this isn't a placebo effect

Lets hope it keeps on improving

19 hours ago, yetanotheraccutanevictim said:

Wow, are you serious!?  Please keep us all updated. My taurine arrives tomorrow.

How much do you take? Are you taking like 5g?

Also, can someone PM me with TUDCA supp brand recommendations? I want one that's extremely potent and absolutely devoid of fillers.

 

For those with jaundice of the eyes or with elevated bilirubin, why are you not experimenting with liver flushing? Jaundice is surely a sign of bile duct congestion, no?

I already tried it, it improved for like one week. And then it was back to same old... Tried it again 4 weeks after, I gagged on the lemon and olive oil mixture. Couldn't handle it. Yeh I'm a softy 

This any good? I know it's a bulk powder....

Hello

I was on accutane for 6 months and i had pretty good results. But my dry skin is still with me and also im getting acneagain wich is very annoying. It's not the most aggressive typebut it's very sustainable and Ican have a mark for weeks until i disapears. I also have some deep red marks that doesn't go away. I've been trying some different diets. I tried the low carb-high fat and my stomach got better and i got more energy but my acne went the opposite way. I was thinking about this and it came to my mind about thisoverdose of vitamin A that comes with accutane. When i cut out the carbs i replaced it with fats in cheese and protein in extra eggs. Very vitamin A-rich food. So i tried to go back to my old diet, but a smaller amount ofpasta, meat, potatoes, increasing vegetables, but excluding all vitamin A's in any form. And the next comingtwo weeks my skin improved. I've seen many others have been into this about starving out the vitamin A levels in the body that has been stored. That must be the way to go? Im planning to go for the Atkins diet now and it will be interesting to see how that goes. Anyone with experiences like me?

10 hours ago, trantran83333 said:

I already tried it, it improved for like one week. And then it was back to same old... Tried it again 4 weeks after, I gagged on the lemon and olive oil mixture. Couldn't handle it. Yeh I'm a softy 

7 minutes ago, yetanotheraccutanevictim said:

If you improved it for like one week, doesn't that make you think there is something to that??

Here is an interesting piece of information from a guy who cured himself through liver flushing. This is what he had to say (I agree):

"Theone thing about Liver Flushing that becomes apparent quite quickly

after starting to do them is that they are not a 'quick fix'. Each

one is a major milestone in recovering your health, but only after 15

liver flushes over the course of a year and a half, did I feel

'really well' most of the time. After the first one, I felt really

good for a couple of days after, and then the fog descended again.

Moritz states that this is because the Liver is congested with many,

many stones, and that within a couple of days of doing a flush, the

remaining stones move down in the liver, closer to the bile ducts and

the liver becomes clogged again, albeit now with fewer stones

inhibiting the flow of bile. Each time I did a liver flush, the

period of feeling really good lasted longer and longer, until

eventually, I didn't feel the need to do another one, and I stopped

thinking about them. The key to remember here, is that when you

start to feel the fog descend on you again, after a few days or

weeks, don't be discouraged! It is not a reason that the flush 'did

not work' or that you're 'back to square one'. Each time, it will get

better and better, until eventually there is nothing left to clean

out and the body can fully repair itself."

Also, thanks for the TUDCA brand recommendation.Will research into it when I get a little bit more eye moisture..

Sidenote: Taurine arrived today. Starting with 1,000mg per day on an empty stomach.Brand I chose is Pure Encapsulations.

For maximum absorption, should we take it on an empty stomach or would it be better sublingually? Any thoughts?

Hey I was thinkingthe same, I usually take it before meals but yesterday I took it after meals for a change and my bowel movements weren't as good this morning.

Ok then,you talked me into doing another flush. That lemon and olive oil tho haha

Got some taurine and a nootropic sampler coming in the mail this Saturday. Pretty stoked. Powder city is one hell of a site, they are UK based but have distribution centers world wide. I'll keep everyone updated on my trials.

I just shucked some oysters and ate them raw. It was so yummy!

Anyways I heard lolaccutane mention that it was good for omega 3 absorbtion.

i noticed not many on here mention about omega 3. He/she said raw DHA omega 3 insulates the cells so they don't short circuit.

just wanna share....

any thoughts?

Tran I just got 250g taurine from Bulk Nutrients and it came today! Are you still taking it or just the TUDCA?

6 minutes ago, Mike San said:

Tran I just got 250g taurine from Bulk Nutrients and it came today! Are you still taking it? Your eyes improved a lot.

 

 

Thanks, it has improved maybe 85%, redness almost gone too. Still get pretty pinkishat night time tho, around 9-10pm. I take like 2 grams a day now, 1 teaspoon divided throughout the day. I'm too scared I might OD.

The more i read, the more excited i get. I honestly think we found the root cause. Accutane depletes taurine both directly (by using up taurine to conjugate excessive retinoids) and indirectly (by activating the GNMT enzyme, depleting methionine, which is used to make Taurine in the body.) Its also important to take P5P (B6) .. this activates your bodies other pathway to make it naturally. wow what a full circle this has become. Everything i read says 1 gram, up to 6 grams, as a therapeutic dose.

Read everything about BrdUrd-positive cells:

13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice

http://www.pnas.org/content/101/14/5111.full.pdf

vs.

Taurine increases hippocampal neurogenesis in aging mice

http://www.sciencedirect.com/science/article/pii/S1873506115000434

http://www.ncbi.nlm.nih.gov/pubmed/22484511

http://www.lifeextension.com/magazine/2015/9/grow-new-brain-cells/page-01