For those withseborrheic dermatitis, as well as the myriad of other problems, try sea salt.It really helps with the flaky, dry skin.

Sea salt. To the store tryingtohelp.

Can someone please tell me why vitamin D is not advised for people who have taken Accutane?
I have personally tried taking vitamin D several times and it has increased the inflammation in my body every time, so I'm reluctant to ever try it again.
Have others had the same experience with vitamin D?

When I first started taking it I actually dried out more, but then after a week itgot noticeablyworse.
These last few days when I forgot my to bring some when I went to my parentsfarmhouse, the skin dried a fair bit and my acne went away a bit, sonow it is in the period I stop that I get some of the accutane sides(as in when you are on it, dry skin/lips, nosebleeds, etc),

However, I have also been running and gyming these last few months, and today I benched 220lb for the first time, as well as deadlifted 380lb, and the joint pain I got when I was on accutane isnt there, even though I am pushing my body pretty hard

Current "stack"
Vitamin A 50-100k IU per day, though I just had a 4 day hiatus, and have had 200k IU today to catch up
Vitamin D 2-5k IU per day, but been getting plenty of sun as well, feel free to up it
Zinc
Fish Oil
Avoiding excess amounts of sugar in general as well, for general health rather than anything accutane related

Hypercalcemia can also be caused by hypervitminosis D, as well as hypervitminosis A. Though for different reasons.

Hypervitaminosis A increases bone turnover rates, so it encourages the absorption of the calcium into your blood stream, whilst preventing the repairing of bones 
https://en.wikipedia.org/wiki/Vitamin_A#Toxicity  
"High vitamin A intake has been associated with spontaneous bone fractures in animals. Cell culture studies have linked increased bone resorption and decreased bone formation with high intakes. This interaction may occur because vitamins A and D may compete for the same receptor and then interact with parathyroid hormone, which regulates calcium.^[57] Indeed, a study by Forsmo et al. shows a correlation between low bone mineral density and too high intake of vitamin A.^[62] Sufficiently high levels of vitamin D may be protective against the bone density lowering effects of high vitamin A, while inadequate levels of vitamin D may exacerbate those effects"

Hypervitaminosis D improves your bodies efficiency in metabolizing available calcium, while doing nothing to inhibit the construction and lowering the turnover rate. Interestingly this sounds like what is happening in our bodies, as we have excess calcification in soft-tissue. However, we may not even have extremely high levels of Vitamin D, however, because we have very low levels of vitamin A/ our vitamin A is metabolized inefficiently due to our "theraputic acne treatment" with 1mg/kg/day of Isotretinoin, even normal/low levels of Vitamin D can cause symptoms of vitamin D can cause vitamin D toxicity
https://en.wikipedia.org/wiki/Vitamin_D
"An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. In addition, hypertension can result"

Also interesting are the links between vitamin A
"VAD affects vision by inhibiting the production of rhodopsin, the eye pigment responsible for sensing low light situations. Rhodopsin is found in the retina and is composed of retinal (an active form of vitamin A) and opsin (a protein). Because the body cannot create retinal in sufficient amounts, a diet low in vitamin A will lead to a decreased amount of rhodopsin in the eye, as there is inadequate retinal to bind with opsin. Night blindness results."

It looks like without a doubt taurine, and the other proteins, may be very useful for reducing the long term sides of Accutane, thus next year I plan to take it, along with creatine and other supplements. Perhaps due to the reduced/changed metabolism of vitamin A, our body began sourcing out taurine to cover some of the deficits of said reduced/changed metabolism of vitamin A.
However, I remain firm in my belief that the root cause is due to the way our body processes vitamin A,  and I think much of our symptoms can be deduced to Vitamin A toxicity/deficiency due after megadosing Isotretinoin, our body changed the way it metabolised vitamin A and its derivatives, and secondary effects of this could be the subsequent Vitamin D toxicity/deficiency...
but I will take that dive myself and continue my updates over coming weeks/months.

Relevent article, says that taurine can reduce the effects of vitamin A toxicity in rats
http://www.sciencedirect.com/science/article/pii/S0308814607005420
" However, these toxic effects of vitamin A were significantly reduced when the rats were fed the diet with the supplement of taurine. Furthermore, the level of vitamin A in the serum of rats treated with taurine and vitamin A was higher than that of rats treated with vitamin A alone. This indicated that taurine might play a role in reducing the toxic effect of vitamin A in rats."
On the off chance I am wrong, and Taurine is a root cause, this is interesting because that indicates it may improve regulation of vitamin A... May consider adding it sooner to my stack
Would be interested to see how vitamin A consumption affects natural Taurine production, and whether the depletion of Taurine post-Accutane is due to the body using it to compensate for the fact that it has trouble metabolising Vitamin A properly...Or maybe metabolising the Isotretinoin trying to get rid of that? Food for Thought

TL:DR; Sounds like Taurine supplementation could be very useful in reducing Accutane sides(maybe by a lot), as well as other mentioned proteins coiuld help as well (may be more relevent to Prospecia sufferers).
However, I personally feel the metabolism of Vitamin A is messed up by Accutane, and thus am currently having large doses of Vitamin A seeing if helps (so far yes), though it seems Taurine Supplementation could only HELP with my cause as well, thus recommend Taurine to those who may try what I am doing

You are right in this i think, but i believe it changed our ability to both catabolize and absorb Vitamin A correctly. every single side effect can almost be traced back to this Methyl/Taurine problem it seems... like i posted before.

It been documented that GNMT stays upregulated after discontinuing accutane... why? Here is a picture of the pathway to make Taurine in the body...we can bypass this entire process by taking taurine direct:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513970/figure/Fig1/

Accutane stops step one by eliminating methionine/folate!! This is 1000% documented over and over. Accutane has reduced us to being felines, we cant manufacture it ourselves. NAC works in detox by being halfway down the taurine pathway.

Taurine protects Rhodopsin

Taurine is a calcium regulator for Hypercalcemia

this could explain why Vitamin D hurts some people who are taurine deficient.

I would strongly advise anyone on here to start taking 5 grams of taurine daily for 6 weeks.

This even can have ties to the finasteride/propecia people......

https://books.google.com/books?id=mDBfkK-XmfgC&pg=PA90&lpg=PA90&dq=taurine+and+pregnenolone&source=bl&ots=bFxRLwYo-F&sig=ew7jQbuIh6a5acgUbhVnzbRpM6o&hl=en&sa=X&ved=0CEoQ6AEwBmoVChMI39Oj6-6UyQIVjOkmCh0G9Q0m#v=onepage&q=taurine and pregnenolone&f=false

All steriods are derived from pregnenolone---> pregnenolone is cleaved off of cholesterol along with bile acids comprised of taurine and glycine. 5-AR is just down this metabolic pathway.

read this postabout polymorphisms and possible finasteride accumulations in the liver and tell me it doesnt sound exactly what could be happening to us:

http://forums.phoenixrising.me/index.php?threads/23andme-chronic-insomnia-and-family-history-of-psychiatric-cns-disorders.28189/page-7

Everyone who is going to try TUDCA please share us how it works on you.

7 hours ago, Fchawk said:

Hypercalcemia can also be caused by hypervitminosis D, as well as hypervitminosis A. Though for different reasons.

Hypervitaminosis A increases bone turnover rates, so it encourages the absorption of the calcium into your blood stream, whilst preventing the repairing of bones 
https://en.wikipedia.org/wiki/Vitamin_A#Toxicity  
"High vitamin A intake has been associated with spontaneous bone fractures in animals. Cell culture studies have linked increased bone resorption and decreased bone formation with high intakes. This interaction may occur because vitamins A and D may compete for the same receptor and then interact with parathyroid hormone, which regulates calcium.^[57] Indeed, a study by Forsmo et al. shows a correlation between low bone mineral density and too high intake of vitamin A.^[62] Sufficiently high levels of vitamin D may be protective against the bone density lowering effects of high vitamin A, while inadequate levels of vitamin D may exacerbate those effects"

Hypervitaminosis D improves your bodies efficiency in metabolizing available calcium, while doing nothing to inhibit the construction and lowering the turnover rate. Interestingly this sounds like what is happening in our bodies, as we have excess calcification in soft-tissue. However, we may not even have extremely high levels of Vitamin D, however, because we have very low levels of vitamin A/ our vitamin A is metabolized inefficiently due to our "theraputic acne treatment" with 1mg/kg/day of Isotretinoin, even normal/low levels of Vitamin D can cause symptoms of vitamin D can cause vitamin D toxicity
https://en.wikipedia.org/wiki/Vitamin_D
"An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. In addition, hypertension can result"

Also interesting are the links between vitamin A
"VAD affects vision by inhibiting the production of rhodopsin, the eye pigment responsible for sensing low light situations. Rhodopsin is found in the retina and is composed of retinal (an active form of vitamin A) and opsin (a protein). Because the body cannot create retinal in sufficient amounts, a diet low in vitamin A will lead to a decreased amount of rhodopsin in the eye, as there is inadequate retinal to bind with opsin. Night blindness results."

It looks like without a doubt taurine, and the other proteins, may be very useful for reducing the long term sides of Accutane, thus next year I plan to take it, along with creatine and other supplements. Perhaps due to the reduced/changed metabolism of vitamin A, our body began sourcing out taurine to cover some of the deficits of said reduced/changed metabolism of vitamin A.
However, I remain firm in my belief that the root cause is due to the way our body processes vitamin A,  and I think much of our symptoms can be deduced to Vitamin A toxicity/deficiency due after megadosing Isotretinoin, our body changed the way it metabolised vitamin A and its derivatives, and secondary effects of this could be the subsequent Vitamin D toxicity/deficiency...
but I will take that dive myself and continue my updates over coming weeks/months.
Relevent article, says that taurine can reduce the effects of vitamin A toxicity in rats
http://www.sciencedirect.com/science/article/pii/S0308814607005420
" However, these toxic effects of vitamin A were significantly reduced when the rats were fed the diet with the supplement of taurine. Furthermore, the level of vitamin A in the serum of rats treated with taurine and vitamin A was higher than that of rats treated with vitamin A alone. This indicated that taurine might play a role in reducing the toxic effect of vitamin A in rats."
On the off chance I am wrong, and Taurine is a root cause, this is interesting because that indicates it may improve regulation of vitamin A... May consider adding it sooner to my stack
Would be interested to see how vitamin A consumption affects natural Taurine production, and whether the depletion of Taurine post-Accutane is due to the body using it to compensate for the fact that it has trouble metabolising Vitamin A properly...Or maybe metabolising the Isotretinoin trying to get rid of that? Food for Thought

TL:DR; Sounds like Taurine supplementation could be very useful in reducing Accutane sides(maybe by a lot), as well as other mentioned proteins coiuld help as well (may be more relevent to Prospecia sufferers).
However, I personally feel the metabolism of Vitamin A is messed up by Accutane, and thus am currently having large doses of Vitamin A seeing if helps (so far yes), though it seems Taurine Supplementation could only HELP with my cause as well, thus recommend Taurine to those who may try what I am doing

 

Nice post, I agree with you on the theory that our Vitamin A metabolism is screwed up.
Though I'm supplementing lower doses but more diverse forms of Vitamin A. ( Liver - Beta Carotene, Lutein - Rentinyl Palmitate )
 

11 minutes ago, Kokodu said:

Everyone who is going to try TUDCA please share us how it works on you.

The TUDCA for me reduced my bloating significantly and I'm processing foods again. 
I'm pooping perfectly brown stools.
Though I'm also drinking alot of buttermilk for the probiotics.

I'm interested how other people react to it. 

It seems since the gastrointestinal tract is screwed up our bodies may not produce enough serotonin. Is there a way to reverse this or fix the tract so it can hopefully restore serotonin to normal levels and hopefully cure the accutane caused depression? For me this is the most debilitating and troubling thing about my situation. I'm so desperate at this point. Ssri don't seem to be the answer.

1 hour ago, Walden Rev said:

The TUDCA for me reduced my bloating significantly and I'm processing foods again.
I'm pooping perfectly brown stools.
Though I'm also drinking alot of buttermilk for the probiotics.

Interesting. If you are slim so can you check how efficient it is to gain weight?

taurine has also been shown to counteract wasting away in patients treated w chemotherapy drugs---obviously relative to accutane.

My only concern is I hope this isn't just another promising thing that ends up being a waste that this thread as seen too many times. It happened with manganese, cannabis, and other things. People talk about something for a good 2 months, and then it dies down bc it wasn't too beneficial. Whatever, i'll be trying taurine. Cheap and can't hurt.

nevermind the tag. On my phone and don't know how to delete it. 

Like ke I said so many times before I have blood shot red eyes and jaundice in my eyes.
taking taurine for nearly one week now.
first photo is two days after taurine and last is today. Can you see a difference?

There is still a little yellow in the corner of my eye, but that's about it not all over like before. 
Taking TUDCA, taurine, magnesium, glycine, b2 and k2
Just wanted to share

19 minutes ago, trantran83333 said:

nevermind the tag. On my phone and don't know how to delete it.
Like ke I said so many times before I have blood shot red eyes and jaundice in my eyes.
taking taurine for nearly one week now.
first photo is two days after taurine and last is today. Can you see a difference?

so happy for you, give it 6 weeks, and see if other symptoms start to improve. ive noticed the jaundice going away as well. how much are you taking?

I started of with half a teaspoon a day, now it's half a teaspoon 3 times a day
what dose would you recommend?
I have no idea how many grams half a teaspoon is

Half a teaspoon will be about 1 gram.

I've just got some taurine powder and it says on the back 1 gram is approx 1/6 of a tablespoon, and generally 1 teaspoon is considered to be about 1/3 of a tablespoon, so 1/2 a teaspoon will be about 1 gram!

I'm going to restart the tudca later this week, and I'm planning to add taurine to the regime. I'm particularly interested in using night vision as a gauge as to whether it's having an effect, as my night vision post tane is basically zero, so even a slight improvement will be noticeable.

Been thinking about the high doses of natural vitamin A people have been trying (i.e. as opposed to synthetic vit A like isotretinoin) and I've read somewhere before that RSO (rick simpson oil) is very high in vitamin A as it's essentially pretty much just concentrated 'leafy greens' (most of the dietary fibre and water content removed). There are 3 documented recoveries on this thread from people taking RSO, one of which also involved taking cod-liver oil, so maybe the Vit A is potentially overlooked factor in these. Taking tudca/taurine along with a fairly high intake of natural vitamin A is something I'll consider trying.

47 minutes ago, tanedout said:

Half a teaspoon will be about 1 gram.

I've just got some taurine powder and it says on the back 1 gram is approx 1/6 of a tablespoon, and generally 1 teaspoon is considered to be about 1/3 of a tablespoon, so 1/2 a teaspoon will be about 1 gram!

I'm going to restart the tudca later this week, and I'm planning to add taurine to the regime. I'm particularly interested in using night vision as a gauge as to whether it's having an effect, as my night vision post tane is basically zero, so even a slight improvement will be noticeable.

Been thinking about the high doses of natural vitamin A people have been trying (i.e. as opposed to synthetic vit A like isotretinoin) and I've read somewhere before that RSO (rick simpson oil) is very high in vitamin A as it's essentially pretty much just concentrated 'leafy greens' (most of the dietary fibre and water content removed). There are 3 documented recoveries on this thread from people taking RSO, one of which also involved taking cod-liver oil, so maybe the Vit A is potentially overlooked factor in these. Taking tudca/taurine along with a fairly high intake of natural vitamin A is something I'll consider trying.

I dont like the idea of anything with High vitaminA in it. The taurine youre taking should increase your natural bile acids, this will let your body absorb Vitamin A naturally from foods!! have some grass fed butter, or a pizza!

trantran... how long have your eyes been jaundiced? is this the first time youve noticed a real difference in all of that time?

On November 15, 2015 at 12:19:43 PM, AlanTookAccutaneWow said:

They really are. And when youstop and think its really such a joke were still trying fuckin suppliments. Even if we are fucked suppliments are damn dumb lol.

Shut up trying to help. Lol go back to "trying"

I agree, supplements are not helping! We are not lacking nutrients or hormones, blood tests can confirm this. We are messed up much differently, and we will never know the cause of our problem until we learn the details about how accutane works and affects us.

On 13/11/2015 1:02:48, trantran83333 said:

Ok I just got Glycine powder gonna team it with taurine powder and consuming organic lamb liver.

Not sure about the TUDCA I got tho, it is in a capsule form. The other ingredients in it were rice flour and magnesium stearate

does anybody know if it would make a difference, powder or capsule???

Why would you want to eat lamb liver or any other liver for that matter? It is so high in retinol, that eating it would be like taking Accutane all over again, at least in my opinion!

7 minutes ago, Accutainted4ever said:

Why would you want to eat lamb liver or any other liver for that matter? It is so high in retinol, that eating it would be like taking Accutane all over again, at least in my opinion!

Hey i have low semen volume for 1 years.
I used only 100mg of accutane . (5 pills , 4 days)
and then i stopped because my semen volume problem.
Its still not gone ?
what is my problem ?
help me.. (also you can check my own topic for more detail. Its in this forum )

3 hours ago, Accutainted4ever said:

Why would you want to eat lamb liver or any other liver for that matter? It is so high in retinol, that eating it would be like taking Accutane all over again, at least in my opinion!

The reason is that we are hoping to re-balance the levels of differing retinols we have in our body, so our body can begin metabolising Vitamin A properly and start functioning normally again.
In the past 3 weeks I would have had 2.25 million IU of Vitamin A, as well as maybe 75,000 IU of Vitamin D. I can honestly say I feel very good, never felt better in fact (post-accutane that is), though that said the side effects I had from Isotretinoin aren't as large as many of the people on this forum. I would have been at 87% trying to get back up to 95-100%, and now I feel 90% so far, and happy with that progress, while many people here might be anywhere from 50-75%.
People who process Vitamin A normally (haven't been on accutane) could be having 2 times as much vitamin Aper kg of bodyweight as I've been having daily, for years before they begin to experience chronic toxicity, so the dosage I am having should be safe almost indefinitely, though I do plan to eventually lower or stop supplementing entirely if I feel my body has fully recovered. #optimist

6 hours ago, Fchawk said:

The reason is that we are hoping to re-balance the levels of differing retinols we have in our body, so our body can begin metabolising Vitamin A properly and start functioning normally again.
In the past 3 weeks I would have had 2.25 million IU of Vitamin A, as well as maybe 75,000 IU of Vitamin D. I can honestly say I feel very good, never felt better in fact (post-accutane that is), though that said the side effects I had from Isotretinoin aren't as large as many of the people on this forum. I would have been at 87% trying to get back up to 95-100%, and now I feel 90% so far, and happy with that progress, while many people here might be anywhere from 50-75%.
People who process Vitamin A normally (haven't been on accutane) could be having 2 times as much vitamin Aper kg of bodyweight as I've been having daily, for years before they begin to experience chronic toxicity, so the dosage I am having should be safe almost indefinitely, though I do plan to eventually lower or stop supplementing entirely if I feel my body has fully recovered. #optimist

The reason you would need to rebalance anything imo is because of malabsorption. What you could be feeling is 10% of the vitamin A youre taking, turning something on, thats been turned off. The other 90% gets excreted, not being absorbed due to a stored metabolite in your liver, or because of a depletion in the bile salts. It also explains why you have to keep taking high amounts to feel anything. This is what the taurine might fix. Taurine has been shown to lower liver and kidney retinol levels from 80 parts to 60 parts in 6 weeks. sometimes the blood levels dont even change. i hope this starts the first in first out mechanism. i hope the drop in liver retinol levels = the metabolite being excreted.... ending the ER stress, ending the epigenetic change.

I'm with you guys. I'm gonna try out this taurine and 5-10k iu of vit A stacked with my normal routine of supps, as well as a nootropic sampler pack. I kind of hit a dead end with Tianeptine as I didn't really feel much after the first week. (tried for a month)

As far as Vit D is concerned, I generally tolerate it well, I take a pretty good amount at night with calcium and magnesium and it leads to good sleep. (I know, I try to avoid calcium because of the tendonitis) but the Vit D is advised by many doctors who see many tendon injuries and stress fractures, again which has little to do with us if we are not absorbing it properly, in any case, a full day out in the sun or taking this 500iu drop of vit D gives me a generally good feeling. To answer one of the questions above.

27 minutes ago, tryingtohelp2014 said:

The reason you would need to rebalance anything imo is because of malabsorption. What you could be feeling is 10% of the vitamin A youre taking, turning something on, thats been turned off. The other 90% gets excreted, not being absorbed due to a stored metabolite in your liver, or because of a depletion in the bile salts. It also explains why you have to keep taking high amounts to feel anything. This is what the taurine might fix. Taurine has been shown to lower liver and kidney retinol levels from 80 parts to 60 parts in 6 weeks. sometimes the blood levels dont even change. i hope this starts the first in first out mechanism. i hope the drop in liver retinol levels = the metabolite being excreted.... ending the ER stress, ending the epigenetic change.

Yes and yes. This sounds like a great theory and we all should follow different paths for the greater good. I fully support you.

I do however believe our bodies learned to deal with the "stored"accutane in our bodies and thats whyI want to do the accutane course with the true Vitamin A. In addition I'm using TUDCA and Taurine ( differenttiming ) to help the detox pathways.

I will keep with this protocol for some months and maybe take some supplement vacations in between and see how my body is reacting without any supplements.

Again I full support you and you are doing a f*cking great job with your research, but I do think supplementing true Vitamin A is key.

I hope one of us is right!

- Wald

10 hours ago, Accutainted4ever said:

Why would you want to eat lamb liver or any other liver for that matter? It is so high in retinol, that eating it would be like taking Accutane all over again, at least in my opinion!

10 hours ago, Accutainted4ever said:

Why would you want to eat lamb liver or any other liver for that matter? It is so high in retinol, that eating it would be like taking Accutane all over again, at least in my opinion!

Hey, I think I figured they out the hard way lol. My body did not like it at all.

Think I will stick to plant based vit A