Propecia and Accutane both inhibit 5ar, but IMO they do it by different mechanisms.
I've heard people having boron and other things to help 5ar, and creatine to help DHT, but I think that accutane sufferers suffer due to a vitamin imbalance, and subsequent changes in how the body metabolises vitamins caused by such large doses of Accutane. In a way I think we accutane side sufferers have a better chance of getting to the root cause of our problems, though it may be easier for propecia sufferers to get rid of their sides. I could be very wrong though, I've spent much more time looking at Accutane
Hey i took accutane for 4 days , and i stopped for huge semen volume decrease. 1 year passed , i have still the problem.
My semen is still low , i dont know what to do ? what is my problem !!
Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.
I get and am also sick of living this way.Despite all of the efforts in the thread nothing adds up to a can of beans with any of it being correct. All we know at this point is that going to the doctor, or messing with things moremight not be the answer, and instead eating true, caveman style meals and food might restore our health over a long period of time. I have seen inprovements, but its not hard for it to be expected with the kind of raw shit i eat LOL. Ive also found a lot of power with fasting. I dont want to be spiritual with you now but if you try it message me. I am about to start another 3 day fast, which is enough for me, about twice a month. Dont fall into the supplimentation talk,of adding more, if anything in a way us accutaners simply need less. Do you have more symptoms to share? Stomach pains or malfunctions?
like I said I have never tried supplementing on amino acids before so I can't really comment on that, but the Chinese herbs my herbalist gave me really helped with my mood.
The reason I'm trying the acids now is to try and cure my sore red eyes, jaundice in my eyes and night blindness. It is so very irritating.
I feel there is an imbalance in my body.
most of the amino acids are found in
beef, chicken orlamb liver, and vitamins like zinc are found in mussels and oysters.
Just google their nutrition values,
maybe I will try to get what I need through real foods instead because the supplements aren't working that well for me. Or maybe it's the case of you will feel worse before you get better (detox) effect. I dunno, 3 years suffering and still in search of an answer.
Considering going to to a hypnotherapist to quit my smokes. I think that may help half the problems I have. Just thinking out loud now lol
stop taking those antidepressants or whatever the doc gave you. They are just a bandage/ mask cover up. Go treat the root cause. It is your liver.... Good luck
also stay away from deep fried foods your liver won't like it. It's either raw steam or boil with me nowadays, plain,bland and boring but the liver is thanking you for it.
a tip I got from my herbalist
AKA - caveman style food lol
Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.
my Chinese herbalist once explained that anger, anxiety and depression are cause my your liver not working as it should.
in my case roaccutane damaged my liver.
I lost my relationship and my best friend due to depression and anger. I'd say the liver is the cause, I would look into it if I were youI was exactly the same as you, I would cry for no reason. Get angry at little petty things. I was going crazy. I wasn't..... ME!
vit D and magnesium helped but I reckon the Chinese medicineare what improvedmy mental state.
I say go find a good Chinese herbalistholy shit, i just read something about "Angry Liver" I really think im on to something. It ties into a lot ofsymptomsespeciallywith bile flow, TEWL, GNMT, braincells, night blindness, dopamine etc. I cant believe i didnt see this before. its actually pretty simple when you think about it.
accutane upregulates GNMT throwing off our methyl groups. A highly upregulated GNMT depletes methionoine, which in turn depletes TAURINE indirectly by not having the substrate for our bodies to manufature it. Taurine is also needed for fattyacidsynthesis. Taurine keeps the bile liquid preventing Cholestasis.
Glyine and Taurine are the two bile salt conjugates. Accutane gets detoxified by two different ways, 1. through glucurondination, 2. throughtaurine conjugation?!
http://cot.food.gov.uk/sites/default/files/cot/cotstavita.pdf 19. Vitamin A and derivative compounds can be conjugated in the liver with glucuronic acid or taurine (EVM, 2003; IOM, 2001). as always, follow the money:
http://www.google.com/patents/US4545977 Osmolytes seem to be a big thread in this... they basically introduce water back into the cells that accutane literally dries out.
I keep coming back to the thing we know is true. When your skin dries out from a drug, dry air, or UV radiation... it tries to protect itself with fatty acids and taurine!
http://www.ncbi.nlm.nih.gov/pubmed/1941178 Now it explains here, that accutane (CRA) can be used for methionine toxicity. so wouldnt the opposite be true? wouldnt taking methionine or its ultimate end product taurine help? This is what throws off our SAM/SAH ratio, and why taking methylfolate doesnt seem to help. maybe this is why TUDCA helps maybe this is why the guy cured himself eating nothing but scallops (very high in taurine) and rice. maybe this is why ketogenic diets help (meats are sources of methionine)
Bile acids and Vitamin A homeostasis
http://www.rug.nl/research/portal/files/3677919/08_diss.pdf Im focusing on the symptoms and everything needed to eliminate the metabolites.
so far:
Manganese
Glycine
TAURINE
Magnesium
b6 (P5P)
betaine trimethylglycineget a bulk powder form of Taurine from amazon. take 1.5-2 grams to start in divided does.
http://www.nap.edu/read/1349/chapter/8#79 Retinol circulates in the blood as a 1: 1:1 trimolecular complex with retinol-binding protein (RBP) and transthyretin (TTR) (Goodman, 1984a). RBP is released from the liver in combination with retinol, and the holo-RBP complex combines with TTR in the blood. Subsequently, retinol is slowly metabolized in the liver to numerous products, some of which are conjugated with glucuronic acid or taurine, and eliminated in the bile (Sporn et al., 1984). Of the total retinol metabolized, approximately 70% of the metabolic products appear in the feces and 30% are excreted in the urine. Almost all these excreted products are biologically inactive metabolites. For a more detailed review of retinol metabolism, see Goodman and Blaner (1984).
Night blindness:
Taurine supports the integrity of photoreceptors necessary for night vision2, 3, in a process known as rhodopsin regeneration. Rhodopsin is the primary pigment in photoreceptor rods and so vision in low-light conditions is supported. It also helps to protect cell membranes from free radical damage and helps to remove toxins and debris.4Taurine is found in the photoreceptors at levels ten times greater than other amino acids.5
TEWL andproteinmis-folding
http://www.in-cosmetics.com/RXUK/RXUK_InCosmetics/2015-Website/Documents/in-cos15, IS, T3,D3, Unlock the power of nature, Piera M. Pericu.pdf?v=635664145578959704
Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.my Chinese herbalist once explained that anger, anxiety and depression are cause my your liver not working as it should.
in my case roaccutane damaged my liver.
I lost my relationship and my best friend due to depression and anger. I'd say the liver is the cause, I would look into it if I were youI was exactly the same as you, I would cry for no reason. Get angry at little petty things. I was going crazy. I wasn't..... ME!
vit D and magnesium helped but I reckon the Chinese medicineare what improvedmy mental state.
I say go find a good Chinese herbalistholy shit, i just read something about "Angry Liver" I really think im on to something. It ties into a lot ofsymptomsespeciallywith bile flow, TEWL, GNMT, braincells, night blindness, dopamine etc. I cant believe i didnt see this before. its actually pretty simple when you think about it.
accutane upregulates GNMT throwing off our methyl groups. A highly upregulated GNMT depletes methionoine, which in turn depletes TAURINE indirectly by not having the substrate for our bodies to manufature it. Taurine is also needed for fattyacidsynthesis. Taurine keeps the bile liquid preventing Cholestasis.
Glyine and Taurine are the two bile salt conjugates. Accutane gets detoxified by two different ways, 1. through glucurondination, 2. throughtaurine conjugation?!
http://cot.food.gov.uk/sites/default/files/cot/cotstavita.pdf 19. Vitamin A and derivative compounds can be conjugated in the liver with glucuronic acid or taurine (EVM, 2003; IOM, 2001). as always, follow the money:
http://www.google.com/patents/US4545977 Osmolytes seem to be a big thread in this... they basically introduce water back into the cells that accutane literally dries out.
I keep coming back to the thing we know is true. When your skin dries out from a drug, dry air, or UV radiation... it tries to protect itself with fatty acids and taurine!
http://www.ncbi.nlm.nih.gov/pubmed/1941178 Now it explains here, that accutane (CRA) can be used for methionine toxicity. so wouldnt the opposite be true? wouldnt taking methionine or its ultimate end product taurine help? This is what throws off our SAM/SAH ratio, and why taking methylfolate doesnt seem to help. maybe this is why TUDCA helps maybe this is why the guy cured himself eating nothing but scallops (very high in taurine) and rice. maybe this is why ketogenic diets help (meats are sources of methionine)
Bile acids and Vitamin A homeostasis
http://www.rug.nl/research/portal/files/3677919/08_diss.pdf Im focusing on the symptoms and everything needed to eliminate the metabolites.
so far:
Manganese
Glycine
TAURINE
Magnesium
b6 (P5P)
betaine trimethylglycineget a bulk powder form of Taurine from amazon. take 1.5-2 grams to start in divided does.
http://www.nap.edu/read/1349/chapter/8#79 Retinol circulates in the blood as a 1: 1:1 trimolecular complex with retinol-binding protein (RBP) and transthyretin (TTR) (Goodman, 1984a). RBP is released from the liver in combination with retinol, and the holo-RBP complex combines with TTR in the blood. Subsequently, retinol is slowly metabolized in the liver to numerous products, some of which are conjugated with glucuronic acid or taurine, and eliminated in the bile (Sporn et al., 1984). Of the total retinol metabolized, approximately 70% of the metabolic products appear in the feces and 30% are excreted in the urine. Almost all these excreted products are biologically inactive metabolites. For a more detailed review of retinol metabolism, see Goodman and Blaner (1984).
Night blindness:
Taurine supports the integrity of photoreceptors necessary for night vision2, 3, in a process known as rhodopsin regeneration. Rhodopsin is the primary pigment in photoreceptor rods and so vision in low-light conditions is supported. It also helps to protect cell membranes from free radical damage and helps to remove toxins and debris.4Taurine is found in the photoreceptors at levels ten times greater than other amino acids.5
TEWL andproteinmis-folding
http://www.in-cosmetics.com/RXUK/RXUK_InCosmetics/2015-Website/Documents/in-cos15, IS, T3,D3, Unlock the power of nature, Piera M. Pericu.pdf?v=635664145578959704
Excellent finds TTH2014! Particularly about taurine playing such an important part in night vision. I'd not read this before (or may have just overlooked it), but it gives me more weight to a lot of your recent theory. I'm going to get hold of some to supplement.
Interestingly one of the most effective things I've found for tane sides is actually pumpkin seeds (for mental clarity especially), and these are a good source of a few of the minerals youmention - magnesium, zinc andmanganese. I've tried supplementing all these things individually, but with less results than I get from eating only 50g of seeds per day. I actuallystopped eating these for some time as they are supposed to be a 5AR inhibitor, but reading into this in more detail it appears they do reduce DHT, but via a different mechanism to 5ARinhibition.
Have recently come off TUDCA after taking600mg daily for 5-6 weeks (along with active B6, B12, folic acid, D3, selenium) as I was starting to feel a bit sh1t on it, and was getting pains in my liver (under right rib) just like I did when I'd come off tane. Having stopped it I feel fine again -probably a bit better than before even with better mental clarity. I'm not sure if I wasbecoming depleted in something on that regime,butwill restart in a few weeks and add taurine and glycine!
Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.
my Chinese herbalist once explained that anger, anxiety and depression are cause my your liver not working as it should.
in my case roaccutane damaged my liver.
I lost my relationship and my best friend due to depression and anger. I'd say the liver is the cause, I would look into it if I were youI was exactly the same as you, I would cry for no reason. Get angry at little petty things. I was going crazy. I wasn't..... ME!
vit D and magnesium helped but I reckon the Chinese medicineare what improvedmy mental state.
I say go find a good Chinese herbalistholy shit, i just read something about "Angry Liver" I really think im on to something. It ties into a lot ofsymptomsespeciallywith bile flow, TEWL, GNMT, braincells, night blindness, dopamine etc. I cant believe i didnt see this before. its actually pretty simple when you think about it.
accutane upregulates GNMT throwing off our methyl groups. A highly upregulated GNMT depletes methionoine, which in turn depletes TAURINE indirectly by not having the substrate for our bodies to manufature it. Taurine is also needed for fattyacidsynthesis. Taurine keeps the bile liquid preventing Cholestasis.
Glyine and Taurine are the two bile salt conjugates. Accutane gets detoxified by two different ways, 1. through glucurondination, 2. throughtaurine conjugation?!
http://cot.food.gov.uk/sites/default/files/cot/cotstavita.pdf 19. Vitamin A and derivative compounds can be conjugated in the liver with glucuronic acid or taurine (EVM, 2003; IOM, 2001). as always, follow the money:
http://www.google.com/patents/US4545977 Osmolytes seem to be a big thread in this... they basically introduce water back into the cells that accutane literally dries out.
I keep coming back to the thing we know is true. When your skin dries out from a drug, dry air, or UV radiation... it tries to protect itself with fatty acids and taurine!
http://www.ncbi.nlm.nih.gov/pubmed/1941178 Now it explains here, that accutane (CRA) can be used for methionine toxicity. so wouldnt the opposite be true? wouldnt taking methionine or its ultimate end product taurine help? This is what throws off our SAM/SAH ratio, and why taking methylfolate doesnt seem to help. maybe this is why TUDCA helps maybe this is why the guy cured himself eating nothing but scallops (very high in taurine) and rice. maybe this is why ketogenic diets help (meats are sources of methionine)
Bile acids and Vitamin A homeostasis
http://www.rug.nl/research/portal/files/3677919/08_diss.pdf Im focusing on the symptoms and everything needed to eliminate the metabolites.
so far:
Manganese
Glycine
TAURINE
Magnesium
b6 (P5P)
betaine trimethylglycineget a bulk powder form of Taurine from amazon. take 1.5-2 grams to start in divided does.
http://www.nap.edu/read/1349/chapter/8#79 Retinol circulates in the blood as a 1: 1:1 trimolecular complex with retinol-binding protein (RBP) and transthyretin (TTR) (Goodman, 1984a). RBP is released from the liver in combination with retinol, and the holo-RBP complex combines with TTR in the blood. Subsequently, retinol is slowly metabolized in the liver to numerous products, some of which are conjugated with glucuronic acid or taurine, and eliminated in the bile (Sporn et al., 1984). Of the total retinol metabolized, approximately 70% of the metabolic products appear in the feces and 30% are excreted in the urine. Almost all these excreted products are biologically inactive metabolites. For a more detailed review of retinol metabolism, see Goodman and Blaner (1984).
Night blindness:
Taurine supports the integrity of photoreceptors necessary for night vision2, 3, in a process known as rhodopsin regeneration. Rhodopsin is the primary pigment in photoreceptor rods and so vision in low-light conditions is supported. It also helps to protect cell membranes from free radical damage and helps to remove toxins and debris.4Taurine is found in the photoreceptors at levels ten times greater than other amino acids.5
TEWL andproteinmis-folding
http://www.in-cosmetics.com/RXUK/RXUK_InCosmetics/2015-Website/Documents/in-cos15, IS, T3,D3, Unlock the power of nature, Piera M. Pericu.pdf?v=635664145578959704 Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.
my Chinese herbalist once explained that anger, anxiety and depression are cause my your liver not working as it should.
in my case roaccutane damaged my liver.
I lost my relationship and my best friend due to depression and anger. I'd say the liver is the cause, I would look into it if I were youI was exactly the same as you, I would cry for no reason. Get angry at little petty things. I was going crazy. I wasn't..... ME!
vit D and magnesium helped but I reckon the Chinese medicineare what improvedmy mental state.
I say go find a good Chinese herbalistholy shit, i just read something about "Angry Liver" I really think im on to something. It ties into a lot ofsymptomsespeciallywith bile flow, TEWL, GNMT, braincells, night blindness, dopamine etc. I cant believe i didnt see this before. its actually pretty simple when you think about it.
accutane upregulates GNMT throwing off our methyl groups. A highly upregulated GNMT depletes methionoine, which in turn depletes TAURINE indirectly by not having the substrate for our bodies to manufature it. Taurine is also needed for fattyacidsynthesis. Taurine keeps the bile liquid preventing Cholestasis.
Glyine and Taurine are the two bile salt conjugates. Accutane gets detoxified by two different ways, 1. through glucurondination, 2. throughtaurine conjugation?!
http://cot.food.gov.uk/sites/default/files/cot/cotstavita.pdf 19. Vitamin A and derivative compounds can be conjugated in the liver with glucuronic acid or taurine (EVM, 2003; IOM, 2001). as always, follow the money:
http://www.google.com/patents/US4545977 Osmolytes seem to be a big thread in this... they basically introduce water back into the cells that accutane literally dries out.
I keep coming back to the thing we know is true. When your skin dries out from a drug, dry air, or UV radiation... it tries to protect itself with fatty acids and taurine!
http://www.ncbi.nlm.nih.gov/pubmed/1941178 Now it explains here, that accutane (CRA) can be used for methionine toxicity. so wouldnt the opposite be true? wouldnt taking methionine or its ultimate end product taurine help? This is what throws off our SAM/SAH ratio, and why taking methylfolate doesnt seem to help. maybe this is why TUDCA helps maybe this is why the guy cured himself eating nothing but scallops (very high in taurine) and rice. maybe this is why ketogenic diets help (meats are sources of methionine)
Bile acids and Vitamin A homeostasis
http://www.rug.nl/research/portal/files/3677919/08_diss.pdf Im focusing on the symptoms and everything needed to eliminate the metabolites.
so far:
Manganese
Glycine
TAURINE
Magnesium
b6 (P5P)
betaine trimethylglycineget a bulk powder form of Taurine from amazon. take 1.5-2 grams to start in divided does.
http://www.nap.edu/read/1349/chapter/8#79 Retinol circulates in the blood as a 1: 1:1 trimolecular complex with retinol-binding protein (RBP) and transthyretin (TTR) (Goodman, 1984a). RBP is released from the liver in combination with retinol, and the holo-RBP complex combines with TTR in the blood. Subsequently, retinol is slowly metabolized in the liver to numerous products, some of which are conjugated with glucuronic acid or taurine, and eliminated in the bile (Sporn et al., 1984). Of the total retinol metabolized, approximately 70% of the metabolic products appear in the feces and 30% are excreted in the urine. Almost all these excreted products are biologically inactive metabolites. For a more detailed review of retinol metabolism, see Goodman and Blaner (1984).
Night blindness:
Taurine supports the integrity of photoreceptors necessary for night vision2, 3, in a process known as rhodopsin regeneration. Rhodopsin is the primary pigment in photoreceptor rods and so vision in low-light conditions is supported. It also helps to protect cell membranes from free radical damage and helps to remove toxins and debris.4Taurine is found in the photoreceptors at levels ten times greater than other amino acids.5
TEWL andproteinmis-folding
http://www.in-cosmetics.com/RXUK/RXUK_InCosmetics/2015-Website/Documents/in-cos15, IS, T3,D3, Unlock the power of nature, Piera M. Pericu.pdf?v=635664145578959704 Excellent finds TTH2014! Particularly about taurine playing such an important part in night vision. I'd not read this before (or may have just overlooked it), but it gives me more weight to a lot of your recent theory. I'm going to get hold of some to supplement.
Interestingly one of the most effective things I've found for tane sides is actually pumpkin seeds (for mental clarity especially), and these are a good source of a few of the minerals youmention - magnesium, zinc andmanganese. I've tried supplementing all these things individually, but with less results than I get from eating only 50g of seeds per day. I actuallystopped eating these for some time as they are supposed to be a 5AR inhibitor, but reading into this in more detail it appears they do reduce DHT, but via a different mechanism to 5ARinhibition.
Have recently come off TUDCA after taking600mg daily for 5-6 weeks (along with active B6, B12, folic acid, D3, selenium) as I was starting to feel a bit sh1t on it, and was getting pains in my liver (under right rib) just like I did when I'd come off tane. Having stopped it I feel fine again -probably a bit better than before even with better mental clarity. I'm not sure if I wasbecoming depleted in something on that regime,butwill restart in a few weeks and add taurine and glycine!
do you supp on riboflavin (b2) aswell? That helps absorbs the other b vitamins
Ok I just got Glycine powder gonna team it with taurine powder and consuming organic lamb liver.
Not sure about the TUDCA I got tho, it is in a capsule form. The other ingredients in it were rice flour and magnesium stearate
does anybody know if it would make a difference, powder or capsule???
Can't believe this thread is still alive.
2 years and 4 months post Accutane, I am still having hairloss problem. My acne is worse than ever.
Been to a new derm recently and he said accutane side effects can't last that long.
I hate my life so much
Same. Cant believe im still wobbling around honestly lol. I wobble around work like a 95 year old guy my joints are so brittle. They dont even "hurt" anymore, they are just very tired. I was walking up the stair scaffoling today and my balance is terrible. Almost fell over.
When someone calls me for something i wonder if they really just said my name and then when i realize they did i usually reply "what"
My eyes are so annoying that i am approved to wear shaded safety glasses. Thank god.
Everyone that knows me knows im the accutane guy. I do my best to spread the truth and they all know its a brain chemo drug and leave me alone. Other than that, can i go home yet?
Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.
I get and am also sick of living this way.Despite all of the efforts in the thread nothing adds up to a can of beans with any of it being correct. All we know at this point is that going to the doctor, or messing with things moremight not be the answer, and instead eating true, caveman style meals and food might restore our health over a long period of time. I have seen inprovements, but its not hard for it to be expected with the kind of raw shit i eat LOL. Ive also found a lot of power with fasting. I dont want to be spiritual with you now but if you try it message me. I am about to start another 3 day fast, which is enough for me, about twice a month. Dont fall into the supplimentation talk,of adding more, if anything in a way us accutaners simply need less. Do you have more symptoms to share? Stomach pains or malfunctions?
yeah I've seen many of the symptoms like dry eyes dry skin, and yes my stomach does feel irritable. He'll even water gives me heartburn. Milk totally screws with me aswell. One glass and the mucous buildup is terrible, also bloody nose usually during winter time. I thank those that responded as well and am having a hard time quoting you guys since I'm on myphone. Anymore help and a direction to go would be awesome. I also have tryedjuice fasting but haven't had the willpower to stay the course more than two days. I'm definitely going to try hard and give that a shot in a week. I might even try a water fast for a couple of days maybe. There seems to be some intelligent folks in this thread and interested to here what more you guys throw at me. If I want to heal anything I believe accutanee worsened it's definitely my depressive mentality.
PM me? Might as well make accutane friends. I was joking earlier in this thread we could all go live in the woods together and just take turns hunting. Its really not funny but idk what else to do cuz like allllll you guys ive tried everything and still have that accutane depression. Sucks.
Signed,
Introvert now
Looks like my acne is back when I try high dose of vitamin A. I wonder is anybody have the same side effect?
yes same here. I see an increase in my acne which for me is good.
what form are you taking and what dosage?
I took Swanson capsules once 20000 IU and second time 10000 IU.
Looks like my acne is back when I try high dose of vitamin A. I wonder is anybody have the same side effect?
yes same here. I see an increase in my acne which for me is good.
what form are you taking and what dosage?
I took Swanson capsules once 20000 IU and second time 10000 IU.
The amount of acne is still low but on my "t-spot" between my eyes and my temples I now and then see some pimple with sebum.
I think you use these then?
http://www.swansonvitamins.com/swanson-premium-vitamin-a-10000-iu-500-sgels
Fish Oil + Palmitate ( Retinyl Palmitate )
Please keep us updated with your symptoms.
My only speculation is that the liverproduces hormones again with the Vitamin A.
Looks like my acne is back when I try high dose of vitamin A. I wonder is anybody have the same side effect?
yes same here. I see an increase in my acne which for me is good.
what form are you taking and what dosage?
I took Swanson capsules once 20000 IU and second time 10000 IU.
The amount of acne is still low but on my "t-spot" between my eyes and my temples I now and then see some pimple with sebum.
I think you use these then?
http://www.swansonvitamins.com/swanson-premium-vitamin-a-10000-iu-500-sgels Fish Oil + Palmitate ( Retinyl Palmitate )
Please keep us updated with your symptoms.My only speculation is that the liverproduces hormones again with the Vitamin A.
working theory on this....
accutane upregulates GNMT---> hyper active GNMTeliminatesmethionine resulting in disturbed methyl status--->leading to taurine depletion(taurine is needed to conjugate excess synthetic retinoids) ---> taurine depletion leadsto faulty bile acid synthesis ---> leading to cholestasis---> resulting in excess accutane metabolite being stored in liver (thats why it takes months for accutane to work)--->leading to no real vitamin A being used for hormone production (body thinks it doesnt need anymore vitamin A because of aperceivedexcess) ---->resulting in avicious cycle.
I think the body shuts down thefatsolubleabsorptionpathways to protect itself eventually leading to all of the other side effects including IBS. IBS could be the result of long term inflammation, cellpermeability,cytokine release (taurinecan help with this as well) accutane acts as a solvent to pop the cell membranes resulting in water loss.osmolytes protect this from happening.
introducing preformed vitamin A is akin to trying to jumpstart a car imo. youre going to see sparks for the wrong reason. doesnt solve the battery(liver) problem
If we can reverse the cholestasis, and the body can start to accept normal vitamin A.... maybe there is a first in first out mechanism in the liver or fat that can get rid of the stored metabolite. now could we experience side effects from this? probably
retinotaurine=inactive retinoic acid metabolite ready for excretion
low taurine = high liver retinol. and 15-40% in plasma retinol levels.
also......
http://www.nricm.edu.tw/jcm/20/201_2-p1_19.pdf
Accumulation of vitamin A is the net consequence of uptake, biotransformation and elimination processes within an individual. Once vitamin A is absorbed, taurine exert synergistic actions in scavenging it may be transformed into vitamin-thionein. Although the half-life of vitaminthionein in the liver and kidney is not known exactly, it is many years with continued retention, there is progressive accumulation in these tissues. The accumulated amount of vitamin A in the tissue was effectively reduced by taurine. Taurine is a special amino acid, which possesses an amino group and a sulfonate group. These functional groups might bind with vitamin A, and then stimulated the excretion of such compounds. I
Additionally, it seems that TUDCA is able to reduce stress to any cell'sEndoplasmic Reticulum; an organelle in cells that serves as a highway from the nucleus out into the cytoplasm, and aids in folding proteins. Through reducing ER stress, TUDCA has been implicated in a wide range of beneficial metabolic effects such as reducing insulin resistance and diabetes, and being a neurological protection agent.
However, usages of TUDCA beyond the liver are preliminary whereas usage of TUDCA for helping an already harmed liver is quite reliable as TUDCA is used in clinical settings (hospitals) for treating cholestasis.
so you think adding Vitamin A just adds up to the already high levels. We should first expell the excess out with Taurine and TUDCA?
i think thats one part and honestly I think we are lacking real Vitamin A so a daily dose should give our livers what it needs and in the mean time the Taurine and TUDCA Activates the bile again so the old Vitamin A gets excpelled.
So what happens when bile isnt flowing corrrectly? Could it cause IBS? Because my ibs pretty much is gone now and I think it due to TUDCA.
Taurine alone can relieve ER stress.
Without knowing how much taurine to take (2 grams? 6 grams? 15 grams?) or how long it takes to get rid of the stored metabolite... i dont know about taking vitamin A at all. i would just eat normal foods that have beta carotene. Im excited about it saying taurine relieving hypercalcemia.. maybe this could take care of long term joint pains, reverse calcified tendons.
The scary part comes when/if it starts working, do we experience side effects all over again as its being excreted? or side effects x10?!
On 11/15/2015 at 1:09 PM, Mike San said:Thanks heaps as usual....so must we have TUDCA as well (hard to source here in Aus) or would it make sense to try solo taurine (easy to source)?
TUDCA and other Nootropics I would recommend PowderCity. They got the best Shipping by far, very fast and no problems with customs twice.
They do 3rd party testing and in-house testing and within the Reddit Community it is one of the best known nootropic providers
The powder below comes with a measuring scoop and 40$ for 25 gram is one of the best deals on the internet.
You only have to "cap"them yourself, so you have to buy empty capsules.
[Edited link out]
On 11/15/2015 at 11:41 AM, tryingtohelp2014 said:
Without knowing how much taurine to take (2 grams? 6 grams? 15 grams?) or how long it takes to get rid of the stored metabolite... i dont know about taking vitamin A at all. i would just eat normal foods that have beta carotene. Im excited about it saying taurine relieving hypercalcemia.. maybe this could take care of long term joint pains, reverse calcified tendons.
The scary part comes when/if it starts working, do we experience side effects all over again as its being excreted? or side effects x10?!
Well, I would go for a high dose like 4.5 grams and adjust on the results.
On 11/15/2015 at 4:42 PM, Walden Rev said:On 11/15/2015 at 1:09 PM, Mike San said:Thanks heaps as usual....so must we have TUDCA as well (hard to source here in Aus) or would it make sense to try solo taurine (easy to source)?
TUDCA and other Nootropics I would recommend PowderCity. They got the best Shipping by far, very fast and no problems with customs twice.
They do 3rd party testing and in-house testing and within the Reddit Community it is one of the best known nootropic providersThe powder below comes with a measuring scoop and 40$ for 25 gram is one of the best deals on the internet.
You only have to "cap"them yourself, so you have to buy empty capsules.[Edited link out]
On 11/15/2015 at 11:41 AM, tryingtohelp2014 said:
Without knowing how much taurine to take (2 grams? 6 grams? 15 grams?) or how long it takes to get rid of the stored metabolite... i dont know about taking vitamin A at all. i would just eat normal foods that have beta carotene. Im excited about it saying taurine relieving hypercalcemia.. maybe this could take care of long term joint pains, reverse calcified tendons.
The scary part comes when/if it starts working, do we experience side effects all over again as its being excreted? or side effects x10?!
Well, I would go for a high dose like 4.5 grams and adjust on the results.
all of these studies suggest 50mg/per KG and 6 weeks to see effects. so if youre 200lbs... yeah 4-5 grams in divided doses.would seem like a good start! you would have to take too much TUDCA to get that much taurine no?
p5p(active B6) helps taurine get absorbed. B6 is also needed to convert cysteine to taurine as well. also synergistic with magnesium. a lot of bodybuilders stack taurine and magnesium for muscle cramps associated with steroid use.
so stacking : B6/Taurine/Magnesium glycinate
Supplimenting activities will NOT REVERSE YOUR LONG TERM ACCUTANE DAMAGE!!!!!!!! Taurine, ginsing, or magnesium. This will NOT REVERSE ACCUTANE!
Sorry to start yelling but lets please keep the thread in check.
Id STILL like to hear more about what you guys eat, how life is, where youre working.
Supplimenting activities will NOT REVERSE YOUR LONG TERM ACCUTANE DAMAGE!!!!!!!! Taurine, ginsing, or magnesium. This will NOT REVERSE ACCUTANE!
Sorry to start yelling but lets please keep the thread in check.
Id STILL like to hear more about what you guys eat, how life is, where youre working.
Hoffman larochetrolls REALLY stepping up today! Hey Alan, whats the name of this thread? you want to know where people are working??? what a fucking weirdo!!!!!!!!!!!
Supplements are worthless.
They really are. And when youstop and think its really such a joke were still trying fuckin suppliments. Even if we are fucked suppliments are damn dumb lol.
Alan, you first have to learn how to spell "supplements"....before you can say they dont work. Too dumb to even be a troll.