http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546435/
"Because inflammation precedes and promotes the progression of liver fibrosis, the use of antiinflammatory drugs has been proposed. Corticosteroids are only indicated for the treatment of hepatic fibrosis in patients with autoimmune hepatitis and acute alcoholic hepatitis (S1). Inhibition of the accumulation of activated HSCs by modulating either their activation and/or proliferation or promoting their apoptosis is another strategy. Antioxidants such as vitamin E, silymarin, phosphatidylcholine, and S-adenosyl-l-methionine inhibit HSC activation, protect hepatocytes from undergoing apoptosis, and attenuate experimental liver fibrosis..."

Interesting Vitamin E came up, does anyone here supplementit? It my also mean anyone having liver trouble may have luck with Vitamin E, because as well as reducing inflammation it also reduces Vitamin A activity
Once again, I don't pretend to know too much about the body, I am just interested, and in this case supplementing 1000 IU of Vitamin E would be relatively tame. An effect of megadosing would be reduced activity of Vitamin K (interesting as it lowers Vitamin A activity as well), but I don't recommend that

Mmmm old silvana creamery rawmilk

I understand your reasoning, yet I do believe our body has reached a "good" homeostasis with Accutane Vitamin A. Our bodies managed to survive with that.
So with that said, there is nothing to detox, our body thinks it doesnt need to detox.

We need to kickstart the Vitamin A cycle just like we did when we started the Accutane course; We replaced the true Vitamin A with accutane.
Everyday we were using accutane we said to our bodies "use this Vitamin A" everyday for 4-5-6 months.
And yes I do believe epigenetics changed like some of you said, but if we changed it then, we change it again!

I want to replicate this cycle yet with the trueVitamin A. Like the doctors did in some studies.
I want every cell to start using the true Vitamin A again, so I'm starting a "Accutane" course with good Vitamin A.
This will cause alot of stress to the body because its replacing the accutane with the true Vitamin A and thats why our detox paths need to be in perfect shape hence the Taurine and the TUDCA.

Dont know who you are adressing this to but I didnt mention anything about genes.

I'm interested in your supplements.

- What Vitamin A are you taking and what is the dosing?

- You talked about topical use of Vitamin A, do you buy it in a lotion form?

I'll make sure my stack differs from yours so we can test the effectiveness.

Taking natural vitamin a from animal liver im assuming youd do will not reaccutane you. Cis retin acid shrinks many glands inside the body. While this sounds fun

Sorry, the gene thing was a while back, and it wasn't you, in fact could have been 50 pages ago...
Retinyl palmitate is the type of Vitamin AI am taking, in 5000 IU capsules (tedious having about 20 of them, problem is I am moving soon so I can't order online, and can't find more in bulk), and I will probably have my 250th capsule tomorrow, and I had my first one about 2 weeks ago

1.25m IU in total, 1.5mg per capsule for the first hundred, 2.25mg for the second 150 (don't know how that works, both said 5000 IU)
= 485mg=~32mg/day, while my accutane dose was 80mg/day, if you want to make the comparison

For the topical application, I break a capsule and mix it into olive oil, and apply the olive oil. I might have used 10 capsules that way, so maybe 30mg/day orally, 2mg/day topically. I have been applying some to my shoulder too, and the joint pain there has lessened, but that could be due to gym work orplacebo, and likely doesn't do anything, but I plan to keep doing it.

I have been using olive oilregularlythroughoutthe year regularly to moisturize the skin after taking more showers, because I was playing more sport, so I guess my results in that regard are controlled, its just that I can't say for sure if I am getting results

Yea, the Cystic Fibrosis post was a couple pages ago proposed by a few takers of the 23andme gene test. I like everyone's thesis in all of this. I'm game to try out any reasonable treatment. Only thing is I kind of want to postpone starting any VItamin A regime because I am awaiting some emails back from a few colleges that are doing Accutane side effect studies. There's one at Duke university in North Carolina and another in Univ. of Zurich Switzerland who are actually specifically focused on my retinoid side effect of Intracranial pressure. I can't wait to get our site going and have all of us complete full detailed individual reports as this is finally really starting to open up. I think it's only a matter of time we get to the bottom of all this. I applaud everyone's tenacity through this endeavor and a true testament to human nature and science. Albeit done on a random acne forum bombarded by pure ignorance and indifference at times from biased individuals.

Identifying the Genetic Predictors of Severe Acne Vulgaris and the Outcome of Oral Isotretinoin Treatment
Sponsor: Duke University

Inclusion Criteria: Completed at least one course of oral isotretinoin treatment; OR started treatment but discontinued prior to completion due to adverse side effects

https://www.clinicaltrials.gov/ct2/show/NCT01727440?term=isotretinoin&rank=15

Antiacne Medications Pseudotumor Cerebri (AAMPTC)

https://www.clinicaltrials.gov/ct2/show/NCT02149615?term=isotretinoin&rank=86

Yeah, if you are having Intracranial pressure I would be careful, as that is a possibly fatal effect of vitamin A toxicity.
For me I am pretty sure if a doctor looked at me they would give me a clean bill of health, just never healed as quickly, gained fitness slower, injured easier...
Overuse injuries have been the story of my life since I was 16...

Here is an interesting article showing the effects of topical vitamin A vs oral vitamin A
"In conclusion, our results provide evidence that human topical exposure to retinol- or retinyl ester-containing cosmetic creams at 30,000 IU/day and maximal use concentrations do not affect plasma levels of retinol, retinyl esters or RAs, whereas single oral doses at 10,000 IU or 30,000 IU produce significant increases in plasma retinyl esters and RAs."
http://www.ncbi.nlm.nih.gov/pubmed/16243460
What it could mean is topical vitamin A does pretty much nothing  

Keep praying And remember GOD is with you and he have the power to do everything.

Pray for you and all of US ! He will hear !

Wow, another connection to misfolding proteins. Good find Modeea.

[Edited link out]

Fortunately, as the Cornell researchers point out, UPR is a complex signaling program mediated by three ER transmembrane receptors, one of which requires the osmolyteinositolto function properly. It is good to know that there are other osmolytes which can be of benefit to help prevent the dilemma of misfolded proteins. Among these arebetaine, creatine, glycine, taurine, trehalose,andbeta-alanine,each of which is naturally found in living tissue in substantial quantities, is readily available, has been used safely in relatively large amounts as supplements or as components of foods for long periods of time, and is reasonably inexpensive.

this list of supplements almost mirrors that oldpatent used for eliminating accutane

I came off accutane in June 2014 and it's almost 2016. My face, hair and scalp are still soooo dry and my ibs is still terrible. Can anyone tell me if the oil can come back? It might sound stupid but I miss my glow and my thick hair   

I am so hopeful that I will be back to what I was one day!

so is this basically saying that when Glycine gets replaced by alanine or valine due to a deficiency, thatproteins then get misfolded? now could this be due to accutane upregulating GNMT? did the retinoic acid dislodge or throw this out of balance with it being one of the three AR receptors? will massive doses of Glycine correct anything?

http://www.life-enhancement.com/magazine/article/3024-life-extension-methuselahs

An important class of natural chemical chaperones that help stabilize the proper folding conformation of proteins are the osmolytes. These include betaine, inositol, taurine, glycerophosphocholine, choline, and creatine.5The principal organic osmolytes in the mammalian brain include amino acids (such as proline, alanine, and glycine), choline, creatine, inositol, and taurine.5The osmolytes are maintained at particularly high concentrations in the kidneys, which are exposed to high osmolality (high concentrations of salt and urea), but cells in other tissues can also be exposed to hyperosmolality, although to a lesser extent than in the kidneys. Plants, bacteria, and yeasts also rely on the same and some other (e.g., trehalose) osmolytes for protein stability. We [Durk Pearson & Sandy Shaw] have been taking a cocktail of osmolytesincludingproline, betaine, inositol, taurine, creatine,andglycinefor several months to help maintain our proteins in a properly folded state. We recently addedbeta-alanineto the mix. [And more recentlytrehalose.] Although one probably wont, in the short term, notice anything as a result of improved protein folding, if one wants to reach the longer term in good condition, maintaining proper protein structure is vital.

I havent read anywhere in all the pages here that someone would mention to eat raw bacteria packed food. Other than me. And me and the guy praying are told to quiet. Good luck. The answers are right here, god gave you everything you need.

Threads closed

Alan, give it a rest. probiotics were mentioned numerous times... kombuchca for the glucuronic acid. sauerkraut and kefir also talked about on this thread by MANY.L plantarum and its manganese mn-sod protector mentioned by me specifically..

if eating healthy solved everything, i wouldve been healed 20 years ago... if eating healthy did anything for you, you wouldnt even be here.

again, arent you the guy who tried to scam everyone on here saying you had the cure for $5? LOL, beat itjoker

There is no point sacrificing your long term health for it though.
You seem set on doing it though, so maybe get your blood and urine checked, so if you have the misfortune of coming back to this forum post-treatment we have a clear before-after. Not everyone suffers though, it may be worth for you.

Have you ever dieted hard enough that you got to very low bf%, such as <7%? On your way there your libido completely dies, so you could have Miss Universe on your lap, grabbing your cock with one hand, holding a hamburger with the other,and your complete attention would be on the hamburger.

The difference between being like that and being on Accutane is that you start eating again, your boners come back, and if you work out and are at 7% bf, you have plenty of girls wanting to get boned. After Accutane, you are probably still unconfident, you have been having mood swings for the last 9 months, you may suffer ED temporarily if you are a bit unlucky like me, or permanently if you are more unlucky like other users, you aren't lean, and you look like a vampire because you have been avoiding the sun the whole time. No acne isn't going to solve all your problems

http://www.ncbi.nlm.nih.gov/pubmed/132142

Try some topical Vitamin A, it is better than the other stuff which dries your skin out. I would even recommend olive oil or something like that for your skin after showers, because I think acne prone skin is aggravated when people wash it too frequently with hot water, dries out the skin, so you produce more oil... feedback loop etc.

Whatever you want to do though mate, have a crack. Personally I would supplement VitaminsA&D orally in small doses,as well as Zinc,start cutting and working out (bar workouts, push-ups, core, single leg squats... If you have access to a gym make use of it!) to lower body fat, and see where that takes you. I have no idea if you are currently lean, but most people in general aren't, but if you are already 6-pack lean the diet part would be irrelevant

IMO the three things that contribute to acne or nutritional deficiencies, hormone profile, and genetics.
You can't change genetics but try improving the first two before you risk your health

EDIT: I just read your profile, and your acne seems more severe than mine ever was. I would still recommend the same advise (cutting, vitamins and zinc), but if your acne is making you depressed the risk may certainly be worth it.
It is just for most of here, we weren't aware of the potential long-term side-effects, and wouldn't have gone on it if we had known. If it is well and truly your last resort, and you aware of the risks and want to take it, nobody here is going to stop you
If thehypothesis that I am currently testing is correct, many of the symptoms may be due to hypovitaminosis A, so perhaps supplementing minimal vitamin A may reduce the chance of side effects occuring. Best of Luck!
http://escholarship.org/uc/item/88t998r8
http://www.ncbi.nlm.nih.gov/pubmed/25117163

Probiotics are not live bacteria, more synthetic stuff. I will not give my passion of proper nutrition a "rest," especially when its related to Accutane like this. Do you know what you are summarizing about when you say "healthy eating?" No? And I am here because as much as i've improved i still have symptoms. I am also here to tell you that supplementing with kombucha or whatever acid isn't going to do jack for ya. Cold hard facts I know they hurt because youre hoping they might work but they wont, prayer and live food will give you a much better chance. This posting isn't for you but for everyone who may come across it.

Nutrient rich food is the cure to EVERYTHING!

Eat well for thanksgiving 🙂

Interesting to note that we had a few days of quiet intellectual discussion and then suddenly the 3 accounts: Jahbless, AlantookAccutane, Lucas89 all come back (at the same time) to throw this specific thread off topic yet again. I would ask that no one engage their posts or respond to them until we can get our own forum going.

yeh, why are we being mean to each other anyways.

Yeah please dont engage in our posts, we are such terrible people and you are just the bees knees. Dont blame us for the shitty random thread lol. If you dont want to buy my books (when did i EVER say it was the cure???? it was just master health) then, DONT! Just because you see a shiny toy doesnt mean you have to buy it. Does that make sense?

Be nice little buddy.

Happy thanksgiving all.

S-adenosylmethionine (SamE) has been a fairly safe and effective mood enhancement, but i did not have any luck personally with it or others in repairing accutane damage.

Is there a way to rid the long term depression this drug causes? I took the drug very young. I have all the symptoms that are common. Joint pain, stomach problems and dry skin, dry eyes. I can deal with those side effects I just want relieve from my mind. I'm currently 25 and have been on Effexor, fluoxetine and sertraline for a month. If anything I feel worse. I'm constantly crying everyday out of nowhere and I'm sick and tired of living this way. I pretty much signed up to post this and I'm hoping there's a way to at least scratch the surface of all this. Any response is greatly appreciated.

my Chinese herbalist once explained that anger, anxiety and depression are cause my your liver not working as it should.

in my case roaccutane damaged my liver.
I lost my relationship and my best friend due to depression and anger. I'd say the liver is the cause, I would look into it if I were you

I was exactly the same as you, I would cry for no reason. Get angry at little petty things. I was going crazy. I wasn't..... ME!

vit D and magnesium helped but I reckon the Chinese medicineare what improvedmy mental state.
I say go find a good Chinese herbalist

holy shit, i just read something about "Angry Liver" I really think im on to something. It ties into a lot ofsymptomsespeciallywith bile flow, TEWL, GNMT, braincells, night blindness, dopamine etc. I cant believe i didnt see this before. its actually pretty simple when you think about it.

accutane upregulates GNMT throwing off our methyl groups. A highly upregulated GNMT depletes methionoine, which in turn depletes TAURINE indirectly by not having the substrate for our bodies to manufature it. Taurine is also needed for fattyacidsynthesis. Taurine keeps the bile liquid preventing Cholestasis.

Glyine and Taurine are the two bile salt conjugates. Accutane gets detoxified by two different ways, 1. through glucurondination, 2. throughtaurine conjugation?! http://cot.food.gov.uk/sites/default/files/cot/cotstavita.pdf 19. Vitamin A and derivative compounds can be conjugated in the liver with glucuronic acid or taurine (EVM, 2003; IOM, 2001). as always, follow the money:

http://www.google.com/patents/US4545977

Osmolytes seem to be a big thread in this... they basically introduce water back into the cells that accutane literally dries out.
I keep coming back to the thing we know is true. When your skin dries out from a drug, dry air, or UV radiation... it tries to protect itself with fatty acids and taurine!

http://www.ncbi.nlm.nih.gov/pubmed/1941178

Now it explains here, that accutane (CRA) can be used for methionine toxicity. so wouldnt the opposite be true? wouldnt taking methionine or its ultimate end product taurine help? This is what throws off our SAM/SAH ratio, and why taking methylfolate doesnt seem to help. maybe this is why TUDCA helps maybe this is why the guy cured himself eating nothing but scallops (very high in taurine) and rice. maybe this is why ketogenic diets help (meats are sources of methionine)

Bile acids and Vitamin A homeostasis http://www.rug.nl/research/portal/files/3677919/08_diss.pdf

Im focusing on the symptoms and everything needed to eliminate the metabolites.

so far:

Manganese
Glycine
TAURINE
Magnesium
b6 (P5P)
betaine trimethylglycine

get a bulk powder form of Taurine from amazon. take 1.5-2 grams to start in divided does.

http://www.nap.edu/read/1349/chapter/8#79

Retinol circulates in the blood as a 1: 1:1 trimolecular complex with retinol-binding protein (RBP) and transthyretin (TTR) (Goodman, 1984a). RBP is released from the liver in combination with retinol, and the holo-RBP complex combines with TTR in the blood. Subsequently, retinol is slowly metabolized in the liver to numerous products, some of which are conjugated with glucuronic acid or taurine, and eliminated in the bile (Sporn et al., 1984). Of the total retinol metabolized, approximately 70% of the metabolic products appear in the feces and 30% are excreted in the urine. Almost all these excreted products are biologically inactive metabolites. For a more detailed review of retinol metabolism, see Goodman and Blaner (1984).

Night blindness:

Taurine supports the integrity of photoreceptors necessary for night vision^{2, 3}, in a process known as rhodopsin regeneration. Rhodopsin is the primary pigment in photoreceptor rods and so vision in low-light conditions is supported. It also helps to protect cell membranes from free radical damage and helps to remove toxins and debris.⁴Taurine is found in the photoreceptors at levels ten times greater than other amino acids.⁵

TEWL andproteinmis-folding

http://www.in-cosmetics.com/RXUK/RXUK_InCosmetics/2015-Website/Documents/in-cos15, IS, T3,D3, Unlock the power of nature, Piera M. Pericu.pdf?v=635664145578959704

hey, I just bought TUDCA and taurine....
i took taurine for two days, normal then added TUDCA and bam! Felt like crap. Do you recall this happening? Could it be my body is going through detox?

I get and am also sick of living this way.Despite all of the efforts in the thread nothing adds up to a can of beans with any of it being correct. All we know at this point is that going to the doctor, or messing with things moremight not be the answer, and instead eating true, caveman style meals and food might restore our health over a long period of time. I have seen inprovements, but its not hard for it to be expected with the kind of raw shit i eat LOL. Ive also found a lot of power with fasting. I dont want to be spiritual with you now but if you try it message me. I am about to start another 3 day fast, which is enough for me, about twice a month. Dont fall into the supplimentation talk,of adding more, if anything in a way us accutaners simply need less. Do you have more symptoms to share? Stomach pains or malfunctions?

Ignore Alan. I think he is a paid Troll from Hoffman Laroche. anytime we get closer... the trolls show up to derail the thread.