http://www.google.com/patents/EP2289500A1?cl=en

 

• Physiologically, RBP-retinol must complex with TTR in order to achieve a high steady-state concentration of RBP-retinol. This interaction creates a large molecular size complex which resists glomerular filtration and permits delivery of retinol to extra-hepatic target tissues. Inhibition of RBP-TTR interaction results in a reduction of circulating RBP as the relatively small sized RBP-ligand complex would be lost through glomerular filtration. The reduction in circulating RBP then causes a reduction in circulating retinol. This effect has been established in vivofor HPR by several investigators. This effect has also been observed in vivo using all-trans and 13-cis retinoic acids (See, e.g., Berni R, Clerici M, Malpeli G, Cleris L, Formelli F; Retinoids: in vitro interaction with retinol-binding protein and influence on plasma retinol, FASEB J. (1993) 7:1179-84).
• [0268]
  The mechanism of action underlying this effect can be explained by the disruption of RBP-TTR interactions. In order to explore this possibility and to further validate the RBP-TTR screen, the effects of all-trans retinoic and 13-cis retinoic acid, using the conditions the conditions specified for analysis of HPR, were examined. The data obtained (see FIG. 6) are entirely consistent with the in vivo data. This finding further validates the ability of this assay to detect known physiological inhibitors of RBP-TTR interaction.

  <--- Modeea we have to reverse this.

  want to know why your joints hurt, or have calcium deposits after accutane? here you go....  they also mention protien misfolding.

  Abnormal levels of vitamin A, and/or its associated transport proteins (retinol binding protein (RBP) and transthyretin (TTR)) are also correlated with the manifestation of other diseases, including metabolic disorders. An example is seen in diabetes, where abnormal levels of retinol were seen in both type I and type II diabetic patients, but not normal patients. Other diseases include pseudotumor cerebri (PTC), idiopathic intracranial hypertension (IIH), and bone-related disorders, including cervical spondylosis, spinal hyperostosis, and diffuse idiopathic skeletal hyperostosis (DISH). In addition, vitamin A and/or its associated transport proteins, TTR in particular, may play a role in protein misfolding and aggregation diseases, including Alzheimer's disease and systemic amyloidosis.
  [0006]
  Disorders associated with retinoid-related physiological manifestations continue to be a problem throughout the world. Therefore, there is a need to provide for methods and compositions to treat these diseases.

  seems they tried to patent something that will help us....

   

  CLAIMS(11)

  1. A compound of Formula (II) for use for the manufacture of a medicament for modulating serum retinol binding protein (RBP) or transthyretin (TTR) levels or activity in a mammal with hyperostosis, or Alzheimer's disease, or Idiopathic Intracranial Hypertension or Bone-Related Disorders or Protein Misfolding and Aggregation Diseases or Alstr¶m-Hallgren Syndrome, wherein the compound of Formula (II) has the structure:

     

  Inventors	Jay Lichter, Kenneth Widder
  Applicant	ReVision Therapeutics, Inc.

  https://en.wikipedia.org/wiki/Fenretinide    uh oh..... just like accutane.... now read what it does and how its possibly stored!

   Fenretinide accumulates preferentially in fatty tissue such as the breast, which may contribute to the effectiveness of fenretinide against breast cancer.^[4][5] Phase III clinical trial data has suggested that fenretinide reduces breast cancer relapse in pre-menopausal women.^[6] Common side effects associated with fenretinide treatment include skin dryness and night-blindness,
   

On 10/29/2015 at 12:25 PM, BillionProblems said:

On 10/29/2015 at 6:49 AM, tryingtohelp2014 said:

On 10/28/2015 at 1:17 PM, BillionProblems said:

On 10/28/2015 at 12:28 PM, tryingtohelp2014 said:

On 10/28/2015 at 6:54 AM, BillionProblems said:

Hey guys,
i am so happy that i found this Forum! 3 years ago i took Roaccutan (isotetrinoin), but Not Long and low dose. I had big side-Effects and stopped taking Roaccutan
My main Problem is the Hyperhidrose (extreme sweating) [Edited image out]
i was at 10 Different doctors und tried Many Many Medications:
somodren
vagantin
opipramol
sage tea
a lot Minerals and Vitamines
and at Last Zyprexa (olanzapin), which helped me to stop sweating for 1-2 months, bug slowly the Hyperhidrose comes back!!

I come from Germany and my english isnt realy good, please Be Patient
i Would prefer to read every page in this Thread but my english is to Bad

Does anybody had the Same Problem (Hyperhidrose) After taking Roaccutan and can help me??? Any Medications/drugs??
does anybody Know what is going on with my Body??

please help me [Edited image out][Edited image out]
i cant and won't live with this Problem [Edited image out]

Hope anybody reply

you have whats called TEWL. basically it confirms your skin is damaged from accutane, and cant hold onto the water. you literally feel dried out. evening primrose oil (GLA)is the only thing that i come up with.

Thank you so much for your reply
okay TEWL i have Never heard beforeSounds intresting, is there a Different betweenTEWL and a "normal" Hyperhidrose
yes i feel dried out i Must Drink every 30 Minuten, sometimes more and have headache
Funnily enough i have two cans of CLAcapsules(Linolsaure), but i havent tried them. Is that the Same what you use?
it's sold here for weight less
can you give me informations about dosage and effect?

not CLA... GLA. if you google search TEWL and accutane... some GLA studies come up.

On 10/28/2015 at 9:10 PM, marlin15 said:

On 10/28/2015 at 12:28 PM, tryingtohelp2014 said:

On 10/28/2015 at 6:54 AM, BillionProblems said:

Hey guys,
i am so happy that i found this Forum! 3 years ago i took Roaccutan (isotetrinoin), but Not Long and low dose. I had big side-Effects and stopped taking Roaccutan
My main Problem is the Hyperhidrose (extreme sweating) [Edited image out]
i was at 10 Different doctors und tried Many Many Medications:
somodren
vagantin
opipramol
sage tea
a lot Minerals and Vitamines
and at Last Zyprexa (olanzapin), which helped me to stop sweating for 1-2 months, bug slowly the Hyperhidrose comes back!!

I come from Germany and my english isnt realy good, please Be Patient
i Would prefer to read every page in this Thread but my english is to Bad

Does anybody had the Same Problem (Hyperhidrose) After taking Roaccutan and can help me??? Any Medications/drugs??
does anybody Know what is going on with my Body??

please help me [Edited image out][Edited image out]
i cant and won't live with this Problem [Edited image out]

Hope anybody reply

you have whats called TEWL. basically it confirms your skin is damaged from accutane, and cant hold onto the water. you literally feel dried out. evening primrose oil (GLA)is the only thing that i come up with.

tryingtohelp, you sound veryknowledgeable. any idea why the entire skin of my body is thinning. This is gradual, and it started right after accutane usage. Its the weirdest thing. I know they say when you're on accutane, your skin is more thin and fragile, but mine never recovered, and is getting worse.

I believe its a collagen problem imo. Accutane causes a glycine deficiency by hyper activating the GNMT enzyme. Glycine is the major amino acid in collagen.

im currently taking

8000mg of Glycine powder mixed with some Glutamine

600 mg of magnesium glycinate (more glycine... docotors best brand) with some P5P

10 mg Manganese

okay and how much does it helps you? How much does it minimize the extrem sweating in percent?
Comes the positive effect of GLA immediately of After some days/week
i have often a red Head, i think it is a psychic Problem, tiggered from the hyperhidrose. Does GLA helps against the red Head too?
my Body feels overheated with hot flashes
do you have the Same Problems ?

I bought this glycin powder, is that correct?
http://www.amazon.de/Glycin-reines-n-essentielle-proteinogene-Aminosaure/dp/B0106B78CK
Do you take glycine once a day or 4000mg evening- 4000mg Morning
Think you so much, i hope this will help me

I have question to all - how you deal with unhealthy thoughts? I mean, because of several antibiotics courser my digestion is sh*t, I feel bloated and tired almost always, but I am not helping myself to recover. I mean I think about it all the time, thinking that because of some stupid decision in the past I'm gonna feel unwell for my whole life, even if I am noclairvoyant and I can't predict the future. I mean I feel that way 4 years, no doctor, no medication, no supplement made any difference to me, sometimes I think that my obssesion about that is not helping my gut to heal. I just want to return to past and feel like I used to do, but it's clearly impossible. I'm telling to myself that if I finally get better then I'll the most happy person in the world, but most often my brain is telling me that I will never restore my health. I'm trying to change this thought pattern, but it's like impossible. People are cured from really bad diseases like cancer, and I can't deal with freaking indigestion, maybe I am just weak person?

EDIT I mean if I just get sick I would accept that. Maybe with time, but I will accept that. What I can't accept that is my own fault

I have question to all - how you deal with unhealthy thoughts? I mean, because of several antibiotics courser my digestion is sh*t, I feel bloated and tired almost always, but I am not helping myself to recover. I mean I think about it all the time, thinking that because of some stupid decision in the past I'm gonna feel unwell for my whole life, even if I am noclairvoyant and I can't predict the future. I mean I feel that way 4 years, no doctor, no medication, no supplement made any difference to me, sometimes I think that my obssesion about that is not helping my gut to heal. I just want to return to past and feel like I used to do, but it's clearly impossible. I'm telling to myself that if I finally get better then I'll the most happy person in the world, but most often my brain is telling me that I will never restore my health. I'm trying to change this thought pattern, but it's like impossible. People are cured from really bad diseases like cancer, and I can't deal with freaking indigestion, maybe I am just weak person?

EDIT I mean if I just get sick I would accept that. Maybe with time, but I will accept that. What I can't accept that is my own fault

I can ignore headache, brain fog, whatever. You can't ignore your stomach hurting all day. I feel you. If I didn't have stomach issues id probably never even know my brain fog was related to Accutane. Read meditations by Marcus Aurelius. It's the personal diary of one of the best generals in history. Changed my life and set me on this path. Things happen tofor a reason. Use it as ammo. I will change the world and fix many problems. I'll probably be president later on in my life.I always wanted to. You think it's crazy talk but it's what's keeping me up working.These side effects got me charged up to keep going. Reframe your situation. Constantly. Reframe reframe reframe. See the chance to perform better. And then perform better.

On 11/1/2015 at 4:35 PM, Modeaa said:

tryingtohelp, i don't know, maybe because RBP and TTR are suppose to bind to retinol and accutane is 13-cis-retinoic than the RBP-TTR complex cannot be formed(cause there is no retinol for it to bind and maybe the retinoic signale the body not to take more retinol? but maybe retinol can help?).

 

https://en.wikipedia.org/wiki/ Unfolded_protein_response

''Functions

The initial phases of UPR activation have two key roles:

Translation Attenuation and Cell Cycle Arrest by the PERK Receptor This occurs within minutes to hours of UPR activation to prevent further translational loading of the ER. ''

i was thinking about that er stress might occur to the cells becuase of the increase cells replication, so the cell speed up it's pace and die faster but ultimtely erors occurs(, so the cells cannot continue this high speed life cycles to continue, conncected also to foxo.

http://www.sciencedirect.com/science/article/pii/S0925443913002901
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

https://en.wikipedia.org/wiki/Neprilysin

Neprilysin is a

zinc

-dependent

metalloprotease

...It also degrades the

amyloid beta

peptide whose abnormal

misfolding

and aggregation in

neural tissue

has been implicated as a cause of

Alzheimer's disease

. as a

membrane-bound protein

, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the

Golgi apparatus

to the cell surface.

Ann N Y Acad Sci.2004 Jun;1021:436-40.

Author information

Abstract

Author information

Abstract

Hey guys, first post here, though I have been reading for the last three and a half years.
My dose was 2 months at 80mg per day (2x40mg).
When I was on it I dealt with what most of you probably did, including dry skin, rashes, multiple nose bleeds per day, mood swings a bit, sensitivity to sunlight, the normal jazz. As a guy, didn't have to be worried about pregnancy, and thought it would be short term pain for long term gain.
 It was going to be 9 months but I stopped because of joint pain because I felt it was affecting my performance going into the start of the Athletics season (which I thought was a bit weak because I had been told that once I got it over and done the only lasting effect be a clear face, everything else would subside after a few weeks and I might be sacrificing a clear faced future ...)
The first worrying sign that I had was ED. Usually I would have a wet dream once week or fortnight(naturally was nofap back then), maybe 3 times a month. About three weeks after stopping I noticed I hadn't gotten hard in about 2 weeks, whereas usually I was quite the horny teenager. Then I noticed I couldn't get hard at all.
And believe me I tried
That was when I first looked up and heard the long term sides, and while I had mood swings on the drug, that was the first time I thought about suicide, as all my dreams were going up in smoke, from having a professional sporting career to, at the time, maybe even having a family
Currently my sides are fairly livable, no more ED, got much of my athleticism back, tendinosis has subsided and gaining strength again. The main one was learning new things. I always felt I would pick things up with ease, whereas it became very difficult and made the competitive learning environment something that I didn't enjoy participating in, and killed my competitive spirit in such pursuits 
I was also state athlete when I was 16 and I took the drug, and had a promising future in my sport, however I never got any quicker or stronger, developed patellar tendinitis, which lasted for over a year, and ended up tearing as ACL on my "good" knee. As it killed my enthusiasm in learning, it killed my competitive nature in sport, as the more I trained the more I injured myself... In my last year of high school I was glad I could manage to represent the school until I did my knee, whereas I would have liked to play state and have a crack at the national draft...

Anyways
The way I understand it, is that when you are loading isotretinoin, as it is fat soluble, it forces your body to process much of the isotretinoin and Vitamin A reserves. Thus, early in your treatment you are suffering from minor Vit A toxicity and then there is plenty of isotretinoin as well, and by the time you get later in your treatment you are suffering from isotretinoin toxicity, which is very similar, but not the same as Vitamin A toxicity. This is why some get night blindness, and other signs and of Vit a deficiency while getting signs of Vit a toxicity as well.
IMO many of the sides are caused because the lack of Vit A, and currently I am loading it at 1/3 of the dose that is chronic if consumed daily for 6-18 months, which is (4000iu/3=~1300iu)/kg, as well as taking 3000iu of Vit D, because an imbalance I believe is responsible for many of the very negative sides associated with both accutane and vit a toxicity. In the near future I will look into Vitamin K, and maybe Vitamin E (Seems like A interacts heavily with E and D, while D interacts heavily with K) 
When I first started I did notice some of the sides I had while on Tane, but they have since subsided which may or may not have anything to do with the Vit D I'm taking with it now. What I am noticing at the moment is I am laughing more (can't tell jokes because I laugh at my own, could be good or bad.), skin clearing up again (again, too soon to tell if good or bad), more muscularity and strength (I believe/hope this is might be the 5ar receptors kicking back in, but not entirely sure), and increased vertical leap for the first time since I was 16(I could nearly dunk when I was 16, I could nearly dunk at the start of this year. I could easily dunk for the first time on Sunday, though I have been squatting etc in the gym, so it may be more than just the supplements), and very dry hair(A symptom of Accutane, not Vit A toxicity). EDIT: Also taking Fish Oil and Zinc. In the near future might get some cod liver oil so I don't have to take so many pills

I used to have anxiety public speaker, got worse after Tane but it was something I worked on, would have been fine saying my speech at a friends wedding or funeral, it felt like, and now I can't tell jokes without laughing, and while I still haven't cried at all since I was 18, I feel like I would choke up if something terrible were to happen

I'm 6'5, 20 years old, currently I'm 225lb, and feeling the fittest I've felt in my life, and the healthiest I've felt since I was 16. I plan to update, as I have only been taking those vitamins for 2 weeks, way too soon to confirm anything

Anyway, I've been typing this on my phone, so sorry if there are typos, and I'm happy to answer any questions about what I did/have been doing, and once again say what has worked for me may not work for you, and because I plan to continue posting updates, and continue my current treatment, feel free to let me be your guinea pig, and also remember because I only went on for 2 months, maybe what works for me might not work for you.
good luck y'all  

Hey guys, first post here, though I have been reading for the last three and a half years.
My dose was 2 months at 80mg per day (2x40mg).
When I was on it I dealt with what most of you probably did, including dry skin, rashes, multiple nose bleeds per day, mood swings a bit, sensitivity to sunlight, the normal jazz. As a guy, didn't have to be worried about pregnancy, and thought it would be short term pain for long term gain.
 It was going to be 9 months but I stopped because of joint pain because I felt it was affecting my performance going into the start of the Athletics season (which I thought was a bit weak because I had been told that once I got it over and done the only lasting effect be a clear face, everything else would subside after a few weeks and I might be sacrificing a clear faced future ...)
The first worrying sign that I had was ED. Usually I would have a wet dream once week or fortnight(naturally was nofap back then), maybe 3 times a month. About three weeks after stopping I noticed I hadn't gotten hard in about 2 weeks, whereas usually I was quite the horny teenager. Then I noticed I couldn't get hard at all.
And believe me I tried
That was when I first looked up and heard the long term sides, and while I had mood swings on the drug, that was the first time I thought about suicide, as all my dreams were going up in smoke, from having a professional sporting career to, at the time, maybe even having a family
Currently my sides are fairly livable, no more ED, got much of my athleticism back, tendinosis has subsided and gaining strength again. The main one was learning new things. I always felt I would pick things up with ease, whereas it became very difficult and made the competitive learning environment something that I didn't enjoy participating in, and killed my competitive spirit in such pursuits 
I was also state athlete when I was 16 and I took the drug, and had a promising future in my sport, however I never got any quicker or stronger, developed patellar tendinitis, which lasted for over a year, and ended up tearing as ACL on my "good" knee. As it killed my enthusiasm in learning, it killed my competitive nature in sport, as the more I trained the more I injured myself... In my last year of high school I was glad I could manage to represent the school until I did my knee, whereas I would have liked to play state and have a crack at the national draft...

Anyways
The way I understand it, is that when you are loading isotretinoin, as it is fat soluble, it forces your body to process much of the isotretinoin and Vitamin A reserves. Thus, early in your treatment you are suffering from minor Vit A toxicity and then there is plenty of isotretinoin as well, and by the time you get later in your treatment you are suffering from isotretinoin toxicity, which is very similar, but not the same as Vitamin A toxicity. This is why some get night blindness, and other signs and of Vit a deficiency while getting signs of Vit a toxicity as well.
IMO many of the sides are caused because the lack of Vit A, and currently I am loading it at 1/3 of the dose that is chronic if consumed daily for 6-18 months, which is (4000iu/3=~1300iu)/kg, as well as taking 3000iu of Vit D, because an imbalance I believe is responsible for many of the very negative sides associated with both accutane and vit a toxicity. In the near future I will look into Vitamin K, and maybe Vitamin E (Seems like A interacts heavily with E and D, while D interacts heavily with K) 
When I first started I did notice some of the sides I had while on Tane, but they have since subsided which may or may not have anything to do with the Vit D I'm taking with it now. What I am noticing at the moment is I am laughing more (can't tell jokes because I laugh at my own, could be good or bad.), skin clearing up again (again, too soon to tell if good or bad), more muscularity and strength (I believe/hope this is might be the 5ar receptors kicking back in, but not entirely sure), and increased vertical leap for the first time since I was 16(I could nearly dunk when I was 16, I could nearly dunk at the start of this year. I could easily dunk for the first time on Sunday, though I have been squatting etc in the gym, so it may be more than just the supplements), and very dry hair(A symptom of Accutane, not Vit A toxicity). EDIT: Also taking Fish Oil and Zinc. In the near future might get some cod liver oil so I don't have to take so many pills

I used to have anxiety public speaker, got worse after Tane but it was something I worked on, would have been fine saying my speech at a friends wedding or funeral, it felt like, and now I can't tell jokes without laughing, and while I still haven't cried at all since I was 18, I feel like I would choke up if something terrible were to happen

I'm 6'5, 20 years old, currently I'm 225lb, and feeling the fittest I've felt in my life, and the healthiest I've felt since I was 16. I plan to update, as I have only been taking those vitamins for 2 weeks, way too soon to confirm anything

Anyway, I've been typing this on my phone, so sorry if there are typos, and I'm happy to answer any questions about what I did/have been doing, and once again say what has worked for me may not work for you, and because I plan to continue posting updates, and continue my current treatment, feel free to let me be your guinea pig, and also remember because I only went on for 2 months, maybe what works for me might not work for you.
good luck y'all  

hey I tried something similar a while ago by overdosing on vit D, along with its co-factors like, magnesium and vit k2.

I noticed heaps of energy felt really good, dry sore red eye disappeared. After a few weeks tho I came crashing down again and all symptoms came back!

i never have thought about vit A tho. Could it be that I was deficient in vit A as well? 

On 11/4/2015 at 8:14 AM, tryingtohelp2014 said:

On 11/4/2015 at 6:54 AM, trantran83333 said:

On 11/3/2015 at 11:23 AM, Fchawk said:

 

hey I tried something similar a while ago by overdosing on vit D, along with its co-factors like, magnesium and vit k2.

I noticed heaps of energy felt really good, dry sore red eye disappeared. After a few weeks tho I came crashing down again and all symptoms came back!

i never have thought about vit A tho. Could it be that I was deficient in vit A as well? 

does not explain a lot of people on here, including me, who when eating anything rich in Vitamin A , feel toxic all over again.  this is 10-15-20 years after stopping accutane.  

On 11/4/2015 at 4:34 PM, Fchawk said:

On 11/4/2015 at 8:14 AM, tryingtohelp2014 said:

On 11/4/2015 at 6:54 AM, trantran83333 said:

On 11/3/2015 at 11:23 AM, Fchawk said:

 

hey I tried something similar a while ago by overdosing on vit D, along with its co-factors like, magnesium and vit k2.

I noticed heaps of energy felt really good, dry sore red eye disappeared. After a few weeks tho I came crashing down again and all symptoms came back!

i never have thought about vit A tho. Could it be that I was deficient in vit A as well? 

does not explain a lot of people on here, including me, who when eating anything rich in Vitamin A , feel toxic all over again.  this is 10-15-20 years after stopping accutane.  

My theory is that when you have Vitamin A, it increases the amount of retinoids circulating in our bodies, and in a body that has adapted to survive with toxic amounts of Isotretinoin in our body, it can™t, at least initially, handle it.

 

As Vitamin D can reduce the effects of Vitamin A toxicity, my theory is that when you went on vitamin D it also reduced the effects of Isotretinoin toxicity, and thus you felt great. However, eventually you ran out of Vitamin A (maybe because of a low Vitamin A diet?), and then you may have ran into effects of Vitamin D toxicity and Isotretinoin became the dominant retinoid in your body, making you feel awful. This is all speculation, I am going to continue my self-experimentation and update how I feel in the coming weeks and months, and all I have to go with right now is I CURRENTLY feel very good, even if my skin and hair is dry

 

Just wondering tryingtohelp2014, what were your vitamin A foods?

 

If it was preformed (aka liver/supplements), or beta-carotene? If it was Beta-Carotene, and your body still reacted adversely, perhaps (as I might be interpreting the facts to fit my theory), your body recognises it has a Vitamin A deficiency, and thus turns said B-C into Vitamin A, which it wouldn™t do If you had ample Vitamin A, because it is impossible to get Vitamin A toxicity from consuming Beta-Carotene. However, as I said earlier your body has changed to survive with Accutane toxicity, and thus it struggles, at least initially, with even normal levels of Vitamin A.

Also the main sources of Beta-carotene are:
- Carrots
- Pumpkin
- Spinach
- Sweet Potato
If you had a bad reaction to these foods, it means you have an adverse reaction to levels of Vitamin A that are still VERY FAR off toxic, as your body wouldn't bother processing it if you had ample Vitamin A

Most preformed Vitamin A is in meat, particularly their liver.

This one below shows the interaction between Vitamins A and E

http://www.ncbi.nlm.nih.gov/pubmed/2359300

 

This study below shows a significant decrease in mortality when malnourished children in poorer countries are given two 200,000 IU pills of vitamin A per year, 6 months apart. They were between 12 and 71 months years old, so very young, but the supplement scheme was benificial. However, they would have been getting ample amounts of Vitamin D as well. I feel the reason for many problems in first world countries is intake for both A and D is low, but a deficiency in one causes toxicity in another, leading to very low RDIs for both

 

http://jameslindlibrary.org/wp-data/uploads/2014/07/Sommer_A_1986.pdf
 

This one below shows the interaction between Vitamins A and D, as well as K. It would also explain why most vitamin A toxicities occur with supplements, because Cod Liver Oil also has plenty of Vitamin D

 

[Edited link out]

On wikipedia, which I feel wouldn't have a bias towards megadosing, 4000 IU/kg daily would cause chronic toxicity after 6-18 months. For me that would be 400,000 IU per day for several months. Little kids are having 200,000 IU, and are better for it.

(BTW, just because I found a few studies, doesn't mean I feel I know I'm right. I am sure I could have the opposite conclusion and still probably find studies that back up)

Thus, if post-Tane sufferers get sides after having even small doses of Vitamin A, it might not be indicating for you to stop, personally I™m praying it™s a sign my body is restoring some equilibrium to my system, and it won™t happen overnight, just as Accutane poisoning didn™t happen overnight. That is unless our bodies are so screwed up that our bodies can't process vitamins as well as babies and toddlers, which I do not think is the case

 

Currently I™m feeling very good, improving performance in the gym and on the track for the first time in years, so I™ll keep it updated for the coming weeks and months. Feel free to let me run out my experiment, and see I go before you take the plunge  
 

I also forgot to mention in my first post I am supplementing Fish Oil and Zinc, and have been for some time now. Maybe the helped me throughout this year, but if so very marginally, as I have seen more improvement in the past few weeks then the year previous

 

On 11/4/2015 at 5:40 PM, Walden Rev said:

On 11/4/2015 at 4:34 PM, Fchawk said:

On 11/4/2015 at 8:14 AM, tryingtohelp2014 said:

On 11/4/2015 at 6:54 AM, trantran83333 said:

On 11/3/2015 at 11:23 AM, Fchawk said:

 

hey I tried something similar a while ago by overdosing on vit D, along with its co-factors like, magnesium and vit k2.

I noticed heaps of energy felt really good, dry sore red eye disappeared. After a few weeks tho I came crashing down again and all symptoms came back!

i never have thought about vit A tho. Could it be that I was deficient in vit A as well? 

does not explain a lot of people on here, including me, who when eating anything rich in Vitamin A , feel toxic all over again.  this is 10-15-20 years after stopping accutane.  

My theory is that when you have Vitamin A, it increases the amount of retinoids circulating in our bodies, and in a body that has adapted to survive with toxic amounts of Isotretinoin in our body, it can™t, at least initially, handle it.

 

As Vitamin D can reduce the effects of Vitamin A toxicity, my theory is that when you went on vitamin D it also reduced the effects of Isotretinoin toxicity, and thus you felt great. However, eventually you ran out of Vitamin A (maybe because of a low Vitamin A diet?), and then you may have ran into effects of Vitamin D toxicity and Isotretinoin became the dominant retinoid in your body, making you feel awful. This is all speculation, I am going to continue my self-experimentation and update how I feel in the coming weeks and months, and all I have to go with right now is I CURRENTLY feel very good, even if my skin and hair is dry

 

Just wondering tryingtohelp2014, what were your vitamin A foods?

 

If it was preformed (aka liver/supplements), or beta-carotene? If it was Beta-Carotene, and your body still reacted adversely, perhaps (as I might be interpreting the facts to fit my theory), your body recognises it has a Vitamin A deficiency, and thus turns said B-C into Vitamin A, which it wouldn™t do If you had ample Vitamin A, because it is impossible to get Vitamin A toxicity from consuming Beta-Carotene. However, as I said earlier your body has changed to survive with Accutane toxicity, and thus it struggles, at least initially, with even normal levels of Vitamin A.

Also the main sources of Beta-carotene are:
- Carrots
- Pumpkin
- Spinach
- Sweet Potato
If you had a bad reaction to these foods, it means you have an adverse reaction to levels of Vitamin A that are still VERY FAR off toxic, as your body wouldn't bother processing it if you had ample Vitamin A

Most preformed Vitamin A is in meat, particularly their liver.

This one below shows the interaction between Vitamins A and E

http://www.ncbi.nlm.nih.gov/pubmed/2359300

 

This study below shows a significant decrease in mortality when malnourished children in poorer countries are given two 200,000 IU pills of vitamin A per year, 6 months apart. They were between 12 and 71 months years old, so very young, but the supplement scheme was benificial. However, they would have been getting ample amounts of Vitamin D as well. I feel the reason for many problems in first world countries is intake for both A and D is low, but a deficiency in one causes toxicity in another, leading to very low RDIs for both

 

http://jameslindlibrary.org/wp-data/uploads/2014/07/Sommer_A_1986.pdf
 

This one below shows the interaction between Vitamins A and D, as well as K. It would also explain why most vitamin A toxicities occur with supplements, because Cod Liver Oil also has plenty of Vitamin D

 

[Edited link out]

On wikipedia, which I feel wouldn't have a bias towards megadosing, 4000 IU/kg daily would cause chronic toxicity after 6-18 months. For me that would be 400,000 IU per day for several months. Little kids are having 200,000 IU, and are better for it.

(BTW, just because I found a few studies, doesn't mean I feel I know I'm right. I am sure I could have the opposite conclusion and still probably find studies that back up)

Thus, if post-Tane sufferers get sides after having even small doses of Vitamin A, it might not be indicating for you to stop, personally I™m praying it™s a sign my body is restoring some equilibrium to my system, and it won™t happen overnight, just as Accutane poisoning didn™t happen overnight. That is unless our bodies are so screwed up that our bodies can't process vitamins as well as babies and toddlers, which I do not think is the case

 

Currently I™m feeling very good, improving performance in the gym and on the track for the first time in years, so I™ll keep it updated for the coming weeks and months. Feel free to let me run out my experiment, and see I go before you take the plunge  
 

I also forgot to mention in my first post I am supplementing Fish Oil and Zinc, and have been for some time now. Maybe the helped me throughout this year, but if so very marginally, as I have seen more improvement in the past few weeks then the year previous

 

Great post. I share the same theory with the addition of Taurine + TUDCA.
The Taurine + TUDCA combo activates the bile again and helps the liver excreting the accutane.
Im currently consuming liver alot and soon I recieve the beta carotene ( +lutein ).
I also switch the liver for COD liver oil sometimes, to make sure I dont overdose on 1 supplement.
wether its the Taurine + TUDCA  or the liver, my vision is razorsharp again. Also alot more energy like you said
Im also starting to jog 10k 3 times a week again. 

Keep us updated
Wald

 

Great post. I share the same theory with the addition of Taurine + TUDCA.
The Taurine + TUDCA combo activates the bile again and helps the liver excreting the accutane.
Im currently consuming liver alot and soon I recieve the beta carotene ( +lutein ).
I also switch the liver for COD liver oil sometimes, to make sure I dont overdose on 1 supplement.
wether its the Taurine + TUDCA  or the liver, my vision is razorsharp again. Also alot more energy like you said
Im also starting to jog 10k 3 times a week again. 

Keep us updated
Wald

On 11/5/2015 at 10:27 AM, yetanotheraccutanevictim said:

Also, our vitamin A metabolism is screwed up, preventing proper vitamin A absorption and assimilation, causing deficiency. There are a lot of studies indicating this. We are indeed deficient in true vitamin A. However, as learned anecdotally, I would avoid megadosing vitamin A containing foods until proper metabolic function is restored by eliminating as much synthetic vitamin A as possible.

On 11/5/2015 at 10:27 AM, yetanotheraccutanevictim said:

Was trying to figure out the entirety of vitamin A absorption, assimilation, and excretion biochemically by looking at study after study and trying to piece things together but I soon came across this video which explained everything:
[Edited link out]

I highly recommend checking it out. It's quite informative.

I believe that purging the gallbladder of bile and excreting it completely multiple times will be our quickest method of eliminating the accutane from our bodies and restoring normal function. As I've shown previously, the body has a hard time eliminating retinoids from the liver AND fully excreting them out the intestine. They are constantly recirculated.

Anything to improve bile flow and elimination will help. Cholestyramine is a great chemical binder (unlike clays & charcoal) that selectively targets and binds bile instead of other molecules that we don't necessarily want to eliminate like nutrients from foodstuffs.

binding agent + gallbladder flushing + laxative = large excretion of retinoids.

Also, our vitamin A metabolism is screwed up, preventing proper vitamin A absorption and assimilation, causing deficiency. There are a lot of studies indicating this. We are indeed deficient in true vitamin A. However, as learned anecdotally, I would avoid megadosing vitamin A containing foods until proper metabolic function is restored by eliminating as much synthetic vitamin A as possible.