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Manganese (with the other recommended vitamins) has increased my hair shedding, skin shedding, increased head pressure, and made me have a bloody nose. Lovely. I may need to take a break from this regimen.
what exactly are you taking? how much, and when?
sounds like youre moving something around.
Moving stuff around is never a good thing, zinc moves stuff around, eating vitamin A moves stuff around they are both detrimental in my experience. The problem is how is it going to move out when the bile acid transporters have been down regulated due to the toxic effect of the drug?
This is as simple as it gets for me.....
*If* we have something to move around.... IF....
There is only ONE known way to conjugate any excess retinoid metabolite out of the body. ONE.
Thats thru phase II glucuorination by way of the glycosyltransferases UGT
There is only ONE nutritional rate limiting cofactor that we can control for this process. manganese. thats it... there is no other way. if anyone can tell me one, post a study.
Now, I'm not talking about pre or pro Vitamin A from foods. We didnt have a problem clearing these things before taking accutane. If we start talking about this, then of course Vitamin D, or any other fat soluable antagonist comes into play. Im just talking about whatever bastardized metabolite that might still be in us.
So how many MG's of manganese should a 220 lb person take?
Yes look up:
Terry Wahl's book called:
Minding My Mitochondria 2nd Edition: How I overcame secondary progressive multiple sclerosis (MS) and got out of my wheelchair.
If she can do that.... why can't we fix ourselves?
Like wtf.
Here is another forum with accutane users figuring out chronic fatigue:
http://forums.phoenixrising.me/index.php?search/17436122/&q=accutane&o=date
Have a Happy New Year everyone.
I'm taking:
Manganese (15mg)
Alpha GPC (choline 600mg 2X/day that's what it says for the daily dosage)
L-glutamine (1000mg 2X/day)
B-complex (each around 100mg or 100mcg depending on B vitamin)
Redmond clay (2175mg)
L-Carnitine (1,270mg) Powder
Undecenoic acid 250mg (candida)
**Vitamin D 5,000mg
*I have not been taking Molybdenum
I do think the increased hair shedding at the very least is due to the vitamin D. I started taking it since my bones were feeling achy as they start to as i get less sunlight in the winter. it makes my gums, teeth ,and bones feel better. I'm sure based upon what was said though it can have effects on A receptors. Correct? What exactly is the mechanism between A and D? Sorry to get anyone's hopes up, but it sounds like it's working for others so far.
Happy New Year!!!
**5,000IU's sorry
Some info I found on liver and tane.
Introduction Isotretinoin is a vitamin A derivative used in the treatment of severe acne and some forms of skin, head and neck cancer. Isotretinoin, like many retinoids, can lead to increase in serum aminotransferase levels, but, unlike acitretin and etretinate, isotretinoin has not been clearly implicated in cases of clinically apparent acute liver injury with jaundice. Background Isotretinoin (eye" soe tret' i noyn), also known as 13-cis-retinoic acid, is an aromatic retinoid similar to vitamin A which is effective in treating recalcitrant nodular acne and other disorders of keratinization. Unlike vitamin A, isotretinoin is not stored in the liver and is not associated with many of the toxic effects of high-dose vitamin A therapy. Its mechanism of action in acne is believed to be mediated by activation of retinoic acid and retinoid X receptors which regulate gene expression important in normalizing cell growth and differentiation. Isotretinoin is considered a second-generation retinoid and its relative lack of receptor specificity accounts for its adverse side effects. All oral retinoids are potent teratogens and must be avoided or used with extreme caution in women of childbearing potential. Isotretinoin was approved for use in acne in the United States in 1982 and it is currently used but only under strict requirements for monitoring and birth control. Isotretinoin is available in generic forms and under several brand names (Absorica, Amnesteem, Claravis, Myorisan, Sotret, Zenatane and previously Accutane) in capsules of 10, 20, 30 and 40 mg; the usual dose in adults being 0.5 to 2.0 mg/kg per day given in two divided doses for 15 to 20 weeks. Higher doses have been used in treatment of head and neck cancers. Side effects are common and include dry skin, nose bleeds, conjunctivitis and hair loss. Use of isotretinoin has also been linked to worsening of hyperlipidemia, hyperostosis, vision and hearing loss, pancreatitis, pseudotumor cerebri, birth defects, depression and suicide. Hepatotoxicity Liver test abnormalities occur in up to 15% of patients on isotretinoin, although marked elevations above three times the upper limit of normal or requiring drug discontinuation are rare (<1%). The liver test abnormalities are typically asymptomatic and transient and can resolve even with continuing therapy. Clinically apparent liver injury due to isotretinoin is exceedingly rare, if it occurs at all. The acute liver injury with signs of hypersensitivity that occurs with etretinate and acitretin has not been described with isotretinoin therapy. Vitamin A-like effects on the liver with accumulation of lipids in nonparenchymal stellate cells has been described in rare patients on isotretinoin therapy, but the role of supplementary use of vitamin A in these cases was not ruled out. Mechanism of Injury The mechanism by which isotretinoin causes serum aminotransferase elevations is not known but it may represent a direct toxic effect, in that it appears to be more frequent with higher dose therapy. Outcome and Management The serum aminotransferase elevations that occur on isotretinoin therapy are usually self-limited and do not require dose modification or discontinuation of therapy. Acute liver injury with jaundice has not been clearly linked to use of isotretinoin. Patients with acitretin or etretinate associated acute liver injury have been found to tolerate isotretinoin without recurrence of liver injury, although isotretinoin is not approved and may not be as effective as acitretin in treating psoriasis. References to isotretinoin hepatotoxicity are given in the Overview section on Retinoids. Drug Class: [Edited link out] [Edited link out]Other Drugs in the Subclass, [Edited link out][Edited link out][Edited link out]
[Edited video out]
Good video to watch for the new year.
I will be retiring from the forums for now. I will post back my results later in the year.
Good luck everyone, let's transform this negative experience into a positive one.
Ever since doing the Manganese protocol my stools become yellow.
The same happens when I use a product like
Foods-Liver-Detoxifier-Regenerator-Capsules [Edited link out]
I'm leaning towards using some Super enzymes with Ox-bile to help and digest because alot of it comes undigested.
On 1/1/2015 at 6:21 PM, Walden Rev said:Ever since doing the Manganese protocol my stools become yellow.
The same happens when I use a product like
Foods-Liver-Detoxifier-Regenerator-Capsules
I'm leaning towards using some Super enzymes with Ox-bile to help and digest because alot of it comes undigested.
Interesting..ive experienced some of this as well. Seems to happen when people start detoxing. Going to make some artichokes today. This helps some people.
we need to pinpoint the cause for this... could be many different causes...pancreatic enzyme,liver,candida, bilirubin clearance, copper detox.
If you experience it from taking that detox brand, i would bet its from the milk thistle.
I think it could be the relationship between choline and manganese. not enough choline? One seems to drain the other when your system starts up again.
I ordered this last week.
https://www.amazon.com/Integrative-Therapeutics-Lipase-Concentrate-HP-90-Veg/dp/B0030N8M5O/
I took accutane 6-7 years ago, and I honestly feel like I'm dying.... at 22. It feels like my heart beats weaker everyday.
That they gave a medication that has been known to cause painful long-term side effects to someone at such a naive and gullible age for facial aesthetic reasons (I had moderate acne) borders on pure evil.
I strongly suspect it has also affected my ability to detox other medications from my system, making the process slower or otherwise stunted.
I've found that deep meditation helps to ease all the symptoms, interrupting the pain signals and keeping the mind focused on getting better.
I just want to also say that the strength and courage in this thread is phenomenal, considering our actual lack of support and possible psychological scarring.
My fatigue problem has not stopped for more than a year. in fact it has worsened since I took antibiotics back in summer and three months ago. Major hair loss problem has been going on for 16 months.
I can't possibly have a colema board in my toilet which I share with other students. I can't afford regular colon hydroptherapy either.
Any other options?
I don't feel depressed by accutane induced problems anymore but since more than 3 years ago, I have been really stressed by other problems in my life. Is chronic stress and anxiety the actual cause of my problems? I don't know. Im willing to try liver flushes and colon cleanse to see if anything improves. I have nothing to lose
Happy New Year everyone!
Consumed a boat load of liquor last night and my skin is looking pretty. Must enjoy this day of skin while it lasts. Kind of torturous really. hehe.
I am feeling optimistic this year! I have that gut feeling 
. Still kind of drunk but defs the optimism will stay.
Stay Healthy everyone.
Happy New Year guys.
Hope you're not feeling too bad.
I'm hopeful that this year I can make massive progress with a recovery.
I still believe that copper overload (have talked about this on my channel on YouTube) is behind the majority of side effects.
Made a video again on Accutane to warn others,
[Edited video out]
I took all my old ones down (well, I made them private) because I came across as too opinionated and a bit dick-ish.
Hopefully I can get this one seen by people, so they can avoid a similar fate to ours.
I will of course let you know once I'm better (if that does turn out to be the case)
I stand by stress and our attitude being important, too.
Samantha, do you take probiotics? I would recommend from my own experience and what you are listing to start there. Gut health has a huge impact on mental health and vice versa. Most of our serotonin is formed in the gut. You want to ensure you have good bacteria to keep your mood positive as a result. Just a thought. But everything else tha thas been listed on here is a good to incorporate too, yoga, healthy diet, reducing stress as much as possible. SLEEP is a major factor in recovery as well. I have hair loss as well. It subsides when i avoid any and all vitamin A products and foods (i get some natural betacarotene from veggies), avoid gluten, and I minimize/cut out sugar. I used the tea tree oil shampoo and conditioner (it's cheap from traders joe's to keep oil down and it has reduced shedding some). Just some thoughts, do with them what you will! Happy New Year 
Why do we think tane had to still be inside us? Can the receptors still be affected without tane still residing. How do you change receptors. It's gotta be them. What's the one thing that has been one of the most puzzling among us? Whether we suffer from too much or not enough vitamin a? I suffer from both. So how do the receptors get screwed and y dont they revert to prelevels?
Who knows? Just thinkin about this is taxing. I'm gunna take a break. I wish yall the best. If you guys come across info on creators or scientists that are alive. Pass the info on to me.
I believe the self searching is nuerotic. It drives me insane. I do feel a sense of family with everyone because we are the only ones who understand eachother-thus sticking around. My point again is if were gunna waste the energy and life, might as well do it trying to get to the source and people smarter than us (at least me). I'm not spouting off as I do on occasion for release. If someone finds a professional source for info please dm me. I will not stop if I have that info. I will put energy into getting a face to face sit down.
Anyone have sleep problems? I think it's more stress-induced. I have bad dreams literally everynight. Every morning I wake up feeling depressed. Sometimes I woke up at the middle of the night crying. Has it happened to any of you before?
Samantha, do you take probiotics? I would recommend from my own experience and what you are listing to start there. Gut health has a huge impact on mental health and vice versa. Most of our serotonin is formed in the gut. You want to ensure you have good bacteria to keep your mood positive as a result. Just a thought. But everything else tha thas been listed on here is a good to incorporate too, yoga, healthy diet, reducing stress as much as possible. SLEEP is a major factor in recovery as well. I have hair loss as well. It subsides when i avoid any and all vitamin A products and foods (i get some natural betacarotene from veggies), avoid gluten, and I minimize/cut out sugar. I used the tea tree oil shampoo and conditioner (it's cheap from traders joe's to keep oil down and it has reduced shedding some). Just some thoughts, do with them what you will! Happy New Year
No not yet. I should take probiotics ASAP. I always have IBS problems and got worse after acctuane (coincidence??) For example, I feel nausious in the morning after brushing my teeth alone. Sometimes I threw up after meal even when I dont feel full at all. I have major sleep problem (nightmaires everyday). I don't think I can have a gluten-free diet but Im not a fan of most gluten-rich food such as bread. I should consult a dietitian tho. How severe was your hairloss and how long it lasted? Happy New Year everyone!
Can anyone recommend a probiotics for me? I've been recommended pure encapsulations 50b and prescript assist but both of them are quite pricey.
Can confirm that taking manganese helps my skin a lot, especially the places I use a lotion on that contains hyaluronic acid.
Just ordered digestive enzymes instead of a probiotic because those historically have caused skin issues as well as abdominal cramping for me.
Also, since taking manganese I have been able to take a multivitamin again without seeing immediate, negative side effects... Will experiment with this some more.
I only take the molybdenum every once in a while, and still hate taking choline/Alpha GPC because it makes me very, very depressed; however, I do eat a lot of eggs etc in its place.
Haven't been taking a B complex or D supp, though I do drink energy drinks that contain B vitamins and I have a separate methyl B12 supp I take every once in a while.
Haven't found something for the irritability yet, though. Could be in large part due to the energy drinks, but seems to always be there waiting to explode at something.
Anyone have sleep problems? I think it's more stress-induced. I have bad dreams literally everynight. Every morning I wake up feeling depressed. Sometimes I woke up at the middle of the night crying. Has it happened to any of you before?
I do have sleep problems. I tend to wake up almost every night around 3-4am. I don't dream or have nightmares though. Wish I was even able to. I think the reason we are all so depressed is because our guts are so screwed up.
No not yet. I should take probiotics ASAP. I always have IBS problems and got worse after acctuane (coincidence??) For example, I feel nausious in the morning after brushing my teeth alone. Sometimes I threw up after meal even when I dont feel full at all. I have major sleep problem (nightmaires everyday). I don't think I can have a gluten-free diet but Im not a fan of most gluten-rich food such as bread. I should consult a dietitian tho. How severe was your hairloss and how long it lasted? Happy New Year everyone!
most dieticians are misinformed. they go by what the big agricultural companies and government tell them. It's the opposite of healthy eating. eat a non allergenic, low toxin, nutrient dense diet mainly from easily digestible foods like a big bone broth with meat. everything grass fed, wild caught, pastured etc.. I hate the word paleo but use that diet as a template. it will get you 90% there.
Can anyone recommend a probiotics for me? I've been recommended pure encapsulations 50b and prescript assist but both of them are quite pricey.
probiotics will definitely help while you are taking them but once you stop, things can go back to how they were. I've used prescript assist with good noticeable results. Look into making your own kefir with grains. It's extremely cheap. You can even make water kefir if you don't do dairy (which would be wise). You need to try to eliminate all grains. It's not just the gluten that is damaging. I can't think of one reason to eat any single grain but I can think of many different mechanisms through which they damage us.
Does anyone else have muscle tremors/tics? For instance occasionally I'll have tremors along my forearms causing my wrists to twitch or I'll get foot spasms/twitches (like restless leg). Idk what is causing it. It started a year after taking accutane. Actually when I got off of the standard american diet is when I started getting these twitches. everything else got a little better but the twitches started up. Quite strange..
about to blow some pathogens out of the water: ordered some peppermint oil, berberine, oregano oil, and some allicin extract along with a great milk thistle supplement.
Do you think we should be taking a continuous dose of the manganese each day or take a large dose every couple of days
Another question.
What about manganese and nightblindness. I have minor trouble reading subtitles with dim light.
It all loops back to Vit A defiencency.
Not sure about the link to manganese but I definitely 99% think that it is the vit A deficiency causing that. I got extreme night blindness from accutane along with multiple eye floaters. my night blindness is better since I've been chowing down on retinol containing foods like liver but I still am plagued with symptoms.
the light sensing cells of the eye are in the eye's retina. these cells are dependent upon vit A to be functional
The role of Vitamin A in the visual cycle is specifically related to the retinal form. Within the eye, 11-cis-retinal is bound to protein "opsin" to form rhodopsin in rods[3] and iodopsin (cones) at conserved lysine residues. As light enters the eye, the 11-cis-retinal is isomerized to the all-"trans" form. The all-"trans" retinal dissociates from the opsin in a series of steps called photo-bleaching. This isomerization induces a nervous signal along the optic nerve to the visual center of the brain. After separating from opsin, the all-"trans"-retinal is recycled and converted back to the 11-"cis"-retinal form by a series of enzymatic reactions. In addition, some of the all-"trans" retinal may be converted to all-"trans" retinol form and then transported with an interphotoreceptor retinol-binding protein (IRBP) to the pigment epithelial cells. Further esterification into all-"trans" retinyl esters allow for storage of all-trans-retinol within the pigment epithelial cells to be reused when needed.[23] The final stage is conversion of 11-cis-retinal will rebind to opsin to reform rhodopsin (visual purple) in the retina. Rhodopsin is needed to see in low light (contrast) as well as for night vision. Kuhne showed that the regeneration of rhodopsin only occurs when retina is attached to retinal pigmented epithelial (RPE).[3] It is for this reason that a deficiency in vitamin A will inhibit the reformation of rhodopsin and lead to one of the first symptoms, night blindness.
Read the 4th paragraph about accutane on this article under 'Vitamin A: Friend or Foe'
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Another story I found in which cleansing the body cured someone. Everyone please read:
I'm about to do a colon cleanse. Deciding between oxypowder (oxygen based) and colonix (fiber based)
Fun fact, I started supplementing with iodine, and nightblindness went away instantaneously. Skin suddenly gets smoother too. My thyroid checks out fine but it definitely starts boosting it's functioning. It's implicaiton with A receptors and A? I have no clue. I take it here and there whenever I have a flare up of symptoms. Which is rare these days now that i've cut out sugar. It's candida that's been giving me acute symptoms.
Fun fact, I started supplementing with iodine, and nightblindness went away instantaneously. Skin suddenly gets smoother too. My thyroid checks out fine but it definitely starts boosting it's functioning. It's implicaiton with A receptors and A? I have no clue. I take it here and there whenever I have a flare up of symptoms. Which is rare these days now that i've cut out sugar. It's candida that's been giving me acute symptoms.
Are you taking the iodine with cofactors like selenium? The logos solution was something that interested me in the past. How much iodine ate you taking? I can expect headaches about every three days. This last month has been tough.