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Repairing the long-term damage from Accutane

 
MemberMember
157
(@tanedout)

Posted : 01/03/2015 9:14 am

I think he is talking about hemp seed oil. Not the RSO.

Hemp seed oil may contain a good percentage of cbd. It also contains omega fats.

 

But the Rso is the real deal I guess, I would like to try that but first I try this for 4 months

Yeah I think he's referring to something like this, basically a health supplement;

http://www.hollandandbarrett.com/shop/product/granovita-organic-hemp-oil-60081414

Interestingly it's quite high in vitamin A.

I've been taking rso (not hemp oil) for about 3 months now, but only in very small amounts - about a rice grain worth per night. It's definitely the best thing I've found for improving sexual sides, but the improvements do seem to have plateaued. Vaping weed probably actually results in more significant improvements for me, but only when stoned.

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MemberMember
157
(@tanedout)

Posted : 01/03/2015 11:48 am

A few interesting things relating to hemp oil - the benefits appear to focus on the perfect balance of essential fatty acids contained in the oil, rather than the presence of CBD etc;

- Hemp oil has been found to repair DNA

http://www.wakingtimes.com/2012/09/06/hemp-can-repair-dna

Why might this be relevant? Because Accutane (isotretinoin) damages DNA...

http://www.ncbi.nlm.nih.gov/pubmed/16232082

- The essential fatty acids in Hemp oil support your immune system;

"The essential fatty acids in hemp seed oil have been shown to promote healthy flora in the intestines and support immune system response and function". Anyone suffering from accutane sides will clearly benefit from a strong immune system, and a number of people have seen improvements from using probiotics.

http://www.globalhealingcenter.com/natural-health/5-health-benefits-of-hemp-seed-oil/

- A very good source of Omega 3 and Omega 6

"Hemp oil is natures most balanced oil for human nutrition (3:1 LA [Omega 6] to LNA [Omega 3] ratio) and is easily digestible"

http://www.regenerativenutrition.com//hemp-oil-flush-efa-cholesterol-omega.asp?

Interesting a number of the things which being deficient in Omega 3 or Omega 6 result in sound like tane sides;

Low Omega 3 (Alpha Linolenic acid) symptoms include impairment of vision and learning ability, behavioural changes, dry skin, immune dysfunction.

Low Omega 6 (Linolenic acid) symptoms include loss of hair, liver degeneration, behavioural disturbance, drying up of glands.

I'm going to try adding 25ml or so of organic hemp oil daily to my current regime as I can see a lot of potential benefits there. A lot of people report improved skin and increased hair growth/reduction in hair shedding (look at reviews on Amazon etc) when taking this, so might be worth a look for anyone suffering from those things.

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MemberMember
76
(@yetanotheraccutanevictim)

Posted : 01/03/2015 12:02 pm

Interesting about hemp oil being high in Vit A. Makes me want it even more now. Which brand do you guys recommend? Also, can we get RSO in Colorado? Where would I go
Did a little research into this stuff just now and decided I'd post some of it here just to give everyone the basics. I'm no expert and I haven't even smoked weed or taken hemp oil in my entire life but yeah... here ya go:
Genus of the marijuana plant:
- Cannabis
3 Different species of Cannabis:
- C. indica - Most widely cultivated in the Western World. Causes the type of high that most people correlate when they think of pot
- C. sativa - Originated in South Asia and it increases your mental clarity and makes you more energetic
- C. ruderalis - Wild populations are seen growing in Central and Eastern Europe. It has a lower THC content than the other two species so it is rarely grown for its recreational use. However, it is high in CBD
cannabis has two main components:
- cannabadiol (CBD) which is about 40% of the plant extract and isn't high in the psychotropic components
- tetrahydrocannabinol (THC) which causes the psychoactive effects associated with being high
*Most of the cannabinoids contain healing properties but THC should be avoided if you don't want the high
If you smoke marijuana, use a vaporizer. Marijuana doesn't cause lung cancer but smoke can still damage the lungs and cause emphysema. Vaping at a low-medium heat (450 Fahrenheit) will increase the amount of CBD you are getting compared to THC. Eating pot is also a good method.
Also, you can purchase hemp oil which is a fantastic source of CBD. It has little to no THC in it so it won't get you high. The oil is either extracted from the plant, stalk, or seeds. HempMeds (a popular hemp oil producing company in CA) extracts the oil from the mature stalks of the hemp plant. The stalk and seeds aren't classified as marijuana according to the U.S. government so hemp oil is legal in all 50 states
Our bodies have an endocannabinoid system which is involved in a variety of physiological processes such as appetite, pain-sensation, mood, and memory. This is a completely natural system. The components in Cannabis can affect this system.
Cannabinoid type 1 receptors (CB1) - Deals with the brain and heart. Also responsible for anti-seizure capabilities
Cannabinoid type 2 receptors (CB2) - Most important. Deals with the gastrointestinal and immune systems. Stimulation of CB2 is what fights cancer because it stimulates the body's weaken immune system and it also lowers inflammation greater than any other natural substance (curcumin as an anti-inflammatory is weak compared to CB2 stimulation) Echinacea can also stimulate these receptors but only mildly
Pure THC laden hemp oil also known as Rick Simpson Oil (RSO) (www.phoenixtears.ca) is loaded with cannabinoids that bind with the cannabinoid receptors in the body.
Contains full spectrum of cannabinoids from the Cannabis plant (At least 85 different active compounds)
It is about 50-60% THC and 10-15% CBD. Also contains concentrated amounts of other useful cannabinoids such as CBN and CBG
Will cause psychoactive effects but the healing properties are potent.
Extracted from C. indica strains when trying to treat physical ailments
Extracted from C. sativa strains when trying to treat mental illnesses
High quality concentrated source of CBD: [Edited link out]
Spray it under tongue and hold for 60-90 seconds
*for added effect, immediately follow it up with a hemp oil shot (Hemp Oil [RSHO]. Squirt a tiny little bit on finger and put under tongue. This is even more potent than Cibdex

I hate how something so natural and beneficial is illegal. Doesn't make any sense... It isn't even physiologically addictive at all.

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MemberMember
157
(@tanedout)

Posted : 01/03/2015 12:20 pm

 

 

High quality concentrated source of CBD: Cibdex

Spray it under tongue and hold for 60-90 seconds
*for added effect, immediately follow it up with a hemp oil shot (Hemp Oil [RSHO]. Squirt a tiny little bit on finger and put under tongue. This is even more potent than Cibdex

I've tried Cibdex and I'm not sure I'd recommend it. I purchased 4 bottles, followed by 10g of RSHO and I can't say I noticed anything from it at all, and bearing in mind that lot sets you back about US$1000 I'm not sure I'd bother. Vaping some recreational weed and I noticed an improvement in sexual sides after less than a week.

Hemp oil (from cold pressed hemp seeds) is a very different proposition to hash oil/RSO made from cannabis buds, although they are often confused. The benefits from RSO appear to be the cannabinoids, CBD, THC etc - however the benefits from the hemp oil appear to be down to the EFA's (essential fatty acids). A number of people have recovered from their tane sides with RSO, but that guy is the first recovery I've seen from consumption of hemp oil alone.

Oh and if you live in Colorado you're one of the lucky ones - you should be able to obtain RSO easily and legally!

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MemberMember
76
(@yetanotheraccutanevictim)

Posted : 01/03/2015 1:07 pm

Oh and if you live in Colorado you're one of the lucky ones - you should be able to obtain RSO easily and legally!

I sure do appreciate your advice! I don't live in CO but I have a buddy there who might be able to get me some.

Right now the RSO isn't my main priority though. I plan on doing intense detoxes like colon cleanses, liver flushes, kidney cleanes, anti-parasitic herbal protocols, and high doses of probiotics taken orally and through enemas.

As for my diet, I am going to be following the Wahl's protocol to the best of my ability. Just got the book yesterday. It's fantastic. The diet is kind of tough.

Here is a quick introduction I typed up (I'm going to try level 3):

 

LEVEL ONE

1) Nine cups of fruits and vegetables every day, broken down as follows:

 

 

  • Three cups tightly packed raw or cooked leafy greens, like kale, collards, chard, Asian greens, and lettuces (the darker the better)
  • Three cups deeply colored vegetables and fruits, such as berries, tomatoes, beets, carrots, and winter squash
  • Three cups sulfur-rich vegetables, including broccoli, cabbage, asparagus, Brussels sprouts, turnips, radishes, onions, and garlic
2) Gluten-Free/Dairy Free
3) Organic, Grass-Fed, Wild-Caught

 

  • High-quality protein from meats
LEVEL TWO
1) Reduce all non-gluten grains, legumes, and potatoes to just two servings per week
It's preferable to eliminate grains and legumes entirely. Eat more nonstarchy vegetables than gluten-free grains and eat more vegetables than fruit.
2) Add seaweed or algae and organ meats to your diet
3) Add fermented foods, soaked seeds and nuts, and more raw foods.

 

  • Raw fruits and vegetables
  • Fermented foods like lacto-fermented sauerkraut, pickles, kimchi, and kombucha tea
  • Soaked and sprouted nuts and seeds
  • Raw animal protein such as suchi, steak tartare, and ceviche
LEVEL THREE
Extremely low-carb, high-fat diet
1) Eliminate all grains, legumes, and potatoes.
That includes non-gluten grains like rice and quinoa.
2) Consume at least 6 cups of vegetables, divided evenly between greens, colored, and sulfur-rich.
You won't be as hungry because of being in ketosis. Try to still eat 6 cups each day.
3) Reduce cooked starchy vegetables and fruit
Limit cooked starchy vegetables to two servings a week. Less is better. Limit fruit to one serving per day, preferably berries or cherries.
4) Add coconut oil and full-fat coconut milk
This will ensure adequate fats for producing ketones
5) Eat just twice per day and fast twelve to sixteen hours every night
If you find it uncomfortable to eat just twice a day, go ahead and keep having three meals when you really need them, but always be sure to wait twelve to sixteen hours between dinner and breakfast.

I've basically been doing everything for the past year minus the seaweed, crazy amounts of vegetables (I really need to get a Vitamix), and ketosis.

Here's a short list of vegetables we should be getting a variety from each and every day:

THREE CUPS OF LEAFY GREENS [vits A, B, C, and K] *indicates high in calcium

 

Arugula*
Beet greens
Bok Choy* and other Asian greens
Chard, all colors
Collard greens*
Dandelion greens*
Kale, all types (curly; lacinato or "dinosaur"; red; etc.)*
Lettuce, all types except iceberg (darker the better)
Mustard greens*
Parsley
Spinach*
THREE CUPS OF COLORED FRUITS & VEGGIES [antioxidants]
Green
Asparagus
Artichokes
Avocados
Beans, green
Cabbage, green
Celery
Cucumbers with skin
Grapes, green
Green peas
Kiwi, green
Limes
Melons, honeydew
Okra
Olives, green
Peppers, green
Snow peas
Sugar snap peas
Zucchini with skin
Red
Beets
Blood oranges
Cabbage, red
Cherries
Cranberries
Grapefruits, red
Grapes, red
Peppers, red
Pomegranates
Radicchio
Raspberries, red
Rhubarb
Strawberries
Tomatoes
Watermelons
Blue/Purple/Black
Aronia berries
Blackberries
Blueberries
Dates
Eggplants
Elderberries
Grapes, black or purple
Figs, purple
Kale, purple
Olives, black
Plums
Prunes
Raisins
Raspberries, black
Yellow/Orange
Apricots
Carrots
Grapefruit, yellow
Kiwi, golden
Lemon
Mangos
Muskmelons
Nectarines
Oranges
Papayas
Peaches
Peppers, orange and yellow
Pineapples
Pumpkins
Squash, summer and winter
Sweet potatoes and yams
Tangerines
THREE CUPS OF SULFUR-RICH VEGETABLES
Cabbage Family (cruciferous, or brassica family) [helps detoxification]
Asparagus
Bok choy
Kale
Cabbage
Collard greens
Broccoli
Cauliflower
Brussels sprouts
Turnips and turnip greens
Rutabaga
Radishes (such as daikon)
Onion Family [anti-microbial & blood vessel health]
Garlic, all types
Onions: red, yellow, and white
Scallions (spring onion)
Chives
Leeks
Shallots
Mushroom Family [balances the immune system]
Mushrooms: all types
If sensitive, reintroduce 6 months later
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MemberMember
157
(@tanedout)

Posted : 01/03/2015 3:00 pm

@yetanotheraccutanevictim, that diet looks good - I wouldn't be surprised if you saw improvements in your condition after a couple of months of that. The hard part will be sticking to it.

I did a few months of intermittent fasting last year (not eating between about 20:00 and about 13:00 the next day) and it's not too hard once you get used to it. I also got a slow-juicer and did a brief juice fast, but really struggled with it.

I don't really buy into 'detoxing' which is more of a marketing term than anything, but there is a lot to be said for eating a healthy diet which will provide your body with all the right nutrients to help it function to an optimum level, as well as avoiding refined sugars, saturated fat and proceeded foods. Again, that takes some willpower to stick to!

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MemberMember
76
(@yetanotheraccutanevictim)

Posted : 01/03/2015 3:33 pm

I don't really buy into 'detoxing' which is more of a marketing term than anything, but there is a lot to be said for eating a healthy diet which will provide your body with all the right nutrients to help it function to an optimum level, as well as avoiding refined sugars, saturated fat and proceeded foods. Again, that takes some willpower to stick to!

I do believe that most "detoxing programs" are indeed scams but I've tried almost everything. Cleansing programs are the one thing I never really gave a chance. I'm going to be doing a month long colon cleanse then an herbal anti-parasitic program all while doing the diet.

As for you avoiding saturated fat, I hope you don't. That's very important for our healing to occur

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MemberMember
5
(@accutanereallysucks)

Posted : 01/03/2015 7:54 pm

Idk there really is not any solution that I have found, a few good ideas people have found to make the days easier, and live the best we can.. but certainly no antedote. sometimes i just think i should start drinking

Not gonna lie, smoking pot doesn't help me, gives me anxiety but i have been drinking the hemp oil (perfect balanced omega) for a few months. good stuff.

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MemberMember
70
(@whackutane)

Posted : 01/04/2015 4:05 am

Has anyone here taken a serious approach to treating adrenal fatigue caused by accutane.

So far my theory is that I had a poor liver from birth, the acne was a result of my liver being unable to filter toxins correctly.

Once i got one accutane, the effects of my liver to inefficiently detox the high amounts of Vitamin A sent my body in overdrive.

This severely taxed my adrenal glands to the point of exhaustion.

For a long time I was unsure of what this was and why this was but its starting to make sense to me now.

If anyone has read my old posts they would have seen that bleeding gums (yeah gross i know !) was a big one for me.
-adrenal glands use of tons of vit C when depleted and this causes scurvy to a lesser degree, bleeding gums being a number 1 symptom.
-my libido hit rock bottom and still sucks, but its getting better, another notable sign of post accutane
-anxiety again ticks both boxes in similar symptoms.

Anyway, just google adrenal fatigue and see if your symptoms match up

This could just be me really but I think I have finally found the answer. Seems like the internet can easssssily complicate things.

Tomorrow I will send off for my 4x saliva test. Results back in about 2 weeks. If I remember I will post them here.
Also about a week into a PMO reboot - Im drawing to a conclusion that because I have found myself in this mess instead of being someone who survived accutane no dramas, there must be a link between poor performing liver and adrenal glands. Excess PMO has direct links with adrenal exhaustion and the stories are easily found.

Food for thought.

If anyone wants to PM me for anymore info about my approach here Im cool to share some useful, links, books and suggestions.

Again this is just me, but Ive been in this situation since jan 2012 and tried a lot of stuff.

Supplements seem to sell well as magic pills, its the massive commitments that see results.

__________________________________________________________________________________________________________________________

Please take a 30 seconds of your life and complete this poll for me :)

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MemberMember
14
(@youbetterloveyourself)

Posted : 01/04/2015 4:51 am

UPDATE: CURE FOUND FOR POST-TANE SYMPTOMS??!?!??!

I think that most of us who have these symptoms and side effects from tane....previously suffered liver defects from birth

My liver is always high in bilirubin since birth. it's called gilbert's

--------

I just improved 50% of my Accutane symptoms from doing a Niacin (vitamin B3) flush.

What happens is you take the Niacin and your body purges any toxins through the skin.

My body turned deep dark RED and I felt like I was on FIRE. Heart was pounding, skin was itching. All is a normal reaction to Niacin.

The effects wear off on there own. But I noticed my chapped lips were gone!!!

My lips returned to normal PRE-TANE!

This might be the solution for us!

[Edited video out]

http://www.amazon.com/Solgar-Niacin-Vitamin-Tablets-Count/dp/B00020IAWI/

http://www.doctoryourself.com/niacin.html

I am not advertising, just want to make some URL links.

 

 

 

On 1/4/2015 at 5:05 PM, koikoi123 said:

Has anyone here taken a serious approach to treating adrenal fatigue caused by accutane.

So far my theory is that I had a poor liver from birth, the acne was a result of my liver being unable to filter toxins correctly.

Once i got one accutane, the effects of my liver to inefficiently detox the high amounts of Vitamin A sent my body in overdrive.

This severely taxed my adrenal glands to the point of exhaustion.

For a long time I was unsure of what this was and why this was but its starting to make sense to me now.

If anyone has read my old posts they would have seen that bleeding gums (yeah gross i know !) was a big one for me.
-adrenal glands use of tons of vit C when depleted and this causes scurvy to a lesser degree, bleeding gums being a number 1 symptom.
-my libido hit rock bottom and still sucks, but its getting better, another notable sign of post accutane
-anxiety again ticks both boxes in similar symptoms.

Anyway, just google adrenal fatigue and see if your symptoms match up

This could just be me really but I think I have finally found the answer. Seems like the internet can easssssily complicate things.

Tomorrow I will send off for my 4x saliva test. Results back in about 2 weeks. If I remember I will post them here.
Also about a week into a PMO reboot - Im drawing to a conclusion that because I have found myself in this mess instead of being someone who survived accutane no dramas, there must be a link between poor performing liver and adrenal glands. Excess PMO has direct links with adrenal exhaustion and the stories are easily found.

Food for thought.

If anyone wants to PM me for anymore info about my approach here Im cool to share some useful, links, books and suggestions.

Again this is just me, but Ive been in this situation since jan 2012 and tried a lot of stuff.

Supplements seem to sell well as magic pills, its the massive commitments that see results.

__________________________________________________________________________________________________________________________

Please take a 30 seconds of your life and complete this poll for me

I was deficient in Vitamin C, Alpha Lipoic Acid, Niacin, Glutithiione, Molybdenum on my micronutrient blood test.

I believe this is from Adrenal Fatigue. I am also taking Adrenal Support from Gaia Herbs. Ashgwanda works great too.

 

 

I just checked my blood type today.

 

 

It's a rare blood: Blood type A Negative. Only 6% of population have it.

Then there is a book on how your blood type effects your personality and the food you should eat!

"Eat Right for 4 Your Type: Complete Blood Type Encyclopedia"

http://www.amazon.com/Blood-Type-Kit-Eldoncard-micropipette/dp/B000FSOCR4

http://www.amazon.com/Eat-Right-Your-Type-Encyclopedia/dp/1573229202

once again not advertising just wanting to share these links.

Quote
MemberMember
143
(@indigorush)

Posted : 01/04/2015 6:43 am

I have Gilbert's syndrome too.

Doubt I did before Accutane, but had no reason to check because my health was always very good.

I don't think you should claim 50% of your side effects have cured from taking 1 niacin pill.

Having dry lips is the least of my problems.

Maybe it'll help in the long-term, but it's just another thing I've already tried in the past.

And here I am, still... despite trying, oh so hard.

I don't want to bring the mood down, but I'm fucking sick of this shit now.

I just want to know if I'm doing the right thing.

I want to know if there is any hope in hell of recovery.

Because, if I knew there wasn't... maybe I could make peace with that.

Quote
MemberMember
157
(@chico-esposito)

Posted : 01/04/2015 9:09 am

My Bilrubin was high but my doctor said don't worry about it. I think i've got Primary Biliary Cirrhosis or at the very least cholestasis.

Primary biliary cirrhosis (PBC) is a slowly progressive disease of the liver ... Bilirubin is often normal at first but rises as the disease progresses.

Quote
MemberMember
76
(@yetanotheraccutanevictim)

Posted : 01/04/2015 9:50 am

Has anyone here taken a serious approach to treating adrenal fatigue caused by accutane.

 

So far my theory is that I had a poor liver from birth, the acne was a result of my liver being unable to filter toxins correctly.

 

Once i got one accutane, the effects of my liver to inefficiently detox the high amounts of Vitamin A sent my body in overdrive.

 

This severely taxed my adrenal glands to the point of exhaustion.

 

If anyone has read my old posts they would have seen that bleeding gums (yeah gross i know !) was a big one for me.

-adrenal glands use of tons of vit C when depleted and this causes scurvy to a lesser degree, bleeding gums being a number 1 symptom.

-my libido hit rock bottom and still sucks, but its getting better, another notable sign of post accutane

-anxiety again ticks both boxes in similar symptoms.

 

Tomorrow I will send off for my 4x saliva test. Results back in about 2 weeks. If I remember I will post them here.

Also about a week into a PMO reboot - Im drawing to a conclusion that because I have found myself in this mess instead of being someone who survived accutane no dramas, there must be a link between poor performing liver and adrenal glands. Excess PMO has direct links with adrenal exhaustion and the stories are easily found.

 

If anyone wants to PM me for anymore info about my approach here Im cool to share some useful, links, books and suggestions.

Interesting theory. I figured with everything that I've been through my adrenals would be shot but I still am able to get erections daily. Do people who have libido problems related to accutane have problems even getting an erection? Is it more about their desire to have sex or what? I still have the desire and the ability. Not sure if someone could be having adrenal insufficiency while still having a libido. Please try to remember to post your cortisol panel results.

I just improved 50% of my Accutane symptoms from doing a Niacin (vitamin B3) flush.

What happens is you take the Niacin and your body purges any toxins through the skin.

My body turned deep dark RED and I felt like I was on FIRE. Heart was pounding, skin was itching. All is a normal reaction to Niacin.

The effects wear off on there own. But I noticed my chapped lips were gone!!!

My lips returned to normal PRE-TANE!

Has anyone here taken a serious approach to treating adrenal fatigue caused by accutane.

 

So far my theory is that I had a poor liver from birth, the acne was a result of my liver being unable to filter toxins correctly.

 

Once i got one accutane, the effects of my liver to inefficiently detox the high amounts of Vitamin A sent my body in overdrive.

 

This severely taxed my adrenal glands to the point of exhaustion.

 

For a long time I was unsure of what this was and why this was but its starting to make sense to me now.

 

If anyone has read my old posts they would have seen that bleeding gums (yeah gross i know !) was a big one for me.

-adrenal glands use of tons of vit C when depleted and this causes scurvy to a lesser degree, bleeding gums being a number 1 symptom.

-my libido hit rock bottom and still sucks, but its getting better, another notable sign of post accutane

-anxiety again ticks both boxes in similar symptoms.

 

Anyway, just google adrenal fatigue and see if your symptoms match up

 

This could just be me really but I think I have finally found the answer. Seems like the internet can easssssily complicate things.

 

 

Tomorrow I will send off for my 4x saliva test. Results back in about 2 weeks. If I remember I will post them here.

Also about a week into a PMO reboot - Im drawing to a conclusion that because I have found myself in this mess instead of being someone who survived accutane no dramas, there must be a link between poor performing liver and adrenal glands. Excess PMO has direct links with adrenal exhaustion and the stories are easily found.

 

Food for thought.

 

If anyone wants to PM me for anymore info about my approach here Im cool to share some useful, links, books and suggestions.

 

Again this is just me, but Ive been in this situation since jan 2012 and tried a lot of stuff.

 

Supplements seem to sell well as magic pills, its the massive commitments that see results.

 

__________________________________________________________________________________________________________________________

 

Please take a 30 seconds of your life and complete this poll for me

 

 

 

 

I was deficient in Vitamin C, Alpha Lipoic Acid, Niacin, Glutithiione, Molybdenum on my micronutrient blood test.

I believe this is from Adrenal Fatigue. I am also taking Adrenal Support from Gaia Herbs. Ashgwanda works great too.

 

 

I just checked my blood type today.

It's a rare blood: Blood type A Negative. Only 6% of population have it.

Then there is a book on how your blood type effects your personality and the food you should eat!

"Eat Right for 4 Your Type: Complete Blood Type Encyclopedia"

http://www.amazon.com/Blood-Type-Kit-Eldoncard-micropipette/dp/B000FSOCR4/ref=sr_1_2?ie=UTF8&qid=1420364915&sr=8-2&keywords=blood+type+test

http://www.amazon.com/Eat-Right-Your-Type-Encyclopedia/dp/1573229202/ref=sr_1_2?ie=UTF8&qid=1420364923&sr=8-2&keywords=eat+for+your+blood+type

once again not advertising just wanting to share these links.

Niacin causes lipolysis which purges a lot of toxins from the body. I may run through Dr. Yu's niacin flush protocol.

Niacin Flush protocol: link

btw, I was also deficient in Vit C (despite heavy supplementation) and alpha lipoic acid.

Look up Alan Christionson's Adrenal Reset Diet book.

quick tip: start eating your carbs after 3pm if you eat carbs. This will help your cortisol slope stay high in the morning and low at night.

sunlight exposure in morning for at least 30min

low blue light exposure at night. I use amber glasses

The diet for your blood type is a scam. There is no scientific proof at all that metabolic typing or a diet for your blood type exists..

Quote
MemberMember
960
(@tryingtohelp2014)

Posted : 01/04/2015 10:30 am

On 1/4/2015 at 10:09 PM, Chico Esposito said:

My Bilrubin was high but my doctor said don't worry about it. I think i've got Primary Biliary Cirrhosis or at the very least cholestasis.

Primary biliary cirrhosis (PBC) is a slowly progressive disease of the liver ... Bilirubin is often normal at first but rises as the disease progresses.

ugh what is wrong here?! Did you have PBC before accutane?

Seems Gilberts is very prevalent on this thread. I too have a high bilirubin count. I didnt have one on any blood test pre accutane. I still believe this is due to a chronic deficiency in Mn. Mn is needed to clear excess bilirubin from the system as well. From the accutane studies i posted, the drug is conjugated more in the intestines for elimination, than in the liver.

2.3.2. Hyperbilirubinemia

250 to 350 mg of bilirubin (see Fig. 2.9), a degradation product of haemoglobin, is formed in
the human body per day. It is highly insoluble in water and therefore bound to albumin in the
circulation (Harb and Thomas, 2007). This unconjugated bilirubin is then transported to the
liver, where it is conjugated with glucuronic acid before excretion into bile. UGT1A1 is the
only significant bilirubin glucuronidating isoform in human (Bosma, et al., 1994; Bosma,
2003). Elevated levels of unconjugated bilirubin in the serum result in jaundice and a
condition known as unconjugated hyperbilirubinemia.
Almost all the GT-A family members have a common
DxD motif, which is involved in coordinating a divalent cation, usually a manganese or
magnesium ion, in the catalytic centre. The metal ion is required for the binding of the
nucleotide sugar (Breton and Imberty, 1999; Wiggins and Munro, 1998). T

For those suggesting Niacin flushes....how does that eliminate the accutane biologically? Niacin itself wouldnt conjugate anything for elimination. Im telling you people as clear as i can, *IF* there is an accutane metabolite residue in our system, there is only one process that binds and eliminates accutane for excretion post p-450 enzyme activity.., and thats glucurodination. glucurodination is regulated by the UDP glucuronosyltransferase process. This process needs one mineral to work properly.

Deficiency, UDP-glucuronosyltransferase: Underactivity of a liver enzyme that is essential to the disposal of bilirubin (the chemical that results from the normal breakdown of hemoglobin from red blood cells).The deficiency of this enzyme (UDP-glucuronosyltransferase) results in a condition called Gilbert's disease in which there are mild elevations of bilirubin pigment in the blood. The elevated bilirubin pigment can sometimes cause mild yellowing (jaundice) of the eyes. People with Gilbert's disease are otherwise entirely normal with no other signs or symptoms and their liver enzymes in blood serum are also entirely normal.

Transcriptional regulation of human UDP-glucuronosyltransferase genes.

Abstract

Glucuronidation is an important metabolic pathway for many small endogenous and exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids, carcinogens and therapeutic drugs. Glucuronidation is primarily catalyzed by the UDP-glucuronosyltransferase (UGT) 1A and two subfamilies, including nine functional UGT1A enzymes (1A1, 1A3-1A10) and 10 functional UGT2 enzymes (2A1, 2A2, 2A3, 2B4, 2B7, 2B10, 2B11, 2B15, 2B17 and 2B28). Most UGTs are expressed in the liver and this expression relates to the major role of hepatic glucuronidation in systemic clearance of toxic lipophilic compounds. Hepatic glucuronidation activity protects the body from chemical insults and governs the therapeutic efficacy of drugs that are inactivated by UGTs. UGT mRNAs have also been detected in over 20 extrahepatic tissues with a unique complement of UGT mRNAs seen in almost every tissue. This extrahepatic glucuronidation activity helps to maintain homeostasis and hence regulates biological activity of endogenous molecules that are primarily inactivated by UGTs. Deciphering the molecular mechanisms underlying tissue-specific UGT expression has been the subject of a large number of studies over the last two decades. These studies have shown that the constitutive and inducible expression of UGTs is primarily regulated by tissue-specific and ligand-activated transcription factors (TFs) via their binding to cis-regulatory elements (CREs) in UGT promoters and enhancers. This review first briefly summarizes published UGT gene transcriptional studies and the experimental models and tools utilized in these studies, and then describes in detail the TFs and their respective CREs that have been identified in the promoters and/or enhancers of individual UGT genes.

This is from another board... somebody else started connecting the dots:
[Edited link out]
"Glucuronidation is the process by with glucuronic acid is bound to the unwanted chemical, making it more soluable so that the chemical may be excreted via the kidneys. So here we see that a lack of Glucuronic acid would inhibit the removal of salicylates from the body, along with the many other chemicals processed through this pathway

though evidence seems to be hard to find this study concludes that glycogen (this is the form in which the body stores glucose) is the substrate from which glucuronic acid is formed from http://www.jbc.org/content/153/1/49.full.pdf

So a lack of glycogen would lower glucuronic acid levels.

And here a study is found that links a manganese deficiency to lower levels of glycogen

http://www.ncbi.nlm.nih.gov/pubmed/7376278

Potentially giving manganese deficiency as a cause of salicylate sensitivity (along with many others)."

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MemberMember
47
(@walden-rev)

Posted : 01/04/2015 11:47 am

Appreciate your continious hunt for more answers Tryingtohelp. Really

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143
(@indigorush)

Posted : 01/04/2015 12:05 pm

http://nutritionalbalancing.org/center/htma/science/articles/copper-toxicity.php

Mentions high bilirubin as high copper can cause the liver to slow down.

I had a hair mineral analysis which confirmed I had hidden copper toxicity.

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960
(@tryingtohelp2014)

Posted : 01/04/2015 1:00 pm

Phase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involved are a set of transferases which perform the transfer of the cofactor group to the substrate. The resultant conjugation results in greatly increasing the excretory potential of compounds. Although most conjugations result in pharmacological inactivation or detoxification, some can result in bioactivation. Most of the phase II enzymes are located in the cytosol except UDP-glucuronosyltransferases (UGT), which are microsomal. Phase II reactions are typically much faster than phase I reactions therefore the rate-limiting step for biotransformation of a compound is usually the phase I reaction.
Phase II metabolism can deal with all the products of phase I metabolism, be they reactive (Type I substrate) or unreactive/poorly active (Type II substrate) compounds. With the exception of glutathione, the conjugating species needs to be made chemically reactive after synthesis. The availability of the cofactor in the synthesis may be a rate-limiting factor in some phase II pathways as it may prevent the formation of enough conjugating species to deal with the substrate or it's metabolite. As many substrates and/or their metabolites are chemically reactive, their continued presence may lead to toxicity.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=156580

Altogether, these results clearly indicated that the metal
ion binding site of GlcAT-I can accommodate several divalent metal ions but that Mn2+
is the best metal activator of the enzyme.
Kinetic studies of manganese activation of GlcAT-I - In order to analyze the
mechanism underlying Mn2+ stimulation of GlcAT-I activity, detailed kinetic studies of
Mn2+ activation were performed. Initial rates of reaction were measured using varying
concentrations of UDP-GlcA (0 -1 mM) in the presence of different concentrations of
Mn2+ (0 -1 mM) (Fig. 2). Analysis of the results clearly showed that GlcAT-I requires
the metal for activity and that the velocity of the enzyme was remarkably stimulated by
Mn2+ in a range of concentrations up to 1 mM (Fig. 2). In addition, the plots indicated
that Vmax was approached at Mn2+ concentration from 0.5 to 1 mM. Furthermore, no
inhibitory effect at higher Mn2+
Listen, this is root level stuff. This is where the whole process begins. There is no other step that comes before this. Everything else discussed on this thread, from RSO, to niacin, to fatty acids, to vitamin D etc etc etc..... comes AFTER this detoxification process. logically, ALL of these potential "cures" would be treating symptoms only imo. Not saying they cant help, but they arent the "cure." i.e. Vitamin C doesnt bind with 13 cis retinoic acid for excretion. Vitamin D doesnt bind with the 4 oxo metabolite. Olive oil and lemons from a liver flush dont actively bind with a metabolite before it can be reabsorbed. This is where everyone seems to be fumbling around.... they find something that masks one of the many side effects, and they somehow think they found a cure.
The only thing in my mind that needs to be worked out now
1. what dosage? what interval?
2. how long?
3. what else helps in the assimilation and storage of Mn? B2? Choline?
4. will activating the enzyme assist in the residue thats already stored? or does the residue/metabolite have to be actively reintroduced to the bloodstream from a fatty liver, or from stored fat elsewhere? For example, we know fat stored around the abdomen influences hormones just by passively being there...does a stored accutane metabolite influence our epigentics just by being stored, while not being present in the bloodstream?! What ways can we do this? I know extreme prolonged exercise works for sure. fasting?! ketogenic diets? Choline moving fat out of the liver?!
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76
(@yetanotheraccutanevictim)

Posted : 01/04/2015 1:38 pm

Good little brief explanation of detoxification with a small useful chart

(In Terry Wahl's book-great read btw)

EDIT: hmm, sorry, it becomes blurry when I upload it to here..

Here's a good post on the liver detox pathways: link

post-439093-0-14640200-1420396631.jpg

post-439093-0-40919900-1420396635.jpg

post-439093-0-93073200-1420396807.jpg

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70
(@whackutane)

Posted : 01/04/2015 5:37 pm

Im not bovering with reading up on all that conversion stuff, what chemical reactions do what. Like i said the internet can easily over complicate things and it just leaves you stuck with trying to google shit everyday. While I respect the science I get bored of it very quickly.

I myself am slowly going to start treating my adrenals. Drop down to part time work, get the right supplements, eat the right food, keep going with PMO reboot, and yeah just continue to chill.

Could just be me but it seems to work well.

I feel as though I have had a major reduction in symptoms as well when previously trying certain aspects of my new theory.

So now Im going to go all out.

Will post results here :)

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14
(@youbetterloveyourself)

Posted : 01/04/2015 6:57 pm

black_seed_healing.jpg

This humble, but immensely powerful seed, kills MRSA, heals the chemical weapon poisoned body, stimulates regeneration of the dying beta cells within the diabetic's pancreas, and yet too few even know it exists.

The seeds of the annual flowering plant, Nigella Sativa, have been prized for their healing properties since time immemorial. While frequently referred to among English-speaking cultures as Roman coriander, black sesame, black cumin, black caraway and onion seed, it is known today primarily as black seed, which is at the very least an accurate description of its physical appearance.

The earliest record of its cultivation and use come from ancient Egypt. Black seed oil, in fact, was found in Egyptian pharoah Tutankhamun's tomb, dating back to approximately 3,300 years ago. In Arabic cultures, black cumin is known as Habbatul barakah, meaning the "seed of blessing." It is also believed that the Islamic prophet Mohammed said of it that it is "a remedy for all diseases except death."

Many of black cumin's traditionally ascribed health benefits have been thoroughly confirmed in the biomedical literature. In fact, since 1964, there have been 458 published, peer-reviewed studies referencing it.

We have indexed salient research, available to view on GreenMedInfo.com on our Black Seed (Nigella Sativa) page, on well over 40 health conditions that may be benefited from the use of the herb, including over 20 distinct pharmacological actions it expresses, such as:

  • Analgesic (Pain-Killing)
  • Anti-Bacterial

Anti-InflammatoryAnti-UlcerAnti-CholinergicAnti-FungalAnt-HypertensiveAntioxidantAntispasmodicAntiviralBronchodilatorGluconeogenesis Inhibitor (Anti-Diabetic)Hepatoprotective (Liver Protecting)HypotensiveInsulin SensitizingInterferon InducerLeukotriene AntagonistRenoprotective (Kidney Protecting)Tumor Necrosis Factor Alpha Inhibitor

These 22 pharmacological actions are only a subset of a far wider number of beneficial properties intrinsic to the black seed. While it is remarkable that this seed has the ability to positively modulate so many different biological pathways, this is actually a rather common occurrence among traditional plant medicines.

Our project has identified over 1600 natural compounds with a wide range of health benefits, and we are only in our first 5 years of casual indexing. There are tens of thousands of other substances that have already been researched, with hundreds of thousands of studies supporting their medicinal value (MEDLINE, whence our study abstracts come, has over 600,000 studies classified as related to Complementary and Alternative Medicine).

Take turmeric, for example. We have identified research indicating its value in over 600 health conditions, while also expressing over 160 different potentially beneficial pharmacological actions. You can view the quick summary of over 1500 studies we have summarized on our Turmeric Research page, which includes an explorative video on turmeric. Professional database members are further empowered to manipulate the results according to their search criteria, i.e. pull up and print to PDF the 61 studies on turmeric and breast cancer. This, of course, should help folks realize how voluminous the supportive literature indicating the medicinal value of natural substances, such as turmeric and black seed, really is.

Black seed has been researched for very specific health conditions. Some of the most compelling applications include:

  • Type 2 Diabetes: Two grams of black seed a day resulted in reduced fasting glucose, decreased insulin resistance, increased beta-cell function, and reduced glycosylated hemoglobin (HbA1c) in human subjects.[ii]
  • Helicobacter Pylori Infection: Black seeds possess clinically useful anti-H. pylori activity, comparable to triple eradication therapy.[iii]

Epilepsy: Black seeds were traditionally known to have anticonvulsive properties. A 2007 study with epileptic children, whose condition was refractory to conventional drug treatment, found that a water extract significantly reduced seizure activity.[iv]High Blood pressure: The daily use of 100 and 200 mg of black seed extract, twice daily, for 2 months, was found to have a blood pressure-lowering effect in patients with mild hypertension.[v]Asthma: Thymoquinone, one of the main active constituents within Nigella sativa (black cumin), is superior to the drug fluticasone in an animal model of asthma.[vi] Another study, this time in human subjects, found that boiled water extracts of black seed have relatively potent antiasthmatic effect on asthmatic airways.[vii]Acute tonsillopharyngitis: characterized by tonsil or pharyngeal inflammation (i.e. sore throat), mostly viral in origin, black seed capsules (in combination with Phyllanthus niruri) have been found to significantly alleviate throat pain, and reduce the need for pain-killers, in human subjects.[viii]Chemical Weapons Injury: A randomized, placebo-controlled human study of chemical weapons injured patients found that boiled water extracts of black seed reduced respiratory symptoms, chest wheezing, and pulmonary function test values, as well as reduced the need for drug treatment.[ix]Colon Cancer: Cell studies have found that black seed extract compares favorably to the chemoagent 5-fluoruracil in the suppression of colon cancer growth, but with a far higher safety profile.[x] Animal research has found that black seed oil has significant inhibitory effects against colon cancer in rats, without observable side effects.[xi]MRSA: Black seed has anti-bacterial activity against clinical isolates of methicillin resistant Staphylococcus aureus.[xii]Opiate Addiction/Withdrawal: A study on 35 opiate addicts found black seed as an effective therapy in long-term treatment of opioid dependence.[xiii]

Cancer Prevention
One study found that black seed extracts protected healthy cells and destroyed tumor cells while increasing the levels of antibodies in the body. It also contains antioxidants, boosts the immune system and has anti-inflammatory properties, all key components of cancer prevention.

High In Antioxidants
Black seed oil contains powerful antioxidants that help prevent oxidative stress to cells and the cardiovascular system, including thymoquinone, which has shown to protect against heart, liver and kidney disease in animal studies.

Anti-Inflammatory
Studies show that black seed oil can help reduce inflammation. Applied topically, black seed oil can ease the pain of cramps and relieve muscles spasms.

Antihistamine
A natural antihistamine, black seed oil has been shown to destroy microorganisms in lab tests.

Antibacterial
Research shows black seed oil has the ability to destroy different bacterial agents in the digestive tract, including candida and E. coli.

Blood Pressure
Several studies have shown that the substances in black seed oil can help reduce blood pressure.

Immune System Support
Many health officials claim that black seed oil boosts the immune system by increasing immune reactions and the production of antibodies.

Allergy Relief
A study of 152 patients in 2003 showed that black seed oil helped reduce symptoms of allergies and may be an effective treatment for allergic reactions. Another study of 600 patients found that black seed oil relieved allergy symptoms in 70% of the cases.
¨
Diabetes
One study found that black seed oil helped reduce blood sugar levels. This may help diabetics balance glucose and insulin levels after meals.

Respiratory Health
Black seed oil has been shown to be effective for treating asthma and reducing the symptoms of respiratory infections like coughs and bronchitis.

¨Digestive Aid
Black seed oil helps the body process toxins, stimulates stomach bile and can act as a laxative.

Insomnia
Studies show black seed oil can help eliminate sleep disorders when taken internally before going to bed.

Healthy Skin
Black seed oil may be an effective treatment for chronic acne.

NOTE: I have taken Black Seed Oil, 1 tsp a day for just a week. Already my ED symptoms are MUCH better. With Increased ejaculate.

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9
(@vianello)

Posted : 01/04/2015 7:16 pm

Fibroscan - would be a non invasive alternative option to see if one suffers from cirrhosis. It could very well be that some part of the liver formed scaring- a fatty liver would have probably resolved itself - hence are healthy life styles:)

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MemberMember
14
(@youbetterloveyourself)

Posted : 01/04/2015 7:22 pm

Riddle me this.

If Roche claims accutane side effects are long lasting. Possibly even 50 years.

The answer is why??!?

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MemberMember
20
(@cbar1516)

Posted : 01/05/2015 12:42 am

New here!

 

Wish I never had any reason to discover this thread, but here I am.

 

23 y/o white male, 150 lbs, took a course of Accutane from Feb - April 2013. 40 mg daily.

 

Was supposed to be a four month course, but I quit a month early due to horrible anxiety (never had before in my life. Woke up one day and my brain was stuck in fight-or-flight and wouldn't turn off).

 

Ended up being put on Clonazepam, became horribly dependant upon that within 4 weeks. I thought Accutane-induced anxiety was bad; it's got nothing on benzo withdrawal. Ended up on Prozac for a year (slowly tapered off to avoid side effects).

 

Thought the whole ordeal was worth it (at first), until my beautiful glowing new face slowly morphed into a hyper pigmented, wrinkly, tight piece of shit (they don't warn you about that side effect). My hair began falling out about four months after the course ended, and continues to shed to this day with increasing severity.

 

This past three months things have taken a big turn for the worst. Hair loss was no longer my biggest concern, because I started experiencing back pain. And my joints began clicking and cracking (never did before). And then they all started hurting. The transformation from healthy-ish adult to human-kettle-corn-machine was disturbingly fast. Being the (not-so) hypochondriac that I am, and knowing what Accutane can do, I immediately went to my (new) GP (left the old one at the curb after Accutane, obviously). Diagnosed with inflammatory arthritis (neg rheum factor) after x-rays showed "slight demineralization" in my hands. The debilitating fatigue came shortly afterwards. Currently in the process of undergoing a trillion tests to figure what's going on exactly.

 

I am not healed. If anything, I'm getting worse. That said, I have learned a thing or two that anyone else suffering from PAS might benefit from.

 

1) Diet!!! My diet since being on Accutane has been abysmal, which I'm pretty sure has contributed to my currently declining health. If we're survive, we need to treat ourselves well. No processed food. No caffeine. No booze. No sugar. No fat. No salt. No corn syrup. Only water and green tea (like our ancestors). A good diet won't heal us, but it'll stop us from getting worse faster.

 

2) SSRIs. A necessary evil. Accutane ravaged my serotonin receptors, and life sucks with low serotonin. The sexual side effects are not ideal, but they're preferable to living in my own mental Hell. Prozac does an amazing job of allowing me to not dwell so much on the negative aspects of what I'm dealing with (which, as I'm sure you all know, can be very all-consuming and overwhelming).

 

3) WEED!!! Seriously, it's a REAL miracle drug. It won't "cure" you, but I guarantee you'll be in better shape after six months of use. I get medical (bless Canada), and highly recommend marijuana capsules. 0.5% THC 21% CBD is my preference. Take those daily and supplement with eadibles and

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180
(@roland1968)

Posted : 01/05/2015 3:59 am

Riddle me this.

If Roche claims accutane side effects are long lasting. Possibly even 50 years.

The answer is why??!?

where is Roche claiming this? Do you have a source?

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MemberMember
9
(@vianello)

Posted : 01/05/2015 8:26 am

http://europepmc.org/abstract/MED/14978883

 

This is what happens in our livers- or something close!!!

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