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On 12/13/2014 at 8:44 AM, tryingtohelp2014 said:On 12/13/2014 at 6:39 AM, Antoniorgr said:Maybe off topic but I feel the need to thank you all
I've been prescribed Accutane (or Roacutan in my country. Isotretinoin) this week because of a bad seborreic dermatitis.
Since Im with this dermatitis so bad first because of a Differin cream bad reaction, then got worse because of protopic cream (prescribed to cure the differin bad reaction) this time I went to do some research on the internet before I use the meds.
First of all, I'm very very sorry you guys are experiencing this. I really hope everybody get better and find a proper cure for it.
Second, thank you very much for the warnings and all information here. If it where not your warnings maybe it would be me tomorrow.
There is not a single word about this anywhere on my country.
Today was day 4 on my treatment, I took 40mg/day this week.
4 days of accutane.
I hope this was not enough to affect me.
I won't take it anymore.
I'll get back to the derm this week and ask for another alternative to treat me. Creams, laser, etc, not accutane.
My best wishes to all of you
Biotin supplementation, in doses of 1-10 mg/day has been shown to heal most rashes within weeks, even in severe cases of seborrheic dermatitis.17 Breast-fed infants with seborrheic dermatitis improved dramatically when their malnourished mothers were given biotin injections, and in other cases when the infants themselves were supplemented with biotin.52 However, this data is inconclusive since biotin was found to be ineffective in a double-blind clinical trial, suggesting that biotin deficiency may not always be the cause of seborrheic dermatitis in infants.18,53
It may be a good idea to take manganese with biotin for best results. Experts suggest that manganese indirectly supports biotin in its healing effects for certain skin conditions (e.g., psoriasis and acne). Biotin needs certain enzymes to function in the skin that manganese helps to activate.54
many many people here have accutane induced seborrheic dermatitis
for all of you who are starting to take manganese... its very important to take choline as well. again, read what "doglover" says in this thread [Edited link out]
"
Here's another example - I have a client that was diagnosed with Lou Gehrig's. He never took a manganese supplement and never even ate many foods that contained manganese like rice, hazel nuts, coconut and pineapple. He did participate in triathalons for 28 years of his life. High stress and muscle use with sweating depletes the body of choline. Without adequate choline, you can not store manganese in the liver. This mans chart was off the scale for manganese. After supplementing him with choline and over 300 mg/day of manganese for 8 weeks - his manganese levels have returned to normal on the hair chart. If manganese toxicity was occurring - then based on what the other person wrote - his new hair test should indicate unbelievable levels of manganese. Instead, he is feeling much better, all muscle twitching has stopped (the type of ER in the muscles that takes up calcium was also malfunctiong and the excess calcium keeps the muscles activiated), stools have returned to normal color and consistency and energy levels are back up."
This is from one of his posts.
300 manganese a day ? Isn't that toxic levels were speaking of ? 300 mg choline is a normal dose though.
pretty sure they meant 300 mg of choline
http://www.biotin.com/dosage/safety/dosage-recommendations-for-biotin
Higher amounts of biotin have been prescribed for conditions such as diabetes and biotinidase deficiency. Some experts suggest taking manganese with biotin for best results when taken to help clear skin conditions, since biotin needs certain enzymes to function in the skin that manganese helps to activate.1, 54
The Enlightenment (1650-1776). The addendum (November 2014):
"This is where the 100% wrong, and where the cure is. There is no such thing as a "permanent altered gene expression." DNA is the permanent blueprint......gene expression constantly becomes altered over time. Methylation is controlled by the B-vitamin group. B-vitamins need co-factors to begin to work co-factors include manganese needed for B1 Biotin and Choline to even begin to work."
------------ QUOTE ----------
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
http://ghr.nlm.nih.gov/gene/SUOX
''Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain.''
iron problem from accutane been broth up . the iron might be deficient acording to some science reported cases, or another option (according to internet forum info which might be wrong. messege 32- http://forums.phoeni...ou.15209/page-2 ) iron can be unusable because of an manganese deficency ,this manganese is needed for iron to be relase from the liver,and the manganese deficincy can be beucase of b2 deficency.
so is it the manganese and b2 that being more needed, or the molybdenum itself is deficient also?
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
-----------------------------
some of DUULs sides were interesting... all to me indicate collagen/Mn thyroid/Mn deficiency:
-Minor Tintinitus (slight ringing of ears) Ears tested: Hearing is fine.
- TMJ / Jaw clicking (hurts to yawn sometimes)
- Cracking joints such as Knees and thumbs. (loud knee cracks, thumbs always want to crack)
- Low Libido
-Eye floaters (happened 3 years after accutane)
-Dry Eyes (sometimes they are in the way, my eyes are never white - always some pinkness or eye irritation)
-Changes in Body Temperature, Sometimes feet are ice cold, other parts of my body are warm.
It just said LOW on Moly. that's it.
if you dont try 10mg of manganese daily with that list of symptoms...youre crazy.
pretty sure they meant 300 mg of choline
http://www.biotin.com/dosage/safety/dosage-recommendations-for-biotin
Higher amounts of biotin have been prescribed for conditions such as diabetes and biotinidase deficiency. Some experts suggest taking manganese with biotin for best results when taken to help clear skin conditions, since biotin needs certain enzymes to function in the skin that manganese helps to activate.1, 54
Yeah I think he meant 300 mg of choline.
Btw, the accutane didn't affect your thinking ( brain fog ) or did it ? Because you said you were a 2300 rated chess player.
Another update. My current supplements are:
Manganese 12.5mg/day (a 25mg split in half)
Biotin 3000 mcg? a day... perhaps more would be beneficial.
Milk Thistle - 500mg a day
THe dryness is now over my entire body. Redness around my temples is reducing. The red patch on my right cheek still remains (not sure if rosescea or eczima). Walking feels easier. I feel like I am actually using my muscles to walk instead of putting pressureon my joints. Shoulders still feel like a bunch of rocks rolling around in the drier. Lower back pain sstill feels reduced.
Question, do you guys think the choline in milk thistle is sufficient?
I was also considering starting zinc supplements along with the manganese. Before the zinc didn't really work. Im also trying to increase my vitamin C now that I have manganese in my system...lots of oranges 
.
Another update. My current supplements are:
Manganese 12.5mg/day (a 25mg split in half)
Biotin 3000 mcg? a day... perhaps more would be beneficial.
Milk Thistle - 500mg a day
THe dryness is now over my entire body. Redness around my temples is reducing. The red patch on my right cheek still remains (not sure if rosescea or eczima). Walking feels easier. I feel like I am actually using my muscles to walk instead of putting pressureon my joints. Shoulders still feel like a bunch of rocks rolling around in the drier. Lower back pain sstill feels reduced.
Question, do you guys think the choline in milk thistle is sufficient?
I was also considering starting zinc supplements along with the manganese. Before the zinc didn't really work. Im also trying to increase my vitamin C now that I have manganese in my system...lots of oranges .
Tryingtohelp recommended the A-GPC version of choline.
Go to iHerb or Amazon and type in A-GPC. it is an "expensive" version of choline. There is also an CDP version of choline and they borth work different. The one recommended is A-GPC.
There are also different versions of Manganese, we are looking for the manganese amino acid chelate.
------------ QUOTE ----------
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
http://ghr.nlm.nih.gov/gene/SUOX
''Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain.''
iron problem from accutane been broth up . the iron might be deficient acording to some science reported cases, or another option (according to internet forum info which might be wrong. messege 32- http://forums.phoeni...ou.15209/page-2 ) iron can be unusable because of an manganese deficency ,this manganese is needed for iron to be relase from the liver,and the manganese deficincy can be beucase of b2 deficency.
so is it the manganese and b2 that being more needed, or the molybdenum itself is deficient also?
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
-----------------------------
some of DUULs sides were interesting... all to me indicate collagen/Mn thyroid/Mn deficiency:
-Minor Tintinitus (slight ringing of ears) Ears tested: Hearing is fine.
- TMJ / Jaw clicking (hurts to yawn sometimes)
- Cracking joints such as Knees and thumbs. (loud knee cracks, thumbs always want to crack)
- Low Libido
-Eye floaters (happened 3 years after accutane)
-Dry Eyes (sometimes they are in the way, my eyes are never white - always some pinkness or eye irritation)
-Changes in Body Temperature, Sometimes feet are ice cold, other parts of my body are warm.
It just said LOW on Moly. that's it.
if you dont try 10mg of manganese daily with that list of symptoms...youre crazy.
Hey Buddy, considering you should be EATING that manganese anyway. Such as almonds, pumpkin seeds, beans, and fish.
Oh how bout that spinach.
First of all name calling here is what has pissed people off in the past and they are gone now.
http://www.healthaliciousness.com/articles/foods-high-in-manganese.php
If people really want to heal themselves. Start injecting HGH or IGF1 into your system. Which is my next step.
It is going to take DRASTIC measures to heal ourselves.
------------ QUOTE ----------
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
http://ghr.nlm.nih.gov/gene/SUOX
''Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain.''
iron problem from accutane been broth up . the iron might be deficient acording to some science reported cases, or another option (according to internet forum info which might be wrong. messege 32- http://forums.phoeni...ou.15209/page-2 ) iron can be unusable because of an manganese deficency ,this manganese is needed for iron to be relase from the liver,and the manganese deficincy can be beucase of b2 deficency.
so is it the manganese and b2 that being more needed, or the molybdenum itself is deficient also?
TO MEMBER DUUL.
if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you
-----------------------------
some of DUULs sides were interesting... all to me indicate collagen/Mn thyroid/Mn deficiency:
-Minor Tintinitus (slight ringing of ears) Ears tested: Hearing is fine.
- TMJ / Jaw clicking (hurts to yawn sometimes)
- Cracking joints such as Knees and thumbs. (loud knee cracks, thumbs always want to crack)
- Low Libido
-Eye floaters (happened 3 years after accutane)
-Dry Eyes (sometimes they are in the way, my eyes are never white - always some pinkness or eye irritation)
-Changes in Body Temperature, Sometimes feet are ice cold, other parts of my body are warm.
It just said LOW on Moly. that's it.
if you dont try 10mg of manganese daily with that list of symptoms...youre crazy.
Hey Buddy, considering you should be EATING that manganese anyway. Such as almonds, pumpkin seeds, beans, and fish.
Oh how bout that spinach.
First of all name calling here is what has pissed people off in the past and they are gone now.
http://www.healthaliciousness.com/articles/foods-high-in-manganese.php
If people really want to heal themselves. Start injecting HGH or IGF1 into your system. Which is my next step.
It is going to take DRASTIC measures to heal ourselves.
wait a second... youre going to take an illegal human growth hormone instead of trying a mineral supplement?! again, thats crazy
and if the natural sources from food worked, i wouldve been fixed 15 years ago. it needs to be more drastic...youre right about that part.
Also I am not going to be using HGH but peptides, which are legal when you reconstitute the peptides.
You can also stimulate your body to produce more HGH with certain supps.
No. Nothing is crazy at this point, not doing anything is crazy.
More common
- Fever
- Chills
- Shivering
- General feeling of discomfort
- Depression
- Cough or cough with mucus
- Runny nose
- Sore throat
- Wheezing
- Hoarse or husky voice
- Shortness of breath
- Back pain
- Trouble sleeping
- Difficulty breathing
- Weight gain
- Ear congestion
- Dry skin or hair
- Hair loss
- Increased hunger
- Constipation
- Diarrhea
- Loss of appetite
- Difficulty moving
- Pain in the joints
- Altered heartbeat
- Severe headaches
- Heart enlargement
- Ear infections or ear problems
- Dizziness
- Nervousness
- Nervousness
- Pounding in the ears
- Itching, numbness, tingling, burning or crawling sensations throughout the body
- Blurred vision
- Altered touch sensations
- Premature death
- Low blood sugar
some of the side effects of HGH. looks like a lot of the ones people are trying to solve here. besides having nothing to do with 13-cis retinoic acid clearance, and adding yet another substance that damages the liver.... way to think around the illegality of the whole thing though!
Sounds like the side effects of....anything really. I was diagnosed with a Pitutary gland deficiency as a kid and took HGH through my Endocrinologist.
I took it for about 6 years because my growth was stunted, it helped and I did not get any of those side effects accept for... Acne. Which is why I took accutane.
HGH and IGF-1 if anything can bring cell repair, anti-aging, anti-wrinkling effects to skin. Also repair to creaking joints, collagen loss. Hair GROWTH. Not hair loss.
Possibly even bring back the oil we need for our skin. Man I would love that.
Where is your proof that livers are damaged when read out's on blood work are fine?
Everytime someone posts an article on "Accutane is still in our bodies." there is one that does the opposite.
I think it's as simple as this. It's done. The 13-cis retinoic acid epigentically modified on how are genes are expressed and was taken OUT of the body.
The damage is done. And taking your little manganese won't do anything. There is nothing to detox, it's already done.
It's going to take HARDCORE genetic modification of our cells to get back to what we were. Which is what I will do next.
Sounds like the side effects of....anything really. I was diagnosed with a Pitutary gland deficiency as a kid and took HGH through my Endocrinologist.
I took it for about 6 years because my growth was stunted, it helped and I did not get any of those side effects accept for... Acne. Which is why I took accutane.
HGH and IGF-1 if anything can bring cell repair, anti-aging, anti-wrinkling effects to skin. Also repair to creaking joints, collagen loss. Hair GROWTH. Not hair loss.
Possibly even bring back the oil we need for our skin. Man I would love that.
Where is your proof that livers are damaged when read out's on blood work are fine?
Everytime someone posts an article on "Accutane is still in our bodies." there is one that does the opposite.
I think it's as simple as this. It's done. The 13-cis retinoic acid epigentically modified on how are genes are expressed and was taken OUT of the body.
The damage is done. And taking your little manganese won't do anything. There is nothing to detox, it's already done.
It's going to take HARDCORE genetic modification of our cells to get back to what we were. Which is what I will do next.
You dont understand epigenetics then. There is no "done" damage. Epigenetic changes arent permanent in any way. There needs to be an ACTIVE suppressor of the gene....otherwise, it would default back to our original DNA blueprint. your DNA never changes. My "little" manganese is the mineral that activates the enzyme to glucuordinate retinoid metabolites out of the body.
How is your gene currently being silenced if there is nothing( accutane metabolite) to silence it???
Plus, if you believe in hardcore epigenetic changes, you would be taking the methylating B vitamins
- As there is a significant amount of manganese in the pituitary gland, where sex hormones are manufactured, it is known to play a part in sexual function.
I've been taking 2.5 mg manganese pills and I wonder is it safe to take multiple pills per day when the package says you can't increase the daily 2.5 mg dose. Maybe these pills have some other ingredient which dose you can't increase. I would write the ingredients, but I have no idea what they are in english.
I have also wondered would HGH help me, because I have low GH levels, but my doctor said something like it doesn't matter, because my IGF levels are good and he wouldn't prescribe HGH anyways for my symptoms.
You dont understand epigenetics then. There is no "done" damage. Epigenetic changes arent permanent in any way. There needs to be an ACTIVE suppressor of the gene....otherwise, it would default back to our original DNA blueprint. your DNA never changes. My "little" manganese is the mineral that activates the enzyme to glucuordinate retinoid metabolites out of the body.
How is your gene currently being silenced if there is nothing( accutane metabolite) to silence it???
Plus, if you believe in hardcore epigenetic changes, you would be taking the methylating B vitamins
- As there is a significant amount of manganese in the pituitary gland, where sex hormones are manufactured, it is known to play a part in sexual function.
You have a skewed perspective of epigenetics bro.
Understanding is as easy as googling:
https://en.wikipedia.org/wiki/Epigenetics
Alterations CAN be permanent and there does not have to be a factor actively suppressing trasncription. What about DNA methylation and chromatin modifications, which could easily explain long-term side effects without the drug still being present? I guess it's just easier to believe that flushing something out that there is no valid reason to believe is still present will lead to a solution.
Epigenetic alterations being passed-down through family lines:
http://www.naturalhistorymag.com/features/142195/beyond-dna-epigenetics
http://www.popsci.com/article/science/how-nutrition-one-generation-can-change-genetics-next
Duul said he was prescribed HGH because of a pre-existing pituitary hormone deficiency, not because of anything Accutane may have done. Sounds like a responsibly prescribed treatement, eh? WTF does manganese have to do with his particular case.
Hey Dull, did your doctors think the pituitary deficiency had anything to do with the Chiari malformation?
Did you have any deficiencies of FSH/LH, ACTH, or TSH along with low GH levels?
Excellent theory paper discussing possible epiegenetic origins of many persistent side effects of Accutane:
The 5ARI Withdrawal Syndrome(5ARI-WS)
http://www.protocol-online.org/forums/uploads/monthly_08_2010/msg-19273-027408800%201282061244.ipb
Much of it has been observed to be true of PFS patients in a laboratory setting since the paper was submitted.
This is especially interesting considering the number of us who have been stuck with sexual and depressive/cognitive symptoms since taking Accutane.
Pido: You may want to seriously reconsider finasteride.
The problem is, I do still get erect however not like when I was 18. It could be AGE related tho.
Or the lack of androgen recetors to the testosterone. Which I will do blood work to test them soon.
I am still fertile with a high sperm count.
I think anyone taking Finasteride is complete and total suicide. Do not go down that route. It's just not worth it at this point.
Also for the B Vitamins, will B12 injections work best?
You dont understand epigenetics then. There is no "done" damage. Epigenetic changes arent permanent in any way. There needs to be an ACTIVE suppressor of the gene....otherwise, it would default back to our original DNA blueprint. your DNA never changes. My "little" manganese is the mineral that activates the enzyme to glucuordinate retinoid metabolites out of the body.
How is your gene currently being silenced if there is nothing( accutane metabolite) to silence it???
Plus, if you believe in hardcore epigenetic changes, you would be taking the methylating B vitamins
- As there is a significant amount of manganese in the pituitary gland, where sex hormones are manufactured, it is known to play a part in sexual function.
You have a skewed perspective of epigenetics bro.
Understanding is as easy as googling:
https://en.wikipedia.org/wiki/Epigenetics
Alterations CAN be permanent and there does not have to be a factor actively suppressing trasncription. What about DNA methylation and chromatin modifications, which could easily explain long-term side effects without the drug still being present? I guess it's just easier to believe that flushing something out that there is no valid reason to believe is still present will lead to a solution.
Epigenetic alterations being passed-down through family lines:
http://www.naturalhistorymag.com/features/142195/beyond-dna-epigenetics
http://www.popsci.com/article/science/how-nutrition-one-generation-can-change-genetics-next
Duul said he was prescribed HGH because of a pre-existing pituitary hormone deficiency, not because of anything Accutane may have done. Sounds like a responsibly prescribed treatement, eh? WTF does manganese have to do with his particular case.
Hey Dull, did your doctors think the pituitary deficiency had anything to do with the Chiari malformation?
Did you have any deficiencies of FSH/LH, ACTH, or TSH along with low GH levels?
I will dig through my old medical records tonight and see if I can find some numbers.
I believe my friend it's all related. The doctors never could come to an exact conclusion.
Whoops, looks like the original link was bad:
The 5ARI Withdrawal Syndrome:
http://www.protocol-online.org/forums/uploads/monthly_08_2010/msg-19273-027408800%201282061244.ipb
I will dig through my old medical records tonight and see if I can find some numbers.
I believe my friend it's all related. The doctors never could come to an exact conclusion.
If Accutane caused you any sexual symptoms you would most likely know it. For most of us with sexual symptoms, it goes from having a fully charged sex drive, being fully functional and ready to go at any moment, to having numb broken-down genitals and almost an absent libido in a relatively short time frame during or soon after taking Accutane. Suicidal depression and/or wiped-out emotions often accompany this. It's shocking and terrifying. If you think it boils down to aging in your case, then it may be so.
There are no conventional tests available for androgen-receptor levels either. Not sure why it's such a big deal to take a small tissue sample to perform molecular testing, but it is. That seems to be one of the huge hurdles we face. No matter what exactly Accutane did to us, very little has been determined from blood tests, and the types of tests we would need to show changes in gene expression or epigenetic markers are not performed outside of a research setting.
You dont understand epigenetics then. There is no "done" damage. Epigenetic changes arent permanent in any way. There needs to be an ACTIVE suppressor of the gene....otherwise, it would default back to our original DNA blueprint. your DNA never changes. My "little" manganese is the mineral that activates the enzyme to glucuordinate retinoid metabolites out of the body.
How is your gene currently being silenced if there is nothing( accutane metabolite) to silence it???
Plus, if you believe in hardcore epigenetic changes, you would be taking the methylating B vitamins
- As there is a significant amount of manganese in the pituitary gland, where sex hormones are manufactured, it is known to play a part in sexual function.
You have a skewed perspective of epigenetics bro.
Understanding is as easy as googling:
https://en.wikipedia.org/wiki/Epigenetics
Alterations CAN be permanent and there does not have to be a factor actively suppressing trasncription. What about DNA methylation and chromatin modifications, which could easily explain long-term side effects without the drug still being present? I guess it's just easier to believe that flushing something out that there is no valid reason to believe is still present will lead to a solution.
Epigenetic alterations being passed-down through family lines:
http://www.naturalhistorymag.com/features/142195/beyond-dna-epigenetics
http://www.popsci.com/article/science/how-nutrition-one-generation-can-change-genetics-next
Duul said he was prescribed HGH because of a pre-existing pituitary hormone deficiency, not because of anything Accutane may have done. Sounds like a responsibly prescribed treatement, eh? WTF does manganese have to do with his particular case.
Hey Dull, did your doctors think the pituitary deficiency had anything to do with the Chiari malformation?
Did you have any deficiencies of FSH/LH, ACTH, or TSH along with low GH levels?
I will dig through my old medical records tonight and see if I can find some numbers.
I believe my friend it's all related. The doctors never could come to an exact conclusion.
i dont see anything in my statement that wasnt correct?
epi- (Greek: - over, outside of, around)
epigenetics is the study of cellular and physiological traits that are heritable by daughter cells and not caused by changes in the DNA sequence
Gene expression can be controlled through the action of repressor proteins that attach tosilencer regions of the DNA. These epigenetic changes may last through cell divisions for the duration of the cell's life, and may also last for multiple generations even though they do not involve changes in the underlyingDNA sequence of the organism;[4] instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently.
repressor proteins:
If an inducer, a molecule that initiates the gene expression, is present, then it can interact with the repressor protein and detach it from the operator. RNA polymerase then can transcribe the message (expressing the gene)
Im sorry to be blunt...but as far as Duul's case... he takes prescribed HGH (because we all know prescriptions from doctors make it all good) , has this prescription make his face so bad, it makes him take the chemo drug accutane... now come full circle, to think taking HGH again will solve all of the problems?! that is beyond any logic i see. Maybe that doctor, instead of just prescribing HGH, shouldve found out why he why low in HGH to begin with,,, then he wouldve never even heard of accutane.
.....
http://www.dcnutrition.com/Minerals/detail.cfm?RecordNumber=80
Manganese, as a specific activator of glycosyltransferases, may also affect glycosylation of glycoproteins on cell membranes including receptors. This would alter receptor composition and structural properties and affect lipoprotein binding and their ultimate metabolic fate.
Modulation by all-trans retinoic acid of glycoprotein glycosylation in murine melanoma cells: enhancement of fucosyl- and galactosyltransferase activities.
[Edited link out]
@tryingtohelp
You dont understand epigenetics then. There is no "done" damage. Epigenetic changes arent permanent in any way. There needs to be an ACTIVE suppressor of the gene....otherwise, it would default back to our original DNA blueprint. your DNA never changes. My "little" manganese is the mineral that activates the enzyme to glucuordinate retinoid metabolites out of the body.
How is your gene currently being silenced if there is nothing( accutane metabolite) to silence it???
Plus, if you believe in hardcore epigenetic changes, you would be taking the methylating B vitamins
Implying that Accutane or a metabolite of Accutane must be present to alter gene expression is incorrect in the context of the wikipedia article quoted. This would not be considered an epigentic alteration, but an active modulator of gene expression.
The offending substance does not need to be present for the gene to be silenced. ..."The damage is done," so to speak.
Is there a way to correct it? Maybe. Is taking B-vitamins that may promote methylation going to correct it? Who knows.
That's assuming hypomethylation of a gene or genes is the underlying problem.
And in Duul's case, supplementing a natural hormone that he is lacking due to a structural abnormality sounds like a good idea.