symptoms? All. Joint, skin, focus, genitalia, i had em all.

 

i am recovering from post accutane problems, i did so by applying tons of grape seed oil (high in linoleic acid) to my upper arms (especially triceps where the red bumps were) and experienced muscle twitches shortly afterward. since then I've been recovering a little each day, i kid you not, nothing worked for years until i came up with this shot in the dark. I only had to apply it once (1/4 cup should do), you'll know when your recovering. it took two years for it to come on and it will take two years to go away, I'm hallway through and recovering everyday. good luck to you all. Pass this on!

wait, so you applied a 1/4 cup of grape seed oil to your upper arms for only one day, and never again since?

thats correct, i didn't need anymore because i could feel the recovery. just do it man

thats correct, i didn't need anymore because i could feel the recovery. just do it man

sounds crazier than anything annoy said, but i will try this before anything he recommends

applied one time, qtr cup

joints stopped hurting?

skin got better/more oily?

brain fog lifted?

it is a carrier oil. loaded with Vitamin D E , beta carotene?! maybe some type of trans dermal absorption thing going on here.

 

thats correct, i didn't need anymore because i could feel the recovery. just do it man

sounds crazier than anything annoy said, but i will try this before anything he recommends

applied one time, qtr cup

joints stopped hurting?

skin got better/more oily?

brain fog lifted?

it is a carrier oil. loaded with Vitamin D E , beta carotene?! maybe some type of trans dermal absorption thing going on here.

Sounds too crazy to be honest. Applied only once and all sides are gone?

How long did you have accutane side effects before taking grape seed oil and what side effects did you exhibit? Also how long ago did you start on accutane?

ct11111

Out of interest has this grape seed experiment been carried out in the last couple of weeks to one month?

I had a quick google of grape seed extract to see if it had any relation with 5-alpha reductase. A bunch of anti-hairloss sites showed up, suggestive that it might be. The fact you mention 'muscle twitches' occurring shortly afterwards as well lends credence to a 5AR based mechanism, although it is by no means proof.

It's noted that a few people who are post-'tane/propecia and take a 5AR inhibitor experience a temporary recovery of sorts before it tapers off and disappears, usually within a month.

I hate to be the negative/pessimistic one, but a sceptical ear is needed on this thread. Not trying to rain on your parade, just trying to rule out certain things.

It's odd to note that a lot of recoveries come via anti-androgenic processes whether it be: fasting, cannabis, re-using propecia, pregnenolone etc. Anonny's vegan diet could also be considered anti-androgenic. (anonny I know you sent me the video of the raw vegan bodybuilder, but in all honesty he just looked like a slightly lean endomorph).

http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes

For those interested in the epigenetic side of things.

To summarise:

i) Epigenetic modifications can be passed from generation to generation
ii) Epigenetic changes vary in intensity i.e. some things cause smaller more transient changes, others, larger more chronic changes
iii) There are already drugs out there that are known demethylators i.e they wipe the slate clean
iv) It is not known what kind of side effects could occur as a result.

A common criticism of the epigenetic theory explaining our sides from 'tane is that a lot of things effect epigentics. So why should Accutane have an effect and not others..? Because there are vastly different levels of methylation and how tightly thread they are to the DNA strands affects how intense the effect is and how long it will remain in position.

http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes

 

For those interested in the epigenetic side of things.

 

To summarise:

 

i) Epigenetic modifications can be passed from generation to generation

ii) Epigenetic changes vary in intensity i.e. some things cause smaller more transient changes, others, larger more chronic changes

iii) There are already drugs out there that are known demethylators i.e they wipe the slate clean

iv) It is not known what kind of side effects could occur as a result.

 

A common criticism of the epigenetic theory explaining our sides from 'tane is that a lot of things effect epigentics. So why should Accutane have an effect and not others..? Because there are vastly different levels of methylation and how tightly thread they are to the DNA strands affects how intense the effect is and how long it will remain in position.

excellent article.

so everyone on here saying that accutane permanently does anything to you is wrong. everything can be fixed.

it can only be one of two things......

1. if this drug has altered out epigenetic response, we can fix this. adding methyl groups (b12 b6 methylfolate TMG etc) has been shown to wipe the slate clean!

2. which raises the other possibility... if accutane hasnt altered our epigenetic responses...if adding the methyl groups doesnt help, whats left? out of the thousands of people who took this drug, some get rid of all side effects in time... so again ...logically, accutane doesnt damage us permanently, it doesnt damage our oil glands for ever. oil glands spontaneously turn on again. ive seen it myself years after stopping. some unknown metabolite must still be in us, influencing these side effects, either in the fat, liver, on the receptors or elsewhere.

some unknown metabolite must still be in us, influencing these side effects, either in the fat, liver, on the receptors or elsewhere.

It's either in the fat or bound to the receptor, it's not in the liver and yes it is the cause of the side effects.

Some crucial information on cell turnover rates in the human body:
[Edited link out]

The same information can be found all over the internet and in textbooks. Scientists, religious zealots, atheists, green people, orange people, men, women, children, and naturopathic healers all seem to generally agree on this one thing as well.

The point being:

• The carbon, hydrogen, and oxygen atoms from the Accutane molecule are long gone within ten years,

• Nearly all cells in your body that at one point contained the Accutane molecule are long gone within ten years.

• That's not even taking into consideration cellular mechanisms like CYP enzymes and glucuronidation that actively deactivate and remove the Accutane molecule from your body.

(Don't forget about CYP26 , a.k.a: human retinoic acid 4-dehydroxylase, in particular) ^

...unless... .....

I propose know for a fact that a homeopathic feedback mechanism is the cause of all long term side effects. The more diluted the Accutane gets, the more potent it's homeopathic imprint on H₂O in the body. So, the effects of Accutane can remain for years after without any being left inside us.

Stop drinking water everyone!!! It cured me and it will cure you too.

Tryingtohelp14, my kudos to you if annoy doesn't return! I'll miss the resident troll. ...nah.

On 10/15/2014 at 7:16 AM, Chico Esposito said:

On 10/15/2014 at 5:48 AM, tryingtohelp2014 said:

some unknown metabolite must still be in us, influencing these side effects, either in the fat, liver, on the receptors or elsewhere.

It's either in the fat or bound to the receptor, it's not in the liver and yes it is the cause of the side effects.

what about instances of a fatty liver?

ive seen people people reporting a rise in liver enzymes only years after taking it.

if its bound to the receptor, how do we get it off?

On 10/15/2014 at 7:37 AM, Dubya_B said:

Some crucial information on cell turnover rates in the human body:

[Edited link out]

The same information can be found all over the internet and in textbooks. Scientists, religious zealots, atheists, green people, orange people, men, women, children, and naturopathic healers all seem to generally agree on this one thing as well.

The point being:

• The carbon, hydrogen, and oxygen atoms from the Accutane molecule are long gone within ten years,

• Nearly all cells in your body that at one point contained the Accutane molecule are long gone within ten years.

• That's not even taking into consideration cellular mechanisms like CYP enzymes and glucuronidation that actively deactivate and remove the Accutane molecule from your body.

(Don't forget about CYP26 , a.k.a: human retinoic acid 4-dehydroxylase, in particular) ^

...unless... .....

I propose know for a fact that a homeopathic feedback mechanism is the cause of all long term side effects. The more diluted the Accutane gets, the more potent it's homeopathic imprint on H₂O in the body. So, the effects of Accutane can remain for years after without any being left inside us.

Stop drinking water everyone!!! It cured me and it will cure you too.

Tryingtohelp14, my kudos to you if annoy doesn't return! I'll miss the resident troll. ...nah.

where is this homeopathic imprint? is it on the cell membrane?

i could agree with this except for one thing.... how does long term extreme exercise bring out diluted homeopathic symptoms? ive experienced this first hand

where is this homeopathic imprint? is it on the cell membrane?

i could agree with this except for one thing.... how does long term extreme exercise bring out diluted homeopathic symptoms? ive experienced this first hand

The imprint is in all the water in your body dude. 2nd law of homeodynamics explains it.

It's probably due to drastically increased ATD -> ATP synthesis during strenuous exercise. Water is a by-product of aerobic ATP synthesis, so the homeopathic imprint gets copied into every water molecule that gets produced.

It is a self-perpetuating system that continues on long after the Accutane is gone.

what about instances of a fatty liver?

ive seen people people reporting a rise in liver enzymes only years after taking it.

if its bound to the receptor, how do we get it off?

Well it can't be stored in the liver because Retinoic acid is the last stage of retinol, it's converted solely for use as a skin cell differentiator and to induce vitamin A toxicity effects in the body in the case of the drug. It can't be retro converted back to retinol, so it doesn't get stored in the liver. Most people with post accutane side effects have bile / gut problems and they are usually skinny, so the chances of them having a fatty liver are quite slim. It's bound in the skin cell receptor and that creates the heightened skin cell turnover, the eliminative organs are usually congested or aren't working properly, hence removal is not optional, so the body stores it to protect the system.

Fasting only gets it out temporarily and it's quite safe because it's bound to fat so the side effects aren't that severe, the problems arise when you eat retinol which forces it out of the receptor and fucks the body up in a major way. For people that have side effects to eating retinol i suggest a 100% vegan diet, no retinol whatsoever. Healing the elimination organs should in theory bring about a reduction in symptom's.

Things like getting the bile flowing optimally, the lymphatic system clean and flowing, cleansing the kidneys and getting sediment out in the urine. These things won't bring your hair back if you've lost it as a result of accutane, it won't heal the scars on your face because of poor wound healing in the past or caused by seb derm or accutane induced psoriasis, but it will theoretically stop the increased skin cell turnover, help joint issues, bring sebum back and as a result give a much healthier glow to the skin. It'll make your hair healthier, not as bone dry, any eye issues like blood shot, dry eyes will subside, mucous membranes will work as they used too, no more nose bleeds or applying vaseline every night to your lips, theoretically of course.

Quit making stuff up.

1) Being skinny doesn't exclude one from having a fatty liver.

2) Retinoic acid has important roles in the brain, eyes, reproductive system, bone, and acts as a transcription factor (gene regulation) throughout the entire body.

3) The body doesn't need to store retinoic acid to protect itself from toxic levels because of the aforementioned CYP26 enzyme which deactivates it.

In fact, excess retinoic acid induces transciprtion of its own catabolic enzyme in the liver: http://www.ncbi.nlm.nih.gov/pubmed/11766909

RA also induces the expression in liver of the mRNA for CYP26, the enzyme that disposes of excess RA by oxidizing RA to 4-oxo-RA. CYP26 is downregulated upon vitamin A depletion.

4) The fat cells that once contained retinoic acid derived from Accutane are gone after several years.

5) What gives you the idea that retinoic acid irreversibly binds to its receptor?

6) And how is it really going to "fuck the body up in a major way" if it's not bound to its receptor because of a competitive inhibitory effect of retinol, since retinoic acid exerts its effects via being bound to the RAR and RXR receptors?

Speaking of congested eliminative organs, this is what severe lymphatic congestion looks like: https://en.wikipedia.org/wiki/Lymphedema

For the thousandth time, a practical explanation for Accutane's long term side effects (These were freshly published.):

 

what about instances of a fatty liver?

ive seen people people reporting a rise in liver enzymes only years after taking it.

if its bound to the receptor, how do we get it off?

Well it can't be stored in the liver because Retinoic acid is the last stage of retinol, it's converted solely for use as a skin cell differentiator and to induce vitamin A toxicity effects in the body in the case of the drug. It can't be retro converted back to retinol, so it doesn't get stored in the liver. Most people with post accutane side effects have bile / gut problems and they are usually skinny, so the chances of them having a fatty liver are quite slim. It's bound in the skin cell receptor and that creates the heightened skin cell turnover, the eliminative organs are usually congested or aren't working properly, hence removal is not optional, so the body stores it to protect the system.

Fasting only gets it out temporarily and it's quite safe because it's bound to fat so the side effects aren't that severe, the problems arise when you eat retinol which forces it out of the receptor and fucks the body up in a major way. For people that have side effects to eating retinol i suggest a 100% vegan diet, no retinol whatsoever. Healing the elimination organs should in theory bring about a reduction in symptom's.

Things like getting the bile flowing optimally, the lymphatic system clean and flowing, cleansing the kidneys and getting sediment out in the urine. These things won't bring your hair back if you've lost it as a result of accutane, it won't heal the scars on your face because of poor wound healing in the past or caused by seb derm or accutane induced psoriasis, but it will theoretically stop the increased skin cell turnover, help joint issues, bring sebum back and as a result give a much healthier glow to the skin. It'll make your hair healthier, not as bone dry, any eye issues like blood shot, dry eyes will subside, mucous membranes will work as they used too, no more nose bleeds or applying vaseline every night to your lips, theoretically of course.

beta-carotene kills me too! if i have pizza or chips and salsa, i feel it in my joints and skin the next day. hard to be on a vegan diet and not consume loads of vitamin A

 

3) The body doesn't need to store retinoic acid to protect itself from toxic levels because of the aforementioned CYP26 enzyme which deactivates it.

In fact, excess retinoic acid induces transciprtion of its own catabolic enzyme in the liver: http://www.ncbi.nlm.nih.gov/pubmed/11766909

RA also induces the expression in liver of the mRNA for CYP26, the enzyme that disposes of excess RA by oxidizing RA to 4-oxo-RA. CYP26 is downregulated upon vitamin A depletion.

then answer why they make you take accutane for 4 months? why would taking it for 4 months be any different than 1 month, or 8 months? or 8 years? why do they have people take certain dosages? if the body self regulates, it simply wouldnt work. its just not that easy.

does accutane trick the body into thinking its depleted of vitamin A thus downregulating the CYP26? does that explain night blindness?

 

 

 

A. M. Urvalek and L. J. Gudas, Retinoic Acid and Histone Deacetylases Regulate Epigenetic Changes in Embryonic Stem Cells, J. Biol. Chem., p. jbc.M114.556555, May 2014.

http://www.jbc.org/content/early/2014/05/12/jbc.M114.556555

Folate and histone methylation again

http://www.sciencedirect.com/science/article/pii/S0083672908004020

Folatemediated onecarbon metabolism is an unusually complex metabolic network, consisting of several interlocking cycles, and compartmentation between cytosol and mitochondria. The cycles have diverse functions, the primary being thymidylate synthesis (the rate limiting step in DNA synthesis), the initial steps in purine synthesis, glutathione synthesis, and a host of methyl transfer reactions that include DNA and histone methylation.

....didnt know MTX cancer drug was an antifolate hmmmm

Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate.

Histone demethylase LSD1 is a folate-binding protein.

 

1) Being skinny doesn't exclude one from having a fatty liver.

2) Retinoic acid has important roles in the brain, eyes, reproductive system, bone, and acts as a transcription factor (gene regulation) throughout the entire body.

3) The body doesn't need to store retinoic acid to protect itself from toxic levels because of the aforementioned CYP26 enzyme which deactivates it.

In fact, excess retinoic acid induces transciprtion of its own catabolic enzyme in the liver: http://www.ncbi.nlm.nih.gov/pubmed/11766909

RA also induces the expression in liver of the mRNA for CYP26, the enzyme that disposes of excess RA by oxidizing RA to 4-oxo-RA. CYP26 is downregulated upon vitamin A depletion.

4) The fat cells that once contained retinoic acid derived from Accutane are gone after several years.

5) What gives you the idea that retinoic acid irreversibly binds to its receptor?

6) And how is it really going to "fuck the body up in a major way" if it's not bound to its receptor because of a competitive inhibitory effect of retinol, since retinoic acid exerts its effects via being bound to the RAR and RXR receptors?

Speaking of congested eliminative organs, this is what severe lymphatic congestion looks like: https://en.wikipedia.org/wiki/Lymphedema

For the thousandth time, a practical explanation for Accutane's long term side effects (These were freshly published.):

A. Urvalek, K. B. Laursen, and L. J. Gudas, The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes. Springer Netherlands, 2014.

http://link.springer.com/chapter/10.1007/978-94-017-9050-5_7

Can't find a full-text version, but you get the idea.

A. M. Urvalek and L. J. Gudas, Retinoic Acid and Histone Deacetylases Regulate Epigenetic Changes in Embryonic Stem Cells, J. Biol. Chem., p. jbc.M114.556555, May 2014.

http://www.jbc.org/content/early/2014/05/12/jbc.M114.556555

Say you have mercury toxicity, if all cells in the body regenerate after 10 years, will the mercury toxicity go away? The answer is no, the cells may get destroyed and created but the molecule remains, unless it's removed via EDTA, coriander, chlorella or various other mercury binding substances via chelation. It's the same thing in this instance, the molecule is still there, and it's not retinoic acid, it's synthetic 13-cis-retinoic acid which is completely different. It's stored whether a new fat cell is created or destroyed, in fact the process of cell apoptosis is completely irrelevant to fat soluble toxin removal.

If your water imprint was true how come juice / water fasting removes the increased skin cell turnover? surely by diluting it (by drinking lots of water / juice) your exponentiating it's effect, but that's blatently not the case, evidenced by the skin condition going away.

 

Has anyone managed to increase or restore bile production? After reading most of the posts here and combining experience from other forums I understand that this is the main problem. Accutane stops the produciton of bile

Hey, I used to post here and bile flow is also the one thing or the most important thing to get going in order to get healthy. I could write a couple of pages why it is so important, you probably already know. From my understanding the most underappreciated function that bile flow brings online is the elimination of heavy metals. For instance mercury elimination is largely achieved via the bile and you may know how disruptive this mercury is to our system.

What helps to promote bile flow and unplug the bile ducts?

Heavy hitters:

- UDCA, take at your own risk, I have experimented with it and it helped a lot, I posted about it on this forum, so...

- liver flushing, it is in the same league as UDCA as far as my experience goes, but it takes a lot more effort and preparation than swallowing a pill, however in my judgement you have less downside risks

- exercise like jump-roping, rowing, anything that stimulated you gallbladder

All-Stars - They may work best in combination, you have to experiment a little, some may take a few weeks (4-8) until you notice that the color of your feces is gradually normalizing etc. and in consequence you get better, symptoms gradually disappear:

- Silymarin

- TMG/Betain

- NAC

- Taurine

- Liv52

I head very good experiences with TMG, Silymarin and Liv52. I overdosed Liv52. Looked at how bodybuilders like to dose this stuff and than dosed accordingly. Lately I have had great success with NAC, it raises glutathion. I would cycle 1200 to 1800 mg taken throughout the day, highly diluted in water, for 2 to 3 months at a time and than get off for a few months.

I'd recommend against taking anything for longer than 3 months at a time and would advice cycling the supplements.

Breaking the enterohepatic cycle is also very critical, I am still working on this part once your bile flow is back online. Hope this helps.

then answer why they make you take accutane for 4 months? why would taking it for 4 months be any different than 1 month, or 8 months? or 8 years? why do they have people take certain dosages? if the body self regulates, it simply wouldnt work. its just not that easy.

does accutane trick the body into thinking its depleted of vitamin A thus downregulating the CYP26? does that explain night blindness?

Maybe because it's a sustained overdose beyond the maximum transcription rate and Vmax of the CYP26 enzyme, and the effects of that overdose state are cumulative? This wouldn't mean that the remainder of the drug isn't rapidly catabolized after one stops treatment, leading to clearance of the drug.

Like pulling the drain plug in a bathtub. The fuller the tub, the faster the water will drain, but it can only drain so fast. In any case, it will all drain out eventually. Think of Accutane dosing as continually filling the tub while it drains, trying to keep the water near the top without it spilling over.

The cause of night blindness while on the drug has yet to be "elucidated", ...get it? .

Anyhow, this paper hypothesizes competitive inhibition of retinol binding to photoreceptors by isotretinoin, but offers nothing definitive:

https://escholarship.org/uc/item/88t998r8

The observation that hypovitaminosis A appears to predispose to nyctalopia begs an explanation in itself. It has been postulated that isotretinoin, in vitamin-A-deficient isotretinoin users, likely binds to the same rod photoreceptors as retinol but does not metabolize to physiologically active rhodopsin and so nyctalopia results, photoreceptor by photoreceptor [3]. There is no experimental proof of this competitive-inhibition hypothesis.

Is Accutane is basically another anti-folate chemotherapy drug that is used to stop cell proliferation by depleting folate like MTX?

Found a good link...a couple of researchers talking back and forth about methylation folate and cancer.

What a coincidence!, just yesterday some arrogant dermatologist who posts in one of the other Accutane forums mentioned methotrexate as a treatment for arthritic symptoms in former Accutane patients.

Also; one of the original, if not THE original, paper showing retinoic acid's potential to induce epigenetic changes studied deviant methylation patterns in the DNA of mice maternally-exposed to RA, which led to cleft-palate formation.

http://www.cpcjournal.org/doi/full/10.1597/07-134.1

Ton's of articles implicating maternal folate-deficiency in cleft palate formation: http://scholar.google.com/scholar?hl=en&q=cleft+palate+folate&btnG=&as_sdt=1%2C39&as_sdtp=

If we're talking about epigenetic change, the remedy is to methylate those changes. Does anyone know how we accomplish that?

Cursory research has turned up dietary methionine, and this: http://www.ncbi.nlm.nih.gov/pubmed/16702343

On 10/15/2014 at 7:14 PM, Chico Esposito said:

Say you have mercury toxicity, if all cells in the body regenerate after 10 years, will the mercury toxicity go away? The answer is no, the cells may get destroyed and created but the molecule remains, unless it's removed via EDTA, coriander, chlorella or various other mercury binding substances via chelation. I

The elimination time of mercury may be very long, but levels decrease over time if intake < excretion. Chelation artificially speeds up elimination, but is not a requirement. The longest estimated half-life of mercury I found in a quick search was ~500 days in brain tissue from dissected monkeys.

There are binding proteins for heavy metals, which participate in elimination: https://en.wikipedia.org/wiki/Metallothionein

A study where a half-life of 26 days was observed in the brains of rats exposed to mercury: http://link.springer.com/article/10.1007/s002040050486

Please investigate your rhetorical questions more thoroughly. Mercury is not forever in living tissue, and there has yet to be a legitimate, evidence-based reason given that an organic molecule like isotretinoin/Accutane would be.

Quote

It's the same thing in this instance, the molecule is still there, and it's not retinoic acid, it's synthetic 13-cis-retinoic acid which is completely different.

[Edited image out]

Oh really? They don't look that different. They're just different isomers. In fact, a portion of isotretinoin is metabolized into ATRA ( "natural" retinoic acid) by flipping that double bonded carbon and attached carboxyl group at the end :

http://www.landesbioscience.com/journals/dermatoendocrinology/MelnikDE3-3.pdf

Isotretinoin is regarded as a prodrug which after isomerizisation to all-trans-retinoic acid (ATrA)

induces apoptosis in cells cultured from human sebaceous glands, meibomian glands, neuroblastoma cells, hypothalamic cells, hippocampus cells, Daltons lymphoma ascites cells, B16F-10 melanoma cells, and neuronal crest cells

Isotretinoin (Accutane) is also a naturally occurring molecule in small concentrations:

http://www.sciencedirect.com/science/article/pii/S0190962201112697

Because 13-cis-retinoic acid is also a naturally occurring retinoid that is present in the circulation, question is raised as to the biochemical mechanism(s) responsible for its pharmacologic efficacy.

Quote

the molecule is still there,

Even etretinate, the most lipophilic retinoid ever prescribed, is undetectable after 3 years, and there is no evidence of interconversion of isotretinoin to etretinate.

https://en.wikipedia.org/wiki/Etretinate

Seeing as the topic of methylation has been reinvigorated here's a study I posted previously:

D'Addario, C., Di Francesco, A., Pucci, M., Finazzi Agro, A., & Maccarrone, M. (2013). Epigenetic mechanisms and endocannabinoid signalling. FEBS Journal,280(9), 1905-1917.

It has also been observed that THC and cannabinol can (a) activate the ERK-MAPK cascade, a crucial event for gene activation during mitosis induction, and (b) inhibit gap-junction intercellular communication, required to relieve growth suppression of cells [107].

Altogether, these results show a new activity of eCBs as transcriptional repressors via epigenetic mechanisms and in, in the search of drugs able to reverse methylation abnormalities, they suggest a possible exploitation of eCB signaling in human diseases where DNA methylation is downregulated.

eCB-mediated transcription involves coordinated interactions of CB receptors with acetylases and deacetylases, methylases and demethylases. In addition, eCBs have the potential to trigger extranuclear signaling that activates several kinase cascades, which either directly modify histone tails or indirectly influence functions and/or recruitment of histone-modifying enzymes.

Indeed, epigenetic alterations are reversible and specific interventions that target different epigenetic pathways might have a major impact on health problems, eventually providing a new avenue for innovative therapeutic approaches.

Also, from that article I posted earlier; there is a drug called Trichostatin A which removes all methylations.
So it seems we have some drugs/supplements to increase methylation and others to decrease. Question is, which is right for us?

Before arguments pop-up again; can we please discuss in a calm/peaceful manner. None of us want to be here spending hours a day on this forum to start with, especially if we're going to have to deal with abuse everytime.

Dubya I've asked you before but I forgot what you said. Do you know whether we are dealing with a case of over or under methylation, or is it a combination depending on which gene is involved? My research is definitely slowed in rate due to RSO.

Furthermore, I think it worth mentioning as I've now spoken to a few individuals now:

I'm sure a few of you will be close to rejoicing at this news but not all of those who use cannabis recover/improve. I've spoken to or seen posts of chronic smokers who have not recovered (2 so far). In addition, I know out of 4 individuals who have used the oil, 1 noticed no benefit.

I don't mean this to say "I'm wrong" (although it is certainly a possibility). I only mention it so people can make an informed decision when deciding whether to use an illicit substance in regards to 'tane sides.