Ok so you are fixed now, magic pill erased all of your issue. You should tell people who have joint problem, libido problem, kidney issue, liver issue, irritable bowels after accutane that everything is a deficiency of folate, you found the magic solution clap clap you'll have the new nobel prize of ignorance.

I believe you really think you found the magic answer and now you are trying to explain every health issue through this gene defect & deficiency fallacy. You'll have to wake up some day. You don't fix genetic "defect" (weakness) even if there is by taking synthetic supplements. There is also other issue than this head area congestion (that you explain with deficiency), there is some cancer out there, etc.. you can't explain everything with your folate, hello.

Ok so you are fixed now, magic pill erased all of your issue. You should tell people who have joint problem, libido problem, kidney issue, liver issue, irritable bowels after accutane that everything is a deficiency of folate, you found the magic solution clap clap you'll have the new nobel prize of ignorance.

I believe you really think you found the magic answer and now you are trying to explain every health issue through this gene defect & deficiency fallacy. You'll have to wake up some day. You don't fix genetic "defect" (weakness) even if there is by taking synthetic supplements. There is also other issue than this head area congestion (that you explain with deficiency), there is some cancer out there, etc.. you can't explain everything with your folate, hello.

im not saying it cures everything..im presenting the known facts of what accutane depletes. you simply have to stop arguing against known facts. ... Unless you can provide me a study showing these intra-cellular levels go back to normal after stopping accutane, i dont want to hear any of your nonsense

Folic acid was added to breads and pastas way back when because they found the link between birth defects and folic acid.... BUT when they did this, they werent aware that a subset of people couldnt process this folic acid. Not only could they not process it, it actually makes these people worse!!! These are the people with the MTHFR defect. Theres a theory out there now that this recent rise in autism and downs syndrome (genetically based) is based on this added supplementation alone, and its tied to MTHFR. They tested these autistic kids , and over 90% of them have a MTHFR defect.

after mapping the human genome and becoming aware of these SNPs, more people are learning and more research is coming out. I bet if everyone on here with long term effects got tested, we would all come back partially defective, and some, with the worst symptoms, VERY defective. So far that is the only explanation on why some people tolerate accutane, chemotherapy drugs...and some people just cant.

I repeated it lot of times now, we don't care about the symptoms, it's just curiosity, we already know about those symptoms and all the studies you posted, it's useless to look at the symptoms to find a cure to the cause, which is always the same for all health issue, the body is just chemistry there is no defect or magic disease which come from nowhere. If there is an issue, don't blame the body, blame what you did to him and the cellular medium.

If kids are autistic it's first because of the vaccine & other toxins+neurotoxins passed from the mother (plus the GMO's now), and then because like you say, after generation and generation of bad habits, our genetic become weaker and weaker, we can reverse it, but not with synthetic drugs or synthetic supplements.

I repeated it lot of times now, we don't care about the symptoms, it's just curiosity, we already know about those symptoms and all the studies you posted, it's useless to look at the symptoms to find a cure to the cause, which is always the same for all health issue, the body is just chemistry there is no defect or magic disease which come from nowhere. If there is an issue, don't blame the body, blame what you did to him and the cellular medium.

If kids are autistic it's first because of the vaccine & other neurotoxins passed from the mother, and then because like you say, after generation and generation of bad habits, our genetic become weaker and weaker, we can reverse it, but not with synthetic drugs or supplements.

youre only proving my point. vaccines contain mercury, and people with this MTHFR defect have a hard time ridding themselves of these heavy metals. why do certain kids have problems after the vaccination, and others dont? thats why some smoke for 50 years with no cancer, others get it after 2 years.

cure the deficiency, cure the problem.

: / you are a lost cause.

It is the L Y M P H A T I C S Y S T E M who get rid of the toxins & other polluants, not the blood, no synthetic nutrient will restore the lymphatic drainage. You can add as many synthetic nutrients as you want, it won't make thing goes away/drained faster.

I repeated it lot of times now, we don't care about the symptoms, it's just curiosity, we already know about those symptoms and all the studies you posted, it's useless to look at the symptoms to find a cure to the cause, which is always the same for all health issue, the body is just chemistry there is no defect or magic disease which come from nowhere. If there is an issue, don't blame the body, blame what you did to him and the cellular medium.

If kids are autistic it's first because of the vaccine & other toxins+neurotoxins passed from the mother (plus the GMO's now), and then because like you say, after generation and generation of bad habits, our genetic become weaker and weaker, we can reverse it, but not with synthetic drugs or synthetic supplements.

genetics (blueprints dont change) the expression of these genes change...we still carry silenced genes that would grow a tail. the environment changes these expressions. the environment is THE BLOOD. that is the definition of epigenetics (something you said you dont believe in by the way) Again, you really need to do more research

annoy = paid troll

There is no sense in what you say. I always said epigenetic is real, whe can't live without genetic/epigenetic, you really don't understand anything of what i say. But i always said we don't care of those epigenetic things, only the body can restore that by itself, no synthetic man made crap will properly restore the balance ever (and especially not long-term). And yes the environment/medium influence gene expression, i said that since a long time ago. And again adding more synthetic nutrients won't help the lymph cleaning this medium in any way.

The body has a balance, you can't add very high amount of articifial isolate without creating more problems.

Already answered that at least 100 times. The solution imply self responsability & patience, most people are too childish to do that, prefer take a magic pill, so anyway no matter what i say, i believe you will not be interested. No one can help you better than yourself. Just take accutane and you'll come again to cry after the treatment. Can't do more at raising awareness that i already do. You follow the path of those who destroy health to get money or you follow nature/physiology who get real results, your choice now.

There is no sense in what you say. I always said epigenetic is real, whe can't live without genetic/epigenetic, you really don't understand anything of what i say. But i always said we don't care of those epigenetic things, only the body can restore that by itself, no synthetic man made crap will properly restore the balance ever (and especially not long-term). And yes the environment/medium influence gene expression, i said that since a long time ago. And again adding more synthetic nutrients won't help the lymph cleaning this medium in any way.

The body has a balance, you can't add very high amount of articifial isolate without creating more problems.

you said 1. accutane symptoms werent epigenetically based or cured

2. you said deficiency levels go back to normal within a year

provide me a study showing these intra-cellular levels go back to normal after stopping accutane, otherwise i dont want to hear any of your lymph eyeball nonsense

provide me a study showing these intra-cellular levels go back to normal after stopping accutane, otherwise i dont want to hear any of your lymph eyeball nonsense

provide me a study showing these intra-cellular levels go back to normal after stopping accutane, otherwise i dont want to hear any of your lymph eyeball nonsense

anonny even if it is gluccuronidation alone that detoxifies accutane then there is a supplement that supports this pathway and it is called calcium-d-glucarate also this pathway is supported by probiotics. Also methylation plays a major role , the most important actually at detoxification so even if accutane can not be detoxified thorugh methylation then most of the toxins can as glutathione is one of the most important products of methylation and it is the major antioxidant that the body produces.

1. wrong, i said multiple times everything that reach the cellular medium affect gene expression.

2. wrong, i gived multiple explanation for deficiencies, that's just one among many others (and incomplete, i said everything fluctuate inside the body and that high amount of isolates won't restore the balance, as nutrients work in synergy and can compete with others).

I don't care of your studies. And even if there is intra-cellular accutane (it's one of my theory i posted there btw), there is absolutely no link with folate or methylation that detoxify accutane.

I know about glucarate i already talked about it last year.

Toxins are eliminated via the lymphatic system, even if glutathion help neutralize toxicity. The problem isn't accutane anymore, but the devastation/toxicity it caused.
No synthetic supplement will help proper glutathione balance or the lymphatic drainage, i already tried lot of SAMe and glutathione supplement and their precursors.

anonny even if it is gluccuronidation alone that detoxifies accutane then there is a supplement that supports this pathway and it is called calcium-d-glucarate also this pathway is supported by probiotics. Also methylation plays a major role , the most important actually at detoxification so even if accutane can not be detoxified thorugh methylation then most of the toxins can as glutathione is one of the most important products of methylation and it is the major antioxidant that the body produces.

ive already posted a link between glucuronidation and methylation... he doesnt want to acknowledge it.

Well maybe he is correct that glucuronidation is needed to detoxify accutane but that does not mean that he is right in everything else that he said.

Anyway I just want to here recovery stories. Did annonyy recovered from accutane side effects? Did you manage to do it tryingtohelp?

Your dumb link that accutane supposedly deplete b vitamins long term so there is not enough methionine for glucuronidation? If that theory was true, we won't see a decline of accutane in the blood and an elevation of glucuronides excretion, and we will still be able to see accutane in blood years after. And except if i'm wrong, only the liver is capable of high levels of glucuronidation required for accutane, never read that other part of the body was able to do the same (even if the udp-**transferase enzyme is found in some other organs), and even if it was the case, we will see accutane glucuronide month/years after in urine, not the case. If you want to try that theory, just take 1 liters of long-fermented kombucha every day for month, like i "theorized" year ago, it helps a little but of course far from being enough since it doesn't address the whole problem/cause.

Accutane is gone, the problem is the devastation & toxicity/congestion he left behind it.

Well maybe he is correct that glucuronidation is needed to detoxify accutane but that does not mean that he is right in everything else that he said.

Anyway I just want to here recovery stories. Did annonyy recovered from accutane side effects? Did you manage to do it tryingtohelp?

S-adenosylmethionine (SAM), an important physiological agent formed in the body by combining the essential amino acid methionine with adenosyl-triphosphate (ATP) has been shown to both activate several Phase II pathways (including glucuronidation) as well as promote bile flow and relieve cholestatis. {Pizzorno, 157} {Murray, 372}.

<---- man this paragraph reads like it just came out of an accutane cure handbook doesnt it?

one week in...

here is what i suggest:

1. get tested for MTHFR at 23andme.com

1000-2000mcg methyl b12

800-1600 mcg methylfolate

1000-2000MG TMG going higher later

p 5 p active form of b6 (again this might change upon genetic results)

200-400 mg magnesium citrate

small B2

small zinc

Kefir and other fermented probiotics... all this is doing is helping the body naturally absorb the B vitamin, and restoring the gut flora.

stay away from any processed foods with folic acid additive.

any methylation cofactor would help any potential block. taking SAMe direct is not advised...fix the deficiency problem first. unless you have the cofactor problem fixed first, taking SAMe could raise homocysteine later.

the big three being methyl-b12 methylfolate and TMG.

Yea that's why it doesn't work.

Lot of things affect glucuronidation, not only your SAM.

The is no magic solution, what you don't understand, i repeated it hundred of times, health issue = lymph congestion & lack of kidney filtration. First step is the diet. If you want to go rambo detoxification you eat only raw fruits or fast (fast = bad idea if too weak & no filtration) for multiple weeks by doing some break with cooked vegetables, and if you have trouble filtering you have to use some herbs or glandular's. I posted multiple times link about the subject.

Your dumb link that accutane supposedly deplete b vitamins long term so there is not enough methionine for glucuronidation? If that theory was true, we won't see a decline of accutane in the blood and an elevation of glucuronides excretion, and we will still be able to see accutane in blood years after. And except if i'm wrong, only the liver is capable of high levels of glucuronidation required for accutane, never read that other part of the body was able to do the same (even if the udp-**transferase enzyme is found in some other organs), and even if it was the case, we will see accutane glucuronide month/years after in urine, not the case. If you want to try that theory, just take 1 liters of long-fermented kombucha every day for month, like i "theorized" year ago, it helps a little but of course far from being enough since it doesn't address the whole problem/cause.

Accutane is gone, the problem is the devastation & toxicity/congestion he left behind it.

man youre an idiot. you say things and then totally contradict what you say. you yourself said the body will do whatever it can to remain in a homeostasis!!

whatever it cant immediately glucurdinate out, gets stored somewhere obviously. youre not going to see accutane in the blood! thats why these side effects can last decades.

 

Already answered that at least 100 times. The solution imply self responsability & patience, most people are too childish to do that, prefer take a magic pill, so anyway no matter what i say, i believe you will not be interested. No one can help you better than yourself. Just take accutane and you'll come again to cry after the treatment. Can't do more at raising awareness that i already do. You follow the path of those who destroy health to get money or you follow nature/physiology who get real results, your choice now.

Stop trolling and give a real solution. You didn't answer the question directly once. "Self responsibility and patience" doesn't describe anything.

he has to be a paid troll right? its the only thing that makes sense. am i the only one picking up on this? we must be close.

I forgot what i said? Do you know better what i said in my previous 300 posts than me maybe? You seems fairly retarded man.

Yea believe that accutane still here if you want, go chase ghosts little kid x) and get scammed by people who sell petroleum supplement. That folate hippie guy is so funny.

And yes i'm an idiot, trying to talk to some morons who have no more than two neurons capable of communicating with each other.

You are not here to think, to make things go further, you are just here to defend your little child ego. We already know about all the stupid theories you are spamming here for years (which doesn't help/work), you are a little late, sorry.

T R O L L

Lot of things affect glucuronidation, not even your SAM.

this right here is what im talking about. just read his statement above, and try to make any sense of it. you cant.

I feel sorry for you :/ really. I hope you really lied about your age, because if you really are 35+ years old it's really sad.

I meant "not only"*, not "not even", if you had neurons you'll have figured it by yourself.

The thing that makes no sense is that you are both failure but still try to argue (insult) people who succeed and have more knowledge and experience than you. I know it piss you off that i already talked and know about everything you bringed here, it hurt your poor childish ego. You have brought nothing but copying my own word and past theories/message here.

You really have no personality and nothing real/useful/working to argue with except lying, insulting and using my own words, you have no knowledge, you are still at the point i was 5 years ago.

Come back arguing/insulting when you will succeed something with your acne or accutane issue and when you'll have something new to say kid. But i know, you have difficulties arguing without lying, like all fake and weak people. Until then go pollute a forum who suit you better, maybe some schizophrenic one.

ps: i know that you have difficulty to make sense/understand things, it's fairly obvious x)

I really don't care of annoying some people, if truth is a problem for them, not my problem. I'm here to fight for what's true to help some who deserve it, sadly there is some clueless cockroach here who like promoting ignorance and stupidity and preventing other from understanding how things really are, because they are cowards. I don't care of others personal opinion, specially when it's full of bullshit. You don't even realize that it unserve you, you can insult and mock the reality and people who get results as you want, at the end of the day you'll still be struggling, you can't do better with your childish ego game than to ignore and insult what i'm saying (physiology/lymphatic system/medium/detoxification/herbs), because it's the only way to get your health back, and you will be deprived from it doing so.

I don't even know why i tried to help such a pityful low-minded person, trying everything to protect his ego instead of trying to understand things, by lying, insulting, trying to mock physiology and jubilating of his own stupidity and failure. You can try to "mock" (actually you just ridiculize yourself) the lymphatic system & cellular medium (& diet, detoxification, etc..) as long as you want and link studies who never helped anyone here we already linked/tried/know about who just prove there is symptoms, but that doesn't address the cause, you'll be the one who will be forever at the bottom of the pit, and you clearly deserve it.

You have no clue of how the body work, you are an egotic uneducated child. The only thing you have is the MTHFR and synthetic folate supplements etc.. scam theory, which of course we all already know and already tried. I'm way ahead of this crap, i'm cured of my accutane problems which i never saw anyone having worse here, i'm interested by understanding how the body work and the real cause of "diseases" and things that truely work at regenerating a body, we are not playing in the same category, and knowledge + experience level. Stay in your ignorance, stupidity, egotic & your sickness symptomatic world/point of view, you are not in the capacity for understanding how things truely are and the higher levels.

I feel filthy just to have talked to you. And i don't even think that you are here to argue about health, you clearly maked it a personal thing, but you'll have to do better than the pathetic attacks you are trying to do atm. But i understand you, you have no real knowledge, no experience, of course you have to lie and try to mock things you don't have the capacity to understand, it's just sad for you, at least i tried. You are a very low person.
You even create and use multiple account trying to help yourself in your no argument childish uneducated attacks, you are a funny guy.

Anyway i'm not interested at helping you anymore, i've done my responsability, true smart people won't have trouble understanding what's true/real and what's not, and the others will have to deal with their own arrogence, ignorance & bad choices.
Without me i'm afraid that this topic will be re-colonized by failure deceiving morons who like to promote fear-based ignorant symptomatic thinking that never helped anyone but hurted and pushed to suicide many, but.. that's humanity, can't help it. Bye.

Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis.

i am recovering from post accutane problems, i did so by applying tons of grape seed oil (high in linoleic acid) to my upper arms and experienced muscle twitches shortly afterward. since then I've been recovering a little each day, i kid you not, nothing worked for years until i came across this shot in the dark. it took two years for it to come on and it will take two years to go away, I'm hallway through and recovering everyday. good luck to you all, pass this on!

i am recovering from post accutane problems, i did so by applying tons of grape seed oil (high in linoleic acid) to my upper arms and experienced muscle twitches shortly afterward. since then I've been recovering a little each day, i kid you not, nothing worked for years until i came across this shot in the dark. it took two years for it to come on and it will take two years to go away, I'm hallway through and recovering everyday. good luck to you all, pass this on!

what symptoms are you getting better from? what is your protocol? just topically?

symptoms? All. Joint, skin, focus, genitalia, i had em all.

i am recovering from post accutane problems, i did so by applying tons of grape seed oil (high in linoleic acid) to my upper arms (especially triceps where the red bumps were) and experienced muscle twitches shortly afterward. since then I've been recovering a little each day, i kid you not, nothing worked for years until i came up with this shot in the dark. I only had to apply it once (1/4 cup should do), you'll know when your recovering. it took two years for it to come on and it will take two years to go away, I'm hallway through and recovering everyday. good luck to you all. Pass this on!