It help calm because it depress the nervous system but it can be highly dangerous for some people, i know lot of people who had panic attacks for month (me included) after taking pot. There is far more stories of people getting rid of cancer with diet & fast & other detox cure than RSO. I don't even understand how that RSO work, official theory is by telling the mutated cells to self destruct and by stimulating the immune system bit i think it's more about stimulating the nervous system in a good way/dosage (adrenals) to get the kidney filtering lymph again. Cannabis rise dopamine, which is the neurotransmitters more related to detoxification, epinephrine/adrenaline does the opposite (an other reason why meat is toxic, it is full of epinephrine). But by smoking it you'll never have the RSO benefit, the dosage (+ wrong form of THC) are really bad that way and will only depress the nervous system very damagingly, not gently stimulate it in a good way.

Glucuronidation and Cancer:

Jacob Schor, ND FABNO

written in 2003

Glucuronidation is one of the most important Phase II conjugation pathways in the liver for detoxification and excretion of carcinogens, lipid soluble hormones and steroid hormones. The liver, through a series of chemical reactions, attaches glucuronic acid to the target chemical and then excretes this chemical complex in the bile into the intestine. (At this point the story turns into the script of a low grade suspense movie. At the end, when you finally breathe a sigh of relief, the defeated murderer, monster, or whatever suddenly leaps back to life. Once the liver has safely tied up these dangerous chemicals and dumped them into the sewer line, you might think the story was over. Not by a long shot.) Beta-glucuronidase, an enzyme produced by intestinal bacteria, can break the bond between excreted toxin and glucuronic acid. These excreted toxins and hormones that were history, are reactivated, quickly reabsorbed into the body, and are back to no good.

For disease, and especially cancer prevention, one wants low Beta-glucuronidase activity. Beta-glucuronidase levels in the intestine can be measured as part of the evaluation performed in a digestive stool analysis. If these levels are high, it is a prudent idea to lower them.

Beta-glucuronidase can be lowered by establishing healthy bacterial flora in the intestine by eating a diet high in plant foods and supplementing the diet with the friendly bacteria, Lactobacillus acidophilus and Bifodobacterium bifidum. Other dietary factors that dramatically decrease the activity of this enzyme are consumption of onions, garlic, and foods high in glucuronic acid like apples, Brussels sprouts, broccoli, cabbage, lettuce and especially oranges.

Glucuronic acid is available in pill form as Calcium D-glucarate. Calcium D-glucarate indirectly inhibits the beta-glucuronidase enzyme dramatically preventing its ability to reactivate excreted toxins.

Suggested as a possible magic bullet in prevention of breast cancer, especially in women who have already had one occurrence, in contrast to Tamoxifen, Calcium D-glucarate is completely safe and possibly more effective.

Dose: 2,000 mg 2x/day for ER/PR positive.

-Heerdt AS, Young CW, Borgen PO, Calcium clucarate as a chemopreventive agent in breast cancer. Israel Journal of Medical Sciences. 31(2-3): 101-5, 1995.

-Walaszek Z, Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Letters 54(1-2):1-8, 1990

-Abbou-Issa H. Moeschberger M, el-Masry W. Tejwani S. Curley RWJr. Webb TE. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Research. 15(3):905-10, 1995.

-Murray. Breast Cancer: Update on a growing Epidemic Natural Medicine Journal. March 1999. 2(1);1-6

TMG (Trimethylglycine) / Betaine - Reduces Bilirubin, Estrogen, Increases Bile Transport, Enzyme Support, Mood

Theres your accutane/gilberts syndrome/high bilirubin cholestasis/b12 folate TMG /gluccurondination links

what is kombucha high in ? b vitamins

whats kefir high in? b vitamins

what has accutane beeen clinically proven to deplete? folate and B12

what do the liver and kidneys need more of to detoxify b vitamins

Will you stop this meaningless brain masturbation? the body doesn't need anything to be added more than physiological foods, it need things to be eliminated & balance restored. Taking isolate won't restore the balance or drain lymph, they will create imbalancies and will be excreted by the kidneys, your money will go directly in the toilet. And i repeat, we all already tried those false theory here.

Every nutrients, vitamins & minerals are required for every action inside the body, the body work as a whole, everything connected, don't try to find connection to some vitamins to explain something, all of them will be related to any subject you are looking into.

Stop this ignorant everything is caused by deficiency thinking, it will lead you nowhere. Except if you are fasting for month and lost lot of weight, maybe you can have some slight deficiencies (and even in that case people doesn't show deficiencies in blood tests cause the body constantly adapt itself). The only way to get deficiencies is to eat for year the same non-physiological food (ex only meat, only maize, ..). Blood tests are meaningless, they doesn't show if the cells properly absorbed the nutrients. And you can even have low nutrients in the blood because the cells absorbed more than usual nutrients that day/period, everything fluctuate inside the body, it's a living thing. There is also reserve of nutrients in the body.

Will you stop this meaningless brain masturbation? the body doesn't need anything to be added more than physiological foods, it need things to be eliminated & balance restored. Taking isolate won't restore the balance or drain lymph, they will create imbalancies and will be excreted by the kidneys, your money will go directly in the toilet. And i repeat, we all already tried those false theory here.

Every nutrients, vitamins & minerals are required for every action inside the body, the body work as a whole, everything connected, don't try to find connection to some vitamins to explain something, all of them will be related to any subject you are looking into.

Stop this ignorant everything is caused by deficiency thinking, it will lead you nowhere. Except if you are fasting for month and lost lot of weight, maybe you can have some slight deficiencies (and even in that case people doesn't show deficiencies in blood tests cause the body constantly adapt itself). The only way to get deficiencies is to eat for year the same non-physiological food (ex only meat, only maize, ..). Blood tests are meaningless, they doesn't show if the cells properly absorbed the nutrients. And you can even have low nutrients in the blood because the cells absorbed more than usual nutrients that day/period, everything fluctuate inside the body, it's a living thing. There is also reserve of nutrients in the body.

or if you take a drug that has been PROVEN to cause said deficiency.

shut up about your extremely vague lymphatic system mumbo jumbo I R I D O LO G Y nonsense. Id be willing to bet you havent fixed one of your symptoms. If i had fixed myself, the VERY LAST place i would be is daily trolling an accutane msg board LOL!

are you sure youre not Robert Morse? QUACK QUACK QUACK

"hey you have a hole in the right corner of your eye! you must drain your lymph!!"

how do you drain your lymph?

" i told you to drain your lymph stupid!"

So if iridology is nonsense (according to your extremely limited knowledge of physiology) sudently the lymphatic system doesn't exist?

So why it doesn't work to take the isolate of active b12 folate b2 b3 b6 etc..?

You should stop act like a child and use your neurons a little, you'll find that taking isolate create antagonism to other nutrients & body function, creating other problems, you seems to know only little about how the body work but still you try to find pseudo-theories that are proven not working and damaging. The body is only adapted to nutrients & their ratio from fruits & vegetables, not adapted to man-made dirt one.

So if iridology is nonsense (according to your extremely limited knowledge of physiology) sudently the lymphatic system doesn't exist?

So why it doesn't work to take the isolate of active b12 folate b2 b3 b6 etc..?

You should stop act like a child and use your neurons a little, you'll find that taking isolate create antagonism to other nutrients & body function, creating other problems, you seems to know only little about how the body work but still you try to find pseudo-theories that are proven not working and damaging.

So why it doesn't work to take the isolate of active b12 folate b2 b3 b6 etc..? is that all you took? what dosage, for how long. did you take the rest of the co-factors? were you missing one of the links in the methylation cycle? did you have any bloodwork done? were you tested for the MTHFR defect? did you incorporate TMG magnesium , probiotics at the same time.

and to say that something isnt working... guess what , if your lymph system stopped working, you would be D E A D. so there goes that theory.

keep trying to drain that lymph through your eyeball annoying ... its a noble profession.

i stopped listening to you at I R I D O L O G Y.

I'm just here to tell people what's true and what's not, and how the body work, from what i experienced and learnd, since i already tried all the stupidity you are spamming like it's a revelation we never heard about before.

You don't want to drain your lymph through your eyeball, you have kidneys for that. You clearly have no clue of how the body work.

I never talked about iridology, you seems to try hard find any bad excuse for your own childish ego.

Who said the lymphatic system stop working? it simply get congested, what do you think comes out when you are sick, what get swollen, what are pimples?. And why do you think people taking accutane get swollen spleen which is the lymphatic system.
And yes, if the lymphatic system become completely blocked, you die within 2-3 weeks. Accutane is a lymph blocker & destroyer (mucosa, skin and other tissue accutane destroy are a part of it or drain with).

You have no clue about what you are trying to criticize, but you have no clue about anything you are saying since the beginning so.. what to expect.

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011

http://www.ncbi.nlm.nih.gov/pubmed/25266008

 

what has accutane beeen clinically proven to deplete? folate and B12

That's interesting to note, do you have a link to the study you're referring to there?

Also noticed you've mentioned you suspect the methylation cycle has been impaired by this drug. A number of others appear to have come to this conclusion (there is a thread on it over on the ATM accutane suffers sub-forum) and the theory behind in appears sound, but I don't know anyone who's has success in following a 'methylation support' protocol.

I tried following this 'methylation process restart protocol' for a month last year, but didn't notice anything;

• Methylcobalamin 1 mg sublingually
• Methyltetrahydrofolate 800mcg (ActiFolate)
• Pyridoxal-5-phosphate 100mgs (50mgs twice daily)
• Glutathione 250mgs daily
• Phosphatidyl Serine 200mgs (100mgs twice daily) - BioCare

The only things that I've taken that have resulted in noticeable improvements in my sides are (and I've taken probably 50-60 different sups);

- gingko & ginseng (these have helped my ED - stronger erections, and also before taking these I was rarely getting morning boners, but these brought them back despite the fact I stopped taking both months back, the effects have remained. When I first started taking them I found if I stopped the morning boners went away again after 2-3 days, but if I started taking again, they returned 1-2 days later. Like I said though, stopped both now and improvement remains)

- green tea - (but only in natural form, dragon well leaves). This resulted in even stronger erections. Apparently an AR5 inhibitor, so I've reduced how much I have, but still have probably 1 cup per day. Also improved libido.

- weed - vaped or in rso form, not smoked. This has been the most effective so far - similar effect to the green tea, but also results in improved orgasm, however so far that is really on the case when actually stoned. Improves libido more than the green tea did.

Those all affect adrenals, that's why they are effective ; ) you can try the glandular i linked last page and it will be even more effective than those.

Anonyy's right they are all adrenal herbs except cannabis, but Gingko and ginseng might also be effective because they increase circulation which allows more blood into the penis, hence better erections.

Those all affect adrenals, that's why they are effective ; ) you can try the glandular i linked last page and it will be even more effective than those.

Bit of googling, and you're actually right about that...

- gingko - "Ginseng increases the bodys ability to handle stress, reduces fatigue and naturally supports healthy adrenal function and hormone levels"

http://naturallysavvy.com/restore/top-5-herbs-for-fighting-fatigue

- green tea - "An adaptogen in its own right, green tea supports the adrenal glands to help reduce stress"

http://www.healthysmoothiehq.com/adrenal-support-smoothie

- ginseng - "Ginko Biloba has been studied to protect the adrenal glands, the brain and the liver from damaging free radicals"

http://naturallysavvy.com/restore/top-5-herbs-for-fighting-fatigue

- weed - "drugs, including marijuana, are stimulating to the Adrenals because they create a toxic reaction inside the Liver which draws its energy from the Adrenals" (not especially a positive..)

http://www.naturalhealthprotocol.com/blog/how-does-marijuana-affect-the-brain-and-adrenal-gland

Might phase some other herbs which are supposed to support adrenals into my routine, seeing as I've got plenty sitting around, so I might start taking nettle root, maca, licorice root, ashwaganda, gingko and ginger caps in addition to my current multi-vit & cod liver oil capsule and see if I notice anything!

Another one to add could be l arginine. I started taking that because it improves blood flow and read how it supports the adrenals

On 10/9/2014 at 2:49 AM, tanedout said:

On 10/8/2014 at 10:48 PM, tryingtohelp2014 said:

what has accutane beeen clinically proven to deplete? folate and B12

That's interesting to note, do you have a link to the study you're referring to there?

Also noticed you've mentioned you suspect the methylation cycle has been impaired by this drug. A number of others appear to have come to this conclusion (there is a thread on it over on the ATM accutane suffers sub-forum) and the theory behind in appears sound, but I don't know anyone who's has success in following a 'methylation support' protocol.

I tried following this 'methylation process restart protocol' for a month last year, but didn't notice anything;

• Methylcobalamin 1 mg sublingually
• Methyltetrahydrofolate 800mcg (ActiFolate)
• Pyridoxal-5-phosphate 100mgs (50mgs twice daily)
• Glutathione 250mgs daily
• Phosphatidyl Serine 200mgs (100mgs twice daily) - BioCare

The only things that I've taken that have resulted in noticeable improvements in my sides are (and I've taken probably 50-60 different sups);

- gingko & ginseng (these have helped my ED - stronger erections, and also before taking these I was rarely getting morning boners, but these brought them back despite the fact I stopped taking both months back, the effects have remained. When I first started taking them I found if I stopped the morning boners went away again after 2-3 days, but if I started taking again, they returned 1-2 days later. Like I said though, stopped both now and improvement remains)

- green tea - (but only in natural form, dragon well leaves). This resulted in even stronger erections. Apparently an AR5 inhibitor, so I've reduced how much I have, but still have probably 1 cup per day. Also improved libido.

- weed - vaped or in rso form, not smoked. This has been the most effective so far - similar effect to the green tea, but also results in improved orgasm, however so far that is really on the case when actually stoned. Improves libido more than the green tea did.

Unlike the eyeball lymph charlatan guy.... i have pubmed studies backing up what i say. i am trying to separate FACT from nonsense. As far as you trying to remethylate. maybe increase the dosage, increase the number of cofactors taken including Mag, increase the actual methyl donors (TMG), or even add SAM-E directly, increase the time taking it? I think people give up way too easy, including myself. But when i see a drug specifically drain your body of a specific nutrient, and studies were done showing this, you should take note. Remember, you needed 4 months of accutane for it to work.

I also think Accutane ruins the gut flora and the gut lining by simply not allowing the cells to replicate fast enough, and over time, you lose even more ability to absorb what you need...especially the B12. This is where probiotics come into play. Probiotics would also be tied to the Calcium D-Glucarate and the bacteria/enzyme known for unbinding the toxin and sending it back into the bloodstream.

Accutane didnt drain your body of RSO or weed vapors or ginko/green tea. those would just treat the symptoms, not the problem. I believe the continued Accutane side effects are epigenetic (this would also explain complaints from people being on the drug for as little as a week, and suffering the same side effects years later). From curezone:

"What is unusual about the retinoic acid (or Accutane) is that it affects gene expression, by biochemical manipulation. Few supplements affect gene expressions, carnosine, trimethylglycine, accutane, hydrazine, B12. folic acid, the whole study is related to epigenetics and that study has a very limited range of supplements you can use at the moment and somehow plays and important role in evolution. I know that because of my experiments I conduct with plants as the initial study.

Vitamin K2 m4 and vitamin D3 also affects gene expression so they would counter the Accutane too, but vitamin K2 m4 must be taken first before the vitamin D3 or taken at the same time, but NOT ALONE, or it causes arteriosclerosis in some cases when combined with high cholesterol or stroke. "

[Edited link out]

Effects of oral isotretinoin on serum folic acid levels.

Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study.

They are also all 5AR inhibitors too. Bit depressing that seemingly the only things that provide relief could potentially be a double edged sword.
I notice after every period of brief fasting or raw veganism and I switch back to a paleo diet leads to a sudden rush of feeling (mildly) closer to sexually normal (bar the anaesthesia). I suspect this could be that both those things (vegan, fasting) would be anti-androgenic and thus following a higher protein/calorie diet leads to a rush of androgenic hormones before settling back to normal.

Speaking of epigenetics; Crank, I thought your profile pic was some strange methylated nucleotide base like thymine bonded with cytosine and wondered why it wasn't attached to a sugar.

...Caffeine, which resembles methylated adenosine. Nice! Drink it up.

Very very cool video about epigenetics and methylation ... starting at min 12. we have to change the medium.

Now after watching this.... does Accutane change the medium by altering the methylation, by way of depleting the body of folic acid, B12, trimethylglycine?! Does it change how our body is reading our DNA?!!!

the blood is the culture medium!

This guy is so dumb, says lymph eyeballs blabla doesn't exist and now telling we have to change the medium, what do you think the medium is and what do you think i'm talking about since the beginning. All cells bathes in the interstitial fluid, which is lymph.

The lymph is the culturing medium.

I already quoted on this forum last year this Lipton guy saying that precise thing, that the medium is everything (no like we didn't knew it already). Dr Morse among with others good doctors are saying the same thing ofc.

Charlatan are the one telling you that you have to buy man-made synthetic isolates supplement or drugs to get well and that say diet isn't related in any way to health issue.
We all already tried those supplement you are talking about and it doesn't work cause it's obv stupid thinking. And those synthetic crap will be "effective" (at causing imbalancies) only while you take them, if you stop them you won't feel the stimulation and any effect from them anymore. The body need nutrients from fruits & vegetables, in the proper ratio we had since thousand and thousand of years, we are not made to eat synthetic dirt extracted artificially from petroleum or refined rocks (or other crap).

Your studies (that i already know about and linked at some point, before you came here) means nothing, they just prove that accutane affect everything inside the body but we already know that, we don't need to know what the symptoms are, since there is only one solution to fix the cause and get cells healthy again, = cleansing the lymph to restore a clean alcaline (toxins free) medium. Focusing on the symptoms to treat the cause is retarded medical doctor's thinking.

And those studies tested the blood of people right after taking accutane for one month, of course that cells use more of some nutrients while it receive chemo and get damaged, it's temporary, it doesn't means you have deficiency, your cells absorb & use more of those nutrients and you see lower levels in blood. Check the blood one year after accutane and not while or right after you took it, you will still feel bad but you won't see deficiencies, and even if you have some, taking synthetic isolate will only create even more imbalancies & deficiencies (and it doesn't work we all tried that), only way to have deficiencies is to have a really really bad non-physiological diet & under-eat. And you can have no deficiencies in the blood but deficiencies in the cells when you have clogged medium (lymph) and in that case it's not a solution to take incredibly high amount of isolates to hope some will reach the cells, and if it does it will prevent other nutrients from reaching them & will create even more clogging & deficiencies.

Health problems isn't deficiencies, it's lymph congestion which create a toxic clogged cells medium which cause cells to get self-poisoned and not being able to receive nutrients.

And about your K2, again, i already linked it here among with fermented skate liver oil theory of W.A Price. The problem is the toxicity, which deplete calcium, not lack of anything. It's linked to the parathyroid too.

You have no clue about physiology, stop promoting ignorance and stupidity, if not for you, for others. And now i'll stop answering you, you are a stupid egotic child and you are not worth it.

Cannabis affect adrenals, that's his main effect.

Meat is known to enhance libido as it's an irritant for the sex organs, and because it contain tons of adrenalin (adrenals again) & hormones.

medium=blood ... he says this specifically.

you really are an idiot. First you say to take b12. then you say you cant take isolates. then you say pubmed studies are useless. Then you say blood tests are useless....then you say if you check the nutritional status (by a blood test,) its back to normal in a year. wait, what????? which is it?

Skate liver oil... WHY ON EARTH WOULD YOU EVEN CONSIDER TAKING THIS? now thats one thing i wouldnt take. IT IS LOADED WITH VITAMIN A!!!! geeez while youre at it, why not eat a polar bear liver and really kill yourself. weston a price didnt have the benefit of having vitamin k2 in a pill... it didnt even have a name when his theories came out... it was called X factor. what study shows vitamin K2-M4 becomes toxic? i cannot find ONE reference to this in any study ANYWHERE. vitamin k2-M4 has a half life of one day, is not stored anywhere, and up to 45 MG!s! have been taken with no adverse effects. thanks, but try again.

and by the way...in the second folic acid/b12 study, this was after 4 months of use, and it remained depleted post treatment. reading is a skill. wrong again. and where is your confirmation that the depleted levels magically rise after one year post treatment? oh i know, its the "i'm pulling this out of my ass study by anoyy"

You sir, are a walking talking living contradiction. a guy with a PHD is a joke, thats been teaching REAL classes for 20 years... but yet your eyeball iridology guy with a ND (which anyone can get) is the real deal. LOL

i am crushing you in every argument....but keep going.

Im beginning to think you were sent here by Roche as a troll? to throw people off?

annoy = "theres no trick to cleaning the lymph, its just a simple trick"

Yep you are clearly highly stupid, you didn't read/understand a quart of what i said since the last 4 page. Read what i said about vitamin A & B12 there instead of lying. B12 is a controversial since it came from bacteria + cobalt in the soil that we highly destroyed past 50years, plus the use of pesticides & antibiotics. But until we know more, we can take B12 once/twice per month and not more because it appears to be toxic for the parathyroid.

I already answered about deficiencies and their multiple meanings and why supplements are crap, and again, if that was so easy as taking supplement, why it doesn't work? i don't even understand how someone can be that stupid, relentlessly pushing the same false non-working and stupid thing that we already tried. Tell me one person who succeed at getting rid of accutane problems, or cancer & other signifiant issue on vitamin supplement, you are so funny. And why is it so hard for you to understand that the body is adapted to absorb the nutrients & their complex with their proper ratio from fruits & vegetables, you are so naive that you are being scammed by companies telling you that you need to buy pretroleum or refined rock extracted powdered isolated nutrients.

You are clearly a clueless child who doesn't understand anything. You are trying patheticly to refute physiology, the lymphatic system, the two side of chemistry, toxicity, detoxification (i only talk about those here) & a doctor who have far more experience, success & knowledge than you. Repeating "eyeball" like it will make the lymphatic system & the interstitial lymphatic fluid/medium non-existant, don't get what you are trying to do there, maybe prove that you are obviously dumb and a child.

You are a failure, you succeed nothing, you are still whining like a baby about the side effects while refuting the truth, still trying to find answers in symptomatic symptoms on meaningless, not helping studies we all already know of.

And we don't care about your ND, PHD blabla, those all means nothing as long as you don't understand physiology and the root cause of "diseases" which are in the lymphatic system & the cellular medium which is lymphatic too. Most people with certification are simply drug dealers, only some rare are really good doctors. And you know that people who created accutane and those who gived it to you had some PHD blabla right? you use false argument when it arrange you. You want some studies which "proove" accutane is safe, you who like so much studies?

I quoted this Lipton guy, it proove that he's not a joke, he understood the most important thing, the environment/medium which is lymph. Again a pityful attempt to protect your little child ego with lies. You have no other way to use lies, you are too stupid to bring something real, you make me laugh trying to say you are 35+ years old when you clearly have no more than 16. You even try to use my own word now, the medium (which is lymph), pretending i said otherwise. You don't know yourself what you are saying/talking about, stop this nonsense.

You are brain damaged man, you are talking alone, where did i said that vitamin K2-M4 is toxic? and how can you compare 200mg of skate liver oil and eating polar bear liver? And yea i know that you prefer taking man made synthetic crap supplement, it suit you well.

The real deal is the one who is healing others and having results, but apparently you have trouble with true real things, better take pretroleum supplement that doesn't work to get better ofc.

You have no argument and you are a failure. Continue to spit on someone who helped more than 100k people (without counting those online) while you didn't even succeed at helping yourself, you are the most pityful and stupid person i have ever encountered.
Actually your only argument since the beginning is "eyeball" which no one except you talked about, but what to expect more from a failure clueless kid who like spitting on people who succeed. DrMorse worked inside the official medicine for years and for a time at his beginnings he was an urgentist, saved a lot of people there too, and now he's sharing awareness and knowledge to all, and you, what are you? how much people did you helped? you are so ridiculous.

Continue to believe in a magic pill who will save you, you can try to write a letter to santa supplement department for christmas.

No i'm not here by roche, i'm trying here to make people understand you won't find answers from the same people or their way of thinking that poisoned you (symptomatic thinking, studies who focus on those symptoms, everything-deficiencies or genetic theories, drugs, supplement, ..., everything that make you to depend & be at the mercy of them/other false beliefs). Only humans stupid enough to think they know better than nature and can do better with their toxic drugs & supplements while ignoring his basic physiology. But of course you are too stupid to realize it and prefer insult, lie and mock, that's what happen when a low-minded person encounter an information/reality greater/beyond his limited capacity.
And you why are you here, except promoting stupidity and ignorance? if you came here thinking you found a revelation in methylB12, methylfolate & P-5-P supplement you are mistaken.

A deficiency of vitamin b12 or folate doesn't cause a reaction to eating foods with any retinol in it, nor does a slow methylation pathway cause aching creaking joints, or exfoliative cheilitis of the lips that crack and bleed at night without vaseline. What we're talking about here is a condition of toxicity not deficiency.

Taking B12 or folate is not going to suddenly awaken the liver into purging the toxicity. Nor is taking D3 or K2 going to do anything to the side effects in the short or long term. What Anonyy's talking about is terrain modification of the body, what your talking about is supplement cure alls and you can ask virtually any of us what's the net result of all the supplements we've taken and it'll probably be close to zero. I've taken D3 for nearly 2 years, i've taken vitamin K2 in the form you talk about, i've taken b complex and isolated b12 in really high amounts, did any of them work? no. Did they cost a lot of money? yes.

Unless there is a study on 100 people with post accutane side effects ranging from mild to severe in a double blind placebo setting with a cure then i'm not interested because they aren't relevant to us. You have to understand that we are the real 'blank generation' just like Richard Hell sang about. There is no foundation (like ALS) set up in our honour researching a cure for us, you either turn your back on the allopathic community and go it blind or go back to them and get the same results you've always gotten.

A deficiency of vitamin b12 or folate doesn't cause a reaction to eating foods with any retinol in it, nor does a slow methylation pathway cause aching creaking joints, or exfoliative cheilitis of the lips that crack and bleed at night without vaseline. What we're talking about here is a condition of toxicity not deficiency.

Taking B12 or folate is not going to suddenly awaken the liver into purging the toxicity. Nor is taking D3 or K2 going to do anything to the side effects in the short or long term. What Anonyy's talking about is terrain modification of the body, what your talking about is supplement cure alls and you can ask virtually any of us what's the net result of all the supplements we've taken and it'll probably be close to zero. I've taken D3 for nearly 2 years, i've taken vitamin K2 in the form you talk about, i've taken b complex and isolated b12 in really high amounts, did any of them work? no. Did they cost a lot of money? yes.

Unless there is a study on 100 people with post accutane side effects ranging from mild to severe in a double blind placebo setting with a cure then i'm not interested because they aren't relevant to us. You have to understand that we are the real 'blank generation' just like Richard Hell sang about. There is no foundation (like ALS) set up in our honour researching a cure for us, you either turn your back on the allopathic community and go it blind or go back to them and get the same results you've always gotten.

I swear, sometimes i think im speaking a different language. Chico, you really need to research the MTHFR defect and detoxification. And im assuming your Mexican? Hispanics have the highest percentage of this known defect in the world. you should have yours checked at 23andme. Want to know why you might have high bilirubin??? It could be from an Accutane induced b12/methylfolate deficiency causing hemolysis. no matter how many greens you eat, you might be 70% compromised and will never get enough without supplementation... period.

and yes, for some people it is that simple. what exactly do you think im talking about with b12 and L-folate (not folic acid)? IM TALKING ABOUT DETOXIFICATION... you know.... one of the most important ways your body detoxifies... the methylation cycle???? there have been numerous reports on vitamin b12 and folate decreasing joint pain from MTHFR patients....along with numerous other benefits. Of course taking vitamin b12 and folate wont purge the liver immediately... it takes TIME!!! along with other methylation co factors. i think TMG trimethylglycine , the actual methyl donor,(needed for joint and cartilage health, also treats fatty liver AND HIGH bilirubin) is way overlooked here. in the old days they used bone broth soup for the glycine.

as far as vitamin D and K2.... one, on a superficial level, they compete with vitamin A for absorbtion and storage. two, they are also epigenetic vitamins, one of the few, just like accutane., three retinoic acid has been proven to alter a vitamin K enzyme MGP(think calcium deposits and sore joints, your body literally turns into a coral.) it seems i can post study after study... but that doesnt matter anymore.

what dosage?

for how long?

did you have any bloodwork done pre or post?

what other methylation cofactors did you take?

i dont see where you said your took methylfolate (b12 should never be taken alone)

bcomplex could be very bad if it has the wrong folic acid included.

did you take TMG?

there are other variables for sure.... i think people have latched on to bits and pieces, but not the whole thing. Unless youve tried them all, saying they dont work is wrong....you tried one specific way.

an analogy would be.... youre giving your car gas, but no oil....oil, but no spark..... spark, but no air.... then come on here and say , "see gas has nothing to do with my car not starting...i filled it to the top!" you need the entire cycle for it to run, just like your body. miss any one of these things, and it wont start. if this was first level thinking type of stuff, this wouldve been solved years and years ago.

but keep trying to drain that lymph by eating right....has done shit for you in how many years?!

Im done replying ... i will be back to post my one month results and protocol. anecdotally: its only been a little over a week since ive started, but the white of my eyes already seem noticeably more white, also noticed by family members. not terribly excited, as this has been reported to happen with TMG. i would say a 25% increase in energy...i attribute this mainly to the b12.

1000-2000mcg methyl b-12 sublingual

800-1600 mcg methylfolate sublingual (some studies say way higher...think deplin)

1000-1500mg TMG divided doses (some studies say up to 3000mg before benefits) will start slow

25 mg p5p

200 mg mag citrate

200 mg d-glucarate

Kefir (high in b complex)

probiotics

As long as you will think the body as something defective that need supplements and drugs to be altered in the way you want to (and temporarly only while you take them), you will struggle.

Fixing the medium / cleansing the lymph take time when you are really weak (nervously / adrenals) but this is the only way, you can't regenerate anything in a clogged medium full of cellular waste & toxins (which are acidic), no supplement will help eliminate those except herbal one. And yes it can take years and it take self responsability, that's why people prefer to find answers into genetic & deficiency theories by looking for a magic pill, those theories are partly true but again you can't restore the cells or their genetic expression in a toxic medium, and you can't fix malabsorption or force nutrients reaching the cells (which are in a clogged medium) by taking mega high dosage of synthetic isolated nutrients, it will only create more problems and imbalancies/deficiencies.