I know, that's why in that theory you should avoid any drugs (& others things) that use the same enzymes, pepper (poivre), grapefruits, coffee, .. Accutane use UDP-glucuronosyltransferase too. And about the cytochrome i believe it's more the P450 3A4 if i remember.

Here are some of the studies who look at the temporary symptoms/effects (useless so) i noted in the past if that interest you (last paragraph is one of my previous theories & post on this forum):

Glucuronidation is PHASE 2 ...

You have to fix the PHASE 1 first to even get to Phase2? and thats the P450 CYP26

Look at the diagram and what nutrients are needed for Phase 1

[Edited link out]

best explanation about whats needed and why some are affected more than others. it starts in the liver.

[Edited link out]

Glucuronidation

Glucuronidation, the combining of glucuronic acid with toxins, in Phase II can be reversed by Beta glucuronidase enzymes produced by pathological bacteria and cause toxins to be reabsorbed increasing toxicity. Many of the commonly prescribed drugs are detoxified through this pathway. It also helps to detoxify aspirin, menthol, vanillin (synthetic vanilla), food additives such as benzoates, and some hormones. Calcium d-glucurate, a natural ingredient found in certain vegetables and fruits can inhibit beta glucuronidase activity resulting in increased elimination of toxins.

Nutrients Needed by Phase II Detoxification Enzymes

Glucuronidation: Glucuronic acid, Magnesium

Maybe this is why ive heard reports of accutane victims going on high dose MG?

I said accutane use also UDP-glucuronosyltransferase, i don't see where i said anything about phase 1 or 2, i also talked about P450 3A4, 1A1 & 1A2.
I had some pdf about phase 1 & 2 and the nutriments too i'll try to find them. But you don't need isolates, they won't help, you'll create more problems with them.

edit: found some of them:[Edited link out] [Edited link out](looks like yours actually, both contain lot of bs about eating meats & high protein diet, that's why i removed them from my pc). Where you find that screencast picture, i remember seing it in a pdf too (a good one, not like those), interesting that they included flavonoids.

On 10/5/2014 at 4:55 AM, anonyy said:

I said accutane use also UDP-glucuronosyltransferase, i don't see where i said anything about phase 1 or 2, i also talked about P450 3A4 & 1A2.

I had some pdf about phase 1 & 2 and the nutriments too i'll try to find them. But you don't need isolates, they won't help, you'll create more problems with them.

edit: found some of them: [Edited link out]&[Edited link out](looks like yours actually, both contain lot of bs, that's why i removed them from my pc)

its funny, i have a way elevated level of bilirubin and the doctor would always say... not to worry, its gilberts and harmless! I never had a high bilirubin test before taking this drug!

Glucuronidation, the combining of glucuronic acid with toxins, requires the enzyme UDP-glucuronyl transferase (UDPGT). Many of the commonly prescribed drugs are detoxified through this pathway. It also helps to detoxify aspirin, menthol, vanillin (synthetic vanilla), food additives such as benzoates, and some hormones. Glucuronidation appears to work well, except for those with Gilbert's syndrome--a relatively common syndrome characterized by a chronically elevated serum bilirubin level (1.2-3.0 mg/dl). Previously considered rare, this disorder is now known to affect as much as 5% of the general population. The condition is usually without serious symptoms, although some patients do complain about loss of appetite, malaise, and fatigue (typical symptoms of impaired liver function). The main way this condition is recognized is by a slight yellowish tinge to the skin and white of the eye due to inadequate metabolism of bilirubin, a breakdown product of hemoglobin. The activity of UDPGT is increased by foods rich in the monoterpene limonene (citris peel, dill weed oil, and caraway oil). Methionine, administered as SAM, has been shown to be quite beneficial in treating Gilbert's syndrome

Accutane --> depletion of B "isolates"---> impaired Methionine production via impaired methylation

Methionine--->SAM ----> treating Gilberts!

Yea i have conjugated bilirubin elevated too. But this only mean lymph & duct congestion in the liver (& other areas), don't fall into symptomatic thinking focusing on the symptoms and never the cause, disease are an illusion, they are just obstruction.

There is no isolates inside the body, everything work balanced as a whole. I tried to suppement isolates & B multivitamin, never helped anything and actually make me worse. They aren't real vitamin complex like found in fruits & vegetable, they are unusable isolate dead dirt.

And now that i think about it, for those with pseudotumor cerebri, you have to drain the lymph from the head area of course but it can be also excess sodium (experienced it), after accutane you have impaired adrenal & kidney function, you can't tolerate high sodium intake like before. Most people consume more than 5gr of sodium per day but we should not go beyond 1gr (even stupid paleo advocate books acknowledge that our ancestor had a 15:1 potassium:sodium ratio), you can damage your brain (& kidneys, etc..) taking too much sodium.

Anonyy. You make too much sense sometimes.

The conversation about CYP26 brings up a good point. P450 enzymes should be adequate for "deactivating" any metabolites of isotretinoin except possibly the resulting 4-oxo retinoids, which are relatively inactive. Glucoronidation, even with severely impaired glycosidic enzymes, will have eliminated any excess metabolizes after years of being off of the drug.

I'm just a messenger. Just here to share what i learnd, i don't believe anyone had more severe side effects as me, or tried everything i tried to get well. If you want to learn health, not disease-symptoms thinking, most experienced person is Robert Morse*, no one as greater comprehension & results as him. Anyone who pretend being a doctor/healer which ignore the lymphatic system (the major fluid of the body, 3 times bigger than blood) & detoxification is a quack. If some still want to believe in fantasies, enjoy the results of that. I've done my responsability, i'll stop there. Truth needs no defending, it will defend itself.

[Edited link out]
[Edited link out]
[Edited link out]
www.youtube.com/watch?v=FKr4YwGxG3w

[Edited link out]

On 10/5/2014 at 8:49 AM, anonyy said:

I'm just a messenger. Just here to share what i learnd, i don't believe anyone had more severe side effects as me, or tried everything i tried to get well. If you want to learn health, not disease-symptoms thinking, most experienced person is Robert Morse*, no one as greater comprehension & results as him. Anyone who pretend being a doctor/healer which ignore the lymphatic system (the major fluid of the body, 3 times bigger than blood) & detoxification is a quack. If some still want to believe in fantasies, enjoy the results of that. I've done my responsability, i'll stop there. Truth needs no defending, it will defend itself.

*[Edited link out]

[Edited link out]

[Edited link out]

[Edited link out]

[Edited link out]

LOL morse looks like the definition of a quack.

1. ND

2. Believes in Iridology!

Yep, thousand and thousand people he saved will certainly agree with you. You are a child, you'll have to grow up if you want to find health again. Bye now, don't talk to me anymore i have nothing else to say to stupid people.

Yep, thousand and thousand people he saved will certainly agree with you. You are a child, you'll have to grow up if you want to find health again. Bye now, don't talk to me anymore i have nothing else to say to stupid people.

1000s and 1000s and he has 400 twitter followers.. yep, hes big-time! Iridology LOL look, your eyes have a hole in them...youre toxic! LMAO

Yes the lymphatic system & toxicity/acidosis doesn't exist because there is iridology that you can't understand. Bye man, you are a genius. Enjoy your health issues.

Hi guys,

It's been years since I posted here but I was brought back because I recently received an email that someone quoted me. I can't believe this topic still exists (actually I can since accutane is a horrible drug).

I felt obligated to inform everyone here that I am pretty much cured and 100% back to the person I was prior accutane. Long story short, I suffered really bad digestive issues from a second course of accutane which led to a myriad of additional problems. I went through a couple years of terrible pain, thinking that my body would never be the same. I was a wreck, and was very ill. Everyone told me that I looked terrible.

But good news - I found the cure to digestive ailments. I started making homemade kefir and within a week I felt better. Now it's been almost a year and I can say that I've never felt better. A cup of homemade kefir has about 2.5 trillion probiotics. Good luck finding that amount in supplement form. BTW, I tried about every probiotic supplement, and none compare to kefir. Not. Even. Close. Homemade kefir is made from kefir grains which are growing bacteria. You feed them milk everyday, they give you a tasty drink.

Overall, my diet is pretty clean nowadays. No gluten, no gmos, mostly paleo, except that I eat lots of dairy. Plenty of organic foods. I have no issue with vitamin A anymore. But none of that even matters compared to the difference homemade kefir made in my life. Store bought kefir is alright, but it's not "real" kefir, but rather, a probiotic drink. Make it at home, you won't regret it. It will heal your body.

In terms of further detox of accutane, saunas are great too.

Also, good news for the guys who have lost hair after accutane, I found another fix. Please check out this thread/forum:

[Removed]

Long story short, MPB is an inflammation process that involves calcification of the scalp. There's a lot of disagreement in that forum topic, but ignore the haters, this method absolutely works. But it will take up to a year to regrow. Be patient.

Sorry if I repeated anything that's already been said here, I have not read any posts before writing this.

Good luck,

rew

On 10/5/2014 at 9:15 AM, rewopwspe said:

Hi guys,

It's been years since I posted here but I was brought back because I recently received an email that someone quoted me. I can't believe this topic still exists (actually I can since accutane is a horrible drug).

I felt obligated to inform everyone here that I am pretty much cured and 100% back to the person I was prior accutane. Long story short, I suffered really bad digestive issues from a second course of accutane which led to a myriad of additional problems. I went through a couple years of terrible pain, thinking that my body would never be the same. I was a wreck, and was very ill. Everyone told me that I looked terrible.

But good news - I found the cure to digestive ailments. I started making homemade kefir and within a week I felt better. Now it's been almost a year and I can say that I've never felt better. A cup of homemade kefir has about 2.5 trillion probiotics. Good luck finding that amount in supplement form. BTW, I tried about every probiotic supplement, and none compare to kefir. Not. Even. Close. Homemade kefir is made from kefir grains which are growing bacteria. You feed them milk everyday, they give you a tasty drink.

Overall, my diet is pretty clean nowadays. No gluten, no gmos, mostly paleo, except that I eat lots of dairy. Plenty of organic foods. But none of that even matters compared to the difference homemade kefir made in my life. Store bought kefir is alright, but it's not "real" kefir, but rather, a probiotic drink. Make it at home, you won't regret it. It will heal your body.

Also, good news for the guys who have lost hair after accutane, I found another fix. Please check out this thread/forum:

[Edited link out]

Long story short, MPB is an inflammation process that involves calcification of the scalp. There's a lot of disagreement in that forum topic, but ignore the haters, this method absolutely works. But it will take up to a year to regrow. Be patient.

Sorry if I repeated anything that's already been said here, I have not read any posts before writing this.

Good luck,

rew

how did you make your own.... what were your exact steps? do you double ferment? Kefir is packed with b vitamins , vitamin K, magnesium and probiotics. makes sense!

On 10/5/2014 at 9:11 AM, anonyy said:

Yes the lymphatic system & toxicity/acidosis doesn't exist because there is iridology that you can't understand. Bye man, you are a genius. Enjoy your health issues.

Looooook into my eyes!!!!! Quack Quack Quack

At least with you we don't even have to look at your eyes to see that you are stupid XDD

I really encourage you to tell cancer survivors that Morse saved that he's a quack. Go tell to the famillies of dying childs he saved too, that he's a quack and that they should have give him chemo and murder them.

There is only two possibilities, you support the official "medicine" or naturopathic stupid symptomatic treatment thinking who poison and kills billions each year (that is for the official one), or you support the understanding of physiology and the real causes of "diseases" who get their root inside the lymphatic system.

At least with you we don't even have to look at your eyes to see that you are stupid XDD

I really encourage you to tell cancer survivors that Morse saved that he's a quack. Go tell to the famillies of dying childs he saved too, that he's a quack and that they should have give him chemo and murder them.

There is only two possibilities, you support the official "medicine" or naturopathic stupid symptomatic treatment thinking who poison and kills billions each year (that is for the official one), or you support the understanding of physiology and the real causes of "diseases" who get their root inside the lymphatic system.

hey dummy, make some kefir stat, or go to the eye doctor.

There is only two possibilities, you support the official "medicine" or naturopathic stupid symptomatic treatment thinking who poison and kills billions each year (that is for the official one), or you support the understanding of physiology and the real causes of "diseases" who get their root inside the lymphatic system.

WTF? No middle ground eh? Guess that makes most of us bad people by default.

Hey tyringtohelp, just curious what your side effects are, how long you have been dealing with them, etc etc...

Here's some info from the horrible official medical establishment I just stumbled upon:

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011

http://www.biomedcentral.com/2050-6511/15/54

Results

There were 110 different drugs with20 reports of depression, 58 with 10 reports of non-fatal suicidal behaviour and 33 with 5 reports of fatal suicidal behaviour in the time period. The top five drugs with the most frequent reports of depression were the smoking cessation medicines varenicline and bupropion, followed by paroxetine (a selective serotonin reuptake inhibitor), isotretinoin (used in acne treatment) and rimonabant (a weight loss drug). Selective serotonin reuptake inhibitors, varenicline and the antipsychotic medicine clozapine were included in the top five medicines with the most frequent reports of fatal and non-fatal suicidal behaviour. Medicines with the highest reliably measured reporting rates of psychiatric ADRs per million prescriptions dispensed in the community included rimonabant, isotretinoin, mefloquine (an antimalarial), varenicline and bupropion. Robust denominators for community prescribing were not available for two drugs with five or more suicide reports, efavirenz (an antiretroviral medicine) and clozapine.

 

There is only two possibilities, you support the official "medicine" or naturopathic stupid symptomatic treatment thinking who poison and kills billions each year (that is for the official one), or you support the understanding of physiology and the real causes of "diseases" who get their root inside the lymphatic system.

WTF? No middle ground eh? Guess that makes most of us bad people by default.

Hey tyringtohelp, just curious what your side effects are, how long you have been dealing with them, etc etc...

Here's some info from the horrible official medical establishment I just stumbled upon:

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011 http://www.biomedcentral.com/2050-6511/15/54

>>>>>>>>>>>>

Results

There were 110 different drugs with20 reports of depression, 58 with 10 reports of non-fatal suicidal behaviour and 33 with 5 reports of fatal suicidal behaviour in the time period. The top five drugs with the most frequent reports of depression were the smoking cessation medicines varenicline and bupropion, followed by paroxetine (a selective serotonin reuptake inhibitor), isotretinoin (used in acne treatment) and rimonabant (a weight loss drug). Selective serotonin reuptake inhibitors, varenicline and the antipsychotic medicine clozapine were included in the top five medicines with the most frequent reports of fatal and non-fatal suicidal behaviour. Medicines with the highest reliably measured reporting rates of psychiatric ADRs per million prescriptions dispensed in the community included rimonabant, isotretinoin, mefloquine (an antimalarial), varenicline and bupropion. Robust denominators for community prescribing were not available for two drugs with five or more suicide reports, efavirenz (an antiretroviral medicine) and clozapine.

I took 1 course of the drug in 1992!! it was the lowest dose possible. I didnt really have too many side effects while on the drug... just the typical dry skin, lips, slight joint pain, hair shedding . The real side effects only start happening in the years following...my tendons started to slowly get more stiff, until the point where i could crack my hips and shoulders. in the years following, my digestion took a turn for the worse... just a constant stomach pain/bloat. My skin has never recovered. this is the main thing. it has remained bone dry, where it was oily before. example... if i get a mosquito bite and itch it to the point of being raw, that scar will be there for 6 months, where as before, it would be gone in days? the skin simply doesnt heal. if i get a pimple anywhere but on my face its the same thing... the scar will remain for months... almost like the oil gland turned on for a second to clean itself out, and then got turned off, stopping the healing part. the oil glands are simply shut off.

And as i mentioned before, i went on an extreme weight loss program designed to lose as much fat as possible (obviously thought it was trapped in the fat), in order to get this drug out of me.... towards the end of this program, i experienced all of the side effects as when on the drug...only x10... to the point where the skin on my palms and soles of my feet were peeling and literally hurt!!! my eyes hurt from being so dry. i would get nosebleeds! but....but... there was a small window, when i kind of broke thru and i swear i woke up one morning, and my skin was super oily again and i had some spots....i was happy to see this, but i was going thru extreme stomach pains and nausea at this point, and feeling just totally toxic along with joint pains!! its only when i stopped and started eating fat again, that the side effects lessened. its now 20+ years later and the joint problems are probably getting 5% worse per year as far as shoulder and tendon pain.... accutane alters the vitamin k2 metabolism telling your body where to put the calcium.... but my digestive problems/food sensitivity seems to be getting worse faster.

20 years of getting worse every day and you still believe in the bullshit you are telling us since the beginning and want others to do the same. Made my day.

I don't really believe that you are 35+ years old when i look how you act.

It's never too late to get your health back, you won't be truely yourself until you get rid of those lymph congestion and let your cells breathe. There is no deficiency, no vitamin blockage or other illusion, stop believing symptomaticly, wake up, we all already tried those stupid thing and wasted time and money.

20 years of being worse every day and you still believe in the bullshit you are telling us since the beginning and want others to do the same. Made my day.

assholes are like that.. im sure your eye doctor would have more compassion.

i only started trying to figure this out again last week... after the previous weight loss/detox episode... i just simply gave up and lived my life. now i will try again.

You are acting like a child, very stupidly, what you expect. You are trying to discredict a doctor who spend 40 years helping thousand of people, while you only succeed nothing, this guy deserve respect and you try to discredict thousand of saved lives by acting like a child saying "eye doctor hihihi". You don't deserve any compassion spitting on that and him. I'll keep my compassion for those who doesn't promote misinformation and who are not harming others with it. And to be honest i'm already saying what you need to do to get your health back, can't do much more, i even loose my time fighting your own ignorance.

Do I regret taking Accutane? How can I regret putting pills in my mouth while nobody forced me to?

I just did what most people do, receiving advice and pills from doctors.

I choose not to go around and tell people how Accutane fucked up my university grades and my hair.

NOTHING can fuck up your life apart from yourself!

This thread has made me very sad and depressed while i have nowhere else to go.

Do I regret taking Accutane? How can I regret putting pills in my mouth while nobody forced me to?

I just did what most people do, receiving advice and pills from doctors.

I choose not to go around and tell people how Accutane fucked up my university grades and my hair.

NOTHING can fuck up your life apart from yourself!

This thread has made me very sad and depressed while i have nowhere else to go.

Would you fault a child for eating parade candy that some sicko filled with glass?

The blame lies on Roche Pharmaceuticals and other manufacturers of Accutane, and to a large extent, the FDA for being enablers.

May anyone who knowingly had their hands in promoting a product capable of so much damage suffer all of the horrors life has to offer and burn in Hell.

Really, how can you blame yourself for this?

Do I regret taking Accutane? How can I regret putting pills in my mouth while nobody forced me to?

I just did what most people do, receiving advice and pills from doctors.

I choose not to go around and tell people how Accutane fucked up my university grades and my hair.

NOTHING can fuck up your life apart from yourself!

This thread has made me very sad and depressed while i have nowhere else to go.

at least we know what is haunting us, and we're all here with you, so youre not alone either.

 

Do I regret taking Accutane? How can I regret putting pills in my mouth while nobody forced me to?

I just did what most people do, receiving advice and pills from doctors.

I choose not to go around and tell people how Accutane fucked up my university grades and my hair.

NOTHING can fuck up your life apart from yourself!

This thread has made me very sad and depressed while i have nowhere else to go.

Would you fault a child for eating parade candy that some sicko filled with glass?

The blame lies on Roche Pharmaceuticals and other manufacturers of Accutane, and to a large extent, the FDA for being enablers.

May anyone who knowingly had their hands in promoting a product capable of so much damage suffer all of the horrors life has to offer and burn in Hell.

Really, how can you blame yourself for this?

People who invented and promoted the drug are the culprits.

BUT, realistically, we are just weak individuals. There will ALWAYS be things/people which/who try to fuck us up.

I did not have control over side effects gained from Accutane. I DO have control over my life.

I was in bad depression and filled with suicial thoughts a couple of months ago becos of my hair loss.

I decided to do sth and not to let this ruin my life.

Ironically, there are people who are more unfortunate than ourselves and yet more successful.

I do not fear for accutane hair loss. I fear for how I myself choose to ruin my life by not being able to live with this side effect.

 

Do I regret taking Accutane? How can I regret putting pills in my mouth while nobody forced me to?

I just did what most people do, receiving advice and pills from doctors.

I choose not to go around and tell people how Accutane fucked up my university grades and my hair.

NOTHING can fuck up your life apart from yourself!

This thread has made me very sad and depressed while i have nowhere else to go.

at least we know what is haunting us, and we're all here with you, so youre not alone either.

Thank you. I dont know whether it's sad or sweet to have people on my side in this situation. I hope everyone will be ok soon. Better later than never

Im not positive that my side effect will go away. I am very optimistic and believe that my life will be awesome no matter what.

Charcoal will only bind things in the intestine. Only some cells & enzyme can metabolize 13-cis retinoic acid, and i believe only the liver can bind it with glucuronic acid and expell it (again, human liver isn't adapted to handle high amount of preformed vitamin A, we are a frugivorus species, not like carnivorus who handle it very well). I don't think that charcoal can reach any molecule stuck inside the wall & the lymphatic system of the intestine. The best theory about that is the long fermented kombucha & the d-glucarate. The problem is that it's not the accutane molecule that cause the biggest problems, it's also the converted form all-trans retinoic acid.

I took beta carotene & fermented skate liver oil (+charcoal & other things) in my last experiments before understanding physiology and from what i experienced, it maked me feel better and worse at the same times, i can't really explain why. I took those for almost a year, i believe that fixed my eyes issue since i had to take glasses after accutane (i hated it only used them 2month) and now, i see blurry with those and my eyes are now perfect.

Two theories the body become highly deficient in some form/metabolite of vitamin A after accutane* and/or it can put into circulation some accutane residue. The liver only convert beta-carotene into vitamin A if he need it, you can't overdose with beta-carotene. But anyway, if you want to expell accutane faster, in the theory it's still in us (highly doubt it), the best way is always the same, clearing the lymphatic system, getting your kidneys filtering that lymph who will permit your organs to be freed from their obstruction/congestion & they will do their job at restoring the balance. I only saw very limited results before detoxing & changing my diet, like everyone else.

Everyone person who doesn't take into account the lymphatic system (cleansing system) which is 3 times bigger than the blood system will never understand health issue.

* http://www.westonaprice.org/health-topics/the-pursuit-of-happiness/ the only one interesting study i saw. Don't take any preformed vitamin A after accutane until at least after 2-3 years (like i did), plus the human body isn't made for it so don't take it at all (didn't knew it at that time). Beta-carotene is fine since the body convert it when he need it.

Your absolutely right anonyy about simultaneous toxicity and deficiency. I have a horrendous reaction to eating anything with retinol in it, even to this day. Over a long period of time it can cause other problems not just skin, hair loss, cracked lips, cracking joint's, but actually migrate to things like testicular damage, nerve damage, further liver damage through the circulation of accutane after eating retinol foods. In my case the accutane was not removed because i was sick in the first place when i took the drug, i just didn't realise the acne was actually a case of a deeper underlying problem. One of more of my liver, kidney's, colon or lymph was not filtering properly and the drug was not detoxifyed as it should be.

Your right though, classically accutane victims display a vitamin A toxicity evidenced by cracked lips, dry skin, no sebum production, hair loss, joint pains etc, but after a certain time of avoiding vitamin A they also develop simultanous deficiency in areas where other forms of retinol, like retinol / retinal etc are used like eye health, so it's a double edged sword.

I've got a question for you, why does eating grains / legumes impinge on detoxification of the lymph?