Anginver.. i started a group called- [removed]. As i put some of what was happening with my son on their.. My son took Isotretinoin 3 years ago just before his 17th birthday.. Needless to say he has been home for nearly 3 years now doing nothing ..

Mitch UK

Really hope that when cannabis oil goes mainstream it puts Roche and other pharmaceuticals out of business. CBD has been shown to cure acne so hopefully certified pimple poppers (dermatologists) lose their jobs too.

Anginver.. i started a group called- Acne Medication Isotretinoin on facebook. As i put some of what was happening with my son on their.. My son took Isotretinoin 3 years ago just before his 17th birthday.. Needless to say he has been home for nearly 3 years now doing nothing ..

Mitch UK

Hi Mitch,

I'm glad to hear there is an understanding parent here, I can whole heartedly this drug is a nightmare for some. I've said to my parents that this drug has made me contemplate suicide although I stressed I wouldn't. They luckily on the whole have been very supportive and without them I don't know how I would be coping. If you or your son would like to chat I'd be more than happy too.

Regards,

Mike

Interesting Dubya, I will probably give this fast a go sometime. Think vaping a bit will give me the appetite to put on a bit of weight in the meantime

Everything is a part of a whole thing, those NF-kappaB, androgen receptors mean nothing by themselves. It doesnt take into account the whole problem, the source of it, here you are just talking of symptoms, not causes. Modern drug-medicine will never cure anything cause they always focus on symptoms and not the cause.

Not strictly true once again. Take syphilis for example that is a bacteria that produces a set of symptoms, therefore the syphilis bacteria is the cause of the symptoms. You take penicillin to destroy the offending bacterium thereby tackling the cause and not the symptoms. However, I presume syphilis is due to liver blockage of some sort?

It's not true, if the body is in good/normal condition there is no disease, syphilis is not the main cause again, disease can only appear in congestioned & toxic tissue, the part of the body who is the most obtrued by toxins are the intestine, who poison the rest of the body. Just like the candida for example is here to help cleansing the intestine from the bad kind of food we ate. But of course the process can degenerate and get out of control if the body is in too bad condition.

Dubya - I think I took tane in 09 and my symptoms progressively got worse until maybe the half year mark. Other minor concerns bega to crop up as well. I think I finally started noticing in the mirror improvements 3 years after, and oddly enough, it was the in '12 that I saw most of my improvements. IIRC, I was feeling 50-60% better in 11/12 before it catapulted to 95% in the last year.

It's also why I'm not sure if it was simply a product of the waiting game or making so many lifestyle adjustments.

Hi all,

it took a little longer than expected but today the RSO arrived. I just started with the therapy and took 3 drops from the oil. If you guys are interested I can update you on the progress.

Correct look into the fraudulent Germ Theory for starters..... it's not the germ but the terrain.

Hi all,

it took a little longer than expected but today the RSO arrived. I just started with the therapy and took 3 drops from the oil. If you guys are interested I can update you on the progress.

Hi Roland, please do keep us updated. Although by the looks of it this could be a long progress (TA took it for 5 months). Also I presume you probably have mentioned your sides previously but could you give us a reminder please?

Hi Mike...

i will point my son in this direction. Im not sure if he's aware thst i use these sites to compare notes so to speak. He cannot look at screens for long as he has permanent migraine. And to be honest i guess i tried to protect him by not telling him about other peoples experiences. He was really angry & depressed and i didnt want him feeling thst there was no hope & doing something terrible

mitch UK

 

Hi all,

it took a little longer than expected but today the RSO arrived. I just started with the therapy and took 3 drops from the oil. If you guys are interested I can update you on the progress.

 

Hi Roland, please do keep us updated. Although by the looks of it this could be a long progress (TA took it for 5 months). Also I presume you probably have mentioned your sides previously but could you give us a reminder please?

I took accutane more than 10 years ago and I still suffer from:

* excessive dry skin (getting worse every year)

* thin skin

* super sensitive skin (especially against sunlight)

* dry eyes

* i react with migraine to any sun-blocker or moisturizer (headache + oversensitivity to noise, light)

* dry, strawy, thin hair

* permanently tired and nervous

It is especially the combination of super sensitive skin and intolerance of moisturizer/sunblocker, that makes my life to hell. In summer it is impossible for me to be outside for a longer time. I wear a baseball cap and sunglasses almost everyday to protect skin and eyes. I used to be a sports guy. Triathlon, windsurfing, skiing. Outdoor every day. This is all water under the bridge now. It haunts me every day, that I have taken this drug. It completely ruined my life. Angriness and desperation are awakening in me when I talk about those things.

What was your dosage?

A French petition against isotretinoin/Accutane:

http://www.avaaz.org/fr/petition/Reglementation_sur_les_medicaments_a_base_disotretinoine_Procuta_Curacnee_ContracneIsotretinoine_Teva/?copy

Translated

Today November 2, 2013, The Roaccutane is removed from the French market, but isotretinoin molecule is still sold as generic (Procuta, Curacnee, Contracne, Isotretinoin). Despite the information from May 2000 (modification on the package insert on side effects, depression, psychotic syndromes, suicidal ideation, suicide attempts), Medicine continues to wreak havoc. We seek from you particular interest to the dangers of this drug and the urgency of the need.

It's a petition who claim wanting a regulation, not a suppression :/

I don't really know much about epigenetics but i know DNA methylation plays a part in it. If you look at the propecia site a lot of people are claiming to feel better after trying methylating agents. Just read that CBD "increases global DNA methylation levels."

On 1/26/2014 at 6:02 AM, acne1776 said:

I don't really know much about epigenetics but i know DNA methylation plays a part in it. If you look at the propecia site a lot of people are claiming to feel better after trying methylating agents. Just read that CBD "increases global DNA methylation levels."

Nice find! Looks as if CBD is an epigenetically active substance.

Not sure where you read that, but I came across this article in Scholar in the strangest format I've seen. All the author's sources check-out though:

[Edited link out]

Quote

Treatment of differentiated human keratinocytes cells with CBD led to increased DNA methylation of keratin 10 gene and reduced its expression. CBD increased global DNA methylation levels by selectively enhancing DNA methyltransferase (DNMT1) expression,without affecting DNMT 3a, 3b or 3L

So, there's a good chance CBD drastically and selectively upregulates expression of DNMT1. I think that's kind of a good sign since it means its effects aren't "sloppy" like many epigenetic drugs.

The strange thing is that in the past, people have associated our condition with gene silencing, which usually involves hypermethylation

Hypomethylation often leads to a gene being strongly over-expressed. (opposite of silenced)

Since we don't really know what's going on it is difficult to say one way or the other.

I think the supplements some of the guys on the Propecia site are taking help increase the amount of raw material (methyl groups) available for the DMNT enzymes to do their job. I'm not sure of that though. They don't seem to be having huge benefits from their treatment protocol either, just a few guys saying it helps a little.

Here is the study showing increased DMNT1 activity if you're interested, although it may be the article you were talking about:

[Edited link out]

Thanks for pointing this out 1776.

Is anyone here in contact with Scott from the Medschat thread? I want to speak with him, but their damn site won't let me post messages because I tried sending a link.

Guys you realize that even if this theory of permanent "epigenetic" modification was true (its 100% false), it is not with adding things that it will be "fixed", if the body doesnt do it by its own it will never be done by anything else. Temporarly genetic expression change are naturals, it get back to normal as soon as what cause the change go away and if the body have the possibility to do so.

Yes, there is also a France RAGFOURM for Victims. So anyone who knows French or are from France, you can seek help there also. [Edited link out]

It won't let me paste links here so you can type it in. There is also a victim forum for those in Swiss countries.

Great it finally came off the market in France! [Edited image out] It will be a harder battle for Generics. There was a petition on change.org that posted all over the place for generics, yet we couldn't get enough signatures to do anything

Hope all is well

I hate to tell you epigenetics is a real plausible explanation, especially since if you get pregnant on Accutane it causes epigenetics of the fetus. I believe in some maybe they are not damaged to the extreme and so they may get away with diet and life style changes, however that is not the case with every victim. We are all different yet suffer some of the same things, I believe this poison changes DNA in some.

Diet worked for you, doesn't mean for everyone!

No, epigenetic theory is 100% false. Everything that get in contact of the body cells act on dna expression, accutane included, it is not abnormal. You again focus on symptoms, epigenetic is one of them (in the case of accutane), the source of the problem is the accutane molecule and its induced toxicity as it cause a global toxicity by destroying the third kidney (the skin), the intestine & liver, and affect the adrenals who build and control the most important hormone & neurotransmitters of the body.

And again, you don't get cured with diet, i never said that, i already said 10000000 times, diet is about "do no more arm".

And like i said, even if the permanent epigenetic change was true, if the body doesnt restore it back by himself, nothing else will do, how do you want that something precisely target precise cells who have been modified and precisely reverse back the precise dna expression mechanism of 13-cis retinoic and all-trans-retinoic acid, it is 10000% impossible.

I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

Great to hear CBD is helping! What kind of CBD oil are you taking? Is it Rick Simpson Oil (which has THC in it), Real Scientific Hemp Oil, etc?

On 1/27/2014 at 6:15 AM, acne1776 said:

On 1/27/2014 at 6:12 AM, Ottovisual said:

I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

Great to hear CBD is helping! What kind of CBD oil are you taking? Is it Rick Simpson Oil (which has THC in it), Real Scientific Hemp Oil, etc?

I ordered from this website:

[Edited link out]

It's Dutch and from the Netherlands, so I dont know anything about international restrictions.

Submitted for your approval anonyy:

DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory

[Edited link out]

This directly contradicts that all persistent DNA methylation is impossible to reverse. Sometimes you just have to nudge things in the right direction to reverse it.

Pretty sure the study referenced in my previous post was pertaining to "permanent" downregulation of a keratin-producing gene involved in causing psoriasis. This was achieved by increasing DNMT1 with CBD. Pretty precise from the sounds of it.

So, long-term epigenetic marks are able to be removed. The question is how. Sometimes one's own body will not do this by itself.

Otto, thanks for sharing this with us. Please keep us updated on how things are going for you.

Can I ask you to list the symptoms you had after tane, and how long ago you first noticed them?