I took 40mg for a duration of 3 months..

On 10/17/2013 at 2:12 AM, Gladiatoro said:

How many mg did you take of isotretinoin ?

On 10/17/2013 at 12:38 AM, sunnyhatesacne said:

On 10/11/2013 at 2:38 PM, anonyy said:

On 10/11/2013 at 9:42 AM, shadeo14 said:

On 9/29/2013 at 6:38 PM, anonyy said:

Guys are you serious. I've already told you how to flush out this accutane.

Accutane is expelled via the bile, the best thing to expell all the bile without reabsorption is the liver flush by andreas moritz.
You do 6-10 liver flush, 1-2 kidney cleanse and then you do the homeopathic isotherapy like this (i did it in the morning, 30 min before eating) day 1: 30K, day 3: 200K, day 5: XM, day 7: XMK.

While doing this isotherapy you need to take 7+day fermented kombucha (who potentially contain udp-glucuronic acid & glucaric acid) + 1 supplement of calcium-d-glucarate (1-2gr 3times per day) + food (artichoke) or supplement (chondroitin, artichoke extract) who contain glucuronic acid (facultative) + a lot of fiber (eat only fruit & vegs**), we can add: psyllium, bentonite, charcoal to prevent reabsorption. This isotherapy isn't easy cause it will bring all the symptoms back for 1-3 weeks but it will be fucking magical to get your old body back [Edited image out]

** I've took 20ml of olive oil + 20ml lemon juice after eat some fruits and psyllium+bentonite+charcoal to expell all the bile every morning.

PS: I think it's a good idea to have a good stock of real vitamin A & vitamin D (from sun exposure) before doing the isotherapy, that's what i did, i've eat some carrots & took red ice skate liver oil.
I don't know if it's matter but i've took nux vomica (at the same dosage) 10min after the isotherapic isotretinoin.

Great to hear this worked! Can you explain it more in a step-wise way? Did you do the liver flush for X number of days, then the kidney flush, then 7 days of isotherapy? What can and can't you eat on the isotherapy?

I can't tell if i did it the best way but i did first one kidney flush (3week) and then 10 liver flush. the next day of the 10th flush i started the isotherapy.
I avoided dairy & gluten and took only a little bit of chicken & eggs (only cook with water to not oxyde the cholesterol). best thing is to eat only fruit & vegetables.
For the olive oil + citrus in the morning it's really your choice for the method, cause the isotherapy work for 6weeks so you can do it only 1/2 week or only with low dose everyday or every two day, i took a dose who doesnt cause fatigue for me.
For the calcium-d-glucarate it's better to only take 500mg 2 or 3times i think, when i took more i was a little bit tired.

Hi Annoyy I have also started taking Calcium d glucrate but for some reason the first 2 day i took it i got really terrible migrane headaches.. Now the headaches are gone but still they make feel very sleepy and tired ... It is really annoying that sometimes i feel full of energy .. The sex drives increases so much, the muscle pain goes away and then in couple of hours i feel so sleepy and tired again...

I started off with 500 mg daily and is trying to progress to 750 mg but it is making me feel very tired.. do you have any ideas on how i can increase my intake ? Also, how long you took it?

So around 3600 mg , consider your self lucky you didn't take more , less damage obviously. I'm around the same range 3000 mg , doc wanted me to take 10.000 grams or so I told him to ^&*( off after my hair loss kicked in and I started to get dizzy . Best decision I ever made other than taking the initial 3 grams or so.

The people that took lots they have massive health problems usually but some are more susceptible to the poison it varies . I still don't understand how this S$$$ is legal , because in reality it is pure toxic poison and what gets me is it stays in the system that almost seems unbelievable but true , modern day witchcraft really. Allopathic medicine at it's best.

Typical CUT , POISON , BURN approach. And like I said it's symptom management really that is what it is. Be careful with what you ingest some things are bad for us , dht blockers , anti androgens , retinol , alcohol any including beer ,

that's all I can think of for now oh prolonged rubbing ie acne creams etc worsens symptoms , saunas , nettle tea ( left arm went numb for a month), dead sea salt baths , Vitamin A free fish oil (caused a three day back seizure) , since our skin cell receptors are permanently ^&*( up this is where the problem arises ie re-activation , trial and error for me over the years. A lot of herbs are dht blockers ...... who knows what else likely more....... and they call it a MIRACLE DRUG yeah sure... miracle drugs don't exist more like miracle poison. I seem to do my best on nutritionally dead food it's true then I pretty much don't have any symptoms how backwards is that.

I took 40mg for a duration of 3 months..

On 10/17/2013 at 2:12 AM, Gladiatoro said:

How many mg did you take of isotretinoin ?

On 10/17/2013 at 12:38 AM, sunnyhatesacne said:

On 10/11/2013 at 2:38 PM, anonyy said:

On 10/11/2013 at 9:42 AM, shadeo14 said:

On 9/29/2013 at 6:38 PM, anonyy said:

Guys are you serious. I've already told you how to flush out this accutane.

Accutane is expelled via the bile, the best thing to expell all the bile without reabsorption is the liver flush by andreas moritz.
You do 6-10 liver flush, 1-2 kidney cleanse and then you do the homeopathic isotherapy like this (i did it in the morning, 30 min before eating) day 1: 30K, day 3: 200K, day 5: XM, day 7: XMK.

While doing this isotherapy you need to take 7+day fermented kombucha (who potentially contain udp-glucuronic acid & glucaric acid) + 1 supplement of calcium-d-glucarate (1-2gr 3times per day) + food (artichoke) or supplement (chondroitin, artichoke extract) who contain glucuronic acid (facultative) + a lot of fiber (eat only fruit & vegs**), we can add: psyllium, bentonite, charcoal to prevent reabsorption. This isotherapy isn't easy cause it will bring all the symptoms back for 1-3 weeks but it will be fucking magical to get your old body back [Edited image out]

** I've took 20ml of olive oil + 20ml lemon juice after eat some fruits and psyllium+bentonite+charcoal to expell all the bile every morning.

PS: I think it's a good idea to have a good stock of real vitamin A & vitamin D (from sun exposure) before doing the isotherapy, that's what i did, i've eat some carrots & took red ice skate liver oil.
I don't know if it's matter but i've took nux vomica (at the same dosage) 10min after the isotherapic isotretinoin.

Great to hear this worked! Can you explain it more in a step-wise way? Did you do the liver flush for X number of days, then the kidney flush, then 7 days of isotherapy? What can and can't you eat on the isotherapy?

I can't tell if i did it the best way but i did first one kidney flush (3week) and then 10 liver flush. the next day of the 10th flush i started the isotherapy.
I avoided dairy & gluten and took only a little bit of chicken & eggs (only cook with water to not oxyde the cholesterol). best thing is to eat only fruit & vegetables.
For the olive oil + citrus in the morning it's really your choice for the method, cause the isotherapy work for 6weeks so you can do it only 1/2 week or only with low dose everyday or every two day, i took a dose who doesnt cause fatigue for me.
For the calcium-d-glucarate it's better to only take 500mg 2 or 3times i think, when i took more i was a little bit tired.

Hi Annoyy I have also started taking Calcium d glucrate but for some reason the first 2 day i took it i got really terrible migrane headaches.. Now the headaches are gone but still they make feel very sleepy and tired ... It is really annoying that sometimes i feel full of energy .. The sex drives increases so much, the muscle pain goes away and then in couple of hours i feel so sleepy and tired again...

I started off with 500 mg daily and is trying to progress to 750 mg but it is making me feel very tired.. do you have any ideas on how i can increase my intake ? Also, how long you took it?

I only took 10mg daily for a month, then a maintenance dose of 10mg a week for a couple of months, so probably only 500mg total and it's been enough to have a serious effect. 3 years on I'm still suffering - low libido/ED, brain fog are the main problems for me.

a quick google of kombucha tea shows it can be quite dangerous if brewed improperly even causing death. were you not going to give anyone a heads up on this? and how were you buying this ? kombucha is some sort of mushroom that you let ferment? up to 14 days seems more dangerous to allow for the growth of harmful bacteria and mold. i did see a prepackaged one on amazon mixed with green tea. do you believe this would have the same effect?

Welcome to the Accutainted club. Were here to help.

I only took 10mg daily for a month, then a maintenance dose of 10mg a week for a couple of months, so probably only 500mg total and it's been enough to have a serious effect. 3 years on I'm still suffering - low libido/ED, brain fog are the main problems for me.

There are tons of scientists out there that says Vitamin D, E, etc. doesnt do anything. No one however doubts the benefits of Vitamin C.

It is proven and pretty much bullet proof.

http://www.naturalnews.com/042541_vitamin_C_natural_cures_Andrew_W_Saul.html

Same thing for me my doctor wanted that i take a total of 9600 mg but the side effects started to kick in after 3 months and i couldn't tolerate it... So, I had to quit it in the mid way .. I am so thank ful that i made the right decision at that time other wise i would have pretty much gone...

I have been doing lots of research on the accutane or 13-cis Retinoic acid. The only way our body can get this out of the system is through liver detoxification. Our body has natural way of detoxifying the drugs which is a 2 step process.

1. Oxidation : Mediated by P450 Enzymes ( Addition of OH bond to acid)

2. Conjugation : For Retinoic this is by glucuronidation and the particular enzymes responsible for this is UGT1A9. ( Addition of the conjugate bond to oxidized acid so it becomes water soluble)

http://dmd.aspetjournals.org/content/38/7/1211.full

The problem is that the oxidation can make the non-toxic things really toxic . The things that do oxidation are :

1. Consuming omega -3

2. Consuming fatty foods

3. Doing Sauna's

4. Epsom Salt Bath

5. Consuming olive oil or any other type of oil

6. Apple cider vinegar

7. Garlic

8. Consuming alchoal

9......

So, we start getting the effects of accutane toxification in our body again..

The second step is conjugation which can make them non-toxic and make them water soluble so they can be removed either through urine (mostly) and rest through stool.. I am currently doing some research on it and it looks from the chemistry point of view that this can be sped up by the use of Calcium d glucrate, Kambucha .. The main enzyme responsible for this is called UGT1A9.. There are some factors that can increase the excretion like:

1. Acute infections : http://www.ncbi.nlm.nih.gov/pubmed/9808228

2. Pregnancy

3. Having chronic diabetes diseases

4. HIV

I am sure we don't want to have any of these but still need to investigate more on how UGT1A9 enzyme efficiency can be increased and how beta-glucuronidation (converting conjugate back to oxidized stage for storage) can be decreased.. May it is as simple as having Calcium d glucrate, Kambucha which happened for Annoyy.. It also boils down to efficiency of your UGT1A9 which is nothing but genetics...

On 10/17/2013 at 3:35 AM, Gladiatoro said:

So around 3600 mg , consider your self lucky you didn't take more , less damage obviously. I'm around the same range 3000 mg , doc wanted me to take 10.000 grams or so I told him to ^&*( off after my hair loss kicked in and I started to get dizzy . Best decision I ever made other than taking the initial 3 grams or so.

The people that took lots they have massive health problems usually but some are more susceptible to the poison it varies . I still don't understand how this S$$$ is legal , because in reality it is pure toxic poison and what gets me is it stays in the system that almost seems unbelievable but true , modern day witchcraft really. Allopathic medicine at it's best.

Typical CUT , POISON , BURN approach. And like I said it's symptom management really that is what it is. Be careful with what you ingest some things are bad for us , dht blockers , anti androgens , retinol , alcohol any including beer ,

that's all I can think of for now oh prolonged rubbing ie acne creams etc worsens symptoms , saunas , nettle tea ( left arm went numb for a month), dead sea salt baths , Himalayan salt baths , Vitamin A free fish oil (caused a three day back seizure) , Epson salt baths , since our skin cell receptors are permanently ^&*( up this is where the problem arises ie re-activation , trial and error for me over the years. A lot of herbs are dht blockers ...... who knows what else likely more....... and they call it a MIRACLE DRUG yeah sure... miracle drugs don't exist more like miracle poison. I seem to do my best on nutritionally dead food it's true then I pretty much don't have any symptoms how backwards is that.

I took 40mg for a duration of 3 months..

On 10/17/2013 at 2:12 AM, Gladiatoro said:

How many mg did you take of isotretinoin ?

On 10/17/2013 at 12:38 AM, sunnyhatesacne said:

On 10/11/2013 at 2:38 PM, anonyy said:

On 10/11/2013 at 9:42 AM, shadeo14 said:

On 9/29/2013 at 6:38 PM, anonyy said:

Guys are you serious. I've already told you how to flush out this accutane.

Accutane is expelled via the bile, the best thing to expell all the bile without reabsorption is the liver flush by andreas moritz.
You do 6-10 liver flush, 1-2 kidney cleanse and then you do the homeopathic isotherapy like this (i did it in the morning, 30 min before eating) day 1: 30K, day 3: 200K, day 5: XM, day 7: XMK.

While doing this isotherapy you need to take 7+day fermented kombucha (who potentially contain udp-glucuronic acid & glucaric acid) + 1 supplement of calcium-d-glucarate (1-2gr 3times per day) + food (artichoke) or supplement (chondroitin, artichoke extract) who contain glucuronic acid (facultative) + a lot of fiber (eat only fruit & vegs**), we can add: psyllium, bentonite, charcoal to prevent reabsorption. This isotherapy isn't easy cause it will bring all the symptoms back for 1-3 weeks but it will be fucking magical to get your old body back [Edited image out]

** I've took 20ml of olive oil + 20ml lemon juice after eat some fruits and psyllium+bentonite+charcoal to expell all the bile every morning.

PS: I think it's a good idea to have a good stock of real vitamin A & vitamin D (from sun exposure) before doing the isotherapy, that's what i did, i've eat some carrots & took red ice skate liver oil.
I don't know if it's matter but i've took nux vomica (at the same dosage) 10min after the isotherapic isotretinoin.

Great to hear this worked! Can you explain it more in a step-wise way? Did you do the liver flush for X number of days, then the kidney flush, then 7 days of isotherapy? What can and can't you eat on the isotherapy?

I can't tell if i did it the best way but i did first one kidney flush (3week) and then 10 liver flush. the next day of the 10th flush i started the isotherapy.
I avoided dairy & gluten and took only a little bit of chicken & eggs (only cook with water to not oxyde the cholesterol). best thing is to eat only fruit & vegetables.
For the olive oil + citrus in the morning it's really your choice for the method, cause the isotherapy work for 6weeks so you can do it only 1/2 week or only with low dose everyday or every two day, i took a dose who doesnt cause fatigue for me.
For the calcium-d-glucarate it's better to only take 500mg 2 or 3times i think, when i took more i was a little bit tired.

Hi Annoyy I have also started taking Calcium d glucrate but for some reason the first 2 day i took it i got really terrible migrane headaches.. Now the headaches are gone but still they make feel very sleepy and tired ... It is really annoying that sometimes i feel full of energy .. The sex drives increases so much, the muscle pain goes away and then in couple of hours i feel so sleepy and tired again...

I started off with 500 mg daily and is trying to progress to 750 mg but it is making me feel very tired.. do you have any ideas on how i can increase my intake ? Also, how long you took it?

Yes it's the strategy, isotherapy to mobilize (in theory), and then expell it with calcium d glucarate, kombucha, artichoke (glucuronic acid), beetroot apple for liver detox nutrients, charcoal psylium bentonite to prevent reabsorption & egyptian liver flush (10-30ml olive oil + lemon juice each morning) after take the charcoal to flush out all toxins. It worked for me.
But doing some "full" liver & kidney flush (moritz/clark) before doing this is important to be in the best conditions.

Maybe its important to have enough true vitamin A while doing this isotherapy, we don't need the body to not flush it out cause he has a deficiency.

Anonyy don't you think this is too much for body to handle like charchoal psyllium bentonite (all are laxatives).. So that means that we will be in washroom for doing obvious thing..

Yes it's the strategy, isotherapy to mobilize it, and then expell it with calcium d glucarate, kombucha, artichoke (glucuronic acid), beetroot apple for liver detox nutrients, charcoal psylium bentonite to prevent reabsorption & egyptian liver flush (10-30ml olive oil + lemon juice each morning) after take the charcoal to flush out all toxins. It worked for me.
But doing some "full" liver & kidney flush (moritz/clark) before doing this is important to be in the best conditions.

Maybe its important to have enough true vitamin A while doing this isotherapy, we don't need the body to not flush it out cause he has a deficiency.

no x) just dont take too much. i took a supplement who contain this: Argile verte poudre 300 mg ; Bistorte racine 300 mg ; Bourdaine ecorce 300 mg ; Cascara ecorce 300 mg ; Charbon vegetal 300 mg ; Gingembre racine 300 mg ; Guimauve racine 300 mg ; Orme ecorce 300 mg ; Ispaghul (Psyllium rose) teguments 300 mg ; Verge d'or plante 300 mg
its a french supplement.

Anyone know what happened to sheefa?

Anybody know what happened to Joseph?

I think I told you to try and pm him! For some of us old timers we take long breaks from the forum. He acutally posted my story on this forum from another forum, though I haven't spoken to him in about a year.

His last post and the last time I spoke to him was updating that he was taking medication Lyrica (or generic version) for the pain and he was under the care for his side effects by Dr. Chu in which in one post of his he posted his letter from him on here. go to his profile you can bring all his posts up from 2008!

 

Anyone know what happened to sheefa?

Anybody know what happened to Joseph?

no x) just dont take too much. i took a supplement who contain this: Argile verte poudre 300 mg ; Bistorte racine 300 mg ; Bourdaine ecorce 300 mg ; Cascara ecorce 300 mg ; Charbon vegetal 300 mg ; Gingembre racine 300 mg ; Guimauve racine 300 mg ; Orme ecorce 300 mg ; Ispaghul (Psyllium rose) teguments 300 mg ; Verge d'or plante 300 mg

its a french supplement.

Anonyy what you have done completely makes sense from the science point of view..

Liver:

Oxidation : Mediated by the olive oil and lemon, isotherapy

Conjugation : Mediated by the kambucha, calcium d glucrate, beet root, artichoke

Bile:

Excretion : Psyllium, Charchoal, bentonite (Breaking the entroheptatic cycle for drug)

I think these all makes sense from theory point of view but only if they work for me... I am very happy for you Anonyy that these things made a difference for you. One day hopefully i will also be able to get rid of this Accutane..

So anyone planning on trying anonyys method?

anonyy - interested to know where you were told about this method - was it by a homopath? Did you come up with the method yourself? Pleased to hear it has worked for you anyway!

you might wanna try liv52, silymarin, bentonite and especially high vitamin b complexes for detoxification. tried around with different doses with each of these supps very recently, feels like isotheraphy to me, had to stop because the sides got so bad as never before. just saying that in case you don't wanna take iso again. focusing now again more on building myself up, maybe give it another try during my next vacation or so, not really to manage if you are interested in going to university or work in the meantime.

I have tried this method without knowing all the steps. I tried just the oxidation step for almost 1 month without knowing about other steps. It made the things really bad for me.. Know I have been planning to rest my body for at least 2 months and then retry the above mentioned method ..

One thing I really found amazing while I was on oxidizing stage my other accutane symptoms got better but had burning sensation in stomach.. I could really feel how the accutane was moving in my body from head and then to back to my stomach to my sexual organ and then back again..

So anyone planning on trying anonyys method?

anonyy - interested to know where you were told about this method - was it by a homopath? Did you come up with the method yourself? Pleased to hear it has worked for you anyway!

its from what i already tried and find by doing research on google, forums, website...

I have tried this method without knowing all the steps. I tried just the oxidation step for almost 1 month without knowing about other steps. It made the things really bad for me.. Know I have been planning to rest my body for at least 2 months and then retry the above mentioned method ..

 

One thing I really found amazing while I was on oxidizing stage my other accutane symptoms got better but had burning sensation in stomach.. I could really feel how the accutane was moving in my body from head and then to back to my stomach to my sexual organ and then back again..

was taking liv52 and bentonite/psyllium together, which would be step one and three, doubt that artichoke would have made the situation better.

I thought I would just post a random and upbeat post! My daughter who is 16 and a sophomore performed her first lead this weekend and will perform in front of judges next week to qualify for state [Edited image out]

I guess that I just feel grateful even after all the damage and diseases Accutane gave me I am still here to enjoy these small moments.

Hope all is well with everyone....

Still here, still healthy, still working full time, still improving.

Eating only whiteleg shrimp and white rice and water. Moderate portion control is sufficient.

Try to avoid eating after sundown. Avoid protein late at night. Take 1.5g/d UDCA +. Two source naturals essential enzymes pills with rice. Also take UDCA and colostrum powder with rice. Cycling testosterone cream.

Fixed weekly fatigue cycle by not sharing bed with gf on weekend visits. Now at 7d/week uptime.

Blue Ice Fermented Cod Liver OIl / Butter Oil blend in mornings.

Limit light exposure after sundown. Get light exposure at sunrise.

That's it. Regimen is now pretty robust and fault tolerant. Model accurately predicts tomorrow's health.

KPI tracking switched from dumps to daily uptime, because IBS no longer central.

Finally got my Blue Ice fermented non-flavored CLO. Been taking it for only 4 days and it looks like my skin is already improving, I can't believe it. I don't take butter oil with, too expensive for now.

As the CLO is working so good I looked deeper into the potential mechanisms. The fermented CLO seems to be a good source of Vit K2.

On wikipedia it says:

Another at-risk group for deficiency were those subject to decreased production of K₂ by normal intestinal microbiota, as seen in broad spectrum antibiotic use.^[42] Taking broad-spectrum antibiotics can reduce vitamin K production in the gut by nearly 74% in people compared with those not taking these antibiotics.^[43].

Given that I have digestive issues and have used antibiotics I may have killed off some of the bacteria that were supposed to supply me with adequate amounts of K2. Natto is a very good source, maybe the cheapest source to increase the K2 uptake.

Has anybody on here tried Natto? I know Joseph could not take it. The only Natto I found was really high in sugar, is this how it was traditionally made, I don't know yet, but I suspect that is the reason why Joseph crashed on Natto?!

http://en.wikipedia.org/wiki/Natto

Seaweeds contain detoxing properties as does chlorella and other algaes. Miso has a protective effect on radiation poisoningit's unrelated but radiation is a fat soluble chemical..often damaging thyroid, hormone function and is stored in body fat. Fermented foods like unpasturized miso, unpasturized natto, unpasturized sauerkraut & Kimchi may have beneficial affects on regulating bowel movements, immunity and auto immune conditions as well as being part of a diet conducive to healing.

Thyroidseaweeds and algaes will help that, Adrenals have to be paid attention too if thyroid is a problem, nutritionally speaking Vitamin D3 may be something people might want to consider also, as is a natural fermented source of K2 like miso or natto. I'm sure the constipation is linked to the thyroid...

You tried Natto?

I crash on damn near everything. I would say the natto crash was almost certainly multi cause. I can't even recall if I took it specifically or something related such as tofu or fermented rice or whatever. Any ferment with alcohol kills me. Hell Dr. Ohhira probiotics killed me.

Now that I've stabilized I'll look at reducing sensitivity with gut lining rebuilders. My data is clean enough to proceed.

The CLO is working so well for me it is amazing, I hit the jackpot again. I had been wanting to buy it for years.

What I am asking myself is what is causing the amazing results? Is it the iodine, the D2, the Omega 3, the Vit A???

I have supplemented omega 3 before, it works, but the effects are to small for my budget to be constantly supplementing omega 3s.

I have supplemented Iodine recently, but only sporadically. Has anyone been able to find out how much iodine is approximately in a ml of FCLO?

Hi Navile I believe the main thing is the Step 2 where the conguation happens.. Oxidation and excretion (Step 1 and Step 3) happens easily..

Even if you read an researches the main intention of these researches is only Conguation or for specifically Retinols it is "glucuronidation" ...

The drug toxicity can only be removed by conguation where it is converted from Fat soluble oxidised product to water soluble compound which can be excreted either by urine or through fecals..

 

I have tried this method without knowing all the steps. I tried just the oxidation step for almost 1 month without knowing about other steps. It made the things really bad for me.. Know I have been planning to rest my body for at least 2 months and then retry the above mentioned method ..

One thing I really found amazing while I was on oxidizing stage my other accutane symptoms got better but had burning sensation in stomach.. I could really feel how the accutane was moving in my body from head and then to back to my stomach to my sexual organ and then back again..

was taking liv52 and bentonite/psyllium together, which would be step one and three, doubt that artichoke would have made the situation better.

One more thing that will work guaranteed 100%... Please take a look at this procedure developed by Dr Kim Brouwer.. This procedure basically involves the bile fluids drainage..

https://pharmacy.unc.edu/Directory/kbrouwer/faculty-spotlight-kim-l-r-brouwer-pharmd-phd

"After a drug is taken orally and is absorbed into the bloodstream, it first goes the liver, where it comes in contact with hepatocytes, cells that contain the livers metabolic machinery. If the drug is taken up by the hepatocytes, it can be metabolized and/or excreted back into the bloodstream or into bile, which Brouwer calls the drainage compartment of the liver.

While the blood carries its portion of the drug to other parts of the body, the bile drains into the intestines, where some drug may be reabsorbed. Brouwer says researchers have only a limited understanding of the processes by which drugs are excreted into bile and the extent of reabsorption back into the blood.

Thats because its not easy to reach this drainage system, she says. Its all internal. Its only in people that have liver disease where they have exteriorized bile flow or some type of surgery that we even have access to that drainage compartment.

One of the major obstacles to progress in this field was the abilty to access, or at least quantitate in some way, the excretion of drugs in bile.

About five years ago, Brouwers lab developed a simple method to collect bile from healthy individuals. A volunteer swallows an multi-channel tube which is localized to the region of the intestine just below the stomach, where the bile drain dumps from the gall bladder into the intestines. A balloon at the end of the tube is positioned in the intestine below this drainge site. The balloon can be inflated to block the bile from flowing futher down the intestine. When the volunteer is given the naturally-occurring hormone cholecystokinen, the gall bladder contracts and expels bile into the intestine where the bile is trapped by the inflated balloon. Researchers can then siphon out the bile in the intestine through aspiration ports in the multi-channel tube and examine its contents, including the amount of drug excreted in the bile.

Being able to measure how much of a drug is taken up by the liver and drained into bile may be important in determining the efficacy or toxicity of the compound. Drugs and/or metabolites that are active in another part of the body need to get back into the blood from the liver in order to be effective. In other cases, the metabolites that are formed in the liver could cause toxicity if they are secreted into the intestines via bile.

Whats happened over the last several decades is that medicinal chemists have learned to design molecules that are metabolically stable, so they are not extensively metabolized by the liver, Brouwer says. But their structural features make them more likely to be excreted in bile, so theres the need to be able to really understand the extent of biliary excretion and, in some cases, to try and minimize that uptake and excretion process which removes drug from the circulation."

 

no x) just dont take too much. i took a supplement who contain this: Argile verte poudre 300 mg ; Bistorte racine 300 mg ; Bourdaine ecorce 300 mg ; Cascara ecorce 300 mg ; Charbon vegetal 300 mg ; Gingembre racine 300 mg ; Guimauve racine 300 mg ; Orme ecorce 300 mg ; Ispaghul (Psyllium rose) teguments 300 mg ; Verge d'or plante 300 mg
its a french supplement.

Anonyy what you have done completely makes sense from the science point of view..

Liver:

Oxidation : Mediated by the olive oil and lemon, isotherapy

Conjugation : Mediated by the kambucha, calcium d glucrate, beet root, artichoke

Bile:

Excretion : Psyllium, Charchoal, bentonite (Breaking the entroheptatic cycle for drug)

I think these all makes sense from theory point of view but only if they work for me... I am very happy for you Anonyy that these things made a difference for you. One day hopefully i will also be able to get rid of this Accutane..