The following side effects are expected to occur in the first few weeks of using trifarotene cream. These side effects usually decrease with continued use of trifarotene. Contact your doctor if these symptoms are severe and/or do not go away:
How Common (based on clinical studies)
| Dryness of skin | Up to 79.69% of all users |
| Skin peeling or scaling | Up to 77.49% of all users |
| Redness | Up to 73.1 % of all users |
| Burning, stinging, or tingling sensations | Up to 65.92% of all users |
If you experience any of the following side effects, stop using trifarotene immediately and contact your doctor or get emergency medical care right away:
- A sudden appearance of swelling and rash (known as hives)
- Swelling of the eyes, lips, tongue, or entire face
- Severe itching
- Trouble breathing or swallowing
- Changes in voice (hoarseness)
Trifarotene may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using trifarotene.
References
- Food and Drug Administration. AKLIEF-trifarotene cream. [online] Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211527s000lbl.pdf. [Accessed 07 Oct.2023].
- Wagner N, Benkali K, Alió Sáenz A, Poncet M, Graeber M. Clinical Pharmacology and Safety of Trifarotene, a First-in-Class RARγ-Selective Topical Retinoid. Journal of Clinical Pharmacology. 60(5), 660-668 (2020).
- Blume-Peytavi U, Fowler J, Kemény L, Draelos Z, Cook-Bolden F, Dirschka T, Eichenfield L, Graeber M, Ahmad F, Alió Saenz A, Rich P, Tanghetti E. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. Journal of the European Academy of Dermatology and Venereology. 34(1), 166-173 (2020).
- Tan J, Thiboutot D, Popp G, Gooderham M, Lynde C, Del Rosso J, Weiss J, Blume-Peytavi U, Weglovska J, Johnson S, Parish L, Witkowska D, Sanchez Colon N, Alió Saenz A, Ahmad F, Graeber M, Stein Gold L. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. Journal of the American Academy of Dermatology. 80(6), 1691-1699 (2019).
- DailyMed. National Library of Medicine. AKLIEF-trifarotene cream. [online] Available at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=62d910db-85a6-4696-b69b-4bd2f3080cfc. [Accessed 07 Oct.2023].
- Uptodate.com. (2023). Trifarotene. [online] [Accessed 07 Oct. 2023].