Trifarotene (Aklief®)

Topical Retinoid
Compare To Other Treatments

The following side effects are expected to occur in the first few weeks of using trifarotene cream. These side effects usually decrease with continued use of trifarotene. Contact your doctor if these symptoms are severe and/or do not go away:

How Common (based on clinical studies)

Dryness of skinUp to 79.69% of all users
Skin peeling or scalingUp to 77.49% of all users
Redness Up to 73.1 % of all users
Burning, stinging, or tingling sensationsUp to 65.92% of all users

If you experience any of the following side effects, stop using trifarotene immediately and contact your doctor or get emergency medical care right away:

  • A sudden appearance of swelling and rash (known as hives)
  • Swelling of the eyes, lips, tongue, or entire face
  • Severe itching
  • Trouble breathing or swallowing
  • Changes in voice (hoarseness)

Trifarotene may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using trifarotene.

  1. Food and Drug Administration. AKLIEF-trifarotene cream. [online] Available at: [Accessed 07 Oct.2023]. 
  2. Wagner N, Benkali K, Alió Sáenz A, Poncet M, Graeber M. Clinical Pharmacology and Safety of Trifarotene, a First-in-Class RARγ-Selective Topical Retinoid. Journal of Clinical Pharmacology. 60(5), 660-668 (2020).
  3. Blume-Peytavi U, Fowler J, Kemény L, Draelos Z, Cook-Bolden F, Dirschka T, Eichenfield L, Graeber M, Ahmad F, Alió Saenz A, Rich P, Tanghetti E. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. Journal of the European Academy of Dermatology and Venereology. 34(1), 166-173 (2020).
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  5. DailyMed. National Library of Medicine. AKLIEF-trifarotene cream. [online] Available at: [Accessed 07 Oct.2023].
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