Tretinoin / Benzoyl Peroxide (Twyneo®)

Topical Retinoid / Topical Antibacterial
Compare To Other Treatments

The following side effects are expected to occur in the first 2-4 weeks of treatment, and resolve with continued use of tretinoin / benzoyl peroxide. Contact your doctor if these symptoms are severe and/or do not go away after 4 weeks of treatment.

Tretinoin / Benzoyl peroxide may cause some side effects. Data on side-effects consists of a combination of government data as well as’s compilation of side-effect data from existing clinical studies:

How Common (based on clinical studies)

Redness and/or warmth in the areaUp to 40.1% of all users
PigmentationUp to 34% of all users
Dryness of the skinUp to 28% of all users
Skin peeling or scalingUp to 19% of all users
Burning, stinging, or tingling sensationUp to 13.6% of all users
ItchingUp to 12.9% of all users
Pain on the site of applicationUp to 12.04% of all users
Upper respiratory tract infectionUp to 2.19% of all users
NasopharyngitisUp to 1.42% of all users
NasopharyngitisUp to 1.09% of all users
Sun sensitivityUp to 1.07% of all users

If you experience any of the following side effects, stop using tretinoin / benzoyl peroxide immediately and contact your doctor or get emergency medical care right away:

  • A sudden appearance of swelling and rash (known as hives)
  • Swelling of the eyes, lips, tongue, or entire face
  • Severe itching
  • Trouble with breathing
  • Feeling dizzy or faint

Tretinoin / Benzoyl peroxide may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using tretinoin / benzoyl peroxide.

  1. DailyMed. Tretinoin and Benzoyl Peroxide. Available from: Cited 15 October 2023. 
  2. Del Rosso J, Sugarman J, Green L, Lain T, Levy-Hacham O, Mizrahi R, Gold LS. Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies. Journal of the American Academy of Dermatology. 89(4), 719-727 (2023).